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Conserved domains on  [gi|119226195|ref|NP_765980|]
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zinc finger protein 759 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204268)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

CATH:  3.30.160.60
Gene Ontology:  GO:0003700|GO:0046872
PubMed:  22803940

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-63 1.93e-22

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 91.11  E-value: 1.93e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 119226195     5 LSFWDVVIYFSAEEREYLGPPQWKLYRDVMLENYNNLVFLGLASSKPYLVRFLEQIQEP 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-521 1.78e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 132 KPYKYETCSKAFHVPSKLSQHKIIRTGEKPYNCEV--CAKAFKYPSRLSKHKIIHKGEKPYKCKVCGKAFFSPSSICQHE 209
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 210 RIHTGE-LPCKCDVCGKAFQYPSLLSKHKIIHTEQKPYKCEVCGNFLRSR----SSLHEHKRMHAGEKPYKCevcgkafe 284
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnSLHPPLPANSLSKDPSSN-------- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 285 ypSRLSKHKNIHTGETPYKCKVCGKAFRSPSSLRVHKGIHREDKPYKCEVCGKAFRYSSVLSDHKNIHTGETPYKCKVCG 364
Cdd:COG5048  184 --LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 365 KAFRSPSSLRVHKGTH-------RGGKPYKCEVCGKAFHYPSILSNHKN--IHTGE--TPYKCKV--CGKAFHSPSSLIL 431
Cdd:COG5048  262 RSSLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 432 HKGTHREDKPYKC--EVCGKAFRYPSILSNHKKIHREQKPSKCKV-------GRKVFWSPSSLPEQKRIHTREKPYNCE- 501
Cdd:COG5048  342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                        410       420
                 ....*....|....*....|.
gi 119226195 502 -ICGKAFKYPSRLLKHKIIHT 521
Cdd:COG5048  422 pPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
384-716 3.26e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 3.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 384 KPYKCEVCGKAFHYPSILSNHKNIHTGETPYKCKV--CGKAFHSPSSLILHKGTHREDkpykcevcgkafryPSILSNHK 461
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNN--------------PSDLNSKS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 462 KIHREQKPSKCKVGRKVFWSPsslpeqkrihtreKPYNCEICGKAFKYPSRLLKHKIIHTREKQYKCKVCGNAFC-TPSS 540
Cdd:COG5048   98 LPLSNSKASSSSLSSSSSNSN-------------DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 541 LWQHKRIHTGELpckcdvCGKTFRFPSLLLKHKISHTDQKPYKCKICGNFLRSQSSLHEHKRMHAgEKPYKCEICGKAFE 620
Cdd:COG5048  165 NSLHPPLPANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 621 YPSRLSKHNNIHTGETPYKCKVCGKAFRSPSSLRVHKGIHRE-------DKPFKCEVCGKAFRYSSVLSDHKN--IHTGE 691
Cdd:COG5048  238 KSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                        330       340
                 ....*....|....*....|....*....
gi 119226195 692 --TPYKCKV--CGKAFRTTSSLHIHKGIH 716
Cdd:COG5048  318 slKPFSCPYslCGKLFSRNDALKRHILLH 346
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-63 1.93e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 91.11  E-value: 1.93e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 119226195     5 LSFWDVVIYFSAEEREYLGPPQWKLYRDVMLENYNNLVFLGLASSKPYLVRFLEQIQEP 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-45 7.59e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 74.43  E-value: 7.59e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 119226195    4 MLSFWDVVIYFSAEEREYLGPPQWKLYRDVMLENYNNLVFLG 45
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-44 3.97e-11

