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Conserved domains on  [gi|27369654|ref|NP_766071|]
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zinc finger protein 180 isoform e [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|11179890|12665246|10940247

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-410 1.88e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 148 CGKSFSWSSHLIaHQRTHTGEKPYKCNLCGKFFTRSSHVVSHQRIHTGEKPYRCNLCGKSFTQRYVLVVHQRTHTgerPY 227
Cdd:COG5048 177 SKDPSSNLSLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS---SD 252

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 228 ECTQCGKSFRQSYKLIAHQRTH----------TGEKPYECTQCGKSFIQSYKLIAHQ--KIHSGE--KPYECSH--CGKS 291
Cdd:COG5048 253 SSSSASESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKL 332

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 292 FSQSYKLVAHQRTHTGEKPFEC--NHCGKSFS-----WSSQLVSHQRTHTGEKPYEC--NECGKSFNRSSHLVMHQRTHT 362
Cdd:COG5048 333 FSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHL 412

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 27369654 363 GEKPYQCK--QCGKSFSQSYVLVVHQRTHTGEKPYECGQCGKTFRQSSCF 410
Cdd:COG5048 413 SFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLS 462
zf-H2C2_2 pfam13465
Zinc-finger double domain;
412-433 1.85e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|..
gi 27369654   412 QHQRTHTGEKPYECNQCGKTFS 433
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-462 2.21e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 27369654   437 RLIVHQRTHTGEKPYKCGQCGKAFIS 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-410 1.88e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 148 CGKSFSWSSHLIaHQRTHTGEKPYKCNLCGKFFTRSSHVVSHQRIHTGEKPYRCNLCGKSFTQRYVLVVHQRTHTgerPY 227
Cdd:COG5048 177 SKDPSSNLSLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS---SD 252

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 228 ECTQCGKSFRQSYKLIAHQRTH----------TGEKPYECTQCGKSFIQSYKLIAHQ--KIHSGE--KPYECSH--CGKS 291
Cdd:COG5048 253 SSSSASESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKL 332

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 292 FSQSYKLVAHQRTHTGEKPFEC--NHCGKSFS-----WSSQLVSHQRTHTGEKPYEC--NECGKSFNRSSHLVMHQRTHT 362
Cdd:COG5048 333 FSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHL 412

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 27369654 363 GEKPYQCK--QCGKSFSQSYVLVVHQRTHTGEKPYECGQCGKTFRQSSCF 410
Cdd:COG5048 413 SFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLS 462
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 145-193 8.03e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.00  E-value: 8.03e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 27369654 145 CKYCGKSFSWSSHLIAHQRTHTgekpYKCNLCGKFFTRSSHVVSH-QRIH 193
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
353-378 1.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 27369654   353 HLVMHQRTHTGEKPYQCKQCGKSFSQ 378
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
412-433 1.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|..
gi 27369654   412 QHQRTHTGEKPYECNQCGKTFS 433
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-462 2.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 27369654   437 RLIVHQRTHTGEKPYKCGQCGKAFIS 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
148-410 1.88e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 1.88e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 148 CGKSFSWSSHLIaHQRTHTGEKPYKCNLCGKFFTRSSHVVSHQRIHTGEKPYRCNLCGKSFTQRYVLVVHQRTHTgerPY 227
Cdd:COG5048 177 SKDPSSNLSLLI-SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS---SD 252

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 228 ECTQCGKSFRQSYKLIAHQRTH----------TGEKPYECTQCGKSFIQSYKLIAHQ--KIHSGE--KPYECSH--CGKS 291
Cdd:COG5048 253 SSSSASESPRSSLPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKL 332

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 292 FSQSYKLVAHQRTHTGEKPFEC--NHCGKSFS-----WSSQLVSHQRTHTGEKPYEC--NECGKSFNRSSHLVMHQRTHT 362
Cdd:COG5048 333 FSRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHL 412

