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Conserved domains on  [gi|45593142|ref|NP_689606|]
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kelch-like protein 40 [Homo sapiens]

Protein Classification

kelch-like protein( domain architecture ID 13034802)

kelch-like protein similar to Homo sapiens kelch-like protein 40 (KLHL40), Mus musculus influenza virus NS1A-binding protein (NS1-BP), and Arabidopsis thaliana F-box/kelch-repeat protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-137 4.10e-82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 254.37  E-value: 4.10e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   6 EQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFL--AEPERAGELHLEEVSPDVVA 83
Cdd:cd18340   1 DQVEELRLYQQTLLQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLsdLEESKKREIVLEDVDPDVMG 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 45593142  84 QVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVF 137
Cdd:cd18340  81 KILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAIF 134
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 128-230 7.16e-54

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18516:

Pssm-ID: 475122 [Multi-domain]  Cd Length: 99  Bit Score: 178.80  E-value: 7.16e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 128 LCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGsgda 207
Cdd:cd18516   1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVG---- 76

                        90       100
                ....*....|....*....|...
gi 45593142 208 EAQAERQRALPTVFESVRCRLLP 230
Cdd:cd18516  77 KDQEERTKALPVLLESIRFRLMP 99
PHA03098 super family cl33709
kelch-like protein; Provisional
 47-551 8.03e-47

kelch-like protein; Provisional


The actual alignment was detected with superfamily member PHA03098:

Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 173.03  E-value: 8.03e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   47 HRLVLAACSPYFRARFlaeperAGELHLEEVS----PDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVS 122
Cdd:PHA03098  26 HKIILSSSSEYFKKMF------KNNFKENEINlnidYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCIN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  123 FLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWA 202
Cdd:PHA03098 100 YIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  203 GSgdaeAQAERQRALPTVFESVRCRLLPRAFLeSRVERHPLVRAQPELLRKVQMVK---DAHEGRITTLRKKKKGKDGAG 279
Cdd:PHA03098 180 TS----KKNNKYKDICLILKVLRITFLSEEGI-KKLKRWKLRIKKKKIVFNKRCIKiiySKKYNLNKILPRSSTFGSIIY 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  280 AKEADKGTSKAKAEEDEEAERIlPGILNDTLRFGM---FLQDLIFMI--------SEEGAVAYDPAANECY-CASLSnqV 347
Cdd:PHA03098 255 IHITMSIFTYNYITNYSPLSEI-NTIIDIHYVYCFgsvVLNNVIYFIggmnknnlSVNSVVSYDTKTKSWNkVPELI--Y 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  348 PKNHVSLVTKENQVFVAGGLFYNEdnkedPMSAyFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGreIKDGER 427
Cdd:PHA03098 332 PRKNPGVTVFNNRIYVIGGIYNSI-----SLNT-VESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG--ISKNDE 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  428 CLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKG--SDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGA 505
Cdd:PHA03098 404 LLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASL 483

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 45593142  506 TVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLS 551
Cdd:PHA03098 484 CIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFPKVIGSLE 529
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 547-594 1.30e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


:

Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 1.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 45593142   547 RSSLSLVSLVGTLYAIGGFAtletesgelVPTELNDIWRYNEEEKKWE 594
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFD---------GNQSLNSVEVYDPETNTWS 40
 
Name Accession Description Interval E-value
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-137 4.10e-82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 254.37  E-value: 4.10e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   6 EQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFL--AEPERAGELHLEEVSPDVVA 83
Cdd:cd18340   1 DQVEELRLYQQTLLQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLsdLEESKKREIVLEDVDPDVMG 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 45593142  84 QVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVF 137
Cdd:cd18340  81 KILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAIF 134
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 128-230 7.16e-54

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 178.80  E-value: 7.16e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 128 LCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGsgda 207
Cdd:cd18516   1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVG---- 76

                        90       100
                ....*....|....*....|...
gi 45593142 208 EAQAERQRALPTVFESVRCRLLP 230
Cdd:cd18516  77 KDQEERTKALPVLLESIRFRLMP 99
PHA03098 PHA03098
kelch-like protein; Provisional
 47-551 8.03e-47

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 173.03  E-value: 8.03e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   47 HRLVLAACSPYFRARFlaeperAGELHLEEVS----PDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVS 122
Cdd:PHA03098  26 HKIILSSSSEYFKKMF------KNNFKENEINlnidYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCIN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  123 FLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWA 202
Cdd:PHA03098 100 YIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  203 GSgdaeAQAERQRALPTVFESVRCRLLPRAFLeSRVERHPLVRAQPELLRKVQMVK---DAHEGRITTLRKKKKGKDGAG 279
Cdd:PHA03098 180 TS----KKNNKYKDICLILKVLRITFLSEEGI-KKLKRWKLRIKKKKIVFNKRCIKiiySKKYNLNKILPRSSTFGSIIY 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  280 AKEADKGTSKAKAEEDEEAERIlPGILNDTLRFGM---FLQDLIFMI--------SEEGAVAYDPAANECY-CASLSnqV 347
Cdd:PHA03098 255 IHITMSIFTYNYITNYSPLSEI-NTIIDIHYVYCFgsvVLNNVIYFIggmnknnlSVNSVVSYDTKTKSWNkVPELI--Y 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  348 PKNHVSLVTKENQVFVAGGLFYNEdnkedPMSAyFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGreIKDGER 427
Cdd:PHA03098 332 PRKNPGVTVFNNRIYVIGGIYNSI-----SLNT-VESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG--ISKNDE 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  428 CLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKG--SDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGA 505
Cdd:PHA03098 404 LLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASL 483

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 45593142  506 TVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLS 551
Cdd:PHA03098 484 CIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFPKVIGSLE 529
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 23-128 8.45e-30

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 113.12  E-value: 8.45e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142    23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG--ELHLEEVSPDVVAQVLHYLYTSEIaLDEAS 100
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSvsEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 45593142   101 VQDLFAAAHRFQIPSIFTICVSFLQKRL 128
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
390-594 1.75e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 115.25  E-value: 1.75e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 390 SEWLGMPPLPSPRCLFGLGEALNSIYVVGGReikDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTV-LSHMDLVYVIG 468
Cdd:COG3055   1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGL---SGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAaVAQDGKLYVFG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 469 G---KGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQ 545
Cdd:COG3055  78 GftgANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPT 157

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45593142 546 ERSSLSLVSLV-GTLYAIGGF----ATLETESGELVPTE----------------------LNDIWRYNEEEKKWE 594
Cdd:COG3055 158 PRDHLAAAVLPdGKILVIGGRngsgFSNTWTTLAPLPTAraghaaavlggkilvfggesgfSDEVEAYDPATNTWT 233
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 133-237 1.82e-27

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 106.27  E-value: 1.82e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142    133 CLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGsgdaEAQAE 212
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVK----HDPEK 76

                           90       100
                   ....*....|....*....|....*
gi 45593142    213 RQRALPTVFESVRCRLLPRAFLESR 237
Cdd:smart00875  77 RREHLPELLEHVRLPLLSPDYLLEV 101
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 133-239 2.04e-27

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 106.48  E-value: 2.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   133 CLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgsgdAEAQAE 212
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWV----KHDVER 76

                          90       100
                  ....*....|....*....|....*..
gi 45593142   213 RQRALPTVFESVRCRLLPRAFLESRVE 239
Cdd:pfam07707  77 RKKHLPELLSAVRLPLLSPQYLLNLVE 103
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 34-128 9.22e-24

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 95.84  E-value: 9.22e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142     34 DCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG--ELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRF 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDksEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 45593142    112 QIPSIFTICVSFLQKRL 128
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
Kelch smart00612
Kelch domain;
463-510 9.23e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 51.41  E-value: 9.23e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 45593142    463 LVYVIGGkGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDG 510
Cdd:smart00612   1 KIYVVGG-FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_6 pfam13964
Kelch motif;
454-500 1.91e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.02  E-value: 1.91e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 45593142   454 GHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTAR 500
Cdd:pfam13964   4 FHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 547-594 1.30e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 1.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 45593142   547 RSSLSLVSLVGTLYAIGGFAtletesgelVPTELNDIWRYNEEEKKWE 594
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFD---------GNQSLNSVEVYDPETNTWS 40
 
Name Accession Description Interval E-value
BTB_POZ_KLHL40_KBTBD5 cd18340
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-137 4.10e-82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5 (KBTBD5) or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy. KLHL40 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349649 [Multi-domain]  Cd Length: 134  Bit Score: 254.37  E-value: 4.10e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   6 EQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFL--AEPERAGELHLEEVSPDVVA 83
Cdd:cd18340   1 DQVEELRLYQQTLLQDGLKDLLDHNKFVDCVLKIKEKEFPCHRLVLAACSPYFRAMFLsdLEESKKREIVLEDVDPDVMG 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 45593142  84 QVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVF 137
Cdd:cd18340  81 KILHYIYTSEIEITEQNVQDIFAAANMFQIPSIFTVCVSFLQKRLCLSNCLAIF 134
BTB_POZ_KLHL40-like cd18269
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-136 1.69e-78

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL40 and KLHL41; This family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349578 [Multi-domain]  Cd Length: 133  Bit Score: 244.62  E-value: 1.69e-78
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   6 EQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLA--EPERAGELHLEEVSPDVVA 83
Cdd:cd18269   1 EQKEELRLYQQTLLQDGLKDLLDENKFVDCVLKIGDKEFPCHRLVLAACSPYFRAMFLSdlEESKKKEVVLEDVDPDVMG 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 45593142  84 QVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18269  81 MILKYLYTSEIDLNDQNVQDIFALASRFQIPSIFTVCVSYLQKRLSLSNCLAI 133
BTB_POZ_KLHL41_KBTBD10 cd18341
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 6-136 1.22e-55

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 41 (KLHL41); KLHL41 is also called Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10 (KBTBD10), Kelch-related protein 1 (Krp1), or sarcosine. It is a novel kelch-related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349650 [Multi-domain]  Cd Length: 133  Bit Score: 184.66  E-value: 1.22e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   6 EQAEEQRLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPDVVA 83
Cdd:cd18341   1 EIKEELRLYQSTLLQDGLKELLDENKFVDCTLKAGDKSLPCHRLILAACSPYFREYFLSEesEEKKKEVVLDNVDPNIMD 80

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 45593142  84 QVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18341  81 MILKYLYSAEIDLNDGNVQDIFALASRFQIPSVFTVCVTYLQKRLSPANCLAI 133
BACK_KLHL40_KBTBD5 cd18516
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also ...
 128-230 7.16e-54

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 40 (KLHL40); KLHL40, also called Kelch repeat and BTB domain-containing protein 5, or sarcosynapsin, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. Mutations in KLHL40 may cause severe autosomal-recessive nemaline myopathy.


Pssm-ID: 350591 [Multi-domain]  Cd Length: 99  Bit Score: 178.80  E-value: 7.16e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 128 LCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGsgda 207
Cdd:cd18516   1 LCLSNCLAIFRLGLLLDCPRLAVAARDFICDRFQLIARDEDFLQLSPDELIAIISSDSLNVEKEEDVFEAVMKWVG---- 76

                        90       100
                ....*....|....*....|...
gi 45593142 208 EAQAERQRALPTVFESVRCRLLP 230
Cdd:cd18516  77 KDQEERTKALPVLLESIRFRLMP 99
BACK_KLHL40_like cd18477
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The ...
 128-230 5.45e-53

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL40 and KLHL41; The family includes Kelch-like proteins, KLHL40 and KLHL41. KLHL40 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a key regulator of skeletal muscle development. KLHL41 is a novel kelch related protein that is involved in pseudopod elongation in transformed cells.


Pssm-ID: 350552 [Multi-domain]  Cd Length: 99  Bit Score: 176.57  E-value: 5.45e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 128 LCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGsgda 207
Cdd:cd18477   1 LCLGNCLAIFRLGLLLDCPRLAVSARDFICAHFTLVAKDEDFLGLSADELIAIISSDGLNVEKEEAVFEAVMKWVR---- 76

                        90       100
                ....*....|....*....|...
gi 45593142 208 EAQAERQRALPTVFESVRCRLLP 230
Cdd:cd18477  77 EAKENRQKALPTVFESIRFRLLP 99
PHA03098 PHA03098
kelch-like protein; Provisional
 47-551 8.03e-47

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 173.03  E-value: 8.03e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   47 HRLVLAACSPYFRARFlaeperAGELHLEEVS----PDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVS 122
Cdd:PHA03098  26 HKIILSSSSEYFKKMF------KNNFKENEINlnidYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFLINLCIN 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  123 FLQKRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWA 202
Cdd:PHA03098 100 YIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELIYNDPDFIYLSKNELIKILSDDKLNVSSEDVVLEIIIKWL 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  203 GSgdaeAQAERQRALPTVFESVRCRLLPRAFLeSRVERHPLVRAQPELLRKVQMVK---DAHEGRITTLRKKKKGKDGAG 279
Cdd:PHA03098 180 TS----KKNNKYKDICLILKVLRITFLSEEGI-KKLKRWKLRIKKKKIVFNKRCIKiiySKKYNLNKILPRSSTFGSIIY 254

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  280 AKEADKGTSKAKAEEDEEAERIlPGILNDTLRFGM---FLQDLIFMI--------SEEGAVAYDPAANECY-CASLSnqV 347
Cdd:PHA03098 255 IHITMSIFTYNYITNYSPLSEI-NTIIDIHYVYCFgsvVLNNVIYFIggmnknnlSVNSVVSYDTKTKSWNkVPELI--Y 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  348 PKNHVSLVTKENQVFVAGGLFYNEdnkedPMSAyFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVVGGreIKDGER 427
Cdd:PHA03098 332 PRKNPGVTVFNNRIYVIGGIYNSI-----SLNT-VESWKPGESKWREEPPLIFPRYNPCVVNVNNLIYVIGG--ISKNDE 403

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  428 CLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKG--SDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGA 505
Cdd:PHA03098 404 LLKTVECFSLNTNKWSKGSPLPISHYGGCAIYHDGKIYVIGGISyiDNIKVYNIVESYNPVTNKWTELSSLNFPRINASL 483

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 45593142  506 TVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQERSSLS 551
Cdd:PHA03098 484 CIFNNKIYVVGGDKYEYYINEIEVYDDKTNTWTLFCKFPKVIGSLE 529
BACK_KLHL41_KBTBD10 cd18517
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also ...
 128-230 7.55e-37

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 41 (KLHL41); KLHL41, also called Kel-like protein 23, or Kelch repeat and BTB domain-containing protein 10, or Kelch-related protein 1 (Krp1), or sarcosine, is a novel kelch related protein that is involved in pseudopod elongation in transformed cells. It is also involved in skeletal muscle development and differentiation. It regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils.


Pssm-ID: 350592 [Multi-domain]  Cd Length: 99  Bit Score: 132.59  E-value: 7.55e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 128 LCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGda 207
Cdd:cd18517   1 LSVGNCLAIFRLGLLLDCPRLAVSARDFVSDRFEQISKEEDFLQLAPHELIAIISSDSLNVEKEELVFEAVMKWVRTD-- 78

                        90       100
                ....*....|....*....|...
gi 45593142 208 eaQAERQRALPTVFESVRCRLLP 230
Cdd:cd18517  79 --KENRVKSLGEIFDCIRFRLMP 99
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 23-128 8.45e-30

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 113.12  E-value: 8.45e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142    23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG--ELHLEEVSPDVVAQVLHYLYTSEIaLDEAS 100
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSvsEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*...
gi 45593142   101 VQDLFAAAHRFQIPSIFTICVSFLQKRL 128
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIKSL 107
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
390-594 1.75e-28

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 115.25  E-value: 1.75e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 390 SEWLGMPPLPSPRCLFGLGEALNSIYVVGGReikDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTV-LSHMDLVYVIG 468
Cdd:COG3055   1 ATWSSLPDLPTPRSEAAAALLDGKVYVAGGL---SGGSASNSFEVYDPATNTWSELAPLPGPPRHHAAaVAQDGKLYVFG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 469 G---KGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAFPQ 545
Cdd:COG3055  78 GftgANPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPT 157

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 45593142 546 ERSSLSLVSLV-GTLYAIGGF----ATLETESGELVPTE----------------------LNDIWRYNEEEKKWE 594
Cdd:COG3055 158 PRDHLAAAVLPdGKILVIGGRngsgFSNTWTTLAPLPTAraghaaavlggkilvfggesgfSDEVEAYDPATNTWT 233
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-111 3.74e-28

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 107.64  E-value: 3.74e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  32 FLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAH 109
Cdd:cd18186   1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGmkESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAAD 80


                ..
gi 45593142 110 RF 111
Cdd:cd18186  81 KL 82
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 133-237 1.82e-27

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 106.27  E-value: 1.82e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142    133 CLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGsgdaEAQAE 212
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLSSDDLNVSSEEEVFEAVLRWVK----HDPEK 76

                           90       100
                   ....*....|....*....|....*
gi 45593142    213 RQRALPTVFESVRCRLLPRAFLESR 237
Cdd:smart00875  77 RREHLPELLEHVRLPLLSPDYLLEV 101
BACK pfam07707
BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The ...
 133-239 2.04e-27

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).


Pssm-ID: 462237 [Multi-domain]  Cd Length: 103  Bit Score: 106.48  E-value: 2.04e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   133 CLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgsgdAEAQAE 212
Cdd:pfam07707   1 CLGIYRFADAYGCTELAEAALRFILQNFLEVAKSEEFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWV----KHDVER 76

                          90       100
                  ....*....|....*....|....*..
gi 45593142   213 RQRALPTVFESVRCRLLPRAFLESRVE 239
Cdd:pfam07707  77 RKKHLPELLSAVRLPLLSPQYLLNLVE 103
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
351-578 8.25e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 110.25  E-value: 8.25e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 351 HVSLVTKENQVFVAGGLFYNEDnkedpmSAYFLQFDHLDSEWLGMPPLPSPR----CLFGLGealNSIYVVGGR-EIKDG 425
Cdd:COG3055  15 EAAAALLDGKVYVAGGLSGGSA------SNSFEVYDPATNTWSELAPLPGPPrhhaAAVAQD---GKLYVFGGFtGANPS 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 426 ERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGkGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGA 505
Cdd:COG3055  86 STPLNDVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVGG-WDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAA 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 506 TVH-DGRIIVAAGVTDTGLT-----------------------------------SSAEVYSITDNKWAPFEAFPQERSS 549
Cdd:COG3055 165 AVLpDGKILVIGGRNGSGFSntwttlaplptaraghaaavlggkilvfggesgfsDEVEAYDPATNTWTALGELPTPRHG 244

                       250       260
                ....*....|....*....|....*....
gi 45593142 550 LSLVSLVGTLYAIGGfatlETESGELVPT 578
Cdd:COG3055 245 HAAVLTDGKVYVIGG----ETKPGVRTPL 269
BTB_POZ_KLHL10 cd18240
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-133 4.26e-26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349549 [Multi-domain]  Cd Length: 120  Bit Score: 103.18  E-value: 4.26e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFA 106
Cdd:cd18240  15 GKLCDVVIRVNGVEFPAHRNILCACSPYFRALFtngWNETEKK-VYKIPGVSPEMMELIIEYAYTRTVPITAENVEELLP 93

                        90       100
                ....*....|....*....|....*..
gi 45593142 107 AAHRFQIPSIFTICVSFLQKRLCLSNC 133
Cdd:cd18240  94 AADQFNIMGIVKACCDFLEDQLCPENC 120
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-135 2.43e-25

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 101.21  E-value: 2.43e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLE--EVSPDVVAQVLHYLYTSEIALDEAS 100
Cdd:cd18238   6 LHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITikDIDEEAVELLVDFAYTGKLTLTVDN 85

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45593142 101 VQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLA 135
Cdd:cd18238  86 VQSLLYAASLLQVEEVAKACCEFMKDHLHPSNCLG 120
BACK_KLHL2_like cd18445
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This ...
 131-245 4.29e-24

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL2 and KLHL3; This subfamily includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. Both KLHL2 and KLHL3 function as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins.


