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Conserved domains on  [gi|31982147|ref|NP_775547|]
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GDH/6PGL endoplasmic bifunctional protein isoform 1 precursor [Mus musculus]

Protein Classification

PTZ00309 and 6PGL domain-containing protein( domain architecture ID 13232975)

PTZ00309 and 6PGL domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTZ00309 super family cl29403
glucose-6-phosphate 1-dehydrogenase; Provisional
 31-510 7.28e-97

glucose-6-phosphate 1-dehydrogenase; Provisional


The actual alignment was detected with superfamily member PTZ00309:

Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 311.68  E-value: 7.28e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   31 VSIILLGATGDLAKKYLWQGLFQLYLDeaGK-GHSFSFHGAALTA-PQQGQKLMDKVLESLSCPKDLvpsrcDELKGQFL 108
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYCE--GLlPSEVNIVGYARSKmSDVERWKKETLARFFKRLDDR-----ECHLEQFL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  109 QLSQYR--QLKTVEDYQTLNKDIETQVQQDGLWEAG--RIFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHD 184
Cdd:PTZ00309 128 KHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFGRD 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  185 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGV 264
Cdd:PTZ00309 207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGI 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  265 IRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAILGQYQAYS-GQVRRELQK---PDGfqSLTP 340
Cdd:PTZ00309 286 IRDVMQNHLLQILALLAMEKPVSLSAE-DIRDEKVKVLKCIEPIKMEECVLGQYTASAdGSIPGYLEDegvPKD--STTP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  341 TFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNrayctqserhwVPEqsrclpqqIIFYighGELGHPAILVS 420
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----------VDE--------FRPS---GDDTQRNELVI 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  421 RnlFKPSlPTQKWKEVQDQPGLrlfGRPLS------DYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTP 494
Cdd:PTZ00309 421 R--AQPS-EAMYLKITAKVPGL---SNDLHqteldlTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTP 494

                        490
                 ....*....|....*...
gi 31982147  495 LLDSL-AFEV-PRPYPGG 510
Cdd:PTZ00309 495 LLHQIdRGEVkPEPYPFG 512
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 562-797 3.45e-91

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


:

Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 285.81  E-value: 3.45e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   562 ITAWPEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGhySFPWAHTHLWLVDERCVPLSDPDSNFQG 641
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   642 LQAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVAN---SSFDLVLLGMGTDGHTASLFPQSPTGLDG 718
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTEL-----SDIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   719 DQLV-VLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPlSGQLVWYMDYEAFLG 797
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLH-SGKTLWLLDYAAARK 232
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 31-510 7.28e-97

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 311.68  E-value: 7.28e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   31 VSIILLGATGDLAKKYLWQGLFQLYLDeaGK-GHSFSFHGAALTA-PQQGQKLMDKVLESLSCPKDLvpsrcDELKGQFL 108
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYCE--GLlPSEVNIVGYARSKmSDVERWKKETLARFFKRLDDR-----ECHLEQFL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  109 QLSQYR--QLKTVEDYQTLNKDIETQVQQDGLWEAG--RIFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHD 184
Cdd:PTZ00309 128 KHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFGRD 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  185 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGV 264
Cdd:PTZ00309 207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGI 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  265 IRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAILGQYQAYS-GQVRRELQK---PDGfqSLTP 340
Cdd:PTZ00309 286 IRDVMQNHLLQILALLAMEKPVSLSAE-DIRDEKVKVLKCIEPIKMEECVLGQYTASAdGSIPGYLEDegvPKD--STTP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  341 TFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNrayctqserhwVPEqsrclpqqIIFYighGELGHPAILVS 420
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----------VDE--------FRPS---GDDTQRNELVI 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  421 RnlFKPSlPTQKWKEVQDQPGLrlfGRPLS------DYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTP 494
Cdd:PTZ00309 421 R--AQPS-EAMYLKITAKVPGL---SNDLHqteldlTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTP 494

                        490
                 ....*....|....*...
gi 31982147  495 LLDSL-AFEV-PRPYPGG 510
Cdd:PTZ00309 495 LLHQIdRGEVkPEPYPFG 512
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 562-797 3.45e-91

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 285.81  E-value: 3.45e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   562 ITAWPEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGhySFPWAHTHLWLVDERCVPLSDPDSNFQG 641
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   642 LQAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVAN---SSFDLVLLGMGTDGHTASLFPQSPTGLDG 718
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTEL-----SDIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   719 DQLV-VLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPlSGQLVWYMDYEAFLG 797
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLH-SGKTLWLLDYAAARK 232
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
564-788 1.04e-83

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 266.03  E-value: 1.04e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   564 AWPEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGHYSFPWAHTHLWLVDERCVPLSDPDSNFQGLQ 643
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   644 AHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVANSS---FDLVLLGMGTDGHTASLFPQSPTGLDGDQ 720
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   721 LVV-LTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV-GHEPKKWPISGVVPLSGQLVW 788
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 33-510 3.84e-83

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 273.81  E-value: 3.84e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147    33 IILLGATGDLAKKYLWQGLFQLY----LDEagkghSFSFHGAA---LTAPQQGQKLMDKVLESlscPKDLVPSRCDELKG 105
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFrnglLPP-----DFRIVGVArrdWSVEEFRKVVREAIIKF---ETDEIDEQWDEFAQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   106 QFLQLSQyrQLKTVEDYQTLNKDIEtQVQQDGLWEAGRIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 185
Cdd:TIGR00871  77 RLSYVSG--DVDDDESYDSLAELLE-QLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   186 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVI 265
Cdd:TIGR00871 154 ASAQELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQ-IFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGAL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   266 RDTLQNHLTEILTLVAMELPlNISSSAAVLQHKLWAFQALRGLQK--SSAILGQYQAysGQVRRElQKP-----DGF--Q 336
Cdd:TIGR00871 233 RDMVQNHLLQLLALVAMEPP-VSFDADSIRDEKVKVLKALRPIDPddNNTVRGQYGA--GEIGGV-SVPgyleeEGVdkD 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   337 SLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNRAYCTQSERhwvpEQSRCLPQQIIFYIGHGElghpA 416
Cdd:TIGR00871 309 SNTETFAALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKAN----ERDANPRNALVIRIQPDE----G 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   417 ILVSRNLFKPSLpTQKWKEVQ-DQPGLRLFGRPLSdyyayrpvreqDAYSTLLSHIFHCRKESFITTENLLASWVFWTPL 495
Cdd:TIGR00871 381 VYLKFNAKKPGL-NFETRPVKlDFSYASRFGELLP-----------EAYERLLLDALLGDHTLFARDDEVEEAWRIVTPI 448

