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Conserved domains on  [gi|22122705|ref|NP_666279|]
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GTPase, IMAP family member 7 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 9-209 9.85e-105

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


:

Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 303.30  E-value: 9.85e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705   9 LRIVLVGKTGSGKSATANTILGQKRFVSRIAPHAVTQNCQSDSRRWKERDLLVVDTPGLFDTKVKLETTCLEISRCVLQS 88
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705  89 CPGPHAIILVLQLNRFTVEEQETVIRIKAIFGEEVMKYMIVLFTRKDDLEDQSLSDFIADSDTNLKSIIKECGNRCLAIN 168
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCEALKRLLEKCGGRYVAFN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 22122705 169 NKAERAERETQVQELMGLVETLVQNNGGLYFSHPVYKDAER 209
Cdd:cd01852 161 NKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
OmpH super family cl33403
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 197-288 4.32e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


The actual alignment was detected with superfamily member smart00935:

Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 39.49  E-value: 4.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705    197 LYFSHPVYKDAERRLKKQVEILRKIYTDLpEKEIRIVEEEY-----ALRKFSAQEREKKIQAIRENYNLKIRNLREEAEK 271
Cdd:smart00935   9 ILQESPAGKAAQKQLEKEFKKRQAELEKL-EKELQKLKEKLqkdaaTLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQK 87

                           90       100
                   ....*....|....*....|
gi 22122705    272 ---NIFNQIIEEVKKVLLKI 288
Cdd:smart00935  88 rqqEELQKILDKINKAIKEV 107
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 9-209 9.85e-105

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 303.30  E-value: 9.85e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705   9 LRIVLVGKTGSGKSATANTILGQKRFVSRIAPHAVTQNCQSDSRRWKERDLLVVDTPGLFDTKVKLETTCLEISRCVLQS 88
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705  89 CPGPHAIILVLQLNRFTVEEQETVIRIKAIFGEEVMKYMIVLFTRKDDLEDQSLSDFIADSDTNLKSIIKECGNRCLAIN 168
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCEALKRLLEKCGGRYVAFN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 22122705 169 NKAERAERETQVQELMGLVETLVQNNGGLYFSHPVYKDAER 209
Cdd:cd01852 161 NKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 9-213 7.61e-95

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 278.34  E-value: 7.61e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705     9 LRIVLVGKTGSGKSATANTILGQKRFVSRIAPHAVTQNCQSDSRRWKERDLLVVDTPGLFDTKVKLETTCLEISRCVLQS 88
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705    89 CPGPHAIILVLQLNRFTVEEQETVIRIKAIFGEEVMKYMIVLFTRKDDLEDQSLSDFIADSD-TNLKSIIKEcgnrclai 167
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCpEFLKEVLRT-------- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 22122705   168 nnkAERAERETQVQELMGLVETLVQNNGGLYFSHPVYKDAERRLKK 213
Cdd:pfam04548 153 ---ADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIKEEGER 195
YeeP COG3596
Predicted GTPase [General function prediction only];
9-138 1.91e-08

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 54.39  E-value: 1.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705   9 LRIVLVGKTGSGKSATANTILGQKRF-VSRIAPH-AVTQNCqsdsrRWKERD---LLVVDTPGLFDTKVKLETTcleisR 83
Cdd:COG3596  40 PVIALVGKTGAGKSSLINALFGAEVAeVGVGRPCtREIQRY-----RLESDGlpgLVLLDTPGLGEVNERDREY-----R 109

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22122705  84 CVLQSCPGPHAIILVLQ-LNRFTVEEQETVIRIKAIFGEEVmkyMIVLFTRKDDLE 138
Cdd:COG3596 110 ELRELLPEADLILWVVKaDDRALATDEEFLQALRAQYPDPP---VLVVLTQVDRLE 162
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 3-132 1.90e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 49.18  E-value: 1.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705     3 EPSDNSLRIVLVGKTGSGKSATANTILGQKRFvSRIAPHAVTQNCQSDSRRWKERDLLVVDTPGLFDTKVKLETT--CLE 80
Cdd:TIGR00993 113 DPLDFSLNILVLGKSGVGKSATINSIFGEVKF-STDAFGMGTTSVQEIEGLVQGVKIRVIDTPGLKSSASDQSKNekILS 191

