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Conserved domains on  [gi|27502427|ref|NP_758871|]
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membrane cofactor protein isoform 12 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
54-285 1.49e-41

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 145.95  E-value: 1.49e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427   54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLpvsDDACYRETCPYIRDPLNGQAvpANGTYEFGYQMHFICNEGYYL 133
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGTGWTL---FNQCIKRRCPSPRDIDNGQL--DIGGVDFGSSITYSCNSGYQL 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427  134 IGEEILYCEL--KGSVaIWSGKPPICEKVLCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESTIYCG 211
Cdd:PHA02927 119 IGESKSYCELgsTGSM-VWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLCS 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27502427  212 DNSvWSRAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Cdd:PHA02927 192 GGE-WSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
54-285 1.49e-41

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 145.95  E-value: 1.49e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427   54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLpvsDDACYRETCPYIRDPLNGQAvpANGTYEFGYQMHFICNEGYYL 133
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGTGWTL---FNQCIKRRCPSPRDIDNGQL--DIGGVDFGSSITYSCNSGYQL 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427  134 IGEEILYCEL--KGSVaIWSGKPPICEKVLCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESTIYCG 211
Cdd:PHA02927 119 IGESKSYCELgsTGSM-VWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLCS 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27502427  212 DNSvWSRAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Cdd:PHA02927 192 GGE-WSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
99-158 9.76e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 59.40  E-value: 9.76e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427  99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSvaiWSGKPPICE 158
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG---WSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
99-157 1.20e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.38  E-value: 1.20e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 27502427     99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSvaiWSGKPPIC 157
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT---WSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
231-283 1.64e-10

Sushi repeat (SCR repeat);


Pssm-ID: 425458 [Multi-domain]  Cd Length: 56  Bit Score: 55.98  E-value: 1.64e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 27502427   231 PVVENGKqISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Cdd:pfam00084   5 PDLPNGK-VSATKNEYNYGAQVEYECDPGYRLVGSPTITCQEDGTWSPPVPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
54-285 1.49e-41

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 145.95  E-value: 1.49e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427   54 YEIGERVDYKCKKGYFYIPPLATHTICDRNHTWLpvsDDACYRETCPYIRDPLNGQAvpANGTYEFGYQMHFICNEGYYL 133
Cdd:PHA02927  44 YNIGDTIEYLCLPGYRKQKMGPIYAKCTGTGWTL---FNQCIKRRCPSPRDIDNGQL--DIGGVDFGSSITYSCNSGYQL 118
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427  134 IGEEILYCEL--KGSVaIWSGKPPICEKVLCTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPApgpdpFSLIGESTIYCG 211
Cdd:PHA02927 119 IGESKSYCELgsTGSM-VWNPEAPICESVKCQSPPSISNGRHNGYE-DFYTDGSVVTYSCNSG-----YSLIGNSGVLCS 191
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 27502427  212 DNSvWSRAaPECKVVKCRFPVVENGKQISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Cdd:PHA02927 192 GGE-WSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPGNTWQPELPKCVR 263
PHA02639 PHA02639
EEV host range protein; Provisional
99-299 1.91e-33

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 125.55  E-value: 1.91e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427   99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSVAIWSGKPPICEKVLCTPPPKIKNGKhTFSEV 178
Cdd:PHA02639  22 CDKPDDISNGFITELMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAIWSNKAPFCMLKECNDPPSIINGK-IYNKR 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427  179 EVFEYLDAVTYSCDPAPGPDpFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENGkQISGF--GKKFYYKATVMFEC 256
Cdd:PHA02639 101 EMYKVGDEIYYVCNEHKGVQ-YSLVGNEKITCIQDKSWKPDPPICKMINCRFPALQNG-YINGIpsNKKFYYKTRVGFSC 178
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 27502427  257 DKGFYLDGSDTIVCDSNSTWDPPVPKCLKGYP-------KPEEGILDSLD 299
Cdd:PHA02639 179 KSGFDLVGEKYSTCNINATWFPSIPTCVRNKPiddiiylKPVDDNFDDLD 228
PHA02817 PHA02817
EEV Host range protein; Provisional
157-285 1.23e-25

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 102.71  E-value: 1.23e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427  157 CEKVLCTPPPKIKNGkHTFSEVEVFEYLDAVTYSCDPAPGPDPFSLIGESTIYCGDNSVWSRAAPECKVVKCRFPVVENG 236
Cdd:PHA02817  19 CDLNKCCYPPSIKNG-YIYNKKTEYNIGSNVTFFCGNNTRGVRYTLVGEKNIICEKDGKWNKEFPVCKIIRCRFPALQNG 97
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 27502427  237 kQISGF--GKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKCLK 285
Cdd:PHA02817  98 -FVNGIpdSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSSWIPKVPICSR 147
PHA02831 PHA02831
EEV host range protein; Provisional
114-285 1.88e-24

