|
Name |
Accession |
Description |
Interval |
E-value |
| HrpA |
COG1643 |
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis]; |
54-677 |
2.64e-171 |
|
HrpA-like RNA helicase [Translation, ribosomal structure and biogenesis];
Pssm-ID: 441249 [Multi-domain] Cd Length: 836 Bit Score: 510.78 E-value: 2.64e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVvGVTQPRRVAAVTVAGRVADERGAVLGHEVG 133
Cdd:COG1643 10 LPVSAVLPELLAALRAHQVVVLAAPPGAGKTTQLPLALLELGWGAGGRI-GMLEPRRLAARAAAERMAEELGEPVGETVG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 134 YCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKK-RGDLRLIVASATLD 212
Cdd:COG1643 89 YRVRFEDKVSA-ATRIEVVTEGILLRELQRDPELEGVDTVIFDEFHERSLNADLLLALLLDLQPAlRPDLKLLVMSATLD 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 213 AEKFRDFFNqnetsdPARdtsvTLTVEGRTFPVDIFYL--QSPVPDYIKATVDTVVKIHQtEGDGDILAFLTGQEEvetv 290
Cdd:COG1643 168 AERFARLLG------DAP----VIESSGRTYPVEVRYRplPADERDLEDAVADAVREALA-EEPGDILVFLPGERE---- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 291 vsmlIEQARALARTGMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNP 370
Cdd:COG1643 233 ----IRRTAEALRGRLPPDTEILPLYGRLSAAEQDRAFAPAPHGRRRIVLATNIAETSLTVPGIRYVIDSGLARIPRYDP 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 371 RTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSP 450
Cdd:COG1643 309 RSGVTRLPTERISQASANQRAGRAGRLAPGICYRLWSEEDFARRPAFTDPEILRADLASLILELAAWGLGDPEDLPFLDP 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 451 PPAQSMVQALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEVLSIAAMMQIQNVFvfpsnqksq 530
Cdd:COG1643 389 PPARAIADARALLQELGALDADGRLT-PLGRALARLPLDPRLARMLLAAAELGCLREAAILAALLSERDPR--------- 458
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 531 atrvhRKFAveEGDHLTMLNVYEAFikhnkssQWCQEHFLNYKGLVRAATVRDQLKKLLvkfQVPKVSSEGDPDPVLRCI 610
Cdd:COG1643 459 -----RGAA--GSDLLARLNLWRRL-------REQQREFLSYLRLREWRDLARQLRRLL---GEGANEEPADYEAIGLLL 521
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 611 VSGFFAN-AARFHSSGAYR-------VIY-NEVIQTSKYYM-------------RDVTAIESAWLLELAPHFYQQGTHLS 668
Cdd:COG1643 522 ALAYPDRiARRRGEGGRYLlargrgaALFpGSPLAKKEWLVaaelvggaaeariRLAAPIDPEWLEELAAHLIKRYSEPH 601
|
....*....
gi 21919420 669 LKAKRAKVQ 677
Cdd:COG1643 602 WDKKRGRVV 610
|
|
| DEAH_box_HrpA |
TIGR01967 |
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ... |
52-659 |
1.77e-146 |
|
RNA helicase HrpA; This model represents HrpA, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria and a few high-GC Gram-positive bacteria. HrpA is about 1300 amino acids long, while its paralog HrpB, also uncharacterized, is about 800 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. The HrpA/B homolog from Borrelia is 500 amino acids shorter but appears to be derived from HrpA rather than HrpB. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273900 [Multi-domain] Cd Length: 1283 Bit Score: 458.46 E-value: 1.77e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 52 QKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGrVVGVTQPRRVAAVTVAGRVADERGAVLGHE 131
Cdd:TIGR01967 64 DNLPVSAKREDIAEAIAENQVVIIAGETGSGKTTQLPKICLELGRGSHG-LIGHTQPRRLAARTVAQRIAEELGTPLGEK 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 132 VGYCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATL 211
Cdd:TIGR01967 143 VGYKVRFHDQVSS-NTLVKLMTDGILLAETQQDRFLSRYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKIIITSATI 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 212 DAEKFRDFFNQnetsdpardtSVTLTVEGRTFPVDIFY-----LQSPVP-DYIKATVDTVVKIHQtEGDGDILAFLTGQE 285
Cdd:TIGR01967 222 DPERFSRHFNN----------APIIEVSGRTYPVEVRYrplveEQEDDDlDQLEAILDAVDELFA-EGPGDILIFLPGER 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 286 EVEtvvsmliEQARALARTGMKkHLRVLPMYAGLPSFEQMKVFErvSHSVRKVIVATNVAETSITISGIVYVIDCGFMKL 365
Cdd:TIGR01967 291 EIR-------DAAEILRKRNLR-HTEILPLYARLSNKEQQRVFQ--PHSGRRIVLATNVAETSLTVPGIHYVIDTGTARI 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 366 RAYNPRTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRF 445
Cdd:TIGR01967 361 SRYSYRTKVQRLPIEPISQASANQRKGRCGRVAPGICIRLYSEEDFNSRPEFTDPEILRTNLASVILQMLALRLGDIAAF 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 446 HFMSPPPAQSMVQALELLYALGGLDKD---CRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEVLSIAAMMQIQNVFV 522
Cdd:TIGR01967 441 PFIEAPDPRAIRDGFRLLEELGALDDDeaePQLT-PIGRQLAQLPVDPRLARMLLEAHRLGCLQEVLIIASALSIQDPRE 519
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 523 FPSNQKSQATRVHRKFAVEEGDHLTMLNVYEAF------IKHNKSSQWCQEHFLNYkglVRAATVRD---QLKKLLVKFQ 593
Cdd:TIGR01967 520 RPMEKQQAADQAHARFKDPRSDFLSRVNLWRHIeeqrqaLSANQFRNACRKQYLNY---LRVREWQDiyrQLTQVVKELG 596
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 594 VPKVSSEGDPDPVLRCIVSGFFAN--------------AARFH---SSGAYR-----VIYNEVIQTSKYYMRDVTAIESA 651
Cdd:TIGR01967 597 LKLNEEPADYDAIHKALLSGLLSQigmkdekheydgarGRKFHifpGSPLFKkppkwVMAAELVETSKLYARLVAKIEPE 676
|
....*...
