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Conserved domains on  [gi|27370506|ref|NP_766590|]
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zinc finger protein ZXDC isoform 2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C2H2_8 super family cl25789
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 241-318 3.35e-06

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


The actual alignment was detected with superfamily member pfam15909:

Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 46.26  E-value: 3.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506   241 CPVGGCGKKFTTVYNLKAHMKGH------EQESLFKCEV--CAERFPTHAKLNSHQRSHFEPERPYKCDfpGCEKTFITV 312
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFKCE--NCLLRFRTH 79


                  ....*.
gi 27370506   313 SALFSH 318
Cdd:pfam15909  80 RSLFKH 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-363 1.14e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 1.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 176 YRCPEPQCALSFAKKHQLKVHL-LTHGSLQGRRPFKCPLDGCGWAFTTSYKLKRHLQSHDKLRPFSCPVGGCGKKFttvy 254
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLrSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKF---- 363

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 255 NLKAHMKGHEQeslfkcevcaerfpthaklnSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREQELfSCSFP 334
Cdd:COG5048 364 SPLLNNEPPQS--------------------LQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPY-NCKNP 422

                       170       180
                ....*....|....*....|....*....
gi 27370506 335 GCNKQYDKACRLKIHLRSHTGERPFICDS 363
Cdd:COG5048 423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
392-691 2.24e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 2.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 392 PVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFSARSSLYIHSKKHLQDvgtPKSRCPVSSCNRLFTSKHSMKA 471
Cdd:COG5048  35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNN---PSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 472 hvvrqHSRRQDLVPQLEAPSSLTPSSELSSPgQSELTNIDLaaLFSDTPANSSSSTAgsdealnsgiltidvTSVSSSLG 551
Cdd:COG5048 112 -----SSSSNSNDNNLLSSHSLPPSSRDPQL-PDLLSISNL--RNNPLPGNNSSSVN---------------TPQSNSLH 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 552 GNLPTNNNSLGPMDPLVLVAHGDMPPSLDSPLVLGTSATVLQPGSFSADDSQAMSTGAVGCLVALPVRNLNQDSPaltps 631
Cdd:COG5048 169 PPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ----- 243

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 632 nnltaPGTTPTSSDTTQETGSVPDLLVPIKVEQDLSPVPDVVQGQKESHGPSQSVLSSST 691
Cdd:COG5048 244 -----SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNIS 298
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-402 7.32e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.32e-03
                          10        20
                  ....*....|....*....|....*..
gi 27370506   376 LLRHKRKHDDDRRFTCPVegCGKSFTR 402
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
 
Name Accession Description Interval E-value
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 241-318 3.35e-06

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 46.26  E-value: 3.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506   241 CPVGGCGKKFTTVYNLKAHMKGH------EQESLFKCEV--CAERFPTHAKLNSHQRSHFEPERPYKCDfpGCEKTFITV 312
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFKCE--NCLLRFRTH 79


                  ....*.
gi 27370506   313 SALFSH 318
Cdd:pfam15909  80 RSLFKH 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-363 1.14e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 1.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 176 YRCPEPQCALSFAKKHQLKVHL-LTHGSLQGRRPFKCPLDGCGWAFTTSYKLKRHLQSHDKLRPFSCPVGGCGKKFttvy 254
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLrSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKF---- 363

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 255 NLKAHMKGHEQeslfkcevcaerfpthaklnSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREQELfSCSFP 334
Cdd:COG5048 364 SPLLNNEPPQS--------------------LQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPY-NCKNP 422

                       170       180
                ....*....|....*....|....*....
gi 27370506 335 GCNKQYDKACRLKIHLRSHTGERPFICDS 363
Cdd:COG5048 423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
392-691 2.24e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 2.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 392 PVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFSARSSLYIHSKKHLQDvgtPKSRCPVSSCNRLFTSKHSMKA 471
Cdd:COG5048  35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNN---PSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 472 hvvrqHSRRQDLVPQLEAPSSLTPSSELSSPgQSELTNIDLaaLFSDTPANSSSSTAgsdealnsgiltidvTSVSSSLG 551
Cdd:COG5048 112 -----SSSSNSNDNNLLSSHSLPPSSRDPQL-PDLLSISNL--RNNPLPGNNSSSVN---------------TPQSNSLH 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 552 GNLPTNNNSLGPMDPLVLVAHGDMPPSLDSPLVLGTSATVLQPGSFSADDSQAMSTGAVGCLVALPVRNLNQDSPaltps 631
Cdd:COG5048 169 PPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ----- 243