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 58.33  E-value: 3.97e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 119226195   5 LSFWDVVIYFSAEEREYLGPPQWKLYRDVMLENYNNLVFL 44
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-521 1.78e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 132 KPYKYETCSKAFHVPSKLSQHKIIRTGEKPYNCEV--CAKAFKYPSRLSKHKIIHKGEKPYKCKVCGKAFFSPSSICQHE 209
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 210 RIHTGE-LPCKCDVCGKAFQYPSLLSKHKIIHTEQKPYKCEVCGNFLRSR----SSLHEHKRMHAGEKPYKCevcgkafe 284
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnSLHPPLPANSLSKDPSSN-------- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 285 ypSRLSKHKNIHTGETPYKCKVCGKAFRSPSSLRVHKGIHREDKPYKCEVCGKAFRYSSVLSDHKNIHTGETPYKCKVCG 364
Cdd:COG5048  184 --LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 365 KAFRSPSSLRVHKGTH-------RGGKPYKCEVCGKAFHYPSILSNHKN--IHTGE--TPYKCKV--CGKAFHSPSSLIL 431
Cdd:COG5048  262 RSSLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 432 HKGTHREDKPYKC--EVCGKAFRYPSILSNHKKIHREQKPSKCKV-------GRKVFWSPSSLPEQKRIHTREKPYNCE- 501
Cdd:COG5048  342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                        410       420
                 ....*....|....*....|.
gi 119226195 502 -ICGKAFKYPSRLLKHKIIHT 521
Cdd:COG5048  422 pPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
384-716 3.26e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 3.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 384 KPYKCEVCGKAFHYPSILSNHKNIHTGETPYKCKV--CGKAFHSPSSLILHKGTHREDkpykcevcgkafryPSILSNHK 461
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNN--------------PSDLNSKS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 462 KIHREQKPSKCKVGRKVFWSPsslpeqkrihtreKPYNCEICGKAFKYPSRLLKHKIIHTREKQYKCKVCGNAFC-TPSS 540
Cdd:COG5048   98 LPLSNSKASSSSLSSSSSNSN-------------DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 541 LWQHKRIHTGELpckcdvCGKTFRFPSLLLKHKISHTDQKPYKCKICGNFLRSQSSLHEHKRMHAgEKPYKCEICGKAFE 620
Cdd:COG5048  165 NSLHPPLPANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 621 YPSRLSKHNNIHTGETPYKCKVCGKAFRSPSSLRVHKGIHRE-------DKPFKCEVCGKAFRYSSVLSDHKN--IHTGE 691
Cdd:COG5048  238 KSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                        330       340
                 ....*....|....*....|....*....
gi 119226195 692 --TPYKCKV--CGKAFRTTSSLHIHKGIH 716
Cdd:COG5048  318 slKPFSCPYslCGKLFSRNDALKRHILLH 346
zf-H2C2_2 pfam13465
Zinc-finger double domain;
176-199 9.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.79e-03
                          10        20
                  ....*....|....*....|....
gi 119226195  176 RLSKHKIIHKGEKPYKCKVCGKAF 199
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
5-63 1.93e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 91.11  E-value: 1.93e-22
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 119226195     5 LSFWDVVIYFSAEEREYLGPPQWKLYRDVMLENYNNLVFLGLASSKPYLVRFLEQIQEP 63
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEP 59
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-45 7.59e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 74.43  E-value: 7.59e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 119226195    4 MLSFWDVVIYFSAEEREYLGPPQWKLYRDVMLENYNNLVFLG 45
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 5-44 3.97e-11

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 58.33  E-value: 3.97e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 119226195   5 LSFWDVVIYFSAEEREYLGPPQWKLYRDVMLENYNNLVFL 44
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-521 1.78e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.48  E-value: 1.78e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 132 KPYKYETCSKAFHVPSKLSQHKIIRTGEKPYNCEV--CAKAFKYPSRLSKHKIIHKGEKPYKCKVCGKAFFSPSSICQHE 209
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 210 RIHTGE-LPCKCDVCGKAFQYPSLLSKHKIIHTEQKPYKCEVCGNFLRSR----SSLHEHKRMHAGEKPYKCevcgkafe 284
Cdd:COG5048  112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnSLHPPLPANSLSKDPSSN-------- 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 285 ypSRLSKHKNIHTGETPYKCKVCGKAFRSPSSLRVHKGIHREDKPYKCEVCGKAFRYSSVLSDHKNIHTGETPYKCKVCG 364
Cdd:COG5048  184 --LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESP 261