gi 21919420 652 WLLELAPH 659
Cdd:TIGR01967 677 WVEPVAGH 684
|
|
| PRK11131 |
PRK11131 |
ATP-dependent RNA helicase HrpA; Provisional |
54-659 |
1.54e-139 |
|
ATP-dependent RNA helicase HrpA; Provisional
Pssm-ID: 182986 [Multi-domain] Cd Length: 1294 Bit Score: 440.27 E-value: 1.54e-139
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGrVVGVTQPRRVAAVTVAGRVADERGAVLGHEVG 133
Cdd:PRK11131 73 LPVSQKKQDILEAIRDHQVVIVAGETGSGKTTQLPKICLELGRGVKG-LIGHTQPRRLAARTVANRIAEELETELGGCVG 151
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 134 YCIRFDD-CTDplATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLD 212
Cdd:PRK11131 152 YKVRFNDqVSD--NTMVKLMTDGILLAEIQQDRLLMQYDTIIIDEAHERSLNIDFILGYLKELLPRRPDLKVIITSATID 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 213 AEKFRDFFNQnetsdpardtSVTLTVEGRTFPVDIFYlqSPV--------PDYIKATVDTVVKIhQTEGDGDILAFLTGQ 284
Cdd:PRK11131 230 PERFSRHFNN----------APIIEVSGRTYPVEVRY--RPIveeaddteRDQLQAIFDAVDEL-GREGPGDILIFMSGE 296
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 285 EEVEtvvsmliEQARALARTGMKkHLRVLPMYAGLPSFEQMKVFErvSHSVRKVIVATNVAETSITISGIVYVIDCGFMK 364
Cdd:PRK11131 297 REIR-------DTADALNKLNLR-HTEILPLYARLSNSEQNRVFQ--SHSGRRIVLATNVAETSLTVPGIKYVIDPGTAR 366
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 365 LRAYNPRTAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLR 444
Cdd:PRK11131 367 ISRYSYRTKVQRLPIEPISQASANQRKGRCGRVSEGICIRLYSEDDFLSRPEFTDPEILRTNLASVILQMTALGLGDIAA 446
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 445 FHFMSPPPAQSMVQALELLYALGGLDKDC-----RLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEVLSIAAMMQIQN 519
Cdd:PRK11131 447 FPFVEAPDKRNIQDGVRLLEELGAITTDEqasayKLT-PLGRQLAQLPVDPRLARMVLEAQKHGCVREVMIITSALSIQD 525
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 520 VFVFPSNQKSQATRVHRKFAVEEGDHLTMLNVYEAFIKHNK---SSQW---CQEHFLNYKGLVRAATVRDQLKKLLVKFQ 593
Cdd:PRK11131 526 PRERPMDKQQASDEKHRRFADKESDFLAFVNLWNYLQEQQKalsSNQFrrlCRTDYLNYLRVREWQDIYTQLRQVVKELG 605
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 594 VPKVSSEGDPDPVLRCIVSGFF---------------ANAARFH---SSGAYR-----VIYNEVIQTSKYYMRDVTAIES 650
Cdd:PRK11131 606 IPVNSEPAEYREIHTALLTGLLshigmkdaekqeytgARNARFSifpGSGLFKkppkwVMVAELVETSRLWGRIAARIEP 685
|
....*....
gi 21919420 651 AWLLELAPH 659
Cdd:PRK11131 686 EWIEPLAQH 694
|
|
| DEXHc_DHX35 |
cd17980 |
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and ... |
54-238 |
8.32e-133 |
|
DEXH-box helicase domain of DEAH-box helicase 35; DHX35 plays a role in colorectal cancers and seems to be associated with risk to thyroid cancers. It also has been shown to positively regulate poxviruses, such as Myxoma virus. DEAH-box helicase 35 (DHX35) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350738 [Multi-domain] Cd Length: 185 Bit Score: 388.37 E-value: 8.32e-133
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEVG 133
Cdd:cd17980 1 LPVFKLRNHILYLVENYQTIVIVGETGCGKSTQIPQYLAEAGWTAGGRVVGCTQPRRVAAVTVAGRVAEEMGAVLGHEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 134 YCIRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDA 213
Cdd:cd17980 81 YCIRFDDCTDPQATRIKFLTDGMLVREMMLDPLLTKYSVIMLDEAHERTLYTDILIGLLKKIQKKRGDLRLIVASATLDA 160
|
170 180
....*....|....*....|....*
gi 21919420 214 EKFRDFFNQNETSDPARDTSVTLTV 238
Cdd:cd17980 161 EKFRDFFNQNETNDPSKDTATILSV 185
|
|
| DEAH_box_HrpB |
TIGR01970 |
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but ... |
54-516 |
1.05e-97 |
|
ATP-dependent helicase HrpB; This model represents HrpB, one of two related but uncharacterized DEAH-box ATP-dependent helicases in many Proteobacteria, but also in a few species of other lineages. The member from Rhizobium meliloti has been designated HelO. HrpB is typically about 800 residues in length, while its paralog HrpA (TIGR01967), also uncharacterized, is about 1300 amino acids long. Related characterized eukarotic proteins are RNA helicases associated with pre-mRNA processing. [Unknown function, Enzymes of unknown specificity]
Pssm-ID: 273901 [Multi-domain] Cd Length: 819 Bit Score: 318.63 E-value: 1.05e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPqyLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEVG 133
Cdd:TIGR01970 1 LPIHAVLPALRDALAAHPQVVLEAPPGAGKSTAVP--LALLDAPGIGGKIIMLEPRRLAARSAAQRLASQLGEAVGQTVG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 134 YCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKK-RGDLRLIVASATLD 212
Cdd:TIGR01970 79 YRVRGENKVSR-RTRLEVVTEGILTRMIQDDPELDGVGALIFDEFHERSLDADLGLALALDVQSSlREDLKILAMSATLD 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 213 AEKFRDFFNqnetsdparDTSVtLTVEGRTFPVDIFYLQSPVPDYIK-ATVDTVVKIHQTEGdGDILAFLTGQEEVETVV 291
Cdd:TIGR01970 158 GERLSSLLP---------DAPV-VESEGRSFPVEIRYLPLRGDQRLEdAVSRAVEHALASET-GSILVFLPGQAEIRRVQ 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 292 SMLIEQARAlartgmkkHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPR 371
Cdd:TIGR01970 227 EQLAERLDS--------DVLICPLYGELSLAAQDRAIKPDPQGRRKVVLATNIAETSLTIEGIRVVIDSGLARVARFDPK 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 372 TAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPP 451
Cdd:TIGR01970 299 TGITRLETVRISQASATQRAGRAGRLEPGVCYRLWSEEQHQRLPAQDEPEILQADLSGLALELAQWGAKDPSDLRWLDAP 378
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 21919420 452 PAQSMVQALELLYALGGLDKDCRLTEpLGMRIAEFPLNPMFAKMLLESGNFGCSQEVLSIAAMMQ 516
Cdd:TIGR01970 379 PSVALAAARQLLQRLGALDAQGRLTA-HGKAMAALGCHPRLAAMLLSAHSTGLAALACDLAALLE 442
|
|
| DEXHc_DHX33 |
cd17978 |
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA ... |
54-221 |
2.46e-84 |
|
DEXH-box helicase domain of DEAH-box helicase 33; DEAH-box helicase 33 (DHX33) stimulates RNA polymerase I transcription of the 47S precursor rRNA. DHX33 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438710 [Multi-domain] Cd Length: 178 Bit Score: 263.06 E-value: 2.46e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGwTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEVG 133
Cdd:cd17978 1 LPIYSARKRLLEELRKHDTVIIIGETGSGKTTQIPQYLYEAG-FARGGMIGITQPRRVAAVSVAKRVAEEMGVELGQLVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 134 YCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGD-----LRLIVAS 208
Cdd:cd17978 80 YSVRFDDVTSE-ETRIKYMTDGMLLREAIGDPLLSKYSVIILDEAHERTVHTDVLFGLVKSAQRRRKEqklspLKVIIMS 158
|
170
....*....|...
