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Conserved domains on  [gi|22296603|ref|NP_680087|]
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COMM domain-containing protein 3 [Mus musculus]

Protein Classification

COMM domain-containing protein 3( domain architecture ID 10140830)

COMM domain-containing protein 3 (COMMD3) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes, down-regulate activation of NF-kappa-B, and modulate Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits

Gene Symbol:  COMMD3
Gene Ontology:  GO:0006814
PubMed:  15799966
SCOP:  4005215

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Commd3 cd04751
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of ...
 98-194 6.00e-44

COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240099  Cd Length: 95  Bit Score: 141.33  E-value: 6.00e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22296603  98 ELFCTEYQNNKNSLETLLGSIGRSLPHITDVSWRLEYQIKTNQLHKMYRPGYLVTLNVENNDsqSYPEINFSCNMEQLQD 177
Cdd:cd04751   1 EIFAKQYQKKKEVLENKLKSIGISFPHITDVNWRLDYVVSSKHLGKVNQPIYLIQLSTENGE--NKPDINFTCTLEQLQD 78

                        90
                ....*....|....*..
gi 22296603 178 LVGKLKDASKSLERATQ 194
Cdd:cd04751  79 LVNKLKDAAKNIERAAQ 95
 
Name Accession Description Interval E-value
Commd3 cd04751
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of ...
 98-194 6.00e-44

COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240099  Cd Length: 95  Bit Score: 141.33  E-value: 6.00e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22296603  98 ELFCTEYQNNKNSLETLLGSIGRSLPHITDVSWRLEYQIKTNQLHKMYRPGYLVTLNVENNDsqSYPEINFSCNMEQLQD 177
Cdd:cd04751   1 EIFAKQYQKKKEVLENKLKSIGISFPHITDVNWRLDYVVSSKHLGKVNQPIYLIQLSTENGE--NKPDINFTCTLEQLQD 78

                        90
                ....*....|....*..
gi 22296603 178 LVGKLKDASKSLERATQ 194
Cdd:cd04751  79 LVNKLKDAAKNIERAAQ 95
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 121-185 1.05e-15

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 68.34  E-value: 1.05e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22296603   121 SLPHITDVSWRLEYQIKTNQLHKMYRPGYLVTLNVENNDSQSyPEINFSCNMEQLQDLVGKLKDA 185
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGSS-EEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd3 cd04751
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of ...
 98-194 6.00e-44

COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240099  Cd Length: 95  Bit Score: 141.33  E-value: 6.00e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22296603  98 ELFCTEYQNNKNSLETLLGSIGRSLPHITDVSWRLEYQIKTNQLHKMYRPGYLVTLNVENNDsqSYPEINFSCNMEQLQD 177
Cdd:cd04751   1 EIFAKQYQKKKEVLENKLKSIGISFPHITDVNWRLDYVVSSKHLGKVNQPIYLIQLSTENGE--NKPDINFTCTLEQLQD 78

                        90
                ....*....|....*..
gi 22296603 178 LVGKLKDASKSLERATQ 194
Cdd:cd04751  79 LVNKLKDAAKNIERAAQ 95
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 104-189 5.53e-16

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 69.65  E-value: 5.53e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22296603 104 YQNNKNSLETLLGSIGRSLPHITDVSWRLEYQIKTNQLHKMYRPGYLVTLNVENNDSQSYPEINFSCNMEQLQDLVGKLK 183
Cdd:cd04748   2 LTENKAEIEELLSKQSLSLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGDNNSSEKICFEMTKEELQNFLNKLK 81


                ....*.
gi 22296603 184 DASKSL 189
Cdd:cd04748  82 KIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 121-185 1.05e-15

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 68.34  E-value: 1.05e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 22296603   121 SLPHITDVSWRLEYQIKTNQLHKMYRPGYLVTLNVENNDSQSyPEINFSCNMEQLQDLVGKLKDA 185
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGSS-EEVTFELSKEQLQDLLNELEEA 64
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 64-185 9.76e-09

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 52.43  E-value: 9.76e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22296603  64 AAAATCILEAGKHQVDKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLETLLGSIGRSLPHITDVSWRLEYQIKTNQLHK 143
Cdd:cd04752  46 AVLSFILSSAAKYNVDGESLSSELQQLGLPKEHATSLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQE 125

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 22296603 144 MYRPGYLVTLNVENNDSQSYPEINFSCNMEQLQDLVGKLKDA 185
Cdd:cd04752 126 VNEPLVQLRLKVRNADTGEITPHPFSVSADKFRVLLAELKQA 167
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 91-194 4.67e-07

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 47.69  E-value: 4.67e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22296603  91 KFDRERIELFCTEYQNNKNSLETLLGSIGRSLPHITDVSWRLEYQIKTNQLHKMYRPGYLVTLNVENNdsqsypeiNFSC 170
Cdd:cd04750  65 GFSDDLNEILLQLYESNRKEIRNILKELSPDLPHYHNLEWRLDVQIASRSLRSQVKPVITMKLHLEDE--------NKKI 136

                        90       100
                ....*....|....*....|....
gi 22296603 171 NMEQLQDLVGKLKDASKSLERATQ 194
Cdd:cd04750 137 ETHLLQTDPANLVHLTQTLEQALQ 160
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 104-184 1.94e-03

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 36.39  E-value: 1.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22296603 104 YQNNKNSLETLLGSIGR-----------SLPHITDVSWRLEYQIKTNQLHKMYRPGYLVTLNVENNDSQSY--PEINfSC 170
Cdd:cd04757   2 HSNLKNLLTKIILENRDkwrseasenqiSLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPSLCGllPPLS-TL 80

                        90
                ....*....|....
gi 22296603 171 NMEQLQDLVGKLKD 184
Cdd:cd04757  81 TMELSKETLDTMLD 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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