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Conserved domains on  [gi|21450339|ref|NP_659179|]
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carboxylesterase 1F precursor [Mus musculus]

Protein Classification

carboxylesterase/lipase family protein( domain architecture ID 10444481)

carboxylesterase/lipase family protein similar to carboxylesterase, which catalyzes the hydrolysis of a carboxylic ester to form an alcohol and a carboxylate, and lipase, which hydrolyzes triglycerides into diglycerides and subsequently into monoglycerides and free fatty acids

CATH:  3.40.50.1820
EC:  3.1.1.-
PubMed:  8453375|3163407|8280778|9704093|11099800
SCOP:  3000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
22-545 0e+00

Carboxylesterase family;


:

Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 605.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339    22 SPPVVDTAHGKVLGKHVNVEGFsQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCSQDAARGQavndli 101
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG-KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   102 tnrKEKIHLEFSEDCLYLNIYTPADFSKNS-RLPVMVWIHGGGLKLGGASSFDGRALSAYENVVVVAIQYRLSIWGFFST 180
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKENKnKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   181 GDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDV 260
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   261 RPITEQIAVTAGCKTTTSAVIVHCMRQKTEEELLEIMHKLNLYKlslqgdtknSDQFVT--SVLDGVVLPKDPKEILAEK 338
Cdd:pfam00135 231 RQRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYG---------SVPFVPfgPVVDGDFLPEHPEELLKSG 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   339 NFNTVPYIVGINKQECGWLLPTMTGFLPADVKLDKKKAIALLEQFA--SMTGIPEDIIPVAVEKYTK--GSDDPDQIREG 414
Cdd:pfam00135 302 NFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLylLLVDLPEEISAALREEYLDwgDRDDPETSRRA 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   415 VLDAMGDVAFGVPSVIVSRGHRDTGAPTYMYEYQYYPSFSSpqRPKNVVGDHADDVYSVFGAPILR-EGASEEEINLSKM 493
Cdd:pfam00135 382 LVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSLR--YPKWVGVDHGDELPYVFGTPFVGaLLFTEEDEKLSRK 459

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 21450339   494 VMKFWANFARNGNPNGK-GLPHWPKY-DQKEGYLHIGGTTQQAQRLKEEEVTFW 545
Cdd:pfam00135 460 MMTYWTNFAKTGNPNGPeGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
22-545 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 605.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339    22 SPPVVDTAHGKVLGKHVNVEGFsQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCSQDAARGQavndli 101
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG-KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   102 tnrKEKIHLEFSEDCLYLNIYTPADFSKNS-RLPVMVWIHGGGLKLGGASSFDGRALSAYENVVVVAIQYRLSIWGFFST 180
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKENKnKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   181 GDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDV 260
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   261 RPITEQIAVTAGCKTTTSAVIVHCMRQKTEEELLEIMHKLNLYKlslqgdtknSDQFVT--SVLDGVVLPKDPKEILAEK 338
Cdd:pfam00135 231 RQRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYG---------SVPFVPfgPVVDGDFLPEHPEELLKSG 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   339 NFNTVPYIVGINKQECGWLLPTMTGFLPADVKLDKKKAIALLEQFA--SMTGIPEDIIPVAVEKYTK--GSDDPDQIREG 414
Cdd:pfam00135 302 NFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLylLLVDLPEEISAALREEYLDwgDRDDPETSRRA 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   415 VLDAMGDVAFGVPSVIVSRGHRDTGAPTYMYEYQYYPSFSSpqRPKNVVGDHADDVYSVFGAPILR-EGASEEEINLSKM 493
Cdd:pfam00135 382 LVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSLR--YPKWVGVDHGDELPYVFGTPFVGaLLFTEEDEKLSRK 459

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 21450339   494 VMKFWANFARNGNPNGK-GLPHWPKY-DQKEGYLHIGGTTQQAQRLKEEEVTFW 545
Cdd:pfam00135 460 MMTYWTNFAKTGNPNGPeGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 25-536 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 572.74  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339  25 VVDTAHGKVLGKHVNvegfsqPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCSQDaargqavNDLItNR 104
Cdd:cd00312   1 LVVTPNGKVRGVDEG------GVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQW-------DQLG-GG 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 105 KEKIHLEFSEDCLYLNIYTPADFSKNSRLPVMVWIHGGGLKLGGASSFDGRALSAY-ENVVVVAIQYRLSIWGFFSTGDE 183
Cdd:cd00312  67 LWNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREgDNVIVVSINYRLGVLGFLSTGDI 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 184 HSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDVRPI 263
Cdd:cd00312 147 ELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARGR 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 264 TEQIAVTAGCKTTTSAVIVHCMRQKTEEELLEIMHKLNLYKLSLQGdtknsdqFVTSVLDGVVLPKDPKEILAEKNFNTV 343
Cdd:cd00312 227 AKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYSPFL-------PFGPVVDGDFIPDDPEELIKEGKFAKV 299