gi 21919420 209 ATLDAEKFRDFFN 221
Cdd:cd17978 159 ATLDADLFSEYFN 171
|
|
| DEXHc_RHA-like |
cd17917 |
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) ... |
71-222 |
7.97e-84 |
|
DEXH-box helicase domain of DEAD-like helicase RHA family proteins; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438707 [Multi-domain] Cd Length: 159 Bit Score: 260.85 E-value: 7.97e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 71 QTVVIVGETGCGKSTQIPQYLAEAGWTAEGRV-VGVTQPRRVAAVTVAGRVADERGAVLGHEVGYCIRFDDCTDPlATRI 149
Cdd:cd17917 2 QVVVIVGETGSGKTTQVPQFLLEDGLAKGGKGrIVCTQPRRIAAISVAERVAEERGEKLGEEVGYQIRFESKTSS-KTRI 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21919420 150 KFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFFNQ 222
Cdd:cd17917 81 KFCTDGILLRELLSDPLLSGYSHVILDEAHERSLDTDFLLGLLKDLLRKRPDLKVILMSATLDAEKFSSYFGG 153
|
|
| PRK11664 |
PRK11664 |
ATP-dependent RNA helicase HrpB; Provisional |
54-514 |
1.32e-79 |
|
ATP-dependent RNA helicase HrpB; Provisional
Pssm-ID: 236950 [Multi-domain] Cd Length: 812 Bit Score: 269.87 E-value: 1.32e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIP-QYLAEAGWTaeGRVVgVTQPRRVAAVTVAGRVADERGAVLGHEV 132
Cdd:PRK11664 4 LPVAAVLPELLTALKTAPQVLLKAPTGAGKSTWLPlQLLQHGGIN--GKII-MLEPRRLAARNVAQRLAEQLGEKPGETV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 133 GYCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKK-RGDLRLIVASATL 211
Cdd:PRK11664 81 GYRMRAESKVGP-NTRLEVVTEGILTRMIQRDPELSGVGLVILDEFHERSLQADLALALLLDVQQGlRDDLKLLIMSATL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 212 DAEKFRDFFNQnetsdpardtSVTLTVEGRTFPVDIFYLQSPVPDYIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVV 291
Cdd:PRK11664 160 DNDRLQQLLPD----------APVIVSEGRSFPVERRYQPLPAHQRFDEAVARATAELLRQESGSLLLFLPGVGEIQRVQ 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 292 SMLIEQaralartgMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPR 371
Cdd:PRK11664 230 EQLASR--------VASDVLLCPLYGALSLAEQQKAILPAPAGRRKVVLATNIAETSLTIEGIRLVVDSGLERVARFDPK 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 372 TAIECLVVVPVSQASANQRAGRGGRNRSGKCYRLYTEEAFDQLPQSTVPEMQRSNLAPVILQLKALGIDNVLRFHFMSPP 451
Cdd:PRK11664 302 TGLTRLVTQRISQASMTQRAGRAGRLEPGICLHLYSKEQAERAAAQSEPEILHSDLSGLLLELLQWGCHDPAQLSWLDQP 381
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 21919420 452 PAQSMVQALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFgcSQEVLSIAAM 514
Cdd:PRK11664 382 PAAALAAAKRLLQQLGALDGQGRLT-ARGRKMAALGNDPRLAAMLVAAKED--DEAALATAAK 441
|
|
| DEXHc_DHX8 |
cd17971 |
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as ... |
49-220 |
5.99e-79 |
|
DEXH-box helicase domain of DEAH-box helicase 8; DEAH-box helicase 8 (DHX8 ,also known as pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22) acts late in the splicing of pre-mRNA and mediates the release of the spliced mRNA from spliceosomes. DHX8 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350729 [Multi-domain] Cd Length: 179 Bit Score: 248.94 E-value: 5.99e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 49 QQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVvGVTQPRRVAAVTVAGRVADERGAVL 128
Cdd:cd17971 1 EQRESLPIYKLKEQLIQAVHDNQILVVIGETGSGKTTQITQYLAEAGYTSRGKI-GCTQPRRVAAMSVAKRVAEEFGCCL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 129 GHEVGYCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVAS 208
Cdd:cd17971 80 GQEVGYTIRFEDCTSP-ETVIKYMTDGMLLRECLIDPDLSQYSVIMLDEAHERTIHTDVLFGLLKKTVQKRPDLKLIVTS 158
|
170
....*....|..
