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Conserved domains on  [gi|227498519|ref|NP_694777|]
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TRAF3-interacting JNK-activating modulator [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CC1_T3JAM cd21912
first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator; ...
 190-234 3.36e-12

first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator; TRAF3-interacting JNK-activating modulator (T3JAM), also called TRAF3-interacting protein 3 (TRAF3IP3), is a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK. It may function as an adapter molecule that regulates TRAF3-mediated JNK activation. The model corresponds to a conserved region that shows high sequence similarity with the first CC (CC1) domain of Sarcolemmal membrane-associated protein (SLMAP), which is responsible for the binding of suppressor of IKBKE 1 (SIKE1).


:

Pssm-ID: 409288 [Multi-domain]  Cd Length: 45  Bit Score: 60.82  E-value: 3.36e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 227498519 190 VLDKDIIQLSEYLKEALHRELILKKKMVILQDLLPALIRASDSSW 234
Cdd:cd21912    1 VLEKEILQLSDYLQEALHRERALKKKLAALQELLSTLLQASEKSW 45
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 298-485 1.04e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.02  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 298 AEQQLQRAQLSLALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQT 377
Cdd:COG1196  237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 378 KLESLQGDGEQQSSETQDLQDQLKKSEEEKQALVSKVQQLQSLLQNQSLQLQEQEKLLKKDQglpvwnpKLSLDEVKPEG 457
Cdd:COG1196  317 RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE-------EELEELAEELL 389

                        170       180
                 ....*....|....*....|....*...
gi 227498519 458 TRKEKEEELRDQLQKETFQLQVKEKELQ 485
Cdd:COG1196  390 EALRAAAELAAQLEELEEAEEALLERLE 417
 
Name Accession Description Interval E-value
CC1_T3JAM cd21912
first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator; ...
 190-234 3.36e-12

first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator; TRAF3-interacting JNK-activating modulator (T3JAM), also called TRAF3-interacting protein 3 (TRAF3IP3), is a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK. It may function as an adapter molecule that regulates TRAF3-mediated JNK activation. The model corresponds to a conserved region that shows high sequence similarity with the first CC (CC1) domain of Sarcolemmal membrane-associated protein (SLMAP), which is responsible for the binding of suppressor of IKBKE 1 (SIKE1).


Pssm-ID: 409288 [Multi-domain]  Cd Length: 45  Bit Score: 60.82  E-value: 3.36e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 227498519 190 VLDKDIIQLSEYLKEALHRELILKKKMVILQDLLPALIRASDSSW 234
Cdd:cd21912    1 VLEKEILQLSDYLQEALHRERALKKKLAALQELLSTLLQASEKSW 45
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 298-485 1.04e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.02  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 298 AEQQLQRAQLSLALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQT 377
Cdd:COG1196  237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 378 KLESLQGDGEQQSSETQDLQDQLKKSEEEKQALVSKVQQLQSLLQNQSLQLQEQEKLLKKDQglpvwnpKLSLDEVKPEG 457
Cdd:COG1196  317 RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE-------EELEELAEELL 389

                        170       180
                 ....*....|....*....|....*...
gi 227498519 458 TRKEKEEELRDQLQKETFQLQVKEKELQ 485
Cdd:COG1196  390 EALRAAAELAAQLEELEEAEEALLERLE 417
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 241-410 1.58e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.21  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   241 DKLKGKLRSLENQLYTCLQKHSpwGMKKVLLEMEDQRSSYEQK---AKASLQKVLEEKMCAEQQLQRAQLSLALAEQKCQ 317
Cdd:TIGR02168  708 EELEEELEQLRKELEELSRQIS--ALRKDLARLEAEVEQLEERiaqLSKELTELEAEIEELEERLEEAEEELAEAEAEIE 785

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   318 EWKSQYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQTKLESLQGDGEQQSSETQDLQ 397
Cdd:TIGR02168  786 ELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELE 865