                         490
                  ....*....|....*...
gi 31982147   496 LDSLAF---EVPRPYPGG 510
Cdd:TIGR00871 449 LEAWAAnkgPSPPNYPAG 466
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 567-790 5.91e-79

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 253.25  E-value: 5.91e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 567 EELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGhYSFPWAHTHLWLVDERCVPLSDPDSNFQGLQAHL 646
Cdd:cd01400   1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 647 LQHVRVPYYNIHPMPVHLHqrlcaeEDQGAQTYASEISALVANS-SFDLVLLGMGTDGHTASLFPQSP-TGLDGDQLVVL 724
Cdd:cd01400  80 LSHVAIPAANIHPIPTELG------PEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31982147 725 TE-SPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSGQLVWYM 790
Cdd:cd01400 154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 33-380 9.89e-77

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 256.93  E-value: 9.89e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  33 IILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKVLESLscpKDLVPSRCDELK-GQFL 108
Cdd:COG0364  12 LVIFGATGDLARRKLLPALYNLYRD----GLlpeGFRIIGVARR-DWSDEEFREEVREAL---EEFSRKPFDEEVwERFL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 109 QLSQYRQL--KTVEDYQTLNKDIEtqvQQDGLWEAG-RIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 185
Cdd:COG0364  84 ERLHYVSGdfTDPEGYERLKELLE---ELDEERTPGnRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 186 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVI 265
Cdd:COG0364 161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANA-LFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 266 RDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKS----SAILGQYQAysGQVRRELQKP----DGF-- 335
Cdd:COG0364 240 RDMVQNHLLQLLCLVAMEPPASLDAD-AIRDEKVKVLRALRPITPEdvaeNTVRGQYTA--GWIGGEPVPGyreePGVap 316

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 31982147 336 QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKN 380
Cdd:COG0364 317 DSTTETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKP 361
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
233-510 4.37e-62

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 210.76  E-value: 4.37e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   233 LWNRHHVERVEIILKETIDAEGRASFYEEYGVIRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSS 312
Cdd:pfam02781  13 LWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAE-DIRDEKVKVLRSLRPITPED 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   313 ----AILGQYQAysGQVRRELQK---------PDgfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFK 379
Cdd:pfam02781  92 vednVVRGQYGA--GWIGGEPVPgyreeegvpPD---SRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRIQFK 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   380 NrayctqserhwVP-----EQSRCLPQQIIFYIGHGElghpAILVSRNLFKpslptqkwkevqdqPGLRLFGRPLS---D 451
Cdd:pfam02781 167 D-----------VPhnlfrDPGTLPPNELVIRIQPDE----GIYLKFNAKV--------------PGLGMRLRPVEldfS 217

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31982147   452 YYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLAFEVPRPYPGG 510
Cdd:pfam02781 218 YSDRFGERIPEAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAG 276
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 566-794 1.04e-55

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 191.91  E-value: 1.04e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 566 PEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGHYS--FPWAHTHLWLVDERC-VPLSDPDSNFQGL 642
Cdd:COG0363  10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKEggLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 643 QAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPTGLDGDQLV 722
Cdd:COG0363  90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 723 VLTESPFR------------PHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSgQLVW 788
Cdd:COG0363 162 TLDESTRQanarffgsipkvPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237


                ....*.
gi 31982147 789 YMDYEA 794
Cdd:COG0363 238 FLDEAA 243
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 567-794 1.64e-30

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 121.12  E-value: 1.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  567 EELISKLASDIEAAAVQAVRHFGKFHLALSGGSSpIALFQQLATGHY--SFPWAHTHLWLVDERCVPLSDPDSNFQGLQA 644
Cdd:PLN02360  20 DELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYnkTVDWAKWYIFWADERVVAKNHADSNYKLAKD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  645 HLLQHVRVPYYNIHPmpvhLHQRLCAEEdqGAQTYASEISALVANSS-----------FDLVLLGMGTDGHTASLFPQSP 713
Cdd:PLN02360  99 GLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNHP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  714 T-GLDGDQLVVLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTL-VSRVGHEP--KKWPISGVVPLSGQLVWY 789
Cdd:PLN02360 173 AlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVWF 252


                 ....*
gi 31982147  790 MDYEA 794
Cdd:PLN02360 253 LDKPA 257
 
Name Accession Description Interval E-value
PTZ00309 PTZ00309
glucose-6-phosphate 1-dehydrogenase; Provisional
 31-510 7.28e-97

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 240353 [Multi-domain]  Cd Length: 542  Bit Score: 311.68  E-value: 7.28e-97
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   31 VSIILLGATGDLAKKYLWQGLFQLYLDeaGK-GHSFSFHGAALTA-PQQGQKLMDKVLESLSCPKDLvpsrcDELKGQFL 108
Cdd:PTZ00309  55 LTIIVLGASGDLAKKKTFPALFQLYCE--GLlPSEVNIVGYARSKmSDVERWKKETLARFFKRLDDR-----ECHLEQFL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  109 QLSQYR--QLKTVEDYQTLNKDIETQVQQDGLWEAG--RIFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHD 184
Cdd:PTZ00309 128 KHISYIsgSYDEDEDFKRLNKLIERMEEAFQGPEKGgnRLFYLALPPSVFASVCEGIHRGCMSKNG-WVRVIVEKPFGRD 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  185 HLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGV 264
Cdd:PTZ00309 207 LESSEELSNQLEPLFDESQLYRIDHYLGKEMVQNLIVLRFANR-VFEPLWNRNNIACVQITFKEDIGTEGRGGYFDSYGI 285

