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Conserved domains on  [gi|2315457141|ref|NP_803434|]
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solute carrier organic anion transporter family member 3A1 [Rattus norvegicus]

Protein Classification

solute carrier organic anion transporter( domain architecture ID 13024459)

solute carrier organic anion transporter is a major facilitator superfamily (MFS) transporter that mediates the Na(+)-independent high affinity transport of organic anions such as pravastatin, taurocholate, methotrexate, dehydroepiandrosterone sulfate, prostaglandin E2, thromboxane B2, leukotriene C3, and the thyroid hormones thyroxine and triiodothyronine, among others

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
39-563 0e+00

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 845.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  39 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17402     1 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLTHQYKyeageirwgaegrdvcatngsssdegpdpdlicrnrtaTNMMYLLLIGAQVLLGIGATPVQPLG 198
Cdd:cd17402    81 GALLSALPEFLTHQYK--------------------------------------TNMMYLLLIGAQVLLGIGATPVQPLG 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 199 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFS 278
Cdd:cd17402   123 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWGGFLLCGALLFFS 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 279 SLLMFGFPQSLpphsepgmeseqamlpereyerpkpsngvlrhplepdssascfQQLRVIPKVTKHLLSNPVFTCIVLAA 358
Cdd:cd17402   203 ALLMFGFPQSL-------------------------------------------QQLRVIPKVTKHLLSNPVFTCIVLAA 239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 359 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 438
Cdd:cd17402   240 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 439 LFLGCDTGPVAGVTVRYGNNSARGSPLDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPPE 518
Cdd:cd17402   320 LFLGCDTGPVAGVTVPYGNDTAPGSSLDPYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSGCACLSSVPAE 399
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 2315457141 519 NATVVPGKCPSPGCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17402   400 NATVVPGKCPSPGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
 
Name Accession Description Interval E-value
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
39-563 0e+00

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 845.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  39 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17402     1 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLTHQYKyeageirwgaegrdvcatngsssdegpdpdlicrnrtaTNMMYLLLIGAQVLLGIGATPVQPLG 198
Cdd:cd17402    81 GALLSALPEFLTHQYK--------------------------------------TNMMYLLLIGAQVLLGIGATPVQPLG 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 199 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFS 278
Cdd:cd17402   123 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWGGFLLCGALLFFS 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 279 SLLMFGFPQSLpphsepgmeseqamlpereyerpkpsngvlrhplepdssascfQQLRVIPKVTKHLLSNPVFTCIVLAA 358
Cdd:cd17402   203 ALLMFGFPQSL-------------------------------------------QQLRVIPKVTKHLLSNPVFTCIVLAA 239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 359 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 438
Cdd:cd17402   240 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 439 LFLGCDTGPVAGVTVRYGNNSARGSPLDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPPE 518
Cdd:cd17402   320 LFLGCDTGPVAGVTVPYGNDTAPGSSLDPYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSGCACLSSVPAE 399
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 2315457141 519 NATVVPGKCPSPGCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17402   400 NATVVPGKCPSPGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
41-619 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 427161 [Multi-domain]  Cd Length: 526  Bit Score: 604.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  41 IFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGA 120
Cdd:pfam03137   1 GFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLILFVSYFGGKGHRPRWIGVGSLLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 121 LLSALPEFLThqykyeageirwgaegrdvcatngsssdegpdpdlicrnrtatnmmyllLIGAQVLLGIGATPVQPLGVS 200
Cdd:pfam03137  81 LLFALPHFLS-------------------------------------------------FFLGQLLLGIGGTPLYTLGIS 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 201 YIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDavfIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSL 280
Cdd:pfam03137 112 YIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVD---IGSVSLTLTPKDPRWVGAWWLGFLIAGLLLLLTAI 188
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 281 LMFGFPQSLPphsepGMESEQAMlpereyeRPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIVLAACM 360
Cdd:pfam03137 189 PFFFFPKSLP-----GTAKRRAE-------KKKEPESHSIKDSEKTKSLKLGKSLKDFPRALKRLLKNPVYMLLTLASVS 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 361 EIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLF 440
Cdd:pfam03137 257 EFLLIAGYATFLPKYIETQFGLSASTANLLTGVVLIPGAALGILLGGLIIKKFKLSAKGLAKFNLITSLVSLLLSLLLFF 336
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 441 LGCDTGPVAGVTVRYGNNSARGSPLDpySPCNNNCECQTDSFTPVCGADGITYLSACFAGC-----------NSTNLTGC 509
Cdd:pfam03137 337 LGCPNSPVAGITVPYGGTQQLSGNLT--ASCNSNCSCSTSFYSPVCGSDGIGYTSPCPCGAgcssssgagksTYNCSCCC 414
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 510 ACLTTVPPENATVVPGKCPSPgCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPP 589
Cdd:pfam03137 415 SCGSSTSGGNGSATPGKCPSD-CSNKLPLFLALLFLASFFSSLSSTPGTLIILRCVPPEDKSFALGLQFLILRLLGFIPG 493
                         570       580       590
                  ....*....|....*....|....*....|
gi 2315457141 590 PLIFGAGIDSTCLFWSTFCGEQGACVLYDN 619
Cdd:pfam03137 494 PIIFGALIDSTCLLWTKTCGGRGNCWLYDN 523
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
34-650 1.03e-152

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 456.50  E-value: 1.03e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  34 SCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGG 113
Cdd:TIGR00805  26 SLFSKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGC 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 114 IVMALGALLSALPEFLTHQYKYEAGEIRWG---AEGRDVCATNGSSSDEGPDPDLICRNRTATNMMYLLLIGaQVLLGIG 190
Cdd:TIGR00805 106 AIMGLGSLLSSLPHFLMGRYSYSTTVSSTGnlsSANSFLCMENLTQTLRPTQDPSECQKQHKSLMWLLFLVS-NILRGIG 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 191 ATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLL 270
Cdd:TIGR00805 185 ATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWIGFLV 264
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 271 CGALLFFSSLLMFGFPQSLPPHS--EPGMESEQAMLPEREYERPKPSNGVLRHplepdssascfqqlrvIPKVTKHLLSN 348
Cdd:TIGR00805 265 CGFVALLTSIPLFFFPKTLPKEGkrVNVDVHEAEKLEKSRGEDRKKNSGITKD----------------FPKFIKRLLCN 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 349 PVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVN 428
Cdd:TIGR00805 329 KIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLS 408
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 429 LVSTACYVSFLFLGCDTGPVAGVtvrygNNSARGSPLDPYSP--CNNNCECQTDSFTPVCGADGITYLSACFAGCNST-- 504
Cdd:TIGR00805 409 TLEYLLYSPKFLITCESAPVAGV-----NNPSNDQPLYVENRtdCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSvg 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 505 -----NLTGCACLTTvpPENATVVPGKCPSPgCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIRTVSPELKSYALGVLFL 579
Cdd:TIGR00805 484 tgsnmVFTNCSCIQT--PGNSSAKKGLCDPP-CATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWF 560
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2315457141 580 LLRLLGFIPPPLIFGAGIDSTCLFWSTFC-GEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRK 650
Cdd:TIGR00805 561 CIRVFGTIPAPILFGALIDVTCLHWQTLKcGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
471-503 2.40e-03

