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Conserved domains on  [gi|26024319|ref|NP_742154|]
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NF-kappa-B inhibitor delta [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 11429852)

ankyrin repeat (ANK) domain-containing protein is involved in mediating protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  33435370|17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
46-317 5.94e-23

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.56  E-value: 5.94e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  46 AHILALGPQQLLAQDEEGDTLLHLFAARGLRwaAYAAAEVLQMYRQLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEP 125
Cdd:COG0666  36 LLLLLLLALLALALADALGALLLLAAALAGD--LLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADV 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319 126 NATDHQGRSVLHVAATYGLPGVLSAVFKSGIqvDLEARDFEGLTPLHTAVlalnaamlpasvcprmqnsqARDRLTCVQM 205
Cdd:COG0666 114 NARDKDGETPLHLAAYNGNLEIVKLLLEAGA--DVNAQDNDGNTPLHLAA--------------------ANGNLEIVKL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319 206 LLQMGASHTSQEiKSNKTILHLAVQAANPTLVQLLLglprgDLRAFVNMK-AHGNTALHMAAALppgpPQEAIVRHLLAA 284
Cdd:COG0666 172 LLEAGADVNARD-NDGETPLHLAAENGHLEIVKLLL-----EAGADVNAKdNDGKTALDLAAEN----GNLEIVKLLLEA 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 26024319 285 GADPTLRNLENEQPVHLLRPGPGPEGLRQLLKR 317
Cdd:COG0666 242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
46-317 5.94e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.56  E-value: 5.94e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  46 AHILALGPQQLLAQDEEGDTLLHLFAARGLRwaAYAAAEVLQMYRQLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEP 125
Cdd:COG0666  36 LLLLLLLALLALALADALGALLLLAAALAGD--LLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADV 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319 126 NATDHQGRSVLHVAATYGLPGVLSAVFKSGIqvDLEARDFEGLTPLHTAVlalnaamlpasvcprmqnsqARDRLTCVQM 205
Cdd:COG0666 114 NARDKDGETPLHLAAYNGNLEIVKLLLEAGA--DVNAQDNDGNTPLHLAA--------------------ANGNLEIVKL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319 206 LLQMGASHTSQEiKSNKTILHLAVQAANPTLVQLLLglprgDLRAFVNMK-AHGNTALHMAAALppgpPQEAIVRHLLAA 284
Cdd:COG0666 172 LLEAGADVNARD-NDGETPLHLAAENGHLEIVKLLL-----EAGADVNAKdNDGKTALDLAAEN----GNLEIVKLLLEA 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 26024319 285 GADPTLRNLENEQPVHLLRPGPGPEGLRQLLKR 317
Cdd:COG0666 242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
Ank_2 pfam12796
Ankyrin repeats (3 copies);
200-292 7.83e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 7.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   200 LTCVQMLLQMGASHTSQEiKSNKTILHLAVQAANPTLVQLLLGlprgdlRAFVNMKAHGNTALHMAAALppGppQEAIVR 279
Cdd:pfam12796  10 LELVKLLLENGADANLQD-KNGRTALHLAAKNGHLEIVKLLLE------HADVNLKDNGRTALHYAARS--G--HLEIVK 78

                          90
                  ....*....|...
gi 26024319   280 HLLAAGADPTLRN 292
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 60-301 6.35e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.96  E-value: 6.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   60 DEEGDTLLHLFaargLRWAAYAAAEVLQMYRQ----LDIREHKGKTPL-LVAAAANQPLIVEDLLSLGAEPNATDHQGRS 134
Cdd:PHA03095  44 GEYGKTPLHLY----LHYSSEKVKDIVRLLLEagadVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRT 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  135 VLHVAATyGL---PGVLSAVFKSGIqvDLEARDFEGLTPLHtaVLalnaamlpasvcprMQNSQARDRLtcVQMLLQMGA 211
Cdd:PHA03095 120 PLHVYLS-GFninPKVIRLLLRKGA--DVNALDLYGMTPLA--VL--------------LKSRNANVEL--LRLLIDAGA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  212 SHTSQEIkSNKTILHLAVQA--ANPTLVQLLLGlpRGDLRAFVNMkaHGNTALHMAAALppGPPQEAIVRHLLAAGADPT 289
Cdd:PHA03095 179 DVYAVDD-RFRSLLHHHLQSfkPRARIVRELIR--AGCDPAATDM--LGNTPLHSMATG--SSCKRSLVLPLLIAGISIN 251

