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Conserved domains on  [gi|42734463|ref|NP_663451|]
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TBC1 domain family member 22A isoform 1 [Mus musculus]

Protein Classification

TBC domain-containing protein( domain architecture ID 10640016)

TBC (Tre-2/Bub2/Cdc1) domain-containing protein may function as a GTPase activator protein of Rab-like small GTPases

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
218-468 8.02e-39

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 140.90  E-value: 8.02e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463    218 SWSGIPKPVRPMTWKLLSGYLPANvdrrpatLQRKQKEYFAFIEHYYSSRNDEVHQdtyrqIHIDIPRMSPEALILQ--- 294
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPMD-------TSADKDLYSRLLKETAPDDKSIVHQ-----IEKDLRRTFPEHSFFQdke 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463    295 PKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFiceytdrEDvdkvdvssvpaevlrniEADTYWCMSKLLDGIQ 374
Cdd:smart00164  69 GPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVM-------ED-----------------EEDAFWCLVKLMERYG 124
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463    375 DN-YTFAQPGIQMKVKMLEELVSRIDERVHRHLDGHEVRYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSepEGFsHFHL 453
Cdd:smart00164 125 PNfYLPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLYALRWFLTLFARELPLEIVLRIWDVLFA--EGS-DFLF 201
                          250
                   ....*....|....*
gi 42734463    454 YVCAAFLVRWRREIL 468
Cdd:smart00164 202 RVALALLKLHRDVLL 216
PRK10819 super family cl35954
transport protein TonB; Provisional
112-132 6.98e-03

transport protein TonB; Provisional


The actual alignment was detected with superfamily member PRK10819:

Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 38.12  E-value: 6.98e-03
                         10        20
                 ....*....|....*....|.
gi 42734463  112 PSQKTTEPEPEPQPIAEPPVP 132
Cdd:PRK10819  67 PPEPVVEPEPEPEPIPEPPKE 87
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
218-468 8.02e-39

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 140.90  E-value: 8.02e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463    218 SWSGIPKPVRPMTWKLLSGYLPANvdrrpatLQRKQKEYFAFIEHYYSSRNDEVHQdtyrqIHIDIPRMSPEALILQ--- 294
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPMD-------TSADKDLYSRLLKETAPDDKSIVHQ-----IEKDLRRTFPEHSFFQdke 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463    295 PKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFiceytdrEDvdkvdvssvpaevlrniEADTYWCMSKLLDGIQ 374
Cdd:smart00164  69 GPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVM-------ED-----------------EEDAFWCLVKLMERYG 124
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463    375 DN-YTFAQPGIQMKVKMLEELVSRIDERVHRHLDGHEVRYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSepEGFsHFHL 453
Cdd:smart00164 125 PNfYLPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLYALRWFLTLFARELPLEIVLRIWDVLFA--EGS-DFLF 201
                          250
                   ....*....|....*
gi 42734463    454 YVCAAFLVRWRREIL 468
Cdd:smart00164 202 RVALALLKLHRDVLL 216
COG5210 COG5210
GTPase-activating protein [General function prediction only];
127-488 5.54e-38

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 145.72  E-value: 5.54e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463 127 AEPPVPPSGDLRLVKSVSES-HTPCPSESTGDTVPLQRSQSLPHSATVTLSGTSDPHALADSALSKRET------SRLDK 199
Cdd:COG5210 110 NKSLKSQSTSPELPKRLKDSlPTHLPEASSTEKDFSSFKGSSSLNSNPELNKEINELSLKEEPQKLRYYelaadkLWISY 189
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463 200 F--KQLLAGPNTdLEELRKLSWSGIPKPVRPMTWKLLSGYLPaNVDRRPATLQRKQKEYfafIEHYYSSrndevhQDTYR 277
Cdd:COG5210 190 LdpNPLSFLPVQ-LSKLRELIRKGIPNELRGDVWEFLLGIGF-DLDKNPGLYERLLNLH---REAKIPT------QEIIS 258
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463 278 QIHIDIPRMSPEALILQPKVT---EIFERILFIWAIRHPASGYVQGINDLVTPFFVVFiceytdredvdkvdvssvpaev 354
Cdd:COG5210 259 QIEKDLSRTFPDNSLFQTEISiraENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVL---------------------- 316
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463 355 lrNIEADTYWCMSKLLD--GIQDNYTFAQPGIQMKVKMLEELVSRIDERVHRHLDGHEVRYLQFAFRWMNNLLMRELPLR 432
Cdd:COG5210 317 --ESEEQAFWCLVKLLKnyGLPGYFLKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLE 394
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 42734463 433 CTIRLWDTYQSE-PEGFSHFHLYVCAAFLVRWRREIlEERDFQELLLFLQNLPTARW 488
Cdd:COG5210 395 YALRIWDCLFLEgSSMLFQLALAILKLLRDKLLKLD-SDELLDLLLKQLFLHSGKEA 450
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
278-468 5.67e-38