gi 21919420 209 ATLDAEKFRDFF 220
Cdd:cd17971 159 ATLDAVKFSQYF 170
|
|
| SF2_C_RHA |
cd18791 |
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A ... |
243-406 |
1.51e-75 |
|
C-terminal helicase domain of the RNA helicase A (RHA) family helicases; The RNA helicase A (RHA) family includes RHA, also called DEAH-box helicase 9 (DHX9), DHX8, DHX15-16, DHX32-38, and many others. The RHA family members are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350178 [Multi-domain] Cd Length: 171 Bit Score: 239.74 E-value: 1.51e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 243 FPVDIFYLQSPV-----------PDYIKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLieqaRALARTGMKKHLR 311
Cdd:cd18791 1 FPVEVYYLEDILellgissekedPDYVDAAVRLILQIHRTEEPGDILVFLPGQEEIERLCELL----REELLSPDLGKLL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 312 VLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFMKLRAYNPRTAIECLVVVPVSQASANQRA 391
Cdd:cd18791 77 VLPLHSSLPPEEQQRVFEPPPPGVRKVVLATNIAETSITIPGVVYVIDSGLVKEKVYDPRTGLSSLVTVWISKASAEQRA 156
|
170
....*....|....*
gi 21919420 392 GRGGRNRSGKCYRLY 406
Cdd:cd18791 157 GRAGRTRPGKCYRLY 171
|
|
| DEXHc_DHX15 |
cd17973 |
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA ... |
45-221 |
3.74e-75 |
|
DEXH-box helicase domain of DEAH-box helicase 15; DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438709 [Multi-domain] Cd Length: 187 Bit Score: 239.62 E-value: 3.74e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 45 LSIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWT-AEGRVVGVTQPRRVAAVTVAGRVADE 123
Cdd:cd17973 4 FEILEKRRELPVWEQKEDFLKLLKNNQILVLVGETGSGKTTQIPQFVLDDELPhQPKKLVACTQPRRVAAMSVAQRVAEE 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 124 RGAVLGHEVGYCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLR 203
Cdd:cd17973 84 MDVKLGEEVGYSIRFEDCSSA-KTILKYMTDGMLLREAMSDPLLSRYSVIILDEAHERTLATDILMGLLKEVVRRRPDLK 162
|
170
....*....|....*...
gi 21919420 204 LIVASATLDAEKFRDFFN 221
Cdd:cd17973 163 LIVMSATLDAGKFQKYFD 180
|
|
| DEXHc_DHX16 |
cd17974 |
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably ... |
54-222 |
1.35e-74 |
|
DEXH-box helicase domain of DEAH-box helicase 16; DEAH-box helicase 16 (DHX16) is probably involved in pre-mRNA splicing. DHX16 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350732 [Multi-domain] Cd Length: 174 Bit Score: 237.40 E-value: 1.35e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEVG 133
Cdd:cd17974 1 LPVYPYRDDLLAAVKEHQVLIIVGETGSGKTTQIPQYLHEAGYTKGGGKIGCTQPRRVAAMSVAARVAEEMGVKLGNEVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 134 YCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDA 213
Cdd:cd17974 81 YSIRFEDCTSE-KTVLKYMTDGMLLREFLTEPDLASYSVMIIDEAHERTLHTDILFGLVKDIARFRPDLKLLISSATMDA 159
|
....*....
gi 21919420 214 EKFRDFFNQ 222
Cdd:cd17974 160 EKFSAFFDD 168
|
|
| DEXHc_DHX38 |
cd17983 |
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as ... |
54-220 |
2.83e-67 |
|
DEXH-box helicase domain of DEAH-box helicase 38; DEAH-box helicase 38 (DHX38, also known as PRP16) is involved in pre-mRNA splicing. DHX38 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350741 [Multi-domain] Cd Length: 173 Bit Score: 218.10 E-value: 2.83e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGrVVGVTQPRRVAAVTVAGRVADERGAVLGHEVG 133
Cdd:cd17983 1 LPIFAVRQELLNVIRDNNVVIVVGETGSGKTTQLTQYLHEDGYTDYG-MIGCTQPRRVAAMSVAKRVSEEMGVELGEEVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 134 YCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDA 213
Cdd:cd17983 80 YAIRFEDCTSE-NTVIKYMTDGILLRESLRDPDLDKYSAIIMDEAHERSLNTDVLFGLLREVVARRRDLKLIVTSATMDA 158
|
....*..
gi 21919420 214 EKFRDFF 220
Cdd:cd17983 159 DKFADFF 165
|
|
| DEXHc_DHX37 |
cd17982 |
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the ... |
54-218 |
1.54e-61 |
|
DEXH-box helicase domain of DEAH-box helicase 37; DHX37 plays a role in the development of the human nervous system and has been linked to schizophrenia. It also negatively regulates poxviruses such as Myxoma virus. DEAH-box helicase 37 (DHX37) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350740 [Multi-domain] Cd Length: 191 Bit Score: 203.74 E-value: 1.54e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAE----GRVVGVTQPRRVAAVTVAGRVADERGaVLG 129
Cdd:cd17982 1 LPILAEEQEIMEAINENPVVIICGETGSGKTTQVPQFLYEAGFGSPesdnPGMIGITQPRRVAAVSMAKRVAEELN-VFG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 130 HEVGYCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGD-------- 201
Cdd:cd17982 80 KEVSYQIRYDSTVSE-NTKIKFMTDGVLLKEIQTDFLLRKYSVIIIDEAHERSVNTDILIGMLSRIVPLRAKlylqdqtv 158
|
170
....*....|....*....
gi 21919420 202 --LRLIVASATLDAEKFRD 218
Cdd:cd17982 159 kpLKLVIMSATLRVEDFTE 177
|
|
| DEXHc_DHX40 |
cd17984 |
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the ... |
54-220 |
9.17e-57 |
|
DEXH-box helicase domain of DEAH-box helicase 40; DEAH-box helicase 40 (DHX40) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350742 [Multi-domain] Cd Length: 178 Bit Score: 190.45 E-value: 9.17e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVvGVTQPRRVAAVTVAGRVADERGAVLGHEVG 133
Cdd:cd17984 1 LPIQKQRKKLVQAVRDNSFLIVTGNTGSGKTTQLPKYLYEAGFSQHGMI-GVTQPRRVAAISVAQRVAEEMKCTLGSKVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 134 YCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKI--QKKRG---DLRLIVAS 208
Cdd:cd17984 80 YQVRFDDCSSK-ETAIKYMTDGCLLRHILADPNLTKYSVIILDEAHERSLTTDILFGLLKKLfqEKSPNrkeHLKVVVMS 158
|
170
....*....|..
