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Conserved domains on  [gi|223633935|ref|NP_694988|]
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proline and serine-rich protein 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SARG super family cl25900
Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, ...
398-433 3.92e-07

Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.


The actual alignment was detected with superfamily member pfam15385:

Pssm-ID: 464692 [Multi-domain]  Cd Length: 568  Bit Score: 52.10  E-value: 3.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 223633935  398 ADSLPRPQGITVQFAGRGSSEEARREALRKLGLLRE 433
Cdd:pfam15385 533 RDKLPRPPCVSVKISPKGVPDEHRREALKKLGLLKE 568
PHA03247 super family cl33720
large tegument protein UL36; Provisional
92-405 6.76e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 6.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935   92 PSLEESTSSPSEPEDVIDLVQPAPGAGEAEGLPEGTQAAGPAPagKEHRKQDAETPPPPDPPAPETLLAPPPLPSTPDPP 171
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPP--ERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR 2684
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935  172 RRELRAPSPPVEH-------PRLLRSVPTPLVMAQKISERMAGNEALSPTSPFREGRPGEWRTPAA-RGPRSGDPGPGPS 243
Cdd:PHA03247 2685 RRAARPTVGSLTSladppppPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATpGGPARPARPPTTA 2764
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935  244 HPAQPKAPRFPsniiVTNGAAREPRRTLSRAAVSVQERRAQVLATIHGHAGAFPAAGDAGEGAPGGGSSPERVARGRGLP 323
Cdd:PHA03247 2765 GPPAPAPPAAP----AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935  324 GPAESLR-----AGGQAPRGPALANGFPSAHEALKSAPSSfaPAGKSLcfrPGPALPstRARQSFPGPrqPNGAQDWRRA 398
Cdd:PHA03247 2841 PPPGPPPpslplGGSVAPGGDVRRRPPSRSPAAKPAAPAR--PPVRRL---ARPAVS--RSTESFALP--PDQPERPPQP 2911

                  ....*..
gi 223633935  399 DSLPRPQ 405
Cdd:PHA03247 2912 QAPPPPQ 2918
 
Name Accession Description Interval E-value
SARG pfam15385
Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, ...
398-433 3.92e-07

Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.


Pssm-ID: 464692 [Multi-domain]  Cd Length: 568  Bit Score: 52.10  E-value: 3.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 223633935  398 ADSLPRPQGITVQFAGRGSSEEARREALRKLGLLRE 433
Cdd:pfam15385 533 RDKLPRPPCVSVKISPKGVPDEHRREALKKLGLLKE 568
PHA03247 PHA03247
large tegument protein UL36; Provisional
92-405 6.76e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 6.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935   92 PSLEESTSSPSEPEDVIDLVQPAPGAGEAEGLPEGTQAAGPAPagKEHRKQDAETPPPPDPPAPETLLAPPPLPSTPDPP 171
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPP--ERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR 2684
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935  172 RRELRAPSPPVEH-------PRLLRSVPTPLVMAQKISERMAGNEALSPTSPFREGRPGEWRTPAA-RGPRSGDPGPGPS 243
Cdd:PHA03247 2685 RRAARPTVGSLTSladppppPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATpGGPARPARPPTTA 2764
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935  244 HPAQPKAPRFPsniiVTNGAAREPRRTLSRAAVSVQERRAQVLATIHGHAGAFPAAGDAGEGAPGGGSSPERVARGRGLP 323
Cdd:PHA03247 2765 GPPAPAPPAAP----AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935  324 GPAESLR-----AGGQAPRGPALANGFPSAHEALKSAPSSfaPAGKSLcfrPGPALPstRARQSFPGPrqPNGAQDWRRA 398
Cdd:PHA03247 2841 PPPGPPPpslplGGSVAPGGDVRRRPPSRSPAAKPAAPAR--PPVRRL---ARPAVS--RSTESFALP--PDQPERPPQP 2911

                  ....*..
gi 223633935  399 DSLPRPQ 405
Cdd:PHA03247 2912 QAPPPPQ 2918
 
Name Accession Description Interval E-value
SARG pfam15385
Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, ...
398-433 3.92e-07

Specifically androgen-regulated gene protein; This family of proteins is found in eukaryotes, the function of this protein is still unknown but it is thought to be an androgen receptor. Protein expression is up-regulated in the presence of androgens, but not in the presence of glucocorticoids. SARG tends to be highly expressed in prostate tissue. Proteins in this family are typically between 340 and 587 amino acids in length. There is a conserved EETI sequence motif.