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 365 KAFRSPSSLRVHKGTH-------RGGKPYKCEVCGKAFHYPSILSNHKN--IHTGE--TPYKCKV--CGKAFHSPSSLIL 431
Cdd:COG5048  262 RSSLPTASSQSSSPNEsdsssekGFSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKR 341

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 432 HKGTHREDKPYKC--EVCGKAFRYPSILSNHKKIHREQKPSKCKV-------GRKVFWSPSSLPEQKRIHTREKPYNCE- 501
Cdd:COG5048  342 HILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQYKDLKNDKKsetlsnsCIRNFKRDSNLSLHIITHLSFRPYNCKn 421

                        410       420
                 ....*....|....*....|.
gi 119226195 502 -ICGKAFKYPSRLLKHKIIHT 521
Cdd:COG5048  422 pPCSKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
272-713 9.39e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.17  E-value: 9.39e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 272 KPYKCEVCGKAFEYPSRLSKHKNIHTGETPYKCKV--CGKAFRSPSSLRVHKGIHREDKPYKCEVCGKAFRYSSVLSDHk 349
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL- 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 350 NIHTGETPYKCKVCGKAFRSPSSLRVHKgthrggKPYKCEVCGKAFHYPSILSNHKNIHTGETPYKCKV---CGKAFHSP 426
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLP------DLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAnslSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 427 SSLILHKGTHREDKPYKCEVCGKAFRYPSILSNHKKIHRE-----QKPSKCKVGRKVFWSPSSLPEQKRIHTREKPYNCE 501
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSsslplTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 502 ICGKAFKYPSRLLKHKIIHTR-EKQYKCKVCGNAFCTPSSLWQHKR--IHTGE--LPCKCDV--CGKTFRFPSLLLKHKI 574
Cdd:COG5048  265 LPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 575 SHTDQKPYKCKIC-GNFLRSQSSLHEHKRMHagekpykceicgkafeYPSRLSKHNNIHTGETPYKCKVCGKAFRSPSSL 653
Cdd:COG5048  345 LHTSISPAKEKLLnSSSKFSPLLNNEPPQSL----------------QQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHI 408

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 654 RVHKGihREDKPFKCEVCGKAFRYSSVLSDHKNIHTGETPYKCKVCGKAFRTTSSLHIHK 713
Cdd:COG5048  409 ITHLS--FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
384-716 3.26e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 3.26e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 384 KPYKCEVCGKAFHYPSILSNHKNIHTGETPYKCKV--CGKAFHSPSSLILHKGTHREDkpykcevcgkafryPSILSNHK 461
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNN--------------PSDLNSKS 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 462 KIHREQKPSKCKVGRKVFWSPsslpeqkrihtreKPYNCEICGKAFKYPSRLLKHKIIHTREKQYKCKVCGNAFC-TPSS 540
Cdd:COG5048   98 LPLSNSKASSSSLSSSSSNSN-------------DNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVnTPQS 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 541 LWQHKRIHTGELpckcdvCGKTFRFPSLLLKHKISHTDQKPYKCKICGNFLRSQSSLHEHKRMHAgEKPYKCEICGKAFE 620
Cdd:COG5048  165 NSLHPPLPANSL------SKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSP 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 621 YPSRLSKHNNIHTGETPYKCKVCGKAFRSPSSLRVHKGIHRE-------DKPFKCEVCGKAFRYSSVLSDHKN--IHTGE 691
Cdd:COG5048  238 KSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGE 317

                        330       340
                 ....*....|....*....|....*....
gi 119226195 692 --TPYKCKV--CGKAFRTTSSLHIHKGIH 716
Cdd:COG5048  318 slKPFSCPYslCGKLFSRNDALKRHILLH 346
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 368-462 4.93e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.72  E-value: 4.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 368 RSPSSLRVHKGthrgGKPYKCEV--CGKAFHYPSILSNHKnihtgetpyKCKVCGKAFHSPSSLILHKGTHREDKPYKCE 445
Cdd:COG5189  336 DTPSRMLKVKD----GKPYKCPVegCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCE 402

