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Conserved domains on  [gi|28571499|ref|NP_730822|]
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sideroflexin 1/3, isoform B [Drosophila melanogaster]

Protein Classification

sideroflexin family transporter( domain architecture ID 10510848)

sideroflexin family transporter is a mitochondrial membrane protein implicated in one-carbon metabolism; similar to sideroflexin-1, which acts as a mitochondrial serine transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Mtc pfam03820
Tricarboxylate carrier;
8-321 0e+00

Tricarboxylate carrier;


:

Pssm-ID: 427526  Cd Length: 319  Bit Score: 512.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499     8 NIDEPKYDQNSYLGRAKHFFLLTNPLNVLASASKLEEARQIVIKYRAGKdVPECKTIDDVWRAKYLYDSAFHPETGEKQI 87
Cdd:pfam03820   1 DLDKPRWDQSTYWGRLKHFFDITDPRTLLASDAELEEAKELVDDYKKGK-EPPGTTEEELWRAKKLYDSAFHPDTGEKIF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499    88 VIGRMAAQMPMNTIITGGMMAFYKSTPAVVFWQWFNQTFNAIVNYTNRSGTSPISQQQLVTSYCLATSGALVTALSLNHA 167
Cdd:pfam03820  80 LPFRMSAQVPMNMPITGGMLTPYKSTPAVIFWQWANQSFNAAVNYANRNASSPISTSQLAQAYVAAVTAACGVALGLNSL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499   168 VK------NMNPLLGRLVPLVAVGAANCINIPCMRMQELRNGVTLFDEHSNEMGISKKAAVVGISTVILSRIAMAIPGMT 241
Cdd:pfam03820 160 VKrlklspATRLLLGRLVPFAAVAAANCVNIPLMRSKELRNGIDVFDEDGNVVGKSKKAAKKAVGQVALSRVLMAAPGMV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499   242 LTPVLMNVLEKRGFLAKYPRSNAPIQTLFCGFVLIFATPLGCAFFKQRADIKVDSLESEVRDSIRKKRPELETVWFNKGL 321
Cdd:pfam03820 240 LPPLIMNRLEKTGFLKRRPWLHAPIQLGLIGLCLGFALPLACALFPQRSSISVSKLEPEFQELIKKKGGPPTTVYFNKGL 319
 
Name Accession Description Interval E-value
Mtc pfam03820
Tricarboxylate carrier;
8-321 0e+00

Tricarboxylate carrier;


Pssm-ID: 427526  Cd Length: 319  Bit Score: 512.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499     8 NIDEPKYDQNSYLGRAKHFFLLTNPLNVLASASKLEEARQIVIKYRAGKdVPECKTIDDVWRAKYLYDSAFHPETGEKQI 87
Cdd:pfam03820   1 DLDKPRWDQSTYWGRLKHFFDITDPRTLLASDAELEEAKELVDDYKKGK-EPPGTTEEELWRAKKLYDSAFHPDTGEKIF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499    88 VIGRMAAQMPMNTIITGGMMAFYKSTPAVVFWQWFNQTFNAIVNYTNRSGTSPISQQQLVTSYCLATSGALVTALSLNHA 167
Cdd:pfam03820  80 LPFRMSAQVPMNMPITGGMLTPYKSTPAVIFWQWANQSFNAAVNYANRNASSPISTSQLAQAYVAAVTAACGVALGLNSL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499   168 VK------NMNPLLGRLVPLVAVGAANCINIPCMRMQELRNGVTLFDEHSNEMGISKKAAVVGISTVILSRIAMAIPGMT 241
Cdd:pfam03820 160 VKrlklspATRLLLGRLVPFAAVAAANCVNIPLMRSKELRNGIDVFDEDGNVVGKSKKAAKKAVGQVALSRVLMAAPGMV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499   242 LTPVLMNVLEKRGFLAKYPRSNAPIQTLFCGFVLIFATPLGCAFFKQRADIKVDSLESEVRDSIRKKRPELETVWFNKGL 321
Cdd:pfam03820 240 LPPLIMNRLEKTGFLKRRPWLHAPIQLGLIGLCLGFALPLACALFPQRSSISVSKLEPEFQELIKKKGGPPTTVYFNKGL 319
mtc TIGR00798
tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from ...
5-321 6.15e-151

tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from eukaryotes. A single member of the family has been functionally characterized, the tricarboxylate carrier from rat liver mitochondria. The rat liver mitochondrial tricarboxylate carrier has been reported to transport citrate, cis-aconitate, threo-D-isocitrate, D- and L-tartrate, malate, succinate and phosphoenolpyruvate. It presumably functions by a proton symport mechanism. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129880  Cd Length: 318  Bit Score: 426.01  E-value: 6.15e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499     5 PRVNIDEPKYDQNSYLGRAKHFFLLTNPLNVLASASKLEEARQIVIKYRAGKDVPEckTIDDVWRAKYLYDSAFHPETGE 84
Cdd:TIGR00798   1 PTFDISKPRWDQSTFLGRARHFFEITNPLTLFSSEKQLEKAREIVEDYKAGKASPL--TVDELWRAKKLYDSAFHPDTGE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499    85 KQIVIGRMAAQMPMNTIITGGMMAFYKSTPAVVFWQWFNQTFNAIVNYTNRSGTSPISQQQLVTSYCLATSGALVTALSL 164
Cdd:TIGR00798  79 KMFLPGRMSAQVPMNMVITGGMLTPYRSTPGVVFWQWINQSFNAAVNYTNRSGDSPLTLSQLLVSYCAAVTGACGVALGL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499   165 NHAVKNMN---PLLGRLVPLVAVGAANCINIPCMRMQELRNGVTLFDEHSNEMGISKKAAVVGISTVILSRIAMAIPGMT 241
Cdd:TIGR00798 159 NMMVKKSPslsPLIGRLVPFAAVAVANAINIPMMRGNELTEGIEVFDEDGETVGKSKKAAALAIAQVVLSRVIMAVPDMV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499   242 LTPVLMNVLEKRGFLAKYPRSNAPIQTLFCGFVLIFATPLGCAFFKQRADIKVDSLESEVRDSIRKKRPELETVWFNKGL 321
Cdd:TIGR00798 239 MPPLIMNRLERTAWLRARPWMQIPIQTLLCGLGLAFATPLACALFPQKSAISVDKLEPSLQNLIQKLGNPPKVVYYNKGL 318
 
Name Accession Description Interval E-value
Mtc pfam03820
Tricarboxylate carrier;
8-321 0e+00

Tricarboxylate carrier;


Pssm-ID: 427526  Cd Length: 319  Bit Score: 512.44  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499     8 NIDEPKYDQNSYLGRAKHFFLLTNPLNVLASASKLEEARQIVIKYRAGKdVPECKTIDDVWRAKYLYDSAFHPETGEKQI 87
Cdd:pfam03820   1 DLDKPRWDQSTYWGRLKHFFDITDPRTLLASDAELEEAKELVDDYKKGK-EPPGTTEEELWRAKKLYDSAFHPDTGEKIF 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499    88 VIGRMAAQMPMNTIITGGMMAFYKSTPAVVFWQWFNQTFNAIVNYTNRSGTSPISQQQLVTSYCLATSGALVTALSLNHA 167
Cdd:pfam03820  80 LPFRMSAQVPMNMPITGGMLTPYKSTPAVIFWQWANQSFNAAVNYANRNASSPISTSQLAQAYVAAVTAACGVALGLNSL 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499   168 VK------NMNPLLGRLVPLVAVGAANCINIPCMRMQELRNGVTLFDEHSNEMGISKKAAVVGISTVILSRIAMAIPGMT 241
Cdd:pfam03820 160 VKrlklspATRLLLGRLVPFAAVAAANCVNIPLMRSKELRNGIDVFDEDGNVVGKSKKAAKKAVGQVALSRVLMAAPGMV 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499   242 LTPVLMNVLEKRGFLAKYPRSNAPIQTLFCGFVLIFATPLGCAFFKQRADIKVDSLESEVRDSIRKKRPELETVWFNKGL 321
Cdd:pfam03820 240 LPPLIMNRLEKTGFLKRRPWLHAPIQLGLIGLCLGFALPLACALFPQRSSISVSKLEPEFQELIKKKGGPPTTVYFNKGL 319
mtc TIGR00798
tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from ...
5-321 6.15e-151

tricarboxylate carrier; The MTC family consists of a limited number of homologues, all from eukaryotes. A single member of the family has been functionally characterized, the tricarboxylate carrier from rat liver mitochondria. The rat liver mitochondrial tricarboxylate carrier has been reported to transport citrate, cis-aconitate, threo-D-isocitrate, D- and L-tartrate, malate, succinate and phosphoenolpyruvate. It presumably functions by a proton symport mechanism. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 129880  Cd Length: 318  Bit Score: 426.01  E-value: 6.15e-151
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499     5 PRVNIDEPKYDQNSYLGRAKHFFLLTNPLNVLASASKLEEARQIVIKYRAGKDVPEckTIDDVWRAKYLYDSAFHPETGE 84
Cdd:TIGR00798   1 PTFDISKPRWDQSTFLGRARHFFEITNPLTLFSSEKQLEKAREIVEDYKAGKASPL--TVDELWRAKKLYDSAFHPDTGE 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499    85 KQIVIGRMAAQMPMNTIITGGMMAFYKSTPAVVFWQWFNQTFNAIVNYTNRSGTSPISQQQLVTSYCLATSGALVTALSL 164
Cdd:TIGR00798  79 KMFLPGRMSAQVPMNMVITGGMLTPYRSTPGVVFWQWINQSFNAAVNYTNRSGDSPLTLSQLLVSYCAAVTGACGVALGL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499   165 NHAVKNMN---PLLGRLVPLVAVGAANCINIPCMRMQELRNGVTLFDEHSNEMGISKKAAVVGISTVILSRIAMAIPGMT 241
Cdd:TIGR00798 159 NMMVKKSPslsPLIGRLVPFAAVAVANAINIPMMRGNELTEGIEVFDEDGETVGKSKKAAALAIAQVVLSRVIMAVPDMV 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28571499   242 LTPVLMNVLEKRGFLAKYPRSNAPIQTLFCGFVLIFATPLGCAFFKQRADIKVDSLESEVRDSIRKKRPELETVWFNKGL 321
Cdd:TIGR00798 239 MPPLIMNRLERTAWLRARPWMQIPIQTLLCGLGLAFATPLACALFPQKSAISVDKLEPSLQNLIQKLGNPPKVVYYNKGL 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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