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Conserved domains on  [gi|255522823|ref|NP_775278|]
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TBC1 domain family member 24 isoform b [Mus musculus]

Protein Classification

RabGAP-TBC and TLDc domain-containing protein (domain architecture ID 10456646)

protein containing domains RabGAP-TBC, DUF499, and TLDc

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
336-550 1.02e-56

domain in TBC and LysM domain containing proteins;


:

Pssm-ID: 214733  Cd Length: 165  Bit Score: 187.53  E-value: 1.02e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823   336 SEIVSVKEMRDIWSWIPERFALCQPLLLFSSLQHGYSLSRFYFQCEG-HEPTLLLIKTTQKEVCGAYLSTDWSERTKfgg 414
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGyRPPTLLIIKDTDGEVFGAYASQAWRVSDH--- 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823   415 klgFFGTGECFVFRLQPEVQRYEWVVIKHpeltkatslksseaagssslishcssdpadrlspflaarhfnlpskteSMF 494
Cdd:smart00584  78 ---FYGTGESFLFQLNPKFVVYDWTGKNK------------------------------------------------YYY 106
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 255522823   495 MAGGNDCLIIGGGGGQ-ALYVDGDLNRGRTGHCDTFNNQPLCS--ENFLIAAVEAWGFQ 550
Cdd:smart00584 107 INGTPDSLPIGGGGGGfGLWIDEDLNHGSSSHCKTFGNPPLSTkqEDFLILDIEVWGFG 165
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
48-253 4.70e-26

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


:

Pssm-ID: 366170  Cd Length: 180  Bit Score: 104.64  E-value: 4.70e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823   48 HTLRGKVYQRLIRDIpcrtvtpdasvYSDIvgkivgkhsSSSLPLPEFVDNTQvptyclntrGEGAVRKILLCIANQFPD 127
Cdd:pfam00566   1 DSLRGRVWPLLLSQI-----------RKDV---------PRTFPHSFFFDNGP---------GQNSLRRILKAYSIYNPD 51
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823  128 ISFCPALPAVVALLLHYSIDEAECFEKACRILSCNDPtKKLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQ 207
Cdd:pfam00566  52 VGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENYLL-RDFYTPDFPGLKRDFYVFEELLKKYDPKLYKHLKELGLDPDL 130
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 255522823  208 VYSDWQRWLF-GELPLNYFARVFDVFLvEGYKV-LYRVALAILKFFHK 253
Cdd:pfam00566 131 FATKWFLTLFaREFPLSTVLRIWDFLL-EGEKFvLFRVALAILKRFRE 177
DUF499 super family cl19819
Protein of unknown function (DUF499); Family of uncharacterized hypothetical prokaryotic ...
265-352 1.42e-03

Protein of unknown function (DUF499); Family of uncharacterized hypothetical prokaryotic proteins.


The actual alignment was detected with superfamily member COG1483:

Pssm-ID: 388639  Cd Length: 774  Bit Score: 41.29  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823 265 VKQDIRMFVKDIAKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALRQ--KGITVKQKRQFVHLAVHAENFHSEIVSVk 342
Cdd:COG1483  254 VVRVNFHPSKQILKPVGIEAELVEILLKRIFEYVDEEEKREALERASREfsNLERRGEEAPAQESLRATYPFHPEYPEV- 332
                         90
                 ....*....|
gi 255522823 343 eMRDIWSWIP 352
Cdd:COG1483  333 -LRDLTERIS 341
 
Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
336-550 1.02e-56

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 187.53  E-value: 1.02e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823   336 SEIVSVKEMRDIWSWIPERFALCQPLLLFSSLQHGYSLSRFYFQCEG-HEPTLLLIKTTQKEVCGAYLSTDWSERTKfgg 414
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGyRPPTLLIIKDTDGEVFGAYASQAWRVSDH--- 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823   415 klgFFGTGECFVFRLQPEVQRYEWVVIKHpeltkatslksseaagssslishcssdpadrlspflaarhfnlpskteSMF 494
Cdd:smart00584  78 ---FYGTGESFLFQLNPKFVVYDWTGKNK------------------------------------------------YYY 106
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 255522823   495 MAGGNDCLIIGGGGGQ-ALYVDGDLNRGRTGHCDTFNNQPLCS--ENFLIAAVEAWGFQ 550
Cdd:smart00584 107 INGTPDSLPIGGGGGGfGLWIDEDLNHGSSSHCKTFGNPPLSTkqEDFLILDIEVWGFG 165
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
48-253 4.70e-26