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 344 PYIVGINKQECGWLLPTMtgfLPADVKLDKKKAIALLEQFASMT-GIPEDIIPVAVEKYTKGSDDPDQIREGVLDAMGDV 422
Cdd:cd00312 300 PLIIGVTKDEGGYFAAML---LNFDAKLIIETNDRWLELLPYLLfYADDALADKVLEKYPGDVDDSVESRKNLSDMLTDL 376

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 423 AFGVPSVIVSRGHRD-TGAPTYMYEYQYYPSFSSPQRPKNVVGDHADDVYSVFGAPILREGASEEEINLSKMVMKFWANF 501
Cdd:cd00312 377 LFKCPARYFLAQHRKaGGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLREEEEKLSRTMMKYWANF 456

                       490       500       510
                ....*....|....*....|....*....|....*..
gi 21450339 502 ARNGNPNGKG-LPHWPKYD-QKEGYLHIGGTTQQAQR 536
Cdd:cd00312 457 AKTGNPNTEGnLVVWPAYTsESEKYLDINIEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
20-545 3.30e-154

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 450.88  E-value: 3.30e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339  20 PSSPPVVDTAHGKVLGKHVNvegfsqPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCSQDAARGQAVND 99
Cdd:COG2272   9 AAAAPVVRTEAGRVRGVVEG------GVRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGDPGGP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 100 LITnrkekihlefSEDCLYLNIYTPADfSKNSRLPVMVWIHGGGLKLGGASS--FDGRALSAyENVVVVAIQYRLSIWGF 177
Cdd:COG2272  83 APG----------SEDCLYLNVWTPAL-AAGAKLPVMVWIHGGGFVSGSGSEplYDGAALAR-RGVVVVTINYRLGALGF 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 178 F-----STGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFi 252
Cdd:COG2272 151 LalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAGL- 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 253 pGMFTKDV-RPITEQIAVTAGCKTTTSAvivhCMRQKTEEELLEIMHKLnlyklslqgDTKNSDQFVTS-VLDGVVLPKD 330
Cdd:COG2272 230 -SVLTLAEaEAVGAAFAAALGVAPATLA----ALRALPAEELLAAQAAL---------AAEGPGGLPFGpVVDGDVLPED 295

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 331 PKEILAEKNFNTVPYIVGINKQEcgwllptMTGFLPADVKLDKKKAIALLEQFASMTGipeDIIPVAVEKYtkgsdDPDQ 410
Cdd:COG2272 296 PLEAFAAGRAADVPLLIGTNRDE-------GRLFAALLGDLGPLTAADYRAALRRRFG---DDADEVLAAY-----PAAS 360

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 411 IREGVLDAMGDVAFGVPSVIVSRGHRDTGAPTYMYEYQYYPSFSSPQRPKNVvgdHADDVYSVFG--APILREGASEEEI 488
Cdd:COG2272 361 PAEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLGAF---HGAELPFVFGnlDAPALTGLTPADR 437

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21450339 489 NLSKMVMKFWANFARNGNPNGKGLPHWPKYDQKEG-YLHIGGTTQQAQRLKEEE-VTFW 545
Cdd:COG2272 438 ALSDQMQAYWVNFARTGDPNGPGLPEWPAYDPEDRaVMVFDAEPRVVNDPDAEErLDLW 496
PRK10162 PRK10162
acetyl esterase;
121-223 3.78e-04

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 42.78  E-value: 3.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339  121 IYTPADFSKnsrlPVMVWIHGGGLKLGGASSFD--GRALSAYENVVVVAIQYRLSIWGFFSTGDEHSrgnwghldqVAAL 198
Cdd:PRK10162  73 LYYPQPDSQ----ATLFYLHGGGFILGNLDTHDriMRLLASYSGCTVIGIDYTLSPEARFPQAIEEI---------VAVC 139

                         90       100
                 ....*....|....*....|....*
gi 21450339  199 HWVQDNIANFGGDPGSVTIFGESAG 223
Cdd:PRK10162 140 CYFHQHAEDYGINMSRIGFAGDSAG 164
 
