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Conserved domains on  [gi|23346617|ref|NP_694808|]
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probable leucine--tRNA ligase, mitochondrial isoform 1 [Mus musculus]

Protein Classification

nucleotidyl transferase family protein( domain architecture ID 117)

nucleotidyl transferase (NT) family protein contains a conserved dinucleotide-binding domain; the NT superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and cytidylyltransferases

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
nt_trans super family cl00015
nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily ...
58-900 0e+00

nucleotidyl transferase superfamily; nt_trans (nucleotidyl transferase) This superfamily includes the class I amino-acyl tRNA synthetases, pantothenate synthetase (PanC), ATP sulfurylase, and the cytidylyltransferases, all of which have a conserved dinucleotide-binding domain.


The actual alignment was detected with superfamily member TIGR00396:

Pssm-ID: 444652 [Multi-domain]  Cd Length: 842  Bit Score: 847.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    58 VEKWWHQQIKEQASRVSEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENA 137
Cdd:TIGR00396   6 IEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLPAENA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   138 AIERNLHPESWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANE 217
Cdd:TIGR00396  86 AIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGTVLANE 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   218 QVNEYGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALADLPEWY-GIKGMQAHWIGDCVGCHLDFTLkvdgEDTGEKLT 296
Cdd:TIGR00396 166 QVDSDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPeSVKEMQRNWIGKSEGVEITFKI----ADHDEKIT 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   297 AYTATPEAIYGISHVAISPSHGLL-HGCSS-------VKKALQK-------ALVPGRDCLTPVMAVSMLTLQEVPIVImA 361
Cdd:TIGR00396 242 VFTTRPDTIFGVTYLALAPEHPLVeKAAENnpkvaafIKKILNKtvaertkATKEKKGVDTGIKAIHPLTGEKIPIWV-A 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   362 NPDLEG-SLDSKIGIPSTSSEDTRLAQALGLPYSEVIEASPD---------GTERLSGSAEFTGMTRQDAFVALTRKARG 431
Cdd:TIGR00396 321 NYVLMEyGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKdlsltaaytEDGVLVNSGEFNGLNSSEARNAIIDMLEK 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   432 MRVGGHVTSNKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLPVILPSIASLTGRGGSPLATALEWVNCSCPRCKGS 511
Cdd:TIGR00396 401 EGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNVTCPSCGKP 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   512 AKRETDTMDTFVDSAWYYFRYTDPHNTQSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHK 591
Cdd:TIGR00396 481 ALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPFKK 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   592 LLAQGLIKGQTFRlPSGQcLKKEDIDFTGPAPVCAKTKEKLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPP 671
Cdd:TIGR00396 561 LINQGMVLGFYYP-PNGK-VPADVLTERDEKGKDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPI 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   672 EKDILWDvkTDALPGVLRWQQRLWSLTTRFIEArtsgtvPQPQLLNSKEKTKAQNLWEYK-NAVIAQVTTHFTEDFALNS 750
Cdd:TIGR00396 639 AASLEWN--ESGLEGARRFLDRVWNLVYEITGE------LDAASLTVTALEEAQKELRRDvHKFLKKVTEDLEKRESFNT 710
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   751 VVSQLMGLSSALSQASQRVVLhspefEDALCALLVMAAPLAPHVTSELWAGLTLVPSklcdhyAWDSgvmlQAWPTVDSQ 830
Cdd:TIGR00396 711 AISAMMELLNKLYKAKKEALM-----LEYLKGFVTVLSPFAPHLAEELWEKLGSEPF------IIDN----AKWPVVDET 775
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   831 FLQKpDMVQMAVLINNKACGKIPVPQHVaqDQDKVHELVLQSELGMKLLQGRSIKKAFLSPrTALINFLV 900
Cdd:TIGR00396 776 ALVE-DKTLIVVQVNGKFRAKITVPKDA--DEEQVEELAKQDPEVKKYLENKTIKKVIYVP-GKLVNFVI 841
 
Name Accession Description Interval E-value
leuS_bact TIGR00396
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ...
58-900 0e+00

leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273057 [Multi-domain]  Cd Length: 842  Bit Score: 847.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    58 VEKWWHQQIKEQASRVSEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENA 137
Cdd:TIGR00396   6 IEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLPAENA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   138 AIERNLHPESWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANE 217
Cdd:TIGR00396  86 AIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGTVLANE 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   218 QVNEYGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALADLPEWY-GIKGMQAHWIGDCVGCHLDFTLkvdgEDTGEKLT 296
Cdd:TIGR00396 166 QVDSDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPeSVKEMQRNWIGKSEGVEITFKI----ADHDEKIT 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   297 AYTATPEAIYGISHVAISPSHGLL-HGCSS-------VKKALQK-------ALVPGRDCLTPVMAVSMLTLQEVPIVImA 361
Cdd:TIGR00396 242 VFTTRPDTIFGVTYLALAPEHPLVeKAAENnpkvaafIKKILNKtvaertkATKEKKGVDTGIKAIHPLTGEKIPIWV-A 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   362 NPDLEG-SLDSKIGIPSTSSEDTRLAQALGLPYSEVIEASPD---------GTERLSGSAEFTGMTRQDAFVALTRKARG 431
Cdd:TIGR00396 321 NYVLMEyGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKdlsltaaytEDGVLVNSGEFNGLNSSEARNAIIDMLEK 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   432 MRVGGHVTSNKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLPVILPSIASLTGRGGSPLATALEWVNCSCPRCKGS 511
Cdd:TIGR00396 401 EGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNVTCPSCGKP 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   512 AKRETDTMDTFVDSAWYYFRYTDPHNTQSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHK 591
Cdd:TIGR00396 481 ALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPFKK 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   592 LLAQGLIKGQTFRlPSGQcLKKEDIDFTGPAPVCAKTKEKLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPP 671
Cdd:TIGR00396 561 LINQGMVLGFYYP-PNGK-VPADVLTERDEKGKDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPI 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   672 EKDILWDvkTDALPGVLRWQQRLWSLTTRFIEArtsgtvPQPQLLNSKEKTKAQNLWEYK-NAVIAQVTTHFTEDFALNS 750
Cdd:TIGR00396 639 AASLEWN--ESGLEGARRFLDRVWNLVYEITGE------LDAASLTVTALEEAQKELRRDvHKFLKKVTEDLEKRESFNT 710
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   751 VVSQLMGLSSALSQASQRVVLhspefEDALCALLVMAAPLAPHVTSELWAGLTLVPSklcdhyAWDSgvmlQAWPTVDSQ 830
Cdd:TIGR00396 711 AISAMMELLNKLYKAKKEALM-----LEYLKGFVTVLSPFAPHLAEELWEKLGSEPF------IIDN----AKWPVVDET 775
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   831 FLQKpDMVQMAVLINNKACGKIPVPQHVaqDQDKVHELVLQSELGMKLLQGRSIKKAFLSPrTALINFLV 900
Cdd:TIGR00396 776 ALVE-DKTLIVVQVNGKFRAKITVPKDA--DEEQVEELAKQDPEVKKYLENKTIKKVIYVP-GKLVNFVI 841
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
59-900 0e+00

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 223569 [Multi-domain]  Cd Length: 814  Bit Score: 744.49  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  59 EKWwhQQI--KEQASRVSEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAEN 136
Cdd:COG0495  12 EKW--QKRweEAKVFEADEDSDKPEKFYVLVMFPYPSGALHVGHVRNYTIGDVIARYKRMQGYNVLHPMGWDAFGLPAEN 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 137 AAIERNLHPESWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLAN 216
Cdd:COG0495  90 AAIKIGTDPAKWTYYNIAYMKKQLKSLGFSIDWRREFATCDPEYYKWIQWQFLKLYEKGLAYRKEAPVNWCPVDGTVLAN 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 217 EQVnEYGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALADL----PEwyGIKGMQAHWIGDCVGchLDFTLKVDGEDTG 292
Cdd:COG0495 170 EQV-IDGGCWRCGEPVEIKELTQWFFKITDYADELLDDLDKLatlwPE--TVKGMQRNWIGPSEG--YEVAFVVDGEEEI 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 293 EKLTAYTATPEAIYGISHVAISPSHGLLHGCSS----------VKKALQKALV-------PGRDCLTPVMAVSMLTLQEV 355
Cdd:COG0495 245 VSIEVFTTRPDTLFGVTYVVLAPEHPLVGKLVTnpqtplvaefVDECKGTGVVesvpahaEKDGVFLGGYAINPVNGEKI 324
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 356 PIVImANPDLEGS-LDSKIGIPSTSSEDTRLAQALGLPYSEVI-------EASPDGTERLSGSAEFTGMTRQDAFVALTR 427
Cdd:COG0495 325 PVWI-ANYVLMEYgTGAVMGVPAHDERDLEFATKYKLPIKKVImpegtvgKKVYEGEGVLINSGGLDGLDYEEAKVKIRC 403
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 428 KARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLPVILPSIASLTGrGGSPLATALEWVNCSCPr 507
Cdd:COG0495 404 GLVKRGLGQWFVNYRLRDWLKSRQRYWGEPIPIIHCEDCGVVPVPEDWLPVKLPERVRGLG-TGSPLPWDEEWVIESLP- 481
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 508 cKGSAKRETDTMDTFVDSAWYYFRYTDPHNTQ-SPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHR 586
Cdd:COG0495 482 -DSTAYRETDTMDTFIDSSWYYLRFFDPIFLGeLPFDREEFNYWYPVDLYIGGIEHAVLHLLYFRFFHKALFDEGLVPKD 560
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 587 EPFHKLLAQGLIkgqtfrlpsgqcLKKEDidftgpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYIL 666
Cdd:COG0495 561 EPFKKLITQGMV------------LGEEG---------------------EKMSKSKGNVVDPEEAVEKYGADTVRLYIM 607
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 667 FAAPPEKDILWDvkTDALPGVLRWQQRLWSLTTRFIEartsgtvpqpqlLNSKEKTKAQNL---WEYkNAVIAQVTTHFT 743
Cdd:COG0495 608 FAAPPEQDLEWS--ESGVEGARRFLQRVWNLVKEHLE------------KLVEELTKEQGKedrWLL-HRTIKKVTEDFE 672
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 744 EDFALNSVVSQLMGLSSALSQASQRVVLHSPEFEDALCALLVMAAPLAPHVTSELWAGLTLvpsklcdhyawDSGVMLQA 823
Cdd:COG0495 673 ARQTFNTAIAALMELLNALRKYLRRTEGDRKVLREALETWVRLLAPFAPHIAEELWEELGN-----------EGFVSNAP 741
                       810       820       830       840       850       860       870
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23346617 824 WPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQDKVHELVLQSELGMKLLQGRSIKKAFLSPRTaLINFLV 900
Cdd:COG0495 742 WPEPDEEAL-VEDEVEIVVQVNGKVRAREVVA--ADADEEKVKEIALADEEVQKFLQGKTIKKVIAVPGK-PVNIVE 814
PLN02563 PLN02563
aminoacyl-tRNA ligase
2-891 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 583.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    2 ASTCQRLSFYVSPLKRQLVSRPpvilWERlIPGCSRSiySATGKWTKEYTLQTR----KDVEKWWHQQIKE-QASRVSEE 76
Cdd:PLN02563  32 AQTPASASSYFRRSRRGGVSRS----LTR-RAFAAPS--ALTSTTAKTTPAAKRaypfHEIEPKWQRYWEEnRTFRTPDD 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   77 -DKLKPKFYLLSMFPYPSGK-LHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIK 154
Cdd:PLN02563 105 vDTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAEQYAIETGTHPKITTLKNIA 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  155 HMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVNEyGCSWRSGAKVEK 234
Cdd:PLN02563 185 RFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVVD-GLSERGGHPVIR 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  235 KYLRQWFIKTTAYAKAMQDALADLpEW-YGIKGMQAHWIGDCVGCHLDF-TLKVDGEDTGEKLTAYTATPEAIYGISHVA 312
Cdd:PLN02563 264 KPMRQWMLKITAYADRLLEDLDDL-DWpESIKEMQRNWIGRSEGAELDFsVLDGEGKERDEKITVYTTRPDTLFGATYLV 342
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  313 ISPSHGLLhgcSSVKKALQKALVPG------------RDCL--------TPVMAVSMLTLQEVPIVImANPDLeGSLDSK 372
Cdd:PLN02563 343 VAPEHPLL---SSLTTAEQKEAVEEyvdaasrksdleRTELqkektgvfTGSYAINPATGEAIPIWV-ADYVL-GSYGTG 417
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  373 --IGIPSTSSEDTRLAQALGLPYSEVIeASPDGTERLSGSA---------------EFTGMTRQDAFVALTRKARGMRVG 435
Cdd:PLN02563 418 aiMAVPAHDTRDFEFAQKFDLPIKWVV-KPADGNEDDAEKAytgegvivnssssglDINGLSSKEAAKKVIEWLEETGNG 496
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  436 GHVTSNKLKDWLISRQRYWGTPIPIVHCPACG-PVPVPLQDLPVILPSIASLT--GRGGSPLATALEWVNCSCPRCKGSA 512
Cdd:PLN02563 497 KKKVNYKLRDWLFARQRYWGEPIPVVFLEDSGePVPVPESDLPLTLPELDDFTptGTGEPPLAKAVSWVNTVDPSSGKPA 576
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  513 KRETDTMDTFVDSAWYYFRYTDPHNTQSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKL 592
Cdd:PLN02563 577 RRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWHKVLYDIGVVSTKEPFQCL 656
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  593 LAQGLIKGQ----TFRLPSGQ----------------CLKKEDIDFTGPAPVcAKTKEKLEVTWE--KMSKSKHNGVDPE 650
Cdd:PLN02563 657 VNQGMILGEveytAFKDSDGEyvsadtadrlgelqqeKIPEEKVIKSGDSFV-LKDDPSIRLIARahKMSKSRGNVVNPD 735
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  651 EIVAQYGIDTIRLYILFAAPPEKDILWdvKTDALPGVLRWQQRLWSLTTRfiEARTSGTVPQPQLLNSKEKTKAQNLWEY 730
Cdd:PLN02563 736 DVVSEYGADSLRLYEMFMGPLRDSKTW--STSGVEGVHRFLGRTWRLVVG--APLPDGSFRDGTVVTDEEPSLEQLRLLH 811
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  731 KnaVIAQVTTHfTEDFALNSVVSQLMGLSSALSQASQRVVlhspefeDALCALLVMAAPLAPHVTSELWagltlvpsKLC 810
Cdd:PLN02563 812 K--CIAKVTEE-IESTRFNTAISAMMEFTNAAYKWDKVPR-------EAIEPFVLLLSPYAPHLAEELW--------FRL 873
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  811 DHyawDSGVMLQAWPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQDKVHELVLQSELGMKLLQGRSIKKAFLS 890
Cdd:PLN02563 874 GH---SNSLAYEPWPEANPSYL-VDDTVVLPVQINGKTRGTIEVE--EGCSEDDAFALASQDEKLSKYLDGKEIKKRIYV 947