Pssm-ID: 464692 [Multi-domain]  Cd Length: 568  Bit Score: 52.10  E-value: 3.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 223633935  398 ADSLPRPQGITVQFAGRGSSEEARREALRKLGLLRE 433
Cdd:pfam15385 533 RDKLPRPPCVSVKISPKGVPDEHRREALKKLGLLKE 568
PHA03247 PHA03247
large tegument protein UL36; Provisional
92-405 6.76e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 6.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935   92 PSLEESTSSPSEPEDVIDLVQPAPGAGEAEGLPEGTQAAGPAPagKEHRKQDAETPPPPDPPAPETLLAPPPLPSTPDPP 171
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPP--ERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPR 2684
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935  172 RRELRAPSPPVEH-------PRLLRSVPTPLVMAQKISERMAGNEALSPTSPFREGRPGEWRTPAA-RGPRSGDPGPGPS 243
Cdd:PHA03247 2685 RRAARPTVGSLTSladppppPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATpGGPARPARPPTTA 2764
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935  244 HPAQPKAPRFPsniiVTNGAAREPRRTLSRAAVSVQERRAQVLATIHGHAGAFPAAGDAGEGAPGGGSSPERVARGRGLP 323
Cdd:PHA03247 2765 GPPAPAPPAAP----AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPP 2840
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935  324 GPAESLR-----AGGQAPRGPALANGFPSAHEALKSAPSSfaPAGKSLcfrPGPALPstRARQSFPGPrqPNGAQDWRRA 398
Cdd:PHA03247 2841 PPPGPPPpslplGGSVAPGGDVRRRPPSRSPAAKPAAPAR--PPVRRL---ARPAVS--RSTESFALP--PDQPERPPQP 2911

                  ....*..
gi 223633935  399 DSLPRPQ 405
Cdd:PHA03247 2912 QAPPPPQ 2918
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
212-426 1.86e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 43.82  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935 212 SPTSPFREGRPGEWRTPAArgPRSGDPGPGPSHPAQPKAPRFPSNIIVTNGAAREPrrtlSRAAVSVQERRAQVLATiHG 291
Cdd:PRK07764 599 GPPAPASSGPPEEAARPAA--PAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEH----HPKHVAVPDASDGGDGW-PA 671
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935 292 HAGAFPAAGDAGEGAPGGGSSPERVARGRGLPGPAESLRAGGQAPRGPAlangfPSAHEALKSAPSSFAPAGKSLCFRPG 371
Cdd:PRK07764 672 KAGGAAPAAPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPAAQ-----PPQAAQGASAPSPAADDPVPLPPEPD 746
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 223633935 372 PALPSTRARQSFPGPRQPNGAQDWRRADSLPRPQ--GITVQFAGRGSSEEARREALR 426
Cdd:PRK07764 747 DPPDPAGAPAQPPPPPAPAPAAAPAAAPPPSPPSeeEEMAEDDAPSMDDEDRRDAEE 803
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
232-428 2.30e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 40.24  E-value: 2.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935 232 GPRSGDPGPgPSHPAQPKAPRFPSNIIVTNGAAREPRRTLSRAAVSVQERRAQVLATIHGHAGAFPAAGDAGEGAPGGGS 311
Cdd:PRK12323 366 GQSGGGAGP-ATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGP 444
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 223633935 312 SPERVARGRGLPGPAESLRAGGQAPRGPALANGFPSAHEAlKSAPSSFAPAGKSLCFRPGPALPSTRARQSFPGPRQPNG 391
Cdd:PRK12323 445 GGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAA-PAAAPAPADDDPPPWEELPPEFASPAPAQPDAAPAGWVA 523
                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 223633935 392 AQDWRRADSLPRPQGITVQFAGRGSSEEARREALRKL 428
Cdd:PRK12323 524 ESIPDPATADPDDAFETLAPAPAAAPAPRAAAATEPV 560
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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