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 366170  Cd Length: 180  Bit Score: 104.64  E-value: 4.70e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823   48 HTLRGKVYQRLIRDIpcrtvtpdasvYSDIvgkivgkhsSSSLPLPEFVDNTQvptyclntrGEGAVRKILLCIANQFPD 127
Cdd:pfam00566   1 DSLRGRVWPLLLSQI-----------RKDV---------PRTFPHSFFFDNGP---------GQNSLRRILKAYSIYNPD 51
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823  128 ISFCPALPAVVALLLHYSIDEAECFEKACRILSCNDPtKKLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQ 207
Cdd:pfam00566  52 VGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENYLL-RDFYTPDFPGLKRDFYVFEELLKKYDPKLYKHLKELGLDPDL 130
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 255522823  208 VYSDWQRWLF-GELPLNYFARVFDVFLvEGYKV-LYRVALAILKFFHK 253
Cdd:pfam00566 131 FATKWFLTLFaREFPLSTVLRIWDFLL-EGEKFvLFRVALAILKRFRE 177
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
364-549 1.68e-25

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 400081  Cd Length: 136  Bit Score: 101.92  E-value: 1.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823  364 FSSLQHGYSLSRFYFQCEGHEPTLLLIKTTQKEVCGAYLSTDWSERTKfggklGFFGTGECFVFRLQPEVQRYEWvvikh 443
Cdd:pfam07534   1 YSTSRDGRSYQTFYEKIDNKGPTLLIIKDNDGYIFGAFASQPWKVSGK-----KFYGDGSSFLFSLSPQFDPYKW----- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823  444 peltkatslksseaagssslishcssdpadrlspflaarhfnlpSKTESMFMAGGNDCLIIGGGGGQ-ALYVDGDLNRGR 522
Cdd:pfam07534  71 --------------------------------------------TGKNNAYFNCTSDGLGFGGGQPKfDLWIDSDLEFGY 106
                         170       180       190
                  ....*....|....*....|....*....|
gi 255522823  523 TGHCDTFNNQPLCS---ENFLIAAVEAWGF 549
Cdd:pfam07534 107 SRHCETFGNGQLSGsgqERFKIDDVEVWGL 136
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
115-254 2.83e-13

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540  Cd Length: 216  Bit Score: 68.87  E-value: 2.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823   115 RKILLCIANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRIlsCNDPTKKLIDQSFLAFESSCMTFGDLVNKYCQAA 194
Cdd:smart00164  76 RRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKL--MERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDL 153
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 255522823   195 HKLMVAVSEDVLQVYSDWQRWLFG-ELPLNYFARVFDVFLVEGYKVLYRVALAILKFFHKV 254
Cdd:smart00164 154 YKHLKDLGITPSLYALRWFLTLFArELPLEIVLRIWDVLFAEGSDFLFRVALALLKLHRDV 214
OXR1 COG5142
Oxidation resistance protein [DNA replication, recombination, and repair];
351-547 3.06e-07

Oxidation resistance protein [DNA replication, recombination, and repair];


Pssm-ID: 227471  Cd Length: 212  Bit Score: 51.05  E-value: 3.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823 351 IPERFALCQPL-LLFSSLQHGYSLSRFYFQCEGHE------PTLLLIKTTQKEVCGAYLStdwserTKFGGKLGFFGTGE 423
Cdd:COG5142   49 LPDRYKYSTSWrLLYSLFENGFSLRTFYESFGENEwpfrrvGFVLACRDKDGDLFGAFFE------DRIRPARHYYGRDE 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823 424 CFVFRLQpevqryewvviKHPeltkATSLKSSEAAGSsslishcssdpadrlsPFLAARHFNLPSKTEsmFMAGGndcli 503
Cdd:COG5142  123 MFLWKAA-----------RRP----ADRLADKEVAVY----------------PISGGKGFGIYCTPD--FLAFG----- 164
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 255522823 504 iGGGGGQALYVDGDLNRGRTGHCDTFNNQPLCSEN--FLIAAVEAW 547
Cdd:COG5142  165 -CGGGRYGLLIDKSLLDGESHPVETFGNCLLSSKGhfFRIVYLELW 209
COG5210 COG5210
GTPase-activating protein [General function prediction only];
114-325 6.11e-05

