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Conserved domains on  [gi|27886541|ref|NP_775114|]
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nuclear factor of activated T-cells, cytoplasmic 2 isoform C [Homo sapiens]

Protein Classification

RHD-n_NFAT and IPT_NFAT domain-containing protein( domain architecture ID 10167651)

protein containing domains PHA03247, RHD-n_NFAT, and IPT_NFAT

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RHD-n_NFAT cd07881
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
398-572 4.85e-125

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development.


:

Pssm-ID: 143641  Cd Length: 175  Bit Score: 375.30  E-value: 4.85e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 398 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVH 477
Cdd:cd07881   1 DWPLPSQSGQYELRIEVQPKPHHRAHYETEGSRGAVKASTGGHPVVQLHGYMENKPLTLQMFIGTADDRYLRPHAFYQVH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 478 RITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRI 557
Cdd:cd07881  81 RITGKTVATASQEIIISNTKVLEIPLLPENNMRASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGRV 160
                       170
                ....*....|....*
gi 27886541 558 VSLQTASNPIECSQR 572
Cdd:cd07881 161 LSLQVASNPIECSQR 175
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
577-677 1.20e-54

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


:

Pssm-ID: 238583  Cd Length: 101  Bit Score: 184.23  E-value: 1.20e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 577 LPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKV 656
Cdd:cd01178   1 LPEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGQDGEAQWEAEATIDKEKSHQNHLVVEVPPYHNKHVAAPVQV 80
                        90       100
                ....*....|....*....|.
gi 27886541 657 NFYVINGKRKRSQPQHFTYHP 677
Cdd:cd01178  81 QFYVVNGKRKRSQPQTFTYTP 101
PHA03247 super family cl33720
large tegument protein UL36; Provisional
4-442 5.72e-04

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541     4 PERQPQPDGGDAPGHEPGGSPQDeldfsilfdyeyLNPNEEEPNAHKVASPPSGPAYPDDVLDYGlkpySPLASLSGEPP 83
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGP------------APPSPLPPDTHAPDPPPPSPSPAANEPDPH----PPPTVPPPERP 2652
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541    84 GRFGEPDRVG-PQKFLSAAKPAGASglSPRIEITPShELIQAVGPLRMrdagllVEQPPLAGVAASPRFTLPVPGFegyr 162
Cdd:PHA03247 2653 RDDPAPGRVSrPRRARRLGRAAQAS--SPPQRPRRR-AARPTVGSLTS------LADPPPPPPTPEPAPHALVSAT---- 2719
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   163 ePLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLC-PQFQNIPAHYSPRTSPIMSPRTSLaedsclgrhspvPRP 241
Cdd:PHA03247 2720 -PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArPPTTAGPPAPAPPAAPAAGPPRRL------------TRP 2786
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   242 ASRSSSPGAKR----RHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALnslatdSPCG 317
Cdd:PHA03247 2787 AVASLSESRESlpspWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV------APGG 2860
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   318 iPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEflgpceqgerrnSAPESILLVPPTWPKPLVPAIPICSIPV-TASLPP 396
Cdd:PHA03247 2861 -DVRRRPPSRSPAAKPAAPARPPVRRLARPAVS------------RSTESFALPPDQPERPPQPQAPPPPQPQpQPPPPP 2927
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 27886541   397 LEWPLSSQSGsyelRIEVQPKPHHRAHYETEGSrGAVKAPTGGHPV 442
Cdd:PHA03247 2928 QPQPPPPPPP----RPQPPLAPTTDPAGAGEPS-GAVPQPWLGALV 2968
 
Name Accession Description Interval E-value
RHD-n_NFAT cd07881
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
398-572 4.85e-125

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development.


Pssm-ID: 143641  Cd Length: 175  Bit Score: 375.30  E-value: 4.85e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 398 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVH 477
Cdd:cd07881   1 DWPLPSQSGQYELRIEVQPKPHHRAHYETEGSRGAVKASTGGHPVVQLHGYMENKPLTLQMFIGTADDRYLRPHAFYQVH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 478 RITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRI 557
Cdd:cd07881  81 RITGKTVATASQEIIISNTKVLEIPLLPENNMRASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGRV 160
                       170
                ....*....|....*
gi 27886541 558 VSLQTASNPIECSQR 572
Cdd:cd07881 161 LSLQVASNPIECSQR 175
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
577-677 1.20e-54

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 184.23  E-value: 1.20e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 577 LPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKV 656
Cdd:cd01178   1 LPEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGQDGEAQWEAEATIDKEKSHQNHLVVEVPPYHNKHVAAPVQV 80
                        90       100
                ....*....|....*....|.
gi 27886541 657 NFYVINGKRKRSQPQHFTYHP 677
Cdd:cd01178  81 QFYVVNGKRKRSQPQTFTYTP 101
RHD_DNA_bind pfam00554
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ...
410-570 4.14e-31

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.