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 22122705    81 ISRCVLQSCPgPHaiiLVLQLNRFTVEEQET----VIR-IKAIFGEEVMKYMIVLFT 132
Cdd:TIGR00993 192 SVKKFIKKNP-PD---IVLYVDRLDMQTRDSndlpLLRtITDVLGPSIWFNAIVTLT 244
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 197-288 4.32e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 39.49  E-value: 4.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705    197 LYFSHPVYKDAERRLKKQVEILRKIYTDLpEKEIRIVEEEY-----ALRKFSAQEREKKIQAIRENYNLKIRNLREEAEK 271
Cdd:smart00935   9 ILQESPAGKAAQKQLEKEFKKRQAELEKL-EKELQKLKEKLqkdaaTLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQK 87

                           90       100
                   ....*....|....*....|
gi 22122705    272 ---NIFNQIIEEVKKVLLKI 288
Cdd:smart00935  88 rqqEELQKILDKINKAIKEV 107
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
 197-288 7.03e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 39.43  E-value: 7.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705 197 LYFSHPVYKDAERRLKKQVEILRKIYTDLpEKEIRIVEEEY-----ALRKFSAQEREKKIQAIRENYNLKIRNLREE--- 268
Cdd:COG2825  34 ILQESPEGKAAQKKLEKEFKKRQAELQKL-EKELQALQEKLqkeaaTLSEEERQKKERELQKKQQELQRKQQEAQQDlqk 112

                        90       100
                ....*....|....*....|
gi 22122705 269 AEKNIFNQIIEEVKKVLLKI 288
Cdd:COG2825 113 RQQELLQPILEKIQKAIKEV 132
 
Name Accession Description Interval E-value
AIG1 cd01852
AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 ...
 9-209 9.85e-105

AvrRpt2-Induced Gene 1 (AIG1); This group represents Arabidoposis protein AIG1 (avrRpt2-induced gene 1) that appears to be involved in plant resistance to bacteria. The Arabidopsis disease resistance gene RPS2 is involved in recognition of bacterial pathogens carrying the avirulence gene avrRpt2. AIG1 exhibits RPS2- and avrRpt1-dependent induction early after infection with Pseudomonas syringae carrying avrRpt2. This subfamily also includes IAN-4 protein, which has GTP-binding activity and shares sequence homology with a novel family of putative GTP-binding proteins: the immuno-associated nucleotide (IAN) family. The evolutionary conservation of the IAN family provides a unique example of a plant pathogen response gene conserved in animals. The IAN/IMAP subfamily has been proposed to regulate apoptosis in vertebrates and angiosperm plants, particularly in relation to cancer, diabetes, and infections. The human IAN genes were renamed GIMAP (GTPase of the immunity associated proteins).


Pssm-ID: 206651 [Multi-domain]  Cd Length: 201  Bit Score: 303.30  E-value: 9.85e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705   9 LRIVLVGKTGSGKSATANTILGQKRFVSRIAPHAVTQNCQSDSRRWKERDLLVVDTPGLFDTKVKLETTCLEISRCVLQS 88
Cdd:cd01852   1 LRLVLVGKTGNGKSATGNTILGRKVFESKLSASGVTKTCQKESAVWDGRRVNVIDTPGLFDTSVSPEQLSKEIIRCLSLS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705  89 CPGPHAIILVLQLNRFTVEEQETVIRIKAIFGEEVMKYMIVLFTRKDDLEDQSLSDFIADSDTNLKSIIKECGNRCLAIN 168
Cdd:cd01852  81 APGPHAFLLVVPLGRFTEEEEQAVEELQELFGEKVLDHTIVLFTRGDDLEGGSLEDYLEDSCEALKRLLEKCGGRYVAFN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 22122705 169 NKAERAERETQVQELMGLVETLVQNNGGLYFSHPVYKDAER 209
Cdd:cd01852 161 NKAKGREQEQQVKELLAKVEEMVRENGGKPYTNEMYEEAEE 201
AIG1 pfam04548
AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.
 9-213 7.61e-95

AIG1 family; Arabidopsis protein AIG1 appears to be involved in plant resistance to bacteria.