                        250
                 ....*....|..
gi 26024319  290 LRNLENEQPVHL 301
Cdd:PHA03095 252 ARNRYGQTPLHY 263
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 63-241 1.47e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.38  E-value: 1.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  63 GDTLLHLFAARGLRWAAYAAAEV------LQMYRQLdireHKGKTPLLVAAAANQPLIVEDLLSLGAE---PNATD---- 129
Cdd:cd22192  51 GETALHVAALYDNLEAAVVLMEAapelvnEPMTSDL----YQGETALHIAVVNQNLNLVRELIARGADvvsPRATGtffr 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319 130 -------HQGRSVLHVAATYGLPGVLSAVFKSGiqVDLEARDFEGLTPLHTAVLALNAamlpASVCpRMQN----SQARD 198
Cdd:cd22192 127 pgpknliYYGEHPLSFAACVGNEEIVRLLIEHG--ADIRAQDSLGNTVLHILVLQPNK----TFAC-QMYDlilsYDKED 199

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 26024319 199 RLTCVQMLL-QMGAshtsqeiksnkTILHLAVQAANPTLVQLLL 241
Cdd:cd22192 200 DLQPLDLVPnNQGL-----------TPFKLAAKEGNIVMFQHLV 232
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
46-317 5.94e-23

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 96.56  E-value: 5.94e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  46 AHILALGPQQLLAQDEEGDTLLHLFAARGLRwaAYAAAEVLQMYRQLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEP 125
Cdd:COG0666  36 LLLLLLLALLALALADALGALLLLAAALAGD--LLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADV 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319 126 NATDHQGRSVLHVAATYGLPGVLSAVFKSGIqvDLEARDFEGLTPLHTAVlalnaamlpasvcprmqnsqARDRLTCVQM 205
Cdd:COG0666 114 NARDKDGETPLHLAAYNGNLEIVKLLLEAGA--DVNAQDNDGNTPLHLAA--------------------ANGNLEIVKL 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319 206 LLQMGASHTSQEiKSNKTILHLAVQAANPTLVQLLLglprgDLRAFVNMK-AHGNTALHMAAALppgpPQEAIVRHLLAA 284
Cdd:COG0666 172 LLEAGADVNARD-NDGETPLHLAAENGHLEIVKLLL-----EAGADVNAKdNDGKTALDLAAEN----GNLEIVKLLLEA 241

                       250       260       270
                ....*....|....*....|....*....|...
gi 26024319 285 GADPTLRNLENEQPVHLLRPGPGPEGLRQLLKR 317
Cdd:COG0666 242 GADLNAKDKDGLTALLLAAAAGAALIVKLLLLA 274
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
41-296 2.41e-17

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 80.77  E-value: 2.41e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  41 LETARAHILALGPQQLLAQDEEGDTLLHLFAARG----LRWAAYAAAEVlqmyrqlDIREHKGKTPLLVAAAANQPLIVE 116
Cdd:COG0666  65 GDLLVALLLLAAGADINAKDDGGNTLLHAAARNGdleiVKLLLEAGADV-------NARDKDGETPLHLAAYNGNLEIVK 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319 117 DLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGiqVDLEARDFEGLTPLHTAVlalnaamlpasvcprmqnsqA 196
Cdd:COG0666 138 LLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAG--ADVNARDNDGETPLHLAA--------------------E 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319 197 RDRLTCVQMLLQMGASHTSQEiKSNKTILHLAVQAANPTLVQLLLGLPRGDLRAfvnmKAHGNTALHMAAALppgpPQEA 276
Cdd:COG0666 196 NGHLEIVKLLLEAGADVNAKD-NDGKTALDLAAENGNLEIVKLLLEAGADLNAK----DKDGLTALLLAAAA----GAAL 266