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  265 IRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAILGQYQAYS-GQVRRELQK---PDGfqSLTP 340
Cdd:PTZ00309 286 IRDVMQNHLLQILALLAMEKPVSLSAE-DIRDEKVKVLKCIEPIKMEECVLGQYTASAdGSIPGYLEDegvPKD--STTP 362

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  341 TFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNrayctqserhwVPEqsrclpqqIIFYighGELGHPAILVS 420
Cdd:PTZ00309 363 TFAAAVLHINNDRWEGVPFILEAGKALEERYVEIRIQFKG-----------VDE--------FRPS---GDDTQRNELVI 420

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  421 RnlFKPSlPTQKWKEVQDQPGLrlfGRPLS------DYYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTP 494
Cdd:PTZ00309 421 R--AQPS-EAMYLKITAKVPGL---SNDLHqteldlTYKTRYNVRLPDAYERLILDALLGDSTNFVRKDELDVAWRIFTP 494

                        490
                 ....*....|....*...
gi 31982147  495 LLDSL-AFEV-PRPYPGG 510
Cdd:PTZ00309 495 LLHQIdRGEVkPEPYPFG 512
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 562-797 3.45e-91

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 285.81  E-value: 3.45e-91
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   562 ITAWPEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGhySFPWAHTHLWLVDERCVPLSDPDSNFQG 641
Cdd:TIGR01198   1 VFSNSAELAEALAERIATKLQTALAERGQFSLALSGGRSPIALLEALAAQ--PLDWSRIHLFLGDERYVPLDHADSNTGL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   642 LQAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVAN---SSFDLVLLGMGTDGHTASLFPQSPTGLDG 718
Cdd:TIGR01198  79 AREALLDRVAIPASNIHPMPTEL-----SDIEEAAELYEQELAAAFQPivfPVFDLLLLGMGPDGHTASLFPHTPALQET 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   719 DQLV-VLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTLVSRVGHEPKKWPISGVVPlSGQLVWYMDYEAFLG 797
Cdd:TIGR01198 154 ERLVtVLTKSPKPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAVEAEPYPLPAAGVLH-SGKTLWLLDYAAARK 232
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
564-788 1.04e-83

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 266.03  E-value: 1.04e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   564 AWPEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGHYSFPWAHTHLWLVDERCVPLSDPDSNFQGLQ 643
Cdd:pfam01182   1 PDAEALAQALAERLAEALEAALAERGRFTLALSGGSTPKPLYELLAAAPARLDWSRVHVFWGDERCVPPDDPDSNYGMAR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   644 AHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALVANSS---FDLVLLGMGTDGHTASLFPQSPTGLDGDQ 720
Cdd:pfam01182  81 EALLSHVPIPASNVHPIPASA-----ADPEEAAAAYEAELRELLPDLElpvFDLVLLGMGPDGHTASLFPGSPALEETDR 155

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   721 LVV-LTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV-GHEPKKWPISGVVPLSGQLVW 788
Cdd:pfam01182 156 LVVaVTDSPKPPPERITLTLPVLNAARRVWFLVTGAGKADA---LRRAlAGDPDPLPAALVRPGAGETVW 222
PLN02539 PLN02539
glucose-6-phosphate 1-dehydrogenase
 28-511 1.78e-83

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 178154 [Multi-domain]  Cd Length: 491  Bit Score: 274.68  E-value: 1.78e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   28 KGHVSIILLGATGDLAKKYLWQGLFQLYLDEAGKGHSFSFHGAALTaPQQGQKLMDKVLESLSCPKDlvpsRCDELKGQF 107
Cdd:PLN02539  15 TGCLSIIVLGASGDLAKKKTFPALFNLYRQGFLPPDEVHIFGYARS-KITDEELRDRIRGYLKDEKN----APAEAVSKF 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  108 LQLSQYRQ--LKTVEDYQTLNKDI-ETQVQQDGLWEAG-RIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGH 183
Cdd:PLN02539  90 LQLIKYVSgaYDSEEGFRRLDKEIsEHEISKNSAEGSSrRLFYLALPPSVYPPVCKMIKKCCMNKSGLWTRIVVEKPFGK 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  184 DHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRKALDgLWNRHHVERVEIILKETIDAEGRASFYEEYG 263
Cdd:PLN02539 170 DLESAEELSSQIGELFDESQLYRIDHYLGKELVQNLLVLRFANRFFLP-LWNRDNIANVQIVFREDFGTEGRGGYFDEYG 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  264 VIRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAILGQYQAYsgqvRRELQKPDGfqSLTPTFA 343
Cdd:PLN02539 249 IIRDIIQNHLLQVLCLVAMEKPVSLKPE-HIRDEKVKVLQSVEPIKDEEVVLGQYEGY----RDDPTVPDD--SNTPTFA 321

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  344 GVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNrayctqserhwVP-EQSRCLPQqiifyighgelghpailvSRN 422
Cdd:PLN02539 322 SVVLRINNERWEGVPFILKAGKALDSRKAEIRVQFKD-----------VPgDIFKCQKQ------------------GRN 372

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  423 LF----KPSlPTQKWKEVQDQPGL--RLFGRPLSDYYA--YRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTP 494
Cdd:PLN02539 373 EFvirlQPS-EAMYMKLTVKQPGLemSTVQSELDLSYGqrYQDVVIPEAYERLILDTIRGDQQHFVRRDELKAAWEIFTP 451

