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Conserved domains on  [gi|23097254|ref|NP_690869|]
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protein NEDD1 isoform b [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-299 3.96e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 3.96e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254  24 LVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVnLNSTSMYLVSGGLNNTVNI 103
Cdd:cd00200   1 LRRTLKGHTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-ASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 104 WDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPF-GHgsNQSVRHLKYSLFKKSLLGSvS 182
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGTFVASS-S 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 183 DNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGA 261
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGY 232

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 23097254 262 TLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 299
Cdd:cd00200 233 LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-299 3.96e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 3.96e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254  24 LVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVnLNSTSMYLVSGGLNNTVNI 103
Cdd:cd00200   1 LRRTLKGHTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-ASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 104 WDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPF-GHgsNQSVRHLKYSLFKKSLLGSvS 182
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGTFVASS-S 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 183 DNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGA 261
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGY 232

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 23097254 262 TLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 299
Cdd:cd00200 233 LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
5-299 3.28e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.99  E-value: 3.28e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254   5 LRFASSGDDIKIWDASSMTLVDKFNPHTSPhgISSICWSSNNNFLVTASSsgDKIVVssckckpvpLLELAEGQKQ---- 80
Cdd:COG2319  93 LASASADGTVRLWDLATGLLLRTLTGHTGA--VRSVAFSPDGKTLASGSA--DGTVR---------LWDLATGKLLrtlt 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254  81 ------TCVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSS 154
Cdd:COG2319 160 ghsgavTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 155 TPFGHGSNqSVRHLKYSLfKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIGLDKRIILY 234
Cdd:COG2319 240 RTLTGHSG-SVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLL-ASGSDDGTVRLW 315

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 23097254 235 DTSSKKLVKTLVADT-PLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKsPVKTISAHKTSVQCIAF 299
Cdd:COG2319 316 DLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAF 380
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 173-309 3.30e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 3.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254  173 FKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLT 252
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDVARSQLVTEMKE-HEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC 621

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 23097254  253 AVDFMPD-GATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTVLTKSS 309
Cdd:PLN00181 622 CVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSS 679
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-147 3.66e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.66e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 23097254    108 SKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHS 147
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 24-299 3.96e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 181.38  E-value: 3.96e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254  24 LVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIVVSSCKCKPVPLLELAEGQKQTCVnLNSTSMYLVSGGLNNTVNI 103
Cdd:cd00200   1 LRRTLKGHTGG--VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVA-ASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 104 WDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPF-GHgsNQSVRHLKYSLFKKSLLGSvS 182
Cdd:cd00200  78 WDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLrGH--TDWVNSVAFSPDGTFVASS-S 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 183 DNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTiGLDKRIILYDTSSKKLVKTLVADT-PLTAVDFMPDGA 261
Cdd:cd00200 155 QDGTIKLWDLRTGKCVATLTG-HTGEVNSVAFSPDGEKLLSS-SSDGTIKLWDLSTGKCLGTLRGHEnGVNSVAFSPDGY 232

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 23097254 262 TLAIGSSRGKIYQYDLRMlKSPVKTISAHKTSVQCIAF 299
Cdd:cd00200 233 LLASGSEDGTIRVWDLRT-GECVQTLSGHTNSVTSLAW 269
WD40 COG2319
WD40 repeat [General function prediction only];
5-299 3.28e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 151.99  E-value: 3.28e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254   5 LRFASSGDDIKIWDASSMTLVDKFNPHTSPhgISSICWSSNNNFLVTASSsgDKIVVssckckpvpLLELAEGQKQ---- 80
Cdd:COG2319  93 LASASADGTVRLWDLATGLLLRTLTGHTGA--VRSVAFSPDGKTLASGSA--DGTVR---------LWDLATGKLLrtlt 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254  81 ------TCVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSS 154
Cdd:COG2319 160 ghsgavTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 155 TPFGHGSNqSVRHLKYSLfKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIGLDKRIILY 234
Cdd:COG2319 240 RTLTGHSG-SVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLTG-HSGGVNSVAFSPDGKLL-ASGSDDGTVRLW 315

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 23097254 235 DTSSKKLVKTLVADT-PLTAVDFMPDGATLAIGSSRGKIYQYDLRMLKsPVKTISAHKTSVQCIAF 299
Cdd:COG2319 316 DLATGKLLRTLTGHTgAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE-LLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
6-278 6.19e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 6.19e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254   6 RFASSGDD--IKIWDASSMTLVDKFNPHTSPhgISSICWSSNNNFLVTASSsgDKIV----VSSCKCkpvpLLELAEGQK 79
Cdd:COG2319 134 TLASGSADgtVRLWDLATGKLLRTLTGHSGA--VTSVAFSPDGKLLASGSD--DGTVrlwdLATGKL----LRTLTGHTG 205

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254  80 Q-TCVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFG 158
Cdd:COG2319 206 AvRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLT 285

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 159 HGSNqSVRHLKYSLFKKSLLgSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIGLDKRIILYDTSS 238
Cdd:COG2319 286 GHSG-GVNSVAFSPDGKLLA-SGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 23097254 239 KKLVKTLVADT-PLTAVDFMPDGATLAIGSSRGKIYQYDLR 278
Cdd:COG2319 362 GELLRTLTGHTgAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
91-299 1.68e-28