Pssm-ID: 425749  Cd Length: 169  Bit Score: 120.10  E-value: 4.14e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   410 LRIEVQPKPH-HRAHYETEG-SRGAVKAP-----TGGHPVVQLHGYMEnkPLGLQIFIGTADERiLKPHAfyqvHRITGK 482
Cdd:pfam00554   1 LEIVEQPKQRgMRFRYKCEGrSAGSIPGEsstrsKKTFPTVQICNYDG--PAVIRVSLVTKDEP-HRPHP----HSLVGK 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   483 TVtttsyekivgNTKVLEIPLEPKNnMRATIDCAGILKLRNADIELRKGE---TDIGRKN--------------TRVRLV 545
Cdd:pfam00554  74 DC----------KDGVCEVELGPED-MVASFQNLGIQCVKKKDVEEALKErieLNIDPFNvgfealrqikdmdlNVVRLC 142
                         170       180
                  ....*....|....*....|....*..
gi 27886541   546 FRVHIPESSGRIV--SLQTASNPIECS 570
Cdd:pfam00554 143 FQAFLPDTRGNFTtpLPPVVSNPIYDK 169
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
579-677 2.05e-30

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 465045  Cd Length: 102  Bit Score: 115.35  E-value: 2.05e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   579 MVERQDTDSCLVYGGQQMILTGQNFTSE-SKVVFTEKtTDGQQIWEMEATVDKDKSQPNM-LFVEIPEYRNKHIRTPVKV 656
Cdd:pfam16179   1 KICRLSLCSGSVTGGEEIILLCEKVLKDdIKVRFYEE-DDGQEVWEAEGDFSKTDVHRQVaIVFKTPPYRDPDITEPVTV 79
                          90       100
                  ....*....|....*....|..
gi 27886541   657 NFYVINGKRK-RSQPQHFTYHP 677
Cdd:pfam16179  80 NIQLRRPSDKaTSEPQPFTYLP 101
IPT smart00429
ig-like, plexins, transcription factors;
577-676 3.24e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 68.99  E-value: 3.24e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541    577 LPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKttdgqqIWEMEATVDKDKSqpNMLFVEIPEYRNKHIRTPVKv 656
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVG------VGEAPCTFSPSSS--TAIVCKTPPYHNIPGSVPVR- 71
                           90       100
                   ....*....|....*....|
gi 27886541    657 NFYVINGKRkRSQPQHFTYH 676
Cdd:smart00429  72 TVGLRNGGV-PSSPQPFTYV 90
PHA03247 PHA03247
large tegument protein UL36; Provisional
4-442 5.72e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541     4 PERQPQPDGGDAPGHEPGGSPQDeldfsilfdyeyLNPNEEEPNAHKVASPPSGPAYPDDVLDYGlkpySPLASLSGEPP 83
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGP------------APPSPLPPDTHAPDPPPPSPSPAANEPDPH----PPPTVPPPERP 2652
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541    84 GRFGEPDRVG-PQKFLSAAKPAGASglSPRIEITPShELIQAVGPLRMrdagllVEQPPLAGVAASPRFTLPVPGFegyr 162
Cdd:PHA03247 2653 RDDPAPGRVSrPRRARRLGRAAQAS--SPPQRPRRR-AARPTVGSLTS------LADPPPPPPTPEPAPHALVSAT---- 2719
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   163 ePLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLC-PQFQNIPAHYSPRTSPIMSPRTSLaedsclgrhspvPRP 241
Cdd:PHA03247 2720 -PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArPPTTAGPPAPAPPAAPAAGPPRRL------------TRP 2786
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   242 ASRSSSPGAKR----RHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALnslatdSPCG 317
Cdd:PHA03247 2787 AVASLSESRESlpspWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV------APGG 2860
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   318 iPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEflgpceqgerrnSAPESILLVPPTWPKPLVPAIPICSIPV-TASLPP 396
Cdd:PHA03247 2861 -DVRRRPPSRSPAAKPAAPARPPVRRLARPAVS------------RSTESFALPPDQPERPPQPQAPPPPQPQpQPPPPP 2927
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 27886541   397 LEWPLSSQSGsyelRIEVQPKPHHRAHYETEGSrGAVKAPTGGHPV 442
Cdd:PHA03247 2928 QPQPPPPPPP----RPQPPLAPTTDPAGAGEPS-GAVPQPWLGALV 2968
 
Name Accession Description Interval E-value
RHD-n_NFAT cd07881
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
398-572 4.85e-125

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development.