gi 21919420 209 ATLDAEKFRDFF 220
Cdd:cd17984 159 ATLELAKLSAFF 170
|
|
| DEXHc_DHX34 |
cd17979 |
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in ... |
54-222 |
4.63e-51 |
|
DEXH-box helicase domain of DEAH-box helicase 34; DEAH-box helicase 34 (DHX34) plays a role in the nonsense-mediated decay (NMD), a surveillance mechanism that degrades aberrant mRNAs. DHX34 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350737 [Multi-domain] Cd Length: 170 Bit Score: 174.94 E-value: 4.63e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAegrvVGVTQPRRVAAVTVAGRVADERGAVLGHEVG 133
Cdd:cd17979 1 LPIAQYREKIIELLKTHQVVIVAGDTGCGKSTQVPQYLLAAGFRH----IACTQPRRIACISLAKRVAFESLNQYGSKVA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 134 YCIRFDDcTDPLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDA 213
Cdd:cd17979 77 YQIRFER-TRTLATKLLFLTEGLLLRQIQRDASLPQYNVLILDEVHERHLHGDFLLGVLRCLLRLRPDLKLILMSATINI 155
|
....*....
gi 21919420 214 EKFRDFFNQ 222
Cdd:cd17979 156 ELFSGYFEG 164
|
|
| DEXHc_HrpA |
cd17989 |
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA ... |
54-221 |
9.05e-51 |
|
DEXH-box helicase domain of ATP-dependent RNA helicase HrpA; HrpA is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpA belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350747 [Multi-domain] Cd Length: 173 Bit Score: 174.18 E-value: 9.05e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGrVVGVTQPRRVAAVTVAGRVADERGAVLGHEVG 133
Cdd:cd17989 1 LPVSQKRDEIAKAIAENQVVIIAGETGSGKTTQLPKICLELGRGIRG-LIGHTQPRRLAARSVAERIAEELKTELGGAVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 134 YCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDA 213
Cdd:cd17989 80 YKVRFTDQTSD-ETCVKLMTDGILLAETQTDRYLRAYDTIIIDEAHERSLNIDFLLGYLKQLLPRRPDLKVIITSATIDA 158
|
....*...
gi 21919420 214 EKFRDFFN 221
Cdd:cd17989 159 ERFSRHFN 166
|
|
| DEXHc_DHX36 |
cd17981 |
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as ... |
54-221 |
9.57e-46 |
|
DEXH-box helicase domain of DEAH-box helicase 36; DEAH-box helicase 36 (DHX36, also known as G4-resolvase 1 or G4R1, MLE-like protein 1 and RNA helicase associated with AU-rich element or RHAU) unwinds a G4-quadruplex in human telomerase RNA. DHX36 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350739 [Multi-domain] Cd Length: 180 Bit Score: 160.78 E-value: 9.57e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYL----AEAGWTAEGRVVgVTQPRRVAAVTVAGRVADERG--AV 127
Cdd:cd17981 1 LPSYGMKQEIINMIDNNQVTVISGETGCGKTTQVTQFIlddaIERGKGSSCRIV-CTQPRRISAISVAERVAAERAesCG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 128 LGHEVGYCIRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVA 207
Cdd:cd17981 80 LGNSTGYQIRLESRKPRKQGSILYCTTGIVLQWLQSDPHLSNVSHLVLDEIHERNLQSDVLMGIVKDLLPFRSDLKVILM 159
|
170
....*....|....
gi 21919420 208 SATLDAEKFRDFFN 221
Cdd:cd17981 160 SATLNAEKFSDYFN 173
|
|
| DEXHc_DHX29 |
cd17975 |
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of ... |
54-222 |
1.30e-43 |
|
DEXH-box helicase domain of DEAH-box helicase 29; DEAH-box helicase 29 (DHX29) is a part of the 43S pre-initiation complex involved in translation initiation of mRNAs with structured 5'-UTRs. DHX29 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350733 [Multi-domain] Cd Length: 183 Bit Score: 155.07 E-value: 1.30e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAE----AGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLG 129
Cdd:cd17975 1 LPVFKHRESILETLKRHRVVVVAGETGSGKSTQVPQFLLEdlllNGGTAQKCNIVCTQPRRISAMSLATRVCEELGCESG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 130 -----HEVGYCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRL 204
Cdd:cd17975 81 pggknSLCGYQIRMESRTGE-ATRLLYCTTGVLLRKLQEDGLLSSISHIIVDEVHERSVQSDFLLIILKEILHKRSDLHL 159
|
170
....*....|....*...
gi 21919420 205 IVASATLDAEKFRDFFNQ 222
Cdd:cd17975 160 ILMSATVDCEKFSSYFTH 177
|
|
| DEXHc_DHX57 |
cd17985 |
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the ... |
54-221 |
1.02e-42 |
|
DEXH-box helicase domain of DEAH-box helicase 57; DEAH-box helicase 57 (DHX57) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350743 [Multi-domain] Cd Length: 177 Bit Score: 152.30 E-value: 1.02e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGW-TAEGRVVGV--TQPRRVAAVTVAGRVADERGAVLGH 130
Cdd:cd17985 1 LPAWQERETILELLEKHQVLVISGMTGCGKTTQIPQFILDNSLqGPPLPVANIicTQPRRISAISVAERVAQERAERVGQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 131 EVGYCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASAT 210
Cdd:cd17985 81 SVGYQIRLESVKSS-ATRLLYCTTGVLLRRLEGDPTLQGVTHVIVDEVHERTEESDFLLLVLKDLMVQRPDLKVILMSAT 159
|
170
....*....|.
gi 21919420 211 LDAEKFRDFFN 221
Cdd:cd17985 160 LNAELFSDYFN 170
|
|
| DEXHc_HrpB |
cd17990 |
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA ... |
54-216 |
1.09e-40 |
|
DEXH-box helicase domain of ATP-dependent helicase HrpB; HrpB is part of the HrpB-HrpA two-partner secretion (TPS) system, a secretion pathway important to the secretion of large virulence-associated proteins. HrpB belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 438711 [Multi-domain] Cd Length: 174 Bit Score: 146.32 E-value: 1.09e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVgVTQPRRVAAVTVAGRVADERGAVLGHEVG 133
Cdd:cd17990 1 LPIAAVLPALRAALDAGGQVVLEAPPGAGKTTRVPLALLAELWIAGGKII-VLEPRRVAARAAARRLATLLGEAPGETVG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 134 YCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQK-KRGDLRLIVASATLD 212
Cdd:cd17990 80 YRVRGESRVGR-RTRVEVVTEGVLLRRLQRDPELSGVGAVILDEFHERSLDADLALALLLEVQQlLRDDLRLLAMSATLD 158
|
....