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 36.12  E-value: 2.40e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2315457141  471 CNNNCecqTDSFTPVCGADGITYLSACF---AGCNS 503
Cdd:smart00280   2 CPEAC---PREYDPVCGSDGVTYSNECHlckAACES 34
 
Name Accession Description Interval E-value
MFS_SLCO3_OATP3 cd17402
Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of ...
39-563 0e+00

Solute carrier organic anion transporter 3 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 3 (SLCO3) or Organic anion transporting polypeptide 3 (OATP3) family contains only one subfamily, OATP3A, which contains only one mammalian member OATP3A1 (encoded by SLCO3A1). It mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate, prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123, and vasopressin. SLCO3A1 has been identified as a Crohn's disease (CD)-associated gene, which mediates inflammatory processes in intestinal epithelial cells through NF-kappaB transcription activation, resulting in a higher incidence of bowel perforation in CD patients. The SLCO3/OATP3 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340960 [Multi-domain]  Cd Length: 444  Bit Score: 845.75  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  39 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17402     1 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLTHQYKyeageirwgaegrdvcatngsssdegpdpdlicrnrtaTNMMYLLLIGAQVLLGIGATPVQPLG 198
Cdd:cd17402    81 GALLSALPEFLTHQYK--------------------------------------TNMMYLLLIGAQVLLGIGATPVQPLG 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 199 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFS 278
Cdd:cd17402   123 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSKLDITPDDPRWIGAWWGGFLLCGALLFFS 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 279 SLLMFGFPQSLpphsepgmeseqamlpereyerpkpsngvlrhplepdssascfQQLRVIPKVTKHLLSNPVFTCIVLAA 358
Cdd:cd17402   203 ALLMFGFPQSL-------------------------------------------QQLRVIPKVTKHLLSNPVFTCIVLAA 239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 359 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 438
Cdd:cd17402   240 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 439 LFLGCDTGPVAGVTVRYGNNSARGSPLDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPPE 518
Cdd:cd17402   320 LFLGCDTGPVAGVTVPYGNDTAPGSSLDPYAPCNSNCECQTDSFSPVCGADGITYLSACFAGCSSTNLSGCACLSSVPAE 399
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*
gi 2315457141 519 NATVVPGKCPSPGCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17402   400 NATVVPGKCPSPGCQEAFLTFLCVMCVCSMIGAMAQTPSVIILIR 444
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
41-619 0e+00

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 427161 [Multi-domain]  Cd Length: 526  Bit Score: 604.20  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  41 IFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGA 120
Cdd:pfam03137   1 GFLVFLSLLGLAQALVSGYFNSSITTIEKRFGLPSSLSGLISSSYDIGNLLLILFVSYFGGKGHRPRWIGVGSLLMGLGS 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 121 LLSALPEFLThqykyeageirwgaegrdvcatngsssdegpdpdlicrnrtatnmmyllLIGAQVLLGIGATPVQPLGVS 200
Cdd:pfam03137  81 LLFALPHFLS-------------------------------------------------FFLGQLLLGIGGTPLYTLGIS 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 201 YIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDavfIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSL 280
Cdd:pfam03137 112 YIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVD---IGSVSLTLTPKDPRWVGAWWLGFLIAGLLLLLTAI 188
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 281 LMFGFPQSLPphsepGMESEQAMlpereyeRPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIVLAACM 360
Cdd:pfam03137 189 PFFFFPKSLP-----GTAKRRAE-------KKKEPESHSIKDSEKTKSLKLGKSLKDFPRALKRLLKNPVYMLLTLASVS 256
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 361 EIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFLF 440
Cdd:pfam03137 257 EFLLIAGYATFLPKYIETQFGLSASTANLLTGVVLIPGAALGILLGGLIIKKFKLSAKGLAKFNLITSLVSLLLSLLLFF 336
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 441 LGCDTGPVAGVTVRYGNNSARGSPLDpySPCNNNCECQTDSFTPVCGADGITYLSACFAGC-----------NSTNLTGC 509
Cdd:pfam03137 337 LGCPNSPVAGITVPYGGTQQLSGNLT--ASCNSNCSCSTSFYSPVCGSDGIGYTSPCPCGAgcssssgagksTYNCSCCC 414
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 510 ACLTTVPPENATVVPGKCPSPgCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPP 589
Cdd:pfam03137 415 SCGSSTSGGNGSATPGKCPSD-CSNKLPLFLALLFLASFFSSLSSTPGTLIILRCVPPEDKSFALGLQFLILRLLGFIPG 493
                         570       580       590
                  ....*....|....*....|....*....|
gi 2315457141 590 PLIFGAGIDSTCLFWSTFCGEQGACVLYDN 619
Cdd:pfam03137 494 PIIFGALIDSTCLLWTKTCGGRGNCWLYDN 523
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
39-563 7.52e-153

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 449.00  E-value: 7.52e-153
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  39 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17336     1 PKVFVVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLthqykyeageirwgaegrdvcatngsssdegpdpdlicrnrtatnmmylllIGAQVLLGIGATPVQPLG 198
Cdd:cd17336    81 GCFLLALPHFL---------------------------------------------------FVGQFLLGIGSSPLYTLG 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 199 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSnldITPDDPRWIGAWWGGFLLCGALLFFS 278
Cdd:cd17336   110 ITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRIYVDFSRVPLG---ITPDDPRWIGAWWLGFLILGILLLIV 186
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 279 SLLMFGFPqslpphsepgmeseqamlpereyerpkpsngvlrhplepdssascfqqlrvipkvtkhllsnPVFTCIVLAA 358
Cdd:cd17336   187 SIPLFFFP--------------------------------------------------------------PIFILLLLAI 204
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 359 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 438
Cdd:cd17336   205 VFESFAISGFSTFLPKYLETQFRLSASLASLLTGLILVPGAALGILLGGLIIKKFKLTARGLAKFVLILSLLSVILYISL 284
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 439 LFLGCDTGPVAGVTVRYGNnsargSPLDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGC-------NSTNLTGCAC 511
Cdd:cd17336   285 FFLGCDNPPIAGVTTPYGS-----SSSPITSSCNSDCNCSDSSFSPVCGSDGITYFSPCHAGCtssdagnGTKTYSNCSC 359
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2315457141 512 LTTVPPENATVVPGKCPSPGCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17336   360 INSGTATSSGCPPDCSVAPNCCSKLIPFLAVLFLSSFLLSLSIVPSTMITLR 411
oat TIGR00805
sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2. ...
34-650 1.03e-152

sodium-independent organic anion transporter; The Organo Anion Transporter (OAT) Family (TC 2.A.60)Proteins of the OAT family catalyze the Na+-independent facilitated transport of organic anions such as bromosulfobromophthalein and prostaglandins as well as conjugated and unconjugated bile acids (taurocholate and cholate, respectively). These transporters have been characterized in mammals, but homologues are present in C. elegans and A. thaliana. Some of the mammalian proteins exhibit a high degree of tissue specificity. For example, the rat OAT is found at high levels in liver and kidney and at lower levels in other tissues. These proteins possess 10-12 putative a-helical transmembrane spanners. They may catalyze electrogenic anion uniport or anion exchange.