Pssm-ID: 143641  Cd Length: 175  Bit Score: 375.30  E-value: 4.85e-125
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 398 EWPLSSQSGSYELRIEVQPKPHHRAHYETEGSRGAVKAPTGGHPVVQLHGYMENKPLGLQIFIGTADERILKPHAFYQVH 477
Cdd:cd07881   1 DWPLPSQSGQYELRIEVQPKPHHRAHYETEGSRGAVKASTGGHPVVQLHGYMENKPLTLQMFIGTADDRYLRPHAFYQVH 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 478 RITGKTVTTTSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRI 557
Cdd:cd07881  81 RITGKTVATASQEIIISNTKVLEIPLLPENNMRASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGRV 160
                       170
                ....*....|....*
gi 27886541 558 VSLQTASNPIECSQR 572
Cdd:cd07881 161 LSLQVASNPIECSQR 175
RHD-n_NFAT_like cd07927
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
408-571 1.59e-83

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins and similar proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development. This group also contains the N-terminal RHD sub-domain of the non-calcium regulated tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.


Pssm-ID: 143648  Cd Length: 161  Bit Score: 265.68  E-value: 1.59e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 408 YELRIEVQPKPHHRAHYETEGSRGAVKAPT-GGHPVVQLHGYMEnkPLGLQIFIGTADERiLKPHAFYQVHRITGKTvTT 486
Cdd:cd07927   1 YELRIEVQPEPHHRARYETEGSRGAVKAPStGGFPTVKLHGYME--PVGLQVFIGTASGR-LKPHAFYQVHRITGKT-TT 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 487 TSYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNP 566
Cdd:cd07927  77 PCKEKIIGNTKVLEIPLEPKNNMTATIDCAGILKLRNADIELRKGETDIKKKNTRARLVFRVHIPEKDGRIVSLQTASNP 156

                ....*
gi 27886541 567 IECSQ 571
Cdd:cd07927 157 IECSQ 161
RHD-n_TonEBP cd07882
N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding ...
409-571 1.43e-59

N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.


Pssm-ID: 143642  Cd Length: 161  Bit Score: 200.43  E-value: 1.43e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 409 ELRIEVQPKPHHRAHYETEGSRGAVKAPTG-GHPVVQLHGYmeNKPLGLQIFIGTADERIlKPHAFYQVHRITGKTvTTT 487
Cdd:cd07882   2 ELKILVQPETQHRARYLTEGSRGSVKDRSQqGFPTVKLEGY--NKPVVLQVFVGTDSGRV-KPHGFYQACKVTGRN-TTP 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 488 SYEKIVGNTKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETDIGRKNTRVRLVFRVHIPESSGRIVSLQTASNPI 567
Cdd:cd07882  78 CEEVDVEGTTVIEVPLDPTNNMTISVDCVGILKLRNADVEARIGIARSKKKSTRVRLVFRVIIPRKDGSTLTLQTVSNPI 157

                ....
gi 27886541 568 ECSQ 571
Cdd:cd07882 158 LCTQ 161
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
577-677 1.20e-54

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 184.23  E-value: 1.20e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 577 LPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKTTDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKV 656
Cdd:cd01178   1 LPEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGQDGEAQWEAEATIDKEKSHQNHLVVEVPPYHNKHVAAPVQV 80
                        90       100
                ....*....|....*....|.
gi 27886541 657 NFYVINGKRKRSQPQHFTYHP 677
Cdd:cd01178  81 QFYVVNGKRKRSQPQTFTYTP 101
RHD-n cd07827
N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology ...
408-571 5.54e-41

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).