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 27369654 363 GEKPYQCK--QCGKSFSQSYVLVVHQRTHTGEKPYECGQCGKTFRQSSCF 410
Cdd:COG5048 413 SFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLS 462
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
122-475 1.33e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.93  E-value: 1.33e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 122 CKTAPSPSLPQSLRNYSEEKR-FECKYCGKSFSWSSHLIAHQRTHTGEKPYKCNLCGKF--FTRSSHVVSHQRIHTGEKP 198
Cdd:COG5048  12 NNSVLSSTPKSTLKSLSNAPRpDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDksFSRPLELSRHLRTHHNNPS 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 199 YR-----------------------------CNLCGKSFTQRYVLVVHQRTHTGERPYECTQCGKSFRQSYK-------- 241
Cdd:COG5048  92 DLnskslplsnskasssslsssssnsndnnlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQsnslhppl 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 242 --------------LIAHQRTHTGEKPYECTQCGKSFIQSYKLIAHQKIHSGEKPYECSHCGKSFSQSYKLVAHQRT--- 304
Cdd:COG5048 172 panslskdpssnlsLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsss 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 305 ---HTGEKPFECNHCGKSFSWSSQLVSHQRTHTG-EKPYECNECGKSFNRSSHLVMHQRT--HTGE--KPYQC--KQCGK 374
Cdd:COG5048 252 dssSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGK 331

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 375 SFSQSYVLVVHQRTHTGEKPYEC--GQCGKTFRQSS-----CFTQHQRTHTGEKPYEC--NQCGKTFSLSARLIVHQRTH 445
Cdd:COG5048 332 LFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                       410       420       430
                ....*....|....*....|....*....|..
gi 27369654 446 TGEKP--YKCGQCGKAFISSSKRSRHQATHSE 475
Cdd:COG5048 412 LSFRPynCKNPPCSKSFNRHYNLIPHKKIHTN 443
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
216-471 8.04e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 8.04e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 216 VHQRTHTGERPYECTQCGKSFRQSYKLIAHQRTHTGEKPYECTQCGKSFIQSYKLIAHQKIHSgekPYECSHCGKSFSQS 295
Cdd:COG5048 188 ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSASESPRSS 264

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 296 YKLVAHQRTH----------TGEKPFECNHCGKSFSWSSQLVSHQRT--HTGE--KPYECNE--CGKSFNRSSHLVMHQR 359
Cdd:COG5048 265 LPTASSQSSSpnesdsssekGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 360 THTGEKPYQCK--QCGKSFSQ-----SYVLVVHQRTHTGEKPYEC--GQCGKTFRQSSCFTQHQRTHTGEKPYECN--QC 428
Cdd:COG5048 345 LHTSISPAKEKllNSSSKFSPllnnePPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPC 424

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 27369654 429 GKTFSLSARLIVHQRTHTGEKPYKCGQCGKAFISSSKRSRHQA 471
Cdd:COG5048 425 SKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
127-357 2.40e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.40e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 127 SPSLPQSLRNYSEEKRFECkyCGKSFSWSSHLIAHQRTHtgekpYKCNLCGKFFTRSSHVVSHQRIHTG-EKPYRCNLCG 205
Cdd:COG5048 224 SSSLPLTTNSQLSPKSLLS--QSPSSLSSSDSSSSASES-----PRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCN 296

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 206 KSFTQRYVLVVHQRT--HTGE--RPYECT--QCGKSFRQSYKLIAHQRTHTGEKPYEC--TQCGKSFIQ-----SYKLIA 272
Cdd:COG5048 297 ISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPllnnePPQSLQ 376

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 273 HQKIHSGEKPYECSH--CGKSFSQSYKLVAHQRTHTGEKP--FECNHCGKSFSWSSQLVSHQRTHTGEKPYECNECgKSF 348
Cdd:COG5048 377 QYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL-KSF 455