Pssm-ID: 273279 [Multi-domain]  Cd Length: 632  Bit Score: 456.50  E-value: 1.03e-152
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  34 SCFSNIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGG 113
Cdd:TIGR00805  26 SLFSKIKMFSLLLTCARLQGLLVNGLVNSMLTSIERRFKIPTSRSGFINGSYEIGNLLLIIFVSYFGTKLHRPIVIGAGC 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 114 IVMALGALLSALPEFLTHQYKYEAGEIRWG---AEGRDVCATNGSSSDEGPDPDLICRNRTATNMMYLLLIGaQVLLGIG 190
Cdd:TIGR00805 106 AIMGLGSLLSSLPHFLMGRYSYSTTVSSTGnlsSANSFLCMENLTQTLRPTQDPSECQKQHKSLMWLLFLVS-NILRGIG 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 191 ATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLL 270
Cdd:TIGR00805 185 ATPIFPLGISYIDDFAKSKNSPLYIGILESGSVFGPAFGFLLGSFCLQIYVDTGSVNTEDLIITPTDPRWIGAWWIGFLV 264
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 271 CGALLFFSSLLMFGFPQSLPPHS--EPGMESEQAMLPEREYERPKPSNGVLRHplepdssascfqqlrvIPKVTKHLLSN 348
Cdd:TIGR00805 265 CGFVALLTSIPLFFFPKTLPKEGkrVNVDVHEAEKLEKSRGEDRKKNSGITKD----------------FPKFIKRLLCN 328
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 349 PVFTCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVN 428
Cdd:TIGR00805 329 KIYMLVILAQVIDVLAFNGYITFLPKYLENQYGISSAEANLLIGVVNVPPIGLGYLIGGFIMKKFKLNVKKAAYFAICLS 408
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 429 LVSTACYVSFLFLGCDTGPVAGVtvrygNNSARGSPLDPYSP--CNNNCECQTDSFTPVCGADGITYLSACFAGCNST-- 504
Cdd:TIGR00805 409 TLEYLLYSPKFLITCESAPVAGV-----NNPSNDQPLYVENRtdCNRQCSCDSSIWDPVCGDNGLAYLSPCHAGCRMSvg 483
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 505 -----NLTGCACLTTvpPENATVVPGKCPSPgCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIRTVSPELKSYALGVLFL 579
Cdd:TIGR00805 484 tgsnmVFTNCSCIQT--PGNSSAKKGLCDPP-CATSLQYFLILFIPLSFIYFITAVPGYMVLLRCVKSEERSLGLGLQWF 560
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2315457141 580 LLRLLGFIPPPLIFGAGIDSTCLFWSTFC-GEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRK 650
Cdd:TIGR00805 561 CIRVFGTIPAPILFGALIDVTCLHWQTLKcGASGACRMYDNDNLRVIYLGLTIALRGSSLLPLFFILILARK 632
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
40-563 7.36e-133

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 398.26  E-value: 7.36e-133
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  40 KIFLVSECALMLAQGT-VGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17404     1 KAFLVCMCLLIFIQSAlSSGYLNSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLthqykyeageirwgaegrdvcatngsssdegpdpdlicrnrtatnmmylllIGAQVLLGIGATPVQPLG 198
Cdd:cd17404    81 GSFLFSLPHFF---------------------------------------------------ILAQILIGMGGTPIFTLG 109
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 199 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVfidTSNLDITPDDPRWIGAWWGGFLLCGALLFFS 278
Cdd:cd17404   110 TTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGGLLINFYVDPL---STPPDISPGDPRWIGAWWGGFLLCGIALLLV 186
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 279 SLLMFGFPQslpphsepgmeseqamlpereyerpkpsngvlrhplepdssascfqqlrvipkvtkhllsnPVFTCIVLAA 358
Cdd:cd17404   187 AFPFFTFPK-------------------------------------------------------------MTFLVVSLGY 205
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 359 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 438
Cdd:cd17404   206 CMELAIVSGFITFLPKYLETQFGIPASNANIFTGVIAVPGAGIGIVLGGYILKRFKLGPKGAAKLALICNFLSLLLFLTL 285
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 439 LFLGCDTGPVAGVTVRYGNNSARGSPL--DPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNS--------TNLTG 508
Cdd:cd17404   286 FFLGCESIKLAGITIPYTTGPSLSSTHgrNLTSECNVNCGCSINEYEPVCGSDGITYFSPCLAGCTSvgntstgiRNYTN 365
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 509 CACLTT-VPPENATVVPGKCPSPG----CQEAFLTFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17404   366 CACLQSrSSISPPTVGQGSQLQAGpcsrTCNTLIPFLILLFIVTLITACAQMPALMITLR 425
MFS_SLCO1A_OATP1A cd17458
Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of ...
39-564 6.44e-120

Solute carrier organic anion transporter 1A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1A (SLCO1A), also called Organic anion-transporting polypeptide 1A (OATP1A), subfamily is composed of one human member OATP1A2 (encoded by SLCO1A2) and several rodent proteins encoded by the Slco1a1, Slco1a3, Slco1a4, Slco1a5, and Slco1a6 genes. OATP1A2, also known as human OATP-A or OATP1, shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). It is expressed in the brain, kidney, intestine, liver, lung, testes, and the eye (ciliary body). The SLCO1A/OATP1A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341016 [Multi-domain]  Cd Length: 527  Bit Score: 368.41  E-value: 6.44e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  39 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17458     2 LKIFLLALSYAYVAKTLSGAYMNSMITQIERRFNIPSSLVGIINGSFEIGNLLVIAFVSYFGAKLHRPKVIGLGCLIMSL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLTHQYKYEAGEIRWGAEGRDV--CATNGSSSDEGPDPDLICrNRTATNMMYLLLIGAQVLLGIGATPVQP 196
Cdd:cd17458    82 GCFLASLPHFLMGRYEYESTVSTTSNSSSRVplCLANQSLSHNVTQLPSEC-EKESMSLMWIFVLVGNLLRGIGETPVMP 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 197 LGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLF 276
Cdd:cd17458   161 LGISYIDDFSKKENSPFYIGCLHTATIVGPLLGLLLASFCAQLYVDLGSVNADDLTITPTDIRWVGAWWLGFLICAGVNF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 277 FSSLLMFGFPQSLPPHSEpgmeseqamlpEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIVL 356
Cdd:cd17458   241 LAGLPFWFLPKSLPKEGE-----------ENETEPSKTLTVELEENKGQETKQEMYEIAKDFLPFLKSLFRNPIYMLFII 309
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 357 AACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYV 436
Cdd:cd17458   310 VTVLQFNAFSGMISFMPKYLEQQYGKSASDAIFLIGVYNLPIICLGYFFGGLYMKKFKINTYQAAHIGFWVSLLEYLLYF 389
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 437 SFLFLGCDTGPVAGVTVRYgnnsaRGSPLDPY------SPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTG-- 508
Cdd:cd17458   390 SAFWMGCDNSPVAGLTVSY-----EGIDQDSYyentllADCNRDCDCPLKVWDPVCGNNGLTYVSACLAGCKASVGTGkn 464
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2315457141 509 -----CACLTTVP-PENATVVPGKCP-SPGCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIRT 564
Cdd:cd17458   465 mvfqnCSCVAASGfPSQNSSAVGQCDkGETCDKMLQYFLILSLVCSFIFSLAAMPGYMVLIRS 527
MFS_SLCO2A_OATP2A cd17461
Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of ...
38-563 1.06e-119

