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Conserved domains on  [gi|25286711|ref|NP_742047|]
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CMRF35-like molecule 2 precursor [Mus musculus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10146027)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to polymeric immunoglobulin receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 18-126 4.05e-25

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


:

Pssm-ID: 409381  Cd Length: 100  Bit Score: 93.62  E-value: 4.05e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25286711  18 LTGPGSVSGYVGGSLRVQCQYSPSYKGYMKYWCRGPhDTTCKTIVETDGSEKEKRsgpVSIRDHASNSTITVIMEDLSED 97
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWG-SEGCQTLVSSEGVVPGGR---ISLTDDPDNGVFTVTLNQLRKE 76

                        90       100
                ....*....|....*....|....*....
gi 25286711  98 NAGSYWCKiqtsfIWDSWSRDPSVSVRVN 126
Cdd:cd05716  77 DAGWYWCG-----VGDDGDRGLTVQVKLV 100
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 18-126 4.05e-25

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 93.62  E-value: 4.05e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25286711  18 LTGPGSVSGYVGGSLRVQCQYSPSYKGYMKYWCRGPhDTTCKTIVETDGSEKEKRsgpVSIRDHASNSTITVIMEDLSED 97
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWG-SEGCQTLVSSEGVVPGGR---ISLTDDPDNGVFTVTLNQLRKE 76

                        90       100
                ....*....|....*....|....*....
gi 25286711  98 NAGSYWCKiqtsfIWDSWSRDPSVSVRVN 126
Cdd:cd05716  77 DAGWYWCG-----VGDDGDRGLTVQVKLV 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 19-124 1.66e-17

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 74.42  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25286711    19 TGPGSVSGYVGGSLRVQCQYSPSY--KGYMKYWCRGP--HDTTCKTIVETDGSEKEKRSGPVSIRDHASNSTITVIMEDL 94
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQPpgKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 25286711    95 SEDNAGSYWCKIQTSFIWDsWSRDPSVSVR 124
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGV-FGKGTRLTVL 109
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 21-109 6.63e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 34.40  E-value: 6.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25286711     21 PGSVSGYVGGSLRVQCQYSPSYKGYMkYWCRgphdttcktivetDGSEKEKRSGPVSIRDHASNSTITviMEDLSEDNAG 100
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEV-TWYK-------------QGGKLLAESGRFSVSRSGSTSTLT--ISNVTPEDSG 64


                   ....*....
gi 25286711    101 SYWCKIQTS 109
Cdd:smart00410  65 TYTCAATNS 73
 
Name Accession Description Interval E-value
IgV_pIgR_like cd05716
Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The ...
 18-126 4.05e-25

Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins; The members here are composed of the immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins. pIgR delivers dimeric IgA and pentameric IgM to mucosal secretions. Polymeric immunoglobulin (pIgs) are the first defense against pathogens and toxins. IgA and IgM can form polymers via an 18-residue extension at their C-termini referred to as the tailpiece. pIgR transports pIgs across mucosal epithelia into mucosal secretions. Human pIgR is a glycosylated type I transmembrane protein, comprised of a 620-residue extracellular region, a 23-residue transmembrane region, and a 103-residue cytoplasmic tail. The extracellular region contains five domains that share sequence similarity with Ig variable (v) regions. This group also contains the Ig-like extracellular domains of other receptors such as NK cell receptor Nkp44 and myeloid receptors, among others.