                       250       260
                ....*....|....*....|
gi 26024319 277 IVRHLLAAGADPTLRNLENE 296
Cdd:COG0666 267 IVKLLLLALLLLAAALLDLL 286
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
101-317 9.67e-13

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 67.67  E-value: 9.67e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319 101 TPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIqvDLEARDFEGLTPLHTAVLALNA 180
Cdd:COG0666  23 LLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA--DINAKDDGGNTLLHAAARNGDL 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319 181 AML------PASVCPRMQNSQ-------ARDRLTCVQMLLQMGASHTSQEiKSNKTILHLAVQAANPTLVQLLLglprgD 247
Cdd:COG0666 101 EIVkllleaGADVNARDKDGEtplhlaaYNGNLEIVKLLLEAGADVNAQD-NDGNTPLHLAAANGNLEIVKLLL-----E 174

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26024319 248 LRAFVNMK-AHGNTALHMAAALppgpPQEAIVRHLLAAGADPTLRNLENEQPVHLLRPGPGPEGLRQLLKR 317
Cdd:COG0666 175 AGADVNARdNDGETPLHLAAEN----GHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEA 241
Ank_2 pfam12796
Ankyrin repeats (3 copies);
200-292 7.83e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 55.12  E-value: 7.83e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   200 LTCVQMLLQMGASHTSQEiKSNKTILHLAVQAANPTLVQLLLGlprgdlRAFVNMKAHGNTALHMAAALppGppQEAIVR 279
Cdd:pfam12796  10 LELVKLLLENGADANLQD-KNGRTALHLAAKNGHLEIVKLLLE------HADVNLKDNGRTALHYAARS--G--HLEIVK 78

                          90
                  ....*....|...
gi 26024319   280 HLLAAGADPTLRN 292
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03095 PHA03095
ankyrin-like protein; Provisional
 60-301 6.35e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 56.96  E-value: 6.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   60 DEEGDTLLHLFaargLRWAAYAAAEVLQMYRQ----LDIREHKGKTPL-LVAAAANQPLIVEDLLSLGAEPNATDHQGRS 134
Cdd:PHA03095  44 GEYGKTPLHLY----LHYSSEKVKDIVRLLLEagadVNAPERCGFTPLhLYLYNATTLDVIKLLIKAGADVNAKDKVGRT 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  135 VLHVAATyGL---PGVLSAVFKSGIqvDLEARDFEGLTPLHtaVLalnaamlpasvcprMQNSQARDRLtcVQMLLQMGA 211
Cdd:PHA03095 120 PLHVYLS-GFninPKVIRLLLRKGA--DVNALDLYGMTPLA--VL--------------LKSRNANVEL--LRLLIDAGA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  212 SHTSQEIkSNKTILHLAVQA--ANPTLVQLLLGlpRGDLRAFVNMkaHGNTALHMAAALppGPPQEAIVRHLLAAGADPT 289
Cdd:PHA03095 179 DVYAVDD-RFRSLLHHHLQSfkPRARIVRELIR--AGCDPAATDM--LGNTPLHSMATG--SSCKRSLVLPLLIAGISIN 251

                        250
                 ....*....|..
gi 26024319  290 LRNLENEQPVHL 301
Cdd:PHA03095 252 ARNRYGQTPLHY 263
Ank_2 pfam12796
Ankyrin repeats (3 copies);
103-216 1.08e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 51.66  E-value: 1.08e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   103 LLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKsgiQVDLEARDfEGLTPLHTAVLAlnaam 182
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE---HADVNLKD-NGRTALHYAARS----- 71

