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Conserved domains on  [gi|116063542|ref|NP_775603|]
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kelch domain-containing protein 7A [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BACK super family cl28903
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 426-497 7.02e-30

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


The actual alignment was detected with superfamily member cd18484:

Pssm-ID: 475122  Cd Length: 77  Bit Score: 112.86  E-value: 7.02e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116063542 426 LDLGNCYEMLTLAKRQGLETLKEAAYKVLSDNYLQVLRSPDIYGGLSGAERELILQRRF-RGHKRLVVADMCP 497
Cdd:cd18484    1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLeAGRACLVVAELND 73
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
506-725 1.25e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 98.69  E-value: 1.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 506 CYDNVQDAWHPLAQLPPEAMSRGCALcTLFNYLFVVSGCQ--EPGGQPSNRVFCYNPLTAIWSEVCPLNQARPHCRLVAL 583
Cdd:COG3055   42 VYDPATNTWSELAPLPGPPRHHAAAV-AQDGKLYVFGGFTgaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 584 EGHLYAIGGE----CLNTVERYDPRLDRWTFAPPLPNDTFALAhTATVCANEIFVTGGSlrylllRFSTQEQRWWAGPTG 659
Cdd:COG3055  121 DGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTPRDHLA-AAVLPDGKILVIGGR------NGSGFSNTWTTLAPL 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116063542 660 GSKDRTAEMVAVNGFLYRFDLNRSLGISVYRCSASTRLWYecATYRLPYPD-AFQCAVVDDHIYCVG 725
Cdd:COG3055  194 PTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWT--ALGELPTPRhGHAAVLTDGKVYVIG 258
 
Name Accession Description Interval E-value
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 426-497 7.02e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 112.86  E-value: 7.02e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116063542 426 LDLGNCYEMLTLAKRQGLETLKEAAYKVLSDNYLQVLRSPDIYGGLSGAERELILQRRF-RGHKRLVVADMCP 497
Cdd:cd18484    1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLeAGRACLVVAELND 73
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
506-725 1.25e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 98.69  E-value: 1.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 506 CYDNVQDAWHPLAQLPPEAMSRGCALcTLFNYLFVVSGCQ--EPGGQPSNRVFCYNPLTAIWSEVCPLNQARPHCRLVAL 583
Cdd:COG3055   42 VYDPATNTWSELAPLPGPPRHHAAAV-AQDGKLYVFGGFTgaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 584 EGHLYAIGGE----CLNTVERYDPRLDRWTFAPPLPNDTFALAhTATVCANEIFVTGGSlrylllRFSTQEQRWWAGPTG 659
Cdd:COG3055  121 DGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTPRDHLA-AAVLPDGKILVIGGR------NGSGFSNTWTTLAPL 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116063542 660 GSKDRTAEMVAVNGFLYRFDLNRSLGISVYRCSASTRLWYecATYRLPYPD-AFQCAVVDDHIYCVG 725
Cdd:COG3055  194 PTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWT--ALGELPTPRhGHAAVLTDGKVYVIG 258
PHA03098 PHA03098
kelch-like protein; Provisional
 527-725 3.13e-13

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 72.88  E-value: 3.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 527 RGCALCTLFNYLFVVSGCQEPGGQPSNRVFCYNPLTAIWSEVCPLNQARPHCRLVALEGHLYAIGG----ECLNTVERYD 602
Cdd:PHA03098 285 VYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsISLNTVESWK 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 603 PRLDRWTFAPPLPNDTFALAhtATVCANEIFVTGGSLRYLLL-----RFSTQEQRWWAG-PT-----GGSKDRTAEMVAV 671
Cdd:PHA03098 365 PGESKWREEPPLIFPRYNPC--VVNVNNLIYVIGGISKNDELlktveCFSLNTNKWSKGsPLpishyGGCAIYHDGKIYV 442

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116063542 672 NGFLYRFDLNRSLGIsVYRCSASTRLWYECATYRLPYPDAFQCaVVDDHIYCVG 725
Cdd:PHA03098 443 IGGISYIDNIKVYNI-VESYNPVTNKWTELSSLNFPRINASLC-IFNNKIYVVG 494
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 574-615 5.09e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.61  E-value: 5.09e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 116063542  574 ARPHCRLVALEGHLYAIGG----ECLNTVERYDPRLDRWTFAPPLP 615
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
Kelch smart00612
Kelch domain;
586-616 1.56e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 48.32  E-value: 1.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 116063542   586 HLYAIGG----ECLNTVERYDPRLDRWTFAPPLPN 616
Cdd:smart00612   1 KIYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPT 35
 
Name Accession Description Interval E-value
BACK_KBTBD11_CMLAP cd18484
BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein ...
 426-497 7.02e-30

BACK (BTB and C-terminal Kelch) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11, also termed chronic myelogenous leukemia-associated protein (CMLAP), or Kelch domain-containing protein 7B, or KLHDC7C, is a BTB-Kelch family protein. Its function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk; KBTBD11 may function as a tumor suppressor. KBTBD11 hypomethylation may also be a potential target for differentiating between the mostly fatal TCF3-HLF and curable TCF3-PBX1 pediatric acute lymphoblastic leukemia subtypes.