Pssm-ID: 350520 [Multi-domain]  Cd Length: 114  Bit Score: 97.30  E-value: 4.29e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSgDAEAq 210
Cdd:cd18445   4 SNCLGIRAFADLHSCTDLLKYAQTYTEQHFSEVVKGEEFLLLSKEQVCELISSDDLTVPSEEKVFEAVMSWVNH-DPEN- 81

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45593142 211 aeRQRALPTVFESVRCRLLPRAFLESRVERHPLVR 245
Cdd:cd18445  82 --RKEHLAELLEHVRLPLLSPEYLVQRVEEEELIK 114
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 34-128 9.22e-24

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 95.84  E-value: 9.22e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142     34 DCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG--ELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRF 111
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDksEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 45593142    112 QIPSIFTICVSFLQKRL 128
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB_POZ_KBTBD8 cd18274
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-136 2.29e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralog TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349583 [Multi-domain]  Cd Length: 129  Bit Score: 95.82  E-value: 2.29e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  17 TLLQDgLKDMLDHGKFLDCVVRAGE-REFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLYTS 92
Cdd:cd18274   8 SILQQ-LKAMYDEGQLTDIVVEVDHgKTFSCHRNVLAAISPYFRSMFtsgLTESTQK-EVRIVGVEAESMHLVLDYAYTS 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 45593142  93 EIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18274  86 RVTLTEANVQALFTAASIFQIPSLQDQCAQFMISRLDPQNSIGV 129
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-133 7.64e-23

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 94.06  E-value: 7.64e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  19 LQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPDVVAQVLHYLYTSEIAL 96
Cdd:cd18250   8 LLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAGElrESRADRVVLHGVSAEILGLLLDFSYTGRVTV 87

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 45593142  97 DEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNC 133
Cdd:cd18250  88 TQDNVEALLRAADLFQFPSVKEACCAYLQQRLDVSNC 124
BTB_POZ_KBTBD6_7 cd18273
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-138 3.82e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing proteins KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling. They both contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349582 [Multi-domain]  Cd Length: 142  Bit Score: 92.58  E-value: 3.82e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  19 LQDGLKDMLDHGKFLDCVVR--------AGEREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLH 87
Cdd:cd18273  13 LLAQLKSFYDARLLTDVTIEvngpgsgpGSGRLFPCNRNVLAAASPYFKSMFtggLYESKQE-TVTIHDVDSESMALIID 91

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|.
gi 45593142  88 YLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVFR 138
Cdd:cd18273  92 YCYTGRVTLSEANVQRLYAAANMLQLEYVREACASFLARRLDLSNCVGILK 142
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-134 6.29e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 91.78  E-value: 6.29e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPDVVAQVLHYLYTSEIALDEAS 100
Cdd:cd18237  12 MNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTSNmtESKSSEVELKDAEPDIIELLVEFAYTARISVNSNN 91

                        90       100       110
                ....*....|....*....|....*....|....
gi 45593142 101 VQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCL 134
Cdd:cd18237  92 VQSLLDAANQYQIEPVKKMCVDFLKEQLDASNCL 125
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-135 6.63e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 91.76  E-value: 6.63e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE-PE-RAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAA 107
Cdd:cd18265  21 GTFTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHlKEsRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEA 100

                        90       100
                ....*....|....*....|....*...
gi 45593142 108 AHRFQIPSIFTICVSFLQKRLCLSNCLA 135
Cdd:cd18265 101 SDLLQVSKLREACVRFLEGQLHPCNCLG 128
BTB_POZ_KLHL24_KRIP6 cd18253
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-133 6.65e-22

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349562 [Multi-domain]  Cd Length: 121  Bit Score: 91.44  E-value: 6.65e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  22 GLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLE--EVSPDVVAQVLHYLYTSEIALDEA 99
Cdd:cd18253   8 VFNEFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFCNDHRESREMLVEinGILAEAMDCFLQYVYTGKVKITTE 87

                        90       100       110
                ....*....|....*....|....*....|....
gi 45593142 100 SVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNC 133
Cdd:cd18253  88 NVQYLFETSSLFQISPLRDACAKFLEEQLDPCNC 121
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-134 1.09e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 91.43  E-value: 1.09e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  16 QTLLqDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLYTS 92
Cdd:cd18259  17 QSIL-DGLQTLRSNPKLSDVTLLVGGREFPCHRSVLALCSHYFNAMFtgdFVESISA-RVEIKDVDPAVMESLIDFAYTG 94

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45593142  93 EIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCL 134
Cdd:cd18259  95 KLTINQGNVEALIRTSNRLQFPTVRKVCSRYLQQQIDATNCL 136
BTB_POZ_KLHL38 cd18268
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-136 1.65e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 38 (KLHL38); KLHL38 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The KLHL38 gene is significantly up-regulated during diapause, a temporary arrest of development during early ontogeny. It may also function in preadipocyte differentiation in the chicken. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349577 [Multi-domain]  Cd Length: 129  Bit Score: 90.62  E-value: 1.65e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  32 FLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAA 108
Cdd:cd18268  23 LTDVILCTGDKEIPCHRNVLASSSPYFRAMFcnnFRESSQA-KVDLKGIDSDVLDQIVDYVYTGEILITRDNVLPLMEAA 101

                        90       100
                ....*....|....*....|....*...
gi 45593142 109 HRFQIPSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18268 102 SMLQYPKLFEACSLYLQDQLTPENCLSM 129
BTB_POZ_KLHL27_IPP cd18256
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-134 7.86e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349565 [Multi-domain]  Cd Length: 125  Bit Score: 88.23  E-value: 7.86e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLQdGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLY 90
Cdd:cd18256   3 HASLILA-QLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFaggMSESSKD-VVQIHGVEPDIFHILLDFIY 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 45593142  91 TSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCL 134
Cdd:cd18256  81 TGVVEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHPSNCI 124
BTB_POZ_KLHL1-like cd18234
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-134 8.01e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349543 [Multi-domain]  Cd Length: 105  Bit Score: 87.81  E-value: 8.01e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  34 DCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG--ELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRF 111
Cdd:cd18234   3 DVILIAGDRRIPAHRLVLSAVSDYFAAMFTNDVREATeeEIKLKDVDPDALWTLVQYCYTGRLELKEDNVESLLATACLL 82

                        90       100
                ....*....|....*....|...
gi 45593142 112 QIPSIFTICVSFLQKRLCLSNCL 134
Cdd:cd18234  83 QLSEVVEACCGFLMKQLHPSNCL 105
BTB_POZ_KLHL37_ENC1 cd18267
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-136 6.56e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349576 [Multi-domain]  Cd Length: 147  Bit Score: 86.58  E-value: 6.56e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  32 FLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEpERAGELHLEE-VSPDVVAQVLHYLYTSEIALDEASVQDLFAA 107
Cdd:cd18267  40 FTDVLLHAGNRSFPCHRAVLAACSRYFEAMFsggLKE-SQDSEVNFHDsIHPEVLELLLDYAYSSRVIINEENAESLLEA 118

                        90       100
                ....*....|....*....|....*....
gi 45593142 108 AHRFQIPSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18267 119 GDMLEFQDIRDACAEFLEKNLHPTNCLGM 147
BTB_POZ_KLHL4 cd18336
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-136 6.65e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349645 [Multi-domain]  Cd Length: 126  Bit Score: 85.87  E-value: 6.65e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  15 QQTLLQdgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG--ELHLEEVSPDVVAQVLHYLYTS 92
Cdd:cd18336   4 EQTFRK--MENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTNDVREAKqeEIKMEGVDPDALKALVHYAYTG 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 45593142  93 EIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18336  82 VLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHPSNCLGI 125
BTB_POZ_KLHL2-like cd18235
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-128 7.62e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349544 [Multi-domain]  Cd Length: 121  Bit Score: 85.56  E-value: 7.62e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  25 DMLDHGKFL-DCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASV 101
Cdd:cd18235  13 NELRKQNLLcDVILVADGVEIPAHRVVLASCSPYFHAMFTGDlsESRANRVTLQDVDGKALLLLIDYVYTAEIQVTEENV 92

                        90       100
                ....*....|....*....|....*..
gi 45593142 102 QDLFAAAHRFQIPSIFTICVSFLQKRL 128
Cdd:cd18235  93 QVLLPAANLLQLTDVRDACCDFLQSQL 119
BTB_POZ_KBTBD12 cd18276
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-136 1.69e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also called Kelch domain-containing protein 6 (KLHDC6), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349585 [Multi-domain]  Cd Length: 127  Bit Score: 84.86  E-value: 1.69e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  19 LQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLYTSEIA 95
Cdd:cd18276   8 LLDQLNRMKELAELTDVVLVAEGEKFPCHRLVLAAFSPYFKAMFtcgLMECSQR-EVVLHDITAESVSIILNYMYSSDLH 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45593142  96 LDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18276  87 LTNSNVQGVATAAFFLQMEDIFSVCQKYMMDHMDASNCLGI 127
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-128 3.84e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 83.36  E-value: 3.84e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLQdGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLY 90
Cdd:cd18257   1 HSEQLLQ-GLNLLRQHHELCDVVLRVGDVKIHAHKVVLASCSPYFKAMFtgnLSEKENS-EVEFQCIDETALQAIVEYAY 78

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 45593142  91 TSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRL 128
Cdd:cd18257  79 TGTVFISQATVESLLPAANLLQIKLVLKECCDFLESQL 116
BTB_POZ_KLHL26 cd18255
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-133 4.06e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349564 [Multi-domain]  Cd Length: 121  Bit Score: 83.21  E-value: 4.06e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  17 TLLQdGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLYTSE 93
Cdd:cd18255   4 TLLQ-GLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFtggMRESSQD-EIELKGVSAKGLKHILDFAYTSE 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45593142  94 IALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNC 133
Cdd:cd18255  82 LTLDLDCIQDVLGAAVHLQMLPVVELCEEFLKSAMSVENC 121
BTB_POZ_NS1BP cd18306
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-136 4.06e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349615 [Multi-domain]  Cd Length: 124  Bit Score: 83.46  E-value: 4.06e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELH--LEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAA 107
Cdd:cd18306  16 RQFCDVILQVGGHEIPAHRAVLACASPYLFELFSSDSDGESILTvkLDGLDPDAVEVLVNYAYTSRLEVPADLVKSVYSA 95

                        90       100
                ....*....|....*....|....*....
gi 45593142 108 AHRFQIPSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18306  96 AKKLKMDRVKKACGDFLLEKLTPQNCIGI 124
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
330-531 5.36e-19

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 87.52  E-value: 5.36e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 330 AYDPAANECYCASLSNQVPKNHVSLVtKENQVFVAGGLFYNEDNKEdpmsayFLQFDHLDSEWLGMPPLPSPRCLFGLGE 409
Cdd:COG3055  94 VYDPATNTWTKLAPMPTPRGGATALL-LDGKIYVVGGWDDGGNVAW------VEVYDPATGTWTQLAPLPTPRDHLAAAV 166

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 410 ALNS-IYVVGGREIKDGercldsvmcydrlSFKWGESDPLPYVVYGHTVLSHMDLVYVIGGKGSDrkcLNKMCVYDPKKF 488
Cdd:COG3055 167 LPDGkILVIGGRNGSGF-------------SNTWTTLAPLPTARAGHAAAVLGGKILVFGGESGF---SDEVEAYDPATN 230

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 45593142 489 EWKELAPMQTARSLFGATVHDGRIIVAAGVTDTG----LTSSAEVYS 531
Cdd:COG3055 231 TWTALGELPTPRHGHAAVLTDGKVYVIGGETKPGvrtpLVTSAEVYD 277
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-127 6.10e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 82.71  E-value: 6.10e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEpERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFA 106
Cdd:cd18247  17 GKLCDVTLKVGDQKFSAHRIVLAATIPYFHAMFthdMVE-SKQDEITMQGIEPSALEALINFAYSGRIAIDTSNVQSLLV 95

                        90       100
                ....*....|....*....|.
gi 45593142 107 AAHRFQIPSIFTICVSFLQKR 127
Cdd:cd18247  96 GASFLQLQSVKDACCEFLKER 116
BTB_POZ_KLHL12_C3IP1_DKIR cd18242
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-133 8.02e-19

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349551 [Multi-domain]  Cd Length: 124  Bit Score: 82.49  E-value: 8.02e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG--ELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAA 107
Cdd:cd18242  19 NTLCDVTLRVEGKEFPAHRIVLAACSDYFCAMFTSEMSEKGksEVELQGLTASTMEILLDFVYTETVHVTVENVQELLPA 98

                        90       100
                ....*....|....*....|....*.
gi 45593142 108 AHRFQIPSIFTICVSFLQKRLCLSNC 133
Cdd:cd18242  99 ACLLQLKGVKQACCEFLESQLDPSNC 124
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-134 1.04e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 82.74  E-value: 1.04e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLQDgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLA--EPERAGELHLEEVSPDVVAQVLHYLYT 91
Cdd:cd18270   9 YAVSLLEQ-LKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRAMFMSglSESKQTHVHLRNVDAATLQIIITYAYT 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45593142  92 SEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCL 134
Cdd:cd18270  88 GNLAINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCV 130
BTB_POZ_KLHL19_KEAP1 cd18248
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 25-128 1.11e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also called cytosolic inhibitor of Nrf2 (INrf2) or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349557 [Multi-domain]  Cd Length: 124  Bit Score: 82.43  E-value: 1.11e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  25 DMLDHGKFL-DCVVRAG----EREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLYTSEIAL 96
Cdd:cd18248  13 NELRLSQQLcDVTLKVKyqdpKEEFMAHKVVLASSSPYFKAMFtsgLRECGME-VVPIEGVHPCVMSRLIEFAYTASISV 91

                        90       100       110
                ....*....|....*....|....*....|..
gi 45593142  97 DEASVQDLFAAAHRFQIPSIFTICVSFLQKRL 128
Cdd:cd18248  92 GEKCVLHVLPGAVMYQMDSVVKACCDFLEQQL 123
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-125 1.65e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 81.23  E-value: 1.65e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  18 LLQdGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG----ELHLEEVSPDVVAQVLHYLYTSE 93
Cdd:cd18245   1 LLR-ALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNPPKDDgstyKIELEGISVEVMEEILDYIYTGQ 79

                        90       100       110
                ....*....|....*....|....*....|..
gi 45593142  94 IALDEASVQDLFAAAHRFQIPSIFTICVSFLQ 125
Cdd:cd18245  80 IKLSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111
BTB_POZ_KLHL25 cd18254
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-134 2.08e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349563 [Multi-domain]  Cd Length: 128  Bit Score: 81.60  E-value: 2.08e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEA 99
Cdd:cd18254  13 LNTLRKQCMFTDVTLWAGNRSFPCHRAVLAACSRYFEAMFsngLRESLDSTVNFHDSLHPEVLELLLDFAYSSRIIINEE 92

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45593142 100 SVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCL 134
Cdd:cd18254  93 NAESLLEAGDMLQFHDVRDAAAEFLEKNLYPSNCL 127
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 31-120 3.59e-18

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 79.70  E-value: 3.59e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  31 KFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELH--LEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAA 108
Cdd:cd18314   5 EFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEvtLEDVEPEIFETVLKYMYTGQVTLSEENVLDLLMLA 84

                        90
                ....*....|..
gi 45593142 109 HRFQIPSIFTIC 120
Cdd:cd18314  85 SKYQVPDLEKLC 96
BTB_POZ_KLHL6 cd18236
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 17-133 9.22e-18

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349545 [Multi-domain]  Cd Length: 129  Bit Score: 79.89  E-value: 9.22e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  17 TLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE--LHLEEVSPDVVAQVLHYLYTSEI 94
Cdd:cd18236   9 LVLQNGLENLRLENSLTDVILCVDSQEFSCHRVVLAAASNYFRAMFCNDLKEKYEekIIIKGVDAETMQILLDYTYTSKV 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 45593142  95 ALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNC 133
Cdd:cd18236  89 LITKQNVQRVLEAASLFQFLRMVDACASFLTEALHPENC 127
BACK_KLHL18 cd18457
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as ...
 132-238 1.11e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A.


Pssm-ID: 350532 [Multi-domain]  Cd Length: 107  Bit Score: 78.89  E-value: 1.11e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 132 NCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgsgdAEAQA 211
Cdd:cd18457   5 NCLGIRQFAETMMCSSLVDAANKYIQQHFIEVSKSEEFLALSKEEVLEILSRDELNVKSEEQVFEAALAWV----KYDRE 80

                        90       100
                ....*....|....*....|....*..
gi 45593142 212 ERQRALPTVFESVRCRLLPRAFLESRV 238
Cdd:cd18457  81 NREEYLPELLSKVRLPLLRPQFLTDRV 107
BTB_POZ_KLHL20_KLEIP cd18249
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-134 1.90e-17

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349558 [Multi-domain]  Cd Length: 128  Bit Score: 79.03  E-value: 1.90e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  29 HGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEpERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLF 105
Cdd:cd18249  20 HRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFtgeLAE-SRQTEVTIRDIDERAMELLIDFAYTSQITVEEGNVQTLL 98

                        90       100
                ....*....|....*....|....*....
gi 45593142 106 AAAHRFQIPSIFTICVSFLQKRLCLSNCL 134
Cdd:cd18249  99 PAACLLQLAEIQEVCCEFLKRQLDPSNCL 127
BACK_KLHL3 cd18513
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as ...
 131-245 1.97e-17

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 3 (KLHL3); KLHL3 serves as a substrate adapter in Cullin3 (Cul3) E3 ubiquitin ligase complexes. It is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation.


Pssm-ID: 350588 [Multi-domain]  Cd Length: 130  Bit Score: 78.96  E-value: 1.97e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSgDAEAQ 210
Cdd:cd18513   4 TNCLGIRAFADVHTCTELLQQANAYAEQHFPEVMLGEEFLSLSLDQVCSLISSDKLTVSSEEKVFEAVISWIKY-DKEAR 82

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45593142 211 AERqraLPTVFESVRCRLLPRAFLESRVERHPLVR 245
Cdd:cd18513  83 LEH---MAKLMEHVRLPLLPRDYLVQTVEEEALIK 114
BACK_KLHL8 cd18448
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a ...
 131-225 1.30e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN.