                        490
                 ....*....|....*....
gi 31982147  495 LLDSL-AFEV-PRPYPGGA 511
Cdd:PLN02539 452 LLHRIdAGKVkPIPYKQGS 470
zwf TIGR00871
glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and ...
 33-510 3.84e-83

glucose-6-phosphate 1-dehydrogenase; This enzyme (EC 1.1.1.49) acts on glucose 6-phospate and reduces NADP(+). An alternate name appearing in the literature for the human enzyme, based on a slower activity with beta-D-glucose, is glucose 1-dehydrogenase (EC 1.1.1.47), but that name more properly describes a subfamily of the short chain dehydrogenases/reductases family. This is a well-studied enzyme family, with sequences available from well over 50 species. The trusted cutoff is set above the score for the Drosophila melanogaster CG7140 gene product, a homolog of unknown function. G6PD homologs from the bacteria Aquifex aeolicus and Helicobacter pylori lack several motifs well conserved most other members, were omitted from the seed alignment, and score well below the trusted cutoff. [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273312 [Multi-domain]  Cd Length: 487  Bit Score: 273.81  E-value: 3.84e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147    33 IILLGATGDLAKKYLWQGLFQLY----LDEagkghSFSFHGAA---LTAPQQGQKLMDKVLESlscPKDLVPSRCDELKG 105
Cdd:TIGR00871   5 LVIFGASGDLARKKLFPALYRLFrnglLPP-----DFRIVGVArrdWSVEEFRKVVREAIIKF---ETDEIDEQWDEFAQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   106 QFLQLSQyrQLKTVEDYQTLNKDIEtQVQQDGLWEAGRIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 185
Cdd:TIGR00871  77 RLSYVSG--DVDDDESYDSLAELLE-QLDKTYGTEGNRLFYLATPPSLFGTIIKQLKKHGLNEQGKWSRVVVEKPFGHDL 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   186 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVI 265
Cdd:TIGR00871 154 ASAQELNKALRAVFKEDQIYRIDHYLGKETVQNLLVLRFANQ-IFEPLWNRRYIDHVQITVAESFGVEGRGGYYDKSGAL 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   266 RDTLQNHLTEILTLVAMELPlNISSSAAVLQHKLWAFQALRGLQK--SSAILGQYQAysGQVRRElQKP-----DGF--Q 336
Cdd:TIGR00871 233 RDMVQNHLLQLLALVAMEPP-VSFDADSIRDEKVKVLKALRPIDPddNNTVRGQYGA--GEIGGV-SVPgyleeEGVdkD 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   337 SLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNRAYCTQSERhwvpEQSRCLPQQIIFYIGHGElghpA 416
Cdd:TIGR00871 309 SNTETFAALKLEIDNWRWAGVPFYLRTGKRLPEKVTEIRIQFRDVPSLLFKAN----ERDANPRNALVIRIQPDE----G 380

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   417 ILVSRNLFKPSLpTQKWKEVQ-DQPGLRLFGRPLSdyyayrpvreqDAYSTLLSHIFHCRKESFITTENLLASWVFWTPL 495
Cdd:TIGR00871 381 VYLKFNAKKPGL-NFETRPVKlDFSYASRFGELLP-----------EAYERLLLDALLGDHTLFARDDEVEEAWRIVTPI 448

                         490
                  ....*....|....*...
gi 31982147   496 LDSLAF---EVPRPYPGG 510
Cdd:TIGR00871 449 LEAWAAnkgPSPPNYPAG 466
PRK05722 PRK05722
glucose-6-phosphate 1-dehydrogenase; Validated
 33-510 2.44e-82

glucose-6-phosphate 1-dehydrogenase; Validated


Pssm-ID: 235579 [Multi-domain]  Cd Length: 495  Bit Score: 272.00  E-value: 2.44e-82
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   33 IILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKVLESLscpKDLVPSRCDELKGQ-FL 108
Cdd:PRK05722  12 LVIFGATGDLARRKLLPALYNLYKA----GLlpeDFRIIGVARR-DWSDEDFREVVREAL---KEFARTPFDEEVWErFL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  109 QLSQYRQ--LKTVEDYQTLNKDIETQVQQDGLwEAGRIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDHL 186
Cdd:PRK05722  84 SRLYYVSgdVTDPESYERLKELLEELDEERGT-GGNRVFYLATPPSLFGTICENLAAAGLNEGGGWRRVVIEKPFGHDLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  187 SAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNrkAL-DGLWNRHHVERVEIILKETIDAEGRASFYEEYGVI 265
Cdd:PRK05722 163 SARELNDQVGEVFKEEQIYRIDHYLGKETVQNLLALRFAN--ALfEPLWNRNYIDHVQITVAETVGVEGRGGYYDKSGAL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  266 RDTLQNHLTEILTLVAMELPLNIsSSAAVLQHKLWAFQALRGLQ----KSSAILGQYQA--YSGQVRRELQKPDGF--QS 337
Cdd:PRK05722 241 RDMVQNHLLQLLALVAMEPPASL-DADSIRDEKVKVLRALRPITpedvKENTVRGQYTAgwIGGKPVPGYREEEGVnpDS 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  338 LTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKnrayctqserhwvpeqsrCLPQQiIFYIGHGELgHPAI 417
Cdd:PRK05722 320 TTETFVALKLEIDNWRWAGVPFYLRTGKRLPKKVTEIVIVFK------------------PPPHN-LFEESAEEL-GPNK 379

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  418 LVSRnlfkpslptqkwkeVQD-----------QPGLRLFGRPLS---DYYAYRPVREQDAYSTLL-------SHIFHCRK 476
Cdd:PRK05722 380 LVIR--------------IQPdegislrfnakVPGEGMELRPVKldfSYSEAFGEASPEAYERLLldvmlgdQTLFVRRD 445

                        490       500       510
                 ....*....|....*....|....*....|....*...
gi 31982147  477 EsfittenLLASWVFWTPLLDslAFEV----PRPYPGG 510
Cdd:PRK05722 446 E-------VEAAWKWVDPILE--AWEAdggpPPPYPAG 474
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 567-790 5.91e-79

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 253.25  E-value: 5.91e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 567 EELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGhYSFPWAHTHLWLVDERCVPLSDPDSNFQGLQAHL 646
Cdd:cd01400   1 EALAEALADRIAEALAAAIAKRGRFSLALSGGSTPKPLYELLAAA-PALDWSKVHVFLGDERCVPPDDPDSNYRLAREAL 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 647 LQHVRVPYYNIHPMPVHLHqrlcaeEDQGAQTYASEISALVANS-SFDLVLLGMGTDGHTASLFPQSP-TGLDGDQLVVL 724
Cdd:cd01400  80 LSHVAIPAANIHPIPTELG------PEDAAAAYEKELRALFGGVpPFDLVLLGMGPDGHTASLFPGHPaLLEETDRLVVA 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 31982147 725 TE-SPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSGQLVWYM 790
Cdd:cd01400 154 VTdSPKPPPERITLTLPVLNNARRVVFLVTGAEKAEA---LKRAlaGPDPEELPAARVLPRPGEVLWFL 219
Zwf COG0364
Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; ...
 33-380 9.89e-77