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 45.56  E-value: 6.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823 114 VRKILLCIANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRILsCNDPTKKLIDQSFLAFESSCMTFGDLVNKYC-- 191
Cdd:COG5210  285 LRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLL-KNYGLPGYFLKNLSGLHRDLKVLDDLVEELDpe 363
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823 192 QAAHKLMVAVSEDVLQVYsdWQRWLF-GELPLNYFARVFDVFLVEGYKVLYRVALAILKffhKVRAGQ-PLESDNVKQDI 269
Cdd:COG5210  364 LYEHLLREGVVLLMFAFR--WFLTLFvREFPLEYALRIWDCLFLEGSSMLFQLALAILK---LLRDKLlKLDSDELLDLL 438
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 255522823 270 rmFVKDIAKtvSPEKLLEKAFAIRLFSRKEIQLLQManekALRQKGITVKQKRQFV 325
Cdd:COG5210  439 --LKQLFLH--SGKEAWSSILKFRHGTDRDILLFIE----DLLKKDITPTRYRSEL 486
COG1483 COG1483
Predicted ATPase, AAA+ superfamily [General function prediction only];
265-352 1.42e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 224400  Cd Length: 774  Bit Score: 41.29  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823 265 VKQDIRMFVKDIAKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALRQ--KGITVKQKRQFVHLAVHAENFHSEIVSVk 342
Cdd:COG1483  254 VVRVNFHPSKQILKPVGIEAELVEILLKRIFEYVDEEEKREALERASREfsNLERRGEEAPAQESLRATYPFHPEYPEV- 332
                         90
                 ....*....|
gi 255522823 343 eMRDIWSWIP 352
Cdd:COG1483  333 -LRDLTERIS 341
 
Name Accession Description Interval E-value
TLDc smart00584
domain in TBC and LysM domain containing proteins;
336-550 1.02e-56

domain in TBC and LysM domain containing proteins;


Pssm-ID: 214733  Cd Length: 165  Bit Score: 187.53  E-value: 1.02e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823   336 SEIVSVKEMRDIWSWIPERFALCQPLLLFSSLQHGYSLSRFYFQCEG-HEPTLLLIKTTQKEVCGAYLSTDWSERTKfgg 414
Cdd:smart00584   1 SSILSEEILALINSHLPTRAEGYPWTLLYSSSQHGYSLNTLYRKVEGyRPPTLLIIKDTDGEVFGAYASQAWRVSDH--- 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823   415 klgFFGTGECFVFRLQPEVQRYEWVVIKHpeltkatslksseaagssslishcssdpadrlspflaarhfnlpskteSMF 494
Cdd:smart00584  78 ---FYGTGESFLFQLNPKFVVYDWTGKNK------------------------------------------------YYY 106
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 255522823   495 MAGGNDCLIIGGGGGQ-ALYVDGDLNRGRTGHCDTFNNQPLCS--ENFLIAAVEAWGFQ 550
Cdd:smart00584 107 INGTPDSLPIGGGGGGfGLWIDEDLNHGSSSHCKTFGNPPLSTkqEDFLILDIEVWGFG 165
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
48-253 4.70e-26

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 366170  Cd Length: 180  Bit Score: 104.64  E-value: 4.70e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823   48 HTLRGKVYQRLIRDIpcrtvtpdasvYSDIvgkivgkhsSSSLPLPEFVDNTQvptyclntrGEGAVRKILLCIANQFPD 127
Cdd:pfam00566   1 DSLRGRVWPLLLSQI-----------RKDV---------PRTFPHSFFFDNGP---------GQNSLRRILKAYSIYNPD 51
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823  128 ISFCPALPAVVALLLHYSIDEAECFEKACRILSCNDPtKKLIDQSFLAFESSCMTFGDLVNKYCQAAHKLMVAVSEDVLQ 207
Cdd:pfam00566  52 VGYCQGMNFIAAPLLLVYLDEEDAFWCFVSLLENYLL-RDFYTPDFPGLKRDFYVFEELLKKYDPKLYKHLKELGLDPDL 130
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 255522823  208 VYSDWQRWLF-GELPLNYFARVFDVFLvEGYKV-LYRVALAILKFFHK 253
Cdd:pfam00566 131 FATKWFLTLFaREFPLSTVLRIWDFLL-EGEKFvLFRVALAILKRFRE 177
TLD pfam07534
TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It ...
364-549 1.68e-25

TLD; This domain is predicted to be an enzyme and is often found associated with pfam01476. It's structure consists of a beta-sandwich surrounded by two helices and two one-turn helices.


Pssm-ID: 400081  Cd Length: 136  Bit Score: 101.92  E-value: 1.68e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823  364 FSSLQHGYSLSRFYFQCEGHEPTLLLIKTTQKEVCGAYLSTDWSERTKfggklGFFGTGECFVFRLQPEVQRYEWvvikh 443
Cdd:pfam07534   1 YSTSRDGRSYQTFYEKIDNKGPTLLIIKDNDGYIFGAFASQPWKVSGK-----KFYGDGSSFLFSLSPQFDPYKW----- 70
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823  444 peltkatslksseaagssslishcssdpadrlspflaarhfnlpSKTESMFMAGGNDCLIIGGGGGQ-ALYVDGDLNRGR 522
Cdd:pfam07534  71 --------------------------------------------TGKNNAYFNCTSDGLGFGGGQPKfDLWIDSDLEFGY 106
                         170       180       190
                  ....*....|....*....|....*....|
gi 255522823  523 TGHCDTFNNQPLCS---ENFLIAAVEAWGF 549
Cdd:pfam07534 107 SRHCETFGNGQLSGsgqERFKIDDVEVWGL 136
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
115-254 2.83e-13