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 137.39  E-value: 5.67e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463   278 QIHIDIPRMSPEALILQPKVTEI-FERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYtdredvdkvdvssvpaevlr 356
Cdd:pfam00566  11 QIEKDVPRTFPHSFFFDNGPGQNsLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEE-------------------- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463   357 nieaDTYWCMSKLLD--GIQDNYTFAQPGIQMKVKMLEELVSRIDERVHRHLDGHEVRYLQFAFRWMNNLLMRELPLRCT 434
Cdd:pfam00566  71 ----DAFWCFVSLLEnyLLRDFYTPDFPGLKRDLYVFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTV 146
                         170       180       190
                  ....*....|....*....|....*....|....
gi 42734463   435 IRLWDTYQSepEGFSHFHLYVCAAFLVRWRREIL 468
Cdd:pfam00566 147 LRIWDYFFL--EGEKFVLFRVALAILKRFREELL 178
PRK10819 PRK10819
transport protein TonB; Provisional
112-132 6.98e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 38.12  E-value: 6.98e-03
                         10        20
                 ....*....|....*....|.
gi 42734463  112 PSQKTTEPEPEPQPIAEPPVP 132
Cdd:PRK10819  67 PPEPVVEPEPEPEPIPEPPKE 87
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
218-468 8.02e-39

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 140.90  E-value: 8.02e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463    218 SWSGIPKPVRPMTWKLLSGYLPANvdrrpatLQRKQKEYFAFIEHYYSSRNDEVHQdtyrqIHIDIPRMSPEALILQ--- 294
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPMD-------TSADKDLYSRLLKETAPDDKSIVHQ-----IEKDLRRTFPEHSFFQdke 68
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463    295 PKVTEIFERILFIWAIRHPASGYVQGINDLVTPFFVVFiceytdrEDvdkvdvssvpaevlrniEADTYWCMSKLLDGIQ 374
Cdd:smart00164  69 GPGQESLRRVLKAYALYNPEVGYCQGMNFLAAPLLLVM-------ED-----------------EEDAFWCLVKLMERYG 124
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463    375 DN-YTFAQPGIQMKVKMLEELVSRIDERVHRHLDGHEVRYLQFAFRWMNNLLMRELPLRCTIRLWDTYQSepEGFsHFHL 453
Cdd:smart00164 125 PNfYLPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDLGITPSLYALRWFLTLFARELPLEIVLRIWDVLFA--EGS-DFLF 201
                          250
                   ....*....|....*
gi 42734463    454 YVCAAFLVRWRREIL 468
Cdd:smart00164 202 RVALALLKLHRDVLL 216
COG5210 COG5210
GTPase-activating protein [General function prediction only];
127-488 5.54e-38

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 145.72  E-value: 5.54e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463 127 AEPPVPPSGDLRLVKSVSES-HTPCPSESTGDTVPLQRSQSLPHSATVTLSGTSDPHALADSALSKRET------SRLDK 199
Cdd:COG5210 110 NKSLKSQSTSPELPKRLKDSlPTHLPEASSTEKDFSSFKGSSSLNSNPELNKEINELSLKEEPQKLRYYelaadkLWISY 189
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463 200 F--KQLLAGPNTdLEELRKLSWSGIPKPVRPMTWKLLSGYLPaNVDRRPATLQRKQKEYfafIEHYYSSrndevhQDTYR 277
Cdd:COG5210 190 LdpNPLSFLPVQ-LSKLRELIRKGIPNELRGDVWEFLLGIGF-DLDKNPGLYERLLNLH---REAKIPT------QEIIS 258
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463 278 QIHIDIPRMSPEALILQPKVT---EIFERILFIWAIRHPASGYVQGINDLVTPFFVVFiceytdredvdkvdvssvpaev 354
Cdd:COG5210 259 QIEKDLSRTFPDNSLFQTEISiraENLRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVL---------------------- 316
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463 355 lrNIEADTYWCMSKLLD--GIQDNYTFAQPGIQMKVKMLEELVSRIDERVHRHLDGHEVRYLQFAFRWMNNLLMRELPLR 432
Cdd:COG5210 317 --ESEEQAFWCLVKLLKnyGLPGYFLKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLMFAFRWFLTLFVREFPLE 394
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 42734463 433 CTIRLWDTYQSE-PEGFSHFHLYVCAAFLVRWRREIlEERDFQELLLFLQNLPTARW 488
Cdd:COG5210 395 YALRIWDCLFLEgSSMLFQLALAILKLLRDKLLKLD-SDELLDLLLKQLFLHSGKEA 450
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
278-468 5.67e-38

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 137.39  E-value: 5.67e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463   278 QIHIDIPRMSPEALILQPKVTEI-FERILFIWAIRHPASGYVQGINDLVTPFFVVFICEYtdredvdkvdvssvpaevlr 356
Cdd:pfam00566  11 QIEKDVPRTFPHSFFFDNGPGQNsLRRILKAYSIYNPDVGYCQGMNFIAAPLLLVYLDEE-------------------- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42734463   357 nieaDTYWCMSKLLD--GIQDNYTFAQPGIQMKVKMLEELVSRIDERVHRHLDGHEVRYLQFAFRWMNNLLMRELPLRCT 434
Cdd:pfam00566  71 ----DAFWCFVSLLEnyLLRDFYTPDFPGLKRDLYVFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTV 146
                         170       180       190
                  ....*....|....*....|....*....|....
gi 42734463   435 IRLWDTYQSepEGFSHFHLYVCAAFLVRWRREIL 468
Cdd:pfam00566 147 LRIWDYFFL--EGEKFVLFRVALAILKRFREELL 178
PRK10819 PRK10819
transport protein TonB; Provisional
112-132 6.98e-03

transport protein TonB; Provisional


Pssm-ID: 236768 [Multi-domain]  Cd Length: 246  Bit Score: 38.12  E-value: 6.98e-03
                         10        20
                 ....*....|....*....|.
gi 42734463  112 PSQKTTEPEPEPQPIAEPPVP 132
Cdd:PRK10819  67 PPEPVVEPEPEPEPIPEPPKE 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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