Solute carrier organic anion transporter 2A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2A (SLCO2A), also called Organic anion-transporting polypeptide 2A (OATP2A), subfamily has one mammalian member, OATP2A1 (encoded by SLCO2A1), which is also called prostaglandin transporter. It is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Mutations in SLCO2A1 can cause primary hypertrophic osteoarthropathy (PHO), a rare multi-organic disease characterized by digital clubbing, pachydermia and periosteal reaction. The SLCO2A/OATP2A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341019 [Multi-domain]  Cd Length: 474  Bit Score: 366.05  E-value: 1.06e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  38 NIKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMA 117
Cdd:cd17461     1 NIKVFVLCHGLLQLSQLLYSAYFKSSLTTIEKRFGLSSLSSGLISSLHEIGNAVLIIFVSYFGSRVHRPRLIGIGGLLLA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 118 LGALLSALPEFLTHQYKYEageirwgaegrdvcatngsssdegpdpdlicrnrtatnmMYLLLIGAQVLLGIGATPVQPL 197
Cdd:cd17461    81 LGAFLLTLPHFLSEPYQYS---------------------------------------MWVLMVVAQLLAGIGTVPIQPF 121
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 198 GVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFF 277
Cdd:cd17461   122 GISYVDDFAEPSNSPLYIAILFAISVFGPAFGYLLGSVVLRIFVDIGRVNTATVELTPADPRWIGAWWLGLLISSGLLVL 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 278 SSLLMFGFPQSLPPHSEPGmeSEQAMLpeREYERPKPSNGvlrhplepdssaSCFQQLRVIPKVTKHLLSNPVFTCIVLA 357
Cdd:cd17461   202 TSLPYFFFPREMLVGKKPS--PEGDML--RKKEDEKKEEG------------SLLDFIKRFPKMFVKLLLNPLFMLLVLA 265
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 358 ACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVS 437
Cdd:cd17461   266 QCTFSSVIAGLSTFLNKFLEKQYGASASYANFLIGAVNLPAAALGMLLGGIIMKRFGFSLRAIPRFSVVILSISIMLCVP 345
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 438 FLFLGCDTGPVAGVTVRYGNNSArgsplDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLT---------- 507
Cdd:cd17461   346 LFFMGCSTQDVAGVYPKTSNSSD-----GPHLSCSANCSCPESAFNPVCGENGIEYISPCHAGCTNSNMDsstyrqqiys 420
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2315457141 508 GCACLTTVPPENaTVVPGKCPSPgCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17461   421 NCSCIPDLSGEK-PAKTGSCPNS-CSHLLLPVMFLISFAGLIACLTHNPLYMMVLR 474
MFS_SLCO1C_OATP1C cd17459
Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of ...
39-563 8.86e-119

Solute carrier organic anion transporter 1C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1C (SLCO1C), also called Organic anion-transporting polypeptide 1C (OATP1C), subfamily contains one mammalian member, OATP1C1 (encoded by SLCO1C1), which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine), as well as organic anions such as 17-beta-glucuronosyl estradiol, estrone-3-sulfate, and sulfobromophthalein (BSP), which are transported with much lower efficiency. The SLCO1C/OATP1C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341017 [Multi-domain]  Cd Length: 498  Bit Score: 364.47  E-value: 8.86e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  39 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17459     1 LKIFLAALSFAYFAKALSGSYMKSTITQIERRFDIPSSLIGVIDGSFEMGNLLVIAFVSYFGAKLHRPRIIGAGCLLMAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLTHQYKYEAGEIRWGAEGRDVCATNGSSSDEGPDPDLI-------CRNRTATNMMYLLLIGaQVLLGIGA 191
Cdd:cd17459    81 GTFLIALPHFFMGRYKYETAIQSSSNSTVSISPCSLEPSPQLHSIESSdsktgtgCEKEPGSSMWIYVFLG-NLLRGIGE 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 192 TPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLC 271
Cdd:cd17459   160 TPVQPLGISYIDDFAKEENAAFYIGCVQTIAIIGPVFGFLLGSLCAKLYVDIGFVNLDSITITPKDARWVGAWWLGYLIA 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 272 GALLFFSSLLMFGFPQSLPPHSEPGMeseqamlpereyerpkpsngvlrhplepdssascfqqlrvipkvtKHLLSNPVF 351
Cdd:cd17459   240 GVITLLSAVPFWFLPKSLPKDFLPSL---------------------------------------------KNLLGNPVY 274
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 352 TCIVLAACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVS 431
Cdd:cd17459   275 FLYLCTSILQFNSLIGMVTYKPKYIEQQYGQSASKANFLIGLINIPAVAIGIFSGGLLMKKFKLSVIGAAKLSFGTSFFG 354
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 432 TACYVSFLFLGCDTGPVAGVTVRY-GNNSARGSPLDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTG-- 508
Cdd:cd17459   355 YLLLLSFFAMGCENSDVAGLTVSYnGTKQVSYADRSLFSQCNADCKCSQKDWDPVCGENGITYVSPCLAGCKASNGSGkn 434
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2315457141 509 -----CACLTTVPPE--NATVVPGKCP-SPGCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17459   435 tvfhnCSCIGIPSSAsgSSSAILGQCPkGNACARMFLYFLAISVISSFTLSLGGTPGYILLIR 497
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
39-563 2.29e-118

