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Conserved domains on  [gi|22122643|ref|NP_666237|]
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inositol-trisphosphate 3-kinase A [Mus musculus]

Protein Classification

inositol polyphosphate kinase family protein (domain architecture ID 10510177)

inositol polyphosphate kinase family protein such as inositol hexakisphosphate kinase, which converts inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5) and 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IPK pfam03770
Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol ...
243-453 1.82e-59

Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.


:

Pssm-ID: 397715  Cd Length: 190  Bit Score: 193.16  E-value: 1.82e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122643   243 YLQLQDLLDGFDGPCVLDCKMGVRTYleeeltkarerpklrkdmykkmlavDPEAPTEeehaqravtKPRYMQWREGISS 322
Cdd:pfam03770   1 YILLEDLTAGFKKPCVLDLKMGTRTY-------------------------GDDASEE---------KRRRQQKKCRETT 46
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122643   323 STTLGFRIEGIK----KADG--SCSTDFKTTRSREQVTRVFEEFMQ------GDAEVLRRYLNRLQQIRDTLEISDFFRr 390
Cdd:pfam03770  47 SASLGFRICGMKvwnvDTDGyiFRDKYYGRSLSAEEFKEALKRFFSngkslrRKKKIIPRFLERLQELRNVLESQESYR- 125
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22122643   391 heVIGSSLLFVHDHC---------HRAGVWLIDFGKTTPLPDGqildhrRPWEEGNREDGYLLGLDNLIGIL 453
Cdd:pfam03770 126 --FYSSSLLFVYDGDpesaeedppPKVKVKLIDFAHTVPLPDG------PPWPGGGPDEGYLFGLRSLIKIL 189
 
Name Accession Description Interval E-value
IPK pfam03770
Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol ...
243-453 1.82e-59

Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.


Pssm-ID: 397715  Cd Length: 190  Bit Score: 193.16  E-value: 1.82e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122643   243 YLQLQDLLDGFDGPCVLDCKMGVRTYleeeltkarerpklrkdmykkmlavDPEAPTEeehaqravtKPRYMQWREGISS 322
Cdd:pfam03770   1 YILLEDLTAGFKKPCVLDLKMGTRTY-------------------------GDDASEE---------KRRRQQKKCRETT 46
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122643   323 STTLGFRIEGIK----KADG--SCSTDFKTTRSREQVTRVFEEFMQ------GDAEVLRRYLNRLQQIRDTLEISDFFRr 390
Cdd:pfam03770  47 SASLGFRICGMKvwnvDTDGyiFRDKYYGRSLSAEEFKEALKRFFSngkslrRKKKIIPRFLERLQELRNVLESQESYR- 125
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22122643   391 heVIGSSLLFVHDHC---------HRAGVWLIDFGKTTPLPDGqildhrRPWEEGNREDGYLLGLDNLIGIL 453
Cdd:pfam03770 126 --FYSSSLLFVYDGDpesaeedppPKVKVKLIDFAHTVPLPDG------PPWPGGGPDEGYLFGLRSLIKIL 189
PLN02667 PLN02667
inositol polyphosphate multikinase
188-429 1.17e-13