Glucose-6-phosphate 1-dehydrogenase [Carbohydrate transport and metabolism]; Glucose-6-phosphate 1-dehydrogenase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440133 [Multi-domain]  Cd Length: 495  Bit Score: 256.93  E-value: 9.89e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  33 IILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKVLESLscpKDLVPSRCDELK-GQFL 108
Cdd:COG0364  12 LVIFGATGDLARRKLLPALYNLYRD----GLlpeGFRIIGVARR-DWSDEEFREEVREAL---EEFSRKPFDEEVwERFL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 109 QLSQYRQL--KTVEDYQTLNKDIEtqvQQDGLWEAG-RIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDH 185
Cdd:COG0364  84 ERLHYVSGdfTDPEGYERLKELLE---ELDEERTPGnRVFYLATPPSLFGPICENLGAAGLATEGGWRRVVIEKPFGHDL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 186 LSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVI 265
Cdd:COG0364 161 ASARELNDELGRVFDESQIYRIDHYLGKETVQNLLALRFANA-LFEPLWNRNYIDHVQITVAETVGVEGRGGYYDGAGAL 239

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 266 RDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKS----SAILGQYQAysGQVRRELQKP----DGF-- 335
Cdd:COG0364 240 RDMVQNHLLQLLCLVAMEPPASLDAD-AIRDEKVKVLRALRPITPEdvaeNTVRGQYTA--GWIGGEPVPGyreePGVap 316

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 31982147 336 QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKN 380
Cdd:COG0364 317 DSTTETFVALKLEIDNWRWAGVPFYLRTGKRLPERVTEIVIQFKP 361
PLN02640 PLN02640
glucose-6-phosphate 1-dehydrogenase
 23-511 1.29e-71

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215344 [Multi-domain]  Cd Length: 573  Bit Score: 245.31  E-value: 1.29e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   23 QAQELKGHVSIILLGATGDLAKKYLWQGLFQLYLdEAGKGHSFSFHGAALTAPQQgQKLMDKVLESLSCPKDlVPSRCDE 102
Cdd:PLN02640  81 HAEKGESTLSITVVGASGDLAKKKIFPALFALFY-EDWLPENFTVFGYARTKLTD-EELRDMISSTLTCRID-QRENCGD 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  103 LKGQFLQLSQYR--QLKTVEDYQTLNKDIETQvqqdglwEAG----RIFYFSVPPFAYADIARNINSSCRPHPGaWLRVV 176
Cdd:PLN02640 158 KMDQFLKRCFYHsgQYDSEEDFAELNKKLKEK-------EAGklsnRLFYLSIPPNIFVDVVRCASLRASSENG-WTRVI 229

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  177 FEKPFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRA 256
Cdd:PLN02640 230 VEKPFGRDSESSGELTRCLKQYLTEEQIFRIDHYLGKELVENLSVLRFSNL-VFEPLWSRNYIRNVQLIFSEDFGTEGRG 308

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  257 SFYEEYGVIRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAILGQYQAYSGQVRR------ELQ 330
Cdd:PLN02640 309 GYFDNYGIIRDIMQNHLLQILALFAMETPVSLDAE-DIRNEKVKVLRSMKPLQLEDVIVGQYKGHSKGGKSypaytdDPT 387

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  331 KPDGfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKN-------RAYCTQSERHWVPEQSRCLPQQi 403
Cdd:PLN02640 388 VPKH--SLTPTFAAAALFINNARWDGVPFLMKAGKALHTRRAEIRVQFRHvpgnlykRNFGTDLDKATNELVLRVQPDE- 464

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  404 ifyighgelghpAILVSRNLFKPSLptqkwkevqdqpGLRLFGRPLSDYYAYRPVRE-QDAYSTLLSHIFHCRKESFITT 482
Cdd:PLN02640 465 ------------AIYLKINNKVPGL------------GMRLDRSDLNLLYRARYPREiPDAYERLLLDAIEGERRLFIRS 520

                        490       500       510
                 ....*....|....*....|....*....|.
gi 31982147  483 ENLLASWVFWTPLLDSLAFE--VPRPYPGGA 511
Cdd:PLN02640 521 DELDAAWALFTPLLKELEEKkiIPELYPYGS 551
PLN02333 PLN02333
glucose-6-phosphate 1-dehydrogenase
 31-511 3.54e-71

glucose-6-phosphate 1-dehydrogenase


Pssm-ID: 215191 [Multi-domain]  Cd Length: 604  Bit Score: 244.89  E-value: 3.54e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   31 VSIILLGATGDLAKKYLWQGLFQLYLDEAGKGHsFSFHGAALTAPQQGQkLMDKVLESLSCPKDlVPSRCDELKGQFLQL 110
Cdd:PLN02333 118 VSITVVGASGDLAKKKIFPALFALYYEGCLPEH-FTIFGYARSKMTDAE-LRNMVSKTLTCRID-KRENCGEKMEEFLKR 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  111 SQYR--QLKTVEDYQTLNKDIEtqvQQDGLWEAGRIFYFSVPPFAYADIARNINSSCRPHPGaWLRVVFEKPFGHDHLSA 188
Cdd:PLN02333 195 CFYHsgQYDSQEHFAELDKKLK---EHEGGRVSNRLFYLSIPPNIFVDAVKCASSSASSVNG-WTRVIVEKPFGRDSESS 270

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  189 QQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVIRDT 268
Cdd:PLN02333 271 AALTKSLKQYLEEDQIFRIDHYLGKELVENLSVLRFSNL-IFEPLWSRQYIRNVQFIFSEDFGTEGRGGYFDNYGIIRDI 349

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  269 LQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAILGQYQAYS-GQVR-----RELQKPDGfqSLTPTF 342
Cdd:PLN02333 350 MQNHLLQILALFAMETPVSLDAE-DIRNEKVKVLRSMRPIQLEDVVIGQYKSHTkGGVTypaytDDKTVPKG--SLTPTF 426