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 362.93  E-value: 2.29e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  39 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17460     1 IKFFVLCHGLLQLSQLLVSGYLKSSISTIEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLTHQYKYeageirwgaegrdvcatngsssdegpdpdlicrnrtatnmmyLLLIGAQVLLGIGATPVQPLG 198
Cdd:cd17460    81 AGFLMALPHFISEPYEY------------------------------------------GILFLGQLLLGIGGVPIQPFG 118
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 199 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFS 278
Cdd:cd17460   119 ISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAMLRFYVDIDKMSEDEISLEIGDPRWVGAWWLGFLIAATLVALS 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 279 SLLMFGFPQSLPphsepgmeSEQAMLPEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIVLAA 358
Cdd:cd17460   199 AVPYFFFPREMP--------KEVVELQPREKKLAKTMLKKLKSLSDILQNLSLLQFIKKFPRILLRTLRNPIYLLVVLAQ 270
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 359 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 438
Cdd:cd17460   271 VNLSAMVAGLATFMGKFLERQFSITASFANLMIGGLNIPSAMVGIVVGGVILKRLQLTVRGCGAMCVLGMLLCLFFALPL 350
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 439 LFLGCDTGPVAGVTVRYgnNSARGSPLDPysPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNL----------TG 508
Cdd:cd17460   351 LFIGCSTQKIAGITHRT--SSSPGLELSS--QCSEACSCPPEAFNPVCGSDGVEYISPCHAGCKSVNVqaldnsvvnyTD 426
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 2315457141 509 CACLTTVPPENATvVPGKCPSpGCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17460   427 CSCVSEGGPVGAA-SPGTCGS-GCSHLLVPFMLLVSLGGFLASLSHTPSFMLILR 479
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
39-563 9.06e-115

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 351.17  E-value: 9.06e-115
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  39 IKIFLVSECALMLAQGTVGAYLVSV-LTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMA 117
Cdd:cd17403     1 PKGFLFFLCIFAFLQGMVVNGFVNVsITTIEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 118 LGALLSALPEFLthqykyeageirwgaegrdvcatngsssdegpdpdlicrnrtatnmmylLLIGAQVLLGIGATPVQPL 197
Cdd:cd17403    81 IGSLVFALPHFT-------------------------------------------------VFILAQLLHGAGATPLYTL 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 198 GVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDaVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFF 277
Cdd:cd17403   112 GVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTD-IDQVDSELGLTPDDPRWVGAWWLGFLISGALALI 190
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 278 SSLLMFGFPqslpphsepgmeseqamlpereyerpkpsngvlrhplepdssascfqqlrvipkvtkhllsnPVFTCIVLA 357
Cdd:cd17403   191 IAFPLLGFP--------------------------------------------------------------PTFMFLNLA 208
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 358 ACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACyVS 437
Cdd:cd17403   209 GASEGMLLAGFATFLPKLIESQFSLSASLAALLVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLF-SF 287
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 438 FLFLGCDTGPVAGVTVRYGNNSARGSPlDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGC-------NSTNLTGCA 510
Cdd:cd17403   288 ILLIYCPNAPFAGVTVPYGNSPLEGTS-NLTSTCNADCHCSEDFYDPVCGSDGVTYYSPCHAGCttshgddGQKVYSNCS 366
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2315457141 511 CL---TTVPPENATVVPGKCPSPgCQEAFLtFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17403   367 CIqsnSSKTSTAATGKACPCETC-CQKLYL-FLAVFFLLIVFTFMSSTPALSATLR 420
MFS_SLCO1B_OATP1B cd17457
Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of ...
39-563 1.20e-109

Solute carrier organic anion transporter 1B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1B (SLCO1B), also called organic anion-transporting polypeptide 1B (OATP1B), subfamily is composed of two human proteins, OATP1B1 (encoded by SLCO1B1) and OATP1B3 (encoded by SLCO1B3), and one rodent member, OATP1B2 (encoded by Slco1b2). OATP1B1 and OATP1B3 are almost exclusively expressed on the basal side of hepatocytes in normal human organs. They both can accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). Loss-of-function mutations in both SLCO1B1 and SLCO1B3 genes result in the Rotor syndrome, a hereditary hyperbilirubinemia. The SLCO1B/OATP1B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341015 [Multi-domain]  Cd Length: 455  Bit Score: 339.51  E-value: 1.20e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  39 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17457     1 LKMFLAALSFSYFAKALSGIIMKSSITQIERRFDISSSTVGFIDGSFEIGNLLVIAFVSYFGAKLHRPKLIAAGCFIMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLTHQYKYEageirwgaegrdvCATNGSSsdegpdpdlicrnrtatnMMYLLLIGAQVLLGIGATPVQPLG 198
Cdd:cd17457    81 GSVLTALPHFFMGYYKYG-------------CLKESGS------------------YMWVYVLMGNMLRGIGETPIVPLG 129
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 199 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFS 278
Cdd:cd17457   130 ISYLDDFAKEENSPLYLACLHTIAMIGPMIGFTLGSLFAKLYVDIGFVDLSTIRITPQDSRWVGAWWLGFLVSGLFSIIS 209
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 279 SLLMFGFPqslpphsepgmeseqamlpereyerpkpsngvlrhplepdssaSCFQQLrvipkvtKHLLSNPVFTCIVLAA 358
Cdd:cd17457   210 AIPFFFLP-------------------------------------------GFFQSL-------KSILTNRLYVMFVCLT 239
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 359 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 438
Cdd:cd17457   240 LLQVSSFIGFFTYKPKYMEQQYGQSSSKANFLLGVITLPIFASGMFLGGYIMKKYKLNTVGAAKFACFTSVMALSFYLLY 319
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 439 LFLGCDTGPVAGVTVRY-GNNSARGSPLDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTG-------CA 510
Cdd:cd17457   320 FFIGCENKSVAGITMTYdGNNPVTSHRDVILSYCNSDCNCDESQWDPVCGNNGITYISACLAGCKSSSGNGkpivfhnCS 399
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2315457141 511 CLTTVPPE--NATVVPGKCP-SPGCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17457   400 CLEVTGSQnrNYSAHLGECPrDDDCSRMFYFYVVIQVLNLFFSALGGTSAYMLIVK 455
MFS_SLCO2_OATP2 cd17401
Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of ...
39-563 4.82e-104

