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Conserved domains on  [gi|227330593|ref|NP_780347|]
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dynein axonemal intermediate chain 1 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-612 4.51e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 4.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 354 GSYDfmkqsrGMLLLYSMKNPSFPEYMFSSESGIMCLDVHVDHPYLVVvGYYDGNVAIYNLKKPHSQPCFRStsksgkHT 433
Cdd:cd00200   69 GSSD------KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSS-SSRDKTIKVWDVETGKCLTTLRG------HT 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 434 DPVWQVKWQKDDMdhnlnF-FSVSSDGRIVSWTLVKSELVHIdiiklktegstteipegLQLHTvGCGTAFDFHKEiDYM 512
Cdd:cd00200  136 DWVNSVAFSPDGT-----FvASSSQDGTIKLWDLRTGKCVAT-----------------LTGHT-GEVNSVAFSPD-GEK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 513 FLVGTEEGKIyKCSKSYSSQFLDTYDAHNMAVDAVLWNPyHTKVFMSCSSDWTVKIWDHTIKTPMFIYDL-NSAVGDVAW 591
Cdd:cd00200  192 LLSSSSDGTI-KLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAW 269

                        250       260
                 ....*....|....*....|.
gi 227330593 592 APySSTVFAAVTTDGKAHVFD 612
Cdd:cd00200  270 SP-DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-612 4.51e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 4.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 354 GSYDfmkqsrGMLLLYSMKNPSFPEYMFSSESGIMCLDVHVDHPYLVVvGYYDGNVAIYNLKKPHSQPCFRStsksgkHT 433
Cdd:cd00200   69 GSSD------KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSS-SSRDKTIKVWDVETGKCLTTLRG------HT 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 434 DPVWQVKWQKDDMdhnlnF-FSVSSDGRIVSWTLVKSELVHIdiiklktegstteipegLQLHTvGCGTAFDFHKEiDYM 512
Cdd:cd00200  136 DWVNSVAFSPDGT-----FvASSSQDGTIKLWDLRTGKCVAT-----------------LTGHT-GEVNSVAFSPD-GEK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 513 FLVGTEEGKIyKCSKSYSSQFLDTYDAHNMAVDAVLWNPyHTKVFMSCSSDWTVKIWDHTIKTPMFIYDL-NSAVGDVAW 591
Cdd:cd00200  192 LLSSSSDGTI-KLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAW 269

                        250       260
                 ....*....|....*....|.
gi 227330593 592 APySSTVFAAVTTDGKAHVFD 612
Cdd:cd00200  270 SP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
399-614 7.13e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 7.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 399 LVVVGYYDGNVAIYNLKKPHSQPCFRstsksgKHTDPVWQVKWQKDdmdhNLNFFSVSSDGRIVSWTLVKSELVHIdiik 478
Cdd:COG2319   92 LLASASADGTVRLWDLATGLLLRTLT------GHTGAVRSVAFSPD----GKTLASGSADGTVRLWDLATGKLLRT---- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 479 lkTEGSTTEI------PEGLQLHTVGC-GTAfdfhkeidymflvgteegKIYKCSksySSQFLDTYDAHNMAVDAVLWNP 551
Cdd:COG2319  158 --LTGHSGAVtsvafsPDGKLLASGSDdGTV------------------RLWDLA---TGKLLRTLTGHTGAVRSVAFSP 214

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 227330593 552 yHTKVFMSCSSDWTVKIWDhtIKTPMFIYDLN---SAVGDVAWAPYSSTVfAAVTTDGKAHVFDLA 614
Cdd:COG2319  215 -DGKLLASGSADGTVRLWD--LATGKLLRTLTghsGSVRSVAFSPDGRLL-ASGSADGTVRLWDLA 276
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 530-570 1.92e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.92e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 227330593   530 SSQFLDTYDAHNMAVDAVLWNPyHTKVFMSCSSDWTVKIWD 570
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
531-570 1.94e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.94e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 227330593  531 SQFLDTYDAHNMAVDAVLWNPyHTKVFMSCSSDWTVKIWD 570
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 354-612 4.51e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 4.51e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 354 GSYDfmkqsrGMLLLYSMKNPSFPEYMFSSESGIMCLDVHVDHPYLVVvGYYDGNVAIYNLKKPHSQPCFRStsksgkHT 433
Cdd:cd00200   69 GSSD------KTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSS-SSRDKTIKVWDVETGKCLTTLRG------HT 135

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 434 DPVWQVKWQKDDMdhnlnF-FSVSSDGRIVSWTLVKSELVHIdiiklktegstteipegLQLHTvGCGTAFDFHKEiDYM 512
Cdd:cd00200  136 DWVNSVAFSPDGT-----FvASSSQDGTIKLWDLRTGKCVAT-----------------LTGHT-GEVNSVAFSPD-GEK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 513 FLVGTEEGKIyKCSKSYSSQFLDTYDAHNMAVDAVLWNPyHTKVFMSCSSDWTVKIWDHTIKTPMFIYDL-NSAVGDVAW 591
Cdd:cd00200  192 LLSSSSDGTI-KLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGhTNSVTSLAW 269

                        250       260
                 ....*....|....*....|.
gi 227330593 592 APySSTVFAAVTTDGKAHVFD 612
Cdd:cd00200  270 SP-DGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 382-657 3.60e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.60  E-value: 3.60e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 382 SSESGIMCLDVHVDHPYLvVVGYYDGNVAIYNLKKPHSQPCFRStsksgkHTDPVWQVKWqkddMDHNLNFFSVSSDGRI 461
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLL-ATGSGDGTIKVWDLETGELLRTLKG------HTGPVRDVAA----SADGTYLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 462 VSWTLVKSELVHIdiiklktegstteipegLQLHTVGCgTAFDFHKEiDYMFLVGTEEGKIyKCSKSYSSQFLDTYDAHN 541
Cdd:cd00200   76 RLWDLETGECVRT-----------------LTGHTSYV-SSVAFSPD-GRILSSSSRDKTI-KVWDVETGKCLTTLRGHT 135