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 632 nnltaPGTTPTSSDTTQETGSVPDLLVPIKVEQDLSPVPDVVQGQKESHGPSQSVLSSST 691
Cdd:COG5048 244 -----SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNIS 298
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 237-292 1.09e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 1.09e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27370506 237 RPFSCPVGGCGKKFTTVYNLKAHMK-GHEQESL------------------FKCEVCAERFPTHAKLNSHqRSHF 292
Cdd:COG5189 348 KPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQKLhenpspekmnifsakdkpYRCEVCDKRYKNLNGLKYH-RKHS 421
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 230-268 4.19e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 4.19e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 27370506 230 LQSHDKLRPFSCPVggCGKKFTTVYNLKAHMKGHEQESL 268
Cdd:cd20908  17 LIQHQKAKHFKCHI--CHKKLYTAGGLAVHCLQVHKETL 53
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 209-233 5.37e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.37e-03
                          10        20
                  ....*....|....*....|....*
gi 27370506   209 FKCPldGCGWAFTTSYKLKRHLQSH 233
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-402 7.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.32e-03
                          10        20
                  ....*....|....*....|....*..
gi 27370506   376 LLRHKRKHDDDRRFTCPVegCGKSFTR 402
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 361-439 8.39e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 36.63  E-value: 8.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506   361 CDSDSCGWTFTSMSKLLRHKRKHD------DDRRFTCPVEGCGKSFTRAEHLKGHSITHLG-TKPFECpvEGCCARFSAR 433
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCpptqslEGKLFRCSALSCTETFPSMQELVAHSKLHYKpNRYFKC--ENCLLRFRTH 79


                  ....*.
gi 27370506   434 SSLYIH 439
Cdd:pfam15909  80 RSLFKH 85
 
Name Accession Description Interval E-value
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 241-318 3.35e-06

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 46.26  E-value: 3.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506   241 CPVGGCGKKFTTVYNLKAHMKGH------EQESLFKCEV--CAERFPTHAKLNSHQRSHFEPERPYKCDfpGCEKTFITV 312
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHcpptqsLEGKLFRCSAlsCTETFPSMQELVAHSKLHYKPNRYFKCE--NCLLRFRTH 79


                  ....*.
gi 27370506   313 SALFSH 318
Cdd:pfam15909  80 RSLFKH 85
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
176-363 1.14e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 1.14e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 176 YRCPEPQCALSFAKKHQLKVHL-LTHGSLQGRRPFKCPLDGCGWAFTTSYKLKRHLQSHDKLRPFSCPVGGCGKKFttvy 254
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLrSVNHSGESLKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKF---- 363

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 255 NLKAHMKGHEQeslfkcevcaerfpthaklnSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREQELfSCSFP 334
Cdd:COG5048 364 SPLLNNEPPQS--------------------LQQYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPY-NCKNP 422

                       170       180
                ....*....|....*....|....*....
gi 27370506 335 GCNKQYDKACRLKIHLRSHTGERPFICDS 363
Cdd:COG5048 423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSI 451
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
392-691 2.24e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 2.24e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 392 PVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFSARSSLYIHSKKHLQDvgtPKSRCPVSSCNRLFTSKHSMKA 471
Cdd:COG5048  35 SCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNN---PSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 472 hvvrqHSRRQDLVPQLEAPSSLTPSSELSSPgQSELTNIDLaaLFSDTPANSSSSTAgsdealnsgiltidvTSVSSSLG 551
Cdd:COG5048 112 -----SSSSNSNDNNLLSSHSLPPSSRDPQL-PDLLSISNL--RNNPLPGNNSSSVN---------------TPQSNSLH 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 552 GNLPTNNNSLGPMDPLVLVAHGDMPPSLDSPLVLGTSATVLQPGSFSADDSQAMSTGAVGCLVALPVRNLNQDSPaltps 631
Cdd:COG5048 169 PPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQ----- 243

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 632 nnltaPGTTPTSSDTTQETGSVPDLLVPIKVEQDLSPVPDVVQGQKESHGPSQSVLSSST 691
Cdd:COG5048 244 -----SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFSLPIKSKQCNIS 298
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 237-292 1.09e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 1.09e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 27370506 237 RPFSCPVGGCGKKFTTVYNLKAHMK-GHEQESL------------------FKCEVCAERFPTHAKLNSHqRSHF 292
Cdd:COG5189 348 KPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQKLhenpspekmnifsakdkpYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 145-261 1.29e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.48  E-value: 1.29e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 145 SLHPATTPGLEPSSAAASRRGPVAASAGSPAYRCPEPQCALSFAKKHQLKVHLLTHGSLQ---GRRPFKCPLDGCGWAFT 221
Cdd:COG5189 283 SSLGFDYEFIHKSVGNKEIRGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNIDTPSRMLkvkDGKPYKCPVEGCNKKYK 362

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 27370506 222 TSYKLKRHL---------------QSHD----KLRPFSCPVggCGKKFTTVYNLKAHMK 261
Cdd:COG5189 363 NQNGLKYHMlhghqnqklhenpspEKMNifsaKDKPYRCEV--CDKRYKNLNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-527 1.86e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.07  E-value: 1.86e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 284 LNSHQRSHFEPERPYKCDFPGCEKTFITVSALFSHNRAHFREqelfSCSFPGCNKQYDKACRLKIHLRSHTGERPF--IC 361
Cdd:COG5048 215 SSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSS----ASESPRSSLPTASSQSSSPNESDSSSEKGFslPI 290