Pssm-ID: 143640  Cd Length: 174  Bit Score: 148.28  E-value: 5.54e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 408 YELRIEVQPKPH-HRAHYETEG-SRGAVKAP-----TGGHPVVQLHGYMEnkPLGLQIFIGTADERiLKPHAfyqvHRIT 480
Cdd:cd07827   1 PYLEITEQPKQRgHRFRYECEGrSAGSIPGEnstadRKTFPTVKLRNYNG--PAKIVVSLVTKDDP-PKPHP----HQLV 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 481 GKTvtttsYEKIvgntKVLEIPLEPKNNMRATIDCAGILKLRNADIELRKGETD-----------------IGRKNTRVR 543
Cdd:cd07827  74 GKT-----DCRD----GVCEVRLGPKNNMTASFNNLGIQCVRKKDVEEALGQRIqlgidpfmvhkgpegnaSDIDLNRVR 144
                       170       180       190
                ....*....|....*....|....*....|
gi 27886541 544 LVFRVHIPESSG-RIVSL-QTASNPIECSQ 571
Cdd:cd07827 145 LCFQAFIEDSDGgFTLPLpPVLSNPIYDKK 174
IPT_TF cd00602
IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated ...
578-677 9.23e-34

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.


Pssm-ID: 238336  Cd Length: 101  Bit Score: 125.09  E-value: 9.23e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 578 PMVERQDTDSCLVYGGQQMILTGQNFTSE-SKVVFTEKTtDGQQIWEMEATVDKDKSQPNMLFVEIPEYRNKHIRTPVKV 656
Cdd:cd00602   1 LPICRVSSLSGSVNGGDEVFLLCDKVNKPdIKVWFGEKG-PGETVWEAEAMFRQEDVRQVAIVFKTPPYHNKWITRPVQV 79
                        90       100
                ....*....|....*....|..
gi 27886541 657 NFYVING-KRKRSQPQHFTYHP 677
Cdd:cd00602  80 PIQLVRPdDRKRSEPLTFTYTP 101
RHD_DNA_bind pfam00554
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ...
410-570 4.14e-31

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.


Pssm-ID: 425749  Cd Length: 169  Bit Score: 120.10  E-value: 4.14e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   410 LRIEVQPKPH-HRAHYETEG-SRGAVKAP-----TGGHPVVQLHGYMEnkPLGLQIFIGTADERiLKPHAfyqvHRITGK 482
Cdd:pfam00554   1 LEIVEQPKQRgMRFRYKCEGrSAGSIPGEsstrsKKTFPTVQICNYDG--PAVIRVSLVTKDEP-HRPHP----HSLVGK 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   483 TVtttsyekivgNTKVLEIPLEPKNnMRATIDCAGILKLRNADIELRKGE---TDIGRKN--------------TRVRLV 545
Cdd:pfam00554  74 DC----------KDGVCEVELGPED-MVASFQNLGIQCVKKKDVEEALKErieLNIDPFNvgfealrqikdmdlNVVRLC 142
                         170       180
                  ....*....|....*....|....*..
gi 27886541   546 FRVHIPESSGRIV--SLQTASNPIECS 570
Cdd:pfam00554 143 FQAFLPDTRGNFTtpLPPVVSNPIYDK 169
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
579-677 2.05e-30

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 465045  Cd Length: 102  Bit Score: 115.35  E-value: 2.05e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   579 MVERQDTDSCLVYGGQQMILTGQNFTSE-SKVVFTEKtTDGQQIWEMEATVDKDKSQPNM-LFVEIPEYRNKHIRTPVKV 656
Cdd:pfam16179   1 KICRLSLCSGSVTGGEEIILLCEKVLKDdIKVRFYEE-DDGQEVWEAEGDFSKTDVHRQVaIVFKTPPYRDPDITEPVTV 79
                          90       100
                  ....*....|....*....|..
gi 27886541   657 NFYVINGKRK-RSQPQHFTYHP 677
Cdd:pfam16179  80 NIQLRRPSDKaTSEPQPFTYLP 101
IPT smart00429
ig-like, plexins, transcription factors;
577-676 3.24e-14