Name Accession Description Interval E-value
COesterase pfam00135
Carboxylesterase family;
22-545 0e+00

Carboxylesterase family;


Pssm-ID: 395084 [Multi-domain]  Cd Length: 513  Bit Score: 605.07  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339    22 SPPVVDTAHGKVLGKHVNVEGFsQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCSQDAARGQavndli 101
Cdd:pfam00135   1 DSPVVTTSLGRVRGKRLKVDGG-KPVYAFLGIPYAEPPVGELRFQPPEPPEPWTGVRDATKFGPRCPQNGDLTS------ 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   102 tnrKEKIHLEFSEDCLYLNIYTPADFSKNS-RLPVMVWIHGGGLKLGGASSFDGRALSAYENVVVVAIQYRLSIWGFFST 180
Cdd:pfam00135  74 ---PGSSGLEGSEDCLYLNVYTPKELKENKnKLPVMVWIHGGGFMFGSGSLYDGSYLAAEGDVIVVTINYRLGPLGFLST 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   181 GDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDV 260
Cdd:pfam00135 151 GDDEAPGNYGLLDQVLALRWVQENIASFGGDPNRVTLFGESAGAASVSLLLLSPLSKGLFHRAILMSGSALSPWAIQSNA 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   261 RPITEQIAVTAGCKTTTSAVIVHCMRQKTEEELLEIMHKLNLYKlslqgdtknSDQFVT--SVLDGVVLPKDPKEILAEK 338
Cdd:pfam00135 231 RQRAKELAKLVGCPTSDSAELVECLRSKPAEELLDAQLKLLVYG---------SVPFVPfgPVVDGDFLPEHPEELLKSG 301

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   339 NFNTVPYIVGINKQECGWLLPTMTGFLPADVKLDKKKAIALLEQFA--SMTGIPEDIIPVAVEKYTK--GSDDPDQIREG 414
Cdd:pfam00135 302 NFPKVPLLIGVTKDEGLLFAAYILDNVDILKALEEKLLRSLLIDLLylLLVDLPEEISAALREEYLDwgDRDDPETSRRA 381

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   415 VLDAMGDVAFGVPSVIVSRGHRDTGAPTYMYEYQYYPSFSSpqRPKNVVGDHADDVYSVFGAPILR-EGASEEEINLSKM 493
Cdd:pfam00135 382 LVELLTDYLFNCPVIRFADLHASRGTPVYMYSFDYRGSSLR--YPKWVGVDHGDELPYVFGTPFVGaLLFTEEDEKLSRK 459

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....
gi 21450339   494 VMKFWANFARNGNPNGK-GLPHWPKY-DQKEGYLHIGGTTQQAQRLKEEEVTFW 545
Cdd:pfam00135 460 MMTYWTNFAKTGNPNGPeGLPKWPPYtDENGQYLSIDLEPRVKQGLKAERCAFW 513
Esterase_lipase cd00312
Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on ...
 25-536 0e+00

Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These catalytic residues are responsible for the nucleophilic attack on the carbonyl carbon atom of the ester bond. In contrast with other alpha/beta hydrolase fold family members, p-nitrobenzyl esterase and acetylcholine esterase have a Glu instead of Asp at the active site carboxylate.


Pssm-ID: 238191 [Multi-domain]  Cd Length: 493  Bit Score: 572.74  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339  25 VVDTAHGKVLGKHVNvegfsqPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCSQDaargqavNDLItNR 104
Cdd:cd00312   1 LVVTPNGKVRGVDEG------GVYSFLGIPYAEPPVGDLRFKEPQPYEPWSDVLDATSYPPSCMQW-------DQLG-GG 66

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 105 KEKIHLEFSEDCLYLNIYTPADFSKNSRLPVMVWIHGGGLKLGGASSFDGRALSAY-ENVVVVAIQYRLSIWGFFSTGDE 183
Cdd:cd00312  67 LWNAKLPGSEDCLYLNVYTPKNTKPGNSLPVMVWIHGGGFMFGSGSLYPGDGLAREgDNVIVVSINYRLGVLGFLSTGDI 146

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 184 HSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFIPGMFTKDVRPI 263
Cdd:cd00312 147 ELPGNYGLKDQRLALKWVQDNIAAFGGDPDSVTIFGESAGGASVSLLLLSPDSKGLFHRAISQSGSALSPWAIQENARGR 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 264 TEQIAVTAGCKTTTSAVIVHCMRQKTEEELLEIMHKLNLYKLSLQGdtknsdqFVTSVLDGVVLPKDPKEILAEKNFNTV 343
Cdd:cd00312 227 AKRLARLLGCNDTSSAELLDCLRSKSAEELLDATRKLLLFSYSPFL-------PFGPVVDGDFIPDDPEELIKEGKFAKV 299