Pssm-ID: 398307 [Multi-domain]  Cd Length: 200  Bit Score: 278.34  E-value: 7.61e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705     9 LRIVLVGKTGSGKSATANTILGQKRFVSRIAPHAVTQNCQSDSRRWKERDLLVVDTPGLFDTKVKLETTCLEISRCVLQS 88
Cdd:pfam04548   1 LRIVLVGKTGNGKSATGNSILGRKAFESKLRAQGVTKTCQLVSRTWDGRIINVIDTPGLFDLSVSNDFISKEIIRCLLLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705    89 CPGPHAIILVLQLNRFTVEEQETVIRIKAIFGEEVMKYMIVLFTRKDDLEDQSLSDFIADSD-TNLKSIIKEcgnrclai 167
Cdd:pfam04548  81 EPGPHAVLLVLSLGRFTEEEEQALRTLQELFGSKILDYMIVVFTRKDDLEDDSLDDYLSDGCpEFLKEVLRT-------- 152

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 22122705   168 nnkAERAERETQVQELMGLVETLVQNNGGLYFSHPVYKDAERRLKK 213
Cdd:pfam04548 153 ---ADGEEKEEQVQQLLALVEAIVKENGGKPYTNDLYEKIKEEGER 195
Ras_like_GTPase cd00882
Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like ...
 12-170 2.39e-11

Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras, Rho, Rab, and Sar1/Arf families. This superfamily also includes proteins like the GTP translation factors, Era-like GTPases, and G-alpha chain of the heterotrimeric G proteins. Members of the Ras superfamily regulate a wide variety of cellular functions: the Ras family regulates gene expression, the Rho family regulates cytoskeletal reorganization and gene expression, the Rab and Sar1/Arf families regulate vesicle trafficking, and the Ran family regulates nucleocytoplasmic transport and microtubule organization. The GTP translation factor family regulates initiation, elongation, termination, and release in translation, and the Era-like GTPase family regulates cell division, sporulation, and DNA replication. Members of the Ras superfamily are identified by the GTP binding site, which is made up of five characteristic sequence motifs, and the switch I and switch II regions.


Pssm-ID: 206648 [Multi-domain]  Cd Length: 161  Bit Score: 60.93  E-value: 2.39e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705  12 VLVGKTGSGKSATANTILGQKRFVSRIAPHaVTQNCQSDSRRW--KERDLLVVDTPGLFDTKVklettcLEISRCVLQSC 89
Cdd:cd00882   1 VVVGRGGVGKSSLLNALLGGEVGEVSDVPG-TTRDPDVYVKELdkGKVKLVLVDTPGLDEFGG------LGREELARLLL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705  90 PGPHAIILVLQLNRFTVEEQETVIRIKAIFGEEvmKYMIVLFTRKDDLEDQSLsdfiaDSDTNLKSIIKECGNRCLAINN 169
Cdd:cd00882  74 RGADLILLVVDSTDRESEEDAKLLILRRLRKEG--IPIILVGNKIDLLEEREV-----EELLRLEELAKILGVPVFEVSA 146


                .
gi 22122705 170 K 170
Cdd:cd00882 147 K 147
Toc34_like cd01853
Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like ...
 3-132 2.14e-10

Translocon at the Outer-envelope membrane of Chloroplasts 34-like (Toc34-like); The Toc34-like (Translocon at the Outer-envelope membrane of Chloroplasts) family contains several Toc proteins, including Toc34, Toc33, Toc120, Toc159, Toc86, Toc125, and Toc90. The Toc complex at the outer envelope membrane of chloroplasts is a molecular machine of ~500 kDa that contains a single Toc159 protein, four Toc75 molecules, and four or five copies of Toc34. Toc64 and Toc12 are associated with the translocon, but do not appear to be part of the core complex. The Toc translocon initiates the import of nuclear-encoded preproteins from the cytosol into the organelle. Toc34 and Toc159 are both GTPases, while Toc75 is a beta-barrel integral membrane protein. Toc159 is equally distributed between a soluble cytoplasmic form and a membrane-inserted form, suggesting that assembly of the Toc complex is dynamic. Toc34 and Toc75 act sequentially to mediate docking and insertion of Toc159 resulting in assembly of the functional translocon.