                 .
gi 23346617  891 P 891
Cdd:PLN02563 948 P 948
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
82-677 2.90e-131

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 396.23  E-value: 2.90e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  82 KFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKHMRKQLD 161
Cdd:cd00812   1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 162 RLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDpvdqtvlaneqvneygcswrsgakvekKYLRQWF 241
Cdd:cd00812  81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC---------------------------KLLDQWF 133
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 242 IKT--TAYAKAMQDALADLPEWY-GIKGMQAHWIGdcvgchldftlkvdgedtgekltaytatpeaiygishvaispshg 318
Cdd:cd00812 134 LKYseTEWKEKLLKDLEKLDGWPeEVRAMQENWIG--------------------------------------------- 168
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 319 llhgcssvkkalqkalvpgrdcltpvmavsmltlqevpivimanpdlegsldskigipstssedtrlaqalglpysevie 398
Cdd:cd00812     --------------------------------------------------------------------------------
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 399 aspdgterlsgsaeftgmtrqdafvaltrkargmrvgghvtsnklkdwlISRQRYWGTPIPIvhcpacgpvpvplqdlpv 478
Cdd:cd00812 169 -------------------------------------------------CSRQRYWGTPIPW------------------ 181
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 479 ilpsiasltgrggsplatalewvncscprckgsakreTDTMDTFVDSAWYYFRYTDPHNTQSP------FGSALADFWMP 552
Cdd:cd00812 182 -------------------------------------TDTMESLSDSTWYYARYTDAHNLEQPyegdleFDREEFEYWYP 224
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 553 VDLYIGGKEHAVMHLFYARFLSHFCHDQKMVkHREPFHKLLAQGLIKGQTfrlpsgqclkkedidftgpapvcaktkekl 632
Cdd:cd00812 225 VDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVLLEG------------------------------ 273
                       570       580       590       600
                ....*....|....*....|....*....|....*....|....*
gi 23346617 633 evtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 677
Cdd:cd00812 274 ----EKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
60-678 5.80e-34

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 395082 [Multi-domain]  Cd Length: 603  Bit Score: 138.70  E-value: 5.80e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    60 KWWHQQIKEQASRvsEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAEnAAI 139
Cdd:pfam00133   4 EFWDEIGYFKPEL--EKRKGKPSFTLHDGPPNATGSLHMGHALAKTLKDIVIRYKRMQGYYVLWVPGWDHHGLPIE-QVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   140 ERNLHPE------------------SWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKE 201
Cdd:pfam00133  81 EKKLGIKegkdrhkygreefrekcrEWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   202 ALVNWDPVDQTVLANEQVnEYgcswrsgakvekkylrqwfikttayaKAMQDALAdlpewygikgmqahwigdcvgcHLD 281
Cdd:pfam00133 161 KPVNWSPALNTALSNAEV-EY--------------------------KDVKGPSI----------------------HVA 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   282 FTLKvDGEDTgeKLTAYTATPEAIYGISHVAISP-------SHGLLHGCSSVKKALQKALVPGRDCLTP-------VMAV 347
Cdd:pfam00133 192 FPLA-DDKDA--SLVIWTTTPWTLPGNTAIAVNPefdyvitGEGLILAEALLKSLYKKEKTDYKILEDFrgkelegKEAI 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   348 SMLTLQEVPIVIMANPDLE-GSLDSKIGiPSTSSEDTRLAQALGLPYSEVIEASPDGTErlsGSAEFTGMTRQDAFVALT 426
Cdd:pfam00133 269 HPFVNREIPIITDDYVDMDfGTGAVHTA-PAHGEDDYEVGQRHNLEVINPVDDDGTFTE---EAPDFQGMYRFDARKKVV 344
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   427 R--KARGMRVggHVTSNKLK--------------------------------------------------------DWLI 448
Cdd:pfam00133 345 EllTEKGLLL--KIEPFTHSypfcwrsgtpiipratpqwfvrmdelrddaleavekvqfvpksgekryfnwlrniqDWCI 422
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   449 SRQRYWGTPIPIVHCPACGPVpVPLQDLPVIlpsIASLTGRGGSPLATALEWVNCScPRCKGSAKRETDTMDTFVDSA-W 527
Cdd:pfam00133 423 SRQRWWGHPIPAWYSEDTEEV-VCRGELVEL---VAGRFEEEGSIKWLHREAKDKS-GSGKGTLEQDEDVLDTWFSSGsW 497
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   528 YYFRYTDPHNTQSPFgsalaDFWMPVDLYIGGKEhavMHLFYarFLSHFCHDQKMVKhREPFHKLLAQGLIkgqtfRLPS 607
Cdd:pfam00133 498 PFSVLGWPFENTEEF-----KKFFPADMLLEGSD---QTRGW--FYRMIMLSTALTG-SVPYKNVLVHGLV-----RDEQ 561
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23346617   608 GQclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFaAPPEKDILWD 678
Cdd:pfam00133 562 GR----------------------------KMSKSLGNVIDPLDVIDKYGADALRLWLAN-SDYGRDINLS 603
 
Name Accession Description Interval E-value
leuS_bact TIGR00396
leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases ...
58-900 0e+00

leucyl-tRNA synthetase, eubacterial and mitochondrial family; The leucyl-tRNA synthetases belong to two families so broadly different that they are represented by separate models. This model includes both eubacterial and mitochondrial leucyl-tRNA synthetases. It generates higher scores for some valyl-tRNA synthetases than for any archaeal or eukaryotic cytosolic leucyl-tRNA synthetase. Note that the enzyme from Aquifex aeolicus is split into alpha and beta chains; neither chain is long enough to score above the trusted cutoff, but the alpha chain scores well above the noise cutoff. The beta chain must be found by a model and search designed for partial length matches. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273057 [Multi-domain]  Cd Length: 842  Bit Score: 847.50  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    58 VEKWWHQQIKEQASRVSEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENA 137
Cdd:TIGR00396   6 IEEKWQQKWDENKTFKVTDDSSKPKYYILSMFPYPSGALHMGHVRNYTITDVLSRYYRMKGYNVLHPIGWDAFGLPAENA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   138 AIERNLHPESWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANE 217
Cdd:TIGR00396  86 AIKRGIHPAKWTYENIANMKKQLQALGFSYDWDREIATCDPEYYKWTQWIFLELFEKGLAYVKEADVNWCPNDGTVLANE 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   218 QVNEYGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALADLPEWY-GIKGMQAHWIGDCVGCHLDFTLkvdgEDTGEKLT 296
Cdd:TIGR00396 166 QVDSDGRSWRGDTPVEKKELKQWFLKITAYAEELLNDLEELDHWPeSVKEMQRNWIGKSEGVEITFKI----ADHDEKIT 241
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   297 AYTATPEAIYGISHVAISPSHGLL-HGCSS-------VKKALQK-------ALVPGRDCLTPVMAVSMLTLQEVPIVImA 361
Cdd:TIGR00396 242 VFTTRPDTIFGVTYLALAPEHPLVeKAAENnpkvaafIKKILNKtvaertkATKEKKGVDTGIKAIHPLTGEKIPIWV-A 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   362 NPDLEG-SLDSKIGIPSTSSEDTRLAQALGLPYSEVIEASPD---------GTERLSGSAEFTGMTRQDAFVALTRKARG 431
Cdd:TIGR00396 321 NYVLMEyGTGAVMGVPAHDERDFEFAQKYGLPIKPVIDPAEKdlsltaaytEDGVLVNSGEFNGLNSSEARNAIIDMLEK 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   432 MRVGGHVTSNKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLPVILPSIASLTGRGGSPLATALEWVNCSCPRCKGS 511
Cdd:TIGR00396 401 EGKGKRKVNYRLRDWGFSRQRYWGEPIPIIHCEDGGVVPVPEEDLPVILPEDVVYDGDGGSPLSRIPEWVNVTCPSCGKP 480
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   512 AKRETDTMDTFVDSAWYYFRYTDPHNTQSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHK 591
Cdd:TIGR00396 481 ALRETDTMDTFAGSSWYYLRYLDPKNTDGPFDKEKAEYWLPVDLYIGGIEHAILHLLYARFFHKFLRDIGYVNTKEPFKK 560
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   592 LLAQGLIKGQTFRlPSGQcLKKEDIDFTGPAPVCAKTKEKLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPP 671
Cdd:TIGR00396 561 LINQGMVLGFYYP-PNGK-VPADVLTERDEKGKDKAGGELVYVGYEKMSKSKGNGIDPQEIVESYGADALRLFIMFMGPI 638
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   672 EKDILWDvkTDALPGVLRWQQRLWSLTTRFIEArtsgtvPQPQLLNSKEKTKAQNLWEYK-NAVIAQVTTHFTEDFALNS 750
Cdd:TIGR00396 639 AASLEWN--ESGLEGARRFLDRVWNLVYEITGE------LDAASLTVTALEEAQKELRRDvHKFLKKVTEDLEKRESFNT 710
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   751 VVSQLMGLSSALSQASQRVVLhspefEDALCALLVMAAPLAPHVTSELWAGLTLVPSklcdhyAWDSgvmlQAWPTVDSQ 830
Cdd:TIGR00396 711 AISAMMELLNKLYKAKKEALM-----LEYLKGFVTVLSPFAPHLAEELWEKLGSEPF------IIDN----AKWPVVDET 775
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   831 FLQKpDMVQMAVLINNKACGKIPVPQHVaqDQDKVHELVLQSELGMKLLQGRSIKKAFLSPrTALINFLV 900
Cdd:TIGR00396 776 ALVE-DKTLIVVQVNGKFRAKITVPKDA--DEEQVEELAKQDPEVKKYLENKTIKKVIYVP-GKLVNFVI 841
LeuS COG0495
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
59-900 0e+00

Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 223569 [Multi-domain]  Cd Length: 814  Bit Score: 744.49  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  59 EKWwhQQI--KEQASRVSEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAEN 136
Cdd:COG0495  12 EKW--QKRweEAKVFEADEDSDKPEKFYVLVMFPYPSGALHVGHVRNYTIGDVIARYKRMQGYNVLHPMGWDAFGLPAEN 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 137 AAIERNLHPESWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLAN 216
Cdd:COG0495  90 AAIKIGTDPAKWTYYNIAYMKKQLKSLGFSIDWRREFATCDPEYYKWIQWQFLKLYEKGLAYRKEAPVNWCPVDGTVLAN 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 217 EQVnEYGCSWRSGAKVEKKYLRQWFIKTTAYAKAMQDALADL----PEwyGIKGMQAHWIGDCVGchLDFTLKVDGEDTG 292
Cdd:COG0495 170 EQV-IDGGCWRCGEPVEIKELTQWFFKITDYADELLDDLDKLatlwPE--TVKGMQRNWIGPSEG--YEVAFVVDGEEEI 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 293 EKLTAYTATPEAIYGISHVAISPSHGLLHGCSS----------VKKALQKALV-------PGRDCLTPVMAVSMLTLQEV 355
Cdd:COG0495 245 VSIEVFTTRPDTLFGVTYVVLAPEHPLVGKLVTnpqtplvaefVDECKGTGVVesvpahaEKDGVFLGGYAINPVNGEKI 324
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 356 PIVImANPDLEGS-LDSKIGIPSTSSEDTRLAQALGLPYSEVI-------EASPDGTERLSGSAEFTGMTRQDAFVALTR 427
Cdd:COG0495 325 PVWI-ANYVLMEYgTGAVMGVPAHDERDLEFATKYKLPIKKVImpegtvgKKVYEGEGVLINSGGLDGLDYEEAKVKIRC 403
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 428 KARGMRVGGHVTSNKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLPVILPSIASLTGrGGSPLATALEWVNCSCPr 507
Cdd:COG0495 404 GLVKRGLGQWFVNYRLRDWLKSRQRYWGEPIPIIHCEDCGVVPVPEDWLPVKLPERVRGLG-TGSPLPWDEEWVIESLP- 481
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 508 cKGSAKRETDTMDTFVDSAWYYFRYTDPHNTQ-SPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHR 586
Cdd:COG0495 482 -DSTAYRETDTMDTFIDSSWYYLRFFDPIFLGeLPFDREEFNYWYPVDLYIGGIEHAVLHLLYFRFFHKALFDEGLVPKD 560
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 587 EPFHKLLAQGLIkgqtfrlpsgqcLKKEDidftgpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYIL 666
Cdd:COG0495 561 EPFKKLITQGMV------------LGEEG---------------------EKMSKSKGNVVDPEEAVEKYGADTVRLYIM 607
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 667 FAAPPEKDILWDvkTDALPGVLRWQQRLWSLTTRFIEartsgtvpqpqlLNSKEKTKAQNL---WEYkNAVIAQVTTHFT 743
Cdd:COG0495 608 FAAPPEQDLEWS--ESGVEGARRFLQRVWNLVKEHLE------------KLVEELTKEQGKedrWLL-HRTIKKVTEDFE 672
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 744 EDFALNSVVSQLMGLSSALSQASQRVVLHSPEFEDALCALLVMAAPLAPHVTSELWAGLTLvpsklcdhyawDSGVMLQA 823
Cdd:COG0495 673 ARQTFNTAIAALMELLNALRKYLRRTEGDRKVLREALETWVRLLAPFAPHIAEELWEELGN-----------EGFVSNAP 741
                       810       820       830       840       850       860       870
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 23346617 824 WPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQDKVHELVLQSELGMKLLQGRSIKKAFLSPRTaLINFLV 900
Cdd:COG0495 742 WPEPDEEAL-VEDEVEIVVQVNGKVRAREVVA--ADADEEKVKEIALADEEVQKFLQGKTIKKVIAVPGK-PVNIVE 814
PLN02563 PLN02563
aminoacyl-tRNA ligase
2-891 0e+00

aminoacyl-tRNA ligase


Pssm-ID: 178177 [Multi-domain]  Cd Length: 963  Bit Score: 583.32  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    2 ASTCQRLSFYVSPLKRQLVSRPpvilWERlIPGCSRSiySATGKWTKEYTLQTR----KDVEKWWHQQIKE-QASRVSEE 76
Cdd:PLN02563  32 AQTPASASSYFRRSRRGGVSRS----LTR-RAFAAPS--ALTSTTAKTTPAAKRaypfHEIEPKWQRYWEEnRTFRTPDD 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   77 -DKLKPKFYLLSMFPYPSGK-LHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIK 154
Cdd:PLN02563 105 vDTSKPKFYVLDMFPYPSGAgLHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGLPAEQYAIETGTHPKITTLKNIA 184
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  155 HMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVNEyGCSWRSGAKVEK 234
Cdd:PLN02563 185 RFRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRGLAYQAEVPVNWCPALGTVLANEEVVD-GLSERGGHPVIR 263
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  235 KYLRQWFIKTTAYAKAMQDALADLpEW-YGIKGMQAHWIGDCVGCHLDF-TLKVDGEDTGEKLTAYTATPEAIYGISHVA 312
Cdd:PLN02563 264 KPMRQWMLKITAYADRLLEDLDDL-DWpESIKEMQRNWIGRSEGAELDFsVLDGEGKERDEKITVYTTRPDTLFGATYLV 342
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  313 ISPSHGLLhgcSSVKKALQKALVPG------------RDCL--------TPVMAVSMLTLQEVPIVImANPDLeGSLDSK 372
Cdd:PLN02563 343 VAPEHPLL---SSLTTAEQKEAVEEyvdaasrksdleRTELqkektgvfTGSYAINPATGEAIPIWV-ADYVL-GSYGTG 417
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  373 --IGIPSTSSEDTRLAQALGLPYSEVIeASPDGTERLSGSA---------------EFTGMTRQDAFVALTRKARGMRVG 435
Cdd:PLN02563 418 aiMAVPAHDTRDFEFAQKFDLPIKWVV-KPADGNEDDAEKAytgegvivnssssglDINGLSSKEAAKKVIEWLEETGNG 496
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  436 GHVTSNKLKDWLISRQRYWGTPIPIVHCPACG-PVPVPLQDLPVILPSIASLT--GRGGSPLATALEWVNCSCPRCKGSA 512
Cdd:PLN02563 497 KKKVNYKLRDWLFARQRYWGEPIPVVFLEDSGePVPVPESDLPLTLPELDDFTptGTGEPPLAKAVSWVNTVDPSSGKPA 576
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  513 KRETDTMDTFVDSAWYYFRYTDPHNTQSPFGSALADFWMPVDLYIGGKEHAVMHLFYARFLSHFCHDQKMVKHREPFHKL 592
Cdd:PLN02563 577 RRETNTMPQWAGSCWYYLRFMDPKNSNALVDKEKEKYWMPVDLYVGGAEHAVLHLLYARFWHKVLYDIGVVSTKEPFQCL 656
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  593 LAQGLIKGQ----TFRLPSGQ----------------CLKKEDIDFTGPAPVcAKTKEKLEVTWE--KMSKSKHNGVDPE 650
Cdd:PLN02563 657 VNQGMILGEveytAFKDSDGEyvsadtadrlgelqqeKIPEEKVIKSGDSFV-LKDDPSIRLIARahKMSKSRGNVVNPD 735
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  651 EIVAQYGIDTIRLYILFAAPPEKDILWdvKTDALPGVLRWQQRLWSLTTRfiEARTSGTVPQPQLLNSKEKTKAQNLWEY 730
Cdd:PLN02563 736 DVVSEYGADSLRLYEMFMGPLRDSKTW--STSGVEGVHRFLGRTWRLVVG--APLPDGSFRDGTVVTDEEPSLEQLRLLH 811
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  731 KnaVIAQVTTHfTEDFALNSVVSQLMGLSSALSQASQRVVlhspefeDALCALLVMAAPLAPHVTSELWagltlvpsKLC 810
Cdd:PLN02563 812 K--CIAKVTEE-IESTRFNTAISAMMEFTNAAYKWDKVPR-------EAIEPFVLLLSPYAPHLAEELW--------FRL 873
                        890       900       910       920       930       940       950       960
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  811 DHyawDSGVMLQAWPTVDSQFLqKPDMVQMAVLINNKACGKIPVPqhVAQDQDKVHELVLQSELGMKLLQGRSIKKAFLS 890
Cdd:PLN02563 874 GH---SNSLAYEPWPEANPSYL-VDDTVVLPVQINGKTRGTIEVE--EGCSEDDAFALASQDEKLSKYLDGKEIKKRIYV 947

                 .
gi 23346617  891 P 891
Cdd:PLN02563 948 P 948
LeuRS_core cd00812
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ...
82-677 2.90e-131

catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173906 [Multi-domain]  Cd Length: 314  Bit Score: 396.23  E-value: 2.90e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  82 KFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKHMRKQLD 161
Cdd:cd00812   1 KFYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFDAFGLPAENAAIKIGRDPEDWTEYNIKKMKEQLK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 162 RLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDpvdqtvlaneqvneygcswrsgakvekKYLRQWF 241
Cdd:cd00812  81 RMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC---------------------------KLLDQWF 133
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 242 IKT--TAYAKAMQDALADLPEWY-GIKGMQAHWIGdcvgchldftlkvdgedtgekltaytatpeaiygishvaispshg 318
Cdd:cd00812 134 LKYseTEWKEKLLKDLEKLDGWPeEVRAMQENWIG--------------------------------------------- 168
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 319 llhgcssvkkalqkalvpgrdcltpvmavsmltlqevpivimanpdlegsldskigipstssedtrlaqalglpysevie 398
Cdd:cd00812     --------------------------------------------------------------------------------
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 399 aspdgterlsgsaeftgmtrqdafvaltrkargmrvgghvtsnklkdwlISRQRYWGTPIPIvhcpacgpvpvplqdlpv 478
Cdd:cd00812 169 -------------------------------------------------CSRQRYWGTPIPW------------------ 181
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 479 ilpsiasltgrggsplatalewvncscprckgsakreTDTMDTFVDSAWYYFRYTDPHNTQSP------FGSALADFWMP 552
Cdd:cd00812 182 -------------------------------------TDTMESLSDSTWYYARYTDAHNLEQPyegdleFDREEFEYWYP 224
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 553 VDLYIGGKEHAVMHLFYARFLSHFCHDQKMVkHREPFHKLLAQGLIKGQTfrlpsgqclkkedidftgpapvcaktkekl 632
Cdd:cd00812 225 VDIYIGGKEHAPNHLLYSRFNHKALFDEGLV-TDEPPKGLIVQGMVLLEG------------------------------ 273
                       570       580       590       600
                ....*....|....*....|....*....|....*....|....*
gi 23346617 633 evtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 677
Cdd:cd00812 274 ----EKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADFDW 314
ValS COG0525
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
56-845 2.92e-70

Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 223599 [Multi-domain]  Cd Length: 877  Bit Score: 249.86  E-value: 2.92e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  56 KDVEKWWHQQ-IKEQASRVSEEDKlKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPA 134
Cdd:COG0525   8 KEIEEKWYKKwEESGYFKPDPNED-KPPFSIDTPPPNVTGSLHMGHALNYTLQDILARYKRMRGYNVLWPPGTDHAGIAT 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 135 ENAaIERNLHPE-----------------SWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLA 197
Cdd:COG0525  87 QVV-VEKQLAAEgitrhdlgreeflkkcwEWKEESGGTIREQLRRLGVSVDWSRERFTMDPGLSRAVQEAFVRLYEKGLI 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 198 YQKEALVNWDPVDQTVLANEQVnEYgcswrsgaKVEKKYLrqWFIKttayakamqdaladlpewYGIkgmqahwigdcvg 277
Cdd:COG0525 166 YRGERLVNWCPKCRTAISDIEV-EY--------KEVEGKL--YYIK------------------YPL------------- 203
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 278 chldftlkvdgEDTGEKLTAYTATPEAIYGISHVAISP-----SHglLHGcssvkkalQKALVPgrdcltpvmavsmLTL 352
Cdd:COG0525 204 -----------ADGDGYLVVATTRPETLLGDTAVAVHPdderyKH--LVG--------KEVILP-------------LVG 249
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 353 QEVPIVimANPDLEGSLDS---KIgIPSTSSEDTRLAQALGLPYSEVIEasPDGTERLSGSAEFTGMTRQDA-------- 421
Cdd:COG0525 250 REIPII--ADEYVDPEFGTgavKI-TPAHDFNDYEVGKRHNLPLINIID--EDGRINEEAAGEFAGLDRFEArkkivedl 324
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 422 ----------------------------------FV---ALTRKARGMRVGGHVT-------------SNKLKDWLISRQ 451
Cdd:COG0525 325 eeqgllvkiephkhsvghcercgtpiepllskqwFVkvlELAKKALEAVKDGKIKfvpermekryedwMENIRDWCISRQ 404
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 452 RYWGTPIPIVHCPACGPVPVPlQDLPVILpsiasltgrggsplataleWVNCSCPrcKGSAKRETDTMDTFVDSAWYYFr 531
Cdd:COG0525 405 LWWGHRIPVWYCKECGNVVVA-EEEPEDP-------------------AAAEKCP--KEELEQDEDVLDTWFSSSLWPF- 461
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 532 YTDPHNTQSPFgsaLADFWmPVDLYIGGkeHAVMH--LFYARFLS-HFCHDqkmvkhrEPFHKLLAQGLIKGqtfrlPSG 608
Cdd:COG0525 462 STLGWPEETPD---LKKFY-PTDLLVTG--HDIIFfwVARMIMRGlHLTGE-------VPFKDVYIHGLVRD-----EQG 523
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 609 qclkkedidftgpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDvkTDALPGVL 688
Cdd:COG0525 524 ----------------------------RKMSKSKGNVIDPLDVIDKYGADALRFTLASLASPGRDINFD--EKRVEGYR 573
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 689 RWQQRLWSLtTRFIEARTSGTVPQPQLLNSKEKTkaqNLWEYK--NAVIAQVTTHFtEDFALNSVVSQLMGL-------- 758
Cdd:COG0525 574 NFLNKLWNA-TRFVLMNLDDLGPDDLDLLALSLA---DRWILSrlNETVKEVTEAL-DNYRFDEAARALYEFiwndfcdw 648
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 759 ----------SSALSQASQRVVLHSpefedALCALLVMAAPLAPHVTSELWAGLTLVPSklcdhyawdsgVMLQAWPTVD 828
Cdd:COG0525 649 ylelakprlyGGEEEKRAARATLYY-----VLDTLLRLLHPFMPFITEEIWQKLPGTES-----------IHLASWPEVD 712
                       890
                ....*....|....*..
gi 23346617 829 SQFLQKPDMVQMAVLIN 845
Cdd:COG0525 713 EELIDEEAEKEFELLKE 729
valS PRK13208
valyl-tRNA synthetase; Reviewed
45-828 3.27e-61

valyl-tRNA synthetase; Reviewed


Pssm-ID: 237306 [Multi-domain]  Cd Length: 800  Bit Score: 222.76  E-value: 3.27e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   45 KWTKEYTLqtrKDVEKWWhqQIKEQASRV--SEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVI 122
Cdd:PRK13208   5 ELPKKYDP---EELEEKW--QKIWEEEGTykFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVF 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  123 NPMGWDAFGLPaenaaIER--------NLHPES----------WTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWT 184
Cdd:PRK13208  80 FPQGWDDNGLP-----TERkvekyygiRKDDISreefielcreLTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRIS 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  185 QYLFIKLYEAGLAYQKEALVNWDPVDQTVLANeqvneygcswrsgAKVEKKylrqwfIKTTAYAkamqdaladlpewygi 264
Cdd:PRK13208 155 QKSFLDLYKKGLIYRAEAPVLWCPRCETAIAQ-------------AEVEYR------EREGKLN---------------- 199
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  265 kgmqahwigdcvgcHLDFTLKvdgedTGEKLTAYTATPEAIYGISHVAISPS-----HglLHGcssvkkalQKALVPgrd 339
Cdd:PRK13208 200 --------------YIKFPVE-----DGEEIEIATTRPELLPACVAVVVHPDderykH--LVG--------KTAIVP--- 247
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  340 cltpvmavsmLTLQEVPivIMANPDLE---GSldskiGIPSTSS----EDTRLAQALGLPYSEVIeaSPDGteRLSGSA- 411
Cdd:PRK13208 248 ----------LFGVEVP--ILADPLVDpdfGT-----GAVMICTfgdkTDVTWWRELNLPTRIII--DEDG--RMTEAAg 306
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  412 EFTGMTRQDAfvaltRKA-------RGM---------RVGGH---------VTS------------------NKLK---- 444
Cdd:PRK13208 307 KLAGLTIEEA-----RKKivedlksGGLlgkqepikhNVKFCercdtpleiLVTrqwfikvldlkeellergKEINwype 381
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  445 ---------------DWLISRQRYWGTPIPIVHCPACG-PVPVPLQDLPVilpsiasltgrggSPLATALEWvnCSCPRC 508
Cdd:PRK13208 382 hmrvrlenwieglnwDWCISRQRYFGTPIPVWYCKDCGhPILPDEEDLPV-------------DPTKDEPPG--YKCPQC 446
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  509 -KGSAKRETDTMDTFVDS---AWYYFRYTDPHntqspfgsalaDFWM---PVDLYIGGkehavmH------LFYARFLSH 575
Cdd:PRK13208 447 gSPGFEGETDVMDTWATSsitPLIVTGWERDE-----------DLFEkvfPMDLRPQG------HdiirtwLFYTILRAY 509
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  576 FCHDQKmvkhrePFHKLlaqgLIkgqtfrlpSGQCLkKEDidftGpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQ 655
Cdd:PRK13208 510 LLTGKL------PWKNI----MI--------SGMVL-DPD----G----------------KKMSKSKGNVVTPEELLEK 550
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  656 YGIDTIRLYILfAAPPEKDILWDVKTdaLPGVLRWQQRLWSLtTRFIEARTSGTVPQPqllnsKEKTKAQNLW--EYKNA 733
Cdd:PRK13208 551 YGADAVRYWAA-SARLGSDTPFDEKQ--VKIGRRLLTKLWNA-SRFVLHFSADPEPDK-----AEVLEPLDRWilAKLAK 621
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  734 VIAQVTTHF-----------TEDFALNS--------VVSQLMGLSSALSQASQRVVLHSpefedALCALLVMAAPLAPHV 794
Cdd:PRK13208 622 VVEKATEALenydfakaleeIESFFWHVfcddylelVKSRAYGEDEEEEQKSARYTLYT-----VLDTLLRLLAPFLPFI 696
                        890       900       910
                 ....*....|....*....|....*....|....
gi 23346617  795 TSELWagltlvpsklcdHYAWDSGVMLQAWPTVD 828
Cdd:PRK13208 697 TEEVW------------SWLYGGSVHRASWPEPD 718
valS TIGR00422
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ...
56-832 1.44e-58

valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273070 [Multi-domain]  Cd Length: 861  Bit Score: 216.08  E-value: 1.44e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    56 KDVEKWWHQQIKEQASRVSEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAE 135
Cdd:TIGR00422   8 HEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTDHAGIATQ 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   136 nAAIERNLHPES-----------------WTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAY 198
Cdd:TIGR00422  88 -VKVEKKLGAEGktkhdlgreefrekiweWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLYEKGLIY 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   199 QKEALVNWDPVDQTVLANEQVnEYgcswrsgakvekkylrqwfikttayaKAMQDALadlpeWYgikgmqahwigdcvgc 278
Cdd:TIGR00422 167 RGEYLVNWDPKLNTAISDIEV-EY--------------------------KEVKGKL-----YY---------------- 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   279 hLDFTLKVDGEDtgeKLTAYTATPEAIYGISHVAISP-----SHglLHGcssvkkalQKALVPgrdcltpvmavsmLTLQ 353
Cdd:TIGR00422 199 -IRYPLANGSKD---YLVVATTRPETMFGDTAVAVHPederyKH--LIG--------KKVILP-------------LTGR 251
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   354 EVPIVIMANPDLE-GSLDSKIgIPSTSSEDTRLAQALGLPYSEVIEAspDGTERLSGsAEFTGMTRQDA----------- 421
Cdd:TIGR00422 252 KIPIIADEYVDMEfGTGAVKV-TPAHDFNDYEWGKRHNLEFINILDE--DGLLNENA-GKYQGLTRFEArkkivedlkee 327
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   422 -------------------------------FVA---LTRKARGMRVGGHVT-------------SNKLKDWLISRQRYW 454
Cdd:TIGR00422 328 gllvkiephthnvgtcwrsgtvvepllskqwFVKvekLADKALEAAEEGEIKfvpkrmekrylnwLRNIKDWCISRQLIW 407
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   455 GTPIPIVHCPACGPVPVPLQDLPVILPsiasltgrggSPLATALEWvncscprckgsaKRETDTMDTFVDSAWYYFRYTD 534
Cdd:TIGR00422 408 GHRIPVWYCKECGEVYVAKEEPLPDDK----------TNTGPSVEL------------EQDTDVLDTWFSSSLWPFSTLG 465
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   535 -PHNTqspfgSALADFWmPVDLYIGGKEHAVMHLFYARFLSHFCHDQKmvkhrePFHKLLAQGLIKGQTFRlpsgqclkk 613
Cdd:TIGR00422 466 wPDET-----KDLKKFY-PTDLLVTGYDIIFFWVARMIFRSLALTGQV------PFKEVYIHGLVRDEQGR--------- 524
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   614 edidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDVKTdaLPGVLRWQQR 693
Cdd:TIGR00422 525 ------------------------KMSKSLGNVIDPLDVIEKYGADALRFTLASLVTPGDDINFDWKR--VESARNFLNK 578
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   694 LWSlTTRFIEARTSGtvpQPQLLNSKEKTKAQNLWEYK--NAVIAQVTTHFtEDFALNSVVS------------------ 753
Cdd:TIGR00422 579 LWN-ASRFVLMNLSD---DLELSGGEEKLSLADRWILSklNRTIKEVRKAL-DKYRFAEAAKalyefiwndfcdwyielv 653
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   754 --QLMGLSSALSQASQRVVLHspefedALCALLVMAAPLAPHVTSELWAGLtlvpsklcdHYAWDSgVMLQAWPTVDSQF 831
Cdd:TIGR00422 654 kyRLYNGNEAEKKAARDTLYY------VLDKALRLLHPFMPFITEEIWQHF---------KEGADS-IMLQSYPVVDAEF 717

                  .
gi 23346617   832 L 832
Cdd:TIGR00422 718 V 718
ValRS_core cd00817
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ...
90-677 2.69e-51

catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 185677 [Multi-domain]  Cd Length: 382  Bit Score: 184.76  E-value: 2.69e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  90 PYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAEN---------AAIERNLHPE-------SWTQSNI 153
Cdd:cd00817  10 PNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVvvekklgieGKTRHDLGREeflekcwEWKEESG 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 154 KHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVneygcSWRSGAKVE 233
Cdd:cd00817  90 GKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV-----CSRSGDVIE 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 234 KKYLRQWFIKTTAYAKAMQDALAD-LPEWYGiKGMQA---HWIgdcvgchldftlkvdgedtgekltaytatpeaiygis 309
Cdd:cd00817 165 PLLKPQWFVKVKDLAKKALEAVKEgDIKFVP-ERMEKryeNWL------------------------------------- 206
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 310 hvaispshgllhgcssvkkalqkalvpgrdcltpvmavsmltlqevpivimanpdlegsldskigipstssedtrlaqal 389
Cdd:cd00817     --------------------------------------------------------------------------------
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 390 glpysevieaspdgterlsgsaeftgmtrqdafvaltrkargmrvgghvtsNKLKDWLISRQRYWGTPIPIVHCPACGPV 469
Cdd:cd00817 207 ---------------------------------------------------ENIRDWCISRQLWWGHRIPAWYCKDGGHW 235
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 470 PVPLQDLPVILPSIasltgrggsplatalewvNCSCPRCKGSA-KRETDTMDTFVDSA-WYYFRYTDPHNTQSpfgsaLA 547
Cdd:cd00817 236 VVAREEDEAIDKAA------------------PEACVPCGGEElKQDEDVLDTWFSSSlWPFSTLGWPEETKD-----LK 292
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 548 DFWmPVDLYIGGKEHAVMHLFYARFLSHFCHDQKmvkhrePFHKLLAQGLIKGqtfrlpsgqclkkEDidftgpapvcak 627
Cdd:cd00817 293 KFY-PTSLLVTGHDIIFFWVARMIMRGLKLTGKL------PFKEVYLHGLVRD-------------ED------------ 340
                       570       580       590       600       610
                ....*....|....*....|....*....|....*....|....*....|
gi 23346617 628 tkeklevtWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 677
Cdd:cd00817 341 --------GRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDINL 382
tRNA-synt_1 pfam00133
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ...
60-678 5.80e-34

tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.