inositol polyphosphate multikinase


Pssm-ID: 215359  Cd Length: 286  Bit Score: 70.91  E-value: 1.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122643  188 QLAGHTGSFKAAGT----SGLILK------RSS-EPEHYCLVRLMADV---LRGCVPAFHGIVE---RDGESYLQLQDLL 250
Cdd:PLN02667   8 QVAGHRASDGKLGPlvddSGRFYKplqddsRGErEAAFYESFSSDTRVpdhIRRFFPVFHGTQLveaSDGSGLLVLEDLL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122643  251 DGFDGPCVLDCKMGVRTYleeeltkarerpklrkdmYkkmlavdPEAPteEEHAQRAVTKPRymqwregISSSTTLGFRI 330
Cdd:PLN02667  88 AGYTKPCVMDVKMGSRTW------------------Y-------PEAS--EEYIQKCLKKDR-------ETTTVSLGFRV 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122643  331 EGIKKADGSCSTDFKTTRSREQVTRVfeefmQGDAEVLRRYLNR-----------------------LQQIRdtlEISDF 387
Cdd:PLN02667 134 SGFKVYDHKESEFWKAERKLVKGLDA-----DGVRLALRKFVSSnspadpnpdcafasavyggshgiLAQLL---ELKSW 205
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 22122643  388 F---RRHEVIGSSLLFVHD-HCHRAG--------VWLIDFGKTTplPDGQILDH 429
Cdd:PLN02667 206 FeeqTLYHFFSASILIVYEgEAILKGnpedsrveVKLVDFAHVL--DGNGVIDH 257
 
Name Accession Description Interval E-value
IPK pfam03770
Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol ...
243-453 1.82e-59

Inositol polyphosphate kinase; ArgRIII has has been demonstrated to be an inositol polyphosphate kinase.


Pssm-ID: 397715  Cd Length: 190  Bit Score: 193.16  E-value: 1.82e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122643   243 YLQLQDLLDGFDGPCVLDCKMGVRTYleeeltkarerpklrkdmykkmlavDPEAPTEeehaqravtKPRYMQWREGISS 322
Cdd:pfam03770   1 YILLEDLTAGFKKPCVLDLKMGTRTY-------------------------GDDASEE---------KRRRQQKKCRETT 46
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122643   323 STTLGFRIEGIK----KADG--SCSTDFKTTRSREQVTRVFEEFMQ------GDAEVLRRYLNRLQQIRDTLEISDFFRr 390
Cdd:pfam03770  47 SASLGFRICGMKvwnvDTDGyiFRDKYYGRSLSAEEFKEALKRFFSngkslrRKKKIIPRFLERLQELRNVLESQESYR- 125
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 22122643   391 heVIGSSLLFVHDHC---------HRAGVWLIDFGKTTPLPDGqildhrRPWEEGNREDGYLLGLDNLIGIL 453
Cdd:pfam03770 126 --FYSSSLLFVYDGDpesaeedppPKVKVKLIDFAHTVPLPDG------PPWPGGGPDEGYLFGLRSLIKIL 189
PLN02667 PLN02667
inositol polyphosphate multikinase
188-429 1.17e-13

inositol polyphosphate multikinase


Pssm-ID: 215359  Cd Length: 286  Bit Score: 70.91  E-value: 1.17e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122643  188 QLAGHTGSFKAAGT----SGLILK------RSS-EPEHYCLVRLMADV---LRGCVPAFHGIVE---RDGESYLQLQDLL 250
Cdd:PLN02667   8 QVAGHRASDGKLGPlvddSGRFYKplqddsRGErEAAFYESFSSDTRVpdhIRRFFPVFHGTQLveaSDGSGLLVLEDLL 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122643  251 DGFDGPCVLDCKMGVRTYleeeltkarerpklrkdmYkkmlavdPEAPteEEHAQRAVTKPRymqwregISSSTTLGFRI 330
Cdd:PLN02667  88 AGYTKPCVMDVKMGSRTW------------------Y-------PEAS--EEYIQKCLKKDR-------ETTTVSLGFRV 133
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122643  331 EGIKKADGSCSTDFKTTRSREQVTRVfeefmQGDAEVLRRYLNR-----------------------LQQIRdtlEISDF 387
Cdd:PLN02667 134 SGFKVYDHKESEFWKAERKLVKGLDA-----DGVRLALRKFVSSnspadpnpdcafasavyggshgiLAQLL---ELKSW 205
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 22122643  388 F---RRHEVIGSSLLFVHD-HCHRAG--------VWLIDFGKTTplPDGQILDH 429
Cdd:PLN02667 206 FeeqTLYHFFSASILIVYEgEAILKGnpedsrveVKLVDFAHVL--DGNGVIDH 257
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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