Solute carrier organic anion transporter 2 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2 (SLCO2) or Organic anion transporting polypeptide 2 (OATP2) family contains two subfamilies: OATP2A and OATP2B, each containing one mammalian member, OATP2A1 and OATP2B1, respectively. OATP2A1 (encoded by SLCO2A1) is a lactate/prostaglandin anion exchanger that mediates the release of newly synthesized prostaglandins (PGD2, PGE1, PGE2, PGF2A and PGI2) from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. OATP2B1 (encoded by SLCO2B1) mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost, as well as endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). The SLCO2/OATP2 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340959 [Multi-domain]  Cd Length: 440  Bit Score: 324.49  E-value: 4.82e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  39 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17401     1 IKVFVLCHGLLQLCQLLYSGYLKSSITTIEKRFGLSSSSSGLLASFNEVGNTILIVFVSYFGSRVHRPRLIGIGGLFLAA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLTHQYKYEageirwgaegrdvcatngsssdegpdpdlicrnrtatnmmylLLIGAQVLLGIGATPVQPLG 198
Cdd:cd17401    81 GAFLLTLPHFISEPYQYG------------------------------------------IMVVAQLLLGIGGVPIQPFG 118
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 199 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFS 278
Cdd:cd17401   119 ISYIDDFAEPSNSPLYLGILFAVTVFGPAFGYLLGSVMLRLYVDIGRMNTAAVNLVPGDPRWIGAWWLGFLIAAALLVLT 198
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 279 SLLMFGFPQSLpphsepgmeseqamlpereyerpkpsngvlrhplepdssascfqqlRVIPKVTKHLLSNPVFTCIVLAA 358
Cdd:cd17401   199 SFPYFFFPRFI----------------------------------------------KRFPCIFLRTLRNPIFLLVVLAQ 232
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 359 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 438
Cdd:cd17401   233 VTLSSMIAGLATFLNKFLEKQFGTTASYANFLIGAVNLPSAALGILFGGVLMKRLVLSLQAIPAICTTIITISMIFCVPL 312
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 439 LFLGCDTGPVAGVTvrYGNNSARGSPLDPysPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNL-----------T 507
Cdd:cd17401   313 FFIGCSTPTIAGVY--PPSSSSSIHPQSP--ACRRDCSCPDSIFNPVCGDNGVEYLSPCHAGCSNINMstsatskqviyT 388
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2315457141 508 GCACLTTVPPENATvvpGKCPSPgCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17401   389 NCSCVTGGSASAKT---GSCPSP-CSHLLLPFIFLISLVSLIACLSHTPSFMMILR 440
MFS_SLCO1_OATP1 cd17400
Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of ...
39-563 1.01e-101

Solute carrier organic anion transporter 1 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 1 (SLCO1) or Organic anion transporting polypeptide 1 (OATP1) family contains three subfamilies: OATP1A, OATP1B, and OATP1C. OATP1A contains one human member, OATP1A2, which shows a broad spectrum of substrates including endogenous compounds (such as bile acids, steroid hormones and their conjugates, thyroid hormones) and various drugs (such as fexofenadine, ouabain and the cyanobacterial toxin microcystin). OATP1B contains two human proteins, OATP1B1 and OATP1B3, which can both accept a wide variety of structurally-unrelated compounds as substrates including clinically-important drugs such as hydroxymethylglutaryl (HMG)-CoA reductase inhibitors (statins), angiotensin II receptor blockers (sartans), angiotensin converting enzyme (ACE) inhibitors, and anti-diabetes drugs (glinides). OATP1C contains one mammalian member, OATP1C1, which is also called thyroxine transporter. It mediates the high affinity transport of the thyroid hormones, T4 (3,5,3',5'tetraiodo-L-thyronine or thyroxine), rT3 (3,3'5'-triiodo-L-thyronine), and T3 (3,5,3'tri-iodo-L-thyronine or triiodothyronine). The SLCO1/OATP1 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340958 [Multi-domain]  Cd Length: 436  Bit Score: 318.32  E-value: 1.01e-101
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  39 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17400     1 LKMFLLALSCAFVAKTLSGSYMKSMITQIERRFNIPSSLVGFIDGSFEIGNLLVIIFVSYFGTKLHRPKMIGIGCVIMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLTHQYKYeageirwgaegrdvcatngsssdegpdpdlicrnrtatNMMYLLLIGAQVLLGIGATPVQPLG 198
Cdd:cd17400    81 GCFLKALPHFFMNQYEY--------------------------------------SLMWIYVFVGNILRGIGETPILPLG 122
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 199 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFS 278
Cdd:cd17400   123 ISYIDDFAKEENSPLYIGLVETGAIIGPIIGFLLGSLCAKVYVDIGFVNLDDIIITPTDTRWVGAWWLGFLICGGVSVLT 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 279 SLLMFGFPqslpphsepgmeseqamlpereyerpkpsngvlrhplepdssascfqqlrvipkvtkhllsnPVFTCIVLAA 358
Cdd:cd17400   203 AIPFFFLP--------------------------------------------------------------PIYMLFILVS 220
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 359 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 438
Cdd:cd17400   221 VIQFNSFVGMITYMPKYLEQQYGQSSSDANFLMGIINIPPIAIGYFIGGLIMKKFKITVKGAAKIGCWLSVLEYLLYLLS 300
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 439 LFLGCDTGPVAGVTVRY-GNNSARGSPLDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTG-------CA 510
Cdd:cd17400   301 FLMTCENSSVAGLTTSYeGIPPVLYHENDIFSDCNSDCNCPEKIWEPVCGNNGITYLSACLAGCETSIGTGknivfynCS 380
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2315457141 511 CLTTVPPENA--TVVPGKCP-SPGCQEAFLTFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17400   381 CIQTSGNSSAnlSLCDGGCPrDPDCSLMFQYFLIISVMSSFIYSLGGIPGYMLLLR 436
MFS_SLCO4C_OATP4C cd17463
Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of ...
40-563 6.95e-89

Solute carrier organic anion transporter 4C subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4C (SLCO4C), also called Organic anion-transporting polypeptide 4C (OATP4C), subfamily has one mammalian member, OATP4C1 (encoded by SLCO4C1). It is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. It is the only OATP expressed at the basolateral side of proximal tubular cells in human kidney and it mediates the excretion of uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs) and cause further progression of renal damage and cardiovascular diseases. Overexpression of human SLCO4C1 in rat kidney promotes the renal excretion of uremic toxins and reduces hypertension, cardiomegaly, and renal inflammation in renal failure. The SLCO4C/OATP4C subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341021 [Multi-domain]  Cd Length: 429  Bit Score: 284.33  E-value: 6.95e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  40 KIFLVSECALMLAQGTVGAYLVSV-LTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17463     2 KGYLLFYSLLAVVQGIVVNGLVNIsISTIEKRYELSSSLTGLISSSYDISFCLLSLFVSFYGERGHKPRWLAFSAFMIGL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLthqykyeageirwgaegrdvcatngsssdegpdpdlicrnrtatnmmylLLIGAQVLLGIGATPVQPLG 198
Cdd:cd17463    82 GSLVFSLPHFF-------------------------------------------------VFILGQLLLGVGGTPLYTLG 112
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 199 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAVFIdtSNLDITPDDPRWIGAWWGGFLLCGALLFFS 278
Cdd:cd17463   113 TAYIDDSVPTHKSSLYIGIGYGMSVLGPAIGYLLGGQLLNIYIDVNKG--QSVDLTEEDPRWLGAWWIGFLMCWLIAWCL 190
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 279 SLLMFGFPQSLPphsepgmeseqamlpereyerpkpsngvlrhplepdssascfqqlrvipkvtkHLLSNPVFTCIVLAA 358
Cdd:cd17463   191 IAPFSCFPKHLP-----------------------------------------------------GLLKNPVFMCLTISS 217
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 359 CMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSF 438
Cdd:cd17463   218 CSEALITTGFATFLPKFIENQFGQTSSFAAILGGLVLIPGAAIGQILGGIIVSKFKLKCKNMIKFAIITTTVSLLLLSVF 297
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 439 LFLGCDTGPVAGVTVRYgNNSARGSPLDpySPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLTG-------CAC 511
Cdd:cd17463   298 IFAKCGNDPFAGVSETY-NGTGKIGNLT--APCNANCSCLSSFYYPVCGADGVQYFSPCFAGCTNENLHDkkkvyynCSC 374
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 2315457141 512 LTTVPPENATVVpGKCPSPGCQEA----FLTFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17463   375 IGNFTEEFSANT-TKCEEGKKCETtcknLPIFLCFFFFVVIFTFMTSTPITVAILR 429
MFS_SLCO4A_OATP4A cd17462
Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of ...
47-552 1.02e-83