Pssm-ID: 206652  Cd Length: 248  Bit Score: 59.64  E-value: 2.14e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705   3 EPSDNSLRIVLVGKTGSGKSATANTILGQkRFVSRIAPHAVTQNCQSDSRRWKERDLLVVDTPGLFDTKVKL-ETTCLEI 81
Cdd:cd01853  26 KELDFSLTILVLGKTGVGKSSTINSIFGE-RKVSVSAFQSETLRPREVSRTVDGFKLNIIDTPGLLESQDQRvNRKILSI 104

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 22122705  82 SRCVLQSCPgPHAIILVLQLNRFTVEEQE-TVIR-IKAIFGEEVMKYMIVLFT 132
Cdd:cd01853 105 IKRFLKKKT-IDVVLYVDRLDMYRVDNLDvPLLRaITDSFGPSIWRNAIVVLT 156
MMR_HSR1 pfam01926
50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete ...
 10-133 8.18e-09

50S ribosome-binding GTPase; The full-length GTPase protein is required for the complete activity of the protein of interacting with the 50S ribosome and binding of both adenine and guanine nucleotides, with a preference for guanine nucleotide.


Pssm-ID: 460387 [Multi-domain]  Cd Length: 113  Bit Score: 52.62  E-value: 8.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705    10 RIVLVGKTGSGKSATANTILGQKRFVSRIAPhaVTQNCQSDSRRWKERDLLVVDTPGLFDTKVK---LETTCLEISRCvl 86
Cdd:pfam01926   1 RVALVGRPNVGKSTLINALTGAKAIVSDYPG--TTRDPNEGRLELKGKQIILVDTPGLIEGASEgegLGRAFLAIIEA-- 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 22122705    87 qscpgpHAIILVLQLNRFTVEEQETVIRikaiFGEEVMKYMIVLFTR 133
Cdd:pfam01926  77 ------DLILFVVDSEEGITPLDEELLE----LLRENKKPIILVLNK 113
YeeP COG3596
Predicted GTPase [General function prediction only];
9-138 1.91e-08

Predicted GTPase [General function prediction only];


Pssm-ID: 442815 [Multi-domain]  Cd Length: 318  Bit Score: 54.39  E-value: 1.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705   9 LRIVLVGKTGSGKSATANTILGQKRF-VSRIAPH-AVTQNCqsdsrRWKERD---LLVVDTPGLFDTKVKLETTcleisR 83
Cdd:COG3596  40 PVIALVGKTGAGKSSLINALFGAEVAeVGVGRPCtREIQRY-----RLESDGlpgLVLLDTPGLGEVNERDREY-----R 109

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 22122705  84 CVLQSCPGPHAIILVLQ-LNRFTVEEQETVIRIKAIFGEEVmkyMIVLFTRKDDLE 138
Cdd:COG3596 110 ELRELLPEADLILWVVKaDDRALATDEEFLQALRAQYPDPP---VLVVLTQVDRLE 162
Era_like cd00880
E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family ...
 12-183 2.93e-08

E. coli Ras-like protein (Era)-like GTPase; The Era (E. coli Ras-like protein)-like family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngB), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs), to the exclusion of other GTPases. TrmE is ubiquitous in bacteria and is a widespread mitochondrial protein in eukaryotes, but is absent from archaea. The yeast member of TrmE family, MSS1, is involved in mitochondrial translation; bacterial members are often present in translation-related operons. FeoB represents an unusual adaptation of GTPases for high-affinity iron (II) transport. YihA (EngB) family of GTPases is typified by the E. coli YihA, which is an essential protein involved in cell division control. Era is characterized by a distinct derivative of the KH domain (the pseudo-KH domain) which is located C-terminal to the GTPase domain. EngA and its orthologs are composed of two GTPase domains and, since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family.