                          170
                   ....*....|...
gi 227498519   398 DQLKKSEEEKQAL 410
Cdd:TIGR02168  866 ELIEELESELEAL 878
PRK12704 PRK12704
phosphodiesterase; Provisional
 285-414 6.15e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 6.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 285 KASLQKVLEEKMCAEQQLQRAQLSL-ALAEQKCQEWKSQYEALKEDW-RTLGDQHRELESQLHVLQSKLQGADSRDSQMS 362
Cdd:PRK12704  27 KIAEAKIKEAEEEAKRILEEAKKEAeAIKKEALLEAKEEIHKLRNEFeKELRERRNELQKLEKRLLQKEENLDRKLELLE 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 227498519 363 QALQLLENEHQELQTKLESLqgdgEQQSSETQDLQDQLKK---------SEEEKQALVSKV 414
Cdd:PRK12704 107 KREEELEKKEKELEQKQQEL----EKKEEELEELIEEQLQelerisgltAEEAKEILLEKV 163
 
Name Accession Description Interval E-value
CC1_T3JAM cd21912
first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator; ...
 190-234 3.36e-12

first coiled-coil (CC1) domain found in TRAF3-interacting JNK-activating modulator; TRAF3-interacting JNK-activating modulator (T3JAM), also called TRAF3-interacting protein 3 (TRAF3IP3), is a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK. It may function as an adapter molecule that regulates TRAF3-mediated JNK activation. The model corresponds to a conserved region that shows high sequence similarity with the first CC (CC1) domain of Sarcolemmal membrane-associated protein (SLMAP), which is responsible for the binding of suppressor of IKBKE 1 (SIKE1).


Pssm-ID: 409288 [Multi-domain]  Cd Length: 45  Bit Score: 60.82  E-value: 3.36e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 227498519 190 VLDKDIIQLSEYLKEALHRELILKKKMVILQDLLPALIRASDSSW 234
Cdd:cd21912    1 VLEKEILQLSDYLQEALHRERALKKKLAALQELLSTLLQASEKSW 45
CC1_SLMAP cd21911
first coiled-coil (CC1) domain found in Sarcolemmal membrane-associated protein; Sarcolemmal ...
 194-254 3.74e-11

first coiled-coil (CC1) domain found in Sarcolemmal membrane-associated protein; Sarcolemmal membrane-associated protein (SLMAP), also called Sarcolemmal membrane-associated protein, is a cardiac tail-anchored membrane protein that may play a role during myoblast fusion. SLMAP contains an N-terminal FHA domain followed by four coiled-coil (CC) domains and a transmembrane domain. The model corresponds to the first CC (CC1) domain that is responsible for the binding of suppressor of IKBKE 1 (SIKE1).


Pssm-ID: 409287 [Multi-domain]  Cd Length: 63  Bit Score: 58.46  E-value: 3.74e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 227498519 194 DIIQLSEYLKEALHRELILKKKMVILQDLLPALIRASDSSWKGQLNEDKLKGKLRSLENQL 254
Cdd:cd21911    2 ELFQLQQYLQEALHREQILEQKLETLQRLLSSTQEASESSWQALIDEDRLLSRLELLENQL 62
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 298-485 1.04e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 58.02  E-value: 1.04e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 298 AEQQLQRAQLSLALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQT 377
Cdd:COG1196  237 LEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEE 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 378 KLESLQGDGEQQSSETQDLQDQLKKSEEEKQALVSKVQQLQSLLQNQSLQLQEQEKLLKKDQglpvwnpKLSLDEVKPEG 457
Cdd:COG1196  317 RLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE-------EELEELAEELL 389

