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Conserved domains on  [gi|27369692|ref|NP_766089|]
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NHL repeat-containing protein 3 precursor [Mus musculus]

Protein Classification

NHL repeat-containing protein( domain architecture ID 110303)

NHL (NCL-1, HT2A and LIN-41) repeat-containing protein may have a catalytic activity or interact with other proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 66-336 8.38e-45

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14958:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 300  Bit Score: 155.50  E-value: 8.38e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVD-SLNGLVYV-AQRGDNIPkVLVFSEDGYFLRAW-NYTVDTPHGMFVSgtpFEQSVWITDVGSgpygHTVKKYNSLG 142
Cdd:cd14958  35 VWDAnSFDANVYVfKGPIEEDT-ILVFDPDGGFLRSWgAGLFYMPHGLTID---PDGNIWVTDVGL----HQVFKFDPEG 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 143 DLVQ--VLGTPGKKGTGLNPlqFDNPAELYVDDTGEMYIVDGDGglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVT 220
Cdd:cd14958 107 KLLPllTLGERGEPGSDQTH--FCKPTDVAVAPDGDIFVADGYC--NSRIVKFSPDGKLLKSWGEPGSGPGQFNLPHSIA 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 221 LDAVGRVWVADRGNKRLQVFDKDtGEWLGAWDNCFTEEgPSAVRFTPDGKYLIV-----AQLNLSRLSVLLAPPSGSIGD 295
Cdd:cd14958 183 LDEDGRVYVADRENGRIQVFDAD-GKFLTEWTNPELGR-PYALAIDPDGLLYVVdgpprLNRSLPVRGFVIRIGKGLILG 260

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 27369692 296 CSVVSTIQLADQVLPHLLEVDRKtGAVYVAEIGAKQIQKYI 336
Cdd:cd14958 261 RFGPGGKAPGQFQNPHDIAVDSG-GDIYVGELGPNRVQKFV 300
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 66-336 8.38e-45

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 155.50  E-value: 8.38e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVD-SLNGLVYV-AQRGDNIPkVLVFSEDGYFLRAW-NYTVDTPHGMFVSgtpFEQSVWITDVGSgpygHTVKKYNSLG 142
Cdd:cd14958  35 VWDAnSFDANVYVfKGPIEEDT-ILVFDPDGGFLRSWgAGLFYMPHGLTID---PDGNIWVTDVGL----HQVFKFDPEG 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 143 DLVQ--VLGTPGKKGTGLNPlqFDNPAELYVDDTGEMYIVDGDGglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVT 220
Cdd:cd14958 107 KLLPllTLGERGEPGSDQTH--FCKPTDVAVAPDGDIFVADGYC--NSRIVKFSPDGKLLKSWGEPGSGPGQFNLPHSIA 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 221 LDAVGRVWVADRGNKRLQVFDKDtGEWLGAWDNCFTEEgPSAVRFTPDGKYLIV-----AQLNLSRLSVLLAPPSGSIGD 295
Cdd:cd14958 183 LDEDGRVYVADRENGRIQVFDAD-GKFLTEWTNPELGR-PYALAIDPDGLLYVVdgpprLNRSLPVRGFVIRIGKGLILG 260

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 27369692 296 CSVVSTIQLADQVLPHLLEVDRKtGAVYVAEIGAKQIQKYI 336
Cdd:cd14958 261 RFGPGGKAPGQFQNPHDIAVDSG-GDIYVGELGPNRVQKFV 300
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
66-337 1.19e-15

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 75.83  E-value: 1.19e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGDNipKVLVFS-EDGYFLRAWNYTVDTPHGMFVSGtpfEQSVWITDVGsgpyGHTVKKYNSLGDL 144
Cdd:COG4257  22 VAVDP-DGAVWFTDQGGG--RIGRLDpATGEFTEYPLGGGSGPHGIAVDP---DGNLWFTDNG----NNRIGRIDPKTGE 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 145 VQVLGTPGKKgtglnplqfDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDfmilwlRGE--NGTGPAKFNIPHSVTLD 222
Cdd:COG4257  92 ITTFALPGGG---------SNPHGIAFDPDGNLWFTDQG---GNRIGRLDPA------TGEvtEFPLPTGGAGPYGIAVD 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 223 AVGRVWVADRGNKRLQVFDKDTGEwLGAWDNCFTEEGPSAVRFTPDGKYLIVAQLNlSRLSVlLAPPSGSigdcsvVSTI 302
Cdd:COG4257 154 PDGNLWVTDFGANAIGRIDPDTGT-LTEYALPTPGAGPRGLAVDPDGNLWVADTGS-GRIGR-FDPKTGT------VTEY 224

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 27369692 303 QLAD-QVLPHLLEVDRKtGAVYVAEIGAKQIQKYIP 337
Cdd:COG4257 225 PLPGgGARPYGVAVDGD-GRVWFAESGANRIVRFDP 259
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 213-240 6.81e-05

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 39.31  E-value: 6.81e-05
                          10        20
                  ....*....|....*....|....*...
gi 27369692   213 FNIPHSVTLDAVGRVWVADRGNKRLQVF 240
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
 
Name Accession Description Interval E-value
NHL_PAL_like cd14958
Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the ...
 66-336 8.38e-45

Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL, EC 4.3.2.5); PAL catalyzes the N-dealkylation of peptidyl-alpha-hydroxyglycine, which results in an alpha-amidated peptide and glyoxylate. Amidation of the C-terminus is required for the activity of many peptide hormones and neuropeptides. The catalytic residues of PAL are located on several NHL-repeats. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271328 [Multi-domain]  Cd Length: 300  Bit Score: 155.50  E-value: 8.38e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVD-SLNGLVYV-AQRGDNIPkVLVFSEDGYFLRAW-NYTVDTPHGMFVSgtpFEQSVWITDVGSgpygHTVKKYNSLG 142
Cdd:cd14958  35 VWDAnSFDANVYVfKGPIEEDT-ILVFDPDGGFLRSWgAGLFYMPHGLTID---PDGNIWVTDVGL----HQVFKFDPEG 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 143 DLVQ--VLGTPGKKGTGLNPlqFDNPAELYVDDTGEMYIVDGDGglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVT 220
Cdd:cd14958 107 KLLPllTLGERGEPGSDQTH--FCKPTDVAVAPDGDIFVADGYC--NSRIVKFSPDGKLLKSWGEPGSGPGQFNLPHSIA 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 221 LDAVGRVWVADRGNKRLQVFDKDtGEWLGAWDNCFTEEgPSAVRFTPDGKYLIV-----AQLNLSRLSVLLAPPSGSIGD 295
Cdd:cd14958 183 LDEDGRVYVADRENGRIQVFDAD-GKFLTEWTNPELGR-PYALAIDPDGLLYVVdgpprLNRSLPVRGFVIRIGKGLILG 260