                          90       100       110
                  ....*....|....*....|....*....|....
gi 26024319   183 lpasvcprmqnsqarDRLTCVQMLLQMGASHTSQ 216
Cdd:pfam12796  72 ---------------GHLEIVKLLLEKGADINVK 90
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 98-299 1.09e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 53.14  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   98 KGKTPL-LVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYG-LPGVLSAVFKSGIQVDleARDFEGLTPLHTAV 175
Cdd:PHA02876 306 KGETPLyLMAKNGYDTENIRTLIMLGADVNAADRLYITPLHQASTLDrNKDIVITLLELGANVN--ARDYCDKTPIHYAA 383

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  176 LalnaamlpasvcprmqnsqaRDRLTCVQMLLQMGA--SHTSQEIksnKTILHLAVQAANP-TLVQLLLglprgDLRAFV 252
Cdd:PHA02876 384 V--------------------RNNVVIINTLLDYGAdiEALSQKI---GTALHFALCGTNPyMSVKTLI-----DRGANV 435

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 26024319  253 NMK-AHGNTALHMAAALPPGPpqeAIVRHLLAAGADPTLRNLENEQPV 299
Cdd:PHA02876 436 NSKnKDLSTPLHYACKKNCKL---DVIEMLLDNGADVNAINIQNQYPL 480
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 96-241 1.09e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 1.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   96 EHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDleARDFEGLTPLHTAV 175
Cdd:PHA02878 165 RHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTD--ARDKCGNTPLHISV 242

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26024319  176 lalnAAMLPASVcprmqnsqardrltcVQMLLQMGASHTSQEIKSNKTILHLAVQaaNPTLVQLLL 241
Cdd:PHA02878 243 ----GYCKDYDI---------------LKLLLEHGVDVNAKSYILGLTALHSSIK--SERKLKLLL 287
PHA03095 PHA03095
ankyrin-like protein; Provisional
 99-299 2.72e-07

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 51.95  E-value: 2.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   99 GKTPL---LVAAAANqPLIVEDLLSLGAEPNATDHQGRSVLHV-----AATyglPGVLSAVFKSGiqVDLEARDFEGLTP 170
Cdd:PHA03095 117 GRTPLhvyLSGFNIN-PKVIRLLLRKGADVNALDLYGMTPLAVllksrNAN---VELLRLLIDAG--ADVYAVDDRFRSL 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  171 LHtaVLALNaamlpasvcprmqnsqARDRLTCVQMLLQMGASHTSQEIKSNkTILHLAV---QAANPTLVQLLLGlprgd 247
Cdd:PHA03095 191 LH--HHLQS----------------FKPRARIVRELIRAGCDPAATDMLGN-TPLHSMAtgsSCKRSLVLPLLIA----- 246

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 26024319  248 lRAFVN-MKAHGNTALHMAAALppgpPQEAIVRHLLAAGADPTLRNLENEQPV 299
Cdd:PHA03095 247 -GISINaRNRYGQTPLHYAAVF----NNPRACRRLIALGADINAVSSDGNTPL 294
PHA03095 PHA03095
ankyrin-like protein; Provisional
 114-302 1.19e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 49.64  E-value: 1.19e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  114 IVEDLLSLGAEPNATDHQGRSVLHVAATYGLP---GVLSAVFKSGIQVDleARDFEGLTPLHTavLALNAAMLPAsvcpr 190
Cdd:PHA03095  29 EVRRLLAAGADVNFRGEYGKTPLHLYLHYSSEkvkDIVRLLLEAGADVN--APERCGFTPLHL--YLYNATTLDV----- 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  191 mqnsqardrltcVQMLLQMGAShTSQEIKSNKTILH--LAVQAANPTLVQLLL--GLPRGDLRAF--------------- 251
Cdd:PHA03095 100 ------------IKLLIKAGAD-VNAKDKVGRTPLHvyLSGFNINPKVIRLLLrkGADVNALDLYgmtplavllksrnan 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 26024319  252 ---VNM-----------KAHGNTALHMAAALPPgpPQEAIVRHLLAAGADPTLRNLENEQPVHLL 302
Cdd:PHA03095 167 velLRLlidagadvyavDDRFRSLLHHHLQSFK--PRARIVRELIRAGCDPAATDMLGNTPLHSM 229
Ank_2 pfam12796
Ankyrin repeats (3 copies);
59-129 2.68e-06