Pssm-ID: 350559  Cd Length: 77  Bit Score: 112.86  E-value: 7.02e-30
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 116063542 426 LDLGNCYEMLTLAKRQGLETLKEAAYKVLSDNYLQVLRSPDIYGGLSGAERELILQRRF-RGHKRLVVADMCP 497
Cdd:cd18484    1 LDLGNCYEVLTLAKKQRLNELREAAYKFMSDNYLQVLREPAVYGRLSGAERELILRRRLeAGRACLVVAELND 73
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
506-725 1.25e-22

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 98.69  E-value: 1.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 506 CYDNVQDAWHPLAQLPPEAMSRGCALcTLFNYLFVVSGCQ--EPGGQPSNRVFCYNPLTAIWSEVCPLNQARPHCRLVAL 583
Cdd:COG3055   42 VYDPATNTWSELAPLPGPPRHHAAAV-AQDGKLYVFGGFTgaNPSSTPLNDVYVYDPATNTWTKLAPMPTPRGGATALLL 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 584 EGHLYAIGGE----CLNTVERYDPRLDRWTFAPPLPNDTFALAhTATVCANEIFVTGGSlrylllRFSTQEQRWWAGPTG 659
Cdd:COG3055  121 DGKIYVVGGWddggNVAWVEVYDPATGTWTQLAPLPTPRDHLA-AAVLPDGKILVIGGR------NGSGFSNTWTTLAPL 193

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 116063542 660 GSKDRTAEMVAVNGFLYRFDLNRSLGISVYRCSASTRLWYecATYRLPYPD-AFQCAVVDDHIYCVG 725
Cdd:COG3055  194 PTARAGHAAAVLGGKILVFGGESGFSDEVEAYDPATNTWT--ALGELPTPRhGHAAVLTDGKVYVIG 258
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
513-637 5.89e-16

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 79.04  E-value: 5.89e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 513 AWHPLAQLPpEAMSRGCALcTLFNYLFVVSGcqEPGGQPSNRVFCYNPLTAIWSEVCPLN-QARPHCRLVALEGHLYAIG 591
Cdd:COG3055    2 TWSSLPDLP-TPRSEAAAA-LLDGKVYVAGG--LSGGSASNSFEVYDPATNTWSELAPLPgPPRHHAAAVAQDGKLYVFG 77

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116063542 592 G--------ECLNTVERYDPRLDRWTFAPPLPndTFALAHTATVCANEIFVTGG 637
Cdd:COG3055   78 GftganpssTPLNDVYVYDPATNTWTKLAPMP--TPRGGATALLLDGKIYVVGG 129
PHA03098 PHA03098
kelch-like protein; Provisional
 527-725 3.13e-13

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 72.88  E-value: 3.13e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 527 RGCALCTLFNYLFVVSGCQEPGGQPSNRVFCYNPLTAIWSEVCPLNQARPHCRLVALEGHLYAIGG----ECLNTVERYD 602
Cdd:PHA03098 285 VYCFGSVVLNNVIYFIGGMNKNNLSVNSVVSYDTKTKSWNKVPELIYPRKNPGVTVFNNRIYVIGGiynsISLNTVESWK 364

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 603 PRLDRWTFAPPLPNDTFALAhtATVCANEIFVTGGSLRYLLL-----RFSTQEQRWWAG-PT-----GGSKDRTAEMVAV 671
Cdd:PHA03098 365 PGESKWREEPPLIFPRYNPC--VVNVNNLIYVIGGISKNDELlktveCFSLNTNKWSKGsPLpishyGGCAIYHDGKIYV 442

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 116063542 672 NGFLYRFDLNRSLGIsVYRCSASTRLWYECATYRLPYPDAFQCaVVDDHIYCVG 725
Cdd:PHA03098 443 IGGISYIDNIKVYNI-VESYNPVTNKWTELSSLNFPRINASLC-IFNNKIYVVG 494
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
565-725 6.01e-13

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 69.80  E-value: 6.01e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 565 WSEVCPLNQARPHCRLVALEGHLYAIGG----ECLNTVERYDPRLDRWTFAPPLPndTFALAHTATV-CANEIFVTGG-- 637
Cdd:COG3055    3 WSSLPDLPTPRSEAAAALLDGKVYVAGGlsggSASNSFEVYDPATNTWSELAPLP--GPPRHHAAAVaQDGKLYVFGGft 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 638 ----SLRYL--LLRFSTQEQRWWAGPTGGSKDRTAEMVAVNGFLYRF---DLNRSLGiSVYRCSASTRLWYECATyrLPY 708
Cdd:COG3055   81 ganpSSTPLndVYVYDPATNTWTKLAPMPTPRGGATALLLDGKIYVVggwDDGGNVA-WVEVYDPATGTWTQLAP--LPT 157

                        170
                 ....*....|....*....
gi 116063542 709 PDAFQCAVV--DDHIYCVG 725
Cdd:COG3055  158 PRDHLAAAVlpDGKILVIG 176
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
484-640 2.35e-09

