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Conserved domains on  [gi|28373082|ref|NP_777629|]
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CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform g [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 140-346 5.55e-165

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467709  Cd Length: 207  Bit Score: 459.00  E-value: 5.55e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 140 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 219
Cdd:cd23981   1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 220 FKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCD 299
Cdd:cd23981  81 FKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 28373082 300 EVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 346
Cdd:cd23981 161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 140-346 5.55e-165

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 459.00  E-value: 5.55e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 140 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 219
Cdd:cd23981   1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 220 FKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCD 299
Cdd:cd23981  81 FKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 28373082 300 EVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 346
Cdd:cd23981 161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 100-351 2.39e-87

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 263.70  E-value: 2.39e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082   100 KWARIREFVPPFgiKGQDNLIKAILSVTKeyrltpaLDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGF 179
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082   180 EKDVGSKTTLRITYPEGAMQR-------PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSAS---DGFWKSVatRVPKE 249
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvLYTLKEV--KIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082   250 PPEIRILNPYFIQEAAFTLIGLPFNNglmgrGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIK 329
Cdd:pfam00777 160 PDKVLFLHPDFLRYVANFWLRSHGLK-----GRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGG 234

                         250       260
                  ....*....|....*....|..
gi 28373082   330 ESWTHNIQREKEFLRKLVKARV 351
Cdd:pfam00777 235 FYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 140-346 5.55e-165

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 459.00  E-value: 5.55e-165
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 140 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 219
Cdd:cd23981   1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYEKDSLFVLAGFKWQD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 220 FKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCD 299
Cdd:cd23981  81 FKWLKYIVYKEKVSASDGFWKSVATRVPREPHEIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTLGSVAITMALHNCD 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 28373082 300 EVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 346
Cdd:cd23981 161 EVAVAGFGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 140-346 1.23e-128

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 367.00  E-value: 1.23e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 140 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQD 219
Cdd:cd23967   1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYDSDWLLVLVPFKSMD 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 220 FKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNglMGRGNIPTLGSVAVTMALHGCD 299
Cdd:cd23967  81 LLWLQAVIKGKKPNGKGGFWKKIATSVPKPPKKIRILNPYILQEAAFDLIGLPMNG--KQGKNVPTTGIIAIVMALHYCD 158

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 28373082 300 EVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 346
Cdd:cd23967 159 EVDIAGFGYDPSDPNAPLHYYDSLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 141-346 1.42e-88

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 265.45  E-value: 1.42e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 220
Cdd:cd23983   2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDPTSLFVAVLFKSVDF 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 221 KWLKYIVYKERVSASDG--FWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGL--PFNNGLMGRGNIPTLGSVAVTMALH 296
Cdd:cd23983  82 AWLKAMVKKEPLSFWSRlfFWKEVADSIPLKPSQFRILNPLIIKETALDILQYpePQSRLWGWDKNVPTLGVTAVVLATH 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 28373082 297 GCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 346
Cdd:cd23983 162 LCDEVSLAGFGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 100-351 2.39e-87

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 263.70  E-value: 2.39e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082   100 KWARIREFVPPFgiKGQDNLIKAILSVTKeyrltpaLDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGF 179
Cdd:pfam00777  11 EWIRYSEWWLPF--TVTEELLELLPKVSP-------FDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGY 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082   180 EKDVGSKTTLRITYPEGAMQR-------PEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSAS---DGFWKSVatRVPKE 249
Cdd:pfam00777  82 EKDVGSKTTLRTMNPESAIDSkygnlgfSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSlrvLYTLKEV--KIPVD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082   250 PPEIRILNPYFIQEAAFTLIGLPFNNglmgrGNIPTLGSVAVTMALHGCDEVAVAGFGYDMSTPNAPLHYYETVRMAAIK 329
Cdd:pfam00777 160 PDKVLFLHPDFLRYVANFWLRSHGLK-----GRRPSTGLLMLSLALHLCDEVSLYGFGPFLDSRGNSHHYYDNVLMKKGG 234

                         250       260
                  ....*....|....*....|..
gi 28373082   330 ESWTHNIQREKEFLRKLVKARV 351
Cdd:pfam00777 235 FYGVHDMPFEFKLLQKLHKEGV 256
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 141-346 1.13e-76