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  343 AGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFK-------NRAYCTQSERHWVPEQSRCLPQQiifyighgelghp 415
Cdd:PLN02333 427 AAAALFIDNARWDGVPFLMKAGKALHTKSAEIRVQFRhvpgnlyNRNFGTDLDQATNELVIRVQPDE------------- 493

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  416 AILVSRNLFKPSLptqkwkevqdqpGLRLFGRPLSDYYAYRPVRE-QDAYSTLLSHIFHCRKESFITTENLLASWVFWTP 494
Cdd:PLN02333 494 AIYLKINNKVPGL------------GMRLDRSNLNLLYAARYSKEiPDAYERLLLDAIEGERRLFIRSDELDAAWALFTP 561

                        490
                 ....*....|....*....
gi 31982147  495 LLDSLAFE--VPRPYPGGA 511
Cdd:PLN02333 562 LLKELEEKkiIPEYYPYGS 580
PRK12853 PRK12853
glucose-6-phosphate dehydrogenase;
33-510 1.79e-68

glucose-6-phosphate dehydrogenase;


Pssm-ID: 237233 [Multi-domain]  Cd Length: 482  Bit Score: 234.02  E-value: 1.79e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   33 IILLGATGDLAKKYLWQGLFQLYLDEAgKGHSFSFHGAALTAPQQGQ--KLMDKVLESLScPKDLVPSRCDelkgQFLQL 110
Cdd:PRK12853  11 LVIFGATGDLARRKLLPALYRLARAGL-LPEDLRIIGVGRDDWSDEQwrARVRESLRAFG-ADGFDDAVWD----RLAAR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  111 SQYRQ--LKTVEDYQTLNKDIETQVQqdglweagRIFYFSVPPFAYADIARNINSS-CRPhpgAWLRVVFEKPFGHDHLS 187
Cdd:PRK12853  85 LSYVQgdVTDPADYARLAEALGPGGN--------PVFYLAVPPSLFAPVVENLGAAgLLP---EGRRVVLEKPFGHDLAS 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  188 AQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKETIDAEGRASFYEEYGVIRD 267
Cdd:PRK12853 154 ARALNATLAKVFDEDQIYRIDHFLGKETVQNLLALRFANA-LLEPLWNRNHIDHVQITVAETLGVEGRGGFYDATGALRD 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  268 TLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSSAIL--GQYQAysGQVRRE-----LQKPDGF-QSLT 339
Cdd:PRK12853 233 MVQNHLLQLLALVAMEPPASFDAD-AVRDEKAKVLRAIRPLDPDDVHTvrGQYTA--GTVGGEpvpgyREEPGVDpDSRT 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  340 PTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKnRAYCTQserhwVPEQSRCLPQQIIFYIGHGELGHPAILV 419
Cdd:PRK12853 310 ETFVALKLEIDNWRWAGVPFYLRTGKRLAERRTEIVITFK-PVPHAL-----FRGTGVEPPNRLVIRLQPDEGISLELNV 383

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  420 SRnlfkpslptqkwkevqdqPGLRLFGRPLSDYYAYR-PVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDS 498
Cdd:PRK12853 384 KR------------------PGPGMRLRPVELDADYAdDERPLEAYERLLLDVLRGDPTLFVRADEVEAAWRIVDPVLDA 445

                        490
                 ....*....|....
gi 31982147  499 LA--FEVPRPYPGG 510
Cdd:PRK12853 446 WAadPVPPHEYPAG 459
PRK12854 PRK12854
glucose-6-phosphate 1-dehydrogenase; Provisional
 23-520 6.97e-63

glucose-6-phosphate 1-dehydrogenase; Provisional


Pssm-ID: 237234 [Multi-domain]  Cd Length: 484  Bit Score: 219.14  E-value: 6.97e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   23 QAQELKGHVSIILLGATGDLAKKYLWQGLFQLYLDE--------AGKGHSfsfhgaALTAPQQGQKLMDKVLESLSCPKD 94
Cdd:PRK12854   4 QGTGPAPPTVFVLFGATGDLAKRKLLPGLFHLARAGllppdwriVGTGRG------DVSAEAFREHARDALDEFGARKLD 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   95 lvpsrcDELKGQFLQLSQYRQLK-TVEDYQTLnKDIETQVQQDGLWEAGRIFYFSVPPFAYADIARNInsscrphPGAWL 173
Cdd:PRK12854  78 ------DGEWARFAKRLRYVPGGfLSAGPGAL-AAAVAAARAELGGDARLVHYLAVPPSAFLDVTRAL-------GEAGL 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  174 ----RVVFEKPFGHDHLSAQQLASELGSFFQEEEMYRVDHYLGKQAVAQILPFRDQNRkALDGLWNRHHVERVEIILKET 249
Cdd:PRK12854 144 aegsRVVMEKPFGTDLASAEALNAAVHEVFDESQIFRIDHFLGKEAAQNILAFRFANG-LFEPIWNREFIDHVQIDVPET 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  250 IDAEGRASFYEEYGVIRDTLQNHLTEILTLVAMELPLNIsSSAAVLQHKLWAFQALRGLQKSSAILGQYQAYsgqvRREl 329
Cdd:PRK12854 223 LGVDTRAAFYDATGAYRDMVVTHLFQVLAFVAMEPPTAL-EPDAISEEKNKVFRSMRPLDPAEVVRGQYSGY----RDE- 296

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  330 qkpDGF--QSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFKNrayctqserhwvpeqsrclPQQIIFYI 407
Cdd:PRK12854 297 ---PGVapDSTTETFVALKVWIDNWRWAGVPFYLRTGKRMAEGQRIISIAFRE-------------------PPYSMFPA 354

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  408 GHGELGHPAILVsrnlFKPSLPTQKWKEVQDQ---PGLRLfgRPLSDYYAYRPVREQ----DAYSTLLSHIFHCRKESFI 480
Cdd:PRK12854 355 GSVGAQGPDHLT----FDLADNSKVSLSFYGKrpgPGMRL--DKLSLQFSLKDTGPKgdvlEAYERLILDALRGDHTLFT 428