gi 21919420 213 AEKF 216
Cdd:cd17990 159 GDGL 162
|
|
| DEXQc_DQX1 |
cd17986 |
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 ... |
54-219 |
4.04e-40 |
|
DEXQ-box helicase domain of DEAQ-box RNA dependent ATPase 1; DEAQ-box RNA dependent ATPase 1 (DQX1) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350744 [Multi-domain] Cd Length: 177 Bit Score: 145.04 E-value: 4.04e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIV-GETGCGKSTQIPQYLAEAGWT---AEGRVVgVTQPRRVAAVTVAGRVADERGAVLG 129
Cdd:cd17986 1 LPIWAAKFTFLEQLESPSGIVLVsGEPGSGKSTQVPQWCAEFALSrgfQKGQVT-VTQPHPLAARSLALRVADEMDLNLG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 130 HEVGYCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASA 209
Cdd:cd17986 80 HEVGYSIPQEDCTGP-NTILRFCWDRLLLQEMTSTPLLGAWGVVVLDEAQERSVASDSLLGLLKDVRLQRPELRVVVVTS 158
|
170
....*....|
gi 21919420 210 TLDAEKFRDF 219
Cdd:cd17986 159 PALEPKLRAF 168
|
|
| DEXHc_DHX9 |
cd17972 |
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ... |
7-220 |
7.40e-40 |
|
DEXH-box helicase domain of DEAH-box helicase 9; DEAH-box helicase 9 (DHX9, also known as ATP-dependent RNA helicase A or RHA and leukophysin or LKP) plays an important role in many cellular processes, including regulation of DNA replication, transcription, translation, microRNA biogenesis, RNA processing and transport, and maintenance of genomic stability. DHX9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350730 [Multi-domain] Cd Length: 234 Bit Score: 146.13 E-value: 7.40e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 7 PVKFWKPGT-----EGPGVSISEERQSVT-ENSGTTIIYNPYAALSIEQQRQKLPVFKLRNHILYLVENYQTVVIVGETG 80
Cdd:cd17972 6 PQSNWNPWTssnidEGPLAFATPEQISMDlKNELMYQREQDHNLQQILQERELLPVKKFREEILEAISNNPVVIIRGATG 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 81 CGKSTQIPQYLAE----AGWTAEGRVVgVTQPRRVAAVTVAGRVADERGAVLGHEVGYCIRFDDCTDPLATRIKFLTDGM 156
Cdd:cd17972 86 CGKTTQVPQYILDdfiqNDRAAECNIV-VTQPRRISAVSVAERVAFERGEEVGKSCGYSVRFESVLPRPHASILFCTVGV 164
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 21919420 157 LVREMmvDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATLDAEKFRDFF 220
Cdd:cd17972 165 LLRKL--EAGIRGISHVIVDEIHERDINTDFLLVVLRDVVQAYPDLRVILMSATIDTSMFCEYF 226
|
|
| DEXHc_DHX30 |
cd17976 |
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an ... |
54-220 |
5.73e-39 |
|
DEXH-box helicase domain of DEAH-box helicase 30; DEAH-box helicase 30 (DHX30) plays an important role in the assembly of the mitochondrial large ribosomal subunit. DHX30 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350734 [Multi-domain] Cd Length: 178 Bit Score: 141.85 E-value: 5.73e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAE----AGWTAEGRVVgVTQPRRVAAVTVAGRVADERGAVLG 129
Cdd:cd17976 1 LPVDSHKESILSAIEQNPVVVISGDTGCGKTTRIPQFILEdyvlRGRGARCNVV-ITQPRRISAVSVAQRVAHELGPNLR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 130 HEVGYCIRFDDCTDPLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASA 209
Cdd:cd17976 80 RNVGYQVRLESRPPPRGGALLFCTVGVLLKKLQSNPRLEGVSHVIVDEVHERDVNTDFLLILLKGVLQLNPELRVVLMSA 159
|
170
....*....|.
gi 21919420 210 TLDAEKFRDFF 220
Cdd:cd17976 160 TGDNQRLSRYF 170
|
|
| DEXHc_DHX32 |
cd17977 |
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the ... |
54-220 |
1.62e-38 |
|
DEXH-box helicase domain of DEAH-box helicase 32; DEAH-box helicase 32 (DHX32) belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350735 [Multi-domain] Cd Length: 176 Bit Score: 140.73 E-value: 1.62e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGR--VVGVTQPRRVAAVTVAGRVADERGAVLGHE 131
Cdd:cd17977 1 LPVWEAKYEFMESLAHNQIVIVSGDAKTGKSSQIPQWCAEYCLSAHYQhgVVVCTQVHKQTAVWLALRVADEMDVNIGHE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 132 VGYCIRFDDCTDPlATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATL 211
Cdd:cd17977 81 VGYVIPFENCCTN-ETILRYCTDDMLLREMMSDPLLESYGVIILDDAHERTVSTDVLLGLLKDVLLSRPELKLVIITCPH 159
|
....*....
gi 21919420 212 DAEKFRDFF 220
Cdd:cd17977 160 LSSKLLSYY 168
|
|
| DEXHc_YTHDC2 |
cd17987 |
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) ... |
54-221 |
1.36e-36 |
|
DEXH-box helicase domain of YTH domain containing 2; YTH domain containing 2 (YTHDC2) regulates mRNA translation and stability via binding to N6-methyladenosine, a modified RNA nucleotide enriched in the stop codons and 3' UTRs of eukaryotic messenger RNAs. YTHDC2 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350745 [Multi-domain] Cd Length: 176 Bit Score: 135.34 E-value: 1.36e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGW-TAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEV 132
Cdd:cd17987 1 LPVFEKQEQIVRIIKENKVVLIVGETGSGKTTQIPQFLLDDCYaNGIPCRIFCTQPRRLAAIAVAERVAAERGEKIGQTV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 133 GYCIRFDDCTDPlATRIKFLTDGMLVREMMV-DPLLTKYSVIMLDEAHERTLYTDIAIGLLKKIQKKRGDLRLIVASATL 211
Cdd:cd17987 81 GYQIRLESRVSP-KTLLTFCTNGVLLRTLMAgDSALSTVTHVIVDEVHERDRFSDFLLTKLRDILQKHPNLKLILSSAAL 159
|
170
....*....|
gi 21919420 212 DAEKFRDFFN 221
Cdd:cd17987 160 DVNLFIRYFG 169
|
|
| DEXHc_TDRD9 |
cd17988 |
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also ... |
54-220 |
2.25e-31 |
|
DEXH-box helicase domain of tudor domain containing 9; Tudor domain containing 9 (TDRD9, also known as HIG-1or NET54 or C14orf75) is a part of the nuclear PIWI-interacting RNA (piRNA) pathway essential for transposon silencing and male fertility TDRD9 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350746 [Multi-domain] Cd Length: 180 Bit Score: 120.68 E-value: 2.25e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 54 LPVFKLRNHILYLVENYQTVVIVGETGCGKSTQIPQY-LAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVLGHEV 132
Cdd:cd17988 1 LPIYAKREEILSLIEANSVVIIKGATGCGKTTQLPQFiLDHYYKRGKYCNIVVTQPRRIAAISIARRVSQEREWTLGSLV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 133 GYCIRFDDcTDPLATRIKFLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKK-IQKKRGDLRLIVASATL 211
Cdd:cd17988 81 GYQVGLER-PASEETRLIYCTTGVLLQKLINNKTLTEYTHIILDEVHERDQELDFLLLVVRRlLRTNSRHVKIILMSATI 159
|
....*....