                        170       180
                 ....*....|....*....|....*...
gi 227498519 458 TRKEKEEELRDQLQKETFQLQVKEKELQ 485
Cdd:COG1196  390 EALRAAAELAAQLEELEEAEEALLERLE 417
CC1_SLMAP-like cd21868
first coiled-coil (CC1) domain found in Sarcolemmal membrane-associated protein and similar ...
 197-234 2.27e-08

first coiled-coil (CC1) domain found in Sarcolemmal membrane-associated protein and similar proteins; The family includes Sarcolemmal membrane-associated protein (SLMAP), its paralog TRAF3-interacting JNK-activating modulator (T3JAM), and similar proteins. SLMAP, also called Sarcolemmal membrane-associated protein, is a cardiac tail-anchored membrane protein that may play a role during myoblast fusion. T3JAM, also called TRAF3-interacting protein 3 (TRAF3IP3), is a novel protein that specifically interacts with TRAF3 and promotes the activation of JNK. It may function as an adapter molecule that regulates TRAF3-mediated JNK activation. SLMAP contains an N-terminal FHA domain, followed by four coiled-coil (CC) domains and a transmembrane domain. The model corresponds to the first CC (CC1) domain that is responsible for the binding of suppressor of IKBKE 1 (SIKE1).


Pssm-ID: 409286 [Multi-domain]  Cd Length: 38  Bit Score: 49.79  E-value: 2.27e-08
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 227498519 197 QLSEYLKEALHRELILKKKMVILQDLLPALIRASDSSW 234
Cdd:cd21868    1 QLNQYIQEALQREQSLENKLANLQEILEATKKAAEESW 38
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 241-410 1.58e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 51.21  E-value: 1.58e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   241 DKLKGKLRSLENQLYTCLQKHSpwGMKKVLLEMEDQRSSYEQK---AKASLQKVLEEKMCAEQQLQRAQLSLALAEQKCQ 317
Cdd:TIGR02168  708 EELEEELEQLRKELEELSRQIS--ALRKDLARLEAEVEQLEERiaqLSKELTELEAEIEELEERLEEAEEELAEAEAEIE 785

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   318 EWKSQYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQTKLESLQGDGEQQSSETQDLQ 397
Cdd:TIGR02168  786 ELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELE 865

                          170
                   ....*....|...
gi 227498519   398 DQLKKSEEEKQAL 410
Cdd:TIGR02168  866 ELIEELESELEAL 878
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 242-414 8.77e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.51  E-value: 8.77e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   242 KLKGKLRSLENQLYTclqkhspwgmkKVLLEMEDQRSSYEQKAKASLQKVLEekmcAEQQLQRAQLSLALAEQKCQEWKS 321
Cdd:TIGR02168  217 ELKAELRELELALLV-----------LRLEELREELEELQEELKEAEEELEE----LTAELQELEEKLEELRLEVSELEE 281

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   322 QYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQTKLESLQGDGEQQSSETQDLQDQLK 401
Cdd:TIGR02168  282 EIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELE 361

                          170
                   ....*....|...
gi 227498519   402 KSEEEKQALVSKV 414
Cdd:TIGR02168  362 ELEAELEELESRL 374
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 298-485 1.28e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.01  E-value: 1.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 298 AEQQLQRAQLSLALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQT 377
Cdd:COG1196  314 LEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALR 393

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 378 KLESLQGDGEQQSSETQDLQDQLKKSEEEKQALVSKVQQLQSLLQNQSLQLQEQEKLLKKDQGLpvwnPKLSLDEVKPEG 457
Cdd:COG1196  394 AAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEE----EEALLELLAELL 469

                        170       180
                 ....*....|....*....|....*...
gi 227498519 458 TRKEKEEELRDQLQKETFQLQVKEKELQ 485
Cdd:COG1196  470 EEAALLEAALAELLEELAEAAARLLLLL 497
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
268-410 2.45e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.22  E-value: 2.45e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519  268 KVLLEMEDQRSSYEQ-KAKASLQKVLEEKmcaeQQLQRAQLSLALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHV 346
Cdd:COG4913   252 ELLEPIRELAERYAAaRERLAELEYLRAA----LRLWFAQRRLELLEAELEELRAELARLEAELERLEARLDALREELDE 327