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 27369692 296 CSVVSTIQLADQVLPHLLEVDRKtGAVYVAEIGAKQIQKYI 336
Cdd:cd14958 261 RFGPGGKAPGQFQNPHDIAVDSG-GDIYVGELGPNRVQKFV 300
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 66-335 1.96e-32

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 122.04  E-value: 1.96e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGDNipKVLVFSEDGYFLRAW------NYTVDTPHGMFVSGTpfeQSVWITDVGSgpygHTVKKYN 139
Cdd:cd05819  13 IAVDS-SGNIYVADTGNN--RIQVFDPDGNFITSFgsfgsgDGQFNEPAGVAVDSD---GNLYVADTGN----HRIQKFD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 140 SLGDLVQVLGtpgkkGTGLNPLQFDNPAELYVDDTGEMYIVDGdggLNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSV 219
Cdd:cd05819  83 PDGNFLASFG-----GSGDGDGEFNGPRGIAVDSSGNIYVADT---GNHRIQKFDPDGEFLTTFGSGGSGPGQFNGPTGV 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 220 TLDAVGRVWVADRGNKRLQVFDKDtGEWLGAWDNCFTEEG----PSAVRFTPDGkYLIVAQLNLSRlsVLLAPPSGSIGD 295
Cdd:cd05819 155 AVDSDGNIYVADTGNHRIQVFDPD-GNFLTTFGSTGTGPGqfnyPTGIAVDSDG-NIYVADSGNNR--VQVFDPDGAGFG 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 27369692 296 CSVVSTIQLADQVLPHLLEVDRKtGAVYVAEIGAKQIQKY 335
Cdd:cd05819 231 GNGNFLGSDGQFNRPSGLAVDSD-GNLYVADTGNNRIQVF 269
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 66-335 5.83e-28

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 110.05  E-value: 5.83e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGDNipKVLVFSEDGYFLRAW------NYTVDTPHGMFVSGTpfeQSVWITDVgsgpYGHTVKKYN 139
Cdd:cd14957  23 IAVDS-AGNIYVADTGNN--RIQVFTSSGVYSYSIgsggtgSGQFNSPYGIAVDSN---GNIYVADT----DNNRIQVFN 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 140 SLGDLVQVLGTpgkkgTGLNPLQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSV 219
Cdd:cd14957  93 SSGVYQYSIGT-----GGSGDGQFNGPYGIAVDSNGNIYVADTG---NHRIQVFTSSGTFSYSIGSGGTGPGQFNGPQGI 164

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 220 TLDAVGRVWVADRGNKRLQVFDKDtgewlGAWDNCFTEEGPSAVRF-TP-------DGKYLIVAQLNlSRLSVLLAppSG 291
Cdd:cd14957 165 AVDSDGNIYVADTGNHRIQVFTSS-----GTFQYTFGSSGSGPGQFsDPygiavdsDGNIYVADTGN-HRIQVFTS--SG 236

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 27369692 292 ----SIGdcsvvSTIQLADQV-LPHLLEVDrKTGAVYVAEIGAKQIQKY 335
Cdd:cd14957 237 ayqySIG-----TSGSGNGQFnYPYGIAVD-NDGKIYVADSNNNRIQVF 279
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-335 4.48e-27

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 107.75  E-value: 4.48e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQrgDNIPKVLVFSEDGYFLRAWNYTVDTPHGMfvsGTPFEQSV------WITDVGsgpyGHTVKKYN 139
Cdd:cd14956  18 IAVDA-DDNVYVAD--ARNGRIQVFDKDGTFLRRFGTTGDGPGQF---GRPRGLAVdkdgwlYVADYW----GDRIQVFT 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 140 SLGDLVQVLGTPGKkGTGlnplQFDNPAELYVDDTGEMYIvdGDGGlNNRLVKLSQD--FMILWlrGENGTGPAKFNIPH 217
Cdd:cd14956  88 LTGELQTIGGSSGS-GPG----QFNAPRGVAVDADGNLYV--ADFG-NQRIQKFDPDgsFLRQW--GGTGIEPGSFNYPR 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 218 SVTLDAVGRVWVADRGNKRLQVFDKDtGEWLGAWDNCFTEEG----PSAVRFTPDGKyLIVAQLNLSRLSVLLAP----- 288
Cdd:cd14956 158 GVAVDPDGTLYVADTYNDRIQVFDND-GAFLRKWGGRGTGPGqfnyPYGIAIDPDGN-VFVADFGNNRIQKFTADgtflt 235

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 27369692 289 PSGSIGDcsvvSTIQLADqvlPHLLEVDRkTGAVYVAEIGAKQIQKY 335
Cdd:cd14956 236 SWGSPGT----GPGQFKN---PWGVVVDA-DGTVYVADSNNNRVQRF 274
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 105-346 8.77e-27

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 106.63  E-value: 8.77e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 105 DTPHGMFVSGtpfEQSVWITDVGsgpyGHTVKKYNSLGDLVQVLGTPGKkgtglNPLQFDNPAELYVDDTGEMYIVDGDg 184
Cdd:cd05819   8 NNPQGIAVDS---SGNIYVADTG----NNRIQVFDPDGNFITSFGSFGS-----GDGQFNEPAGVAVDSDGNLYVADTG- 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 185 glNNRLVKLSQD--FMILWlrGENGTGPAKFNIPHSVTLDAVGRVWVADRGNKRLQVFDKDtGEWLGAW------DNCFt 256
Cdd:cd05819  75 --NHRIQKFDPDgnFLASF--GGSGDGDGEFNGPRGIAVDSSGNIYVADTGNHRIQKFDPD-GEFLTTFgsggsgPGQF- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 257 eEGPSAVRFTPDGkYLIVAQLNLSRLSVLlaPPSG----SIGDcSVVSTIQLADqvlPHLLEVDRkTGAVYVAEIGAKQI 332
Cdd:cd05819 149 -NGPTGVAVDSDG-NIYVADTGNHRIQVF--DPDGnfltTFGS-TGTGPGQFNY---PTGIAVDS-DGNIYVADSGNNRV 219

                       250
                ....*....|....
gi 27369692 333 QKYIPWHSRTPAFG 346
Cdd:cd05819 220 QVFDPDGAGFGGNG 233
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
 157-335 1.32e-21