Solute carrier organic anion transporter 4A subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4A (SLCO4A), also called Organic anion-transporting polypeptide 4A (OATP4A), subfamily has one mammalian member, OATP4A1 (encoded by SLCO4A1). It is ubiquitously expressed and it mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4A1 is the most abundantly expressed transporter colorectal cancer (CRC) and its role in the transport of estrone sulfate, which is used in hormone replacement therapy (HRT), affects the outcome of the treatment. The SLCO4A/OATP4A subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341020 [Multi-domain]  Cd Length: 427  Bit Score: 270.94  E-value: 1.02e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  47 CALMLAQG-TVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSAL 125
Cdd:cd17462     9 CAASFLQGmTVNGFINTVITSIERRFDLRSYQSGLIASSYDIAACLCLTFVSYFGGSGHKPRWLGWGVLIMGLGSLVFAL 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 126 PEFlthqykyeageirwgaegrdvcatngsssdegpdpdlicrnrtaTNMMYllligAQVLLGIGATPVQPLGVSYIDDH 205
Cdd:cd17462    89 PHF--------------------------------------------TVFML-----GQFLHGIGATPLYTLGVTYLDEN 119
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 206 VRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVDAvfidTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGF 285
Cdd:cd17462   120 VKSNYSPVYIGIFYTAAIVGPAAGYLLGGFFLNIYTEI----GRQTELTPENPLWVGAWWIGFLGAGAAALLIALPILGY 195
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 286 PQSLPphsepgmeseqamlpereyerpkpsngvlrhplepdssascfqqlrvipkvtkHLLSNPVFTCIVLAACMEIAVV 365
Cdd:cd17462   196 PRQLP-----------------------------------------------------GLLKNPTFIFLCLAGATEATLI 222
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 366 AGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYVSFlFLGCDT 445
Cdd:cd17462   223 AGMSTFGPKFLESQFSLSASEAATLFGYLVVPAGGGGTFLGGFIVNKLKLRCSGIIKFCLICTVVSLLAIFIF-SLHCPN 301
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 446 GPVAGVTVRYGNNSARGSPLDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTNLT---------GCACLT-TV 515
Cdd:cd17462   302 VPMAGVTASYRGSVLPEGSLNLTALCNADCRCLEEIYSPVCGADGLMYYSPCHAGCSEAYSDirngqkvyqDCSCVAgNL 381
                         490       500       510
                  ....*....|....*....|....*....|....*....
gi 2315457141 516 PPENATVVPGKCPSPgCQE--AFLTFLCVMCVCSLIGAM 552
Cdd:cd17462   382 SVGFGEASAGKCTSN-CNHmpLLLAFVFLVILFTFLCSI 419
MFS_SLCO6_OATP6 cd17405
Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of ...
39-563 1.29e-43

Solute carrier organic anion transporter 6 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 6 (SLCO6) or Organic anion transporting polypeptide 6 (OATP6) family contains only one subfamily, OATP6A, which contains only one human member OATP6A1 (encoded by SLCO6A1). The OATP6 family is the most diverged of the OATPs. OATP6A1 is also called cancer/testis antigen 48 (CT48) or gonad-specific transporter. It is strongly expressed only in normal testis, and weakly in spleen, brain, fetal brain, and placenta. It is found in tumor samples (lung, bladder, and esophageal) and cancer cell lines (lung), and may be of potential use as a target for therapy for a variety of tumor types. The SLCO6/OATP6 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340963 [Multi-domain]  Cd Length: 428  Bit Score: 162.71  E-value: 1.29e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  39 IKIFLVSECALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMAL 118
Cdd:cd17405     1 IDGFMILYCILVLIQGAVFGLVDMSIGIFQVQFSLTRTEKYLLDFSYDISSFLVAIIIAHYGSRGNRTRWIAASCFLMGL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 119 GALLSALPEFLTHqykyeageirwgaegrdvcatngsssdegpdpdlicrnrtatnmmylllIGAQVLLGIGATPVQPLG 198
Cdd:cd17405    81 GSMLFAFPFFTFH-------------------------------------------------IAGQCIQGIAGMPIYILG 111
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 199 VSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKiyvdaVFIDTSNLDITPDD--PRWIGAWWGGFLLCGALLF 276
Cdd:cd17405   112 ITFIFDNIPTSSAGIYLGIAHSAYLIGYLLGYVGGLPNFQ-----PPPNEKSVEIEVNKvyQLWQSGWWKTFLIAAAIAW 186
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 277 FSSLLMFGFPQSLPphsepgmeseqamlpereyerpkpsngvlrhplepdssascfqqlrvipkvtkHLLSNPVFTCIVL 356
Cdd:cd17405   187 CTSFPLVCFPTSLP-----------------------------------------------------GLLKNPLLLCQAI 213
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 357 AACMEIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGAIRMAMLVNLVSTACYV 436
Cdd:cd17405   214 CKATEYLTFIGALEFLPHYLENQFLLTPGIASLLTGAFLIPGGAIGHFLGGLIVSRLEMSCKNKMRFILVTSVISLGLFV 293
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 437 SFLFLGCDTGPVAGVTVRYGNNSARGsplDPYSPCNNNCECQTDSFTPVCGADGITYLSACFAGCNSTN-------LTGC 509
Cdd:cd17405   294 LIFFVECQTVTFAGINEDYDGYGQLG---NLTAPCNEYCDCTSSLYTSICGRDEIEYFSPCFAGCKASKvsntektYYNC 370
                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 510 AC----LTTVPPENATV--VPGKCPSPgCQEAFLtFLCVMCVCSLIGAMAQTPSVIILIR 563
Cdd:cd17405   371 SCikegLAAADDEGDFIdaIAGKCDSK-CYKLPL-FFAFYFSATVFSNMCSIPIILIILR 428
KAZAL_SLC21 cd01330
The kazal-type serine protease inhibitor domain has been detected in an extracellular loop ...
467-511 4.93e-17

The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a member of the superfamily of kazal-like proteinase inhibitors and follistatin-like proteins.