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 227498519  347 LQSKLQGADSRD-SQMSQALQLLENEHQELQTKLESLQGD----GEQQSSETQDLQDQLKKSEEEKQAL 410
Cdd:COG4913   328 LEAQIRGNGGDRlEQLEREIERLERELEERERRRARLEALlaalGLPLPASAEEFAALRAEAAALLEAL 396
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 282-485 4.74e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.08  E-value: 4.74e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 282 QKAKASLQKVLEEKMCAEQQLQRAQLSLALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQM 361
Cdd:COG1196  263 AELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEEL 342

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 362 SQALQLLENEHQELQTKLESLQG---DGEQQSSETQDLQDQLKKSE-EEKQALVSKVQQLQSLLQNQSLQLQEQEKLLKK 437
Cdd:COG1196  343 EEELEEAEEELEEAEAELAEAEEallEAEAELAEAEEELEELAEELlEALRAAAELAAQLEELEEAEEALLERLERLEEE 422

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 227498519 438 DQGLPVwnpKLSLDEVKPEGTRKEKEEELRDQLQKETFQLQVKEKELQ 485
Cdd:COG1196  423 LEELEE---ALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAE 467
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 269-485 9.69e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 9.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   269 VLLEMEDQRSSYEQKAKASlQKVLEEKmcaeQQLQRAQLSLALAEqkcqewksqYEALKEDWRTLGDQHRELESQLHVLQ 348
Cdd:TIGR02168  194 ILNELERQLKSLERQAEKA-ERYKELK----AELRELELALLVLR---------LEELREELEELQEELKEAEEELEELT 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   349 SKLQGADSRdsqmsqaLQLLENEHQELQTKLESLQGDGEQQSSETQDLQDQLKKSEEEKQALVSKVQQLQSLLQNQSLQL 428
Cdd:TIGR02168  260 AELQELEEK-------LEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKL 332

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 227498519   429 QEQEKLLKKdqglpvWNPKLSLDEVKPEGTRkEKEEELRDQLQKETFQLQVKEKELQ 485
Cdd:TIGR02168  333 DELAEELAE------LEEKLEELKEELESLE-AELEELEAELEELESRLEELEEQLE 382
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
299-478 9.93e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.29  E-value: 9.93e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519  299 EQQLQRAQLSLALAE---QKCQEWKSQYEALKEDWRTLGDQ------HRELESQLHVLQSKLQGADSRDSQmsqaLQLLE 369
Cdd:COG4913   616 EAELAELEEELAEAEerlEALEAELDALQERREALQRLAEYswdeidVASAEREIAELEAELERLDASSDD----LAALE 691

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519  370 NEHQELQTKLESLQGDGEQQSSETQDLQDQLKKSEEEKQALvskvqqlqsllqnqslqlqeqEKLLKKDQGLPVWNPKLS 449
Cdd:COG4913   692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDEL---------------------QDRLEAAEDLARLELRAL 750

                         170       180
                  ....*....|....*....|....*....
gi 227498519  450 LDEVKPEGTRKEKEEELRDQLQKETFQLQ 478
Cdd:COG4913   751 LEERFAAALGDAVERELRENLEERIDALR 779
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
236-414 1.09e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 44.91  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519  236 GQLNEDKLKGK---LRSLENQLYTCLQKHSpwGMKKVLLEMEDQRSSYEQKAK--------ASLQKVLEEKmcaEQQLQR 304
Cdd:COG4913   605 GFDNRAKLAALeaeLAELEEELAEAEERLE--ALEAELDALQERREALQRLAEyswdeidvASAEREIAEL---EAELER 679

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519  305 AQLS---LALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQMSQALQllENEHQELQTKLES 381
Cdd:COG4913   680 LDASsddLAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLAR--LELRALLEERFAA 757