Pssm-ID: 350523 [Multi-domain]  Cd Length: 97  Bit Score: 75.42  E-value: 1.30e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgsgdAEAQ 210
Cdd:cd18448   5 SNCLGVRTFAEQHNRVDLMKMADKYACDHFNEVVECEEFVSISAQHLEKLISSSDLNVESESQVYEAVMKWV----KHDP 80

                        90
                ....*....|....*
gi 45593142 211 AERQRALPTVFESVR 225
Cdd:cd18448  81 QHRKRHLDDLLSQVR 95
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-134 1.40e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 76.16  E-value: 1.40e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  31 KFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG-----ELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLF 105
Cdd:cd18258  16 EFTDLKIIVEGKEFEVHQNVLASCSLYFKDLIKRSSRDSGggeklELTMSNINADVLELLLEFVYTGSLIIDSANAKTLL 95

                        90       100
                ....*....|....*....|....*....
gi 45593142 106 AAAHRFQIPSIFTICVSFLQKRLCLSNCL 134
Cdd:cd18258  96 EAANKFQFHTFCKVCVSFLEKQLTASNCL 124
BTB_POZ_BTBD18 cd18293
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-120 1.57e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 18 (BTBD18); BTBD18 acts as a specific controller for transcription activation through RNA polymerase II elongation at a subset of genomic PIWI-interacting RNA (piRNA) loci. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349602 [Multi-domain]  Cd Length: 120  Bit Score: 75.98  E-value: 1.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE---LHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFA 106
Cdd:cd18293  13 GVFCDVLLQAEGESVPAHCCVLSACSPYLTERLSSEPPPAGQkvvLELQGLKAHTLLKLVDFLYTSELEVSSEEAQDVLA 92

                        90
                ....*....|....
gi 45593142 107 AAHRFQIPSIFTIC 120
Cdd:cd18293  93 AARRLQISELESLC 106
BACK_KLHL2_Mayven cd18512
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also ...
 131-245 1.62e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation.


Pssm-ID: 350587 [Multi-domain]  Cd Length: 130  Bit Score: 76.22  E-value: 1.62e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSgDAEAq 210
Cdd:cd18512   4 TNCLGIRAFADMHACTELLNQANTYAEQHFSDVVLSEEFLNLGIEQVCSLIASDKLTISSEEKVFEAVIAWVNH-DKEV- 81

                        90       100       110
                ....*....|....*....|....*....|....*
gi 45593142 211 aeRQRALPTVFESVRCRLLPRAFLESRVERHPLVR 245
Cdd:cd18512  82 --RQEHMAHLMEHVRLPLLSREYLVQRVEEETLVK 114
BTB_POZ_KLHL23 cd18252
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-134 1.73e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 23 (KLHL23); KLHL23 overexpression is associated with increased cell proliferation and invasion in gastric cancer. Downregulation of KLHL23 is associated with invasion, metastasis, and poor prognosis of hepatocellular carcinoma and pancreatic cancer. KLHL23 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349561 [Multi-domain]  Cd Length: 127  Bit Score: 76.02  E-value: 1.73e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  21 DGLKDMLDHGKFLDCVVRAGERE-FPCHRLVLAACSPYFRARFLAEPERAGE--LHLEEVSPDVVAQVLHYLYTSEIALD 97
Cdd:cd18252  10 DAFRTFYLDGLFTDITLQCASGQiFHCHKAALAACSSYFKVMFTADMKEKSNnvIKLSGIDHDILEALVNYVYTSQICIT 89

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 45593142  98 EASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCL 134
Cdd:cd18252  90 ERNVQSLLEAADLLQFISVKKACEQFLVRHLDIDNCL 126
BTB_POZ_KLHL3 cd18339
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-128 1.93e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 3 (KLHL3); KLHL3 is a component of an E3 ubiquitin ligase complex that regulates blood pressure by targeting With-No-Lysine (WNK) kinases for degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349648 [Multi-domain]  Cd Length: 121  Bit Score: 75.91  E-value: 1.93e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  34 DCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRF 111
Cdd:cd18339  23 DVTIVAEDVEIEAHRVVLAACSPYFCAMFTGDmsESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLL 102

                        90
                ....*....|....*..
gi 45593142 112 QIPSIFTICVSFLQKRL 128
Cdd:cd18339 103 QLMDVRQNCCDFLQSQL 119
BACK_KLHL10 cd18450
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be ...
 128-201 2.70e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 10 (KLHL10); KLHL10 may be a substrate-specific adapter of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during spermatogenesis.


Pssm-ID: 350525 [Multi-domain]  Cd Length: 80  Bit Score: 73.80  E-value: 2.70e-16
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45593142 128 LCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARD-ADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRW 201
Cdd:cd18450   1 LTPENCIGIRKFARYYFCPELERKAYRYILRNFEEVAKDsEEFLELSCEELEDIIEDDELNVKEEEVVFEAIVKW 75
BACK_KLHL12 cd18452
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also ...
 131-246 3.64e-16

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also termed CUL3-interacting protein 1 (C3IP1), or DKIR, is a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of Wnt signaling pathway and ER-Golgi transport.


Pssm-ID: 350527 [Multi-domain]  Cd Length: 136  Bit Score: 75.51  E-value: 3.64e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgsgdAEAQ 210
Cdd:cd18452   4 SNCLGIRDFAETHNCVDLMQAAEVFSQKHFPEVVQHEEFMLLSQEEVEKLIKSDEIQVDSEEPVFEAVLNWV----KHDK 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45593142 211 AERQRALPTVFESVRCRLLPRAFLESRVERHPLVRA 246
Cdd:cd18452  80 EEREDYLPELLQYVRLPLLSPRYITDVVDAEPLIRC 115
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 28-120 5.68e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 74.62  E-value: 5.68e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  28 DHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG---ELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDL 104
Cdd:cd18207  23 SGGRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGtprELEMHTISSKVFGDILDFAYTSRIVVRLESFPEL 102

                        90
                ....*....|....*.
gi 45593142 105 FAAAHRFQIPSIFTIC 120
Cdd:cd18207 103 MTAAKFLLMRSVIDIC 118
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-134 8.77e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 74.10  E-value: 8.77e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF-LAEPERA-GELHLEEVSPDVVAQVLHYLYTSEIALDEAS 100
Cdd:cd18271  15 LQNFREQNAFFDFNIIVKDETIPCHRCVLAACSDFFRAMFeVNMKERDdGSVTISNLSPKAVKAFLDYAYTGKAEITDDN 94

                        90       100       110
                ....*....|....*....|....*....|....
gi 45593142 101 VQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCL 134
Cdd:cd18271  95 VEMFFQMSSFLQVSLLSKACSDFLIKSIDLTNCL 128
BACK_KLHL1_like cd18444
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; ...
 131-234 1.24e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This subfamily contains Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. Members of this subfamily contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels.


Pssm-ID: 350519 [Multi-domain]  Cd Length: 106  Bit Score: 72.75  E-value: 1.24e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSgDAeaq 210
Cdd:cd18444   5 SNCLGIRSFADAQGCTDLLKVAHNYTMEHFMEVIQNQEFLLLPAEEVAKLLASDDLNVPSEETIFHALLLWVKH-DL--- 80

                        90       100
                ....*....|....*....|....
gi 45593142 211 AERQRALPTVFESVRCRLLPRAFL 234
Cdd:cd18444  81 PERKKHLAKLLALIRLPLLTPQFL 104
BTB_POZ_KLHL17_actinfilin cd18246
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-128 2.17e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also called actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GLUR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in actin-based neuronal function. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349555 [Multi-domain]  Cd Length: 139  Bit Score: 73.53  E-value: 2.17e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  26 MLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELH--LEEVSPDVVAQVLHYLYTSEIALDEASVQD 103
Cdd:cd18246  33 MRQRGLLCDIVLHVGTKEIKAHKVVLASCSPYFHAMFTNEMSESRQTHvtLHDIDPQALEQLVQYAYTAEIVVGEGNVQT 112

                        90       100
                ....*....|....*....|....*
gi 45593142 104 LFAAAHRFQIPSIFTICVSFLQKRL 128
Cdd:cd18246 113 LLPAASLLQLNGVRDACCKFLLSQL 137
BTB_POZ_KLHL1 cd18335
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-136 2.41e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton the brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349644 [Multi-domain]  Cd Length: 126  Bit Score: 72.77  E-value: 2.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPDVVAQVLHYLYTSEIALDEAS 100
Cdd:cd18335  10 MESYLKQQQLCDVILIAGNRKIPAHRLVLSAVSDYFAAMFTSDvcEAKQEEIKMEGIDPNALWDLVQFAYTGCLELKEDT 89

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45593142 101 VQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18335  90 IENLLAAACLLQLSQVVEVCCHFLMKLLHPSNCLGI 125
BTB_POZ_KLHL32 cd18261
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 11-128 2.74e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 32 (KLHL32); KLHL32, also called BTB and kelch domain-containing protein 5 (BKLHD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Deletion of KLHL32 may be ssociated with Tourette syndrome and obsessive-compulsive disorder. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349570 [Multi-domain]  Cd Length: 133  Bit Score: 72.69  E-value: 2.74e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  11 QRLYQQTLLQDGLKDMLDH----GKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPErAGELHLEEVSPDVVA 83
Cdd:cd18261   3 QRLCQSKSHKDAVLAALNQqrndGILCDITLVAEEQKFHAHKAVLAACSDYFRAMFslcMVESE-ADEVNLHGVTSLGLK 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45593142  84 QVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRL 128
Cdd:cd18261  82 QALDFAYTGQILLEPGVIQDVLAAGSHLQLLELLSLCSHYLIQEL 126
BTB_POZ_KLHL5 cd18337
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-136 3.17e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It is abundantly expressed in the ovary, adrenal gland, and thymus. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349646 [Multi-domain]  Cd Length: 130  Bit Score: 72.79  E-value: 3.17e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG--ELHLEEVSPDVVAQVLHYLYTSEIALDEAS 100
Cdd:cd18337  14 MENYLRHKQLCDVVLVAGDRRIPAHRLVLSSVSDYFAAMFTNDVREAKqeEIKMEGVEPNALWALVQYAYTGRLELKEDN 93

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45593142 101 VQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18337  94 IECLLSTACLLQLSQVVEACCKFLMKQLHPSNCLGI 129
BACK_KLHL24 cd18463
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also ...
 132-203 3.45e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6), or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation.


Pssm-ID: 350538 [Multi-domain]  Cd Length: 78  Bit Score: 70.89  E-value: 3.45e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45593142 132 NCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAG 203
Cdd:cd18463   6 NCLGIQKFADTHSLKQLFEKCKKFALENFVEVSQHEEFLELCKDELIEYISNDELVVPKEEEVFEAVMRWVY 77
BACK_KLHL19_KEAP1 cd18458
BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); ...
 131-201 8.77e-15

BACK (BTB and C-terminal Kelch) domain found in Kelch-like ECH-associated protein 1 (KEAP1); KEAP1, also termed cytosolic inhibitor of Nrf2 (INrf2), or Kelch-like protein 19 (KLHL19), is a redox-regulated substrate adaptor protein for a Cullin3-dependent ubiquitin ligase complex that targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression.


Pssm-ID: 350533 [Multi-domain]  Cd Length: 91  Bit Score: 70.02  E-value: 8.77e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRW 201
Cdd:cd18458   5 SNCIGIANFAEQHGCTELHKKAREYIYMHFSEVSQSEEFFNLSPCQLVALISRDELNVRCESEVYNAVIRW 75
BTB_POZ_KLHL2_Mayven cd18338
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-128 9.51e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 2 (KLHL2); KLHL2, also called actin-binding protein Mayven, is a novel actin-binding protein predominantly expressed in the brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349647 [Multi-domain]  Cd Length: 121  Bit Score: 70.87  E-value: 9.51e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  34 DCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRF 111
Cdd:cd18338  23 DVTIVAEDVEIAAHRVVLAACSPYFHAMFTGEmsESRAKRVRIKEVDGWTLKMLIDYVYTAEIQVTEENVQVLLPAAGLL 102

                        90
                ....*....|....*..
gi 45593142 112 QIPSIFTICVSFLQKRL 128
Cdd:cd18338 103 QLQDVKKTCCEFLESQL 119
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 24-133 9.77e-15

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 70.82  E-value: 9.77e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  24 KDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEperAGELHLEEVSPDVVAQVLHYLYTSEIAL--DEASV 101
Cdd:cd18303  10 ASLFDKELYSDITIKLADKSIPAHKFVLAARSEKWSNENLAS---TNELDLSDISYEVVLALLRWLYTDELDLtlDDEFL 86

                        90       100       110
                ....*....|....*....|....*....|..
gi 45593142 102 QDLFAAAHRFQIPSIFTICVSFLQKRLCLSNC 133
Cdd:cd18303  87 LELMKAAKRFQLTDLVERCERALMSSVNVDNC 118
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-132 1.50e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 70.62  E-value: 1.50e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLqDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLY 90
Cdd:cd18251   6 HSQALL-DGLVALRDSGILFDVVLVVEGKPIEAHRILLAASCDYFRGMFaggLREMQQT-EVLIHGVSYNAMCKILDFIY 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45593142  91 TSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSN 132
Cdd:cd18251  84 TSELELSLDNVQETLTAACQLQIPEVIGFCCDFLMSWVDNEN 125
BACK_KEL_like cd18508
BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch ...
 131-201 1.51e-14

BACK (BTB and C-terminal Kelch) domain found in Drosophila melanogaster ring canal kelch protein (KEL) and similar proteins; KEL, also termed kelch short protein, is a component of ring canals that regulates the flow of cytoplasm between cells. It binds actin and may be involved in the regulation of cytoplasm flow from nurse cells to the oocyte during oogenesis.


Pssm-ID: 350583 [Multi-domain]  Cd Length: 77  Bit Score: 68.97  E-value: 1.51e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRW 201
Cdd:cd18508   3 TNCLGIHEFADAHSCVELEEAAQNYIYQHFNEVIQGEEFLSLDHESLTELISSDRLNVPSEERVYEAAVAW 73
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-132 1.65e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 70.25  E-value: 1.65e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  18 LLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPE--RAGELHLEEVSPDVVAQVLHYLYTSEIA 95
Cdd:cd18279   4 RLAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAMFEHEMEesKKNRVEINDVDPEVFKEMMRFIYTGKAP 83

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 45593142  96 LDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSN 132
Cdd:cd18279  84 NLDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-129 1.81e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 70.05  E-value: 1.81e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  19 LQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFL--AEPERAGELHLEEVSPDVVAQVLHYLYTSEI-- 94
Cdd:cd18280   1 LGQHFGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLFgpMREENEGEIVIEDVEPPVFKALLHFIYKDELpd 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 45593142  95 ----------ALDEASVQDLFAAAHRFQIPSIFTICVSflqkRLC 129
Cdd:cd18280  81 dvepagsdssSLDTTMAQHLLAAADRYALERLRLLCES----RLC 121
BTB_POZ_ZBTB7 cd18198
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-125 3.07e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7 (ZBTB7); There are three ZBTB7 isoforms: ZBTB7A, ZBTB7B, and ZBTB7C. ZBTB7A is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. ZBTB7B is a transcriptional regulator of extracellular matrix gene expression. ZBTB7C is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. ZBTB7 isoforms contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349507 [Multi-domain]  Cd Length: 120  Bit Score: 69.51  E-value: 3.07e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  22 GLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEP--ERAGELHLEEVSPDVVAQVLHYLYTSEIALDEA 99
Cdd:cd18198  15 GLNEQRTQGLLCDVVILVQGREYRTHRSVLAACSQYFKKLFTSGAvvDQQNVYEIDFVSPEALTALLEFAYTATLTVSTA 94

                        90       100
                ....*....|....*....|....*.
gi 45593142 100 SVQDLFAAAHRFQIPSIFTICVSFLQ 125
Cdd:cd18198  95 NVGDILSAARLLEIPCVSHVCAEILD 120
BTB_POZ_KLHL34 cd18264
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 26-133 5.95e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 34 (KLHL34); KLHL34 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The methylation status of KLHL34 cg14232291 appears to be predictive of pathologic response to preoperative chemoradiation therapy in rectal cancer patients. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349573 [Multi-domain]  Cd Length: 136  Bit Score: 69.05  E-value: 5.95e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  26 MLDHGKFL-DCVVRAGEREFPCHRLVLAACSPYFRARF--LAEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQ 102
Cdd:cd18264  21 SLRAEGFLcDVVLEAEGNEFPAHRSLLACSSDYFRALFkdYTQESKARVIHLPVVSAAGLQRVLDFIYTSWLSLSLDTLE 100

                        90       100       110
                ....*....|....*....|....*....|.
gi 45593142 103 DLFAAAHRFQIPSIFTICVSFLQKRLCLSNC 133
Cdd:cd18264 101 DTLEAASYLQVTEAIGLCSQYLINNLAPENC 131
BACK_KBTBD3 cd18480
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 130-201 6.77e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also termed BTB and kelch domain-containing protein 3 (BKLHD3), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350555 [Multi-domain]  Cd Length: 82  Bit Score: 67.35  E-value: 6.77e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45593142 130 LSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRW 201
Cdd:cd18480   3 LSNCLQLLSFAESYGSTRLLDHALEFVMQHFSLLSQSQEFLELNFEVLEKILEADELNVPDEEAVLKAVLRW 74
BACK_KLHL29_KBTBD9 cd18468
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also ...
 131-201 7.40e-14

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 29 (KLHL29); KLHL29, also termed Kelch repeat and BTB domain-containing protein 9 (KBTBD9), belongs to the KLHL family. Its function remains unclear. A nuclear receptor subfamily 5, group A, member 2 (NR5A2)-Kelch-like family member 29 (KLHL29) fusion transcript may participate in the origin or progression of some colon cancers.


Pssm-ID: 350543 [Multi-domain]  Cd Length: 102  Bit Score: 67.82  E-value: 7.40e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRW 201
Cdd:cd18468   3 SNCLGIWALAEALQCTELHNMAKAYALQNFPDVARQEEILSISKDDIVEYLSHDSLNTKAEELVFETAIKW 73
BTB_POZ_KLHL11 cd18241
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-133 1.02e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349550 [Multi-domain]  Cd Length: 135  Bit Score: 68.34  E-value: 1.02e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  29 HGKFLD---CVVRAGEREFPCHRLVLAACSPYFrARFLA---EPERAGELHLEEVS------PDVVAQVLHYLYTSEIAL 96
Cdd:cd18241  20 QGLFCDitlAFGGAGGREFRAHRSVLAAATEYF-TPLLSgqfSESRSGRVEMRKWSsepgpdPDTVEAVIQYMYTGRIRV 98

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 45593142  97 DEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNC 133
Cdd:cd18241  99 STGNVHEVLELADRFLLIRLKEFCGEFLKKKLNLSNC 135
BACK_KLHL4 cd18510
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares ...
 131-234 1.03e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350585 [Multi-domain]  Cd Length: 106  Bit Score: 67.63  E-value: 1.03e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSgDAEaq 210
Cdd:cd18510   5 SNCLGIRSFGDAQGCTELLKVAHSYTMEHFLEVIKNQEFLLLPASEIVKLLASDDINVPDEETIFQALMMWVRH-DLQ-- 81

                        90       100
                ....*....|....*....|....
gi 45593142 211 aERQRALPTVFESVRCRLLPRAFL 234
Cdd:cd18510  82 -NRQKDLGMLLSYIRLPLLPPQLL 104
BTB_POZ_ZBTB5 cd18196
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-127 1.15e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 5 (ZBTB5); ZBTB5 is a POZ domain Kruppel-like zinc finger (POK) family transcription repressor of cell cycle arrest gene p21 and a potential proto-oncogene stimulating cell proliferation. ZBTB5 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349505 [Multi-domain]  Cd Length: 126  Bit Score: 68.15  E-value: 1.15e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  29 HGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAePERAGELHLEEVSPDVV-----AQVLHYLYTSEIALDEASVQD 103
Cdd:cd18196  18 HGQLCDCVIVVGNRHFKAHRSVLAACSTHFRALFTV-AEGDQTMNMIQLDSEVVtaeafAALIDMMYTSTLMLGESNVMD 96

                        90       100
                ....*....|....*....|....
gi 45593142 104 LFAAAHRFQIPSIFTICVSFLQKR 127
Cdd:cd18196  97 VLLAASHLHLNSVVKACKHYLTTR 120
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-128 1.50e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 67.58  E-value: 1.50e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  18 LLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE---------LHLEEVSPDVVAQVLHY 88
Cdd:cd18228   5 ELLGKLNSLRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKLVGQASPRLVlvspagkcvLDLHHVTVTGFAPLLEY 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45593142  89 LYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRL 128
Cdd:cd18228  85 AYTSTLSINTENIIDVLAAASYMQMFNVANTCSEFMKSSI 124
BACK_KLHL33 cd18472
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs ...
 131-202 1.63e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 33 (KLHL33); KLHL33 belongs to the KLHL family. Its function remains unclear. KLHL33 SNPs may be associated with prostate cancer risk.