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 234.64  E-value: 1.13e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 220
Cdd:cd23984   2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHYDPNTTVVLIPFKPHDL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 221 KWLKYIVYKERVSASdGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDE 300
Cdd:cd23984  82 RWLLDLLMGKKVSAK-GFWKKPALNLIYKPNQIRILNPFILRIAAYELLHFPKRFPKEKKPKHPTTGIIAITLALHICNE 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 28373082 301 VAVAGFGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEFLRKL 346
Cdd:cd23984 161 VHIAGFKYDFSNLNSTLHYYGNETMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 140-346 1.31e-73

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 226.85  E-value: 1.31e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 140 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRP-EQYERDSLFVLAGFKWQ 218
Cdd:cd23982   1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFYPESAQFDPgIENDPDTLLVLVPFKPL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 219 DFKWLKYIVYKERVSAsDGFWKSVATRVPKEPPEIRILNPYFIQEAAFTLIGLPfnnGLMGRGNIPTLGSVAVTMALHGC 298
Cdd:cd23982  81 DFYWLYEILSNEKRVR-KGFWKQPPRIWDANPKQIRILNPYYTYVAATKLLQVP---GQRKKKQKPTTGLLAITLALHLC 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 28373082 299 DEVAVAGFGY-DMSTPNAPLHYYETVRMAAIKESwTHNIQREKEFLRKL 346
Cdd:cd23982 157 DEVHIAGFGYpDNGNSNQPIHYYNQITLKSMANS-GHNLNAEAQAIQRL 204
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 144-346 3.28e-52

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 171.39  E-value: 3.28e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 144 CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQR---------PEQYERDSLFVLAG 214
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYlrgprcgchPLPLEEEVVLILSR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 215 FKWQDFKWLKYIVYkervsasdgfwksvatRVPKEPPEIRILNPYFIQEAAFTLIGLpfNNGLMGRGNIPTLGSVAVTMA 294
Cdd:cd19952  81 AAAADFKRLKRRKK----------------RHDNAVLLLTDPAPDLLSYVRKRLEKL--GLKSFFGGNAPSSGLLAVLLA 142

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 28373082 295 LHGCDEVAVAGFGYDMS-TPNAPLHYYETVRMAAikESWTHNIQREKEFLRKL 346
Cdd:cd19952 143 LQLCDSVDLYGFGVDSGhAPKVPYHYYDLVEAEE--GTAVHSFDLEAELLRAL 193
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 91-353 2.90e-43

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 151.64  E-value: 2.90e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082  91 PMFLDDS---FRKWARIREFVPPFGIKGQD-NLIKAILSVTK----EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRI 162
Cdd:cd23964  24 KVLLDSEdfnPEEYNRLSHYKLPFGWGGLNrEVVERLLRNLNltssRYMFVLRGGRPRCIRCAVVGNGGILNGSGKGKEI 103

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 163 DDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPE---GAMQRPEQYERDSLFVLAGFKWQDFKWLKYIVYKERVSASDGFW 239
Cdd:cd23964 104 DAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPEslhNSLLKHVPQDKDTKYLFIPFKIRDYDYLDAVLSGKPVPDGCDKG 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 240 KSV-ATRVPKEPPE-IRILNPYFIQEAaftliglpFNNGL-MGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmstPNAP 316
Cdd:cd23964 184 KRPpPLFGPKLNATnVRLLHPDFIRYL--------FNRWLnSSTSYRPTTGALMLLTALHTCDQVSVYGFGYD---PRFS 252

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 28373082 317 LHYYETVRMAAIKESWTHNIQREKEFLRKLVKARVIT 353
Cdd:cd23964 253 LHYYDKTFVKFTVFYANHDFTNERKLWRKLHEEGIIN 289
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 140-353 2.76e-40

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 143.19  E-value: 2.76e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 140 RCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAM-QRPEQYerdslFVLAGFKWQ 218
Cdd:cd23966  76 RCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESAVdLDPGVH-----LVLVPFKVL 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 219 DFKWLKyivykervSA-SDGFWKSVATRVPK----EPPEIRILNPYFIQEAAFTLIGlpfnnglmGRGNIPTLGSVAVTM 293
Cdd:cd23966 151 DLQWLI--------SAlTTGEITRTYTPVKRfikaDKDKVLVINPAFIKYVHDNWTE--------HHGRYPSTGFLALIF 214