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 45.11  E-value: 2.68e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 26024319    59 QDEEGDTLLHLFAARGlrwaAYAAAEVLQMYRQLDIREHkGKTPLLVAAAANQPLIVEDLLSLGAEPNATD 129
Cdd:pfam12796  26 QDKNGRTALHLAAKNG----HLEIVKLLLEHADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADINVKD 91
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 59-208 7.94e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.27  E-value: 7.94e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   59 QDEEGDTLLHLFAARGlrwaayaAAEVLQM---YR-QLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRS 134
Cdd:PHA02874 120 KDAELKTFLHYAIKKG-------DLESIKMlfeYGaDVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGES 192

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26024319  135 VLHVAATYGLPGVLSAVFKSGIQVDLEARDfeGLTPLHTAVLAlNAAMLPASVCPRMQNSQARDRLTCVQMLLQ 208
Cdd:PHA02874 193 PLHNAAEYGDYACIKLLIDHGNHIMNKCKN--GFTPLHNAIIH-NRSAIELLINNASINDQDIDGSTPLHHAIN 263
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 113-300 1.44e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 46.60  E-value: 1.44e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  113 LIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDLEARDfeGLTPLHTAVLALNAAMLPASVCPR-- 190
Cdd:PHA02876 159 LIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALD--DLSVLECAVDSKNIDTIKAIIDNRsn 236

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  191 -------MQNSQARDRLTCVQMLLQMGASHTSQEIKSNkTILHLAVQAanPTLVQLLLG-LPRGdlrAFVNMK-AHGNTA 261
Cdd:PHA02876 237 inkndlsLLKAIRNEDLETSLLLYDAGFSVNSIDDCKN-TPLHHASQA--PSLSRLVPKlLERG---ADVNAKnIKGETP 310

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 26024319  262 LHMAAAlpPGPPQEAIvRHLLAAGADPTLRNLENEQPVH 300
Cdd:PHA02876 311 LYLMAK--NGYDTENI-RTLIMLGADVNAADRLYITPLH 346
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 101-301 2.58e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 45.43  E-value: 2.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  101 TPLLVAAAANQPLIVEDLLSLGAEPN--ATDHQGRSVLHVAATYGLPGVLSAV---FKSGiqVDLEARDFEGLTPLHTAV 175
Cdd:PHA03100  37 LPLYLAKEARNIDVVKILLDNGADINssTKNNSTPLHYLSNIKYNLTDVKEIVkllLEYG--ANVNAPDNNGITPLLYAI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  176 lalnaamlpasvCPRMQNsqardrLTCVQMLLQMGA---SHTSqeikSNKTILHLAVQAANPTL--VQLLLglprgDLRA 250
Cdd:PHA03100 115 ------------SKKSNS------YSIVEYLLDNGAnvnIKNS----DGENLLHLYLESNKIDLkiLKLLI-----DKGV 167

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26024319  251 FVNMK-----------------AHGNTALHMAAALPpgppQEAIVRHLLAAGADPTLRNLENEQPVHL 301
Cdd:PHA03100 168 DINAKnrvnyllsygvpinikdVYGFTPLHYAVYNN----NPEFVKYLLDLGANPNLVNKYGDTPLHI 231
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 103-177 6.50e-05

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.47  E-value: 6.50e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 26024319  103 LLVAAAANQPLIvEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDLeaRDFEGLTPLHTAVLA 177
Cdd:PLN03192 530 LTVASTGNAALL-EELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHI--RDANGNTALWNAISA 601
PHA03095 PHA03095
ankyrin-like protein; Provisional
 114-284 8.81e-05