Pssm-ID: 350547 [Multi-domain]  Cd Length: 75  Bit Score: 65.87  E-value: 1.63e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWA 202
Cdd:cd18472   4 ANCLELWAFADAATLPRLAAAARAFALKHFAEVAASAAFLSLPLARLLELLRSDELEVAEEEAVFEAAVRWL 75
BACK_KBTBD2 cd18479
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 132-225 1.74e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulating the insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation.


Pssm-ID: 350554 [Multi-domain]  Cd Length: 96  Bit Score: 66.62  E-value: 1.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 132 NCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWagsgdAEAQA 211
Cdd:cd18479   5 NCVRLLSFADLFSCEELKQSAKRMVEHKFTAVYHQEAFMQLSHDLLIDILSSDNLNVEKEETVREAAMLW-----LEYNT 79

                        90
                ....*....|....*
gi 45593142 212 E-RQRALPTVFESVR 225
Cdd:cd18479  80 EsRSQYLSSVLSQIR 94
BTB_POZ_KLHL15 cd18244
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-136 2.18e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for the Cullin3 E3 ubiquitin-protein ligase complex that targets the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. KLHL15 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349553 [Multi-domain]  Cd Length: 137  Bit Score: 67.67  E-value: 2.18e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  22 GLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE-PER-AGELHLEEVSPDVVAQVLHYLYTSEIALDEA 99
Cdd:cd18244  20 GFRALYEEGLLLDVTLVIEDHQFQAHKALLATQSDYFRIMFTADmRERdQDKIHLKGLTATGFSHVLQFMYYGTIELSML 99

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 45593142 100 SVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18244 100 TVHEILQAAMYVQLTEVVKFCCSFLLAKICLDNCAEI 136
BACK_KBTBD8 cd18483
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 132-230 2.56e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 8 (KBTBD8); KBTBD8, also called T-cell activation kelch repeat protein (TA-KRP), is a BTB-kelch family protein that is located in the Golgi apparatus and translocates to the spindle apparatus during mitosis. It acts as a substrate-specific adaptor for a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification. The BCR(KBTBD8) complex monoubiquitylates NOLC1 and its paralogue TCOF1, the mutation of which underlies the neurocristopathy Treacher Collins syndrome.


Pssm-ID: 350558 [Multi-domain]  Cd Length: 97  Bit Score: 66.04  E-value: 2.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 132 NCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgsgdAEAQA 211
Cdd:cd18483   5 NSIGVFIFADHYGHQELKERSQDYIRKKFLSVTKEQEFLHLTKDQLISILNSDDLNVEKEEHVYESIIHWF----EHEQS 80

                        90
                ....*....|....*....
gi 45593142 212 ERQRALPTVFesVRCRLLP 230
Cdd:cd18483  81 KREMHLPEIF--AKCIRMP 97
BTB_POZ_KLHL36 cd18266
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-134 3.25e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 36 (KLHL36); KLHL36 may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349575 [Multi-domain]  Cd Length: 135  Bit Score: 66.84  E-value: 3.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  15 QQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEEVSPDVVA--QVLHYLYTS 92
Cdd:cd18266   8 HSNLVLQGLNEQRQRGLFCDVVLVADEQRVPAHRNLLAVCSDYFNSMFTIGMREAHQKEVELVGASYIGlkAVIDFLYSS 87

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45593142  93 EIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCL 134
Cdd:cd18266  88 ELPLDGGNIDYVLETAHLLQIWKVVDFCCEYLENEVSEENYL 129
BACK_KLHL6 cd18446
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a ...
 132-239 3.96e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 6 (KLHL6); KLHL6 is a BTB-kelch protein with a lymphoid tissue-restricted expression pattern. It belongs to the KLHL gene family, which is composed of an N-terminal BTB-POZ domain and four to six Kelch motifs in tandem. It is involved in B-lymphocyte antigen receptor signaling and germinal center formation.


Pssm-ID: 350521 [Multi-domain]  Cd Length: 108  Bit Score: 65.95  E-value: 3.96e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 132 NCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgsgdAEAQA 211
Cdd:cd18446   5 NCVGILRLADAHSLESLKKQVQNYIIQNFSQVLNHEEFLELPVDILCHILKSDDLYVTEEEQVFETVMRWV----RYKES 80

                        90       100
                ....*....|....*....|....*...
gi 45593142 212 ERQRALPTVFESVRCRLLPRAFLESRVE 239
Cdd:cd18446  81 ERLPLLPRVLENVRLPLLDPWYFVETVE 108
BTB_POZ_ZBTB47_ZNF651 cd18231
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-127 4.38e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349540 [Multi-domain]  Cd Length: 115  Bit Score: 66.10  E-value: 4.38e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  12 RLYQQTLLQDGLKDmldhgkfLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPE-RAGELHLEEVSPDVVAQVLHYLY 90
Cdd:cd18231   3 RLNEQRLFQPDLCD-------VDIVLVRQRSTFPAHKGVLAAYSQFFHSLFTQNKQlQRVELSLEALTSQGLQQILNFIY 75

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 45593142  91 TSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKR 127
Cdd:cd18231  76 TSKLLVNSCNVQDVLNAAAVLQMNDIAASCQELIDSR 112
BACK_KLHL28_BTBD5 cd18467
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also ...
 132-229 4.47e-13

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also termed BTB/POZ domain-containing protein 5 (BTBD5), belongs to the KLHL family. Its function remains unclear.


Pssm-ID: 350542 [Multi-domain]  Cd Length: 99  Bit Score: 65.35  E-value: 4.47e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 132 NCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSgDAEaqa 211
Cdd:cd18467   5 NCIGISRFAETYGCHDLYLAANKYICQNFEDVCQTEEFFELTHAELDEIVSNDCLNVVTEETVFYALESWIKY-DVQ--- 80

                        90
                ....*....|....*...
gi 45593142 212 ERQRALPTVFESVRCRLL 229
Cdd:cd18467  81 ERQKYLAQLLHCVRLPLL 98
BTB_POZ_ZBTB3-like cd18194
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-128 6.35e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349503 [Multi-domain]  Cd Length: 128  Bit Score: 66.00  E-value: 6.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLQdGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHL--EEVSPDVVAQVLHYLYT 91
Cdd:cd18194   6 HSRQLLQ-CLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLnsDIVTAPAFGLLLDFMYE 84

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 45593142  92 SEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRL 128
Cdd:cd18194  85 GRLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKA 121
BTB_POZ_ZBTB7A cd18326
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-124 1.01e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349635 [Multi-domain]  Cd Length: 120  Bit Score: 64.96  E-value: 1.01e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  22 GLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFL--AEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEA 99
Cdd:cd18326  15 SLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTsgAVVDQQNVYEIDFVSAEALTALLDFAYTATLTVSTS 94

                        90       100
                ....*....|....*....|....*
gi 45593142 100 SVQDLFAAAHRFQIPSIFTICVSFL 124
Cdd:cd18326  95 NVGDILSAARLLEIPAVSHVCADLL 119
BTB_POZ_KLHL31_KBTBD1 cd18260
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-134 1.05e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 31 (KLHL31); KLHL31 is also called BTB and kelch domain-containing protein 6 (BKLHD6), Kelch repeat and BTB domain-containing protein 1 (KBTBD1), or Kelch-like protein KLHL. It is a transcriptional repressor in the MAPK/JNK signaling pathway to regulate cellular functions. Overexpression inhibits the transcriptional activities of both the TPA-response element (TRE) and serum response element (SRE). It is also a novel modulator of canonical Wnt signaling, which is important for vertebrate myogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349569 [Multi-domain]  Cd Length: 120  Bit Score: 65.22  E-value: 1.05e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLQdGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPE-RAGELHleEVSPDVVAQVLHYLYTS 92
Cdd:cd18260   1 YGANLLE-GLNRMRQERFLCDLTIATKTKSFDVHKVVMASCSEYFRNILKKDPSlQRVELN--DISPLGLATVITYAYTG 77

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45593142  93 EIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCL 134
Cdd:cd18260  78 KLTLSLYTIGSTISAASYLQIHALVKMCCDFLMQEMNVENCM 119
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-111 1.56e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 64.57  E-value: 1.56e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  18 LLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLYTSEI 94
Cdd:cd18287   8 FLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggMRESQQS-EIELKDTNAEAFKALLKYIYTGRL 86

                        90       100
                ....*....|....*....|
gi 45593142  95 AL---DEASVQDLFAAAHRF 111
Cdd:cd18287  87 TLtdlKEDVLLDVLGLAHQY 106
BACK_KLHL25_ENC2 cd18514
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also ...
 131-230 1.62e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1).


Pssm-ID: 350589 [Multi-domain]  Cd Length: 99  Bit Score: 63.71  E-value: 1.62e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSgDAEaq 210
Cdd:cd18514   4 SNCLGMMLLSDAHQCRRLYELSWRMCLVHFETVRESEDFYSLSKDKLLDLISSDELEIEDEQVVFNAVLQWVKY-DLE-- 80

                        90       100
                ....*....|....*....|
gi 45593142 211 aERQRALPTVFESVRCRLLP 230
Cdd:cd18514  81 -KRKDYLPELLRNVRLALLP 99
BACK_KLHL38 cd18476
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs ...
 131-227 1.63e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 38 (KLHL38); KLHL38 belongs to the KLHL family. Its function remains unclear. The klhl38 gene has recently been identified as a possible diapause (a temporary arrest of development during early ontogeny) gene, as it is significantly up-regulated during diapause. It may also be involved in chicken preadipocyte differentiation.


Pssm-ID: 350551 [Multi-domain]  Cd Length: 99  Bit Score: 63.99  E-value: 1.63e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLnVEKEEAVFEAVMRWAgSGDAEAq 210
Cdd:cd18476   4 SNCLSMIRLSEILNCETLKKKAKDMALQCFPDVAASEDLKELCASELLDYLGDDEL-CGEEEQVFETLMVWI-RHDPKA- 80

                        90
                ....*....|....*..
gi 45593142 211 aeRQRALPTVFESVRCR 227
Cdd:cd18476  81 --RKGYIHDLFKKVRLQ 95
BACK_KLHL20 cd18459
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also ...
 131-229 2.78e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also termed Kelch-like ECT2-interacting protein (KLEIP), or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis.


Pssm-ID: 350534 [Multi-domain]  Cd Length: 100  Bit Score: 63.22  E-value: 2.78e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGdaeaQ 210
Cdd:cd18459   5 SNCLGIRAFADTHACRELLRIADKFTQHNFQEVMESEEFMLLPVNQLIDIISSDELNVRSEEQVFNAVMAWVKYN----I 80

                        90
                ....*....|....*....
gi 45593142 211 AERQRALPTVFESVRCRLL 229
Cdd:cd18459  81 QERRPHLPQVLQHVRLPLL 99
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 12-136 4.03e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 64.15  E-value: 4.03e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  12 RLYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE--LHLEEVSPDVVAQVLHYL 89
Cdd:cd18272  12 RSHSSRVAQSIMDLCLEDGLFADVTISVEGKEFQLHRLVLSAQSCFFRSMFTSNLKEARNrvIELKDVSESVFQLLVDYI 91

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 45593142  90 YTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18272  92 YHGTVKLRVEELQETYEVADMYQLTALFEECSRFLARTVQVRNCLQV 138
BACK_KBTBD12 cd18485
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 131-228 4.68e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 12 (KBTBD12); KBTBD12, also termed Kelch domain-containing protein 6 (KLHDC6), is a BTB-Kelch family protein. Its function remains unclear.


Pssm-ID: 350560 [Multi-domain]  Cd Length: 100  Bit Score: 62.44  E-value: 4.68e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGsgdaEAQ 210
Cdd:cd18485   4 SNCLGIYYFAKQIGAEDLSDRARKYLYQHFTEVCLHEEVLEIEAHQLLTLIKSDDLNVSREESILDLVLRWVN----HNR 79

                        90
                ....*....|....*...
gi 45593142 211 AERQRALPTVFESVRCRL 228
Cdd:cd18485  80 KSRVQHLVELLKQVRLEL 97
BACK_KLHL7 cd18447
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a ...
 131-201 4.71e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a BTB-Kelch protein that constitutes a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 cause autosomal-dominant retinitis pigmentosa.


Pssm-ID: 350522 [Multi-domain]  Cd Length: 98  Bit Score: 62.38  E-value: 4.71e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRW 201
Cdd:cd18447   5 SNCLGISVLAECLDCPELKATADDFIHQHFTEVYKTDEFLQLDVKRVTHLLNQDTLTVRAEDQVYDAAVRW 75
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-124 4.91e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 62.65  E-value: 4.91e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  23 LKDMLDHGKFLDCVVRAGEREFP--CHRLVLAACSPYFRARFLAEPERAG---ELHLEEVSPDVVAQVLHYLYTSEIALD 97
Cdd:cd18294   5 MKSLINNPEFSDVKFLVGPERQEifAHKCILAARCEVFRAMFLTGPQKEStqsPLVLSDIEPEVFRAVLEFIYTNCVTLS 84

                        90       100
                ....*....|....*....|....*..
gi 45593142  98 EASVQDLFAAAHRFQIPSIFTICVSFL 124
Cdd:cd18294  85 NHTVIEVLAAAVEYGLDELRKLCERFI 111
BACK_KLHL16_gigaxonin cd18455
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, ...
 132-201 6.41e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 16 (KLHL16); Gigaxonin, also termed Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy.


Pssm-ID: 350530 [Multi-domain]  Cd Length: 97  Bit Score: 61.95  E-value: 6.41e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 132 NCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRW 201
Cdd:cd18455   4 NCIGIRDFAERFSCPHVHYVATEYLETHFRDVSSTEEFLELSPEKLKELLSRDKLNVGNEEYIFEAVLRW 73
BACK_KLHL1 cd18509
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a ...
 131-234 7.13e-12

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 1 (KLHL1); KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. It may play a role in organizing the actin cytoskeleton in brain cells. KLHL1 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein.


Pssm-ID: 350584 [Multi-domain]  Cd Length: 106  Bit Score: 62.35  E-value: 7.13e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgsgdAEAQ 210
Cdd:cd18509   5 SNCLGIRAFADAQGCIELMKVAHSYTMENIMEVIRNQEFLLLPAEELHKLLASDDVNVPDEETIFHALMMWV----KYDM 80

                        90       100
                ....*....|....*....|....
gi 45593142 211 AERQRALPTVFESVRCRLLPRAFL 234
Cdd:cd18509  81 QRRCSDLSMLLAYIRLPLLPPQLL 104
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-132 8.71e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 62.71  E-value: 8.71e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  19 LQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPE--RAGELHLEEVSPDVVAQVLHYLYTSEIAL 96
Cdd:cd18343   8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEesKKNRVEINDVDPEVFKEMMRFIYTGKAPN 87

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45593142  97 DEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSN 132
Cdd:cd18343  88 LDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_KLHL14_printor cd18243
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-132 1.15e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 14 (KLHL14); KLHL14 is also called protein interactor of Torsin-1A (TOR1A), protein interactor of torsinA, or Printor. It is a novel torsinA-interacting protein that preferentially interacts with ATP-free form of TOR1A and is implicated in dystonia pathogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349552 [Multi-domain]  Cd Length: 130  Bit Score: 62.37  E-value: 1.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLQdGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFlaepeRAGELHLEEVSPDVVAQVLHYLYTSE 93
Cdd:cd18243  15 HSDNLLH-GLNLLWRKQLFCDVTLTAQGQQFHCHKAVLASCSQYFRSLF-----SINNLVLQGCSSIGLRLVLEYLYTAN 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 45593142  94 IALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSN 132
Cdd:cd18243  89 VTLSLDTVEEVLSVSKILHIPQVTKLCVQFLNDQISVQN 127
BTB_POZ_ZBTB31_myoneurin cd18217
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-120 1.53e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in myoneurin; Myoneurin, also called zinc finger and BTB domain-containing protein 31 (ZBTB31), is a novel member of the BTB/POZ-zinc finger family highly expressed in the neuromuscular system and is associated with neuromuscular junctions during the late embryonic period. It may function as a synaptic gene regulator. Myoneurin contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349526 [Multi-domain]  Cd Length: 111  Bit Score: 61.31  E-value: 1.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  18 LLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEEVSPDVVAQVLHYLYTSEIALD 97
Cdd:cd18217   4 QLLERLNKQREAGFLCDCTIVIGQFQFKAHRNVLAAFSEYFGAQYKDTEDNIVFLDQSQVSADGFQKLLEFIYTGNLNLD 83

                        90       100
                ....*....|....*....|...
gi 45593142  98 EASVQDLFAAAHRFQIPSIFTIC 120
Cdd:cd18217  84 SWNVAEIHQAASYLGMEEVVAKC 106
BACK_KLHL30 cd18469
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs ...
 131-233 1.79e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 30 (KLHL30); KLHL30 belongs to the KLHL family. Its function remains unclear. Differential expression of the KLHL30 gene has been observed in glioblastoma multiforme versus normal brain.