Pssm-ID: 395082 [Multi-domain]  Cd Length: 603  Bit Score: 138.70  E-value: 5.80e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    60 KWWHQQIKEQASRvsEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAEnAAI 139
Cdd:pfam00133   4 EFWDEIGYFKPEL--EKRKGKPSFTLHDGPPNATGSLHMGHALAKTLKDIVIRYKRMQGYYVLWVPGWDHHGLPIE-QVV 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   140 ERNLHPE------------------SWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKE 201
Cdd:pfam00133  81 EKKLGIKegkdrhkygreefrekcrEWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   202 ALVNWDPVDQTVLANEQVnEYgcswrsgakvekkylrqwfikttayaKAMQDALAdlpewygikgmqahwigdcvgcHLD 281
Cdd:pfam00133 161 KPVNWSPALNTALSNAEV-EY--------------------------KDVKGPSI----------------------HVA 191
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   282 FTLKvDGEDTgeKLTAYTATPEAIYGISHVAISP-------SHGLLHGCSSVKKALQKALVPGRDCLTP-------VMAV 347
Cdd:pfam00133 192 FPLA-DDKDA--SLVIWTTTPWTLPGNTAIAVNPefdyvitGEGLILAEALLKSLYKKEKTDYKILEDFrgkelegKEAI 268
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   348 SMLTLQEVPIVIMANPDLE-GSLDSKIGiPSTSSEDTRLAQALGLPYSEVIEASPDGTErlsGSAEFTGMTRQDAFVALT 426
Cdd:pfam00133 269 HPFVNREIPIITDDYVDMDfGTGAVHTA-PAHGEDDYEVGQRHNLEVINPVDDDGTFTE---EAPDFQGMYRFDARKKVV 344
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   427 R--KARGMRVggHVTSNKLK--------------------------------------------------------DWLI 448
Cdd:pfam00133 345 EllTEKGLLL--KIEPFTHSypfcwrsgtpiipratpqwfvrmdelrddaleavekvqfvpksgekryfnwlrniqDWCI 422
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   449 SRQRYWGTPIPIVHCPACGPVpVPLQDLPVIlpsIASLTGRGGSPLATALEWVNCScPRCKGSAKRETDTMDTFVDSA-W 527
Cdd:pfam00133 423 SRQRWWGHPIPAWYSEDTEEV-VCRGELVEL---VAGRFEEEGSIKWLHREAKDKS-GSGKGTLEQDEDVLDTWFSSGsW 497
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   528 YYFRYTDPHNTQSPFgsalaDFWMPVDLYIGGKEhavMHLFYarFLSHFCHDQKMVKhREPFHKLLAQGLIkgqtfRLPS 607
Cdd:pfam00133 498 PFSVLGWPFENTEEF-----KKFFPADMLLEGSD---QTRGW--FYRMIMLSTALTG-SVPYKNVLVHGLV-----RDEQ 561
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 23346617   608 GQclkkedidftgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFaAPPEKDILWD 678
Cdd:pfam00133 562 GR----------------------------KMSKSLGNVIDPLDVIDKYGADALRLWLAN-SDYGRDINLS 603
IleS COG0060
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
58-831 3.61e-33

Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 223138 [Multi-domain]  Cd Length: 933  Bit Score: 138.11  E-value: 3.61e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  58 VEKWWHQQIKEQasRVSEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENA 137
Cdd:COG0060  28 LKFWEENDIYEK--IREERNKGKPKFVLHDGPPYANGNIHIGHALNKILKDIIVRYKTMQGYDVPYVPGWDCHGLPIELK 105
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 138 AI----------------ERNLHPESWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDY--YKWtqYLFIKLYEAGLAYQ 199
Cdd:COG0060 106 VEkklgigkkdiesfgveEFREKCREFALEQVDEQKEQFKRLGVWGDWENPYKTMDPSYeeSVW--WAFKELYEKGLLYR 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 200 KEALVNWDPVDQTVLANEQVnEYGcswrsgakvEKKylrqwfiKTTAYAKamqdaladlpewygikgmqahwigdcvgch 279
Cdd:COG0060 184 GYKPVPWSPRCETALAEAEV-EYG---------DVK-------DPSIYVK------------------------------ 216
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 280 ldFTLKVDGEDTGEKLTAYTATPEAIYgiSHVAIspshgllhgcsSVKKALQKALVP--------GRDCLTPVMAVSMLT 351
Cdd:COG0060 217 --FPVKDEGLDENAYLVIWTTTPWTLP--ANLAI-----------AVHPDLDYVLVEvngeklilAKALVESVAKKAGVE 281
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 352 LQEVpIVIMANPDLEG------------------------SLDSKIGI----PSTSSEDTRLAQALGLP----------- 392
Cdd:COG0060 282 DYEV-LETFKGSELEGlryehpfydfvydrafpvilgdhvTLDDGTGLvhtaPGHGEEDYEVGKKYGLLevlnpvddngr 360
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 393 YSE---------VIEASPDGTERL--------SGSAE---------------------FTGMT--RQDAFVALTR----- 427
Cdd:COG0060 361 YTEeapkyeglfVKDANKKIIEDLkekgnllkSEKIEhsyphcwrtktpliyratpqwFVSVDklRDKMLKEINKvnwvp 440
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 428 -KARGmRVGGHVtsNKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQDLpviLPSIASLTGRGGSplaTAL--EWVNC- 503
Cdd:COG0060 441 dWGKN-RFGNMV--ENRPDWCISRQRYWGVPIPVWYCKETGEILVITEEL---EELVGQLVEEKGI---DDWhrPDIDEl 511
                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 504 --SCPRCKGSAKRETDTMDTFVDSawyyfrytdphntqspfGSAladFWmpvdlyiggkehAVMHLF----YARFLSHFC 577
Cdd:COG0060 512 lpPCPEDGKEYRRVPDVLDVWFDS-----------------GST---PY------------AVLHPRenlkFPALFADFY 559
                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 578 ---HDQkmvkHREPFHKLLAQGLIkgqTF-RLPSGQCLKkedIDFTgpapvcaktkekLEVTWEKMSKSKHNGVDPEEIV 653
Cdd:COG0060 560 legSDQ----TRGWFYSSLLTSTA---LFgRAPYKNVLT---HGFV------------LDEKGRKMSKSLGNVVDPQDVI 617
                       730       740       750       760       770       780       790       800
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 654 AQYGIDTIRLYILFAAPPE-----KDILWDVKTdalpgVLRwqqRLWsLTTRFIEARTSGTVPQPQLLnSKEKTKAQNLW 728
Cdd:COG0060 618 DKYGADILRLWVASSDYWEdlrfsDEILKQVRE-----VYR---KIR-NTYRFLLGNLDDFDPKKDAV-LPEELRELDRW 687
                       810       820       830       840       850       860       870       880
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 729 --EYKNAVIAQVTTHFtEDFALNSVVSQLMG-----LSS----------------ALSQASQRVVLHspefeDALCALLV 785
Cdd:COG0060 688 ilSRLNSLVKEVREAY-ENYDFHKVVRALMNfvsedLSNwyldiikdrlyteaadSPDRRAAQTTLY-----HILKALVR 761
                       890       900       910       920
                ....*....|....*....|....*....|....*....|....*.
gi 23346617 786 MAAPLAPHVTSELWAGLTlvpsklcdHYAWDSGVMLQAWPTVDSQF 831
Cdd:COG0060 762 LLAPILPFTAEEIWQNLP--------GERKEESVHLEDWPEVDEEL 799
ileS TIGR00392
isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ...
60-839 7.55e-33

isoleucyl-tRNA synthetase; The isoleucyl tRNA synthetase (IleS) is a class I amino acyl-tRNA ligase and is particularly closely related to the valyl tRNA synthetase. This model may recognize IleS from every species, including eukaryotic cytosolic and mitochondrial forms. [Protein synthesis, tRNA aminoacylation]


Pssm-ID: 273054 [Multi-domain]  Cd Length: 861  Bit Score: 136.74  E-value: 7.55e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    60 KWWHQQIKEqasRVSEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAaI 139
Cdd:TIGR00392  18 FWQENDIFE---KVKKLNKGKPEFIFHDGPPYANGSIHLGHALNKILKDIILRYKTMQGFNVTRKPGWDTHGLPIEHK-V 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   140 ERNLhpeSWTQ---------------------SNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAY 198
Cdd:TIGR00392  94 EKKL---GISGkkeissleieefrekcrefalKQIEEQREQFQRLGVWGDWENPYKTMDPSYEESQWWLFKEAHEKGLLY 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   199 QKEALVNWDPVDQTVLANEQVNEYGCSWR-----------------SGAKVEKKYLRQWfikTTA--------------- 246
Cdd:TIGR00392 171 RGLKPVYWSPRCRTALAEAEVEYKENYKDvkdpsiyvkfpvkkdkkTYLKVKLSSLLIW---TTTpwtlpsnlaiavhpd 247
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   247 --YAKAMQD--------ALADLPEWYGIKGMQAHWIGDCVGCHLD---FTLKVDGEDTGEKLTAYTA------TPEAIYG 307
Cdd:TIGR00392 248 feYALVQDNtkveyfilAKKLVEKLYNKAGSDYEIIKTFKGSDLEgleYEHPLYDFVSQLKEGAPVViggdhvTTEDGTG 327
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   308 ISHvaISPSHGLLHGCSSVKKALqkalvpgrDCLTPVMAVSMLTLQEVPIVIMANPDLEGSLDSKIGIPSTSSEDTRLaq 387
Cdd:TIGR00392 328 IVH--TAPGHGEEDYEIGKKYGL--------EVLSPVDEKGVYTEGVNDFQGRFVKDADKDIIKANKIIIEQLKDKGL-- 395
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   388 algLPYSEVIE----------------ASPDGTERLSGSAEftGMTRQDAFVALTRKARGMRVGGHVTSNKlkDWLISRQ 451
Cdd:TIGR00392 396 ---LLKAEKIThsyphcwrtktpviyrATEQWFIKTKDIKD--QMLEQIKKVNWVPEWGEGRFGNWLENRP--DWCISRQ 468
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   452 RYWGTPIPIVHCPACGPvpvplqdlPVILPSIASL------TGRGGSPLATA---LEWVNCSCPRCkGSAKRETDTMDTF 522
Cdd:TIGR00392 469 RYWGIPIPIWYCEDTGE--------PIVVGSIEELielielKGIDAWFEDLHrdfLDKITLKSGDG-GEYRRVPDVLDVW 539
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   523 VDS--AWyyfrYTDPHNtqsPFGSALADFWMPVDLYIGGkehavmhlfyarflshfcHDQkmvkHREPFHKLLAQGLIkg 600
Cdd:TIGR00392 540 FDSgsMP----YASIHY---PFENEKFKEVFPADFILEG------------------SDQ----TRGWFYSSLAIGTA-- 588
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   601 QTFRLPSGQCLKKediDFTgpapvcaktkekLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPpekdilWD-- 678
Cdd:TIGR00392 589 LFGQAPYKNVITH---GFT------------LDEKGRKMSKSLGNVVDPLKVINKYGADILRLYVASSDP------WEdl 647
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   679 -VKTDALPGVLRWQQRLWSLTTRFI--EARTSGTVPQPQLLnSKEKTKAQNLW--EYKNAVIAQVTTHFtEDFALNSVVS 753
Cdd:TIGR00392 648 rFSDEILKQVVEKYRKIRWNTYRFLltYANLDKFDPLFNSV-AVEKFPEEDRWilSRLNSLVEEVNEAL-EKYNFHKVLR 725
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   754 QLMG-----LSS----------------ALSQASQRVVLHspefedALCALLVMAAPLAPHVTSELWAGLTLVPSKlcdh 812
Cdd:TIGR00392 726 ALQDfiveeLSNwyiriirdrlyceakdNDKRAAQTTLYY------ALLTLVRLLAPFLPHTAEEIYQNLPGGEEE---- 795
                         890       900       910
                  ....*....|....*....|....*....|..
gi 23346617   813 yawdSGVMLQAWPTVDSQFL-----QKPDMVQ 839
Cdd:TIGR00392 796 ----ESVHLNLWPEVDEEFIdealeANMAIVR 823
Ile_Leu_Val_MetRS_core cd00668
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ...
82-677 5.11e-30

catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.