Pssm-ID: 206646 [Multi-domain]  Cd Length: 161  Bit Score: 52.25  E-value: 2.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705  12 VLVGKTGSGKSATANTILGQKRF-VSRIapHAVTQNcqSDSRRW---KERDLLVVDTPGLFDTKVKLETTCLEISRcVLQ 87
Cdd:cd00880   1 AIFGRPNVGKSSLLNALLGQNVGiVSPI--PGTTRD--PVRKEWellPLGPVVLIDTPGLDEEGGLGRERVEEARQ-VAD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705  88 SCpgpHAIILVLQLNRFTVEEQETVIRIkaifgEEVMKYMIVLFTrKDDLEDQSLSDFIADSDTNLKSIikecGNRCLAI 167
Cdd:cd00880  76 RA---DLVLLVVDSDLTPVEEEAKLGLL-----RERGKPVLLVLN-KIDLVPESEEEELLRERKLELLP----DLPVIAV 142

                       170
                ....*....|....*.
gi 22122705 168 NnkaerAERETQVQEL 183
Cdd:cd00880 143 S-----ALPGEGIDEL 153
3a0901s04IAP86 TIGR00993
chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K ...
 3-132 1.90e-06

chloroplast protein import component Toc86/159, G and M domains; The long precursor of the 86K protein originally described is proposed to have three domains. The N-terminal A-domain is acidic, repetitive, weakly conserved, readily removed by proteolysis during chloroplast isolation, and not required for protein translocation. The other domains are designated G (GTPase) and M (membrane anchor); this family includes most of the G domain and all of M. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273381 [Multi-domain]  Cd Length: 763  Bit Score: 49.18  E-value: 1.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705     3 EPSDNSLRIVLVGKTGSGKSATANTILGQKRFvSRIAPHAVTQNCQSDSRRWKERDLLVVDTPGLFDTKVKLETT--CLE 80
Cdd:TIGR00993 113 DPLDFSLNILVLGKSGVGKSATINSIFGEVKF-STDAFGMGTTSVQEIEGLVQGVKIRVIDTPGLKSSASDQSKNekILS 191

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 22122705    81 ISRCVLQSCPgPHaiiLVLQLNRFTVEEQET----VIR-IKAIFGEEVMKYMIVLFT 132
Cdd:TIGR00993 192 SVKKFIKKNP-PD---IVLYVDRLDMQTRDSndlpLLRtITDVLGPSIWFNAIVTLT 244
3a0901s02IAP34 TIGR00991
GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding ...
 7-132 1.68e-04

GTP-binding protein (Chloroplast Envelope Protein Translocase); [Transport and binding proteins, Nucleosides, purines and pyrimidines]


Pssm-ID: 130064  Cd Length: 313  Bit Score: 42.58  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705     7 NSLRIVLVGKTGSGKSATANTILGQKrfVSRIAPHavtqncQSD-------SRRWKERDLLVVDTPGLFDTKVKLETTCL 79
Cdd:TIGR00991  37 SSLTILVMGKGGVGKSSTVNSIIGER--IATVSAF------QSEglrpmmvSRTRAGFTLNIIDTPGLIEGGYINDQAVN 108

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 22122705    80 EISRCVLQScpgphAIILVLQLNRFTVEEQETVIR--IKAI---FGEEVMKYMIVLFT 132
Cdd:TIGR00991 109 IIKRFLLGK-----TIDVLLYVDRLDAYRVDTLDGqvIRAItdsFGKDIWRKSLVVLT 161
DLP_2 cd09912
Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; The ...
 9-144 3.73e-04

Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; The dynamin family of large mechanochemical GTPases includes the classical dynamins and dynamin-like proteins (DLPs) that are found throughout the Eukarya. This family also includes bacterial DLPs. These proteins catalyze membrane fission during clathrin-mediated endocytosis. Dynamin consists of five domains; an N-terminal G domain that binds and hydrolyzes GTP, a middle domain (MD) involved in self-assembly and oligomerization, a pleckstrin homology (PH) domain responsible for interactions with the plasma membrane, GED, which is also involved in self-assembly, and a proline arginine rich domain (PRD) that interacts with SH3 domains on accessory proteins. To date, three vertebrate dynamin genes have been identified; dynamin 1, which is brain specific, mediates uptake of synaptic vesicles in presynaptic terminals; dynamin-2 is expressed ubiquitously and similarly participates in membrane fission; mutations in the MD, PH and GED domains of dynamin 2 have been linked to human diseases such as Charcot-Marie-Tooth peripheral neuropathy and rare forms of centronuclear myopathy. Dynamin 3 participates in megakaryocyte progenitor amplification, and is also involved in cytoplasmic enlargement and the formation of the demarcation membrane system. This family also includes mitofusins (MFN1 and MFN2 in mammals) that are involved in mitochondrial fusion. Dynamin oligomerizes into helical structures around the neck of budding vesicles in a GTP hydrolysis-dependent manner.