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 92.77  E-value: 1.32e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 157 GLNPLQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVTLDAVGRVWVADRGNKR 236
Cdd:cd05819   1 GTGPGELNNPQGIAVDSSGNIYVADTG---NNRIQVFDPDGNFITSFGSFGSGDGQFNEPAGVAVDSDGNLYVADTGNHR 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 237 LQVFDKDtGEWLGAW----DNCFTEEGPSAVRFTPDGKYLIVAQLNlSRLSVLlaPPSG----SIGdCSVVSTIQLADqv 308
Cdd:cd05819  78 IQKFDPD-GNFLASFggsgDGDGEFNGPRGIAVDSSGNIYVADTGN-HRIQKF--DPDGefltTFG-SGGSGPGQFNG-- 150

                       170       180
                ....*....|....*....|....*..
gi 27369692 309 lPHLLEVDRKtGAVYVAEIGAKQIQKY 335
Cdd:cd05819 151 -PTGVAVDSD-GNIYVADTGNHRIQVF 175
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 66-260 5.03e-20

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 88.40  E-value: 5.03e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGDNipKVLVFSEDGYFLRAW------NYTVDTPHGMFV--SGtpfeqSVWITDvgsgPYGHTVKK 137
Cdd:cd14955  68 IAVDS-DGNVYVADTGNH--RIQKFDSTGTFLTKWgssgsgDGQFNSPSGIAVdsAG-----NVYVTD----SGNNRIQK 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 138 YNSLGdlvQVLGTPGKKGTGLNplQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIPH 217
Cdd:cd14955 136 FDSSG---TFITKWGSFGSGDG--QFNSPTGIAVDSAGNVYVADTG---NNRIQKFTSTGTFLTKWGSEGSGDGQFNAPY 207

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 27369692 218 SVTLDAVGRVWVADRGNKRLQVFDKdTGEWLGAWDNCFTEEGP 260
Cdd:cd14955 208 GIAVDSAGNVYVADTGNNRIQKFDS-SGTFITKWGSEGSGDGQ 249
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 66-241 5.84e-19

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 85.32  E-value: 5.84e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGDN-IPKvlvFSEDGYFLRAW------NYTVDTPHGMFVSGTpfeQSVWITDVGSgpygHTVKKY 138
Cdd:cd14955 115 IAVDS-AGNVYVTDSGNNrIQK---FDSSGTFITKWgsfgsgDGQFNSPTGIAVDSA---GNVYVADTGN----NRIQKF 183

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 139 NSLGDLVQVLGTPGKkGTGlnplQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQD--FMILWlrGENGTGPAKFNIP 216
Cdd:cd14955 184 TSTGTFLTKWGSEGS-GDG----QFNAPYGIAVDSAGNVYVADTG---NNRIQKFDSSgtFITKW--GSEGSGDGQFNSP 253

                       170       180
                ....*....|....*....|....*
gi 27369692 217 HSVTLDAVGRVWVADRGNKRLQVFD 241
Cdd:cd14955 254 SGIAVDSAGNVYVADSGNNRIQKFA 278
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 66-274 5.85e-18

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 82.60  E-value: 5.85e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGDNipKVLVFSEDGYFLRA--------------WNYTVDTPHGMFVSGTPfEQSVWITDvgsgPY 131
Cdd:cd14954  76 VAVNS-RGRIIVADKDNH--RIQVFDLNGRFLLKfgergtkngqfnypWGVAVDSEGRIYVSDTR-NHRVQVFD----SD 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 132 GHTVKKYNSLGDLvqvlgtpgkkgtglnPLQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPA 211
Cdd:cd14954 148 GQFIRKFGFEGAG---------------PGQLDSPRGVAVNPDGNIVVSDFN---NHRLQVFDPDGQFLRFFGSEGSGNG 209

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27369692 212 KFNIPHSVTLDAVGRVWVADRGNKRLQVFDKDtGEWL---GAWDNCFTE-EGPSAVRFTPDGKYLIV 274
Cdd:cd14954 210 QFKRPRGVAVDDEGNIIVADSGNHRVQVFSPD-GEFLcsfGTEGNGEGQfDRPSGVAVTPDGRIVVV 275
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 52-248 2.04e-17

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 80.71  E-value: 2.04e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  52 WPKNSEYFTGATFCVAVDSlNGLVYV--AQRGdnipKVLVFSEDGYFLRAWNYTVDT--PHGMFVSgtPFEQSVWITDVg 127
Cdd:cd14962  48 IGNAGPNRFVSPIGVAIDA-NGNLYVsdAELG----KVFVFDRDGKFLRAIGAGALFkrPTGIAVD--PAGKRLYVVDT- 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 128 sgpYGHTVKKYNSLGDLVQVLGTPGKKgtglnPLQFDNPAELYVDDTGEMYIVDGdggLNNRLVKLSQDFMILWLRGENG 207
Cdd:cd14962 120 ---LAHKVKVFDLDGRLLFDIGKRGSG-----PGEFNLPTDLAVDRDGNLYVTDT---MNFRVQIFDADGKFLRSFGERG 188

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 27369692 208 TGPAKFNIPHSVTLDAVGRVWVADRGNKRLQVFDKdTGEWL 248
Cdd:cd14962 189 DGPGSFARPKGIAVDSEGNIYVVDAAFDNVQIFNP-EGELL 228
NHL_like_4 cd14955
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 152-335 7.64e-17

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271325 [Multi-domain]  Cd Length: 279  Bit Score: 79.54  E-value: 7.64e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 152 GKKGTGLNplQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQD--FMILWlrGENGTGPAKFNIPHSVTLDAVGRVWV 229
Cdd:cd14955   6 GSYGSGDG--QFNSPSGIAVDSAGNVYVADTG---NNRIQKFDSTgtFLTKW--GSSGSGDGQFYSPTGIAVDSDGNVYV 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 230 ADRGNKRLQVFDKdTGEWLGAWDNCFTEEG----PSAVRFTPDGkYLIVAQLNLSRL-------SVLLAPPSGSIGDCsv 298
Cdd:cd14955  79 ADTGNHRIQKFDS-TGTFLTKWGSSGSGDGqfnsPSGIAVDSAG-NVYVTDSGNNRIqkfdssgTFITKWGSFGSGDG-- 154

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 27369692 299 vstiQLADqvlPHLLEVDrKTGAVYVAEIGAKQIQKY 335
Cdd:cd14955 155 ----QFNS---PTGIAVD-SAGNVYVADTGNNRIQKF 183
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 64-241 2.10e-16

