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Conserved domains on  [gi|28892715|ref|NP_795894|]
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leucine-rich repeat and transmembrane domain-containing protein 1 precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12183770)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Homo sapiens leucine-rich repeat-containing protein 38 that is auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha)

Gene Ontology:  GO:0005515
PubMed:  14747988|11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
45-201 3.01e-09

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 3.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28892715  45 SVDCSGQGLSKVPRDLPPWT--VTLLLQDNRIHWLPalafqsvsllstlnlsnnslsnlaaEAFYGLPHLRVLNVTQNSL 122
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLP-------------------------EPLGNLTNLKSLDLSNNQL 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28892715 123 LSIESSFAHaLPGLRELDLSSNSLRILPTSLGKpWENLTVFAVQQNHLLHLDRElLEAMPKVRLVLLKDN-----PWICD 197
Cdd:COG4886 172 TDLPEELGN-LTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNqltdlPELGN 248


                ....
gi 28892715 198 CHLL 201
Cdd:COG4886 249 LTNL 252
LRRCT super family cl47026
Leucine rich repeat C-terminal domain;
192-239 9.93e-04

Leucine rich repeat C-terminal domain;


The actual alignment was detected with superfamily member smart00082:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 9.93e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 28892715    192 NPWICDCHLLGLKLWLERFTFQGGETDgAICRLPEPWQGKALLSIPHE 239
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLRGPLLELLHSE 47
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-201 3.01e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 3.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28892715  45 SVDCSGQGLSKVPRDLPPWT--VTLLLQDNRIHWLPalafqsvsllstlnlsnnslsnlaaEAFYGLPHLRVLNVTQNSL 122
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLP-------------------------EPLGNLTNLKSLDLSNNQL 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28892715 123 LSIESSFAHaLPGLRELDLSSNSLRILPTSLGKpWENLTVFAVQQNHLLHLDRElLEAMPKVRLVLLKDN-----PWICD 197
Cdd:COG4886 172 TDLPEELGN-LTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNqltdlPELGN 248


                ....
gi 28892715 198 CHLL 201
Cdd:COG4886 249 LTNL 252
LRR_8 pfam13855
Leucine rich repeat;
104-146 8.27e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 8.27e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 28892715   104 EAFYGLPHLRVLNVTQNSLLSIES-SFAHaLPGLRELDLSSNSL 146
Cdd:pfam13855  19 GAFKGLSNLKVLDLSNNLLTTLSPgAFSG-LPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-62 2.74e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.76  E-value: 2.74e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 28892715     33 CPMKCLCHPSSnsVDCSGQGLSKVPRDLPP 62
Cdd:smart00013   2 CPAPCNCSGTA--VDCSGRGLTEVPLDLPP 29
LRRCT smart00082
Leucine rich repeat C-terminal domain;
192-239 9.93e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 9.93e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 28892715    192 NPWICDCHLLGLKLWLERFTFQGGETDgAICRLPEPWQGKALLSIPHE 239
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLRGPLLELLHSE 47
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-181 2.32e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 40.07  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28892715   41 PSS-NSVDCSGQGLSKVPRDLPPWTVTLLLQDNRIHWLPAlafqsvsllstLNLSNNSLSNLAAEAFYGLP-----HLRV 114
Cdd:PRK15370 261 PSAlQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPA-----------HLPSGITHLNVQSNSLTALPetlppGLKT 329

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28892715  115 LNVTQNSLLSIESSFAhalPGLRELDLSSNSLRILPTSLgKPweNLTVFAVQQNHLLHLDRELLEAM 181
Cdd:PRK15370 330 LEAGENALTSLPASLP---PELQVLDVSKNQITVLPETL-PP--TITTLDVSRNALTNLPENLPAAL 390
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-201 3.01e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 58.02  E-value: 3.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28892715  45 SVDCSGQGLSKVPRDLPPWT--VTLLLQDNRIHWLPalafqsvsllstlnlsnnslsnlaaEAFYGLPHLRVLNVTQNSL 122
Cdd:COG4886 117 SLDLSGNQLTDLPEELANLTnlKELDLSNNQLTDLP-------------------------EPLGNLTNLKSLDLSNNQL 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28892715 123 LSIESSFAHaLPGLRELDLSSNSLRILPTSLGKpWENLTVFAVQQNHLLHLDRElLEAMPKVRLVLLKDN-----PWICD 197
Cdd:COG4886 172 TDLPEELGN-LTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNqltdlPELGN 248