Pssm-ID: 185674 [Multi-domain]  Cd Length: 312  Bit Score: 121.37  E-value: 5.11e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  82 KFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAA-------------IERNLHPESW 148
Cdd:cd00668   1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAerkggrkkktiwiEEFREDPKEF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 149 TQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEalvnwdpvdqtvlaneqvneygcswRS 228
Cdd:cd00668  81 VEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGT-------------------------HP 135
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 229 GAKVEkkylrQWFIKTTAYAKAMQDAL---ADLPEWYGIKgMQAhWIGDcvgchldftlkvdgedtgekltaytatpeai 305
Cdd:cd00668 136 VRITE-----QWFFDMPKFKEKLLKALrrgKIVPEHVKNR-MEA-WLES------------------------------- 177
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 306 ygishvaispshgllhgcssvkkalqkalvpgrdcltpvmavsmltlqevpivimanpdlegsldskigipstssedtrl 385
Cdd:cd00668     --------------------------------------------------------------------------------
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 386 aqalglpysevieaspdgterlsgsaeftgmtrqdafvaltrkargmrvgghvtsnkLKDWLISRQRYWGTPIPivhcpa 465
Cdd:cd00668 178 ---------------------------------------------------------LLDWAISRQRYWGTPLP------ 194
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 466 cgpvpvplqdlpvilpsiasltgrggsplatalewvncscprckgsakreTDTMDTFVDSAWYYFRYTDphntqSPFGSA 545
Cdd:cd00668 195 --------------------------------------------------EDVFDVWFDSGIGPLGSLG-----YPEEKE 219
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 546 LADFWMPVDLYIGGKEHAVMHLFYARFLShfchdqKMVKHREPFHKLLAQGLIKGqtfrlPSGQclkkedidftgpapvc 625
Cdd:cd00668 220 WFKDSYPADWHLIGKDILRGWANFWITML------VALFGEIPPKNLLVHGFVLD-----EGGQ---------------- 272
                       570       580       590       600       610
                ....*....|....*....|....*....|....*....|....*....|..
gi 23346617 626 aktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILW 677
Cdd:cd00668 273 ------------KMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIRL 312
valS PRK05729
valyl-tRNA synthetase; Reviewed
94-831 1.37e-27

valyl-tRNA synthetase; Reviewed


Pssm-ID: 235582 [Multi-domain]  Cd Length: 874  Bit Score: 120.21  E-value: 1.37e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   94 GKLHMGHVRVYTLSDTIARFQKMRGMQVInpmgWdafgLP-------AENAAIERNLHPES-----------------WT 149
Cdd:PRK05729  49 GSLHMGHALNNTLQDILIRYKRMQGYNTL----W----LPgtdhagiATQMVVERQLAAEGksrhdlgrekflekvweWK 120
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  150 QSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVnEYgcswrsg 229
Cdd:PRK05729 121 EESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRLYEKGLIYRGKRLVNWDPKLQTALSDLEV-EY------- 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  230 aKVEKKYLrqWFIKttayakamqdaladlpewYGIkgmqahwigdcvgchldftlkvdgEDTGEKLTAYTATPEAIYGIS 309
Cdd:PRK05729 193 -KEVKGKL--WHIR------------------YPL------------------------ADGSDYLVVATTRPETMLGDT 227
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  310 HVAISPS-----HglLHGcssvkkalQKALVPgrdcltpvmavsmLTLQEVPIVIMANPDLE---GSLdsKIgipsTSSE 381
Cdd:PRK05729 228 AVAVNPEderykH--LIG--------KTVILP-------------LVGREIPIIADEYVDPEfgtGAV--KI----TPAH 278
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  382 DT---RLAQALGLPYSEVIeaSPDGTERLSGsAEFTGMTRqdaFVAltRKA-------------------------RG-- 431
Cdd:PRK05729 279 DPndfEVGKRHNLPMINIM--DEDGTINENP-GEYQGLDR---FEA--RKAivadleelgllvkiephthsvghsdRSgv 350
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  432 -------------M-----RVGGHVTS------------------NKLKDWLISRQRYWGTPIPIVHCPAcGPVPVPLQD 475
Cdd:PRK05729 351 viepylsdqwfvkMkplakPALEAVENgeikfvperwektyfhwmENIQDWCISRQLWWGHRIPAWYDED-GEVYVGREE 429
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  476 LpvilpsiasltgrggsplatalewvncsCPRCKGSAKRETDTMDTFVDSA--------WyyfrytdPHNTQspfgsALA 547
Cdd:PRK05729 430 P----------------------------EAREKALLTQDEDVLDTWFSSAlwpfstlgW-------PEKTE-----DLK 469
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  548 DFWmPVDLYIGGkehavmH--LFY--AR--FLSHFCHDQKmvkhrePFHKLLAQGLI---KGQtfrlpsgqclkkedidf 618
Cdd:PRK05729 470 RFY-PTSVLVTG------FdiIFFwvARmiMMGLHFTGQV------PFKDVYIHGLVrdeQGR----------------- 519
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  619 tgpapvcaktkeklevtweKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDILWDVKtdalpgvlRWQQ------ 692
Cdd:PRK05729 520 -------------------KMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIRFDEE--------RVEGyrnfan 572
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  693 RLWSlTTRFIEARTSGTVPqPQLLNSKEKTKAqNLW---EYkNAVIAQVTTHFtEDFALNSVVSQLMG------------ 757
Cdd:PRK05729 573 KLWN-ASRFVLMNLEGADV-GELPDPEELSLA-DRWilsRL-NRTVAEVTEAL-DKYRFDEAARALYEfiwnefcdwyle 647
                        810       820       830       840       850       860       870
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 23346617  758 -----LSSALSQASQRVVLHspefedALCALLVMAAPLAPHVTSELWAGLTlvpsklcdHYAWDSGVMLQAWPTVDSQF 831
Cdd:PRK05729 648 lakpvLQEAAKRATRATLAY------VLEQILRLLHPFMPFITEELWQKLA--------PLGIEESIMLAPWPEADEAI 712
MetG COG0143
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];
77-272 2.39e-24

Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis];


Pssm-ID: 223221 [Multi-domain]  Cd Length: 558  Bit Score: 108.52  E-value: 2.39e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  77 DKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKHM 156
Cdd:COG0143   1 MKMMKKILVTTALPYPNGPPHLGHLYTYLAADVYARYLRLRGYEVFFLTGTDEHGTKIELKAEKEGITPQELVDKNHEEF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 157 RKQLDRLGLcfSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQV---------------NE 221
Cdd:COG0143  81 KELFKALNI--SFDNFIRTTSPEHKELVQEFFLKLYENGDIYLREYEGLYCVSCERFLPDRYVegtcpkcggedargdQC 158
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 23346617 222 YGC-------------SWRSGAKVEKKYLRQWFIKTTAYAKAMQDALADLPEWYGIKGMQAHWI 272
Cdd:COG0143 159 ENCgrtldptelinpvCVISGATPEVREEEHYFFRLSKFQDKLLEWYESNPDFIWPANRRNEVL 222
Anticodon_Ia_Leu_BEm cd07958
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ...
677-802 3.64e-24

Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.


Pssm-ID: 153412 [Multi-domain]  Cd Length: 117  Bit Score: 98.06  E-value: 3.64e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 677 WDvkTDALPGVLRWQQRLWSLTTRFIEARTSGTVPQpqllnsKEKTKAQNLWEYKNAVIAQVTTHFtEDFALNSVVSQLM 756
Cdd:cd07958   1 WS--DSGVEGAYRFLNRVWRLVTELAEALAAPAAAA------ELSEEDKELRRKLHKTIKKVTEDI-ERLRFNTAIAALM 71
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 23346617 757 GLSSALSQASQRVVLHSPEFEDALCALLVMAAPLAPHVTSELWAGL 802
Cdd:cd07958  72 ELVNALYKYKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEEL 117
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
82-261 8.90e-23

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 100.30  E-value: 8.90e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  82 KFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKHMRKQLD 161
Cdd:cd00814   1 KVLITTALPYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQKAEEEGVTPQELCDKYHEIFKDLFK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 162 RLGlcFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLAneqvneygcswrsgakvEKKYLRQWF 241
Cdd:cd00814  81 WLN--ISFDYFIRTTSPRHKEIVQEFFKKLYENGYIYEGEYEGLYCVSCERFLP-----------------EWREEEHYF 141
                       170       180
                ....*....|....*....|
gi 23346617 242 IKTTAYAKAMQDALADLPEW 261
Cdd:cd00814 142 FRLSKFQDRLLEWLEKNPDF 161
valS PRK14900
valyl-tRNA synthetase; Provisional
56-829 1.34e-20

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 97.76  E-value: 1.34e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    56 KDVEKWWHQQIKEQAS-RVSEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLpA 134
Cdd:PRK14900   22 REVEARWYPFWQERGYfHGDEHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGTDHAGI-A 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   135 ENAAIERNLHPE------------------SWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGL 196
Cdd:PRK14900  101 TQMIVEKELKKTekksrhdlgreaflervwAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVRLHEEGL 180
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   197 AYQKEALVNWDPVDQTVLANEQVN----EYGCSWrSGAKVEKKYLRQWFIKTTAYAKAMQD-ALADLPEwygikgmqAHW 271
Cdd:PRK14900  181 IYREKKLINWCPDCRTALSDLEVEheeaHQGELW-SFAYPLADGSGEIVVATTRPETMLGDtAVAVHPL--------DPR 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   272 IGDCVGCHLdfTLKVDGEDTGEKLTAYTATPEaiYGISHVAISPSH-------GLLHGcssvkkaLQKALVPGRDCLTPV 344
Cdd:PRK14900  252 YMALHGKKV--RHPITGRTFPIVADAILVDPK--FGTGAVKVTPAHdfndfevGKRHG-------LEMITVIGPDGRMTA 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   345 MAVSMLTL------QEVPIVIMANPDLEGSLDSKIGIPSTSSEDTRLAQALGLPYSEVIE--ASPDGTERLSGSAEFTGM 416
Cdd:PRK14900  321 EAGPLAGLdrfearKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEplARPAIEAVEQGRTRFIPE 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   417 TRQDAFVALTRkargmrvgghvtsnKLKDWLISRQRYWGTPIPIVHCPACGPVPVPLQdlpvilPSiasltgrggsplat 496
Cdd:PRK14900  401 QWTNTYMAWMR--------------NIHDWCISRQLWWGHQIPAWYCPDGHVTVARET------PE-------------- 446
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   497 alewvncSCPRCKGSAKRE-TDTMDTFVDSA-WYYFRYTDPHNTQSpfgsaLADFWmPVDLYIGGkeHAVMHLFYARFLS 574
Cdd:PRK14900  447 -------ACSTCGKAELRQdEDVLDTWFSSGlWPFSTMGWPEQTDT-----LRTFY-PTSVMETG--HDIIFFWVARMMM 511
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   575 ---HFCHDQkmvkhrePFHKLLAQGLIKgqtfrlpsgqclkkediDFTGpapvcaktkeklevtwEKMSKSKHNGVDPEE 651
Cdd:PRK14900  512 mglHFMGEV-------PFRTVYLHPMVR-----------------DEKG----------------QKMSKTKGNVIDPLV 551
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   652 IVAQYGIDTIRLYILFAAPPEKDIlwDVKTDALPGVLRWQQRLW-------------------------SLTTRFIEART 706
Cdd:PRK14900  552 ITEQYGADALRFTLAALTAQGRDI--KLAKERIEGYRAFANKLWnasrfalmnlsgyqergedparlarTPADRWILARL 629
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   707 SGTVPQpqllnSKEKTKAQNLWEYKNAVIAQVTTHFTeDFALNSVVSQLMGLSSALSQASQRVVLHSpefedaLCALLVM 786
Cdd:PRK14900  630 QRAVNE-----TVEALEAFRFNDAANAVYAFVWHELC-DWYIELAKEALASEDPEARRSVQAVLVHC------LQTSYRL 697
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|...
gi 23346617   787 AAPLAPHVTSELWAGLTLVPSKlcdhYAWDSGVMLQAWPTVDS 829
Cdd:PRK14900  698 LHPFMPFITEELWHVLRAQVGA----SAWADSVLAAEYPRKGE 736
IleRS_core cd00818
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ...
81-675 9.64e-19

catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.