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540  Cd Length: 216  Bit Score: 68.87  E-value: 2.83e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823   115 RKILLCIANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRIlsCNDPTKKLIDQSFLAFESSCMTFGDLVNKYCQAA 194
Cdd:smart00164  76 RRVLKAYALYNPEVGYCQGMNFLAAPLLLVMEDEEDAFWCLVKL--MERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDL 153
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 255522823   195 HKLMVAVSEDVLQVYSDWQRWLFG-ELPLNYFARVFDVFLVEGYKVLYRVALAILKFFHKV 254
Cdd:smart00164 154 YKHLKDLGITPSLYALRWFLTLFArELPLEIVLRIWDVLFAEGSDFLFRVALALLKLHRDV 214
OXR1 COG5142
Oxidation resistance protein [DNA replication, recombination, and repair];
351-547 3.06e-07

Oxidation resistance protein [DNA replication, recombination, and repair];


Pssm-ID: 227471  Cd Length: 212  Bit Score: 51.05  E-value: 3.06e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823 351 IPERFALCQPL-LLFSSLQHGYSLSRFYFQCEGHE------PTLLLIKTTQKEVCGAYLStdwserTKFGGKLGFFGTGE 423
Cdd:COG5142   49 LPDRYKYSTSWrLLYSLFENGFSLRTFYESFGENEwpfrrvGFVLACRDKDGDLFGAFFE------DRIRPARHYYGRDE 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823 424 CFVFRLQpevqryewvviKHPeltkATSLKSSEAAGSsslishcssdpadrlsPFLAARHFNLPSKTEsmFMAGGndcli 503
Cdd:COG5142  123 MFLWKAA-----------RRP----ADRLADKEVAVY----------------PISGGKGFGIYCTPD--FLAFG----- 164
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 255522823 504 iGGGGGQALYVDGDLNRGRTGHCDTFNNQPLCSEN--FLIAAVEAW 547
Cdd:COG5142  165 -CGGGRYGLLIDKSLLDGESHPVETFGNCLLSSKGhfFRIVYLELW 209
COG5210 COG5210
GTPase-activating protein [General function prediction only];
114-325 6.11e-05

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 45.56  E-value: 6.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823 114 VRKILLCIANQFPDISFCPALPAVVALLLHYSIDEAECFEKACRILsCNDPTKKLIDQSFLAFESSCMTFGDLVNKYC-- 191
Cdd:COG5210  285 LRRVLKAYSLYNPEVGYVQGMNFLAAPLLLVLESEEQAFWCLVKLL-KNYGLPGYFLKNLSGLHRDLKVLDDLVEELDpe 363
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823 192 QAAHKLMVAVSEDVLQVYsdWQRWLF-GELPLNYFARVFDVFLVEGYKVLYRVALAILKffhKVRAGQ-PLESDNVKQDI 269
Cdd:COG5210  364 LYEHLLREGVVLLMFAFR--WFLTLFvREFPLEYALRIWDCLFLEGSSMLFQLALAILK---LLRDKLlKLDSDELLDLL 438
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 255522823 270 rmFVKDIAKtvSPEKLLEKAFAIRLFSRKEIQLLQManekALRQKGITVKQKRQFV 325
Cdd:COG5210  439 --LKQLFLH--SGKEAWSSILKFRHGTDRDILLFIE----DLLKKDITPTRYRSEL 486
COG1483 COG1483
Predicted ATPase, AAA+ superfamily [General function prediction only];
265-352 1.42e-03

Predicted ATPase, AAA+ superfamily [General function prediction only];


Pssm-ID: 224400  Cd Length: 774  Bit Score: 41.29  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 255522823 265 VKQDIRMFVKDIAKTVSPEKLLEKAFAIRLFSRKEIQLLQMANEKALRQ--KGITVKQKRQFVHLAVHAENFHSEIVSVk 342
Cdd:COG1483  254 VVRVNFHPSKQILKPVGIEAELVEILLKRIFEYVDEEEKREALERASREfsNLERRGEEAPAQESLRATYPFHPEYPEV- 332
                         90
                 ....*....|
gi 255522823 343 eMRDIWSWIP 352
Cdd:COG1483  333 -LRDLTERIS 341
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.19
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
  • Marchler-Bauer A et al. (2015), "CDD: NCBI's conserved domain database.", Nucleic Acids Res.43(D)222-6.
  • Marchler-Bauer A et al. (2011), "CDD: a Conserved Domain Database for the functional annotation of proteins.", Nucleic Acids Res.39(D)225-9.
  • Marchler-Bauer A, Bryant SH (2004), "CD-Search: protein domain annotations on the fly.", Nucleic Acids Res.32(W)327-331.
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