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 59.01  E-value: 2.35e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 484 FRGHKRLVVADMCPQDDSGRLCCYDNVQDAWHPLAQLPPEAMSRGCALCTlFNYLFVVSGCQEPGGQPSnrvfcynplta 563
Cdd:COG3055  119 LLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQLAPLPTPRDHLAAAVLP-DGKILVIGGRNGSGFSNT----------- 186

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 116063542 564 iWSEVCPLNQARPHCRLVALEGHLYAIGGEC--LNTVERYDPRLDRWTFAPPLPNDTFalAHTATVCANEIFVTGGSLR 640
Cdd:COG3055  187 -WTTLAPLPTARAGHAAAVLGGKILVFGGESgfSDEVEAYDPATNTWTALGELPTPRH--GHAAVLTDGKVYVIGGETK 262
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 574-615 5.09e-09

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 52.61  E-value: 5.09e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 116063542  574 ARPHCRLVALEGHLYAIGG----ECLNTVERYDPRLDRWTFAPPLP 615
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGfdgnQSLNSVEVYDPETNTWSKLPSMP 46
BACK_KLHL42_KLHDC5 cd18478
BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also ...
 426-521 4.42e-08

BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 42 (KLHL42); KLHL42, also called Cullin-3-binding protein 9 (Ctb9), or Kelch domain-containing protein 5, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL42) E3 ubiquitin ligase complex mediates the ubiquitination and subsequent degradation of KATNA1. KLHL42 is involved in microtubule dynamics throughout mitosis.


Pssm-ID: 350553  Cd Length: 103  Bit Score: 51.69  E-value: 4.42e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 426 LDLGNCYEMLTLAKRQGLETLKEAAYKVLSDNYLQVLRSPDIYGGLSGAeRELILQRRFRGHKRLVV----ADMCPQDDS 501
Cdd:cd18478    1 IRLPNCLELYRLAQVYGLRDLAEACLKFMATHYHPMLRRPEFRPLPSSL-KQQLRERRLRGTPALVAlgdfLGTPLDPYQ 79

                         90       100
                 ....*....|....*....|....
gi 116063542 502 GRLCC---YDNVQDAWHPLA-QLP 521
Cdd:cd18478   80 DEPWSmlrYDEVEQRWLPLAnELP 103
Kelch smart00612
Kelch domain;
586-616 1.56e-07

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 48.32  E-value: 1.56e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 116063542   586 HLYAIGG----ECLNTVERYDPRLDRWTFAPPLPN 616
Cdd:smart00612   1 KIYVVGGfdggQRLKSVEVYDPETNKWTPLPSMPT 35
PHA03098 PHA03098
kelch-like protein; Provisional
 506-616 1.13e-06

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 52.08  E-value: 1.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 116063542 506 CYDNVQDAWHPLAQLPpEAMSRGCALCTlFNYLFVVSGCQ-EPGGQPSNRVFCYNPLTAIWSEVCPLNQARPHCRLVALE 584
Cdd:PHA03098 410 CFSLNTNKWSKGSPLP-ISHYGGCAIYH-DGKIYVIGGISyIDNIKVYNIVESYNPVTNKWTELSSLNFPRINASLCIFN 487

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 116063542 585 GHLYAIGGECL----NTVERYDPRLDRWTFAPPLPN 616
Cdd:PHA03098 488 NKIYVVGGDKYeyyiNEIEVYDDKTNTWTLFCKFPK 523
Kelch_6 pfam13964
Kelch motif;
580-617 1.31e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 40.01  E-value: 1.31e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 116063542  580 LVALEGHLYAIGGEC-----LNTVERYDPRLDRWTFAPPLPND 617
Cdd:pfam13964   7 VVSVGGYIYVFGGYTnaspaLNKLEVYNPLTKSWEELPPLPTP 49
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 427-466 1.43e-04

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 40.34  E-value: 1.43e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 116063542 427 DLGNCYEMLTLAKRQGLETLKEAAYKVLSDNYLQVLRSPD 466
Cdd:cd14733    1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEE 40
Kelch smart00612
Kelch domain;
538-585 9.28e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 37.54  E-value: 9.28e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 116063542   538 LFVVSGCqePGGQPSNRVFCYNPLTAIWSEVCPLNQARPHCRLVALEG 585
Cdd:smart00612   2 IYVVGGF--DGGQRLKSVEVYDPETNKWTPLPSMPTPRSGHGVAVING 47
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 525-568 1.33e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 37.21  E-value: 1.33e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 116063542  525 MSRGCALCTLFNYLFVVSGCQepGGQPSNRVFCYNPLTAIWSEV 568
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFD--GNQSLNSVEVYDPETNTWSKL 42
Kelch_6 pfam13964
Kelch motif;
532-575 2.72e-03

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 36.54  E-value: 2.72e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 116063542  532 CTLFNYLFVVSGCQEPGGQPSNRVFCYNPLTAIWSEVCPLNQAR 575
Cdd:pfam13964   7 VVSVGGYIYVFGGYTNASPALNKLEVYNPLTKSWEELPPLPTPR 50
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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