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 542 MAVDAVLWNPYHTKVFmSCSSDWTVKIWD-HTIKTPMFIYDLNSAVGDVAWAPySSTVFAAVTTDGKAHVFDLAVNKYEA 620
Cdd:cd00200  136 DWVNSVAFSPDGTFVA-SSSQDGTIKLWDlRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLG 213

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 227330593 621 ICNqpvvaKKKNKITHVQFNPIHPIIIVGDDRGHIIC 657
Cdd:cd00200  214 TLR-----GHENGVNSVAFSPDGYLLASGSEDGTIRV 245
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 492-655 2.77e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 2.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 492 LQLHTVGCgTAFDFHKEIDYMfLVGTEEGKIYKCSKSySSQFLDTYDAHNMAVDAVLWNPYHTKVFmSCSSDWTVKIWDh 571
Cdd:cd00200    5 LKGHTGGV-TCVAFSPDGKLL-ATGSGDGTIKVWDLE-TGELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTIRLWD- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 572 tIKTPMFIYDL---NSAVGDVAWAPySSTVFAAVTTDGKAHVFDLAVNKYEAICNQpvvakKKNKITHVQFNPIHPIIIV 648
Cdd:cd00200   80 -LETGECVRTLtghTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRG-----HTDWVNSVAFSPDGTFVAS 152


                 ....*..
gi 227330593 649 GDDRGHI 655
Cdd:cd00200  153 SSQDGTI 159
WD40 COG2319
WD40 repeat [General function prediction only];
399-614 7.13e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.75  E-value: 7.13e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 399 LVVVGYYDGNVAIYNLKKPHSQPCFRstsksgKHTDPVWQVKWQKDdmdhNLNFFSVSSDGRIVSWTLVKSELVHIdiik 478
Cdd:COG2319   92 LLASASADGTVRLWDLATGLLLRTLT------GHTGAVRSVAFSPD----GKTLASGSADGTVRLWDLATGKLLRT---- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 479 lkTEGSTTEI------PEGLQLHTVGC-GTAfdfhkeidymflvgteegKIYKCSksySSQFLDTYDAHNMAVDAVLWNP 551
Cdd:COG2319  158 --LTGHSGAVtsvafsPDGKLLASGSDdGTV------------------RLWDLA---TGKLLRTLTGHTGAVRSVAFSP 214

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 227330593 552 yHTKVFMSCSSDWTVKIWDhtIKTPMFIYDLN---SAVGDVAWAPYSSTVfAAVTTDGKAHVFDLA 614
Cdd:COG2319  215 -DGKLLASGSADGTVRLWD--LATGKLLRTLTghsGSVRSVAFSPDGRLL-ASGSADGTVRLWDLA 276
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 530-570 1.92e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 1.92e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 227330593   530 SSQFLDTYDAHNMAVDAVLWNPyHTKVFMSCSSDWTVKIWD 570
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
399-614 2.98e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 2.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 399 LVVVGYYDGNVAIYNLKkphSQPCFRSTSKsgkHTDPVWQVKWqkdDMDHNLnFFSVSSDGRIVSWTLVKSELVHIdiik 478
Cdd:COG2319  176 LLASGSDDGTVRLWDLA---TGKLLRTLTG---HTGAVRSVAF---SPDGKL-LASGSADGTVRLWDLATGKLLRT---- 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 479 lktegstteipegLQLHTvGCGTAFDFHKEiDYMFLVGTEEGKIYKCSKSySSQFLDTYDAHNMAVDAVLWNPyHTKVFM 558
Cdd:COG2319  242 -------------LTGHS-GSVRSVAFSPD-GRLLASGSADGTVRLWDLA-TGELLRTLTGHSGGVNSVAFSP-DGKLLA 304

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 227330593 559 SCSSDWTVKIWD-HTIKTPMFIYDLNSAVGDVAWAPYSSTVfAAVTTDGKAHVFDLA 614
Cdd:COG2319  305 SGSDDGTVRLWDlATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLA 360
WD40 pfam00400
WD domain, G-beta repeat;
531-570 1.94e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 1.94e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 227330593  531 SQFLDTYDAHNMAVDAVLWNPyHTKVFMSCSSDWTVKIWD 570
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
530-655 3.74e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 3.74e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 530 SSQFLDTYDAHNMAVDAVLWNPyHTKVFMSCSSDWTVKIWDhtIKTPMFIYDLN---SAVGDVAWAPySSTVFAAVTTDG 606
Cdd:COG2319  109 TGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWD--LATGKLLRTLTghsGAVTSVAFSP-DGKLLASGSDDG 184

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 227330593 607 KAHVFDLAVNKYEAicnqpVVAKKKNKITHVQFNPIHPIIIVGDDRGHI 655
Cdd:COG2319  185 TVRLWDLATGKLLR-----TLTGHTGAVRSVAFSPDGKLLASGSADGTV 228
WD40 COG2319
WD40 repeat [General function prediction only];
530-614 6.90e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 39.51  E-value: 6.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 227330593 530 SSQFLDTYDAHNMAVDAVLWNPyHTKVFMSCSSDWTVKIWD-HTIKTPMFIYDLNSAVGDVAWAPySSTVFAAVTTDGKA 608
Cdd:COG2319   67 AGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDlATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTV 144


                 ....*.
gi 227330593 609 HVFDLA 614
Cdd:COG2319  145 RLWDLA 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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