Pssm-ID: 350544 [Multi-domain]  Cd Length: 104  Bit Score: 60.93  E-value: 1.79e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGsgdaEAQ 210
Cdd:cd18469   6 TNCLGICEFGETHGCPEVAAKAWSFLLENFEAVSQEEEFLQLEKERLVACLGDDLLQVRDEQSRLEAVLRWVG----HDP 81

                        90       100
                ....*....|....*....|...
gi 45593142 211 AERQRALPTVFESVRCRLLPRAF 233
Cdd:cd18469  82 QARAAHLPELLSLVHLSLLTDQY 104
BACK_KLHL25_like cd18464
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The ...
 131-230 2.04e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL25 and KLHL37; The family includes KLHL25 and KLHL37. KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350539 [Multi-domain]  Cd Length: 98  Bit Score: 60.59  E-value: 2.04e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgSGDAEaq 210
Cdd:cd18464   3 SNCLGMLLLSDAHQCQRLYELSWRMCLANFTTLRKTEDFLSLPKDKLLELVSSEELEVEDERLVYEAVIGWI-RYDLP-- 79

                        90       100
                ....*....|....*....|
gi 45593142 211 aERQRALPTVFESVRCRLLP 230
Cdd:cd18464  80 -RRHEVLPELLRSVRLALLP 98
BTB_POZ_calicin cd18307
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-123 2.07e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa. It contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349616 [Multi-domain]  Cd Length: 97  Bit Score: 60.59  E-value: 2.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  32 FLDCVVRAGEREFPCHRLVLAACSPYFRARFLA-EPERAGELHL----EEVSPDVVAQVLHYLYTSEIALDEASVQDLFA 106
Cdd:cd18307   1 FCDVVISVDNHSFAAHRNVLAAVSPFVKSLISSnDMKATDELSItidcDYLSPETVEQLLDYFYTGKIVISEKNVEDLLK 80

                        90
                ....*....|....*..
gi 45593142 107 AAHRFQIPSIFTICVSF 123
Cdd:cd18307  81 GAKYFNIPRLKDHCVDF 97
BTB_POZ_ZBTB7C_ZBTB36 cd18328
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-125 2.28e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349637 [Multi-domain]  Cd Length: 120  Bit Score: 61.44  E-value: 2.28e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  22 GLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEP--ERAGELHLEEVSPDVVAQVLHYLYTSEIALDEA 99
Cdd:cd18328  15 SLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTlaDQPYVYEIDFVTPEALSAILEFAYTSTLTITTS 94

                        90       100
                ....*....|....*....|....*.
gi 45593142 100 SVQDLFAAAHRFQIPSIFTICVSFLQ 125
Cdd:cd18328  95 NVKHILNAAQMLEIQCIINVCLEIMD 120
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 32-113 2.44e-11

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 59.87  E-value: 2.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  32 FLDCVVRAGEREFPCHRLVLAACSPYFRARFLA-EPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHR 110
Cdd:cd18315   1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKEtPPDEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLAEL 80


                ...
gi 45593142 111 FQI 113
Cdd:cd18315  81 LQI 83
BTB_POZ_ZBTB3 cd18323
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-127 2.44e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349632 [Multi-domain]  Cd Length: 128  Bit Score: 61.38  E-value: 2.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLQDgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE--LHLEEVSPDVVAQVLHYLYT 91
Cdd:cd18323   6 HSRHLLQS-LREQRHQGFLCDCTVLVGSTQFLAHRAVLASCSPFFHMFYKEQLDKRDLvcINNEIVTAPAFSLLLEFMYE 84

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45593142  92 SEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKR 127
Cdd:cd18323  85 GRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRLQAR 120
BTB_POZ_KLHL9_13 cd18239
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-133 2.89e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13; KLHL9 and KLHL13 (also called BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes, thereby coordinating faithful mitotic progression and completion of cytokinesis. They contain a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349548 [Multi-domain]  Cd Length: 128  Bit Score: 61.36  E-value: 2.89e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  40 GEREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSI 116
Cdd:cd18239  33 GDETFPVHRAMMASASDYFKAMFtggMKEQELM-CIKLHGVSKIGLKNIIDFIYTAKLSLNMDNLQDTLEAASFLQILPV 111

                        90
                ....*....|....*..
gi 45593142 117 FTICVSFLQKRLCLSNC 133
Cdd:cd18239 112 LDFCKVLLISGVTLENC 128
BACK_KLHL27_IPP cd18466
BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide ...
 131-230 3.98e-11

BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also termed Kelch-like protein 27 (KLHL27), is an actin-binding protein that may play a role in organizing the actin cytoskeleton.


Pssm-ID: 350541 [Multi-domain]  Cd Length: 103  Bit Score: 60.19  E-value: 3.98e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgsgdAEAQ 210
Cdd:cd18466   4 ANCIGIFQFSEQIACHDLLEFTENYIHVHFLEVQSGEEFLGLTKDQLVKILRSEELSIEDEYQVFTAAMEWI----LKDV 79

                        90       100
                ....*....|....*....|
gi 45593142 211 AERQRALPTVFESVRCRLLP 230
Cdd:cd18466  80 GKRKKHVVEVLEPVRFPLLP 99
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-123 7.44e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 59.56  E-value: 7.44e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   5 LEQAEEQRlyqqtllQDGLkdmldhgkFLDCVVRAGEREFPCHRLVLAACSPYFRARFLaepERAGELHLEEVSPDVVAQ 84
Cdd:cd18206  10 LEQLNQQR-------QLGL--------LCDCTFVVDGVDFKAHKAVLAACSEYFRMLFV---DQKDVVHLDISNAAGLGQ 71

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 45593142  85 VLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSF 123
Cdd:cd18206  72 VLEFMYTAKLSLSPENVDDVLAVATFLQMQDIVTACHAL 110
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 129-183 7.68e-11

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 57.67  E-value: 7.68e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 45593142 129 CLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISS 183
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLSS 55
BTB_POZ_ZBTB49 cd18233
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-125 8.09e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 49 (ZBTB49); ZBTB49, also called zinc finger protein 509 (ZNF509), is a transcription factor that inhibits cell proliferation by activating either CDKN1A/p21 transcription or RB1 transcription. There are four ZNF509 isoforms generated by alternative splicing. Short ZNF509 (ZNF509S1, -S2 and -S3) isoforms contain one or two out of the seven zinc-fingers contained in long ZNF509 (ZNF509L). ZBTB49 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349542 [Multi-domain]  Cd Length: 112  Bit Score: 59.52  E-value: 8.09e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   5 LEQAEEQRLyqqtllqdglkdmldHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGEL-HLEEVSPDVVA 83
Cdd:cd18233   6 LQQLHEQRI---------------QGLLCDCMLVVKGVCFKAHKNVLAAFSQYFRSLFQNSSSQKNDVfHLDIKNVGGIG 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45593142  84 QVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQ 125
Cdd:cd18233  71 QILDFMYTSHLDLNQDNVQVMLDIAQCLQVQNVLNMCYTFLK 112
BTB_POZ_ZBTB48_TZAP_KR3 cd18232
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-123 8.51e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349541 [Multi-domain]  Cd Length: 108  Bit Score: 59.39  E-value: 8.51e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARFlaEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAH 109
Cdd:cd18232  16 GQYCDATLDVGGRVFKAHWSVLACCSHFFQSLY--GDGTSGSVVLPESFAEVFGLLLDFFYTGELALTRENRDRVLLAAK 93

                        90
                ....*....|....
gi 45593142 110 RFQIPSIFTICVSF 123
Cdd:cd18232  94 ELRVPEAVELCQRF 107
BACK_KLHL5 cd18511
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares ...
 131-234 8.58e-11

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 5 (KLHL5); KLHL5 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. It is abundantly expressed in ovary, adrenal gland, and thymus.


Pssm-ID: 350586 [Multi-domain]  Cd Length: 106  Bit Score: 59.31  E-value: 8.58e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgSGDAEaq 210
Cdd:cd18511   5 SNCLGIRSFADAQGCTDLHKVAHNYTMEHFMEVIRNQEFLLLPASEIAKLLASDDMNIPNEETILNALLSWV-RHDVE-- 81

                        90       100
                ....*....|....*....|....
gi 45593142 211 aERQRALPTVFESVRCRLLPRAFL 234
Cdd:cd18511  82 -QRRKDLSKLLAYIRLPLLAPQFL 104
BTB_POZ_ZBTB7B_ZBTB15 cd18327
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-125 8.61e-11

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349636 [Multi-domain]  Cd Length: 127  Bit Score: 59.86  E-value: 8.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  19 LQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGEL---------HLEEVSPDVVAQVLHYL 89
Cdd:cd18327  12 LLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGSGDLgagggqdvcELDFVGPEALGALLEFA 91

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45593142  90 YTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQ 125
Cdd:cd18327  92 YTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-128 1.39e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 58.84  E-value: 1.39e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  40 GEREFPCHRLVLAACSPYFRARFLAE-PERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFT 118
Cdd:cd18349  20 ASQRVPAHKYVLAVGSSVFYAMFYGDlAEVKSEIHIPDVEPAAFLILLKYMYSDEIDLEADTVLATLYAAKKYIVPALAK 99

                        90
                ....*....|
gi 45593142 119 ICVSFLQKRL 128
Cdd:cd18349 100 ACVNFLETSL 109
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-132 1.46e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 58.96  E-value: 1.46e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  19 LQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPE--RAGELHLEEVSPDVVAQVLHYLYTSEIAL 96
Cdd:cd18342   9 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSPVFSAMFEHEMEesKKNRVEINDVEPEVFKEMMCFIYTGKAPN 88

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45593142  97 DEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSN 132
Cdd:cd18342  89 LDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 124
BTB_POZ_ZBTB4 cd18195
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-116 1.72e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 4 (ZBTB4); ZBTB4, also called KAISO-like zinc finger protein 1 (KAISO-L1), is a transcriptional repressor with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3' but can also bind to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It can also bind specifically to a single methyl-CpG pair and can bind hemimethylated DNA but with a lower affinity compared to methylated DNA. ZBTB4 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349504 [Multi-domain]  Cd Length: 124  Bit Score: 58.75  E-value: 1.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   5 LEQAEEQRLyqqtllqdglkdmldHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE-------------PERAGE 71
Cdd:cd18195   6 LLQLNEQRL---------------RGLFCDVTLIAGDTKFRAHRSVLAASSPYFRELLSSPlplgaaavaaapgATQSPE 70

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 45593142  72 --LHLEEVSPDVVAQVLHYLYTSEIALD-EASVQDLFAAAHRFQIPSI 116
Cdd:cd18195  71 rvLELPGVKAGVFSDVLNFIYSSRVALPgSAAAKELGAAGKRLGIPFL 118
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-128 1.78e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 58.18  E-value: 1.78e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  40 GEREFPCHRLVLAACSPYFRARF---LAEPERagELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSI 116
Cdd:cd18282  19 GTQRIPAHKYVLATGSSVFYAMFyggLAENKN--EIEIPDVEPAAFLNLLRYLYCDEIDLEPDTVLATLYAAKKYLVPHL 96

                        90
                ....*....|..
gi 45593142 117 FTICVSFLQKRL 128
Cdd:cd18282  97 ARACVQFLETSL 108
BACK_KLHL17 cd18456
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also ...
 131-233 1.95e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 17 (KLHL17); KLHL17, also termed actinfilin, is a substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes. It acts as a Cullin 3 (Cul3) substrate adaptor that links GluR6 to the E3 ubiquitin-ligase complex, and mediates the ubiquitination and subsequent degradation of GLUR6. It may play a role in the actin-based neuronal function.


Pssm-ID: 350531 [Multi-domain]  Cd Length: 102  Bit Score: 58.09  E-value: 1.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgSGDAEAq 210
Cdd:cd18456   4 SNCLGIRGFADTHSCSDLLKSAHKYVLQHFVEVSKTEEFMLLPLKQVLDLISSDSLNVPSEEEVYRAVLSWV-KHDVDG- 81

                        90       100
                ....*....|....*....|...
gi 45593142 211 aeRQRALPTVFESVRCRLLPRAF 233
Cdd:cd18456  82 --RRQHVPRLMKCVRLPLLSRDF 102
BACK_KLHL35 cd18474
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs ...
 131-201 2.16e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 35 (KLHL35); KLHL35 belongs to the KLHL family. Its function remains unclear. Hypermethylation of KLHL35 is associated with hepatocellular carcinoma and abdominal aortic aneurysm.


Pssm-ID: 350549 [Multi-domain]  Cd Length: 79  Bit Score: 57.13  E-value: 2.16e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRW 201
Cdd:cd18474   4 NNCLALLAAADALHCAPLQEHCIRVLLRDFAQAARHPSFLKLELQLVLELLADDSLAVRSEEVVLEAALRW 74
PLN02153 PLN02153
epithiospecifier protein
 388-596 3.52e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 61.93  E-value: 3.52e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  388 LDSEWLGMPPL----PSPRCLFGLGEALNSIYVVGGrEIKDGERCLDSVMCYDRLSFKWG----ESDPLPYVVYGHTVLS 459
Cdd:PLN02153   5 LQGGWIKVEQKggkgPGPRCSHGIAVVGDKLYSFGG-ELKPNEHIDKDLYVFDFNTHTWSiapaNGDVPRISCLGVRMVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  460 HMDLVYVIGGKGSDRKcLNKMCVYDPKKFEWKELAPMQT-----ARSLFGATVHDGRIIVAAGVTDTGLTSSA------E 528
Cdd:PLN02153  84 VGTKLYIFGGRDEKRE-FSDFYSYDTVKNEWTFLTKLDEeggpeARTFHSMASDENHVYVFGGVSKGGLMKTPerfrtiE 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45593142  529 VYSITDNKWA----PFEAFpQERSSLSLVSLVGTLYAIGGFATLETESGElVPTELNDIWRYNEEEKKWEGV 596
Cdd:PLN02153 163 AYNIADGKWVqlpdPGENF-EKRGGAGFAVVQGKIWVVYGFATSILPGGK-SDYESNAVQFFDPASGKWTEV 232
BACK_KLHL21 cd18460
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a ...
 128-225 3.99e-10

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively.


Pssm-ID: 350535 [Multi-domain]  Cd Length: 101  Bit Score: 57.12  E-value: 3.99e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 128 LCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGda 207
Cdd:cd18460   1 LDVSNCLEMQDFAEAFACRGLAEAAKRFILRHIVELAKGEQFERLPLKRLLEYLSDDGLCVDKEETAYQIALRWVKAD-- 78

                        90
                ....*....|....*...
gi 45593142 208 eaQAERQRALPTVFESVR 225
Cdd:cd18460  79 --PKHRQHFWPELLQHVR 94
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 19-132 4.10e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 57.55  E-value: 4.10e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  19 LQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPE--RAGELHLEEVSPDVVAQVLHYLYTSEIAL 96
Cdd:cd18345   5 LSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEerKQNRVEITDVDHEVMREMLRFIYTGKAPN 84

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45593142  97 DEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSN 132
Cdd:cd18345  85 LDKMADDLLAAADKYALERLKVMCEEALCSNLSVEN 120
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 21-120 4.95e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 56.84  E-value: 4.95e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  21 DGLKDMLDHGKFLDCVVRAGERE-FPCHRLVLAACSPYFRARFLAEPErageLHLEE-VSPDVVAQVLHYLYTSEIALDE 98
Cdd:cd18299   1 EDLRNLLHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLFLMMTV----VTLDSdITPEAFRRVLEFLYTGVLDENE 76

                        90       100
                ....*....|....*....|..
gi 45593142  99 ASVQDLFAAAHRFQIPSIFTIC 120
Cdd:cd18299  77 DDLKELKDAAELLELFDLVMMC 98
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-132 5.48e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 57.28  E-value: 5.48e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  42 REFPCHRLVLAACSPYFRARF---LAEPeRAGELHLEEVSPDVVAQVLHYLYT---SEIALDEASVQDLFAAAHRFQIPS 115
Cdd:cd18297  22 RPFYAHKIVLVTASDRFKSMLssgSTEA-QTPVIEIPDIRYDIFQLMMQYLYTggvESLDVAQDDALELLRAASFFQLDG 100

                        90
                ....*....|....*..
gi 45593142 116 IFTICVSFLQKRLCLSN 132
Cdd:cd18297 101 LKRHCEILLSQQIDLDN 117
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-132 6.24e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 57.27  E-value: 6.24e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  18 LLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPER--AGELHLEEVSPDVVAQVLHYLYTSEIA 95
Cdd:cd18344   9 MLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAMFEHEMEErlKNPIEIHDLDPQVFKEMMGFIYTGKAP 88

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 45593142  96 -LDEASVQ-DLFAAAHRFQIPSIFTICVSFLQKRLCLSN 132
Cdd:cd18344  89 hLHSHSMAcDVLAAADKYGLEGLKVLCEDALCRNLSVEN 127
BTB1_POZ_IBtk cd18301
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 11-92 6.51e-10

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349610 [Multi-domain]  Cd Length: 99  Bit Score: 56.53  E-value: 6.51e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  11 QRLYQQTLLQDGLKDMldhgkfldcVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG------ELHLEEVSPDVVAQ 84
Cdd:cd18301   6 KKLLDEADEGDNIHDV---------VFQVGGKTFPAHKFILASRSDYFRKLFLSSLLTSEdavgcdVVHIEKVPPEIFEQ 76


                ....*...
gi 45593142  85 VLHYLYTS 92
Cdd:cd18301  77 LLQFIYTD 84
PLN02193 PLN02193
nitrile-specifier protein
 399-596 6.92e-10

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 61.51  E-value: 6.92e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  399 PSPRCLFGLGEALNSIYVVGGrEIKDGERCLDSVMCYDRLSFKWGESDP---LPYV-VYGHTVLSHMDLVYVIGGKGSDR 474
Cdd:PLN02193 163 PGLRCSHGIAQVGNKIYSFGG-EFTPNQPIDKHLYVFDLETRTWSISPAtgdVPHLsCLGVRMVSIGSTLYVFGGRDASR 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  475 KcLNKMCVYDPKKFEWKELAPMQ---TARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKW----APFEAFpQER 547
Cdd:PLN02193 242 Q-YNGFYSFDTTTNEWKLLTPVEegpTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKWfhcsTPGDSF-SIR 319

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 45593142  548 SSLSLVSLVGTLYAIGGFATletesgelvpTELNDIWRYNEEEKKWEGV 596
Cdd:PLN02193 320 GGAGLEVVQGKVWVVYGFNG----------CEVDDVHYYDPVQDKWTQV 358
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 26-129 9.53e-10

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 56.50  E-value: 9.53e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  26 MLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFL---AEPErAGELHLEEVSPDVVAQVLHYLY--TSEIaLDEAS 100
Cdd:cd18286  11 LFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLSgswAESN-SSEITLTGVSHAAVSFVLLFIYggVLDL-PDDVN 88

                        90       100
                ....*....|....*....|....*....
gi 45593142 101 VQDLFAAAHRFQIPSIFTICVSFLQKRLC 129
Cdd:cd18286  89 LGELLSLADMYGLDGLKDVVAYTLRRDYC 117
BTB_POZ_ZBTB18_2-like cd18325
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-129 1.15e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349634 [Multi-domain]  Cd Length: 128  Bit Score: 56.58  E-value: 1.15e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  29 HGKFL-DCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEE--VSPDVVAQVLHYLYTSEIALDEASVQDLF 105
Cdd:cd18325  19 HQGFLcDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSdiVTAPAFSLLLEFMYEGKLEFSSLPVEDVL 98

                        90       100
                ....*....|....*....|....*
gi 45593142 106 AAAHRFQIPSIFTICVSFLQ-KRLC 129
Cdd:cd18325  99 AAASYLHMYDIVKVCKGKLKdKELC 123
BACK_KLHL23 cd18462
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is ...
 132-203 1.76e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 23 (KLHL23); KLHL23 is involved in tumorigenesis and resistance to anticancer drug treatment. It also associates with cone-rod dystrophy.