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 78.08  E-value: 2.10e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  64 FCVAVDSlNGLVYVAQRGDNIpkVLVFSEDGYFLRA------WNYTVDTPHGMFV--SGTpfeqsVWITDVGsgpyGHTV 135
Cdd:cd14957 115 YGIAVDS-NGNIYVADTGNHR--IQVFTSSGTFSYSigsggtGPGQFNGPQGIAVdsDGN-----IYVADTG----NHRI 182

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 136 KKYNSLGDLVQVLGTPGKkGTGlnplQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNI 215
Cdd:cd14957 183 QVFTSSGTFQYTFGSSGS-GPG----QFSDPYGIAVDSDGNIYVADTG---NHRIQVFTSSGAYQYSIGTSGSGNGQFNY 254

                       170       180
                ....*....|....*....|....*.
gi 27369692 216 PHSVTLDAVGRVWVADRGNKRLQVFD 241
Cdd:cd14957 255 PYGIAVDNDGKIYVADSNNNRIQVFN 280
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 66-240 2.16e-16

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 78.36  E-value: 2.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGDNipKVLVFSEDGYFLRAWNYT------VDTPHGMFVSGtpfEQSVWITDVGSgpygHTVKKYN 139
Cdd:cd14954 123 VAVDS-EGRIYVSDTRNH--RVQVFDSDGQFIRKFGFEgagpgqLDSPRGVAVNP---DGNIVVSDFNN----HRLQVFD 192

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 140 SLGDLVQVLGTpgkKGTGlnPLQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSV 219
Cdd:cd14954 193 PDGQFLRFFGS---EGSG--NGQFKRPRGVAVDDEGNIIVADSG---NHRVQVFSPDGEFLCSFGTEGNGEGQFDRPSGV 264

                       170       180
                ....*....|....*....|.
gi 27369692 220 TLDAVGRVWVADRGNKRLQVF 240
Cdd:cd14954 265 AVTPDGRIVVVDRGNHRIQVF 285
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
66-337 1.19e-15

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 75.83  E-value: 1.19e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGDNipKVLVFS-EDGYFLRAWNYTVDTPHGMFVSGtpfEQSVWITDVGsgpyGHTVKKYNSLGDL 144
Cdd:COG4257  22 VAVDP-DGAVWFTDQGGG--RIGRLDpATGEFTEYPLGGGSGPHGIAVDP---DGNLWFTDNG----NNRIGRIDPKTGE 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 145 VQVLGTPGKKgtglnplqfDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDfmilwlRGE--NGTGPAKFNIPHSVTLD 222
Cdd:COG4257  92 ITTFALPGGG---------SNPHGIAFDPDGNLWFTDQG---GNRIGRLDPA------TGEvtEFPLPTGGAGPYGIAVD 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 223 AVGRVWVADRGNKRLQVFDKDTGEwLGAWDNCFTEEGPSAVRFTPDGKYLIVAQLNlSRLSVlLAPPSGSigdcsvVSTI 302
Cdd:COG4257 154 PDGNLWVTDFGANAIGRIDPDTGT-LTEYALPTPGAGPRGLAVDPDGNLWVADTGS-GRIGR-FDPKTGT------VTEY 224

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 27369692 303 QLAD-QVLPHLLEVDRKtGAVYVAEIGAKQIQKYIP 337
Cdd:COG4257 225 PLPGgGARPYGVAVDGD-GRVWFAESGANRIVRFDP 259
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-240 1.56e-15

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 75.70  E-value: 1.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSLNGLVYVAQRGDNipKVLVFSEDGYFLRAW--------------NYTVDtPHGmfvsgtpfeqSVWITDVGSGpy 131
Cdd:cd14962 105 IAVDPAGKRLYVVDTLAH--KVKVFDLDGRLLFDIgkrgsgpgefnlptDLAVD-RDG----------NLYVTDTMNF-- 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 132 ghTVKKYNSLGDLVQVLGTpgkkgTGLNPLQFDNPAELYVDDTGEMYIVDGDGglnNRLVKLSQDFMILWLRGENGTGPA 211
Cdd:cd14962 170 --RVQIFDADGKFLRSFGE-----RGDGPGSFARPKGIAVDSEGNIYVVDAAF---DNVQIFNPEGELLLTVGGPGSGPG 239

                       170       180
                ....*....|....*....|....*....
gi 27369692 212 KFNIPHSVTLDAVGRVWVADRGNKRLQVF 240
Cdd:cd14962 240 EFYLPSGIAIDKDDRIYVVDQFNRRIQVF 268
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
 152-335 1.23e-13

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 69.99  E-value: 1.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 152 GKKGTGLNplQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVTLDAVGRVWVAD 231
Cdd:cd14957   8 GSNGSGNG--QFNTPRGIAVDSAGNIYVADTG---NNRIQVFTSSGVYSYSIGSGGTGSGQFNSPYGIAVDSNGNIYVAD 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 232 RGNKRLQVFDKDTGEWL---GAWDNCFTEEGPSAVRFTPDGKyLIVAQLNLSRLSVLLAP--PSGSIGDcsvvSTIQLAD 306
Cdd:cd14957  83 TDNNRIQVFNSSGVYQYsigTGGSGDGQFNGPYGIAVDSNGN-IYVADTGNHRIQVFTSSgtFSYSIGS----GGTGPGQ 157

                       170       180
                ....*....|....*....|....*....
gi 27369692 307 QVLPHLLEVDRKtGAVYVAEIGAKQIQKY 335
Cdd:cd14957 158 FNGPQGIAVDSD-GNIYVADTGNHRIQVF 185
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-278 1.31e-13

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 70.01  E-value: 1.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDslNGLVYVAQRGDNipKVLVFSEDGYFLRA----------WNYtvdtPHGMFVSGtpfEQSVWITDVGSGpyghTV 135
Cdd:cd14963  15 VAVS--DGRIYVADTNNH--RVQVFDYEGKFKKSfggpgtgpgeFKY----PYGIAVDS---DGNIYVADLYNG----RI 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 136 KKYNSLGDLVQVLGTPGKKgtglnpLQFDNPAELYVDDtGEMYIVDGDGglnNRLVKLSQDFMILWLRGENGTGPAKFNI 215
Cdd:cd14963  80 QVFDPDGKFLKYFPEKKDR------VKLISPAGLAIDD-GKLYVSDVKK---HKVIVFDLEGKLLLEFGKPGSEPGELSY 149

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 27369692 216 PHSVTLDAVGRVWVADRGNKRLQVFDKDtGEWL----GAWDNCFTEEGPSAVRFTPDGKYLIVAQLN 278
Cdd:cd14963 150 PNGIAVDEDGNIYVADSGNGRIQVFDKN-GKFIkelnGSPDGKSGFVNPRGIAVDPDGNLYVVDNLS 215
NHL_like_3 cd14956
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 152-337 4.90e-13