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 344 PYIVGINKQECGWLLPTMtgfLPADVKLDKKKAIALLEQFASMT-GIPEDIIPVAVEKYTKGSDDPDQIREGVLDAMGDV 422
Cdd:cd00312 300 PLIIGVTKDEGGYFAAML---LNFDAKLIIETNDRWLELLPYLLfYADDALADKVLEKYPGDVDDSVESRKNLSDMLTDL 376

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 423 AFGVPSVIVSRGHRD-TGAPTYMYEYQYYPSFSSPQRPKNVVGDHADDVYSVFGAPILREGASEEEINLSKMVMKFWANF 501
Cdd:cd00312 377 LFKCPARYFLAQHRKaGGSPVYAYVFDHRSSLSVGRWPPWLGTVHGDEIFFVFGNPLLKEGLREEEEKLSRTMMKYWANF 456

                       490       500       510
                ....*....|....*....|....*....|....*..
gi 21450339 502 ARNGNPNGKG-LPHWPKYD-QKEGYLHIGGTTQQAQR 536
Cdd:cd00312 457 AKTGNPNTEGnLVVWPAYTsESEKYLDINIEGTEIKQ 493
PnbA COG2272
Carboxylesterase type B [Lipid transport and metabolism];
20-545 3.30e-154

Carboxylesterase type B [Lipid transport and metabolism];


Pssm-ID: 441873  Cd Length: 500  Bit Score: 450.88  E-value: 3.30e-154
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339  20 PSSPPVVDTAHGKVLGKHVNvegfsqPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYPPMCSQDAARGQAVND 99
Cdd:COG2272   9 AAAAPVVRTEAGRVRGVVEG------GVRVFLGIPYAAPPVGELRWRAPQPVEPWTGVRDATEFGPACPQPPRPGDPGGP 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 100 LITnrkekihlefSEDCLYLNIYTPADfSKNSRLPVMVWIHGGGLKLGGASS--FDGRALSAyENVVVVAIQYRLSIWGF 177
Cdd:COG2272  83 APG----------SEDCLYLNVWTPAL-AAGAKLPVMVWIHGGGFVSGSGSEplYDGAALAR-RGVVVVTINYRLGALGF 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 178 F-----STGDEHSRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRAISESGVAFi 252
Cdd:COG2272 151 LalpalSGESYGASGNYGLLDQIAALRWVRDNIAAFGGDPDNVTIFGESAGAASVAALLASPLAKGLFHRAIAQSGAGL- 229

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 253 pGMFTKDV-RPITEQIAVTAGCKTTTSAvivhCMRQKTEEELLEIMHKLnlyklslqgDTKNSDQFVTS-VLDGVVLPKD 330
Cdd:COG2272 230 -SVLTLAEaEAVGAAFAAALGVAPATLA----ALRALPAEELLAAQAAL---------AAEGPGGLPFGpVVDGDVLPED 295

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 331 PKEILAEKNFNTVPYIVGINKQEcgwllptMTGFLPADVKLDKKKAIALLEQFASMTGipeDIIPVAVEKYtkgsdDPDQ 410
Cdd:COG2272 296 PLEAFAAGRAADVPLLIGTNRDE-------GRLFAALLGDLGPLTAADYRAALRRRFG---DDADEVLAAY-----PAAS 360

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 411 IREGVLDAMGDVAFGVPSVIVSRGHRDTGAPTYMYEYQYYPSFSSPQRPKNVvgdHADDVYSVFG--APILREGASEEEI 488
Cdd:COG2272 361 PAEALAALATDRVFRCPARRLAEAHAAAGAPVYLYRFDWRSPPLRGFGLGAF---HGAELPFVFGnlDAPALTGLTPADR 437

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 21450339 489 NLSKMVMKFWANFARNGNPNGKGLPHWPKYDQKEG-YLHIGGTTQQAQRLKEEE-VTFW 545
Cdd:COG2272 438 ALSDQMQAYWVNFARTGDPNGPGLPEWPAYDPEDRaVMVFDAEPRVVNDPDAEErLDLW 496
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
121-225 3.90e-19