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.86  E-value: 8.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  114 IVEDLLSLGAEPNATDHQGRSVLHVAATYG--LPGVLSAVFKSGIQVDleARDFEGLTPLHTAVLALNAAmlpasVCPRm 191
Cdd:PHA03095 204 IVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISIN--ARNRYGQTPLHYAAVFNNPR-----ACRR- 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  192 qnsqardrltcvqmLLQMGASHTsqeiksnktilhlAVQAANPTlvqlllglprgdlrAFVNMKAHGNTALhMAAALPPG 271
Cdd:PHA03095 276 --------------LIALGADIN-------------AVSSDGNT--------------PLSLMVRNNNGRA-VRAALAKN 313

                        170
                 ....*....|...
gi 26024319  272 PPQEAIVRHLLAA 284
Cdd:PHA03095 314 PSAETVAATLNTA 326
Ank_4 pfam13637
Ankyrin repeats (many copies);
101-143 1.83e-04

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 38.79  E-value: 1.83e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 26024319   101 TPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYG 143
Cdd:pfam13637   3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNG 45
PHA03095 PHA03095
ankyrin-like protein; Provisional
 58-134 1.90e-04

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.09  E-value: 1.90e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   58 AQDEEGDTLLHLFAARGLRWAA----YAAAEVlqmyrQLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGR 133
Cdd:PHA03095 217 ATDMLGNTPLHSMATGSSCKRSlvlpLLIAGI-----SINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGN 291


                 .
gi 26024319  134 S 134
Cdd:PHA03095 292 T 292
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 107-175 2.28e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.96  E-value: 2.28e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26024319  107 AAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGiqVDLEARDFEGLTPLHTAV 175
Cdd:PTZ00322  90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFG--ADPTLLDKDGKTPLELAE 156
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 139-301 2.92e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 42.29  E-value: 2.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  139 AATYGLPGVLSAVFKSGIQVDLEARDfeGLTPLHTAVlalnaamlpasvcpRMQNSQArdrltcVQMLLQMGA--SHTSQ 216
Cdd:PHA02875   9 AILFGELDIARRLLDIGINPNFEIYD--GISPIKLAM--------------KFRDSEA------IKLLMKHGAipDVKYP 66

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  217 EIKSNktiLHLAVQAANPTLVQLLLglprgDLRAFVN--MKAHGNTALHMAAALPpgppQEAIVRHLLAAGADPTLRNLE 294
Cdd:PHA02875  67 DIESE---LHDAVEEGDVKAVEELL-----DLGKFADdvFYKDGMTPLHLATILK----KLDIMKLLIARGADPDIPNTD 134


                 ....*..
gi 26024319  295 NEQPVHL 301
Cdd:PHA02875 135 KFSPLHL 141
Ank_5 pfam13857
Ankyrin repeats (many copies);
123-174 5.33e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 37.33  E-value: 5.33e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 26024319   123 AEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGiqVDLEARDFEGLTPLHTA 174
Cdd:pfam13857   7 IDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG--VDLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 114-299 6.53e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.10  E-value: 6.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  114 IVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDLEarDFEGLTPLHTA----------VLALNAAML 183
Cdd:PHA02874 106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIE--DDNGCYPIHIAikhnffdiikLLLEKGAYA 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  184 PAS---VCPRMQNSQARDRLTCVQMLLQMGaSHTSQEIKSNKTILHLAVqAANPTLVQLLLglprgDLRAFVNMKAHGNT 260
Cdd:PHA02874 184 NVKdnnGESPLHNAAEYGDYACIKLLIDHG-NHIMNKCKNGFTPLHNAI-IHNRSAIELLI-----NNASINDQDIDGST 256