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271326 [Multi-domain]  Cd Length: 274  Bit Score: 68.46  E-value: 4.90e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 152 GKKGTGlnPLQFDNP--------AELYVDDTGEMYI------------------------------VDGDGGL------N 187
Cdd:cd14956   3 GGRGSG--PGQFKDPrgiavdadDNVYVADARNGRIqvfdkdgtflrrfgttgdgpgqfgrprglaVDKDGWLyvadywG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 188 NRLVKLSQDFMILWLRGENGTGPAKFNIPHSVTLDAVGRVWVADRGNKRLQVFDKDtGEWLGAWDNCFTEEG----PSAV 263
Cdd:cd14956  81 DRIQVFTLTGELQTIGGSSGSGPGQFNAPRGVAVDADGNLYVADFGNQRIQKFDPD-GSFLRQWGGTGIEPGsfnyPRGV 159

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 27369692 264 RFTPDGKyLIVAQLNLSRLSVLLAppsgsigDCSVVSTI-----QLADQVLPHLLEVDRKtGAVYVAEIGAKQIQKYIP 337
Cdd:cd14956 160 AVDPDGT-LYVADTYNDRIQVFDN-------DGAFLRKWggrgtGPGQFNYPYGIAIDPD-GNVFVADFGNNRIQKFTA 229
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 66-236 1.55e-12

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 67.56  E-value: 1.55e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGDN-IPKV--------------LVFSEDGYFLRAwnyTVDTPHG--MFVSGTpfeqsVWITDVGS 128
Cdd:cd14953 137 VAVDA-AGNLYVADTGNHrIRKItpdgvvttvagtggAGYAGDGPATAA---QFNNPTGvaVDAAGN-----LYVADRGN 207

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 129 gpygHTVKKYNSLGDLVQVLGTPGK---KGTGLNPLQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDFMILWL--- 202
Cdd:cd14953 208 ----HRIRKITPDGVVTTVAGTGTAgfsGDGGATAAQLNNPTGVAVDAAGNLYVADSG---NHRIRKITPAGVVTTVagg 280

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 27369692 203 ----RGENGTG-PAKFNIPHSVTLDAVGRVWVADRGNKR 236
Cdd:cd14953 281 gagfSGDGGPAtSAQFNNPTGVAVDAAGNLYVADTGNNR 319
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 66-251 1.83e-11

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 63.76  E-value: 1.83e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGdnIPKVLVF------------SEDGYFLRAWNYTVDtPHGmfvsgtpfeqSVWITDVGSGpygh 133
Cdd:cd14962  17 VAADG-RGRIYVADTG--RGAVFVFdlpngkvfvignAGPNRFVSPIGVAID-ANG----------NLYVSDAELG---- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 134 TVKKYNSLGDLVQVLGtpgkkgtglNPLQFDNPAELYVD-DTGEMYIVDGdggLNNRLVKLSQDFMILWLRGENGTGPAK 212
Cdd:cd14962  79 KVFVFDRDGKFLRAIG---------AGALFKRPTGIAVDpAGKRLYVVDT---LAHKVKVFDLDGRLLFDIGKRGSGPGE 146

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 27369692 213 FNIPHSVTLDAVGRVWVADRGNKRLQVFDKDtGEWLGAW 251
Cdd:cd14962 147 FNLPTDLAVDRDGNLYVTDTMNFRVQIFDAD-GKFLRSF 184
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
216-329 2.19e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 63.17  E-value: 2.19e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 216 PHSVTLDAVG-RVWVADRGNKRLQVFDKDTGEWLGAWDncfTEEGPSAVRFTPDGKYLIVAQLNLSRLSVLLA---PPSG 291
Cdd:COG3391 112 PRGLAVDPDGgRLYVADSGNGRVSVIDTATGKVVATIP---VGAGPHGIAVDPDGKRLYVANSGSNTVSVIVSvidTATG 188

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 27369692 292 sigdcSVVSTIQLADQvlPHLLEVDRKTGAVYVAEIGA 329
Cdd:COG3391 189 -----KVVATIPVGGG--PVGVAVSPDGRRLYVANRGS 219
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
226-336 2.53e-11

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 62.79  E-value: 2.53e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 226 RVWVADRGNKRLQVFDKDTGEWLGAWDncfTEEGPSAVRFTPDGKYLIVAQLNLSRLSVLlappsgSIGDCSVVSTIQLA 305
Cdd:COG3391  81 RLYVANSGSGRVSVIDLATGKVVATIP---VGGGPRGLAVDPDGGRLYVADSGNGRVSVI------DTATGKVVATIPVG 151

                        90       100       110
                ....*....|....*....|....*....|.
gi 27369692 306 DQvlPHLLEVDRKTGAVYVAEIGAKQIQKYI 336
Cdd:COG3391 152 AG--PHGIAVDPDGKRLYVANSGSNTVSVIV 180
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 66-236 2.75e-11

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 63.70  E-value: 2.75e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGDN-IPKV----LV----------FSEDGYFLRAwnyTVDTPHGMFV--SGTpfeqsVWITDVGs 128
Cdd:cd14953  82 VAVDA-AGNLYVADTGNHrIRKItpdgVVstlagtgtagFSDDGGATAA---QFNYPTGVAVdaAGN-----LYVADTG- 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 129 gpyGHTVKKYNSLGDLVQVLGTPGKKGTGLNPL---QFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDFMI------ 199
Cdd:cd14953 152 ---NHRIRKITPDGVVTTVAGTGGAGYAGDGPAtaaQFNNPTGVAVDAAGNLYVADRG---NHRIRKITPDGVVttvagt 225

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 27369692 200 --LWLRGENGTGPAKFNIPHSVTLDAVGRVWVADRGNKR 236
Cdd:cd14953 226 gtAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHR 264
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
210-337 1.63e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 57.72  E-value: 1.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 210 PAKFNIPHSVTLDAVGRVWVADRGNKRLQVFDKDTGEWLGAWDNCFTeeGPSAVRFTPDGKyLIVAQLNLSRLsVLLAPP 289
Cdd:COG4257  13 PAPGSGPRDVAVDPDGAVWFTDQGGGRIGRLDPATGEFTEYPLGGGS--GPHGIAVDPDGN-LWFTDNGNNRI-GRIDPK 88