Pssm-ID: 238650 [Multi-domain]  Cd Length: 54  Bit Score: 75.42  E-value: 4.93e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 2315457141 467 PYSPCNNNCECQTDSFTPVCGADGITYLSACFAGC-------NSTNLTGCAC 511
Cdd:cd01330     1 LTSSCNSNCSCSESAYSPVCGENGITYFSPCHAGCtnstgsgGSKIYTNCSC 52
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
47-456 3.89e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 77.47  E-value: 3.89e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  47 CALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALP 126
Cdd:cd06174     2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 127 EflthqykyeageirwgaegrdvcatngsssdegpdpdlicrnrtatnmMYLLLIGAQVLLGIGATPVQPLGVSYIDDHV 206
Cdd:cd06174    82 P------------------------------------------------SFWLLLLGRFLLGLGSGLIDPAVLALIADLF 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 207 RRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYVdavfidtsnlditpddprwiGAWWGGFLLCGALLFFSSLLMFGFP 286
Cdd:cd06174   114 PERERGRALGLLQAFGSVGGILGPLLGGILASSLG--------------------FGWRAVFLIAAALALLAAILLLLVV 173
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 287 QSLPPHSepgmeseqamlpereyerpkpsngvlRHPLEPDSSASCFQQLRVipkvtkhLLSNPVFTCIVLAACMEIAVVA 366
Cdd:cd06174   174 PDPPESA--------------------------RAKNEEASSKSVLKLLKR-------VLKNPGLWLLLLAIFLVNLAYY 220
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 367 GFAAFLGKYLEQQFNLTTSSANQLLGMTAIpCACLGIFLGGLLVKKLSlsalgAIRMAMLVNLVSTACYVSFLFLGCDTG 446
Cdd:cd06174   221 SFSTLLPLFLLDLGGLSVAVAGLLLSLFGL-AGALGSLLLGLLSDRLI-----GRKPLLLIGLLLMALGLALLLLAPSLL 294
                         410
                  ....*....|
gi 2315457141 447 PVAGVTVRYG 456
Cdd:cd06174   295 LLLLLLLLLG 304
MFS_1 pfam07690
Major Facilitator Superfamily;
47-442 3.48e-12

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 68.21  E-value: 3.48e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  47 CALMLAQGTVGAYLVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGALLSALp 126
Cdd:pfam07690   3 LAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF- 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 127 eflthqykyeageirwgaegrdvcatngsssdegpdpdlicrnrtATNMmyLLLIGAQVLLGIGATPVQPLGVSYIDDHV 206
Cdd:pfam07690  82 ---------------------------------------------ASSL--WLLLVLRVLQGLGAGALFPAALALIADWF 114
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 207 RRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYvdavfidtsnlditpdDPRWIgawwggFLLCGALLFFSSLLMFGFp 286
Cdd:pfam07690 115 PPEERGRALGLVSAGFGLGAALGPLLGGLLASLF----------------GWRAA------FLILAILSLLAAVLLLLP- 171
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 287 qslpphsepgmeseqamLPEREYERPKPSNGVlrhplepdssascfqqLRVIPKVTKHLLSNPVFTCIVLAACMeIAVVA 366
Cdd:pfam07690 172 -----------------RPPPESKRPKPAEEA----------------RLSLIVAWKALLRDPVLWLLLALLLF-GFAFF 217
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2315457141 367 GFAAFLGKYLEqQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKklslsaLGAIRMAMLVNLVSTACYVSFLFLG 442
Cdd:pfam07690 218 GLLTYLPLYQE-VLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDR------LGRRRRLLLALLLLILAALGLLLLS 286
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
42-440 1.30e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 54.12  E-value: 1.30e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141  42 FLVSECALMLAQGTVgaylVSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGAL 121
Cdd:cd17325     1 LSLALFLDMLGYGII----IPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 122 LSALpeflthqykyeageirwgaegrdvcatngsssdegpdpdlicrnrtATNmmYLLLIGAQVLLGIGATPVQPLGVSY 201
Cdd:cd17325    77 LFAF----------------------------------------------ATS--YWQLLLARFLQGLASAAVWPAAMAL 108
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 202 IDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIYvdavfidtsnlditpddprwigAWWGGFLLCGALLFFSSLL 281
Cdd:cd17325   109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADAL----------------------GYRAPFLVCAALALLALVL 166
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2315457141 282 MFGFPqslpphsepgmeseqamlpeREYERPKPSNGVlrhplepdssascfQQLRVIPKVTKHLLSNPVFTCIVLAACME 361
Cdd:cd17325   167 ALLLL--------------------PEPRPPPNKRAV--------------SAARLRSGLRLLLRDRRLLALFLAIFVLA 212
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2315457141 362 IAvVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKklslsaLGAIRMAMLVNLVSTACYVSFLF 440
Cdd:cd17325   213 FA-FGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDR------IGRKPLILIGLLLSAVALLLLPL 284
Kazal_2 pfam07648
Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. ...
474-511 1.34e-05

Kazal-type serine protease inhibitor domain; Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides.


Pssm-ID: 400135  Cd Length: 50  Bit Score: 42.87  E-value: 1.34e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 2315457141 474 NCECQTDSFTPVCGADGITYLSAC---FAGCNSTNLTG-------CAC 511
Cdd:pfam07648   3 NCQCPKTEYEPVCGSDGVTYPSPCalcAAGCKLGKEVKeekvkydGSC 50
KAZAL_FS cd00104
Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit ...
479-511 6.94e-05

Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the cognate enzyme as substrate. The reactive site peptide bond is a combining loop which has an identical conformation in all Kazal inhibitors and in all enzyme/inhibitor complexes. These Kazal domains (small hydrophobic core of alpha/beta structure with 3 to 4 disulfide bonds) often occur in tandem arrays. Similar domains are also present in follistatin (FS) and follistatin-like family members, which play an important role in tissue specific regulation. The FS domain consists of an N-terminal beta hairpin (FOLN/EGF-like domain) and a Kazal-like domain and has five disulfide bonds. Although the Kazal-like FS substructure is similar to Kazal proteinase inhibitors, no FS domain has yet been shown to be a proteinase inhibitor. Follistatin-like family members include SPARC, also known as, BM-40 or osteonectin, the Gallus gallus Flik protein, as well as, agrin which has a long array of FS domains. The kazal-type inhibitor domain has also been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The distant homolog, Ascidian trypsin inhibitor, is included in this CD.


Pssm-ID: 238052 [Multi-domain]  Cd Length: 41  Bit Score: 40.33  E-value: 6.94e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 2315457141 479 TDSFTPVCGADGITYLSACFAGC-------NSTNLTGCAC 511
Cdd:cd00104     2 PKEYDPVCGSDGKTYSNECHLGCaacrsgrSITVAHNGPC 41
KAZAL smart00280
Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and ...
471-503 2.40e-03

Kazal type serine protease inhibitors; Kazal type serine protease inhibitors and follistatin-like domains.


Pssm-ID: 197624  Cd Length: 46  Bit Score: 36.12  E-value: 2.40e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 2315457141  471 CNNNCecqTDSFTPVCGADGITYLSACF---AGCNS 503
Cdd:smart00280   2 CPEAC---PREYDPVCGSDGVTYSNECHlckAACES 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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