                         170       180       190
                  ....*....|....*....|....*....|...
gi 227498519  382 LQGDgEQQSSETQDLQDQLKKSEEEKQALVSKV 414
Cdd:COG4913   758 ALGD-AVERELRENLEERIDALRARLNRAEEEL 789
PRK12704 PRK12704
phosphodiesterase; Provisional
 285-414 6.15e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 6.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 285 KASLQKVLEEKMCAEQQLQRAQLSL-ALAEQKCQEWKSQYEALKEDW-RTLGDQHRELESQLHVLQSKLQGADSRDSQMS 362
Cdd:PRK12704  27 KIAEAKIKEAEEEAKRILEEAKKEAeAIKKEALLEAKEEIHKLRNEFeKELRERRNELQKLEKRLLQKEENLDRKLELLE 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 227498519 363 QALQLLENEHQELQTKLESLqgdgEQQSSETQDLQDQLKK---------SEEEKQALVSKV 414
Cdd:PRK12704 107 KREEELEKKEKELEQKQQEL----EKKEEELEELIEEQLQelerisgltAEEAKEILLEKV 163
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 309-410 1.10e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.97  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   309 LALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQTKLESLQGDGEQ 388
Cdd:TIGR02168  679 IEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTE 758

                           90       100
                   ....*....|....*....|..
gi 227498519   389 QSSETQDLQDQLKKSEEEKQAL 410
Cdd:TIGR02168  759 LEAEIEELEERLEEAEEELAEA 780
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 271-455 1.32e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 41.58  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   271 LEMEDQRSSYEQKAKASLQKVLEEkmcAEQQLQRAQLSLALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHVLQSK 350
Cdd:TIGR02168  325 LEELESKLDELAEELAELEEKLEE---LKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNE 401

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   351 LQGADSRDSQMSQALQ------------LLENEHQELQTKLESLQGDGEQQSSETQDLQDQLKKSEEE----KQALVSKV 414
Cdd:TIGR02168  402 IERLEARLERLEDRRErlqqeieellkkLEEAELKELQAELEELEEELEELQEELERLEEALEELREEleeaEQALDAAE 481

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 227498519   415 QQLQSLLQNQSLQLQEQEKLLKKDQGLP-VWNPKLSLDEVKP 455
Cdd:TIGR02168  482 RELAQLQARLDSLERLQENLEGFSEGVKaLLKNQSGLSGILG 523
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
272-410 2.30e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 40.52  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 272 EMEDQRSSYEQKAKAsLQKVLEEKMCAEQQLQRAQLSLALAEQKCQEWK--SQYEALKEDWRTLGDQHRELESQLHVLQS 349
Cdd:COG4717   82 EAEEKEEEYAELQEE-LEELEEELEELEAELEELREELEKLEKLLQLLPlyQELEALEAELAELPERLEELEERLEELRE 160

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 227498519 350 KLQGADSRDSQMSQALQLLENEHQELQTK----LESLQGDGEQQSSETQDLQDQLKKSEEEKQAL 410
Cdd:COG4717  161 LEEELEELEAELAELQEELEELLEQLSLAteeeLQDLAEELEELQQRLAELEEELEEAQEELEEL 225
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
241-399 2.51e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 40.39  E-value: 2.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 241 DKLKGKLRSLENQLYTCLQKHSpwgmkkvLLEMEDQRSSYEQK---AKASLQKVLEEKMCAEQQLQRAQLSLALAEQKC- 316
Cdd:COG3206  185 PELRKELEEAEAALEEFRQKNG-------LVDLSEEAKLLLQQlseLESQLAEARAELAEAEARLAALRAQLGSGPDALp 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 317 --------QEWKSQYEALKEDW----RTLGDQH---RELESQLHVLQSKLQgadsrdSQMSQALQLLENEHQELQTKLES 381
Cdd:COG3206  258 ellqspviQQLRAQLAELEAELaelsARYTPNHpdvIALRAQIAALRAQLQ------QEAQRILASLEAELEALQAREAS 331