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 86.08  E-value: 3.90e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 121 IYTPADFSKNsrLPVMVWIHGGGLKLGGASSFDG--RALSAYENVVVVAIQYRLSiwgffstgDEHSrgnW-GHLDQV-A 196
Cdd:COG0657   3 VYRPAGAKGP--LPVVVYFHGGGWVSGSKDTHDPlaRRLAARAGAAVVSVDYRLA--------PEHP---FpAALEDAyA 69

                        90       100
                ....*....|....*....|....*....
gi 21450339 197 ALHWVQDNIANFGGDPGSVTIFGESAGGY 225
Cdd:COG0657  70 ALRWLRANAAELGIDPDRIAVAGDSAGGH 98
Abhydrolase_3 pfam07859
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.
 136-224 4.08e-14

alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes.


Pssm-ID: 400284 [Multi-domain]  Cd Length: 208  Bit Score: 71.47  E-value: 4.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   136 MVWIHGGGLKLGGASSFDG--RALSAYENVVVVAIQYRLSiwgffstgDEHSrgnW--GHLDQVAALHWVQDNIANFGGD 211
Cdd:pfam07859   1 LVYFHGGGFVLGSADTHDRlcRRLAAEAGAVVVSVDYRLA--------PEHP---FpaAYDDAYAALRWLAEQAAELGAD 69

                          90
                  ....*....|...
gi 21450339   212 PGSVTIFGESAGG 224
Cdd:pfam07859  70 PSRIAVAGDSAGG 82
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
121-250 1.27e-11

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 64.65  E-value: 1.27e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 121 IYTPADfskNSRLPVMVWIHGGGLKLGGASSFDGRALSAyENVVVVAIQYRlsiwgffstGDEHSRGNWGHL---DQVAA 197
Cdd:COG1506  14 LYLPAD---GKKYPVVVYVHGGPGSRDDSFLPLAQALAS-RGYAVLAPDYR---------GYGESAGDWGGDevdDVLAA 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 21450339 198 LHWVqdnIANFGGDPGSVTIFGESAGGYSVSILILspLSKNLFHRAISESGVA 250
Cdd:COG1506  81 IDYL---AARPYVDPDRIGIYGHSYGGYMALLAAA--RHPDRFKAAVALAGVS 128
BD-FAE pfam20434
BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, ...
 119-225 1.32e-08

BD-FAE; This family represents a novel bifunctional feruloyl and acetyl xylan esterase (BD-FAE, previously known as bifunctional carbohydrate esterase (CE)), which is active on complex natural xylans and was identified as the basis of a monophyletic clade gathering all homologs identified in PULs (polysaccharide utilization loci) predicted to act on xylan. It adopts an alpha-beta-hydrolase fold with the catalytic triad Ser-Asp-His. This new family of proteins is a new candidate for biomass processing due to its capacity to remove ferulic acid and acetic acid from natural corn and birchwood xylan substrates.


Pssm-ID: 466583 [Multi-domain]  Cd Length: 215  Bit Score: 55.26  E-value: 1.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   119 LNIYTPADFSKNsrLPVMVWIHGGGLKLG---GASSFDGRALSAY--ENVVVVAIQYRLSIWGFFStgdehsrgnwghlD 193
Cdd:pfam20434   1 LDIYLPKNAKGP--YPVVIWIHGGGWNSGdkeADMGFMTNTVKALlkAGYAVASINYRLSTDAKFP-------------A 65

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 21450339   194 QV----AALHWVQDNIANFGGDPGSVTIFGESAGGY 225
Cdd:pfam20434  66 QIqdvkAAIRFLRANAAKYGIDTNKIALMGFSAGGH 101
COG4099 COG4099
Predicted peptidase [General function prediction only];
120-225 6.22e-08

Predicted peptidase [General function prediction only];


Pssm-ID: 443275 [Multi-domain]  Cd Length: 235  Bit Score: 53.82  E-value: 6.22e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 120 NIYTPADFSKNSRLPVMVWIHGGG--------LKLGGASSFDGRALSAYENVVVVAIQYrlsiwgffstgdeHSRGNWGH 191
Cdd:COG4099  36 RLYLPKGYDPGKKYPLVLFLHGAGergtdnekQLTHGAPKFINPENQAKFPAIVLAPQC-------------PEDDYWSD 102

                        90       100       110
                ....*....|....*....|....*....|....*
gi 21450339 192 LDQVAALH-WVQDNIANFGGDPGSVTIFGESAGGY 225
Cdd:COG4099 103 TKALDAVLaLLDDLIAEYRIDPDRIYLTGLSMGGY 137
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
119-268 3.59e-06

