F-box only protein 32 isoform 2 [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| F-box_SF super family | cl45894 | F-box domain superfamily; This short domain is commonly found at the N-terminus of various ... |
78-125 | 3.47e-26 | ||
F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures. The actual alignment was detected with superfamily member cd22103: Pssm-ID: 459239 Cd Length: 48 Bit Score: 95.31 E-value: 3.47e-26
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| Elongin_A super family | cl06096 | RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a ... |
120-157 | 2.86e-03 | ||
RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin. The actual alignment was detected with superfamily member pfam06881: Pssm-ID: 462026 Cd Length: 105 Bit Score: 36.04 E-value: 2.86e-03
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| Name | Accession | Description | Interval | E-value | ||
| F-box_FBXO32 | cd22103 | F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called ... |
78-125 | 3.47e-26 | ||
F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called FBX32, atrogin-1, or muscle atrophy F-box protein (MAFbx), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during skeletal muscle atrophy. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438875 Cd Length: 48 Bit Score: 95.31 E-value: 3.47e-26
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| Elongin_A | pfam06881 | RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a ... |
120-157 | 2.86e-03 | ||
RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin. Pssm-ID: 462026 Cd Length: 105 Bit Score: 36.04 E-value: 2.86e-03
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| Name | Accession | Description | Interval | E-value | ||
| F-box_FBXO32 | cd22103 | F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called ... |
78-125 | 3.47e-26 | ||
F-box domain found in F-box only protein 32 (FBXO32) and similar proteins; FBXO32, also called FBX32, atrogin-1, or muscle atrophy F-box protein (MAFbx), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during skeletal muscle atrophy. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438875 Cd Length: 48 Bit Score: 95.31 E-value: 3.47e-26
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| F-box_FBXO25 | cd22099 | F-box domain found in F-box only protein 25 (FBXO25) and similar proteins; FBXO25, also called ... |
79-123 | 2.46e-15 | ||
F-box domain found in F-box only protein 25 (FBXO25) and similar proteins; FBXO25, also called FBX25, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It functions as a negative regulator of MAPK signaling though the reduction of ERK1/2 activation. It controls Tbx5 and Nkx2-5 transcriptional activity to regulate cardiomyocyte development. FBXO25 also plays a crucial role in tumorigenesis. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438871 Cd Length: 45 Bit Score: 67.19 E-value: 2.46e-15
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| F-box_FBXO7 | cd22087 | F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called ... |
83-125 | 5.01e-04 | ||
F-box domain found in F-box only protein 7 (FBXO7) and similar proteins; FBXO7, also called FBX7, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It recognizes BIRC2 and DLGAP5. FBXO7 plays a role downstream of PINK1 in the clearance of damaged mitochondria via selective autophagy (mitophagy) by targeting PRKN to dysfunctional depolarized mitochondria. It promotes MFN1 ubiquitination. FBXO7 acts as a cell cycle regulator by enhancing cyclin D/cyclin-dependent kinase 6 (Cdk6) complex formation and stabilizing levels of p27, a cyclin-dependent kinase inhibitor. Mutations in the FBXO7 (PARK15) gene have been implicated in a juvenile form of parkinsonism called parkinsonian pyramidal syndrome (PPS), characterized by Parkinsonian symptoms and pyramidal tract signs. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438859 Cd Length: 45 Bit Score: 36.51 E-value: 5.01e-04
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| F-box_FBXO4 | cd22085 | F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called ... |
79-125 | 2.78e-03 | ||
F-box domain found in F-box only protein 4 (FBXO4) and similar proteins; FBXO4, also called FBX4, is a specific substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that catalyzes the ubiquitination and subsequent degradation of cyclin D1 and Trx1. It recognizes TERF1 and promotes its ubiquitination together with UBE2D1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438857 Cd Length: 50 Bit Score: 34.69 E-value: 2.78e-03
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| Elongin_A | pfam06881 | RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a ... |
120-157 | 2.86e-03 | ||
RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin. Pssm-ID: 462026 Cd Length: 105 Bit Score: 36.04 E-value: 2.86e-03
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