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28373082 294 ALHGCDEVAVAGFGYDmSTPNAPlHYYETVRmAAIKESWT--HNIQREKEFLRKLVKARVIT 353
Cdd:cd23966 215 ALHICDEVSVFGFGAD-SKGNWH-HYWEKNR-SAGAFRKTgvHDADFESDIIKKLAKEGKIR 273
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 95-321 1.12e-29

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 114.98  E-value: 1.12e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082  95 DDSFRKWARIREFVPPfgiKGQDNLIKAILSVTK-EYRLTPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNS 173
Cdd:cd23980  37 EDTYKWWLRLQREKKP---KNLNDTIRELFQVVPgNVDPLLEKRLVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNK 113

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 174 APVKGFEKDVGSKTTLRITYPEGAMQRPEQYErdslFVLAGFKWQDFKWLKYIVYKERVSASdgfWKSVATRVPKEPPEI 253
Cdd:cd23980 114 APTEGFEADVGSKTTHHFVYPESFRELAQNVS----MILVPFKTLDLEWVISATTTGTISHT---YVPVPRKIKVKKEKI 186

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28373082 254 RILNPYFIQEAaftliglpFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFGYDmSTPNAPlHYYE 321
Cdd:cd23980 187 LIYHPAFIKYV--------FDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYGFGAD-SKGNWH-HYWE 244
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 137-352 4.99e-27

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 108.03  E-value: 4.99e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 137 DSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYErdslFVLAGFK 216
Cdd:cd23979  76 DPSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVS----FVLVPFK 151

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 217 WQDFKWLKYIVYKERVSASDGFWKSVaTRVPKEppEIRILNPYFiqeaaFTLIglpFNNGLMGRGNIPTLGSVAVTMALH 296
Cdd:cd23979 152 TLDLLWITSALSTGQIRFTYAPVKQF-LRVDKD--KVQIYNPAF-----FKYI---HDRWTEHHGRYPSTGMLVLFFALH 220

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 28373082 297 GCDEVAVAGFGYDmSTPNAPlHYYETVRMAA-IKESWTHNIQREKEFLRKLVKARVI 352
Cdd:cd23979 221 VCDEVNVYGFGAD-SRGNWH-HYWENNRYAGeFRKTGVHDADFEAHIIDMLAKAGKI 275
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 142-346 2.78e-23

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 97.34  E-value: 2.78e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 142 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEgAMQRPEQ-------YERDSLFV--- 211
Cdd:cd23968  46 NTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQ-ILSKPEFnfltdplYRNVTLLVwdp 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 212 -------LAGFKWQDFKWL-KYIVYKErvsasdgfwksvatRVPKEPPEirILNPYF-------IQEAAFTliglpfnng 276
Cdd:cd23968 125 ssynvnlEKWYKKPDFDFFpNYIKYRR--------------RHPEEPFY--LIDPRFlwrlwdiLQEYTPE--------- 179

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 28373082 277 lMGRGNIPTLGSVAVTMALHGCDEVAVagFGYDMSTPNAPL-HYYETVRMAAIKESWTHNIQREKEFLRKL 346
Cdd:cd23968 180 -KIKPNPPSSGFIGIVLMLHLCDWVDV--YEYVPSVRQTDRcHYYDVEKDLACTLGAWHPLAAEKLLVRHL 247
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 92-352 3.14e-22

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 95.20  E-value: 3.14e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082  92 MFLDD---SFRKWARIREFVPPFGIKGQD-NLIKAILSV---TKEYRLTPAL--DSLRCRRCIIVGNGGVLANKSLGSRI 162
Cdd:cd23973  25 LFLDKdhfNMSEWDRLEHFNPPFGFMGLNyTLVKEVVELipkPKEQQLLALSppGGDGCIRCAVVGNGGILNGSKMGQEI 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 163 DDYDIVVRLNSAPVKGFEKDVGSKT------------TLRITYPEGAMQRPEQYERDSLFVLAGFKwqDFKWLKYIVYKE 230
Cdd:cd23973 105 DSHDYVFRVNGAVIKGYEEDVGTRTsfyvhtahsitsSLMILQKRGFKNIPQDKDIKYILFPEGPR--DYQWLEALLKNK 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 231 RVsaSDGFWKSvatRVPKE-------PPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAV 303
Cdd:cd23973 183 TI--PSGAYYG---RRPRSyfsgdftEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTTGAFLLLTALHLCDTVSA 257

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 28373082 304 AGF---GYDmstpNAPLHYYETvrmaaikeSWT-------HNIQREKEFLRKLVKARVI 352
Cdd:cd23973 258 YGFiteDYR----KYPDHYYDK--------KKTklvfyinHDFRLEKKLWKRLHDEKII 304
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 142-346 6.35e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 88.09  E-value: 6.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 142 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTL------RITYPEGAMQRPEQYERdslFVlagf 215
Cdd:cd23963  64 KTCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNLttlnpsILKRRYNSLKKNRDRDK---FL---- 136

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 216 kwQDFKWLK--YIVY-KERVSASDGFWKSVATRVPKEPPEIRIL--NP-YFIQEAAFtliglpfnNGLMGRGNIPTLGSV 289
Cdd:cd23963 137 --NRLKEYNgsILWYpKFSFKSSTNLLLKAARALKKNGLNLTVVysNPeHFLAVQKF--------WKRRGLEKRPSTGLY 206

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 290 AVTMALHGCDEVAVAGF---GYDMSTPNAPLHYYEtvRMAAIKESWTHNIQREKEFLRKL 346
Cdd:cd23963 207 LVSLALTFCDEIHLYGFwpfPTDPNGRPVPYHYYD--DLSPSTKNKVHNMPEEFKLLREL 264
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 101-352 1.27e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 87.96  E-value: 1.27e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 101 WARIREFVPPFGIKG-QDNLIKAILSV---TKEYRLTPALDS-LRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAP 175
Cdd:cd23972  37 WDRLSQRKVPYGWKGlSHQVVASTLSLlndSANAKLFFPRDTpGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAV 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 176 VKGFEKDVGSKTTLR-----------ITYPEGAMQRPEQyERDSLFVLAGFKWQDFKWLKYIVYKERV-SASDGFWKSVA 243
Cdd:cd23972 117 IKGFEEDVGTKTSFYgftvntmknslISYWNLGFTRTPQ-GQDLQYIFIPSDIRDYVMLRSAILGVPVpEGLDKGDRPHK 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 244 TRVPKEPPE-IRILNPYFIQEAAFTLIGLPFNNGLMGRGNIPTLGSVAVTMALHGCDEVAVAGFgydmSTPNAPL---HY 319
Cdd:cd23972 196 YFGPEASAKkFKLLHPDFISYLTDRFLKSKLLNTHYGHLYMPSTGALMLLTALHTCDQVSAYGF----ITSNYWKfsdHY 271

                       250       260       270
                ....*....|....*....|....*....|...
gi 28373082 320 YETVRMAAIKESwTHNIQREKEFLRKLVKARVI 352
Cdd:cd23972 272 YERKKKPLVFYA-NHDMLLEAALWRRLHKAGIL 303
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 141-322 1.66e-19

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 86.14  E-value: 1.66e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI----TYPEGAMQRPEQYERDS---LFVLa 213
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVvshsSLPRLLRNAILLLAGTRaptVVVF- 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 214 gfkwqdfkWLKYIVYKERVSASDGFWKSVATRVPKeppeiriLNPYFiqeaaftliglpFNNGLMGRGN--------IPT 285
Cdd:cd23965  80 --------WGPETKMNKDGAGKYNLLRSLSKKYPD-------VEFYS------------LTPEKMDYADelfeketgKSR 132

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 28373082 286 LGS--------VAVTMALHGCDEVAVagfgYDMSTPN---------APLHYYET 322
Cdd:cd23965 133 IKSgtwlstgwFTMLLALDVCDEIKV----YGMVPENycrehpnskVPYHYYEP 182
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 141-353 2.54e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 81.34  E-value: 2.54e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLFVLAGFKWQDF 220
Cdd:cd23974  84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAGVGFNGPPQSKETRY 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 221 KWL-----KYIVYKERVSasdgfwKSVATRVP---KEPP----------EIRILNPYFIQEAAFTLIGLPFNNGLMGRGN 282
Cdd:cd23974 164 IFLpdhdrDYLLVKAALT------HTPIDRGRdksKRPSkyfgkdvtaeKFKIYHPDFIRYLRNRFLWSPILNTKQRDIY 237