Pssm-ID: 350537 [Multi-domain]  Cd Length: 102  Bit Score: 55.12  E-value: 1.76e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45593142 132 NCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAG 203
Cdd:cd18462   5 NCLGMHSFAEFHVCPELEKESRRIILSRFEEVWQQEEFLELSKEKLLYILSRENLNVWKEEVLIEAVVKWVA 76
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 35-111 2.19e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 54.21  E-value: 2.19e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  35 CVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAgELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRF 111
Cdd:cd01165   1 VVLVVEGEKFHVNKELLAQSSEYFRALFrggFRESGQA-EINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 28-129 2.47e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 55.38  E-value: 2.47e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  28 DHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARF---LAEPERAGE----LHLEEVSPDVVAQVLHYLYTSEIALDEAS 100
Cdd:cd18296  13 QELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLrdhFAESEENNGsipvVTLHDVSPEVFAIVLYYIYTDDTDLPPEN 92

                        90       100
                ....*....|....*....|....*....
gi 45593142 101 VQDLFAAAHRFQIPSIFTICVSFLQKRLC 129
Cdd:cd18296  93 AYDVLYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_ZBTB18_RP58 cd18324
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-127 3.78e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349633 [Multi-domain]  Cd Length: 147  Bit Score: 55.81  E-value: 3.78e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  29 HGKFL-DCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEE--VSPDVVAQVLHYLYTSEIALDEASVQDLF 105
Cdd:cd18324  19 HQGFLcDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSdiVTAPAFALLLEFMYEGKLQFKDLPIEDVL 98

                        90       100
                ....*....|....*....|..
gi 45593142 106 AAAHRFQIPSIFTICVSFLQKR 127
Cdd:cd18324  99 AAASYLHMYDIVKVCKKKLKEK 120
BTB_POZ_BTBD1 cd18346
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-132 5.11e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 1 (BTBD1); BTBD1, also called Hepatitis C virus NS5A-transactivated protein 8 or HCV NS5A-transactivated protein 8, is a BTB-domain-containing Kelch-like protein that is expressed in skeletal muscle and interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. BTBD1 may serve as substrate-specific adaptor of an E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349655 [Multi-domain]  Cd Length: 133  Bit Score: 55.06  E-value: 5.11e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  40 GEREFPCHRLVLAACSPYFRARFLA-EPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFT 118
Cdd:cd18346  40 GAQRIPAHRFVLAAGSAVFDAMFNGgMATTSAEIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPALEA 119

                        90
                ....*....|....
gi 45593142 119 ICVSFLQKRLCLSN 132
Cdd:cd18346 120 HCVEFLTKHLRADN 133
PHA02790 PHA02790
Kelch-like protein; Provisional
 50-424 5.35e-09

Kelch-like protein; Provisional


Pssm-ID: 165153 [Multi-domain]  Cd Length: 480  Bit Score: 58.90  E-value: 5.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   50 VLAACSPYFRARfLAEPERAGELHLEEVSPDV----VAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQ 125
Cdd:PHA02790  39 ILKKLSPYFRTH-LRQKYTKNKDPVTRVCLDLdihsLTSIVIYSYTGKVYIDSHNVVNLLRASILTSVEFIIYTCINFIL 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  126 KRLCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDA----DFLGLSadeliAIISSDGLNVEKEEAVFEAVMRW 201
Cdd:PHA02790 118 RDFRKEYCVECYMMGIEYGLSNLLCHTKDFIAKHFLELEDDIidnfDYLSMK-----LILESDELNVPDEDYVVDFVIKW 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  202 agsgdaeAQAERQR---ALPTVFESVRCRLL-PRAF-----------------LESRVERHPLVR---AQPELLRKVQMV 257
Cdd:PHA02790 193 -------YMKRRNRlgnLLLLIKNVIRSNYLsPRGInnvkwildctkifhcdkQPRKSYKYPFIEypmNMDQIIDIFHMC 265

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  258 KDAHEGRITTLrkkkkgkdgagakeadkgtskakaeedeeaeriLPGILNDTLrfgmflqdlifmisEEGAVAYDPAANE 337
Cdd:PHA02790 266 TSTHVGEVVYL---------------------------------IGGWMNNEI--------------HNNAIAVNYISNN 298

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  338 CYCASLSNQvPKNHVSLVTKENQVFVAGGLfynednkedPMSAYFLQFDHLDSEWLGMPPLPSPRCLFGLGEALNSIYVV 417
Cdd:PHA02790 299 WIPIPPMNS-PRLYASGVPANNKLYVVGGL---------PNPTSVERWFHGDAAWVNMPSLLKPRCNPAVASINNVIYVI 368


                 ....*..
gi 45593142  418 GGREIKD 424
Cdd:PHA02790 369 GGHSETD 375
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-132 6.86e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 54.36  E-value: 6.86e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  40 GEREFPCHRLVLAACSPYFRARF---LAEPERagELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSI 116
Cdd:cd18281  34 NEQRIPAHKFVLSIGSAVFDAMFnggMATTSA--EIELPDVEPAAFLALLRFLYSDEVQIGPETVMTTLYTAKKYAVPAL 111

                        90
                ....*....|....*.
gi 45593142 117 FTICVSFLQKRLCLSN 132
Cdd:cd18281 112 ESACVEFLKKNLSSDN 127
BACK_KLHL37_ENC1 cd18515
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also ...
 131-230 8.23e-09

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 37 (KLHL37); KLHL37, also called ectoderm-neural cortex protein 1 (ENC-1), or nuclear matrix protein NRP/B, or p53-induced gene 10 protein, is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells.


Pssm-ID: 350590 [Multi-domain]  Cd Length: 98  Bit Score: 53.44  E-value: 8.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 131 SNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAgSGDAEaq 210
Cdd:cd18515   3 TNCLGMLLLSDAHQCTKLYELSWRMCLSNFQTICKTEDFLQLPKDMVVQLLSSEELETEDERLVYEAAINWV-NYDLK-- 79

                        90       100
                ....*....|....*....|
gi 45593142 211 aERQRALPTVFESVRCRLLP 230
Cdd:cd18515  80 -KRHCYLSELLQTVRLALLP 98
Kelch smart00612
Kelch domain;
463-510 9.23e-09

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 51.41  E-value: 9.23e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 45593142    463 LVYVIGGkGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDG 510
Cdd:smart00612   1 KIYVVGG-FDGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB42 cd18956
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-127 1.05e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349737 [Multi-domain]  Cd Length: 129  Bit Score: 54.05  E-value: 1.05e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEP---ERAGELHLEEVSPDVVAQVLHYLYTSEIALDEA 99
Cdd:cd18956  14 LRQQRELGFLCDCTVLVGDARFPAHRAVLAACSVYFHLFYRDRPaggRDTVRLNGDIVTAPAFGRLLDFMYEGRLDLRSL 93

                        90       100
                ....*....|....*....|....*...
gi 45593142 100 SVQDLFAAAHRFQIPSIFTICVSFLQKR 127
Cdd:cd18956  94 PVEDVLAAASYLHMYDIVKVCKGRLREK 121
BTB_POZ_ZBTB32_FAZF_TZFP cd18218
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-120 1.27e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349527 [Multi-domain]  Cd Length: 110  Bit Score: 53.02  E-value: 1.27e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRaRFLAEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAH 109
Cdd:cd18218  16 GALCDTLITVGSQEFPAHSLVLAGASQQLG-RQLTNPNPGQWCLGEGISPSTFKQLLDFVYGESVEVQPGELRPLLEAAR 94

                        90
                ....*....|.
gi 45593142 110 RFQIPSIFTIC 120
Cdd:cd18218  95 ALEVESLEEAC 105
BTB_POZ_ZBTB38_CIBZ cd18223
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-114 2.84e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 38 (ZBTB38); ZBTB38, also termed CIBZ, is a transcriptional regulator with bimodal DNA-binding specificity. It binds with a higher affinity to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3', as well as E-box elements (5'-CACGTG-3'). It can also bind specifically to a single methyl-CpG pair. ZBTB38 represses transcription in a methyl-CpG-dependent manner. It is a negative regulator of endoplasmic reticulum stress-associated apoptosis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349532 [Multi-domain]  Cd Length: 114  Bit Score: 52.10  E-value: 2.84e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  16 QTLLQDgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFlAEPE---RAGELHLEEVSPDVVAQVLHYLYTS 92
Cdd:cd18223   3 DTVLSC-LNEQRIQGILCDVTIVVEDTKFKAHKNVLAASSLYFKNAF-SSQEiwiSSHVLELPDLKAEVFAEILNFIYSS 80

                        90       100
                ....*....|....*....|...
gi 45593142  93 EIALDEA-SVQDLFAAAHRFQIP 114
Cdd:cd18223  81 KVVVKRQeTVTDLVAAGKKLGIT 103
BTB1_POZ_KLHL33 cd18262
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 8-116 3.91e-08

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349571 [Multi-domain]  Cd Length: 101  Bit Score: 51.44  E-value: 3.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   8 AEEQRLYQQTLLqdglkdmldhgkfLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLeEVSPDVVAQVLH 87
Cdd:cd18262   7 GEAQRLREQRLL-------------LDETVSVGGRSYGVHSVILAAVSSLFRERLLGSNGPLPPLSL-EVTPVGWEAVLT 72

                        90       100
                ....*....|....*....|....*....
gi 45593142  88 YLYTSEIALDEASVQDLFAAAHRFQIPSI 116
Cdd:cd18262  73 FAYTGVLGRNPATVGDILVAAEALGAPRV 101
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-123 5.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 51.52  E-value: 5.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  16 QTLLQDgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG-----ELHLEEVSPDVVAQVLHYLY 90
Cdd:cd18292   2 REFLQD-IAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWWSESkqseiELVEDPECAAVFEKFLRYLY 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 45593142  91 TSEIALDEASVQDLFAAAHRFQIPSIFTICVSF 123
Cdd:cd18292  81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDF 113
BTB_POZ_ZBTB14 cd18204
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-127 7.24e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 14 (ZBTB14); ZBTB14 is also called zinc finger protein 161 (Zfp-161), zinc finger protein 478, zinc finger protein 5 (ZF5), or Zfp-5. It is a novel transcriptional activator of the dopamine transporter, binding it's promoter at the consensus sequence 5'-CCTGCACAGTTCACGGA-3'. It also binds to 5'-d(GCC)(n)-3' trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. ZBTB14 acts as a transcriptional repressor of MYC and thymidine kinase promoters. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349513 [Multi-domain]  Cd Length: 114  Bit Score: 51.19  E-value: 7.24e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  15 QQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLA-EPERAGELHLEEVSPDVVAQVLHYLYTSE 93
Cdd:cd18204   1 HKTVFLKTLNEQRLEGEFCDIAIVVEDVKFRAHRCVLAACSTYFKKLFKKlEVDSSSVIEIDFLRSDIFEEVLNYMYTAK 80

                        90       100       110
                ....*....|....*....|....*....|....
gi 45593142  94 IALDEASVQDLFAAAHRFQIPSIFTICVsflQKR 127
Cdd:cd18204  81 ISVKKEDVNLMMSSGQILGIRFLDKLCS---QKR 111
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 39-132 1.15e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 51.17  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  39 AGEREFPCHRLVLAACSPYFRARFLAE-PERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIF 117
Cdd:cd18348  32 GGTQRLPGHKYVLAVGSSVFHAMFYGElAEDKDEIRIPDVEPAAFLAMLKYIYCDEIDLAADTVLATLYAAKKYIVPHLA 111

                        90
                ....*....|....*
gi 45593142 118 TICVSFLQKRLCLSN 132
Cdd:cd18348 112 RACVNFLETSLSAKN 126
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-125 1.23e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 50.81  E-value: 1.23e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  29 HGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFlaepeRAGELHLEEVS----PDVVAQVLHYLYTSEIALDEASVQDL 104
Cdd:cd18222  22 QGRLCDIVVNVQGQSFRAHKVVLAASSPYFRDHM-----SLNEMSTVSISviknPTVFEQLLSFCYTGRICLQLADIISY 96

                        90       100
                ....*....|....*....|.
gi 45593142 105 FAAAHRFQIPSIFTICVSFLQ 125
Cdd:cd18222  97 LTAASFLQMQHIIDKCTQILE 117
BTB_POZ_ZBTB8A_BOZF1 cd18329
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-124 1.41e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349638 [Multi-domain]  Cd Length: 116  Bit Score: 50.21  E-value: 1.41e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   5 LEQAEEQRlyQQTLlqdglkdmldhgkFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE---LHLEEVSPDV 81
Cdd:cd18329   9 LQQLDEQR--KQEL-------------FCDCSILVEGQVFKAHRNVLFASSGYFKMLLSQNAKETGQptvATFDVFSPDT 73

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 45593142  82 VAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFL 124
Cdd:cd18329  74 FTIILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116
BTB_POZ_ZBTB21_ZNF295 cd18209
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-104 1.85e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 21 (ZBTB21); ZBTB21, also called zinc finger protein 295 (ZNF295), is a transcription repressor that acts in a selective manner on different promoters. It may be involved in the bi-directional control of gene expression in concert with another transcription factor ZFP161. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349518 [Multi-domain]  Cd Length: 112  Bit Score: 49.87  E-value: 1.85e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARFL-AEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDE---ASVQDL 104
Cdd:cd18209  16 GQLCDVLLIVGDQKFRAHKNVLAASSEYFQSLFTeKENESQSVFQLDFCEPDAFENVLNYIYSSSLFVEKsslAAVQEL 94
BTB_POZ_ZBTB12 cd18203
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-120 1.97e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 12 (ZBTB12); ZBTB12, also called protein G10, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349512 [Multi-domain]  Cd Length: 122  Bit Score: 49.88  E-value: 1.97e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  31 KFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEEvSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHR 110
Cdd:cd18203  24 RFCDVTIVADSLKFRGHKVVLAACSPFLRDQFLLNPSSELQVSLMH-SSRVVADLLLSCYTGALEFSVRDIVNYLTAASY 102

                        90
                ....*....|
gi 45593142 111 FQIPSIFTIC 120
Cdd:cd18203 103 LQMEHVVEKC 112
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-136 2.17e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 49.41  E-value: 2.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  34 DCVVRAGEREFPCHRLVLAACSPYFRARFLAEPerageLHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQI 113
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRARLSRDI-----LKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQM 80

                        90       100
                ....*....|....*....|...
gi 45593142 114 PSIFTICVSFLQKRLCLSNCLAV 136
Cdd:cd18275  81 PCAAQCAVDAVRAQLCLGNCYEV 103
BTB_POZ_ZBTB25_ZNF46_KUP cd18213
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-91 2.35e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25); ZBTB25, also called zinc finger protein 46 (ZNF46) or zinc finger protein KUP, is a transcription repressor that facilitates viral RNA transcription and replication. It interacts with viral RNA-dependent RNA polymerase (RdRp) proteins and modulates their transcription activity. It also functions as a viral RNA-binding protein, binding preferentially to the U-rich sequence within 5' UTR of vRNA. ZBTB25 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349522 [Multi-domain]  Cd Length: 128  Bit Score: 49.89  E-value: 2.35e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45593142  14 YQQTLLQDgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEEVSPDVVAQVLHYLYT 91
Cdd:cd18213   4 HSLVLLQQ-LNMQREFGFLCDCTVAIGDVYFKAHRAVLAAFSNYFKMIFIHQSSECIKIQPTDIQPDIFSYLLHIMYT 80
BTB_POZ_BACH2 cd18278
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 22-124 2.57e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349587 [Multi-domain]  Cd Length: 124  Bit Score: 49.95  E-value: 2.57e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  22 GLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHL-EEVSPDVVAQVLHYLYTSEIALDEAS 100
Cdd:cd18278  21 CLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLpEEVTARGFGPLLQFAYTAKLLLSREN 100

                        90       100
                ....*....|....*....|....
gi 45593142 101 VQDLFAAAHRFQIPSIFTICVSFL 124
Cdd:cd18278 101 IQEVIRCAEFLRMHNLEDSCFRFL 124
BTB_POZ_ZBTB33_KAISO cd18219
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-94 2.62e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kaiso; Kaiso, also called zinc finger and BTB domain-containing protein 33 (ZBTB33), is a DNA methylation-dependent transcriptional repressor that binds to methylated CpG dinucleotides in the consensus sequence 5'-CGCG-3'. It also binds to the non-methylated consensus sequence 5'-CTGCNA-3', also known as the consensus kaiso binding site (KBS). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349528 [Multi-domain]  Cd Length: 106  Bit Score: 49.06  E-value: 2.62e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLQDgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAeperAGE-LHLEEVSPDVVAQVLHYLYTS 92
Cdd:cd18219   4 YSGSLLKS-LNEQRGHGLFCDVTVIVEDRKFRAHKNILSASSTYFHQLFSV----AGQvVELNFIRADIFAEILNYIYSS 78


                ..
gi 45593142  93 EI 94
Cdd:cd18219  79 KI 80
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 24-128 3.03e-07

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 49.16  E-value: 3.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  24 KDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAE--PERAGELHLEEVSPDVVAQVLHYLYTSEIA-LDEAS 100
Cdd:cd18300   1 KLFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFGGNfrESSAKEVELPGVSKETFLALLEYLYTDQAPiLEDGD 80

                        90       100
                ....*....|....*....|....*...
gi 45593142 101 VQDLFAAAHRFQIPSIFTICVSFLQKRL 128
Cdd:cd18300  81 CVGLIVLANRLCLPRLVALCEQYIVKEL 108
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 13-108 3.29e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 49.03  E-value: 3.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  13 LYQQTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPErAGELHLEEVSPDVVAQVLHYLYTS 92
Cdd:cd18226   3 QYNKNLLKYLNDDRQKQSSFCDLVITVEGKEFSAHKVVVAVGSSYFHACLSKNPN-TDAVTLDHVSYSVFQHLLEFLYTS 81

                        90
                ....*....|....*.
gi 45593142  93 EIALDEASVQDLFAAA 108
Cdd:cd18226  82 EFFVYENEIPLVLEAA 97
BTB_POZ_BTBD2 cd18347
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 40-132 3.56e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349656 [Multi-domain]  Cd Length: 127  Bit Score: 49.30  E-value: 3.56e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  40 GEREFPCHRLVLAACSPYFRARFLA-EPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFT 118
Cdd:cd18347  34 GSQRIPAHRFVLAVGSAVFDAMFNGgMATTSTEIELPDVEPAAFLALLKFLYSDEVQIGPETVMTTLYTAKKYAVPALEA 113

                        90
                ....*....|....
gi 45593142 119 ICVSFLQKRLCLSN 132
Cdd:cd18347 114 HCVEFLKKNLRADN 127
BTB_POZ_ZBTB8B cd18330
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 32-124 5.69e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8B (ZBTB8B); ZBTB8B may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349639 [Multi-domain]  Cd Length: 113  Bit Score: 48.38  E-value: 5.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  32 FLDCVVRAGEREFPCHRLVLAACSPYFRA---RFLAEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAA 108
Cdd:cd18330  18 FCDCSIIVEGRIFKAHRNILFANSGYFRAlliHYIQDSGRHSTASLDIVTSEAFSIILDFLYSGKLDLCSENVIEVMSAA 97

                        90
                ....*....|....*.
gi 45593142 109 HRFQIPSIFTICVSFL 124
Cdd:cd18330  98 SYLQMTDVVNFCKGYI 113
BTB_POZ_ZBTB29-like cd18216
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-126 5.85e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer proteins, Hic-1 and Hic-2; The family includes hypermethylated in cancer proteins, Hic-1 and Hic-2. Hic-1 is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. Hic-2 is a homolog of tumor suppressor Hic-1 that functions as a transcriptional regulator. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349525 [Multi-domain]  Cd Length: 118  Bit Score: 48.68  E-value: 5.85e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  16 QTLLQdgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEperaGELHLEE--VSPDVVAQVLHYLYTSE 93
Cdd:cd18216   6 QLLLQ--LNNQRTKGFLCDVIIVVENSLFRAHKNVLAASSGYFKSLVLHD----NLIHLDQdmVSPTVFQQILDFIYTGK 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45593142  94 IA---LDEASVQDLFAAAHRFQIPSIFTICVSFLQK 126
Cdd:cd18216  80 LLdslFEEPNLSEVLAAANYLQLPDLAALCRSKLKR 115
BTB_POZ_ZBTB8 cd18199
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-124 6.52e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349508 [Multi-domain]  Cd Length: 113  Bit Score: 48.19  E-value: 6.52e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLQDgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRA---RFLAEPERAGELHLEEVSPDVVAQVLHYLY 90
Cdd:cd18199   1 HQSRLLGQ-LNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMllsHYIQDTGRPSTASFDVFSSDAFSIILDFVY 79

                        90       100       110
                ....*....|....*....|....*....|....
gi 45593142  91 TSEIALDEASVQDLFAAAHRFQIPSIFTICVSFL 124
Cdd:cd18199  80 SGKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113
BTB_POZ_ZBTB1 cd18192
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-113 7.83e-07

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349501 [Multi-domain]  Cd Length: 114  Bit Score: 48.28  E-value: 7.83e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLE--EVSPDVVAQVLHYLYTSEIALDEASVQDLFAA 107
Cdd:cd18192  19 GFLCDCCIAIDDIYFQAHKAVLAACSSYFRMMFINHQHTTAQLNLSnmKISAECFDLILQFMYLGKIMTAPSDFEQLKVA 98


                ....*.
gi 45593142 108 AHRFQI 113
Cdd:cd18192  99 MNYLQL 104
BTB_POZ_BACH1 cd18277
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-124 1.01e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1); BACH1, also called BTB-basic leucine zipper transcription factor 1, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. It can act as repressor or activator. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. It is also a negative regulator of nuclear factor erythroid 2-related factor 2 (Nrf2) that controls antioxidant response elements (ARE)-dependent gene expressions. BACH1 binds to NF-E2 binding sites in vitro, and plays important roles in coordinating transcription activation and repression by MafK. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349586 [Multi-domain]  Cd Length: 120  Bit Score: 48.14  E-value: 1.01e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPEraGELHL---EEVSPDVVAQVLHYLYTSEIALDEA 99
Cdd:cd18277  18 LNDQRKKDVLCDVTILVEGQRFRAHRSVLAACSSYFHSRIVGQAD--AELNItlpEEVTVKGFEPLIQFAYTAKLILSKD 95

                        90       100
                ....*....|....*....|....*
gi 45593142 100 SVQDLFAAAHRFQIPSIFTICVSFL 124
Cdd:cd18277  96 NVDEVCKCVEFLSVHNIEESCFQFL 120
BACK_KLHL11 cd18451
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a ...
 128-208 1.04e-06

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 11 (KLHL11); KLHL11 is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation.


