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Conserved domains on  [gi|50593524|ref|NP_660290|]
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swi5-dependent recombination DNA repair protein 1 homolog isoform b [Homo sapiens]

Protein Classification

Mei5 domain-containing protein( domain architecture ID 12105422)

Mei5 domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Mei5 pfam10376
Double-strand recombination repair protein; Mei5 is one of a pair of meiosis-specific proteins ...
12-223 8.64e-90

Double-strand recombination repair protein; Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologs, Rad51 and Dmc1. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.


:

Pssm-ID: 431242 [Multi-domain]  Cd Length: 207  Bit Score: 263.17  E-value: 8.64e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593524    12 PSTPQASANPSSPYTNSSRKQPMSATLRERLRKTRFSFNSSYNVVKRLKVESEENDQTFSEKPASSTEENCLeFQESFKH 91
Cdd:pfam10376   1 PSTPDARPTPSSSKTKSSGKQPMSKTLRERLKKTRSSFNSCYSVVKRLKVENEENNELSSEKPLSSKEENCL-FQQSIKI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593524    92 IDSEFEENTNLKNTLKNLNVCESqsldsGSCSALQNEFVSEKLPKQRLNAEKAKLVKQVQEKEDLLRRLKLVKMYRSKND 171
Cdd:pfam10376  80 LDSEPEESRNLKSTEKNRGVCKS-----GSEMSLILNSLPEKIPKKELEAEKRKLEKQVDEKEELLRRLKLVKMYRSKND 154
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 50593524   172 LSQLQLLIKKWRSCSQLLLYELQSAVSE-ENKKLSLTQLIDHYGLDDKLLHYN 223
Cdd:pfam10376 155 LSELQSLIKKWRNCSQLLLEELQSAMSEsENKKLTMTELIDRYGLDDKLLHYN 207
 
Name Accession Description Interval E-value
Mei5 pfam10376
Double-strand recombination repair protein; Mei5 is one of a pair of meiosis-specific proteins ...
12-223 8.64e-90

Double-strand recombination repair protein; Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologs, Rad51 and Dmc1. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.


Pssm-ID: 431242 [Multi-domain]  Cd Length: 207  Bit Score: 263.17  E-value: 8.64e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593524    12 PSTPQASANPSSPYTNSSRKQPMSATLRERLRKTRFSFNSSYNVVKRLKVESEENDQTFSEKPASSTEENCLeFQESFKH 91
Cdd:pfam10376   1 PSTPDARPTPSSSKTKSSGKQPMSKTLRERLKKTRSSFNSCYSVVKRLKVENEENNELSSEKPLSSKEENCL-FQQSIKI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593524    92 IDSEFEENTNLKNTLKNLNVCESqsldsGSCSALQNEFVSEKLPKQRLNAEKAKLVKQVQEKEDLLRRLKLVKMYRSKND 171
Cdd:pfam10376  80 LDSEPEESRNLKSTEKNRGVCKS-----GSEMSLILNSLPEKIPKKELEAEKRKLEKQVDEKEELLRRLKLVKMYRSKND 154
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 50593524   172 LSQLQLLIKKWRSCSQLLLYELQSAVSE-ENKKLSLTQLIDHYGLDDKLLHYN 223
Cdd:pfam10376 155 LSELQSLIKKWRNCSQLLLEELQSAMSEsENKKLTMTELIDRYGLDDKLLHYN 207
 
Name Accession Description Interval E-value
Mei5 pfam10376
Double-strand recombination repair protein; Mei5 is one of a pair of meiosis-specific proteins ...
12-223 8.64e-90

Double-strand recombination repair protein; Mei5 is one of a pair of meiosis-specific proteins which facilitate the loading of Dmc1 on to Rad51 on DNA at double-strand breaks during recombination. Recombination is carried out by a large protein complex based around the two RecA homologs, Rad51 and Dmc1. This complex may play both a catalytic and a structural role in the interaction between homologous chromosomes during meiosis. Mei5 is seen to contain a coiled-coli region.


Pssm-ID: 431242 [Multi-domain]  Cd Length: 207  Bit Score: 263.17  E-value: 8.64e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593524    12 PSTPQASANPSSPYTNSSRKQPMSATLRERLRKTRFSFNSSYNVVKRLKVESEENDQTFSEKPASSTEENCLeFQESFKH 91
Cdd:pfam10376   1 PSTPDARPTPSSSKTKSSGKQPMSKTLRERLKKTRSSFNSCYSVVKRLKVENEENNELSSEKPLSSKEENCL-FQQSIKI 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 50593524    92 IDSEFEENTNLKNTLKNLNVCESqsldsGSCSALQNEFVSEKLPKQRLNAEKAKLVKQVQEKEDLLRRLKLVKMYRSKND 171
Cdd:pfam10376  80 LDSEPEESRNLKSTEKNRGVCKS-----GSEMSLILNSLPEKIPKKELEAEKRKLEKQVDEKEELLRRLKLVKMYRSKND 154
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 50593524   172 LSQLQLLIKKWRSCSQLLLYELQSAVSE-ENKKLSLTQLIDHYGLDDKLLHYN 223
Cdd:pfam10376 155 LSELQSLIKKWRNCSQLLLEELQSAMSEsENKKLTMTELIDRYGLDDKLLHYN 207
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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