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 28373082 283 IPTLGSVAVTMALHGCDEVAVAGFgydmSTPNAPL---HYYETVRMAAIKESwTHNIQREKEFLRKLVKARVIT 353
Cdd:cd23974 238 RPSTGAVMLLAALHTCDQVSAYGF----MTPDYGKysdHYYDKTYHKVVFYA-NHDLRLEMQLWQKLHKAGLIK 306
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 142-348 3.38e-15

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 74.87  E-value: 3.38e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 142 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEGAMQRPEQYERDSLF---VL-----A 213
Cdd:cd23986  50 RSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIDSSLYkdvILvawdpA 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 214 GFKWQDFKWLK---------YIVYKErvsasdgfwksvatRVPKEPpeIRILNPYF-------IQEaaftliglpfNNGL 277
Cdd:cd23986 130 PYSANLHKWYKkpdynlftpYVQYRK--------------RNPNQP--FYILHPKFiwqlwdiIQE----------NTQE 183

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 28373082 278 MGRGNIPTLGSVAVTMALHGCDEVAVagFGYDMSTPNAPL-HYYETVRMAAIKESWTHNIQREKEFLRKLVK 348
Cdd:cd23986 184 KIQPNPPSSGFIGILIMMSMCREVHV--YEYIPSVRQTDLcHYHERYYDAACTLGAYHPLLYEKLLIQRMNK 253
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 141-325 4.17e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 73.74  E-value: 4.17e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI----TYPEGAMQRPE--QYERDSLFVLAG 214
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVvshtSVPLLLRNQGYffQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 215 FKWQDFKWLKYIVYKervsasdgfwksVATRVPKEPPEIRIlnpYFIQEAAFTLIGLPFNN----GLMGRGNIPTLGSVA 290
Cdd:cd23977  81 PERNMDRDGGGKTYR------------ALLTLAKMYPHLQV---YTLTEEKMAYCDGVFQNetgkNRMKSGSFLSTGWFT 145

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 28373082 291 VTMALHGCDEVAVAG-----FGYDMSTPNAPLHYYETVRM 325
Cdd:cd23977 146 MILALELCEEILVYGmvsdsYCRNKNHSSVPYHYYEKGRL 185
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 130-346 1.12e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 73.43  E-value: 1.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 130 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI--------------- 191
Cdd:cd23987  50 YELLPRTSPLKNKHfktCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTmnpsvvqrafedlvn 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 192 -TYPEGAMQRPEQYERDSLFV---LAGFKWQDFKWLKYIVYKERVSASDGFwksvatrvpkepPEIRILNP---YFIQea 264
Cdd:cd23987 130 eTWKEKFLQRLQSLNGSILWIpafMAKGGEERVEWVNDLILKHHINVRTAY------------PSLRLLHAvrgYWLT-- 195

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 265 aftliglpfNNGLMGRgniPTLGSVAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKE 341
Cdd:cd23987 196 ---------NKVHIKR---PTTGLLMYTLATRFCNRIHLYGfwpFPRDQNQNPVKYHYYDSLKYGYTSQASPHTMPLEFK 263


                ....*
gi 28373082 342 FLRKL 346
Cdd:cd23987 264 ALKNL 268
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 142-346 1.28e-14

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 72.82  E-value: 1.28e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 142 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPEgAMQRPE-QYERDSLF---VL----- 212
Cdd:cd23985  46 GRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ-LVTTEKhKFLKDSLYnegILivwdp 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 213 AGFKWQDFKWLKYIVYK--ERvsasdgfWKSVATRVPKEPpeIRILNPYF-------IQEAAFTLIGL-PFNNGLMGrgn 282
Cdd:cd23985 125 APYHSDIPEWYKNPDYNffEN-------YKTYRRLNPNQP--FYILHPQMqwelwdiIQENSPEEIQPnPPSSGMLG--- 192