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 26024319  261 ALHMaaALPPgPPQEAIVRHLLAAGADPTLRNLENEQPV 299
Cdd:PHA02874 257 PLHH--AINP-PCDIDIIDILLYHKADISIKDNKGENPI 292
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 93-277 8.37e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 40.74  E-value: 8.37e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   93 DIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDLEarDFEGLTPLH 172
Cdd:PHA02875  96 DVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIE--DCCGCTPLI 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  173 TAVLALNAAmlpasVCprmqnsqardrltcvQMLLQMGASHTSQEIKSNKTILHLAVQAANPTLVQLLLGlpRG-DLRAF 251
Cdd:PHA02875 174 IAMAKGDIA-----IC---------------KMLLDSGANIDYFGKNGCVAALCYAIENNKIDIVRLFIK--RGaDCNIM 231

                        170       180
                 ....*....|....*....|....*.
gi 26024319  252 VNMKAHGNTALHMAAALPPGPPQEAI 277
Cdd:PHA02875 232 FMIEGEECTILDMICNMCTNLESEAI 257
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 92-159 1.06e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 40.42  E-value: 1.06e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26024319   92 LDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVD 159
Cdd:PHA03100 185 INIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
Ank_2 pfam12796
Ankyrin repeats (3 copies);
93-160 1.24e-03

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 37.40  E-value: 1.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26024319    93 DIREHKGKTPLLVAAAANQPLIVEDLLSlGAEPNATDHqGRSVLHVAATYGLPGVLSAVFKSGIQVDL 160
Cdd:pfam12796  24 NLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVKLLLEKGADINV 89
PHA03095 PHA03095
ankyrin-like protein; Provisional
 56-185 1.32e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 40.39  E-value: 1.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   56 LLAQDEEGDTLLHLFA------ARGLRwaayaaaEVLQMYRQLDIREHKGKTPLLVAAAAN--QPLIVEDLLSLGAEPNA 127
Cdd:PHA03095 180 VYAVDDRFRSLLHHHLqsfkprARIVR-------ELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGISINA 252

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 26024319  128 TDHQGRSVLHVAATYGLPGVLSAVFKSGiqVDLEARDFEGLTPLHTAVLALNAAMLPA 185
Cdd:PHA03095 253 RNRYGQTPLHYAAVFNNPRACRRLIALG--ADINAVSSDGNTPLSLMVRNNNGRAVRA 308
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 63-241 1.47e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 40.38  E-value: 1.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  63 GDTLLHLFAARGLRWAAYAAAEV------LQMYRQLdireHKGKTPLLVAAAANQPLIVEDLLSLGAE---PNATD---- 129
Cdd:cd22192  51 GETALHVAALYDNLEAAVVLMEAapelvnEPMTSDL----YQGETALHIAVVNQNLNLVRELIARGADvvsPRATGtffr 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319 130 -------HQGRSVLHVAATYGLPGVLSAVFKSGiqVDLEARDFEGLTPLHTAVLALNAamlpASVCpRMQN----SQARD 198
Cdd:cd22192 127 pgpknliYYGEHPLSFAACVGNEEIVRLLIEHG--ADIRAQDSLGNTVLHILVLQPNK----TFAC-QMYDlilsYDKED 199

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 26024319 199 RLTCVQMLL-QMGAshtsqeiksnkTILHLAVQAANPTLVQLLL 241
Cdd:cd22192 200 DLQPLDLVPnNQGL-----------TPFKLAAKEGNIVMFQHLV 232
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 82-288 1.58e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 39.97  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   82 AAEVLQMYRQLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQVDlE 161
Cdd:PHA02875  18 ARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFAD-D 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  162 ARDFEGLTPLHTAVLALNAAMLpasvcprmqnsqardrltcvQMLLQMGAShTSQEIKSNKTILHLAVQAANPTLVQLLL 241
Cdd:PHA02875  97 VFYKDGMTPLHLATILKKLDIM--------------------KLLIARGAD-PDIPNTDKFSPLHLAVMMGDIKGIELLI 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 26024319  242 glprgDLRAFVNMK-AHGNTALHMAAALppgpPQEAIVRHLLAAGADP 288
Cdd:PHA02875 156 -----DHKACLDIEdCCGCTPLIIAMAK----GDIAICKMLLDSGANI 194
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 257-292 1.74e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 35.34  E-value: 1.74e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 26024319   257 HGNTALHMAAALppgPPQEAIVRHLLAAGADPTLRN 292
Cdd:pfam00023   1 DGNTPLHLAAGR---RGNLEIVKLLLSKGADVNARD 33
PHA02743 PHA02743
Viral ankyrin protein; Provisional
 203-265 2.15e-03