Pssm-ID: 173909 [Multi-domain]  Cd Length: 338  Bit Score: 88.44  E-value: 9.64e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  81 PKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAA----------IERNLHPE---- 146
Cdd:cd00818   1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVekelgisgkkDIEKMGIAefna 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 147 ---SWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWdPVDQtvlaneqvneyg 223
Cdd:cd00818  81 kcrEFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW-PLIY------------ 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 224 cswrsgakvekKYLRQWFIKTTAYAKAMQDALadlpewygikgMQAHWIgdcvgchldftlkvdgedtgekltaytatpe 303
Cdd:cd00818 148 -----------RATPQWFIRVTKIKDRLLEAN-----------DKVNWI------------------------------- 174
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 304 aiygishvaisPSHGllhgcssvkkalqkalvpgrdcltpvmavsmltlqevpivimanpdlegsldskigipstssedt 383
Cdd:cd00818 175 -----------PEWV----------------------------------------------------------------- 178
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 384 rlaqalglpysevieaspdgterlsgsaeftgmtrQDAFVALTRKARgmrvgghvtsnklkDWLISRQRYWGTPIPIVHC 463
Cdd:cd00818 179 -----------------------------------KNRFGNWLENRR--------------DWCISRQRYWGTPIPVWYC 209
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 464 PACGPVPVplqdlpvilpsiasltgrggsplatalewvncscprckgsaKRETDTMDTFVDS--AWYYFRytdpHNtqsP 541
Cdd:cd00818 210 EDCGEVLV-----------------------------------------RRVPDVLDVWFDSgsMPYAQL----HY---P 241
                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617 542 FGSALADFWMPVDLYIGGkehavmhlfyarflshfcHDQkmvkHREPFHKLLAQGLIkgqTF-RLPSGQCLKKEDI-DFT 619
Cdd:cd00818 242 FENEDFEELFPADFILEG------------------SDQ----TRGWFYSLLLLSTA---LFgKAPYKNVIVHGFVlDED 296
                       570       580       590       600       610
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 23346617 620 GpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKDI 675
Cdd:cd00818 297 G----------------RKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDL 336
tRNA-synt_1g pfam09334
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
83-219 1.77e-18

tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.


Pssm-ID: 401322 [Multi-domain]  Cd Length: 387  Bit Score: 88.50  E-value: 1.77e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    83 FYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKHMRKQLDR 162
Cdd:pfam09334   1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAEKEGITPEELVDRYHEIHREDFKK 80
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 23346617   163 LGLcfSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLANEQV 219
Cdd:pfam09334  81 FNI--SFDDYGRTTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYV 135
leuS PRK12300
leucyl-tRNA synthetase; Reviewed
96-213 2.66e-17

leucyl-tRNA synthetase; Reviewed


Pssm-ID: 237049 [Multi-domain]  Cd Length: 897  Bit Score: 86.85  E-value: 2.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   96 LHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLP----AENAA------IE--RNLH------------PESWTQS 151
Cdd:PRK12300   1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGTPilgiAERIArgdpetIElyKSLYgipeeelekfkdPEYIVEY 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23346617  152 NIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTV 213
Cdd:PRK12300  81 FSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNP 142
PRK11893 PRK11893
methionyl-tRNA synthetase; Reviewed
82-261 4.67e-17

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237012 [Multi-domain]  Cd Length: 511  Bit Score: 85.32  E-value: 4.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   82 KFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKHMRKQLD 161
Cdd:PRK11893   2 KFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDEHGQKIQRKAEEAGISPQELADRNSAAFKRLWE 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  162 RLGlcFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQKEAL--------VNWDPvdqtvlaNEQVNEYGCSWRSGAKVE 233
Cdd:PRK11893  82 ALN--ISYDDFIRTTDPRHKEAVQEIFQRLLANGDIYLGKYEgwycvrceEFYTE-------SELIEDGYRCPPTGAPVE 152
                        170       180
                 ....*....|....*....|....*...
gi 23346617  234 KKYLRQWFIKTTAYAKAMQDALADLPEW 261
Cdd:PRK11893 153 WVEEESYFFRLSKYQDKLLELYEANPDF 180
PTZ00419 PTZ00419
valyl-tRNA synthetase-like protein; Provisional
56-831 7.79e-17

valyl-tRNA synthetase-like protein; Provisional


Pssm-ID: 240411 [Multi-domain]  Cd Length: 995  Bit Score: 85.44  E-value: 7.79e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   56 KDVE----KWWHQ----QIKEQASRVSEEDKlkpkFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGW 127
Cdd:PTZ00419  31 KEVEsgwyEWWEKsgffKPAEDAKSLNSGKK----FVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWVPGT 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  128 DAFGLpAENAAIERNLHPES------------------WTQ---SNIKhmrKQLDRLGLCFSWDREITTCLPDYYKWTQY 186
Cdd:PTZ00419 107 DHAGI-ATQVVVEKKLMKEEnktrhdlgreeflkkvweWKDkhgNNIC---NQLRRLGSSLDWSREVFTMDEQRSKAVKE 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  187 LFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVNEygcswrsgAKVEKKYlrqwFIKTTAYAKAMQdaladlpewygikg 266
Cdd:PTZ00419 183 AFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEF--------EEIEKPT----KITIPGYDKKVE-------------- 236
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  267 MQAHWigdcvgcHLDFTLKVDGEdtgEKLTAYTATPEAIYGISHVAISP-----SHglLHGCSsvkkaLQKALVPGRDcl 341
Cdd:PTZ00419 237 VGVLW-------HFAYPLEDSGQ---EEIVVATTRIETMLGDVAVAVHPkderyKK--LHGKE-----LIHPFIPDRK-- 297
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  342 tpvmavsmltlqevpIVIMANPDLegsLDSKIG------IPSTSSEDTRLAQALGLPYSEVIEAspDGTERLSGsAEFTG 415
Cdd:PTZ00419 298 ---------------IPIIADDEL---VDMEFGtgavkiTPAHDPNDYEIAKRHNLPFINIFTL--DGKINENG-GEFAG 356
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  416 MTRQDAFVALTRK-----------ARGMRVG-----------------------------GHVTSNKLK----------- 444
Cdd:PTZ00419 357 MHRFDCRRKIEEElkemgllrdkvPNPMRLPrcsrsgdivepmlipqwyvnckdmakravEAVRNGELKiipsshenvwy 436
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  445 -------DWLISRQRYWGTPIPIVHCPACGPVPVPL-QDLPVILPSIAsltgrggSPLATALEWVNCSCPRCkgSAKRET 516
Cdd:PTZ00419 437 hwleniqDWCISRQLWWGHRIPAYRVISKGPETDPSdEEPWVVARSEE-------EALEKAKKKFGLSEEDF--ELEQDE 507
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  517 DTMDTFVDSAWYYFrytdphntqSPFG--SALADF--WMPVDLYIGGkeHAVMHLFYARFLSHFCHDQKMVkhrePFHKL 592
Cdd:PTZ00419 508 DVLDTWFSSGLFPF---------STLGwpDQTDDLqrFFPTSLLETG--SDILFFWVARMVMMSLHLTDKL----PFKTV 572
                        650       660       670       680       690       700       710       720
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  593 LAQGLIKgqtfrlpsgqclkkediDFTGpapvcaktkeklevtwEKMSKSKHNGVDPEEIVAqyGI------DTIRLYIL 666
Cdd:PTZ00419 573 FLHAMVR-----------------DSQG----------------EKMSKSKGNVIDPLEVIE--GIslqdlnQKLYEGNL 617
                        730       740       750       760       770       780       790       800
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  667 faapPEKDILWDVK--------------TDALP-GVLRWQQ--------------------RLWSlTTRFIEARTSGTVP 711
Cdd:PTZ00419 618 ----PEKEIKRAIElqkkefpngipecgTDALRfGLLAYTQqgrninldinrvvgyrhfcnKLWN-AVKFALMKLLKDFN 692
                        810       820       830       840       850       860       870       880
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  712 QPQLLNSKEKTKAQNLWEYK------NAVIAQVTTHFTE-DFAL--NSVVS----QL-------------MGLSSALSQA 765
Cdd:PTZ00419 693 LPNSTLFKPNNVESLPWEDKwilhrlNVAIKEVTEGFKEyDFSEatQATYNfwlyELcdvylelikprlsKQSDGERKQH 772
                        890       900       910       920       930       940
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 23346617  766 SQRVVLHSPEFEdalcalLVMAAPLAPHVTSELWAGLTLVPSKLcdhyawdSGVMLQAWPTVDSQF 831
Cdd:PTZ00419 773 AQDVLHTVLDIG------LRLLHPMMPFITEELYQRLPNYLRKS-------ESISIAKYPQPNPGW 825
PLN02943 PLN02943
aminoacyl-tRNA ligase
48-460 6.66e-14

aminoacyl-tRNA ligase


Pssm-ID: 215509 [Multi-domain]  Cd Length: 958  Bit Score: 76.13  E-value: 6.66e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   48 KEYTLQTRKDVEKWWHQQ--IKEQASRVSEEdklkpkfYLLSMfPYP--SGKLHMGHVRVYTLSDTIARFQKMRGMQVIN 123
Cdd:PLN02943  59 KSFDFTSEERIYNWWESQgyFKPNFDRGGDP-------FVIPM-PPPnvTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLW 130
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  124 PMGWDAFGLpAENAAIERNLHPE-----------------SWTQSNIKHMRKQLDRLGLCFSWDREITTcLPDYYKWTQY 186
Cdd:PLN02943 131 IPGTDHAGI-ATQLVVEKMLASEgikrtdlgrdeftkrvwEWKEKYGGTITNQIKRLGASCDWSRERFT-LDEQLSRAVV 208
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  187 -LFIKLYEAGLAYQKEALVNWDPVDQTVLANEQVnEYgcSWRSGakvekkylRQWFIKttayakamqdaladlpewYGIK 265
Cdd:PLN02943 209 eAFVRLHEKGLIYQGSYMVNWSPNLQTAVSDLEV-EY--SEEPG--------TLYYIK------------------YRVA 259
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  266 GmqahwigdcvgchldftlkvdgeDTGEKLTAYTATPEAIYGISHVAISPSHGLLHgcssvKKALQKALVPgrdcltpvm 345
Cdd:PLN02943 260 G-----------------------GSEDFLTIATTRPETLFGDVAIAVNPEDDRYS-----KYIGKMAIVP--------- 302
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  346 avsMLTLQEVPIVIMANPDLE-GSLDSKIgIPSTSSEDTRLAQALGLPYSEVIeaSPDGT-------------ERLSGSA 411
Cdd:PLN02943 303 ---MTYGRHVPIIADRYVDKDfGTGVLKI-SPGHDHNDYLLARKLGLPILNVM--NKDGTlnevaglywfearEKLWSDL 376
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  412 EFTGMT------------------------RQDAFVA---LTRKA--------------RGMRVGGHVTSNkLKDWLISR 450
Cdd:PLN02943 377 EETGLAvkkephtlrvprsqrggevieplvSKQWFVTmepLAEKAlkavengeltiipeRFEKIYNHWLSN-IKDWCISR 455
                        490
                 ....*....|
gi 23346617  451 QRYWGTPIPI 460
Cdd:PLN02943 456 QLWWGHRIPV 465
PLN02843 PLN02843
isoleucyl-tRNA synthetase
47-222 1.22e-12