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 28373082 283 iptlgsVAVTMALhgCDEVAVAGFgydmsTPNAP----LHYYETVRMAAIKESWTHNIQREKEFLRKL 346
Cdd:cd23985 193 ------IILMMTL--CDQVDVYEF-----LPSKRktdvCHYYQKFFDRACTMGAYHPLLYEKNLVKHL 247
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 130-352 1.78e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 72.81  E-value: 1.78e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 130 YRLTPA---LDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLrITYPEGAMQRpeQYER 206
Cdd:cd23970  54 RSLLPEvspFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNL-TTFNPSILEK--YYNN 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 207 dsLFVLagfkwQDFKwlkyiVYKERVSASDG--FWKSVATRvPKEPPEIRILNPYFIQEAAFTLIGLPFNNGLMGRGN-- 282
Cdd:cd23970 131 --LLTI-----QDRN-----NFFLSLKKLDGaiLWIPAFFF-HTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNry 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 283 ----------IPTlGSVAVTMALHGCDEVAVAGF---GYDMSTPNAPLHYYETVRMA-AIKESWTHNIQREKEFLRKLVK 348
Cdd:cd23970 198 wktkhlspkrLST-GILMYTLASAICEEIHLYGFwpfGFDPTGTPLPYHYYDKKGTKfTTKWQESHQLPAEFVLLYKMHG 276


                ....
gi 28373082 349 ARVI 352
Cdd:cd23970 277 AGVL 280
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 133-346 2.68e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 69.37  E-value: 2.68e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 133 TPALDSLRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPE------GAMQRPEQYER 206
Cdd:cd23969  56 VSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSviphayGDLVNATDKEK 135

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 207 ---------DSLFVLAGF--KW--QDFKWLKYIVYKERVSASDGFwksvatrvpkepPEIRILNpyfiqeaafTLIGLPF 273
Cdd:cd23969 136 fverlrqlgDSILWIPAFvsKGgeEHVQWTNEIILKHKLNVKTAY------------PPLRLNH---------AIRGYWL 194

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 28373082 274 NNGLmgRGNIPTLGSVAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAikESWTHNIQREKEFLRKL 346
Cdd:cd23969 195 TTKF--RIKRPSTGLLMYTLATRFCDEIHLYGfypFSEDGNGRAVKYHYYDNRKYLT--TARPHKMPEEFRALRSL 266
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 143-324 8.04e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 64.97  E-value: 8.04e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 143 RCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKgFEKDVGSKTTL--------RITYPEGAMQRPEQYER-----DSL 209
Cdd:cd23971  66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNLvtanpsilREKFHNLKKRRRPFVERmkvygNAL 144

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 210 FVLAGFKW--------------QDFKWLKYIVY--KERVSASDGFWKSVATRvpkeppEIRIlnpyfiqeaaftliglpf 273
Cdd:cd23971 145 LLLPAFSYtsntepslralytlEDFGSPQKVLFfnPEYLRNLSRYWKSKGLK------ARRL------------------ 200

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 28373082 274 NNGLMgrgniptlgsvAVTMALHGCDEVAVAGF---GYDMSTPNAPLHYYETVR 324
Cdd:cd23971 201 STGLM-----------LVSAALELCENVHLYGFwpfSTDLDGNPISHHYYDNVL 243
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 130-346 1.07e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 64.59  E-value: 1.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 130 YRLTPALDSLRCRR---CIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITYPE------GAMQR 200
Cdd:cd23988  50 HSLLPEVSPMKNRRfktCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSvvqrafGGFRN 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 201 PEQYER---------DSLFVLAGFK----WQDFKWLKYIVYKERVSASDGFwksvatrvpkepPEIRILNpyfiqeaafT 267
Cdd:cd23988 130 ESDREKfvhrlsmlnDSVLWIPAFMvkggEKHVEWVNALILKNKLKVRTAY------------PSLRLIH---------A 188

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 268 LIGLPFNNGLmgrgNI--PTLGSVAVTMALHGCDEVAVAG---FGYDMSTPNAPLHYYETVRMAAIKESWTHNIQREKEF 342
Cdd:cd23988 189 VRGYWLTNKV----NIkrPSTGLLMYTLATRFCDEIHLYGfwpFPKDANGNPVKYHYYDDLKYRYFSNAGPHRMPLEFKT 264


                ....
gi 28373082 343 LRKL 346
Cdd:cd23988 265 LNVL 268
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 121-189 1.75e-11