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 27369692 290 SGSIgdcsvvSTIQL-ADQVLPHLLEVDRKtGAVYVAEIGAKQIQKYIP 337
Cdd:COG4257  89 TGEI------TTFALpGGGSNPHGIAFDPD-GNLWFTDQGGNRIGRLDP 130
NHL_TRIM2_like cd14960
NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; ...
 152-274 1.86e-09

NHL repeat domain of the tripartite motif-containing protein 2 (TRIM2) and related proteins; The E3 ubiquitin-protein ligase TRIM2 is responsible for ubiquinating the apoptosis-inducing Bcl-2-interacting mediator of cell death (Bim), when the latter is phosphorylated by p42/p44 MAPK. TRIM2 regulates the ubiquitination of neurofilament light subunit (NF-L), deficiencies in TRIM2 result in increased NF-L levels in axons and subsequent axonopathy. TRIM2 is also involved in regulating axon outgrowth during development; it contains RING and BBOX domains, the NHL repeat domain is located at its C-terminus. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271330 [Multi-domain]  Cd Length: 274  Bit Score: 57.74  E-value: 1.86e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 152 GKKGTGLNplQFDNPAELYVDDTGEMYIVDgdggLNNRLVKL-SQDFMILWLRGENGTGPAKFNIPHSVTLDAVGRVWVA 230
Cdd:cd14960 143 GSRGNGDR--QFAGPHFAAVNNNNEIIVTD----FHNHSVKVfNAEGEFLFKFGSNGEGNGQFNAPTGVAVDSNGNIIVA 216

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 27369692 231 DRGNKRLQVFDKdTGEWLGAWDNCF-TEEGPSAVRFTPDGKYLIV 274
Cdd:cd14960 217 DWGNSRIQVFDS-SGSFLSYINTSAdPLYGPQGLALTSDGHVVVA 260
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
 149-236 2.97e-09

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 57.54  E-value: 2.97e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 149 GTPGKKGTGLNPLQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDFMILWLRG------ENGTGP-AKFNIPHSVTL 221
Cdd:cd14953   8 GTAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRG---NHRIRKITPDGVVTTVAGtgtagfADGGGAaAQFNTPSGVAV 84

                        90
                ....*....|....*
gi 27369692 222 DAVGRVWVADRGNKR 236
Cdd:cd14953  85 DAAGNLYVADTGNHR 99
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 207-332 2.40e-07

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 51.51  E-value: 2.40e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 207 GTGPAKFNIPHSVTLDAVGRVWVADRGNKRLQVFDKDtgewlgawdncfteeGPSAVRFTPDGKYlivAQLNLSRLSVLL 286
Cdd:cd14961   4 GGWPGTLNNPTGVAVTPTGRVVVADDGNKRIQVFDSD---------------GNCLQQFGPKGDA---GQDIRYPLDVAV 65

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 287 ApPSGSI-----GDCSV---------VSTIQLaDQVLPHLLEVDRKtGAVYVAEIGAKQI 332
Cdd:cd14961  66 T-PDGHIvvtdaGDRSVkvfsfdgrlKLFVRK-SFSLPWGVAVNPS-GEILVTDSEAGKL 122
NHL_TRIM71_like cd14954
NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; ...
 152-265 3.60e-07

NHL repeat domain of the tripartite motif-containing protein 71 (TRIM71) and related proteins; The E3 ubiquitin-protein ligase TRIM71 (LIN-41) is a RING-finger domain containing protein that has been associated with a variety of activities. The NHL repeat domain appears responsible for targeting TRIM71 to mRNAs, and TRIM71 appears responsible for translational repression and mRNA decay. Together with BRAT, TRIM71 may be part of a family of mRNA repressors that regulate proliferation and differentiation. TRIM has been shown to negatively regulate stability of Lin28B, which inhibits the pre-let-7 miRNA precursor from maturing by recruiting the terminal uriyltransferase TUT4. This family also contains the Caenorhabditis elegans NHL repeat containing 1 (NHL-1), a RING-finger-containing protein that was shown to interact with E2 ubiquitin conjugating enzymes in two-hybrid screens. Its domain architecture resembles that of the E3 ubiquitin protein ligases TRIM2, TRIM32, and TRIM71. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271324 [Multi-domain]  Cd Length: 285  Bit Score: 51.01  E-value: 3.60e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 152 GKKGTGlnPLQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVTLDAVGRVWVAD 231
Cdd:cd14954  14 GKEGSK--DGELCRPWGVAVDKDGRIIVADRS---NNRVQVFDPDGKFLRKFGSYGSRDGQFDRPAGVAVNSRGRIIVAD 88

                        90       100       110
                ....*....|....*....|....*....|....
gi 27369692 232 RGNKRLQVFDKDtGEWLGawdnCFTEEGPSAVRF 265
Cdd:cd14954  89 KDNHRIQVFDLN-GRFLL----KFGERGTKNGQF 117
NHL_brat_like cd14959
NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; ...
 195-274 4.20e-07

NHL repeat domain of the Drosophila brain-tumor protein (brat) and similar proteins; Drosophila brain-tumor (brat) has been identified as a tumor suppressor that negatively regulates cell proliferation during development of the Drosophila larval brain. It appears to be recruited to the 3'-untranslated region of hunchback RNA and regulates its translation by forming a complex with Pumilio (Pum) and Nanos (Nos). The NHL domain of brat appears to be involved by interacting with the RNA-binding Puf repeats of Pumilio, a sequence-specific RNA binding protein. This family also contains the Caenorhabditis elegans homolog NCL-1. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271329 [Multi-domain]  Cd Length: 274  Bit Score: 50.73  E-value: 4.20e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 195 QDFMILWLRGENGTGPAKFNIPHSVTLDAVGRVWVADRGNKRLQVFDKdTGEWLGAWDNCFTEEG----PSAVR-FTPDG 269
Cdd:cd14959   3 SKMIIHCKFGESGSGEGQFNSPSGFCLGEDEDILVADTNNHRIQVFDK-EGEFKFQFGIPGKRDGqlwyPNKVAvCRVTG 81


                ....*
gi 27369692 270 KYLIV 274
Cdd:cd14959  82 RYVVT 86
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 164-236 4.92e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.20  E-value: 4.92e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 27369692 164 DNPAELYVDDTGEMYIVDGDgglNNRLVKLsqdfmilwLRGENGTGPAKF---NIPHSVTLDAVGRVWVADRGNKR 236
Cdd:cd14952  52 YQPQGVAVDAAGTVYVTDFG---NNRVLKL--------AAGSTTQTVLPFtglNDPTGVAVDAAGNVYVADTGNNR 116
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 66-236 5.20e-06