                        170
                 ....*....|....*...
gi 227498519 382 LQGDGEQQSSETQDLQDQ 399
Cdd:COG3206  332 LQAQLAQLEARLAELPEL 349
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 298-410 2.62e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 40.81  E-value: 2.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   298 AEQQLQRAQLSLALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQT 377
Cdd:TIGR02168  682 LEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEA 761

                           90       100       110
                   ....*....|....*....|....*....|...
gi 227498519   378 KLESLQgdgeqqsSETQDLQDQLKKSEEEKQAL 410
Cdd:TIGR02168  762 EIEELE-------ERLEEAEEELAEAEAEIEEL 787
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 237-405 5.67e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.65  E-value: 5.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   237 QLNEDKLKGKLRSLENQLYTCLQKHSPWGMKKVLLE--MEDQRSSYEQKAKASLQKVLEEKMC------AEQQLQRAQLS 308
Cdd:TIGR02168  336 AEELAELEEKLEELKEELESLEAELEELEAELEELEsrLEELEEQLETLRSKVAQLELQIASLnneierLEARLERLEDR 415

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   309 LA--LAEQKCQEWKSQYEALKEDWRTLGDQHRELE---SQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQTKLESLQ 383
Cdd:TIGR02168  416 RErlQQEIEELLKKLEEAELKELQAELEELEEELEelqEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLE 495

                          170       180
                   ....*....|....*....|..
gi 227498519   384 GDGEQQSSETQDLQDQLKKSEE 405
Cdd:TIGR02168  496 RLQENLEGFSEGVKALLKNQSG 517
46 PHA02562
endonuclease subunit; Provisional
 300-414 6.66e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 39.23  E-value: 6.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 300 QQLQRAQLSLALAEQKCQEWKSQYEALKEDWrtlgDQHRELESQLHVLQSKLQGADSRDSQMSQALQLLENEHQELQTKL 379
Cdd:PHA02562 292 QQISEGPDRITKIKDKLKELQHSLEKLDTAI----DELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAI 367

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 227498519 380 ESLQGDGEQQSSETQDLQDQLKKSEEEKQALVSKV 414
Cdd:PHA02562 368 EELQAEFVDNAEELAKLQDELDKIVKTKSELVKEK 402
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
241-410 6.86e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 38.98  E-value: 6.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 241 DKLKGKLRSLENQLYTCLQKhspwgmKKVLLEMEDQRSSYEQKAKASLQKVleEKMCAEQQLQRAQLSLALAEQKCQEWK 320
Cdd:COG4717   74 KELEEELKEAEEKEEEYAEL------QEELEELEEELEELEAELEELREEL--EKLEKLLQLLPLYQELEALEAELAELP 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519 321 SQYEALK---EDWRTLGDQHRELESQLHVLQSKLQGADSRDS-QMSQALQLLENEHQELQTKLESLQGDGEQQSSETQDL 396
Cdd:COG4717  146 ERLEELEerlEELRELEEELEELEAELAELQEELEELLEQLSlATEEELQDLAEELEELQQRLAELEEELEEAQEELEEL 225

                        170
                 ....*....|....
gi 227498519 397 QDQLKKSEEEKQAL 410
Cdd:COG4717  226 EEELEQLENELEAA 239
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 268-413 7.64e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 39.28  E-value: 7.64e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   268 KVLLEMEDQRSSYEQKAKaSLQKVLEEKMCAEQQLQRAQLSLALAEQKCQEWKSQYEALKEDWRTLGDQHRELESQLHVL 347
Cdd:TIGR02169  333 KLLAEIEELEREIEEERK-RRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRL 411

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227498519   348 QSKLQGADSRDSQMSQALQLLENEHQELQT--------------KLESLQGDGEQQSSETQDLQDQLKKSEEEKQALVSK 413
Cdd:TIGR02169  412 QEELQRLSEELADLNAAIAGIEAKINELEEekedkaleikkqewKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRE 491
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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