Pssm-ID: 350526 [Multi-domain]  Cd Length: 88  Bit Score: 46.88  E-value: 1.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 128 LCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSGDA 207
Cdd:cd18451   1 LNLSNCVAIHSLAHMYSLDQLALKAADMIRRNFHKVIQDEEFYTLPFHLVRDWLSDAEITVDSEEVLFEAVLKWVQRNAE 80


                .
gi 45593142 208 E 208
Cdd:cd18451  81 E 81
BTB_POZ_ZBTB46 cd18230
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-131 1.16e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349539 [Multi-domain]  Cd Length: 125  Bit Score: 48.13  E-value: 1.16e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQtLLQDgLKDMLDHGKFLD-CVVRAGeREFPCHRLVLAACSPYFRARFL---AEPERAGELHLEEVSPDVVAQVLHYL 89
Cdd:cd18230   5 YRH-LLRE-LNEQRQHGILCDvCIIVEG-KIFKAHKNVLLGSSRYFKTLYCqvqKTSDQATVTHLDIVTAQGFKAIIDFM 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45593142  90 YTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLS 131
Cdd:cd18230  82 YSAHLALTSKNVIEVMSAASYLQMTDIVQACHNFIKAALDIS 123
BTB_POZ_ZBTB28_BCL6B cd18332
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-125 1.35e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell CLL/lymphoma 6 member B protein (BCL6B); BCL6B is also called Bcl6-associated zinc finger protein, zinc finger protein 62, or zinc finger and BTB domain-containing protein 28 (ZBTB28). It is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. BCL6B plays an important role as a potential tumor suppressor in gastric cancer; it is found preferentially methylated in gastric cancer. It also inhibits both colorectal cancer growth and hepatocellular carcinoma metastases. BCL6B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349641 [Multi-domain]  Cd Length: 114  Bit Score: 47.54  E-value: 1.35e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  34 DCVVRAGEREFPCHRLVLAACSPYFRARFLaepERAGE----LHLEE-VSPDVVAQVLHYLYTSEIALDEASVQDLFAAA 108
Cdd:cd18332  21 DVTLLVGGTPLRAHKAVLIACSGFFYSIFS---GRVGEgvsvLTLPSgLEARGFQLLLDFMYTSRLPLTPRTVPAVLAAA 97

                        90
                ....*....|....*..
gi 45593142 109 HRFQIPSIFTICVSFLQ 125
Cdd:cd18332  98 TYLQMEHVVETCRRFIQ 114
BTB1_POZ_BTBD7 cd18283
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 44-104 1.38e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the first domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349592 [Multi-domain]  Cd Length: 92  Bit Score: 46.56  E-value: 1.38e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45593142  44 FPCHRLVLAACSPYFRARFLAEPERAGELHLEEVSPDV----VAQVLHYLYTSEIALDEASVQDL 104
Cdd:cd18283  14 FPVHRAILSARCPFFRDLLSSSPGYGAEIPVDLPTAGIdvpmFSALLRYLYTGEFGSEDSRSQNL 78
BTB2_POZ_KLHL33 cd18263
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 34-135 1.43e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 33 (KLHL33); KLHL33 contains BTB domains and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. KLHL33 gene expression in normal and tumor tissue suggest a significant association with prostate cancer risk. KLHL33 contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349572 [Multi-domain]  Cd Length: 118  Bit Score: 47.50  E-value: 1.43e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  34 DCVVRAGEREFPCHRLVLAACSPYFRARFLA--EPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRF 111
Cdd:cd18263  15 DVQLEADGSIFRVHRVILAAGSDYFRAMFTSgmKESTQSVVQLPTIPAKDLRLLISFAYSGILHLSWENLFEATCTALQL 94

                        90       100
                ....*....|....*....|....
gi 45593142 112 QIPSIFTICVSFLQKRLCLSNCLA 135
Cdd:cd18263  95 QISGALALCLDFLQREISPARCLD 118
BTB_POZ_ZBTB34 cd18220
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-125 1.46e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 34 (ZBTB34); ZBTB34 acts as a transcriptional regulator. It downregulates specificity protein (Sp) transcription factors Sp1, Sp3, and Sp4 in pancreatic cancer cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349529 [Multi-domain]  Cd Length: 120  Bit Score: 47.71  E-value: 1.46e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLQDgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEEvSPDVVAQVLHYLYTSE 93
Cdd:cd18220   8 YSNTVLSQ-LNELRLQGKLCDIIVHIQGQPFRAHKAVLAASSPYFRDHSALSTMSGLSISVIK-NPNVFEQLLSFCYTGR 85

                        90       100       110
                ....*....|....*....|....*....|..
gi 45593142  94 IALDEASVQDLFAAAHRFQIPSIFTICVSFLQ 125
Cdd:cd18220  86 MSLQLKDVVSFLTAASFLQMQCVIDKCTQILE 117
Kelch_6 pfam13964
Kelch motif;
454-500 1.91e-06

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 45.02  E-value: 1.91e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 45593142   454 GHTVLSHMDLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTAR 500
Cdd:pfam13964   4 FHSVVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 18-104 2.11e-06

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 46.86  E-value: 2.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  18 LLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEE--VSPDVVAQVLHYLYTS--E 93
Cdd:cd18295   5 YYDEFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETKWKDKREINLKHplVNPDAFRALLQYLYTGrlE 84

                        90
                ....*....|.
gi 45593142  94 IALDEasVQDL 104
Cdd:cd18295  85 IHVDD--VEDC 93
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 28-132 2.47e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 46.59  E-value: 2.47e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  28 DHGKFLDCVVRAGE-REFPCHRLVLAACSPYFRARFLAE-PERAGELHLE-EVSPDVVAQVLHYLYTSEIA-----LDEA 99
Cdd:cd18302   1 KHSDLYDVTIVSEDgKEFPCHKCVLVARLEYFHSMLSSSwIEASSCSALTmPIPSDILEIILDYLYTDEASavkesQNVE 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 45593142 100 SVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSN 132
Cdd:cd18302  81 FLCNVLVIADQLLITRLKEICEVALVELLSLKN 113
BTB_POZ_ZBTB2 cd18193
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 18-95 2.77e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349502 [Multi-domain]  Cd Length: 115  Bit Score: 46.52  E-value: 2.77e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45593142  18 LLQDgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEEVSPDVVAQVLHYLYTSEIA 95
Cdd:cd18193   8 LLQQ-LNAQREFGFLCDCTVAIGDVYFKAHKSVLASFSNYFKMLFVHQTSECVRLKPTDIQPDIFSYLLHLMYTGKMA 84
BACK_calicin cd18503
BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal ...
 128-201 3.15e-06

BACK (BTB and C-terminal Kelch) domain found in calicin; Calicin is a basic cytoskeletal protein involved in the formation and maintenance of the highly regular organization of the postacrosomal perinuclear theca, the calyx of mammalian spermatozoa.


Pssm-ID: 350578 [Multi-domain]  Cd Length: 78  Bit Score: 45.42  E-value: 3.15e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45593142 128 LCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRW 201
Cdd:cd18503   1 LDRDNCLTALCLATTAGLKDLSDEIYDYIRDNFFDVSGTREFLQCPYDIFSRLLKDENLHVNNEDQVLLALLNW 74
BTB_POZ_BACH cd18955
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-124 3.44e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349736 [Multi-domain]  Cd Length: 94  Bit Score: 45.54  E-value: 3.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  34 DCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHL-EEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQ 112
Cdd:cd18955   3 DVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGDLVITLpEEVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEFLG 82

                        90
                ....*....|..
gi 45593142 113 IPSIFTICVSFL 124
Cdd:cd18955  83 VHNIEKACFDFL 94
BTB_POZ_CP190-like cd18311
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 43-113 3.51e-06

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster centrosomal protein 190kD (CP190) and similar proteins; CP190 is a large, multi-domain protein, first identified as a centrosome protein with oscillatory localization over the course of the cell cycle. It has an essential function in the nucleus as a chromatin insulator. It is known to associate with the nuclear matrix, components of the RNAi machinery, active promoters and borders of the repressive chromatin domains. CP190 contains an N-terminal BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349620 [Multi-domain]  Cd Length: 110  Bit Score: 46.04  E-value: 3.51e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 45593142  43 EFPCHRLVLAACSPYFRARFLAEPERAGELHL-EEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQI 113
Cdd:cd18311  26 QLKVHRLVLSACTDYFNVLEQTCEIVDDTLIMpNELQADAVVPVINFMYTGQLEFEEKSYGKLLRTAKELNM 97
Kelch_3 pfam13415
Galactose oxidase, central domain;
462-508 4.60e-06

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 43.82  E-value: 4.60e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 45593142   462 DLVYVIGGKGSDR-KCLNKMCVYDPKKFEWKELAPMQTARSLFGATVH 508
Cdd:pfam13415   2 DKLYIFGGLGFDGqTRLNDLYVYDLDTNTWTQIGDLPPPRSGHSATYI 49
BACK_BTBD17 cd18493
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); ...
 148-201 4.78e-06

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.


Pssm-ID: 350568  Cd Length: 74  Bit Score: 44.49  E-value: 4.78e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 45593142 148 LAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRW 201
Cdd:cd18493  20 LAEACLEFIAWNFEKVLKSPDWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKW 73
BTB_POZ_ZBTB29_HIC1 cd18333
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-126 5.99e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349642 [Multi-domain]  Cd Length: 121  Bit Score: 45.66  E-value: 5.99e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  15 QQTLLQdgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRArfLAEPERAGELHLEEVSPDVVAQVLHYLYTSEI 94
Cdd:cd18333   6 RQLLLQ--LNTQRTKGFLCDVIIVVQNALFRAHKNILAASSVYLKS--LVVHDNLINLDHEMVSPGIFRLILDYIYTGRL 81

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45593142  95 A-LDEASVQDL---FAAAHRFQIPSIFTICVSFLQK 126
Cdd:cd18333  82 SeGDPGSEQNLgavLAAASYLQIPDLVALCKKKLKR 117
BTB_POZ_ZBTB23_GZF1 cd18211
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-120 6.44e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in glial cell line-derived neurotrophic factor-inducible zinc finger protein 1 (GZF1); GZF1 is also called GDNF-inducible zinc finger protein 1, zinc finger and BTB domain-containing protein 23 (ZBTB23), or zinc finger protein 336 (ZNF336). It is a sequence-specific transcriptional repressor that binds the GZF1 responsive element (GRE), with the consensus sequence of 5'-TGCGCN[TG][CA]TATA-3'. It may play a role in renal branching morphogenesis. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349520 [Multi-domain]  Cd Length: 128  Bit Score: 46.00  E-value: 6.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVR----AGEREFPCHRLVLAACSPYFRARFLAEPERAGE---LHLEEVSPDVVAQVLHYLYTSEIALDEASVQ 102
Cdd:cd18211  23 GHLCDVTVQvehqGSKEEFSAHKAVLAASSKYFKEVFLNEKISDGKntnVMLNEIYTADFASFLEFVYTAKVEVEEDRVQ 102

                        90
                ....*....|....*...
gi 45593142 103 DLFAAAHRFQIPSIFTIC 120
Cdd:cd18211 103 RMLEIAEKLKCLDLSETC 120
BTB_POZ_ZBTB39 cd18224
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-122 7.51e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 39 (ZBTB39); ZBTB39 may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349533 [Multi-domain]  Cd Length: 123  Bit Score: 45.59  E-value: 7.51e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  34 DCVVRAGEREFPCHRLVLAACSPYFRARFL-AEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQ 112
Cdd:cd18224  28 DVTIVVGNRSFAAHKAVLACAAGYFQKLFLsTELDVARTYVVDFITPANFEKVLSFIYTSELFTDLINVGVIYEVAEKLG 107

                        90
                ....*....|
gi 45593142 113 IPSIFTICVS 122
Cdd:cd18224 108 MEDLLKACHS 117
PHA02713 PHA02713
hypothetical protein; Provisional
 23-520 9.27e-06

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 48.47  E-value: 9.27e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   23 LKDMLDHGKFLDCVVRAGE-REFPCHRLVLAACSPYFRARFlAEPERAGEL----HLEEVSPDVVAQVLHYLYTSEIAld 97
Cdd:PHA02713  16 ISNLLDDDILCDVIITIGDgEEIKAHKTILAAGSKYFRTLF-TTPMIIRDLvtrvNLQMFDKDAVKNIVQYLYNRHIS-- 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   98 EASVQDLFAAAHRFQIPSIFTICVSFLQKRLCLSNCLAVF-RLGLLLDCARLAVAARDFICAHFTLVARDAdFLGLSADE 176
Cdd:PHA02713  93 SMNVIDVLKCADYLLIDDLVTDCESYIKDYTNHDTCIYMYhRLYEMSHIPIVKYIKRMLMSNIPTLITTDA-FKKTVFEI 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  177 LIAIISS-DGLNVEKEEAVFEAVMRWAgsgDAEAQAERQraLPTVFESVRCRLLPRaflESRV--ERHPLVRAQPELlrk 253
Cdd:PHA02713 172 LFDIISTnDNVYLYREGYKVTILLKWL---EYNYITEEQ--LLCILSCIDIQNLDK---KSRLllYSNKTINMYPSC--- 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  254 VQMVKDAHEGRittlrkkkkgkdgagakeadkgtskakaeedeeaeRILPgilndtLRFGMFLQDLIFMISEEGAVAYDP 333
Cdd:PHA02713 241 IQFLLDNKQNR-----------------------------------NIIP------RQLCLVCHDTKYNVCNPCILVYNI 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  334 AANECYCASLSNQVPKNHVSLVTkENQVFVAGGLFYNEDNKEdpmSAYFLQFDHldSEWLGMPPLPSPRCLFGLGEALNS 413
Cdd:PHA02713 280 NTMEYSVISTIPNHIINYASAIV-DNEIIIAGGYNFNNPSLN---KVYKINIEN--KIHVELPPMIKNRCRFSLAVIDDT 353

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  414 IYVVGGREIKDGERcldSVMCYDRLSFKWGESDPLPYVV--YGHTVLSHMdlVYVIGGKGS-----------------DR 474
Cdd:PHA02713 354 IYAIGGQNGTNVER---TIECYTMGDDKWKMLPDMPIALssYGMCVLDQY--IYIIGGRTEhidytsvhhmnsidmeeDT 428

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....*.
gi 45593142  475 KCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTD 520
Cdd:PHA02713 429 HSSNKVIRYDTVNNIWETLPNFWTGTIRPGVVSHKDDIYVVCDIKD 474
BTB_POZ_ZBTB27-like cd18215
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-123 9.85e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349524 [Multi-domain]  Cd Length: 113  Bit Score: 44.86  E-value: 9.85e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  16 QTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGE-LHLE-EVSPDVVAQVLHYLYTSE 93
Cdd:cd18215   3 ASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSvINLDpEIEPEGFRILLDFMYTSR 82

                        90       100       110
                ....*....|....*....|....*....|
gi 45593142  94 IALDEASVQDLFAAAHRFQIPSIFTICVSF 123
Cdd:cd18215  83 LNLREGNIMAVMATAMYLQMEHVVDTCRKF 112
BTB_POZ_ZBTB40 cd18225
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-123 1.36e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349534 [Multi-domain]  Cd Length: 116  Bit Score: 44.43  E-value: 1.36e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLQDgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRArfLAEPERAGELHLEEVSPDVVAQVLHYLYTSE 93
Cdd:cd18225   6 YSRQLLQQ-LHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKS--LLDSTDTISIDASVVSPEEFALLLEMVYTGK 82

                        90       100       110
                ....*....|....*....|....*....|
gi 45593142  94 IALDEASVQDLFAAAHRFQipsIFTICVSF 123
Cdd:cd18225  83 LPPGKHNFTKIISVADSLQ---MFDVAVSC 109
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 453-497 1.45e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 42.60  E-value: 1.45e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 45593142   453 YGHTVLSHMDLVYVIGGKGSDRkCLNKMCVYDPKKFEWKELAPMQ 497
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQ-SLNSVEVYDPETNTWSKLPSMP 46
BTB_POZ_ZBTB24_ZNF450 cd18212
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 43-116 2.15e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 24 (ZBTB24); ZBTB24, also called zinc finger protein 450, functions as a transcription factor essentially involved in B-cell functions in humans. The loss-of-function mutations in ZBTB24 can cause ICF2 (immunodeficiency, centromeric instability and facial anomalies syndrome 2) with immunological characteristics of greatly reduced serum antibodies and circulating memory B cells. ZBTB24 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349521 [Multi-domain]  Cd Length: 118  Bit Score: 44.02  E-value: 2.15e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45593142  43 EFPCHRLVLAACSPYFRARFLAEPERAGELH-LEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSI 116
Cdd:cd18212  34 QFRAHKALLAASSEYFSMMFADEGEVGQSIYmLEGMVAETFGALLEFIYTGCLQVGEKSLEQILATAQFLKVNDL 108
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 499-537 2.22e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.83  E-value: 2.22e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 45593142   499 ARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKW 537
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTW 39
BTB_POZ_ZBTB30_HIC2 cd18334
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 15-126 2.49e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 2 protein (Hic-2); Hic-2 is also called HIC1-related gene on chromosome 22 protein (HRG22), Hic-3, or zinc finger and BTB domain-containing protein 30 (ZBTB30). It is a homolog of tumor suppressor Hic-1. It functions as a transcriptional regulator. It is a dosage-dependent regulator of cardiac development located within the distal 22q11 deletion syndrome region. Hic-2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349643 [Multi-domain]  Cd Length: 120  Bit Score: 43.80  E-value: 2.49e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  15 QQTLLQdgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAepERAGELHLEEVSPDVVAQVLHYLYTSE- 93
Cdd:cd18334   6 KQLLLQ--LNQQRAKGFLCDVIIVVENALFRAHKNILAASSMYFKSLVLH--DNLINLDTDMVNPTVFRQILDFIYTGKl 81