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 68.99  E-value: 3.24e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541    577 LPMVERQDTDSCLVYGGQQMILTGQNFTSESKVVFTEKttdgqqIWEMEATVDKDKSqpNMLFVEIPEYRNKHIRTPVKv 656
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVG------VGEAPCTFSPSSS--TAIVCKTPPYHNIPGSVPVR- 71
                           90       100
                   ....*....|....*....|
gi 27886541    657 NFYVINGKRkRSQPQHFTYH 676
Cdd:smart00429  72 TVGLRNGGV-PSSPQPFTYV 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
578-677 5.98e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 50.92  E-value: 5.98e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541 578 PMVERQDTDSCLVYGGQQMILTGQNFTSES--KVVFTEkttdgqqiwemEATVDKDKSQPNMLFVEIPEYRNKHirtPVK 655
Cdd:cd00102   1 PVITSISPSSGPVSGGTEVTITGSNFGSGSnlRVTFGG-----------GVPCSVLSVSSTAIVCTTPPYANPG---PGP 66
                        90       100
                ....*....|....*....|...
gi 27886541 656 VNFYVIN-GKRKRSQPQHFTYHP 677
Cdd:cd00102  67 VEVTVDRgNGGITSSPLTFTYVP 89
PHA03247 PHA03247
large tegument protein UL36; Provisional
4-442 5.72e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.16  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541     4 PERQPQPDGGDAPGHEPGGSPQDeldfsilfdyeyLNPNEEEPNAHKVASPPSGPAYPDDVLDYGlkpySPLASLSGEPP 83
Cdd:PHA03247 2589 PDAPPQSARPRAPVDDRGDPRGP------------APPSPLPPDTHAPDPPPPSPSPAANEPDPH----PPPTVPPPERP 2652
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541    84 GRFGEPDRVG-PQKFLSAAKPAGASglSPRIEITPShELIQAVGPLRMrdagllVEQPPLAGVAASPRFTLPVPGFegyr 162
Cdd:PHA03247 2653 RDDPAPGRVSrPRRARRLGRAAQAS--SPPQRPRRR-AARPTVGSLTS------LADPPPPPPTPEPAPHALVSAT---- 2719
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   163 ePLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLC-PQFQNIPAHYSPRTSPIMSPRTSLaedsclgrhspvPRP 241
Cdd:PHA03247 2720 -PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPArPPTTAGPPAPAPPAAPAAGPPRRL------------TRP 2786
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   242 ASRSSSPGAKR----RHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMDALnslatdSPCG 317
Cdd:PHA03247 2787 AVASLSESRESlpspWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSV------APGG 2860
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   318 iPPKMWKTSPDPSPVSAAPSKAGLPRHIYPAVEflgpceqgerrnSAPESILLVPPTWPKPLVPAIPICSIPV-TASLPP 396
Cdd:PHA03247 2861 -DVRRRPPSRSPAAKPAAPARPPVRRLARPAVS------------RSTESFALPPDQPERPPQPQAPPPPQPQpQPPPPP 2927
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*.
gi 27886541   397 LEWPLSSQSGsyelRIEVQPKPHHRAHYETEGSrGAVKAPTGGHPV 442
Cdd:PHA03247 2928 QPQPPPPPPP----RPQPPLAPTTDPAGAGEPS-GAVPQPWLGALV 2968
PHA03247 PHA03247
large tegument protein UL36; Provisional
4-407 6.73e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.31  E-value: 6.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541     4 PERQPQPDGGDAPGHEPGGSPQDELDFSILFDYEYLNPN--EEEPNAHKVASPPSGP---AYPDDV---LDYGLKPYSPL 75
Cdd:PHA03247 2627 PPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRraRRLGRAAQASSPPQRPrrrAARPTVgslTSLADPPPPPP 2706
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541    76 ASLSGEPPGRFGEPDRVGPQKFLSAAKPAGASGLSPRIEITPSHELIQAVGPLRMRDAGLLVEQPPLAGVAASPRFTLPV 155
Cdd:PHA03247 2707 TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRP 2786
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   156 PGFEGYREPLCLSPASSGSSASFISDTFSPYTSPCVSPNNGGPDDLCPQfQNIPAHYSPRTSPIMSPRTSLAEDSCLGRH 235
Cdd:PHA03247 2787 AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQ-PTAPPPPPGPPPPSLPLGGSVAPGGDVRRR 2865
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   236 SPV----------PRPASRSSSPGAKRRHSCAEALVALPPGASPQRSRSPSPQPSSHVAPQDHGSPAGYPPVAGSAVIMD 305
Cdd:PHA03247 2866 PPSrspaakpaapARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAP 2945
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 27886541   306 ALNSLATDSPCGIPPKMWKTSPDPSPVSAAPSKAGLPRhiyPAVEFLGPCEQGERRNSAPESillvpPTWPKPLvpAIPI 385
Cdd:PHA03247 2946 TTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPA---PSREAPASSTPPLTGHSLSRV-----SSWASSL--ALHE 3015
                         410       420
                  ....*....|....*....|..
gi 27886541   386 CSIPVTASLPPLEWPLSSQSGS 407
Cdd:PHA03247 3016 ETDPPPVSLKQTLWPPDDTEDS 3037
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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