                ....*....
gi 27369654 349 NRSSHLVMH 357
Cdd:COG5048 456 RRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
123-321 3.55e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.31  E-value: 3.55e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 123 KTAPSPSLPQSLRNYSEEKRFECKYCGKSFSWSSHLIAHQRT--HTGE--KPYKC--NLCGKFFTRSSHVVSHQRIHTGE 196
Cdd:COG5048 270 SQSSSPNESDSSSEKGFSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSI 349

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369654 197 KPYRCNL--CGKSFTQ-----RYVLVVHQRTHTGERPYECT--QCGKSFRQSYKLIAHQRTHTGEKPYECTqcgksfiqs 267
Cdd:COG5048 350 SPAKEKLlnSSSKFSPllnnePPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCK--------- 420

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 27369654 268 ykliahqkihsgekpyeCSHCGKSFSQSYKLVAHQRTHTGEKPFECNHCGKSFS 321
Cdd:COG5048 421 -----------------NPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 145-193 8.03e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 41.00  E-value: 8.03e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 27369654 145 CKYCGKSFSWSSHLIAHQRTHTgekpYKCNLCGKFFTRSSHVVSH-QRIH 193
Cdd:cd20908   4 CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHcLQVH 49
zf-H2C2_2 pfam13465
Zinc-finger double domain;
353-378 1.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 27369654   353 HLVMHQRTHTGEKPYQCKQCGKSFSQ 378
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
326-350 2.38e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.38e-04
                          10        20
                  ....*....|....*....|....*
gi 27369654   326 LVSHQRTHTGEKPYECNECGKSFNR 350
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 309-357 9.58e-04

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.92  E-value: 9.58e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 27369654 309 KPFeCNHCGKSFSWSSQLVSHQRTHTgekpYECNECGKSFNRSSHLVMH 357
Cdd:cd20908   1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
zf-H2C2_2 pfam13465
Zinc-finger double domain;
185-210 9.86e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.86e-04
                          10        20
                  ....*....|....*....|....*.
gi 27369654   185 HVVSHQRIHTGEKPYRCNLCGKSFTQ 210
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
214-238 1.19e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.19e-03
                          10        20
                  ....*....|....*....|....*
gi 27369654   214 LVVHQRTHTGERPYECTQCGKSFRQ 238
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-266 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|..
gi 27369654   245 HQRTHTGEKPYECTQCGKSFIQ 266
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
157-182 1.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.69e-03
                          10        20
                  ....*....|....*....|....*.
gi 27369654   157 HLIAHQRTHTGEKPYKCNLCGKFFTR 182
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 339-361 1.84e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.84e-03
                          10        20
                  ....*....|....*....|...
gi 27369654   339 YECNECGKSFNRSSHLVMHQRTH 361
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
412-433 1.85e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|..
gi 27369654   412 QHQRTHTGEKPYECNQCGKTFS 433
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
437-462 2.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 27369654   437 RLIVHQRTHTGEKPYKCGQCGKAFIS 462
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
298-321 2.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.32e-03
                          10        20
                  ....*....|....*....|....
gi 27369654   298 LVAHQRTHTGEKPFECNHCGKSFS 321
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
382-406 2.63e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.63e-03
                          10        20
                  ....*....|....*....|....*
gi 27369654   382 LVVHQRTHTGEKPYECGQCGKTFRQ 406
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 283-305 3.66e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.66e-03
                          10        20
                  ....*....|....*....|...
gi 27369654   283 YECSHCGKSFSQSYKLVAHQRTH 305
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
273-294 5.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.14e-03
                          10        20
                  ....*....|....*....|..
gi 27369654   273 HQKIHSGEKPYECSHCGKSFSQ 294
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 227-249 5.37e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 5.37e-03
                          10        20
                  ....*....|....*....|...
gi 27369654   227 YECTQCGKSFRQSYKLIAHQRTH 249
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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