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 45593142  94 IALDEASVQD---LFAAAHRFQIPSIFTICVSFLQK 126
Cdd:cd18334  82 LTSDQPGEQNfnaLLTAASYLQLHDLAALCRKKLKR 117
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 401-442 2.89e-05

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 41.44  E-value: 2.89e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 45593142   401 PRCLFGLGEALNSIYVVGGReikDGERCLDSVMCYDRLSFKW 442
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGF---DGNQSLNSVEVYDPETNTW 39
BTB_POZ_ZBTB26_Bioref cd18214
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 31-126 3.12e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 26 (ZBTB26); ZBTB26, also called zinc finger protein 481 (ZNF481) or zinc finger protein Bioref, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349523 [Multi-domain]  Cd Length: 122  Bit Score: 43.66  E-value: 3.12e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  31 KFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEEVSpDVVAQVLHYLYTSEIALDEASVQDLFAAAHR 110
Cdd:cd18214  24 KFCDVTVHIDDLEVPGHKVVFAAGSPFLRDQFLLNDSREVQISILQNS-EVGRQLLLSCYTGVLEFPEMELVNYLTAASF 102

                        90
                ....*....|....*.
gi 45593142 111 FQIPSIFTICVSFLQK 126
Cdd:cd18214 103 LQMSHIVERCTQALWK 118
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 21-113 4.13e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 43.07  E-value: 4.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  21 DGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRaRFLAEPERAGELHLEEVSPDVVAQVLHYLYTSEIAL-DEA 99
Cdd:cd18221   7 DRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFY-KFFQDFTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVqGEE 85

                        90
                ....*....|....
gi 45593142 100 SVQDLFAAAHRFQI 113
Cdd:cd18221  86 EANDVWKAAEYLQM 99
BTB_POZ_BTBD14B_NAC1 cd18290
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-126 4.59e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 1 (NAC-1); NAC-1, also called BTB/POZ domain-containing protein 14B (BTBD14B), is a transcriptional repressor that contributes to tumor progression, tumor cell proliferation, and survival. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349599 [Multi-domain]  Cd Length: 123  Bit Score: 43.49  E-value: 4.59e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   5 LEQAEEQRLyqqtllqdglkdmldHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHlEEVSPDVVAQ 84
Cdd:cd18290  15 LECLNEQRL---------------QGLYCDVSVVVKGHAFKAHRAVLAASSSYFRDLFNSSRSAVVELP-AAVQPQSFQQ 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 45593142  85 VLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFLQK 126
Cdd:cd18290  79 ILSFCYTGRLSMNVGDQFLLMYTAGFLQIQEIMEKGTEFFLK 120
Kelch smart00612
Kelch domain;
414-462 5.77e-05

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 40.62  E-value: 5.77e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 45593142    414 IYVVGGReikDGERCLDSVMCYDRLSFKWGESDPLPYVVYGHTVLSHMD 462
Cdd:smart00612   2 IYVVGGF---DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
BTB_POZ_ZBTB27_BCL6 cd18331
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 34-124 7.05e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349640 [Multi-domain]  Cd Length: 118  Bit Score: 42.54  E-value: 7.05e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  34 DCVVRAGEREFPCHRLVLAACSPYFRARFLAEPER-AGELHLE-EVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRF 111
Cdd:cd18331  26 DVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCnLSVINLDpEINPEGFNILLDFMYTSRLNLREGNIMAVMATAMYL 105

                        90
                ....*....|...
gi 45593142 112 QIPSIFTICVSFL 124
Cdd:cd18331 106 QMEHVVDTCRKFI 118
BTB_POZ_ZBTB45 cd18229
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-127 7.68e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 45 (ZBTB45); ZBTB45, also called zinc finger protein 499 (ZNF499), may act as a transcriptional regulator that is essential for proper glial differentiation of neural and oligodendrocyte progenitor cells. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349538 [Multi-domain]  Cd Length: 112  Bit Score: 42.54  E-value: 7.68e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLaeperAGELHLEE---VSPDVVAQVLHYLYTSEIALDEASVQDLFA 106
Cdd:cd18229  16 GHFCDVTVRIHDASLRAHRCVLAAGSPFFHDKLL-----LGHSEIEVppvVPAQTVRQLVEFMYSGSLVVAQSEALQILT 90

                        90       100
                ....*....|....*....|.
gi 45593142 107 AAHRFQIPSIFTICVSFLQKR 127
Cdd:cd18229  91 AASILQIKTVIDECTQIISQS 111
BTB_POZ_ZBTB43 cd18227
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-125 1.07e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349536 [Multi-domain]  Cd Length: 121  Bit Score: 42.23  E-value: 1.07e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLQDgLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERagELHLEEV-SPDVVAQVLHYLYTS 92
Cdd:cd18227   8 FSSTILQK-LNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFCDQVLLKNSR--RIVLPDVmNPRVFENILLSCYTG 84

                        90       100       110
                ....*....|....*....|....*....|...
gi 45593142  93 EIALDEASVQDLFAAAHRFQIPSIFTICVSFLQ 125
Cdd:cd18227  85 RLVLPAPEIVSYLTAASFLQMWHVVDKCTELLE 117
BTB_POZ_GCL cd18305
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 29-124 1.25e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein germ cell-less (GCL) and similar proteins; GCL proteins are nuclear envelope proteins highly conserved between the mammalian and Drosophila orthologs. Drosophila melanogaster GCL is a key regulator required for the specification of pole cells and primordial germ cell formation in embryos. Both, human germ cell-less protein-like 1 (GMCL1) and germ cell-less protein-like 2 (GMCL2), also called germ cell-less protein-like 1-like (GMCL1P1 or GMCL1L), may function in spermatogenesis. They may also be substrate-specific adaptors of E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. They contain BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349614 [Multi-domain]  Cd Length: 115  Bit Score: 41.88  E-value: 1.25e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  29 HGKFLDCVVRAGEREFPCHRLVLAACsPYFRARFLAE--PERAGELHLEEVSPDVVAQVLHY----LYTSEIALDEASVQ 102
Cdd:cd18305  12 NGENSDITICALGREWKLHKIYLCQS-GYFASMFSGSwkESKETVINLEIPDDNITVEALNVvfgsLYRDEIEIKPSRVV 90

                        90       100
                ....*....|....*....|..
gi 45593142 103 DLFAAAHRFQIPSIFTICVSFL 124
Cdd:cd18305  91 SILAAATLLQLDGLIQQCSEVM 112
BTB_POZ_ZBTB16_PLZF cd18205
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-124 2.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 16 (ZBTB16); ZBTB16 is also called promyelocytic leukemia zinc finger protein, zinc finger protein 145, or zinc finger protein PLZF. It is a DNA-binding transcription factor essential for undifferentiated cell maintenance. ZBTB16 also acts as a downstream transcriptional regulator of Osterix and can be useful as a late marker of osteoblastic differentiation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349514 [Multi-domain]  Cd Length: 107  Bit Score: 41.17  E-value: 2.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARFlaePERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAH 109
Cdd:cd18205  16 GTLCDVVIMVDSQEFHAHRTVLACTSKMFEILF---HRNSQHYTLDFLSPKTFQQILEYAYTATLQAKVEDLDDLLYAAE 92

                        90
                ....*....|....*
gi 45593142 110 RFQIPSIFTICVSFL 124
Cdd:cd18205  93 ILEIEYLEEQCLKIL 107
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 36-129 2.14e-04

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 41.91  E-value: 2.14e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  36 VVRAGEREFPCHRLVLAACSPYFRARFLAEPERAG----ELHLEEVSP------DVVAQVLHYLYTS--EIALDEAS--- 100
Cdd:cd18310  23 IIVEGGRPVPVHRCILAARSPFFRDIFASAKAEGAntkpKLELRELIPggivgyDAFMLVLSYLYSGrlRLVPKEGSacv 102

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 45593142 101 ---------------VQDLFAAAHRFQIPSIfticVSFLQKRLC 129
Cdd:cd18310 103 dsdcwhvacrpavdfALEVLYAASVFQIPEL----VSLFQRRLL 142
BTB_POZ_BTBD14A_NAC2 cd18289
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 30-116 3.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349598 [Multi-domain]  Cd Length: 131  Bit Score: 40.78  E-value: 3.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  30 GKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHlEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAH 109
Cdd:cd18289  27 GLYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFSGNSKSAFELP-ATVPPACFQQILSFCYTGKLTMAASEQLVVMYTAG 105


                ....*..
gi 45593142 110 RFQIPSI 116
Cdd:cd18289 106 FLQIQHI 112
BTB_POZ_ZBTB6 cd18197
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-124 3.94e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 6 (ZBTB6); ZBTB6, also called zinc finger protein 482 (ZNF482) or zinc finger protein with interaction domain, may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349506 [Multi-domain]  Cd Length: 116  Bit Score: 40.62  E-value: 3.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   5 LEQAEEQRLYQQTLLQDglkdmldHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPERAGELHLEEvSPDVVAQ 84
Cdd:cd18197   5 FEQQGDAVLQKMNLLRQ-------QNLFCDVSIYINDTEFHGHKVILAACSTFMRDQFLLNQSKQVRITILQ-SAEVGRK 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 45593142  85 VLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVSFL 124
Cdd:cd18197  77 LLLSCYTGALEVKKKELLKYLTAASYLQMVHIVEKCTEAL 116
BTB_POZ_ZBTB11 cd18202
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 5-122 8.01e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349511 [Multi-domain]  Cd Length: 118  Bit Score: 39.45  E-value: 8.01e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142   5 LEQAEEQRLYQQtllqdglkdmldhgkFLDCVVRAGEREFPCHRLVLAACSPYFRARFL---AEPERAGELHLEEVSPDV 81
Cdd:cd18202   7 LDQLNQQRLNNQ---------------FCDVTLLIEGEEYKAHKSVLAANSEYFRELFIekgAVSSHEAVVDLSGFCKSS 71

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 45593142  82 VAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTICVS 122
Cdd:cd18202  72 FLPLLEFAYTSELTFDFCSMAEVAMLARHLFMNEVLEICES 112
BTB_POZ_ZBTB20_DPZF cd18208
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 23-126 8.96e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20); ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349517 [Multi-domain]  Cd Length: 117  Bit Score: 39.28  E-value: 8.96e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  23 LKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLaeperAGELHLE---EVSPDVVAQVLHYLYTSEIALDEA 99
Cdd:cd18208  16 LNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLL-----LGYSDIEipsVVSVQSVQKLIDFMYSGVLRVSQS 90

                        90       100
                ....*....|....*....|....*..
gi 45593142 100 SVQDLFAAAHRFQIPSIFTICVSFLQK 126
Cdd:cd18208  91 EALQILTAASILQIKTVIDECTRIVSQ 117
PHA02713 PHA02713
hypothetical protein; Provisional
 464-564 1.09e-03

hypothetical protein; Provisional


Pssm-ID: 165086 [Multi-domain]  Cd Length: 557  Bit Score: 41.92  E-value: 1.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  464 VYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPMQTARSLFGATVHDGRIIVAAGVTDTGLTSSAEVYSITDNKWAPFEAF 543
Cdd:PHA02713 306 IIIAGGYNFNNPSLNKVYKINIENKIHVELPPMIKNRCRFSLAVIDDTIYAIGGQNGTNVERTIECYTMGDDKWKMLPDM 385

                         90       100
                 ....*....|....*....|.
gi 45593142  544 PQERSSLSLVSLVGTLYAIGG 564
Cdd:PHA02713 386 PIALSSYGMCVLDQYIYIIGG 406
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 547-594 1.30e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 36.82  E-value: 1.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 45593142   547 RSSLSLVSLVGTLYAIGGFAtletesgelVPTELNDIWRYNEEEKKWE 594
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFD---------GNQSLNSVEVYDPETNTWS 40
BACK_BTBD7 cd18489
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); ...
 155-214 1.31e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains and a BACK domain.


Pssm-ID: 350564  Cd Length: 98  Bit Score: 38.44  E-value: 1.31e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 155 FICAHFTLVARDADFLGLSADELIAIISSDGLNVeKEEAVFEAVMRWagsgdAEAQAERQ 214
Cdd:cd18489  29 FLREEFSQIAQSPVLFELTKEYLIEALQSDFLQA-SELDILKAVLKW-----GEHQLIKR 82
BACK_KLHL22 cd18461
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a ...
 132-199 1.33e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of Polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates monoubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation.


Pssm-ID: 350536  Cd Length: 104  Bit Score: 38.59  E-value: 1.33e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 45593142 132 NCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVM 199
Cdd:cd18461   5 NILDVYKLADLFHLTHLSEQLDSYILKNFPTFSRTETYRQLPLEKVYSLLSSNRLEVDSENEVYEGAL 72
BACK_KBTBD6_7 cd18482
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing ...
 128-225 2.77e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing proteins, KBTBD6 and KBTBD7; KBTBD6 and KBTBD7 are substrate adaptors of a cullin-3 RING ubiquitin ligase complex that mediates ubiquitylation and proteasomal degradation of T-lymphoma and metastasis gene 1 (TIAM1), a RAC1-specific guanine exchange factor (GEF), by cooperating with gamma-aminobutyric acid receptor-associated proteins (GABARAP). KBTBD7 may also act as a new transcriptional activator in mitogen-activated protein kinase (MAPK) signaling.


Pssm-ID: 350557 [Multi-domain]  Cd Length: 99  Bit Score: 37.48  E-value: 2.77e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 128 LCLSNCLAVFRLGLLLDCARLAVAARDFICAHF-TLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRWAGSgd 206
Cdd:cd18482   1 LDLSNCAGILKFADAFDNRELKSKALAFIARNFqQLLAKEEELCELSLAQLKEVLMLDSLDVDSERKVCSVAVQWIEA-- 78

                        90
                ....*....|....*....
gi 45593142 207 aeAQAERQRALPTVFESVR 225
Cdd:cd18482  79 --NLKERAASAAEVLKCVR 95
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 42-134 2.81e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 38.42  E-value: 2.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  42 REFPCHRLVLAACSPYFRARFLAEPERAGE-LHLEEVSPDVVAQVLHYLY---TSEIALDEASVQDLFAAAHRFQIPSIF 117
Cdd:cd18351  34 RPFYAHKVLLFTASPRFKALLSNKPSAENTcIEISYVKYHIFQLVMQYLYcggTESLLIKNNEIMELLSAAKFFQLEALQ 113

                        90
                ....*....|....*..
gi 45593142 118 TICVSFLQKRLCLSNCL 134
Cdd:cd18351 114 RHCEIICAKSINTENCV 130
BTB_POZ_ZBTB9 cd18200
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 14-96 3.03e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 9 (ZBTB9); ZBTB9 may be involved in transcriptional regulation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349509 [Multi-domain]  Cd Length: 111  Bit Score: 37.91  E-value: 3.03e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  14 YQQTLLqDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFLAEPerAGELHLEEV-SPDVVAQVLHYLYTS 92
Cdd:cd18200   1 YSSALL-ETLNKHRLEGKFCDLSVHVQGRVFRAHKAVLAASSPYFHDKLLLND--TNCLVLPSViEAAAFENLLQLIYSG 77


                ....
gi 45593142  93 EIAL 96
Cdd:cd18200  78 RLTL 81
Kelch_4 pfam13418
Galactose oxidase, central domain;
462-496 3.17e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 36.05  E-value: 3.17e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 45593142   462 DLVYVIGGKGSDRKCLNKMCVYDPKKFEWKELAPM 496
Cdd:pfam13418  13 DTIYLFGGEGEDGTLLSDLWVFDLSTNEWTRLGSL 47
BTB2_POZ_BTBD7 cd18284
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 37-96 4.55e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 7 (BTBD7); BTBD7 is a crucial regulator that is essential for region-specific epithelial cell dynamics and branching morphogenesis. It has been implicated in various cancers. BTBD7 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349593  Cd Length: 146  Bit Score: 38.09  E-value: 4.55e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 45593142  37 VRAGEREFPCHRLVLAACSPYFR-----------ARFLAEPERageLHLEE-VSPDVVAQV-LHYLYTSEIAL 96
Cdd:cd18284  23 VNEPDFELRCHKAILSARSPFFRnllqrrirtgeDRTLSTPTR---IVLDEsIIPRRYARVlLHAMYTDSVDL 92
BACK_KLHL9_13 cd18449
BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 ...
 128-201 5.07e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like proteins, KLHL9 and KLHL13; KLHL9 and KLHL13 (also termed BTB and kelch domain-containing protein 2, or BKLHD2) are substrate-specific adaptors of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.


Pssm-ID: 350524 [Multi-domain]  Cd Length: 95  Bit Score: 36.63  E-value: 5.07e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 45593142 128 LCLSNCLAVFRLGLLLDCARLAVAARDFICAHFTLVARDADFLGLSADELIAIISSDGLNVEKEEAVFEAVMRW 201
Cdd:cd18449   1 VSLENCVEIGRIANTYHLTEVDKYVNDFILKNFPALLSTGDFVKLPFERLAFVLSSNSLKGCTELELFKAACRW 74
BACK_KLHL15 cd18454
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a ...
 128-235 5.64e-03

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 15 (KLHL15); KLHL15 is a substrate-specific adaptor for Cullin3 E3 ubiquitin-protein ligase complex that target the serine/threonine-protein phosphatase 2A (PP2A) subunit PPP2R5B for ubiquitination and subsequent proteasomal degradation, thus promoting exchange with other regulatory subunits. It also plays a key role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR), by targeting the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation.


Pssm-ID: 350529  Cd Length: 108  Bit Score: 36.79  E-value: 5.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142 128 LCLSNCLAVFRL----GLLLDCARLAVAArdFICAHFTLVARDADFLG-LSADELIAIISSDGLNVEKEEAVFEAVMRWa 202
Cdd:cd18454   1 ICLDNCAEIMRLlddfSVNIEGVREKLDS--FLLENFVPLMSRPDFLSyLSFEKLMSYLDNDHLSRFPEIELYEAVQAW- 77

                        90       100       110
                ....*....|....*....|....*....|....
gi 45593142 203 gsgdAEAQAERQRALPTVFESVR-CRLLPRAFLE 235
Cdd:cd18454  78 ----LRHDRRRWRHTDTIIQNIRfCLMTPTNVFE 107
BTB_POZ_ZBTB22_BING1 cd18210
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 16-63 7.24e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349519 [Multi-domain]  Cd Length: 112  Bit Score: 36.74  E-value: 7.24e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 45593142  16 QTLLQDGLKDMLDHGKFLDCVVRAGEREFPCHRLVLAACSPYFRARFL 63
Cdd:cd18210   5 TSSLLESLNQQRMEGKLCDISIHVQGRVFRAHRAVLAASSPYFHDQVL 52
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 42-132 8.85e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 36.69  E-value: 8.85e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45593142  42 REFPCHRLVLAACSPYFRARF--LAEPERAGELHLEEVSPDVVAQVLHYLYTSEIALDEASVQDLFAAAHRFQIPSIFTI 119
Cdd:cd18352  23 RRFYAHRIALLASSDAFRAMFdgGYREKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLLRAADQYLLEGLKRL 102

                        90
                ....*....|...
gi 45593142 120 CVSFLQKRLCLSN 132
Cdd:cd18352 103 CEYTIAQDLTLEN 115
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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