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Conserved domains on  [gi|23943820|ref|NP_705730|]
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paired immunoglobulin-like type 2 receptor alpha precursor [Mus musculus]

Protein Classification

immunoglobulin domain-containing family protein( domain architecture ID 34076)

immunoglobulin (Ig) domain-containing family protein is a member of a large superfamily containing cell surface antigen receptors, co-receptors and co-stimulatory molecules of the immune system, molecules involved in antigen presentation to lymphocytes, cell adhesion molecules, certain cytokine receptors and intracellular muscle proteins; immunoglobulin domains are typically divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 40-156 8.88e-06

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05712:

Pssm-ID: 472250  Cd Length: 119  Bit Score: 44.30  E-value: 8.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943820  40 FGVNQPESCSGVQGGSIDIPFSFYFPWKLakdpqmsiaWRWKDFHGEFIYNSSLPF-------------IHEHFKGRLIL 106
Cdd:cd05712   1 WGLQMPKSVTVQEGLCVLIPCSFSYPADY---------WVSNPVHGYWYRGGPYPKyrppvatnnrtreVHESTQGRFRL 71

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 23943820 107 NWTQGQTSGVLRILNLKESDQTRYFGRVflQTTEGIQFWQSIPGTQLNVT 156
Cdd:cd05712  72 LGDPGKKNCSLSISDARPEDSGKYFFRV--ERGDSNKYSYLSNQLSLTVT 119
PiuB super family cl43805
PepSY-associated TM region [Function unknown];
198-235 4.23e-03

PepSY-associated TM region [Function unknown];


The actual alignment was detected with superfamily member COG3182:

Pssm-ID: 442415 [Multi-domain]  Cd Length: 379  Bit Score: 38.41  E-value: 4.23e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 23943820 198 GLATAAAVFLVGVLGLIVF-----LWWKRRRQGQKTKAEIPAR 235
Cdd:COG3182 331 GLPGRILYFLLGLALALLIvtgllLWWKRRRKKRAPPAARAPR 373
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 40-156 8.88e-06

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 44.30  E-value: 8.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943820  40 FGVNQPESCSGVQGGSIDIPFSFYFPWKLakdpqmsiaWRWKDFHGEFIYNSSLPF-------------IHEHFKGRLIL 106
Cdd:cd05712   1 WGLQMPKSVTVQEGLCVLIPCSFSYPADY---------WVSNPVHGYWYRGGPYPKyrppvatnnrtreVHESTQGRFRL 71

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 23943820 107 NWTQGQTSGVLRILNLKESDQTRYFGRVflQTTEGIQFWQSIPGTQLNVT 156
Cdd:cd05712  72 LGDPGKKNCSLSISDARPEDSGKYFFRV--ERGDSNKYSYLSNQLSLTVT 119
PiuB COG3182
PepSY-associated TM region [Function unknown];
198-235 4.23e-03

PepSY-associated TM region [Function unknown];


Pssm-ID: 442415 [Multi-domain]  Cd Length: 379  Bit Score: 38.41  E-value: 4.23e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 23943820 198 GLATAAAVFLVGVLGLIVF-----LWWKRRRQGQKTKAEIPAR 235
Cdd:COG3182 331 GLPGRILYFLLGLALALLIvtgllLWWKRRRKKRAPPAARAPR 373
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 44-156 4.23e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 36.28  E-value: 4.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943820    44 QPESCSGVQGGSIDIPFSFyfpWKLAKDPQMSIAW-RWKDFHGE----FIYNSSLPfiHEHFKGRLILNWTQGQTSGVLR 118
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTY---SSSMSEASTSVYWyRQPPGKGPtfliAYYSNGSE--EGVKKGRFSGRGDPSNGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 23943820   119 ILNLKESDQTRYFGRVFlqtTEGIQFWQSipGTQLNVT 156
Cdd:pfam07686  77 IQNLTLSDSGTYTCAVI---PSGEGVFGK--GTRLTVL 109
 
Name Accession Description Interval E-value
IgV_CD33 cd05712
Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic ...
 40-156 8.88e-06

Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins); The members here are composed of the immunoglobulin (Ig) domain at the N-terminus of Cluster of Differentiation (CD) 33 and related Siglecs (sialic acid-binding Ig-like lectins). Siglec refers to a structurally related protein family that specifically recognizes sialic acid in oligosaccharide chains of glycoproteins and glycolipids. Siglecs are type I transmembrane proteins, organized as an extracellular module composed of Ig-like domains, an N-terminal variable set of Ig-like carbohydrate recognition domains, and 1 to 16 constant Ig-like domains, followed by transmembrane and short cytoplasmic domains. Human Siglecs are classified into two subgroups, one subgroup is comprised of sialoadhesin (Siglec-1), CD22 (Siglec-2), and MAG, the other subgroup is comprised of CD33-related Siglecs which include CD33 (Siglec-3) and human Siglecs 5-11.


Pssm-ID: 409377  Cd Length: 119  Bit Score: 44.30  E-value: 8.88e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943820  40 FGVNQPESCSGVQGGSIDIPFSFYFPWKLakdpqmsiaWRWKDFHGEFIYNSSLPF-------------IHEHFKGRLIL 106
Cdd:cd05712   1 WGLQMPKSVTVQEGLCVLIPCSFSYPADY---------WVSNPVHGYWYRGGPYPKyrppvatnnrtreVHESTQGRFRL 71

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 23943820 107 NWTQGQTSGVLRILNLKESDQTRYFGRVflQTTEGIQFWQSIPGTQLNVT 156
Cdd:cd05712  72 LGDPGKKNCSLSISDARPEDSGKYFFRV--ERGDSNKYSYLSNQLSLTVT 119
PiuB COG3182
PepSY-associated TM region [Function unknown];
198-235 4.23e-03

PepSY-associated TM region [Function unknown];


Pssm-ID: 442415 [Multi-domain]  Cd Length: 379  Bit Score: 38.41  E-value: 4.23e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|...
gi 23943820 198 GLATAAAVFLVGVLGLIVF-----LWWKRRRQGQKTKAEIPAR 235
Cdd:COG3182 331 GLPGRILYFLLGLALALLIvtgllLWWKRRRKKRAPPAARAPR 373
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 44-156 4.23e-03

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 36.28  E-value: 4.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 23943820    44 QPESCSGVQGGSIDIPFSFyfpWKLAKDPQMSIAW-RWKDFHGE----FIYNSSLPfiHEHFKGRLILNWTQGQTSGVLR 118
Cdd:pfam07686   2 TPREVTVALGGSVTLPCTY---SSSMSEASTSVYWyRQPPGKGPtfliAYYSNGSE--EGVKKGRFSGRGDPSNGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 23943820   119 ILNLKESDQTRYFGRVFlqtTEGIQFWQSipGTQLNVT 156
Cdd:pfam07686  77 IQNLTLSDSGTYTCAVI---PSGEGVFGK--GTRLTVL 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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