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|.
gi 31982147  481 TTENLLASWVFWTPLLDSLAfeVPRPYPGG-----------AENGQLLDFE 520
Cdd:PRK12854 429 TADGIESLWEVSQPLLEDPP--PVKPYAPGswgpnaihqlaAPDAWRLPFE 477
G6PD_C pfam02781
Glucose-6-phosphate dehydrogenase, C-terminal domain;
233-510 4.37e-62

Glucose-6-phosphate dehydrogenase, C-terminal domain;


Pssm-ID: 460694  Cd Length: 295  Bit Score: 210.76  E-value: 4.37e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   233 LWNRHHVERVEIILKETIDAEGRASFYEEYGVIRDTLQNHLTEILTLVAMELPLNISSSaAVLQHKLWAFQALRGLQKSS 312
Cdd:pfam02781  13 LWNRNYIDHVQITVAETLGVEGRGGYYDQAGALRDMVQNHLLQLLALVAMEPPVSFDAE-DIRDEKVKVLRSLRPITPED 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   313 ----AILGQYQAysGQVRRELQK---------PDgfqSLTPTFAGVLVHIDNLRWEGVPFILMSGKALDERVGYVRIVFK 379
Cdd:pfam02781  92 vednVVRGQYGA--GWIGGEPVPgyreeegvpPD---SRTETFAALKLFIDNWRWAGVPFYLRTGKRLPERVTEIRIQFK 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   380 NrayctqserhwVP-----EQSRCLPQQIIFYIGHGElghpAILVSRNLFKpslptqkwkevqdqPGLRLFGRPLS---D 451
Cdd:pfam02781 167 D-----------VPhnlfrDPGTLPPNELVIRIQPDE----GIYLKFNAKV--------------PGLGMRLRPVEldfS 217

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 31982147   452 YYAYRPVREQDAYSTLLSHIFHCRKESFITTENLLASWVFWTPLLDSLAFEVPRPYPGG 510
Cdd:pfam02781 218 YSDRFGERIPEAYERLLLDVMRGDQTLFVRSDEVEAAWRIVDPILEAWDEEKPPPYPAG 276
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 566-794 1.04e-55

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 191.91  E-value: 1.04e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 566 PEELISKLASDIEAAAVQAVRHFGKFHLALSGGSSPIALFQQLATGHYS--FPWAHTHLWLVDERC-VPLSDPDSNFQGL 642
Cdd:COG0363  10 AEELAAAAAERAAERIAEAIAEKGRAVLGLAGGSTPLGLYEELARLHKEggLDWSRVHVFNLDEYVgLPPDHPQSNRRFM 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 643 QAHLLQHVRVPYYNIHPMPVHLhqrlcAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPTGLDGDQLV 722
Cdd:COG0363  90 REALLDHVDIPPENIHIPDGEA-----EDPEAAAARYEALIAEA---GGIDLQLLGIGEDGHIAFNFPGSPFLSETDRVV 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 723 VLTESPFR------------PHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRV--GHEPKKWPISGVVPLSgQLVW 788
Cdd:COG0363 162 TLDESTRQanarffgsipkvPPQAITLGIPTIMKAREILLLATGENKAEA---VAAAleGPVTEEVPASILQGHP-NVTW 237


                ....*.
gi 31982147 789 YMDYEA 794
Cdd:COG0363 238 FLDEAA 243
G6PD_N pfam00479
Glucose-6-phosphate dehydrogenase, NAD binding domain;
34-216 1.94e-41

Glucose-6-phosphate dehydrogenase, NAD binding domain;


Pssm-ID: 459827 [Multi-domain]  Cd Length: 178  Bit Score: 149.50  E-value: 1.94e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147    34 ILLGATGDLAKKYLWQGLFQLYLDeagkGH---SFSFHGAALTaPQQGQKLMDKVLESLSCPKDlvpsRCDELKGQFLQL 110
Cdd:pfam00479   1 VIFGATGDLAKRKLFPALYNLYRD----GLlpeGFRIIGVARR-DLSDEEFRERVREALKEFKE----LDEEKWDRFLER 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147   111 SQYRQ--LKTVEDYQTLNKDIEtqvQQDGLWEAGRIFYFSVPPFAYADIARNINSSCRPHPGAWLRVVFEKPFGHDHLSA 188
Cdd:pfam00479  72 LHYVSgdFDDPESYEKLKERLE---EHEDETRGNRLFYLAVPPSLFGPIAENLGRAGLSEEGGWRRVVIEKPFGHDLESA 148

                         170       180
                  ....*....|....*....|....*...
gi 31982147   189 QQLASELGSFFQEEEMYRVDHYLGKQAV 216
Cdd:pfam00479 149 RELNDQLAKVFKEEQIYRIDHYLGKETV 176
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 567-794 1.64e-30

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 121.12  E-value: 1.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  567 EELISKLASDIEAAAVQAVRHFGKFHLALSGGSSpIALFQQLATGHY--SFPWAHTHLWLVDERCVPLSDPDSNFQGLQA 644
Cdd:PLN02360  20 DELSTDLAEYIAELSEASVKERGVFAIALSGGSL-ISFMGKLCEAPYnkTVDWAKWYIFWADERVVAKNHADSNYKLAKD 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  645 HLLQHVRVPYYNIHPmpvhLHQRLCAEEdqGAQTYASEISALVANSS-----------FDLVLLGMGTDGHTASLFPQSP 713
Cdd:PLN02360  99 GLLSKVPVVPSHVYS----INDTVTAEE--AATDYEFAIRQLVKTRTigvsdisdcpkFDLILLGMGSDGHVASLFPNHP 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  714 T-GLDGDQLVVLTESPFRPHQRMSLSLPLINRAKKVAVLVMGRTKREITTL-VSRVGHEP--KKWPISGVVPLSGQLVWY 789
Cdd:PLN02360 173 AlEEKDDWVTFITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLaIDDVTEGPdaPSLPARMVQPTKGKLVWF 252