Pssm-ID: 409381  Cd Length: 100  Bit Score: 93.62  E-value: 4.05e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25286711  18 LTGPGSVSGYVGGSLRVQCQYSPSYKGYMKYWCRGPhDTTCKTIVETDGSEKEKRsgpVSIRDHASNSTITVIMEDLSED 97
Cdd:cd05716   1 SVGPEVVTGVEGGSVTIQCPYPPKYASSRKYWCKWG-SEGCQTLVSSEGVVPGGR---ISLTDDPDNGVFTVTLNQLRKE 76

                        90       100
                ....*....|....*....|....*....
gi 25286711  98 NAGSYWCKiqtsfIWDSWSRDPSVSVRVN 126
Cdd:cd05716  77 DAGWYWCG-----VGDDGDRGLTVQVKLV 100
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 19-124 1.66e-17

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 74.42  E-value: 1.66e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25286711    19 TGPGSVSGYVGGSLRVQCQYSPSY--KGYMKYWCRGP--HDTTCKTIVETDGSEKEKRSGPVSIRDHASNSTITVIMEDL 94
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYSSSMseASTSVYWYRQPpgKGPTFLIAYYSNGSEEGVKKGRFSGRGDPSNGDGSLTIQNL 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 25286711    95 SEDNAGSYWCKIQTSFIWDsWSRDPSVSVR 124
Cdd:pfam07686  81 TLSDSGTYTCAVIPSGEGV-FGKGTRLTVL 109
IgV_TIM-3_like cd20982
Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3) ...
 23-107 4.37e-03

Immunoglobulin Variable (IgV) domain of T cell Immunoglobulin Domain and Mucin Domain 3 (Tim-3), and similar domains; The members here are composed of the immunoglobulin variable (IgV) domain of T cell immunoglobulin domain and mucin domain 3 (Tim-3; also known as Hepatitis A virus cellular receptor 2 (HAVcr-2) and Cluster of Differentiation 366 (CD366)) and similar proteins. TIM-3 is a checkpoint inhibitor in immune responses to tumors, as well as involved in chronic viral infections. Thus, Tim-3 has emerged as one of most promising immune checkpoint targets for cancer immunotherapy. Tim-3 is highly expressed on Th1 lymphocytes and CD11b(+) macrophages and is upregulated on activated T and myeloid cells. TIM-3 regulates macrophage, activation and inhibits Th1 mediated immune responses to promote immunological tolerance. There are three TIM family members in humans (TIM-1, TIM-3, and TIM-4) and eight members in mice (TIM-1 to TIM-8). The IgV domain of human TIM-3 has been shown to bind ligands such as carcinoembryonic antigen cell adhesion molecule 1 (CEACAM1), high mobility group protein B1 (HMGB1)and galectin-9 (GAL9). The binding of GAL9 to TIM-3 can negatively regulate Th1 immune response, enhance immune tolerance and inhibit anti#tumor immunity. Dysregulation of the TIM-3/GAL9 pathway is implicated in numerous chronic autoimmune diseases, such as multiple sclerosis and systemic lupus erythematosus.


Pssm-ID: 409574  Cd Length: 107  Bit Score: 35.51  E-value: 4.37e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25286711  23 SVSGYVGGSLRVQCQYSPSYKGYMKYWCRG----PHDTTCKTIVETDGSE-KEKRSGPVSIRDHASNSTITVIMEDLSED 97
Cdd:cd20982   2 EYRAEVGHNAYLPCSYTTAAPGNLVPVCWGkgacPVSYCGNVLLRTDERDvTYQKSSRYQLKGDFSKGDVSLTIENVTLA 81

                        90
                ....*....|
gi 25286711  98 NAGSYWCKIQ 107
Cdd:cd20982  82 DSGIYCCRIQ 91
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 21-109 6.63e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 34.40  E-value: 6.63e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 25286711     21 PGSVSGYVGGSLRVQCQYSPSYKGYMkYWCRgphdttcktivetDGSEKEKRSGPVSIRDHASNSTITviMEDLSEDNAG 100
Cdd:smart00410   1 PPSVTVKEGESVTLSCEASGSPPPEV-TWYK-------------QGGKLLAESGRFSVSRSGSTSTLT--ISNVTPEDSG 64


                   ....*....
gi 25286711    101 SYWCKIQTS 109
Cdd:smart00410  65 TYTCAATNS 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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