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 118.09  E-value: 1.68e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254  91 YLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTT-NLSSTPFGHGSnqSVRHLK 169
Cdd:COG2319  92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATgKLLRTLTGHSG--AVTSVA 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 170 YSLfKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT 249
Cdd:COG2319 170 FSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG-HTGAVRSVAFSPDGKLL-ASGSADGTVRLWDLATGKLLRTLTGHS 246

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 23097254 250 -PLTAVDFMPDGATLAIGSSRGKIYQYDLRmLKSPVKTISAHKTSVQCIAF 299
Cdd:COG2319 247 gSVRSVAFSPDGRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAF 296
WD40 COG2319
WD40 repeat [General function prediction only];
92-299 1.26e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.67  E-value: 1.26e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254  92 LVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTNLSSTPF-GHGSnqSVRHLKY 170
Cdd:COG2319  51 LAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLtGHTG--AVRSVAF 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 171 SLFKKSLLgSVSDNGIVTLWDVNSQSPYHNFdSVHKAPASGICFSPVNELLfVTIGLDKRIILYDTSSKKLVKTLVADT- 249
Cdd:COG2319 129 SPDGKTLA-SGSADGTVRLWDLATGKLLRTL-TGHSGAVTSVAFSPDGKLL-ASGSDDGTVRLWDLATGKLLRTLTGHTg 205

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 23097254 250 PLTAVDFMPDGATLAIGSSRGKIYQYDLRmLKSPVKTISAHKTSVQCIAF 299
Cdd:COG2319 206 AVRSVAFSPDGKLLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAF 254
WD40 COG2319
WD40 repeat [General function prediction only];
6-194 2.50e-20

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 93.82  E-value: 2.50e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254   6 RFASSGDD--IKIWDASSMTLVDKFNPHTSPhgISSICWSSNNNFLvtASSSGDKIV----VSSCKCkpvplLELAEGQK 79
Cdd:COG2319 218 LLASGSADgtVRLWDLATGKLLRTLTGHSGS--VRSVAFSPDGRLL--ASGSADGTVrlwdLATGEL-----LRTLTGHS 288

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254  80 Q--TCVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHSVTTN-LSSTP 156
Cdd:COG2319 289 GgvNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGeLLRTL 368

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 23097254 157 FGHGSnqSVRHLKYSLfKKSLLGSVSDNGIVTLWDVNS 194
Cdd:COG2319 369 TGHTG--AVTSVAFSP-DGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-145 7.62e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.31  E-value: 7.62e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254   8 ASSGDD--IKIWDASSMTLVDKFNPHTSPhgISSICWSSNNNFLVTASSSGDKIV--VSSCKCkpvplLELAEGQKQ--T 81
Cdd:cd00200 151 ASSSQDgtIKLWDLRTGKCVATLTGHTGE--VNSVAFSPDGEKLLSSSSDGTIKLwdLSTGKC-----LGTLRGHENgvN 223

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23097254  82 CVNLNSTSMYLVSGGLNNTVNIWDLKSKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIIL 145
Cdd:cd00200 224 SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRI 287
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 4-105 1.15e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.88  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254   4 NLRFASSGDD--IKIWDASSMTLVDKFNPHTSPhgISSICWSSNNNFLVTASSSGdKIVV-SSCKCKPVplLELAEGQKQ 80
Cdd:cd00200 189 GEKLLSSSSDgtIKLWDLSTGKCLGTLRGHENG--VNSVAFSPDGYLLASGSEDG-TIRVwDLRTGECV--QTLSGHTNS 263

                        90       100
                ....*....|....*....|....*.
gi 23097254  81 -TCVNLNSTSMYLVSGGLNNTVNIWD 105
Cdd:cd00200 264 vTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 173-309 3.30e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 3.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254  173 FKKSLLGSVSDNGIVTLWDVNSQSPYHNFDSvHKAPASGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLT 252
Cdd:PLN00181 543 YIKSQVASSNFEGVVQVWDVARSQLVTEMKE-HEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANIC 621

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 23097254  253 AVDFMPD-GATLAIGSSRGKIYQYDLRMLKSPVKTISAHKTSVQCIAFQYSTVLTKSS 309
Cdd:PLN00181 622 CVQFPSEsGRSLAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSS 679
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
125-288 4.91e-05

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 45.46  E-value: 4.91e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 125 VTYNWNDCYIASGSLSGEIILHSVTTNLSSTPFGHGSNQSVRHLKYSLFKKSLLGSVSDNGIVTLWDVNSQSPYHNFDsV 204
Cdd:COG3391  30 LGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATIP-V 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23097254 205 HKAPaSGICFSPVNELLFVTIGLDKRIILYDTSSKKLVKTLVADTPLTAVDFMPDGATLAIGSSRGK-----IYQYDLRM 279
Cdd:COG3391 109 GGGP-RGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATIPVGAGPHGIAVDPDGKRLYVANSGSNtvsviVSVIDTAT 187


                ....*....
gi 23097254 280 LKsPVKTIS 288
Cdd:COG3391 188 GK-VVATIP 195
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 108-147 3.66e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 3.66e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 23097254    108 SKRVHRSLKDHKDQVTCVTYNWNDCYIASGSLSGEIILHS 147
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 210-279 9.10e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 41.83  E-value: 9.10e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 23097254 210 SGICF-SPVNELLFVTIGLDKRIILYDTSSKK--LVKTLVADTPLTAVDFMPDGATLAIGSSRGKIYQYDLRM 279
Cdd:cd22857 182 TDLTFlSKDDHRKIVTGTGYHQVRLYDTRAQRrpVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRT 254
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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