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 47.20  E-value: 5.20e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGDN----------IPKVLVFSedgyflrawnyTVDTPHGMFVSGtpfEQSVWITDVGsgpyGHTV 135
Cdd:cd14952  99 VAVDA-AGNVYVADTGNNrvlklaagsnTQTVLPFT-----------GLSNPDGVAVDG---AGNVYVTDTG----NNRV 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 136 KKYNSLGDLVQVLgtPGkkgTGLNplqfdNPAELYVDDTGEMYIVDGDgglNNRLVKLSQdfmilwlrGENGTGPAKF-- 213
Cdd:cd14952 160 LKLAAGSTTQTVL--PF---TGLN-----SPSGVAVDTAGNVYVTDHG---NNRVLKLAA--------GSTTPTVLPFtg 218

                       170       180
                ....*....|....*....|....
gi 27369692 214 -NIPHSVTLDAVGRVWVADRGNKR 236
Cdd:cd14952 219 lNGPLGVAVDAAGNVYVADRGNDR 242
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 152-326 7.13e-06

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 46.89  E-value: 7.13e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 152 GKKGTGlnPLQFDNPAELYVDDTGEMYIVDgDGglNNRLVKLSQDFMILWLRGENGTGPAKFNIPHSVTLDAVGRVWVAD 231
Cdd:cd14961   1 GSFGGW--PGTLNNPTGVAVTPTGRVVVAD-DG--NKRIQVFDSDGNCLQQFGPKGDAGQDIRYPLDVAVTPDGHIVVTD 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 232 RGNKRLQVFDKDtGEWLGAWDNCFTEegPSAVRFTPDGKYLiVAQLNLSRLSVL-LAPPSGSIGDCSVVSTiQLadqVLP 310
Cdd:cd14961  76 AGDRSVKVFSFD-GRLKLFVRKSFSL--PWGVAVNPSGEIL-VTDSEAGKLFVLtVDFKLGILKKGQKLCS-QL---CRP 147

                       170
                ....*....|....*.
gi 27369692 311 HLLEVDRKtGAVYVAE 326
Cdd:cd14961 148 RFVAVSRL-GAVAVTE 162
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 59-236 1.65e-05

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 45.66  E-value: 1.65e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  59 FTGATFC--VAVDSlNGLVYVAQRGDN----------IPKVLVFSEdgyflrawnytVDTPHGMFVSGTpfeQSVWITDV 126
Cdd:cd14952   6 FTGLDGPggVAVDA-AGNVYVADSGNNrvlklaagstTQTVLPFTG-----------LYQPQGVAVDAA---GTVYVTDF 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 127 GSgpyghtvkkynslgDLVQVLgTPGkkGTGLNPLQF---DNPAELYVDDTGEMYIVDGDgglNNRLVKL---SQDFMIL 200
Cdd:cd14952  71 GN--------------NRVLKL-AAG--STTQTVLPFtglNDPTGVAVDAAGNVYVADTG---NNRVLKLaagSNTQTVL 130

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 27369692 201 WLRGENGtgpakfniPHSVTLDAVGRVWVADRGNKR 236
Cdd:cd14952 131 PFTGLSN--------PDGVAVDGAGNVYVTDTGNNR 158
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 118-335 1.99e-05

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 45.65  E-value: 1.99e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 118 EQSVWITDVgsgpYGHTVKKYNSLGDLVQVLGTPGKKGTGLnplqfdnpaelYVDDTGEMYIVDGDGGL------NNRLV 191
Cdd:COG3386  18 DGRLYWVDI----PGGRIHRYDPDGGAVEVFAEPSGRPNGL-----------AFDPDGRLLVADHGRGLvrfdpaDGEVT 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 192 KLSQDFmilwlrgengtgPAKFNIPHSVTLDAVGRVWVAD----RGNKRLQVFDKDtGEwLGAWDNCFTeeGPSAVRFTP 267
Cdd:COG3386  83 VLADEY------------GKPLNRPNDGVVDPDGRLYFTDmgeyLPTGALYRVDPD-GS-LRVLADGLT--FPNGIAFSP 146

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 27369692 268 DGKYLIVAQLNLSRLSVLLAPPSGSIGDCSVVSTIQlADQVLPHLLEVDRKtGAVYVAEIGAKQIQKY 335
Cdd:COG3386 147 DGRTLYVADTGAGRIYRFDLDADGTLGNRRVFADLP-DGPGGPDGLAVDAD-GNLWVALWGGGGVVRF 212
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
64-245 5.57e-05

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 44.24  E-value: 5.57e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  64 FCVAVDSlNGLVYVAQRGDNipKVLVFS-EDGYFlRAWNYTVD--TPHGMFVSGtpfEQSVWITDVGsgpyGHTVKKYNS 140
Cdd:COG4257 105 HGIAFDP-DGNLWFTDQGGN--RIGRLDpATGEV-TEFPLPTGgaGPYGIAVDP---DGNLWVTDFG----ANAIGRIDP 173

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 141 LGDLVQVLGTPGkkgtglnplQFDNPAELYVDDTGEMYIVDGDgglNNRLVKLSqdfmilwlrGENGT-----GPAKFNI 215
Cdd:COG4257 174 DTGTLTEYALPT---------PGAGPRGLAVDPDGNLWVADTG---SGRIGRFD---------PKTGTvteypLPGGGAR 232

                       170       180       190
                ....*....|....*....|....*....|
gi 27369692 216 PHSVTLDAVGRVWVADRGNKRLQVFDKDTG 245
Cdd:COG4257 233 PYGVAVDGDGRVWFAESGANRIVRFDPDTE 262
NHL pfam01436
NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is ...
 213-240 6.81e-05

NHL repeat; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies. It is about 40 residues long and resembles the WD repeat pfam00400. The repeats have a catalytic activity in Swiss:P10731, proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Swiss:Q13049 interacts with the activation domain of Tat. This interaction is me diated by the NHL repeats.