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 64.00  E-value: 1.75e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 28373082 121 KAILSVTKEYRLTPALDSLRCR---RCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKG-FEKDVGSKTTL 189
Cdd:cd23991  41 KKILITENIFRMFPKSQPFRGYpykQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL 113
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 139-321 1.26e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 61.04  E-value: 1.26e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 139 LRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRITyPEGAMQR--PEQYE-----RDSLFV 211
Cdd:cd23976  13 MHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVI-AHSSIQRilRNRNEllnvsQGTVFI 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 212 LAG---FKWQDFKWLKY----------------IVYKERVSASDGFWKsvatrvpKEPPEIRILNPYFIQEAAFTLiglp 272
Cdd:cd23976  92 FWGpsnYMRRDGKGLVYnnlqlmnqilpklkvyTITRHKMLQFDELFK-------RETGKDRKISNTWLSTGWFTM---- 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 28373082 273 fnnglmgrgniptlgsvavTMALHGCDEVAVAG-----FGYDMSTPNAPLHYYE 321
Cdd:cd23976 161 -------------------IIALELCDRINVYGmvppdFCRDPNHPSVPYHYYE 195
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 141-324 1.26e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 60.72  E-value: 1.26e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI---TYPEGAMQRPEQYERD---SLFVLag 214
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVvshTSVPLLLKNPDYFFKEtneTIYVI-- 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 215 fkWQDFKWLK-----------------------YIVYKERVSASDGFWKsvatrvpKEPPEIRILNPYFIQEAAFTLIgl 271
Cdd:cd23975  79 --WGPFRNMRkdgkgivynmlkkavesypqakiYVTTEKRMSYCDTVFK-------KETGKDRVQSGSYLSTGWFTLI-- 147

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 28373082 272 pfnnglmgrgniptlgsvavtMALHGCDEVAVAGFGYDMSTPN-----APLHYYETVR 324
Cdd:cd23975 148 ---------------------LAMDACYGIHVYGMINDTYCKTegyrkVPYHYYEPGR 184
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 141-191 2.30e-10

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 59.87  E-value: 2.30e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 28373082 141 CRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPVKGFEKDVGSKTTLRI 191
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRV 51
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 139-323 1.50e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 55.22  E-value: 1.50e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 139 LRCRRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPV-KGFEKDVGSKTTLRITYPEGAMQRPEQ--YERDSLfvLAGF 215
Cdd:cd23989  61 LPLKKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPLsREYTDDVGTKTQLVTANPSIIDKRFQNllWSRKSF--VESM 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 216 KWQDFKWLKYIVYKERVSASDGFWKSVATRVPKEPPEIRILNPYFIQEaaftlIGLPFNNGLMGRGNIPTlGSVAVTMAL 295
Cdd:cd23989 139 KVYGRSYIYMPAFSMKTGTDPSLRVYYTLADVGANQTVLFANPNFLRN-----VGKFWKSKGVHAKRLST-GLFLVSAAL 212

                       170       180       190
                ....*....|....*....|....*....|.
gi 28373082 296 HGCDEVAVAGF-GYDMSTPNAPL--HYYETV 323
Cdd:cd23989 213 GLCEEVTIYGFwPFSVDLDERTIshHYYDNV 243
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 142-324 1.07e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 52.53  E-value: 1.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 142 RRCIIVGNGGVLANKSLGSRIDDYDIVVRLNSAPV-KGFEKDVGSKTTLRITYPEGAMQRPEQYErdslfvlagfKWQDF 220
Cdd:cd23990  65 KKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPIsEKYVRDVGVKTDVVTINPSIITERFHKLE----------KWRRP 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28373082 221 KWLKYIVYKERVSASDGFWKS----VATRVP------KEPPEIRILNP-YFIQEAAFTLiglpfNNGLmgRGNIPTLGSV 289
Cdd:cd23990 135 FYEVLQVYENASVVLPAFYNTrntdVSIRVKyvlddfESQQAVYYFHPqYLLNVSRFWL-----RQGV--RAKRISSGLM 207

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 28373082 290 AVTMALHGCDEVAVAGF-GYDMSTPNAPL--HYYETVR 324
Cdd:cd23990 208 LVTAALELCEEVHLYGFwAFPMNPSGIFIthHYYDNVK 245
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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