                         90
                 ....*....|....*..
gi 119226195 446 VCGKAFRYPSILSNHKK 462
Cdd:COG5189  403 VCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 270-349 5.52e-06

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 49.33  E-value: 5.52e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 270 GEKPYKCEV--CGKAFEYPS-----RLSKHKNIHTGETPykckvcgkafrSPSSlrvHKGIHREDKPYKCEVCGKAFRYS 342
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNglkyhMLHGHQNQKLHENP-----------SPEK---MNIFSAKDKPYRCEVCDKRYKNL 411


                 ....*..
gi 119226195 343 SVLSDHK 349
Cdd:COG5189  412 NGLKYHR 418
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
79-472 8.67e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 8.67e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195  79 NSSTCKEVSEREKVLGNQQIIHLGLKPYSCEEVG--KSFCFSSLLSEHKRIHTGEKPykYETCSKAFHVPSKLSQHKIIR 156
Cdd:COG5048   35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGcdKSFSRPLELSRHLRTHHNNPS--DLNSKSLPLSNSKASSSSLSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 157 TGE---KPYNCEVCAKAFKYPSRLSK--HKIIHKGEKPYKcKVCGKAFFSPSSICQHERIHTGELpckcdvCGKAFQYPS 231
Cdd:COG5048  113 SSSnsnDNNLLSSHSLPPSSRDPQLPdlLSISNLRNNPLP-GNNSSSVNTPQSNSLHPPLPANSL------SKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 232 LLSKHKIIHTEQKPYKCEVCGNFLRSRSSLHEHKRMHAgEKPYKCEVCGKAFEYPSRLSKHKNIHTGETPYKCKVCGKAF 311
Cdd:COG5048  186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 312 RSPSSLRVHKGIHRE-------DKPYKCEVCGKAFRYSSVLSDHKN--IHTGE--TPYKCKV--CGKAFRSPSSLRVHKG 378
Cdd:COG5048  265 LPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 379 THRGGKPYKC--EVCGKAFHYPSILSNH---------KNIHTGETPYKCKVcgKAFHSPSSLILHKGTHREDKP--YKCE 445
Cdd:COG5048  345 LHTSISPAKEklLNSSSKFSPLLNNEPPqslqqykdlKNDKKSETLSNSCI--RNFKRDSNLSLHIITHLSFRPynCKNP 422

                        410       420
                 ....*....|....*....|....*..
gi 119226195 446 VCGKAFRYPSILSNHKKIHREQKPSKC 472
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIHTNHAPLLC 449
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 606-685 3.42e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 3.42e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 606 GEKPYKCEI--CGKAFEYPS-----RLSKHNNIHTGETPykckvcgkafrSPSSlrvHKGIHREDKPFKCEVCGKAFRYS 678
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNglkyhMLHGHQNQKLHENP-----------SPEK---MNIFSAKDKPYRCEVCDKRYKNL 411


                 ....*..
gi 119226195 679 SVLSDHK 685
Cdd:COG5189  412 NGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 562-658 4.25e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 46.63  E-value: 4.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 562 TFRFPSLLLKHKishtDQKPYKCKI--CGNFLRSQSSLHEHkRMHAGEKPykceicgKAFEYPSRlSKHNNIHTGETPYK 639
Cdd:COG5189  334 NIDTPSRMLKVK----DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQ-------KLHENPSP-EKMNIFSAKDKPYR 400