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 49.08  E-value: 3.59e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 119 LNIYTPADFSKNS-RLPVMVWIHGGGlklGGASSF--DGRALSAYEN---------VVVVAIQYRLSiwgffSTGDEHSR 186
Cdd:COG2382  97 VWVYLPPGYDNPGkKYPVLYLLDGGG---GDEQDWfdQGRLPTILDNliaagkippMIVVMPDGGDG-----GDRGTEGP 168

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 187 GNWGHLDQVAA--LHWVQDNiANFGGDPGSVTIFGESAGGY-SVSILILSPlskNLFHRAISESGvAFIPGMFTKDVRPI 263
Cdd:COG2382 169 GNDAFERFLAEelIPFVEKN-YRVSADPEHRAIAGLSMGGLaALYAALRHP---DLFGYVGSFSG-SFWWPPGDADRGGW 243


                ....*
gi 21450339 264 TEQIA 268
Cdd:COG2382 244 AELLA 248
Esterase pfam00756
Putative esterase; This family contains Esterase D. However it is not clear if all members of ...
 119-248 8.59e-06

Putative esterase; This family contains Esterase D. However it is not clear if all members of the family have the same function. This family is related to the pfam00135 family.


Pssm-ID: 395613 [Multi-domain]  Cd Length: 246  Bit Score: 47.46  E-value: 8.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   119 LNIYTPADFSKNSRLPVMVWIHGGG-LKLGGASSFDGRALSAYENVVVVAIqyrlsiwgFFSTGDEHSR-GNWGHLDQVA 196
Cdd:pfam00756  10 VQVYLPEDYPPGRKYPVLYLLDGTGwFQNGPAKEGLDRLAASGEIPPVIIV--------GSPRGGEVSFySDWDRGLNAT 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21450339   197 ALHW-------VQDNI-----ANFGGDPGSVTIFGESAGGYSVSILIL-SPlskNLFHRAISESG 248
Cdd:pfam00756  82 EGPGayayetfLTQELpplldANFPTAPDGRALAGQSMGGLGALYLALkYP---DLFGSVSSFSP 143
PRK10162 PRK10162
acetyl esterase;
121-223 3.78e-04

acetyl esterase;


Pssm-ID: 236660 [Multi-domain]  Cd Length: 318  Bit Score: 42.78  E-value: 3.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339  121 IYTPADFSKnsrlPVMVWIHGGGLKLGGASSFD--GRALSAYENVVVVAIQYRLSIWGFFSTGDEHSrgnwghldqVAAL 198
Cdd:PRK10162  73 LYYPQPDSQ----ATLFYLHGGGFILGNLDTHDriMRLLASYSGCTVIGIDYTLSPEARFPQAIEEI---------VAVC 139

                         90       100
                 ....*....|....*....|....*
gi 21450339  199 HWVQDNIANFGGDPGSVTIFGESAG 223
Cdd:PRK10162 140 CYFHQHAEDYGINMSRIGFAGDSAG 164
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
151-266 3.93e-04

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 41.83  E-value: 3.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339   151 SFDGRA-LSAYENVVVVAIQYRLSiwGFFSTGDEHS-RGNWGHL---DQVAALHWVqdnIANFGGDPGSVTIFGESAGGY 225
Cdd:pfam00326   2 SFSWNAqLLADRGYVVAIANGRGS--GGYGEAFHDAgKGDLGQNefdDFIAAAEYL---IEQGYTDPDRLAIWGGSYGGY 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 21450339   226 SVSiLILSPLSkNLFHRAISESGVAFIPGMFTKDVRPITEQ 266
Cdd:pfam00326  77 LTG-AALNQRP-DLFKAAVAHVPVVDWLAYMSDTSLPFTER 115
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 121-224 5.26e-04

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 42.30  E-value: 5.26e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21450339 121 IYTPADFSKNSRLPVMVWIHGGGlklGGASSFDG----RALSAYENVVVVA----IQYRLSIWGFFSTGDEHSRGnwGHL 192
Cdd:COG3509  41 LYVPAGYDGGAPLPLVVALHGCG---GSAADFAAgtglNALADREGFIVVYpegtGRAPGRCWNWFDGRDQRRGR--DDV 115

                        90       100       110
                ....*....|....*....|....*....|..
gi 21450339 193 DQVAALhwVQDNIANFGGDPGSVTIFGESAGG 224
Cdd:COG3509 116 AFIAAL--VDDLAARYGIDPKRVYVTGLSAGG 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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