                ....
gi 28892715 198 CHLL 201
Cdd:COG4886 249 LTNL 252
LRR_8 pfam13855
Leucine rich repeat;
104-146 8.27e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 8.27e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 28892715   104 EAFYGLPHLRVLNVTQNSLLSIES-SFAHaLPGLRELDLSSNSL 146
Cdd:pfam13855  19 GAFKGLSNLKVLDLSNNLLTTLSPgAFSG-LPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
110-149 5.77e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 5.77e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 28892715   110 PHLRVLNVTQNSLLSIESSFAHALPGLRELDLSSNSLRIL 149
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTL 40
LRRNT smart00013
Leucine rich repeat N-terminal domain;
33-62 2.74e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 40.76  E-value: 2.74e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 28892715     33 CPMKCLCHPSSnsVDCSGQGLSKVPRDLPP 62
Cdd:smart00013   2 CPAPCNCSGTA--VDCSGRGLTEVPLDLPP 29
LRR_8 pfam13855
Leucine rich repeat;
134-193 2.40e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.66  E-value: 2.40e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 28892715   134 PGLRELDLSSNSLRILPTSLGKPWENLTVFAVQQNHLLHLDRELLEAMPKVRLVLLKDNP 193
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 33-61 4.87e-04

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 36.84  E-value: 4.87e-04
                          10        20
                  ....*....|....*....|....*....
gi 28892715    33 CPMKCLCHPSSnsVDCSGQGLSKVPRDLP 61
Cdd:pfam01462   2 CPVPCHCSATV--VNCSDRGLTAVPRDLP 28
LRRCT smart00082
Leucine rich repeat C-terminal domain;
192-239 9.93e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 36.64  E-value: 9.93e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 28892715    192 NPWICDCHLLGLKLWLERFTFQGGETDgAICRLPEPWQGKALLSIPHE 239
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEHLQDPVD-LRCASPSSLRGPLLELLHSE 47
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
41-181 2.32e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 40.07  E-value: 2.32e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28892715   41 PSS-NSVDCSGQGLSKVPRDLPPWTVTLLLQDNRIHWLPAlafqsvsllstLNLSNNSLSNLAAEAFYGLP-----HLRV 114
Cdd:PRK15370 261 PSAlQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTLPA-----------HLPSGITHLNVQSNSLTALPetlppGLKT 329

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28892715  115 LNVTQNSLLSIESSFAhalPGLRELDLSSNSLRILPTSLgKPweNLTVFAVQQNHLLHLDRELLEAM 181
Cdd:PRK15370 330 LEAGENALTSLPASLP---PELQVLDVSKNQITVLPETL-PP--TITTLDVSRNALTNLPENLPAAL 390
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
44-192 7.16e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 37.99  E-value: 7.16e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28892715  44 NSVDCSGQGLSKVPRDLPPWTVTLLLQDNRIHWLPALAFQSVSLLSTLNLSNNSLSNLAAEAFYGLPHLRVLNVTQNSLL 123
Cdd:COG4886  30 LLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEEL 109

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 28892715 124 SiessfahALPGLRELDLSSNSLRILPTSLGKpWENLTVFAVQQNHLLHLDRElLEAMPKVRLVLLKDN 192
Cdd:COG4886 110 S-------NLTNLESLDLSGNQLTDLPEELAN-LTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNN 169
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 110-144 8.24e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 33.76  E-value: 8.24e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 28892715   110 PHLRVLNVTQNSLLSIESSfaHALPGLRELDLSSN 144
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPL--AKLPNLETLDLSGN 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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