isoleucyl-tRNA synthetase


Pssm-ID: 215452 [Multi-domain]  Cd Length: 974  Bit Score: 72.11  E-value: 1.22e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   47 TKEYTLQtrkdveKWWHQ-QIKEqasRVSEEDKLKPkFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPM 125
Cdd:PLN02843   7 TREPEIQ------KLWEEnQVYK---RVSDRNNGES-FTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVP 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  126 GWDAFGLPAE-------NAAIERNLHP-------ESWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKL 191
Cdd:PLN02843  77 GWDCHGLPIElkvlqslDQEARKELTPiklrakaAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQM 156
                        170       180       190
                 ....*....|....*....|....*....|.
gi 23346617  192 YEAGLAYQKEALVNWDPVDQTVLANEQVnEY 222
Cdd:PLN02843 157 FLNGYIYRGRKPVHWSPSSRTALAEAEL-EY 186
PLN02381 PLN02381
valyl-tRNA synthetase
58-459 3.08e-12

valyl-tRNA synthetase


Pssm-ID: 215214 [Multi-domain]  Cd Length: 1066  Bit Score: 70.70  E-value: 3.08e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    58 VEKWWHQQIKEQASRVSEEDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLpAENA 137
Cdd:PLN02381  105 VEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVDHAGI-ATQV 183
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   138 AIERNLHPE------------------SWTQSNIKHMRKQLDRLGLCFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQ 199
Cdd:PLN02381  184 VVEKKLMRErhltrhdigreefvsevwKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRLYKEGLIYR 263
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   200 KEALVNWDPVDQTVLANEQVNeygcswrsgaKVEKKylRQWFIKTTAYAKAMQdaladlpewygikgmqahwigdcVGCH 279
Cdd:PLN02381  264 DIRLVNWDCTLRTAISDVEVD----------YIDIK--ERTLLKVPGYDKPVE-----------------------FGVL 308
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   280 LDFTLKVDGeDTGEKLTAYTATpEAIYGISHVAISP-----SHglLHGcssvkkalqkalvpgrdcltpVMAVSMLTLQE 354
Cdd:PLN02381  309 TSFAYPLEG-GLGEIVVATTRI-ETMLGDTAIAIHPdderyKH--LHG---------------------KFAVHPFNGRK 363
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   355 VPIV---IMANPDLeGSLDSKIgIPSTSSEDTRLAQALGLPYSEVIeaSPDGTERLSGSAEFTGMTRQDAFVALTR--KA 429
Cdd:PLN02381  364 LPIIcdaILVDPNF-GTGAVKI-TPAHDPNDFEVGKRHNLEFINIF--TDDGKINSNGGSEFAGMPRFAAREAVIEalQK 439
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   430 RG---------MRVGGHVTSN--------------------------------------------------KLKDWLISR 450
Cdd:PLN02381  440 KGlyrgaknneMRLGLCSRTNdvvepmikpqwfvncssmakqaldaaidgenkklefipkqylaewkrwleNIRDWCISR 519

                  ....*....
gi 23346617   451 QRYWGTPIP 459
Cdd:PLN02381  520 QLWWGHRIP 528
metG PRK00133
methionyl-tRNA synthetase; Reviewed
90-215 1.30e-10

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 234655 [Multi-domain]  Cd Length: 673  Bit Score: 65.17  E-value: 1.30e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   90 PYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTqSNIKHMRKQ-LDRLGLCF- 167
Cdd:PRK00133  11 PYANGPIHLGHLVEYIQADIWVRYQRMRGHEVLFVCADDAHGTPIMLKAEKEGITPEELI-ARYHAEHKRdFAGFGISFd 89
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 23346617  168 SWDReitTCLPDYYKWTQYLFIKLYEAGLAYQKEALVNWDPVDQTVLA 215
Cdd:PRK00133  90 NYGS---THSEENRELAQEIYLKLKENGYIYEKTIEQLYDPEKGMFLP 134
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
80-195 4.97e-10

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 63.28  E-value: 4.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   80 KPKFYLLSMFPYPSGKLHMGHVrvYT--LSDTIARFQKMRGMQVINPMGWDAFGLPAENAAIERNLHPESWTQSNIKHMR 157
Cdd:PRK12267   3 KKTFYITTPIYYPNGKPHIGHA--YTtiAADALARYKRLQGYDVFFLTGTDEHGQKIQQAAEKAGKTPQEYVDEISAGFK 80
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 23346617  158 KQLDRLGLcfSWDREITTCLPDYYKWTQYLFIKLYEAG 195
Cdd:PRK12267  81 ELWKKLDI--SYDKFIRTTDERHKKVVQKIFEKLYEQG 116
tRNA-synt_1_2 pfam13603
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ...
270-429 7.70e-10

Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.


Pssm-ID: 433342 [Multi-domain]  Cd Length: 185  Bit Score: 59.10  E-value: 7.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   270 HWIGDCVGCHLDFTLkvdgEDTGEKLTAYTATPEAIYGISHVAISPSHGLLHGCSSVKKALQK---------------AL 334
Cdd:pfam13603   2 NWIGRSEGAEITFPV----EGTDEKIEVFTTRPDTLMGVTFVALAPEHPLVEKLAEKNPEVAAfieeckntseiertsET 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   335 VPGRDCLTPVMAVSMLTLQEVPIVImANPDLE--GSlDSKIGIPSTSSEDTRLAQALGLPYSEVIEaSPDGTE------- 405
Cdd:pfam13603  78 KEKEGVFTGLYAIHPITGEKIPIWI-ANFVLMeyGT-GAVMAVPAHDQRDFEFAKKYNLPIKPVIQ-PEDGDLdldimte 154
                         170       180       190
                  ....*....|....*....|....*....|
gi 23346617   406 ------RLSGSAEFTGMTRQDAFVALTRKA 429
Cdd:pfam13603 155 ayteegILVNSGEFDGLDSEEAKEAIIKKL 184
PLN02882 PLN02882
aminoacyl-tRNA ligase
67-199 2.58e-08

aminoacyl-tRNA ligase


Pssm-ID: 215477 [Multi-domain]  Cd Length: 1159  Bit Score: 57.81  E-value: 2.58e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    67 KEQASRvseeDKLKPKFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFGLPAENaAIERNLhpe 146
Cdd:PLN02882   28 KTQLKR----TEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEY-EIDKKL--- 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   147 swtqsNIKHmRKQLDRLGL------CFS--------WDREITTC-----LPDYYK----------WtqYLFIKLYEAGLA 197
Cdd:PLN02882  100 -----GIKR-RDDVLKMGIdkyneeCRSivtryskeWEKTVTRTgrwidFENDYKtmdpkfmesvW--WVFKQLFEKGLV 171

                  ..
gi 23346617   198 YQ 199
Cdd:PLN02882  172 YK 173
MetRS_core cd00814
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ...
637-674 3.91e-08

catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.


Pssm-ID: 173907 [Multi-domain]  Cd Length: 319  Bit Score: 56.00  E-value: 3.91e-08
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 23346617 637 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAPPEKD 674
Cdd:cd00814 279 KKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKD 316
Anticodon_1 pfam08264
Anticodon-binding domain of tRNA; This domain is found mainly hydrophobic tRNA synthetases. ...
732-848 4.92e-08

Anticodon-binding domain of tRNA; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA.


Pssm-ID: 400523 [Multi-domain]  Cd Length: 141  Bit Score: 52.79  E-value: 4.92e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   732 NAVIAQVTTHFtEDFALNSVVSQLM-GLSSALS----QASQRVVLHSPEFEDA-------LCALLVMAAPLAPHVTSELW 799
Cdd:pfam08264   9 NKLIKEVTEAY-ENYRFNTAAQALYeFFWNDLSdwylELIKDRLYGEEPDSRAqttlyevLETLLRLLAPFMPFITEELW 87
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 23346617   800 AGLTlvpsklcdhyawdsgVMLQAWPTV----DSQFLQKPDMVQMAVLINNKA 848
Cdd:pfam08264  88 QKES---------------IHLAPWPEDaeleEAELEEAFELRQEIVQAIRKL 125
PRK12267 PRK12267
methionyl-tRNA synthetase; Reviewed
637-670 1.18e-06

methionyl-tRNA synthetase; Reviewed


Pssm-ID: 237028 [Multi-domain]  Cd Length: 648  Bit Score: 52.11  E-value: 1.18e-06
                         10        20        30
                 ....*....|....*....|....*....|....
gi 23346617  637 EKMSKSKHNGVDPEEIVAQYGIDTIRLYILFAAP 670
Cdd:PRK12267 298 GKMSKSKGNVVDPEELVDRYGLDALRYYLLREVP 331
PLN02959 PLN02959
aminoacyl-tRNA ligase
52-138 2.72e-06

aminoacyl-tRNA ligase


Pssm-ID: 215518 [Multi-domain]  Cd Length: 1084  Bit Score: 51.22  E-value: 2.72e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617    52 LQTRKDVEKWWHQQIKEQASRVSEEDKLKPKFYllSMFPYP--SGKLHMGHvrVYTLSDTI--ARFQKMRGMQVINPMGW 127
Cdd:PLN02959   16 LEIEVAVQKWWEEEKVFEAEAGDEPPKPGEKFF--GNFPYPymNGLLHLGH--AFSLSKLEfaAAYHRLRGANVLLPFAF 91
                          90
                  ....*....|.
gi 23346617   128 DAFGLPAENAA 138
Cdd:PLN02959   92 HCTGMPIKASA 102
PTZ00427 PTZ00427
isoleucine-tRNA ligase, putative; Provisional
444-666 4.36e-06

isoleucine-tRNA ligase, putative; Provisional


Pssm-ID: 173617 [Multi-domain]  Cd Length: 1205  Bit Score: 50.74  E-value: 4.36e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   444 KDWLISRQRYWGTPIPIVHCPACGPVpvplqdlpVILPSIASLTGRGGSPLATAL-----EWVNCSCPRCKG--SAKRET 516
Cdd:PTZ00427  569 KDWCISRNRYWGTPIPIWADEKMETV--------ICVESIKHLEELSGVKNINDLhrhfiDHIEIKNPKGKTypKLKRIP 640
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   517 DTMDTFVDSAwyYFRYTDPHntqSPFGSALADFW--MPVDLYIGGKEHAVMHLFYARFLSHFCHDqkmvkhREPFHKLLA 594
Cdd:PTZ00427  641 EVFDCWFESG--SMPYAKVH---YPFSTEKEDFHkiFPADFIAEGLDQTRGWFYTLLVISTLLFD------KAPFKNLIC 709
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 23346617   595 QGLIkgqtfrlpsgqclkkedidftgpapvcaktkekLEVTWEKMSKSKHNGVDPEEIVAQYGIDTIRLYIL 666
Cdd:PTZ00427  710 NGLV---------------------------------LASDGKKMSKRLKNYPDPLYILDKYGADSLRLYLI 748
PLN02224 PLN02224
methionine-tRNA ligase
69-272 6.19e-04

methionine-tRNA ligase


Pssm-ID: 177869 [Multi-domain]  Cd Length: 616  Bit Score: 43.55  E-value: 6.19e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617   69 QASRVSEEDKlkpkFYLLSMFPYPSGKLHMGHVRVYTLSDTIARFQKMRGMQVINPMGWDAFG--LPAENAAIERN--LH 144
Cdd:PLN02224  61 QESTVDEADT----FVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGekIATSAAANGRNppEH 136
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  145 PESWTQSnIKHMRKQLDrlglcFSWDREITTCLPDYYKWTQYLFIKLYEAGLAYQK--EAL--VNWDPV--DQTVLANE- 217
Cdd:PLN02224 137 CDIISQS-YRTLWKDLD-----IAYDKFIRTTDPKHEAIVKEFYARVFANGDIYRAdyEGLycVNCEEYkdEKELLENNc 210
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 23346617  218 -QVNEYGCSwrsgAKVEKKYlrqwFIKTTAYAKAMQDALADLPEW----YGIKGMQAhWI 272
Cdd:PLN02224 211 cPVHQMPCV----ARKEDNY----FFALSKYQKPLEDILAQNPRFvqpsYRLNEVQS-WI 261
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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