gi 21919420 212 DAEKFRDFF 220
Cdd:cd17988 160 SCKEFADYF 168
|
|
| HA2 |
pfam04408 |
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in ... |
459-548 |
4.10e-27 |
|
Helicase associated domain (HA2); This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 461295 [Multi-domain] Cd Length: 104 Bit Score: 105.78 E-value: 4.10e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 459 ALELLYALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEVLSIAAMMQIQNVFVFPSN------------ 526
Cdd:pfam04408 1 ALELLYYLGALDEDGELT-PLGRKMAELPLDPRLAKMLLAAAELGCLDEVLTIVAALSVRDPFVQPNFldprsaakaarr 79
|
90 100
....*....|....*....|....*
gi 21919420 527 -QKSQATRVHRKFAVE--EGDHLTM 548
Cdd:pfam04408 80 rRRAADEKARAKFARLdlEGDHLTL 104
|
|
| HA2 |
smart00847 |
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino ... |
465-549 |
3.19e-25 |
|
Helicase associated domain (HA2) Add an annotation; This presumed domain is about 90 amino acid residues in length. It is found is a diverse set of RNA helicases. Its function is unknown, however it seems likely to be involved in nucleic acid binding.
Pssm-ID: 214852 [Multi-domain] Cd Length: 82 Bit Score: 99.65 E-value: 3.19e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 465 ALGGLDKDCRLTePLGMRIAEFPLNPMFAKMLLESGNFGCSQEVLSIAAMMQIQNvfVFPSNQKSQATRVHRKFAVEEGD 544
Cdd:smart00847 1 ELGALDDDGRLT-PLGRKMAELPLDPRLAKMLLAAAEFGCLDEILTIVAMLSVGD--PRPKEKREDADAARRRFADPESD 77
|
....*
gi 21919420 545 HLTML 549
Cdd:smart00847 78 HLTLL 82
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
53-224 |
8.65e-19 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 85.24 E-value: 8.65e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 53 KLPVFKLRNH----ILYLVENYQTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVGVTQPRRVAAVTVAGRVADERGAVL 128
Cdd:smart00487 3 KFGFEPLRPYqkeaIEALLSGLRDVILAAPTGSGKTLAALLPALEALKRGKGGRVLVLVPTRELAEQWAEELKKLGPSLG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 129 GHEVGYC------IRFDDCTDPlATRIKFLTDGMLVREMMVDPL-LTKYSVIMLDEAHERT--LYTDIAIGLLKKIQKKR 199
Cdd:smart00487 83 LKVVGLYggdskrEQLRKLESG-KTDILVTTPGRLLDLLENDKLsLSNVDLVILDEAHRLLdgGFGDQLEKLLKLLPKNV 161
|
170 180
....*....|....*....|....*..
gi 21919420 200 gdlRLIVASATL--DAEKFRDFFNQNE 224
Cdd:smart00487 162 ---QLLLLSATPpeEIENLLELFLNDP 185
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
301-396 |
9.76e-14 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 66.85 E-value: 9.76e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 301 LARTGMKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVATNVAETSITISGIVYVIDCGFmklraynprtaieclvvv 380
Cdd:smart00490 3 LAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDL------------------ 64
|
90
....*....|....*.
gi 21919420 381 PVSQASANQRAGRGGR 396
Cdd:smart00490 65 PWSPASYIQRIGRAGR 80
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
262-396 |
1.40e-12 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 64.54 E-value: 1.40e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 262 VDTVVKIHQTEGDGDILAFLTGQEEVETvvSMLIEqaralartgmKKHLRVLPMYAGLPSFEQMKVFERVSHSVRKVIVA 341
Cdd:pfam00271 3 LEALLELLKKERGGKVLIFSQTKKTLEA--ELLLE----------KEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVA 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 21919420 342 TNVAETSITISGIVYVIDCGFmklrAYNPRTAIeclvvvpvsqasanQRAGRGGR 396
Cdd:pfam00271 71 TDVAERGLDLPDVDLVINYDL----PWNPASYI--------------QRIGRAGR 107
|
|
| PHA02653 |
PHA02653 |
RNA helicase NPH-II; Provisional |
41-407 |
8.83e-10 |
|
RNA helicase NPH-II; Provisional
Pssm-ID: 177443 [Multi-domain] Cd Length: 675 Bit Score: 61.92 E-value: 8.83e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 41 PYAALSIEQQRQKLPVFKLRNhilylvenyqTVVIVGETGCGKSTQIPQ------YLAeAGWTAEGRVVGVTQPRRVaaV 114
Cdd:PHA02653 160 PLASLQPDVQLKIFEAWISRK----------PVVLTGGTGVGKTSQVPKlllwfnYLF-GGFDNLDKIDPNFIERPI--V 226
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 115 TVAGRVADER--GAVLGHEVGY--------CIRFDDCTDPLA-TRIKFltDGMLVRemmVDPL----LTKYSVIMLDEAH 179
Cdd:PHA02653 227 LSLPRVALVRlhSITLLKSLGFdeidgspiSLKYGSIPDELInTNPKP--YGLVFS---THKLtlnkLFDYGTVIIDEVH 301
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 180 ERTLYTDIAIGLLKkiqKKRGDLR-LIVASATL--DAEKFRDFFNqnetsDPArdtsvTLTVEGRT-FPVDIFYL---QS 252
Cdd:PHA02653 302 EHDQIGDIIIAVAR---KHIDKIRsLFLMTATLedDRDRIKEFFP-----NPA-----FVHIPGGTlFPISEVYVknkYN 368
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 253 PvPD---YIKATVDTVVKIHQT----EGDGDILaFltgqeeVETvVSMLIEQARALartgmKKHLRVLPMY---AGLPSF 322
Cdd:PHA02653 369 P-KNkraYIEEEKKNIVTALKKytppKGSSGIV-F------VAS-VSQCEEYKKYL-----EKRLPIYDFYiihGKVPNI 434
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 323 EQM--KVF--ERVShsvrkVIVATNVAETSITISGIVYVIDCGfmklRAYNPRtaieclvvvP-------VSQASANQRA 391
Cdd:PHA02653 435 DEIleKVYssKNPS-----IIISTPYLESSVTIRNATHVYDTG----RVYVPE---------PfggkemfISKSMRTQRK 496
|
410
....*....|....*.