Viral ankyrin protein; Provisional


Pssm-ID: 222925 [Multi-domain]  Cd Length: 166  Bit Score: 38.26  E-value: 2.15e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26024319  203 VQMLLQMGASHTSQEIKSNKTILHLAVQAANPTLVQLLLGLPRGDLRAfVNMKAHgnTALHMA 265
Cdd:PHA02743  76 IELLVNMGADINARELGTGNTLLHIAASTKNYELAEWLCRQLGVNLGA-INYQHE--TAYHIA 135
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
 99-174 3.80e-03

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 38.97  E-value: 3.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  99 GKTPLLVAAAANQPLIVEDLLSLGAEPNAT-DHQGRSVLHVAATYG---------LPGVLSAVFKSGIQVDLEA-RDFEG 167
Cdd:cd22194 188 GETPLALAACTNQPEIVQLLMEKESTDITSqDSRGNTVLHALVTVAedsktqndfVKRMYDMILLKSENKNLETiRNNEG 267


                ....*..
gi 26024319 168 LTPLHTA 174
Cdd:cd22194 268 LTPLQLA 274
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 85-174 4.89e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 38.51  E-value: 4.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   85 VLQMYRQLDIREHKGKTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVaATYGLPGVLS--AVFKSGIQVDLEA 162
Cdd:PHA02876 361 LLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHF-ALCGTNPYMSvkTLIDRGANVNSKN 439

                         90
                 ....*....|..
gi 26024319  163 RDFEglTPLHTA 174
Cdd:PHA02876 440 KDLS--TPLHYA 449
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 30-171 5.21e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 38.73  E-value: 5.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319   30 SPQLPSPTGPSLETARAHILALGPQQLLAQdeeGDTLlhlfaarGLRWAAYAAAEVlqmyrqlDIREHKGKTPLLVAAAA 109
Cdd:PTZ00322  63 TPDHNLTTEEVIDPVVAHMLTVELCQLAAS---GDAV-------GARILLTGGADP-------NCRDYDGRTPLHIACAN 125

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 26024319  110 NQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVFKSGIQV-DLEAR----DFEGLTPL 171
Cdd:PTZ00322 126 GHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHfELGANakpdSFTGKPPS 192
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 98-130 6.76e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.80  E-value: 6.76e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 26024319    98 KGKTPLLVAAA-ANQPLIVEDLLSLGAEPNATDH 130
Cdd:pfam00023   1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 100-300 8.33e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 37.74  E-value: 8.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  100 KTPLLVAAAANQPLIVEDLLSLGAEPNATDHQGRSVLHVAATYGLPGVLSAVF--KSGI-QVDLEARDFEGLTPLHTAVL 176
Cdd:PHA02876 179 ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIdnRSNInKNDLSLLKAIRNEDLETSLL 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26024319  177 ALNAAMLPASV-----CPRMQNSQARDRLTCVQMLLQMGASHTSQEIKSNKTILHLAVQAANPTLVQLLLGLPrGDLRAF 251
Cdd:PHA02876 259 LYDAGFSVNSIddcknTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTENIRTLIMLG-ADVNAA 337

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 26024319  252 VNMKahgNTALHMAAALppgPPQEAIVRHLLAAGADPTLRNLENEQPVH 300
Cdd:PHA02876 338 DRLY---ITPLHQASTL---DRNKDIVITLLELGANVNARDYCDKTPIH 380
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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