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 362 DSDSCGWTFTSMSKLLRHKRKHDDD----RRFTCPVEGCGKSFTRAEHLKGHSITHLGTKPFECPVEGCCARFS----AR 433
Cdd:COG5048 291 KSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSpllnNE 370

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 434 SSLYIHSKKHLqdVGTPKSRCPVSSCNRLFTSKHSMKAHVVRQHSRRQDLVPQLEAPSSLTPSSELSSPGQSELTNIDLa 513
Cdd:COG5048 371 PPQSLQQYKDL--KNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPL- 447

                       250
                ....*....|....
gi 27370506 514 aLFSDTPANSSSST 527
Cdd:COG5048 448 -LCSILKSFRRDLD 460
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 178-287 1.53e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.94  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506   178 CPEPQCALSFAKKHQLKVHLLTHgslqgrrpfkCPldgcgwaftTSYKLKRHLqshdklrpFSCPVGGCGKKFTTVYNLK 257
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTH----------CP---------PTQSLEGKL--------FRCSALSCTETFPSMQELV 54

                          90       100       110
                  ....*....|....*....|....*....|.
gi 27370506   258 AHMKGHEQES-LFKCEVCAERFPTHAKLNSH 287
Cdd:pfam15909  55 AHSKLHYKPNrYFKCENCLLRFRTHRSLFKH 85
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
209-336 2.07e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 41.54  E-value: 2.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 209 FKCPLDGCGWAFTTSYKLKRHLQS-HDKLRPFSCpvGGCGKKFT---TVYN---LKAHMKGHEQESLFK----CEVCAER 277
Cdd:COG5236 152 FKCPKSKCHRRCGSLKELKKHYKAqHGFVLCSEC--IGNKKDFWneiRLFRsstLRDHKNGGLEEEGFKghplCIFCKIY 229

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 27370506 278 FPTHAKLNSHQRShfEPERPYKCDF--PGCEKTFITVSALFshnrAHFREQElFSCSFPGC 336
Cdd:COG5236 230 FYDDDELRRHCRL--RHEACHICDMvgPIRYQYFKSYEDLE----AHFRNAH-YCCTFQTC 283
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
317-560 3.99e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.45  E-value: 3.99e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 317 SHNRAHFREQELFSCSF-PGCNKQYDKACRLKIHLRSHTGERPFICDSDSCGWTFTSMSKLLRHKRKHDDDRRFTCPVEG 395
Cdd:COG5048  19 TPKSTLKSLSNAPRPDScPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSL 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 396 CGKSFTRAEHLKGHSITHlgtkpfecpvegccarFSARSSLYIHSKKHLQDVgtpKSRCPVSSCNRLFTSKHSMKAHVVR 475
Cdd:COG5048  99 PLSNSKASSSSLSSSSSN----------------SNDNNLLSSHSLPPSSRD---PQLPDLLSISNLRNNPLPGNNSSSV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506 476 QHSRRQDLVPQLEAPSSLT-PSSELSSPGQSELTNI-----DLAALFSDTPANSSSSTAGSDEALNSGILTIDVTSVSSS 549
Cdd:COG5048 160 NTPQSNSLHPPLPANSLSKdPSSNLSLLISSNVSTSipsssENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKS 239

                       250
                ....*....|.
gi 27370506 550 LGGNLPTNNNS 560
Cdd:COG5048 240 LLSQSPSSLSS 250
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 230-268 4.19e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 4.19e-03
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 27370506 230 LQSHDKLRPFSCPVggCGKKFTTVYNLKAHMKGHEQESL 268
Cdd:cd20908  17 LIQHQKAKHFKCHI--CHKKLYTAGGLAVHCLQVHKETL 53
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 209-233 5.37e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.37e-03
                          10        20
                  ....*....|....*....|....*
gi 27370506   209 FKCPldGCGWAFTTSYKLKRHLQSH 233
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 239-263 6.04e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 6.04e-03
                          10        20
                  ....*....|....*....|....*
gi 27370506   239 FSCPvgGCGKKFTTVYNLKAHMKGH 263
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-402 7.32e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.32e-03
                          10        20
                  ....*....|....*....|....*..
gi 27370506   376 LLRHKRKHDDDRRFTCPVegCGKSFTR 402
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 361-439 8.39e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 36.63  E-value: 8.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27370506   361 CDSDSCGWTFTSMSKLLRHKRKHD------DDRRFTCPVEGCGKSFTRAEHLKGHSITHLG-TKPFECpvEGCCARFSAR 433
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCpptqslEGKLFRCSALSCTETFPSMQELVAHSKLHYKpNRYFKC--ENCLLRFRTH 79


                  ....*.
gi 27370506   434 SSLYIH 439
Cdd:pfam15909  80 RSLFKH 85
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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