Pssm-ID: 206739 [Multi-domain]  Cd Length: 180  Bit Score: 40.61  E-value: 3.73e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705   9 LRIVLVGKTGSGKSATANTILGQKRFVSRIAPhaVTQNCQSDSRRWKeRDLLVVDTPGLFDTKVKLEttclEISRCVLQS 88
Cdd:cd09912   1 FLLAVVGEFSAGKSTLLNALLGEEVLPTGVTP--TTAVITVLRYGLL-KGVVLVDTPGLNSTIEHHT----EITESFLPR 73

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 22122705  89 CpgpHAIILVLQLNR-FTVEEQETVIRIKAIFGeevmKYMIVLFTRKDDLEDQSLSD 144
Cdd:cd09912  74 A---DAVIFVLSADQpLTESEREFLKEILKWSG----KKIFFVLNKIDLLSEEELEE 123
OmpH smart00935
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 197-288 4.32e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 214922 [Multi-domain]  Cd Length: 140  Bit Score: 39.49  E-value: 4.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705    197 LYFSHPVYKDAERRLKKQVEILRKIYTDLpEKEIRIVEEEY-----ALRKFSAQEREKKIQAIRENYNLKIRNLREEAEK 271
Cdd:smart00935   9 ILQESPAGKAAQKQLEKEFKKRQAELEKL-EKELQKLKEKLqkdaaTLSEAAREKKEKELQKKVQEFQRKQQKLQQDLQK 87

                           90       100
                   ....*....|....*....|
gi 22122705    272 ---NIFNQIIEEVKKVLLKI 288
Cdd:smart00935  88 rqqEELQKILDKINKAIKEV 107
small_GTP TIGR00231
small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this ...
 10-148 5.74e-04

small GTP-binding protein domain; Proteins with a small GTP-binding domain recognized by this model include Ras, RhoA, Rab11, translation elongation factor G, translation initiation factor IF-2, tetratcycline resistance protein TetM, CDC42, Era, ADP-ribosylation factors, tdhF, and many others. In some proteins the domain occurs more than once.This model recognizes a large number of small GTP-binding proteins and related domains in larger proteins. Note that the alpha chains of heterotrimeric G proteins are larger proteins in which the NKXD motif is separated from the GxxxxGK[ST] motif (P-loop) by a long insert and are not easily detected by this model. [Unknown function, General]


Pssm-ID: 272973 [Multi-domain]  Cd Length: 162  Bit Score: 39.66  E-value: 5.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705    10 RIVLVGKTGSGKSATANTILGQKRFVSRIAP----HAVTQNCQSDSRRWKerdLLVVDTPG--LFDTKVKLETTCLEISR 83
Cdd:TIGR00231   3 KIVIVGHPNVGKSTLLNSLLGNKGSITEYYPgttrNYVTTVIEEDGKTYK---FNLLDTAGqeDYDAIRRLYYPQVERSL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22122705    84 CVLQScpgphaIILVLQLNRfTVEEQEtviriKAIFGEEVMKYMIVLFTRKDDLEDQSLSDFIAD 148
Cdd:TIGR00231  80 RVFDI------VILVLDVEE-ILEKQT-----KEIIHHADSGVPIILVGNKIDLKDADLKTHVAS 132
HlpA COG2825
Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope ...
 197-288 7.03e-04

Periplasmic chaperone for outer membrane proteins, Skp family [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 442073 [Multi-domain]  Cd Length: 171  Bit Score: 39.43  E-value: 7.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22122705 197 LYFSHPVYKDAERRLKKQVEILRKIYTDLpEKEIRIVEEEY-----ALRKFSAQEREKKIQAIRENYNLKIRNLREE--- 268
Cdd:COG2825  34 ILQESPEGKAAQKKLEKEFKKRQAELQKL-EKELQALQEKLqkeaaTLSEEERQKKERELQKKQQELQRKQQEAQQDlqk 112

                        90       100
                ....*....|....*....|
gi 22122705 269 AEKNIFNQIIEEVKKVLLKI 288
Cdd:COG2825 113 RQQELLQPILEKIQKAIKEV 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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