                 ....*
gi 31982147  790 MDYEA 794
Cdd:PLN02360 253 LDKPA 257
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 578-777 5.98e-15

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 74.83  E-value: 5.98e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 578 EAAA---VQAVRHFGKFHLALSGGSSPIALFQQLATGHYS--FPWAHTHLWLVDERcVPLS--DPDSNFQGLQAHLLQHV 650
Cdd:cd01399   5 EAAAeliAELIREKPPAVLGLATGSTPLGVYEELIELHKEggLSFSNVTTFNLDEY-VGLPpdHPQSYHYFMRENLFDHI 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 651 RVPYYNIHPMPVhlhqrLCAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTAslFPQSPTGLDGD-QLVVLTES-- 727
Cdd:cd01399  84 DIKPENIHIPDG-----NAADLEAECRRYEALIAEA---GGIDLQLLGIGENGHIG--FNEPGSSLDSRtRVVTLDEStr 153

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 31982147 728 -----PFR-----PHQRMSLSLPLINRAKKVAVLVMGRTKREIttlVSRVGHEP--KKWPIS 777
Cdd:cd01399 154 qanarFFDgdedvPTQAITMGIGTIMKAKEILLLATGEGKAEA---VKKALEGPvtEECPAS 212
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 590-705 7.94e-09

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 55.82  E-value: 7.94e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147 590 KFHLALSGGSSPIALFQQLATGHYSFPWAHTHLWLVDERCVPLSDPDSNFQGLQAHLLQHVRVPYYNIHPMPVHLhqrlc 669
Cdd:cd00458  21 DMVIGLGTGSTPAYFYKLLGEKLKRGEISDIVGFPTDERYVPLDSDQSNFRQAKLLAFEHDIIPASNVHYVDTSL----- 95

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 31982147 670 AEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHT 705
Cdd:cd00458  96 PIEKACEKYEREILDQV---DAIDLAVDGAGYRAGT 128
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 591-777 3.76e-07

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 52.07  E-value: 3.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  591 FHLALSGGSSPIALFQQLATGH----YSFpwAHTHLWLVDERC-VPLSDPDSNFQGLQAHLLQHVrvpyyNIHPMPVHLH 665
Cdd:PTZ00285  35 FVLGLPTGSTPLPTYQELIRAYregrVSF--SNVVTFNMDEYVgLPRDHPQSYHYFMKENFFDHV-----DIKEENRHIL 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  666 QRLCAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTASLFPQSPtgLDGDQLVV-LTESPFR-------------P 731
Cdd:PTZ00285 108 NGTAPDLEEECRRYEEKIRAV---GGIDLFLAGIGTDGHIAFNEPGSS--LDSRTRVKsLNQETIDanarffgndiskvP 182

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 31982147  732 HQRMSLSLPLINRAKKVAVLVMGRTKREITT--LVSRVGHepkKWPIS 777
Cdd:PTZ00285 183 TMALTVGIRTIMEAREVLLLATGASKAIAVArcVEGGVTH---MCPAS 227
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 570-777 8.61e-06

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 47.90  E-value: 8.61e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  570 ISKLASDIEAAAVQA--VRHFGKFHLALSGGSSPIALFQQLATGHYS--FPWAHTHLWLVDE-RCVPLSDPDS--NFqgL 642
Cdd:PRK00443  12 VGKWAARHIANRINAflPTKERPFVLGLATGSSPLETYKALIELHKAgkVDFSRVTTFNLDEyVGLPADHPESyrYF--M 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  643 QAHLLQHVrvpyyNIHPMPVHLHQRLCAEEDQGAQTYASEIsalVANSSFDLVLLGMGTDGHTAslFPQSPTGLDGDQLV 722
Cdd:PRK00443  90 RENFFDHV-----DIPPENINLLNGNAPDPEAECRRYEEKI---KSAGGIDLQILGIGENGHIA--FNEPGSSFASRTRI 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 31982147  723 V-LTESPFR-------------PHQRMSLSLPLINRAKKVAVLVMGRTKREIT--TLVSRVGHEpkkWPIS 777
Cdd:PRK00443 160 KtLTEDTRIansrffdgdieqvPKYALTVGVGTILDAKEIMLLAPGHNKAEAVkaAVEGPVNHM---WPAS 227
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 566-760 2.76e-05

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 47.72  E-value: 2.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  566 PEELISKLASDIeAAAVQAVRHFGKFH-LALSGGSSPIALFQQLATGH----YSFPwaHTHLWLVDERcVPLS--DPDSN 638
Cdd:PRK02122  36 SEEASRAVAQEI-ATLIRERQAEGKPCvLGLATGSSPIGVYAELIRMHreegLSFK--NVITFNLDEY-YPMQpdSLQSY 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  639 FQGLQAHLLQHVRVPYYNIHPMPVHLHQrlcAEEDQGAQTYASEISALvanSSFDLVLLGMGTDGHTAslFPQSPTGLD- 717
Cdd:PRK02122 112 HRFMKENLFDHVDIPPENIHIPDGTIPK---EEIDEYCRDYEEKIEAA---GGIDFQLLGIGRTGHIG--FNEPGSGRNs 183

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 31982147  718 GDQLVVLTESPFR------------PHQRMSLSLPLINRAKKVAVLVMGRTKREI 760
Cdd:PRK02122 184 RTRLVTLDHITRRdaasdffgeenvPRKAITMGVGTILKARRIVLLAWGEHKAPI 238
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
590-704 1.29e-03

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 41.28  E-value: 1.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 31982147  590 KFHLALSGGSSPIALFQQLATGHYSFPW-AHTHLWLVDErcVPLSDPDS---NFQGLQAHLLQHVRVPYYNIHPMPVhlh 665
Cdd:PRK12358  29 RVNLAITAGSTPKGMYEYLITLVKGKAWyDNVHYYNFDE--IPFRGKEGegvTITNLRNLFFTPAGIKEENIHKLTI--- 103

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 31982147  666 qrlcaeedqgaQTYASEISALVANSSFDLVLLGMGTDGH 704
Cdd:PRK12358 104 -----------DNYREHDQKLARDGGLDLVVLGLGADGH 131
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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