Pssm-ID: 396153 [Multi-domain]  Cd Length: 28  Bit Score: 39.31  E-value: 6.81e-05
                          10        20
                  ....*....|....*....|....*...
gi 27369692   213 FNIPHSVTLDAVGRVWVADRGNKRLQVF 240
Cdd:pfam01436   1 FNRPHGVAVDSNGDIYVADSENHRVQVF 28
NHL_TRIM32_like cd14961
NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; ...
 66-275 8.94e-05

NHL repeat domain of the tripartite motif-containing protein 32 (TRIM32) and related proteins; The E3 ubiquitin-protein ligase TRIM32 (HT2A) is widely expressed and is responsible for ubiquinating a large variety of targets, including dysbindin (DTNBP1), NPHP7/Glis2, TAp73, and others. TRIM32 promotes disassociation of the plakoglobin-PI3K complex and reduces PI3K-Akt-FoxO signaling. Mutations in TRIM32 have been implemented in the two diverse diseases limb-girdle muscular dystrophy type 2H (LGMD2H) or sarcotubular myopathy (STM) and Bardet-Biedl syndrome type 11 (BBS11). The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271331 [Multi-domain]  Cd Length: 273  Bit Score: 43.42  E-value: 8.94e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQRGDNipKVLVFSEDGY--------FLRAWNYTVDtPHGMFVsgtpfeqsvwITDVGSGPYGHTVKK 137
Cdd:cd14961  63 VAVTP-DGHIVVTDAGDR--SVKVFSFDGRlklfvrksFSLPWGVAVN-PSGEIL----------VTDSEAGKLFVLTVD 128

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 138 YNslgdlVQVLGTPGKKGTGLNplqfdNPAELYVDDTGEMYIVDGDGGLNNRL----VKLSQDFMILW----LRGeNGTG 209
Cdd:cd14961 129 FK-----LGILKKGQKLCSQLC-----RPRFVAVSRLGAVAVTEHLFANGTRSsstrVKVFSSGGQLLgqidSFG-LNLV 197

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 27369692 210 PAKFNIPHSVTLDAVGRVWVADRGNKRLQVFDKDTGEWlgawdnCFTEE------GPSAVRFTPDGkYLIVA 275
Cdd:cd14961 198 FPSLICASGVAFDSEGNVIVADTGSGAILCLGKPEGFP------ILKPIvtqglsRPVGLAVTPDG-SLVVL 262
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 66-236 1.22e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.97  E-value: 1.22e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  66 VAVDSlNGLVYVAQ----------RGDNIPKVLVFSEdgyflrawnytVDTPHGMFVSGtpfEQSVWITDVGSGpyghTV 135
Cdd:cd14952  57 VAVDA-AGTVYVTDfgnnrvlklaAGSTTQTVLPFTG-----------LNDPTGVAVDA---AGNVYVADTGNN----RV 117

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 136 KKYNSLGDLVQVLGTpgkkgTGLNplqfdNPAELYVDDTGEMYIVDGDgglNNRLVKLSQDfmilwlrgenGTGPAKF-- 213
Cdd:cd14952 118 LKLAAGSNTQTVLPF-----TGLS-----NPDGVAVDGAGNVYVTDTG---NNRVLKLAAG----------STTQTVLpf 174

                       170       180
                ....*....|....*....|....*.
gi 27369692 214 ---NIPHSVTLDAVGRVWVADRGNKR 236
Cdd:cd14952 175 tglNSPSGVAVDTAGNVYVTDHGNNR 200
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
 204-335 1.59e-04

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 42.57  E-value: 1.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 204 GENGTGPAkFNIPHSVTLDAVGRVWVADRGNKRLQVFDKDTGE---WLGAWDNCFTEegPSAVRFTPDGKyLIVAQLNLS 280
Cdd:cd14962   3 GEERPKEA-LTRPYGVAADGRGRIYVADTGRGAVFVFDLPNGKvfvIGNAGPNRFVS--PIGVAIDANGN-LYVSDAELG 78

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 27369692 281 RLSVLLAP--PSGSIGdcsvvstiQLADQVLPHLLEVDRKTGAVYVAEIGAKQIQKY 335
Cdd:cd14962  79 KVFVFDRDgkFLRAIG--------AGALFKRPTGIAVDPAGKRLYVVDTLAHKVKVF 127
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
 156-237 2.37e-04

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 42.19  E-value: 2.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 156 TGLnplqfDNPAELYVDDTGEMYIVDGDgglNNRLVKLSQdfmilwlrGENGTGPAKFN---IPHSVTLDAVGRVWVADR 232
Cdd:cd14952   7 TGL-----DGPGGVAVDAAGNVYVADSG---NNRVLKLAA--------GSTTQTVLPFTglyQPQGVAVDAAGTVYVTDF 70


                ....*
gi 27369692 233 GNKRL 237
Cdd:cd14952  71 GNNRV 75
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 169-274 7.17e-04

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 40.65  E-value: 7.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 169 LYVDDTGEMYI----VDGDGGLNNRLVklsqdfmilWLRGENGTGpakfnIPHSVTLDAVGRVWVADRGNKRLQVFDKDt 244
Cdd:COG3386 151 LYVADTGAGRIyrfdLDADGTLGNRRV---------FADLPDGPG-----GPDGLAVDADGNLWVALWGGGGVVRFDPD- 215

                        90       100       110
                ....*....|....*....|....*....|.
gi 27369692 245 GEWLGAWDncFTEEGPSAVRF-TPDGKYLIV 274
Cdd:COG3386 216 GELLGRIE--LPERRPTNVAFgGPDLRTLYV 244
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
 209-293 1.09e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 40.26  E-value: 1.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 209 GPAKFNIPHSVTLDAVGRVWVADRGNKRLQVFDKDTGEWlGAWDncFTEEGPSAVRFTPDGKyLIVAQlNLSRLsVLLAP 288
Cdd:COG3386   3 ADAGFRLGEGPVWDPDGRLYWVDIPGGRIHRYDPDGGAV-EVFA--EPSGRPNGLAFDPDGR-LLVAD-HGRGL-VRFDP 76


                ....*
gi 27369692 289 PSGSI 293
Cdd:COG3386  77 ADGEV 81
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
75-245 5.65e-03

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 37.75  E-value: 5.65e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692  75 VYVAQRGDNipKVLVF-SEDGYFLRAWnYTVDTPHGMFVSgtPFEQSVWITDVGSgpygHTVKKYN-SLGDLVQVLGTPg 152
Cdd:COG3391  82 LYVANSGSG--RVSVIdLATGKVVATI-PVGGGPRGLAVD--PDGGRLYVADSGN----GRVSVIDtATGKVVATIPVG- 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27369692 153 kkgtglnplqfDNPAELYVD-DTGEMYIVDGDgglNNRLVKLsqdfmILWLRGENGTGPAKFNI---PHSVTLDAVGR-V 227
Cdd:COG3391 152 -----------AGPHGIAVDpDGKRLYVANSG---SNTVSVI-----VSVIDTATGKVVATIPVgggPVGVAVSPDGRrL 212

                       170       180
                ....*....|....*....|....*
gi 27369692 228 WVADRGN-------KRLQVFDKDTG 245
Cdd:COG3391 213 YVANRGSntsnggsNTVSVIDLATL 237
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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