                         90
                 ....*....|....*....
gi 119226195 640 CKVCGKAFRSPSSLRVHKG 658
Cdd:COG5189  401 CEVCDKRYKNLNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
327-716 1.15e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 1.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 327 DKPYKCEVCGKAFRYSSVLSDHKNIHTGETPYKCKV--CGKAFRSPSSLRVHKGTHRGGKPYKCevCGKAFHYPSILSNH 404
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLN--SKSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 405 KNIHTGETP---YKCKVCGKAFHSPSSLILHKGTHREDKPYKCEVCGKAFRyPSILSNHKKIhreQKPSKCKVGRKVFWS 481
Cdd:COG5048  109 SLSSSSSNSndnNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSV-NTPQSNSLHP---PLPANSLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 482 PSSLPEQKrIHTREKPYNCEICGKAFKYPSRLLKHKIIHTREKqYKCKVCGNAFCTPSSLWQHKRIHTGELPCKCDVCGK 561
Cdd:COG5048  185 SLLISSNV-STSIPSSSENSPLSSSYSIPSSSSDQNLENSSSS-LPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 562 TFRFPSLLLKHKISHTD-------QKPYKCKICGNFLRSQSSLHEHKRM--HAGE--KPYKC--EICGKAFEYPSRLSKH 628
Cdd:COG5048  263 SSLPTASSQSSSPNESDsssekgfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 629 NNIHTGETPYKCK--VCGKAFRSPS-----SLRVHKGIHREDKPFKCEV--CGKAFRYSSVLSDHKNIHTGETP--YKCK 697
Cdd:COG5048  343 ILLHTSISPAKEKllNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNP 422

                        410
                 ....*....|....*....
gi 119226195 698 VCGKAFRTTSSLHIHKGIH 716
Cdd:COG5048  423 PCSKSFNRHYNLIPHKKIH 441
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 284-378 2.84e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.94  E-value: 2.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 284 EYPSRLSKHKnihtGETPYKCKV--CGKAFRSPSSLRVHKgIHREDKPYKCEVCGKafryssvlSDHKNIHTGETPYKCK 361
Cdd:COG5189  336 DTPSRMLKVK----DGKPYKCPVegCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCE 402

                         90
                 ....*....|....*..
gi 119226195 362 VCGKAFRSPSSLRVHKG 378
Cdd:COG5189  403 VCDKRYKNLNGLKYHRK 419
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 172-265 4.58e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 172 KYPSRLSKHKiihkGEKPYKCKV--CGKAFFSPSSICQHeRIHTGELPckcdvcgKAFQYPSLlSKHKIIHTEQKPYKCE 249
Cdd:COG5189  336 DTPSRMLKVK----DGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQ-------KLHENPSP-EKMNIFSAKDKPYRCE 402

                         90
                 ....*....|....*.
gi 119226195 250 VCGNFLRSRSSLHEHK 265
Cdd:COG5189  403 VCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 438-517 4.58e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 4.58e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 438 EDKPYKCEV--CGKAFRYPSILSNHKKiHREQKPskckvgrKVFWSPSSLPEQKrIHTREKPYNCEICGKAFKYPSRLLK 515
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHML-HGHQNQ-------KLHENPSPEKMNI-FSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 119226195 516 HK 517
Cdd:COG5189  417 HR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 620-714 1.23e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 1.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 119226195 620 EYPSRlskhNNIHTGETPYKCKV--CGKAFRSPSSLRVHKgIHREDKPFKCEVCGKafryssvlSDHKNIHTGETPYKCK 697
Cdd:COG5189  336 DTPSR----MLKVKDGKPYKCPVegCNKKYKNQNGLKYHM-LHGHQNQKLHENPSP--------EKMNIFSAKDKPYRCE 402

                         90
                 ....*....|....*..
gi 119226195 698 VCGKAFRTTSSLHIHKG 714
Cdd:COG5189  403 VCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
176-199 9.79e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.79e-03
                          10        20
                  ....*....|....*....|....
gi 119226195  176 RLSKHKIIHKGEKPYKCKVCGKAF 199
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-285 9.89e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.89e-03
                          10        20
                  ....*....|....*....|...
gi 119226195  263 EHKRMHAGEKPYKCEVCGKAFEY 285
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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