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 100.45  E-value: 1.88e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427  114 NGTYEFGYQMHFICNEGYYLIgeeILYCElKGSvaiWSGKPPICEKVLCTPPPKIKNGkHTFSEVEVFEYLDAVTYSCDp 193
Cdd:PHA02831  37 NKVYEENENLEYKCNNNFDKV---FVTCN-NGS---WSTKNMCIGKRNCKDPVTILNG-YIKNKKDQYSFGDSVTYACK- 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427  194 APGPDPFSLIGESTIYCGDNSvWSRAAPECKVVKCRFPVVENGKqISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSN 273
Cdd:PHA02831 108 VNKLEKYSIVGNETVKCINKQ-WVPKYPVCKLIRCKYPALQNGF-LNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDIN 185
                        170
                 ....*....|..
gi 27502427  274 STWDPPVPKCLK 285
Cdd:PHA02831 186 SIWYPGIPKCVK 197
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
99-158 9.76e-12

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 59.40  E-value: 9.76e-12
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427  99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSvaiWSGKPPICE 158
Cdd:cd00033   1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGG---WSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
228-283 1.31e-11

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 59.01  E-value: 1.31e-11
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27502427 228 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Cdd:cd00033   1 CPPPpVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTENGGWSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
99-157 1.20e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.38  E-value: 1.20e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 27502427     99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSvaiWSGKPPIC 157
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT---WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
228-283 1.45e-10

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 56.00  E-value: 1.45e-10
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 27502427    228 CRFP-VVENGKqISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Cdd:smart00032   1 CPPPpDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
231-283 1.64e-10

Sushi repeat (SCR repeat);


Pssm-ID: 425458 [Multi-domain]  Cd Length: 56  Bit Score: 55.98  E-value: 1.64e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 27502427   231 PVVENGKqISGFGKKFYYKATVMFECDKGFYLDGSDTIVCDSNSTWDPPVPKC 283
Cdd:pfam00084   5 PDLPNGK-VSATKNEYNYGAQVEYECDPGYRLVGSPTITCQEDGTWSPPVPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
162-224 4.07e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.78  E-value: 4.07e-10
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 27502427 162 CTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPapgpdPFSLIGESTIYCGDNSVWSRAAPECK 224
Cdd:cd00033   1 CPPPPVPENGTVTGSK-GSYSYGSTVTYSCNE-----GYTLVGSSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
162-223 1.38e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 53.30  E-value: 1.38e-09
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27502427    162 CTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPapgpdPFSLIGESTIYCGDNSVWSRAAPEC 223
Cdd:smart00032   1 CPPPPDIENGTVTSSS-GTYSYGDTVTYSCDP-----GYTLIGSSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
162-223 4.86e-08

Sushi repeat (SCR repeat);


Pssm-ID: 425458 [Multi-domain]  Cd Length: 56  Bit Score: 49.04  E-value: 4.86e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27502427   162 CTPPPKIKNGKHTFSEvEVFEYLDAVTYSCDPapgpdPFSLIGESTIYCGDNSVWSRAAPEC 223
Cdd:pfam00084   1 CPPPPDLPNGKVSATK-NEYNYGAQVEYECDP-----GYRLVGSPTITCQEDGTWSPPVPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
99-157 2.29e-07

Sushi repeat (SCR repeat);


Pssm-ID: 425458 [Multi-domain]  Cd Length: 56  Bit Score: 47.12  E-value: 2.29e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 27502427    99 CPYIRDPLNGQAVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSvaiWSGKPPIC 157
Cdd:pfam00084   1 CPPPPDLPNGKVSATKNEYNYGAQVEYECDPGYRLVGSPTITCQEDGT---WSPPVPEC 56
PHA02817 PHA02817
EEV Host range protein; Provisional
29-159 3.76e-04

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 41.46  E-value: 3.76e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27502427   29 YSFSD--ACEEPPTFEAMELIGKpKPYYEIGERVDYKC---KKGYFYIPPLATHTICDRNHTWLPvSDDACYRETC--PY 101
Cdd:PHA02817  16 YSLCDlnKCCYPPSIKNGYIYNK-KTEYNIGSNVTFFCgnnTRGVRYTLVGEKNIICEKDGKWNK-EFPVCKIIRCrfPA 93
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 27502427  102 IRDP-LNGqaVPANGTYEFGYQMHFICNEGYYLIGEEILYCELKGSvaiWSGKPPICEK 159
Cdd:PHA02817  94 LQNGfVNG--IPDSKKFYYESEVSFSCKPGFVLIGTKYSVCGINSS---WIPKVPICSR 147
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
35-88 1.06e-03

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 36.74  E-value: 1.06e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 27502427     35 CEEPPTFEAMELIGkPKPYYEIGERVDYKCKKGYFYIPPlaTHTICDRNHTWLP 88
Cdd:smart00032   1 CPPPPDIENGTVTS-SSGTYSYGDTVTYSCDPGYTLIGS--STITCLENGTWSP 51
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
35-88 1.99e-03

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 35.90  E-value: 1.99e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 27502427  35 CEEPPTFEAMELIGkPKPYYEIGERVDYKCKKGYFYIPPlaTHTICDRNHTWLP 88
Cdd:cd00033   1 CPPPPVPENGTVTG-SKGSYSYGSTVTYSCNEGYTLVGS--STITCTENGGWSP 51
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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