gi 21919420 392 GRGGRNRSGKCYRLYT 407
Cdd:PHA02653 497 GRVGRVSPGTYVYFYD 512
|
|
| OB_NTP_bind |
pfam07717 |
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus ... |
606-659 |
2.65e-09 |
|
Oligonucleotide/oligosaccharide-binding (OB)-fold; This family is found towards the C-terminus of the DEAD-box helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. There do seem to be a couple of instances where it occurs by itself -. The structure PDB:3i4u adopts an OB-fold. helicases (pfam00270). In these helicases it is apparently always found in association with pfam04408. This C-terminal domain of the yeast helicase contains an oligonucleotide/oligosaccharide-binding (OB)-fold which seems to be placed at the entrance of the putative nucleic acid cavity. It also constitutes the binding site for the G-patch-containing domain of Pfa1p. When found on DEAH/RHA helicases, this domain is central to the regulation of the helicase activity through its binding of both RNA and G-patch domain proteins.
Pssm-ID: 400182 [Multi-domain] Cd Length: 82 Bit Score: 54.18 E-value: 2.65e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 606 VLRCIVSGFFANAAR------------------FHSSGAYR---------VIYNEVIQTSKYYMRDVTAIESAWLLELAP 658
Cdd:pfam07717 1 LRAALAAGLYPNVARrdpkgkgyttlsdnqrvfIHPSSVLFnektfppewVVYQELVETTKVYIRTVTAISPEWLLLFAP 80
|
.
gi 21919420 659 H 659
Cdd:pfam07717 81 H 81
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
73-210 |
2.16e-07 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 50.48 E-value: 2.16e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 73 VVIVGETGCGKSTQIPQYLAEAGWTAEGRVVgVTQPRRVAAVTVAGRVADERG-----AVLGHEVGYCIRFDDCTDPLat 147
Cdd:cd00046 4 VLITAPTGSGKTLAALLAALLLLLKKGKKVL-VLVPTKALALQTAERLRELFGpgirvAVLVGGSSAEEREKNKLGDA-- 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21919420 148 RIKFLTDGMLVREMMVDPLLT--KYSVIMLDEAHeRTLYTD--IAIGLLKKIQKKRGDLRLIVASAT 210
Cdd:cd00046 81 DIIIATPDMLLNLLLREDRLFlkDLKLIIVDEAH-ALLIDSrgALILDLAVRKAGLKNAQVILLSAT 146
|
|
| DEXHc_viral_Ns3 |
cd17931 |
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional ... |
71-210 |
2.80e-06 |
|
DEXH-box helicase domain of NS3 protease-helicase; NS3 is a nonstructural multifunctional protein found in pestiviruses that contains an N-terminal protease and a C-terminal helicase. The N-terminal domain is a chymotrypsin-like serine protease, which is responsible for most of the maturation cleavages of the polyprotein precursor in the cytosolic side of the endoplasmic reticulum membrane. The C-terminal domain, about two-thirds of NS3, is a helicase belonging to superfamily 2 (SF2) thought to be important for unwinding highly structured regions of the RNA genome during replication. NS3 plays an essential role in viral polyprotein processing and genome replication. NS3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350689 [Multi-domain] Cd Length: 151 Bit Score: 47.54 E-value: 2.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 71 QTVVIVGETGCGKSTQIPQYLAEAGWTAEGRVVgVTQPRRVAAVTVAgrvADERGAVLGHEVGYCIRFDDCTDPlatrIK 150
Cdd:cd17931 2 QLTVLDLHPGAGKTTRVLPQIIREAIKKRLRTL-VLAPTRVVAAEMY---EALRGLPIRYRTGAVKEEHGGNEI----VD 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 151 FLTDGMLVREMMVDPLLTKYSVIMLDEAHERTLYTDIAIGLLKKiQKKRGDLRLIVASAT 210
Cdd:cd17931 74 YMCHGTFTCRLLSPKRVPNYNLIIMDEAHFTDPASIAARGYIHT-RVEMGEAAVIFMTAT 132
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
258-411 |
1.16e-03 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 42.17 E-value: 1.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 258 IKATVDTVVKIHQTEGDGDILAFLTGQEEVETVVSMLIE----------QARALARTGMKKHlrvlpmyaglpsfEQMKV 327
Cdd:PRK13766 349 LEKLREIVKEQLGKNPDSRIIVFTQYRDTAEKIVDLLEKegikavrfvgQASKDGDKGMSQK-------------EQIEI 415
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21919420 328 FERVSHSVRKVIVATNVAETSITISGIVYVIdcgFmklraYNPrtaieclvvVPvSQASANQRAGRGGRNRSGKCYRLYT 407
Cdd:PRK13766 416 LDKFRAGEFNVLVSTSVAEEGLDIPSVDLVI---F-----YEP---------VP-SEIRSIQRKGRTGRQEEGRVVVLIA 477
|
....*...
gi 21919420 408 E----EAF 411
Cdd:PRK13766 478 KgtrdEAY 485
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
337-406 |
1.92e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 37.68 E-value: 1.92e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 21919420 337 KVIVATNVAETSITISGIVYVIDCGfmklraynprtaieclvvVPVSQASANQRAGRGGRN--RSGKCYRLY 406
Cdd:cd18785 24 EILVATNVLGEGIDVPSLDTVIFFD------------------PPSSAASYIQRVGRAGRGgkDEGEVILFV 77
|
|
| |
