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Conserved domains on  [gi|29244192|ref|NP_808393|]
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volume-regulated anion channel subunit LRRC8A [Mus musculus]

Protein Classification

Pannexin_like and LRR domain-containing protein( domain architecture ID 12117038)

Pannexin_like and LRR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-340 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


:

Pssm-ID: 463622  Cd Length: 345  Bit Score: 598.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192     1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCK---WVTKDSCNDSFRGWAASSP 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLespPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192    78 EPTYPNSTVLPTPDtgPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFV 157
Cdd:pfam12534  81 APTVSSPSASMIPE--PKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192   158 SILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDK---KSSTVSEDVEATVPMLQRTKSRIEQGIVDR-SETGVLD 233
Cdd:pfam12534 159 SILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEVpSTVSVLD 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192   234 KKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFALIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHP 313
Cdd:pfam12534 239 KKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHN 318

                         330       340
                  ....*....|....*....|....*..
gi 29244192   314 LATLFKILASFYISLVIFYGLICMYTL 340
Cdd:pfam12534 319 LAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
491-772 7.74e-41

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.48  E-value: 7.74e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQ 570
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 571 KLSINNEGTKLIVLN-----SLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLK 645
Cdd:COG4886  88 GLTDLGDLTNLTELDlsgneELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLD 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 646 LWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPp 725
Cdd:COG4886 166 LSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 29244192 726 ELFQCRKLRALHLGNNVLQSLPSrVGELTNLTQIELRGNRLECLPVE 772
Cdd:COG4886 245 ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLK 290
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-340 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 598.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192     1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCK---WVTKDSCNDSFRGWAASSP 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLespPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192    78 EPTYPNSTVLPTPDtgPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFV 157
Cdd:pfam12534  81 APTVSSPSASMIPE--PKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192   158 SILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDK---KSSTVSEDVEATVPMLQRTKSRIEQGIVDR-SETGVLD 233
Cdd:pfam12534 159 SILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEVpSTVSVLD 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192   234 KKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFALIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHP 313
Cdd:pfam12534 239 KKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHN 318

                         330       340
                  ....*....|....*....|....*..
gi 29244192   314 LATLFKILASFYISLVIFYGLICMYTL 340
Cdd:pfam12534 319 LAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
491-772 7.74e-41

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.48  E-value: 7.74e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQ 570
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 571 KLSINNEGTKLIVLN-----SLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLK 645
Cdd:COG4886  88 GLTDLGDLTNLTELDlsgneELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLD 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 646 LWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPp 725
Cdd:COG4886 166 LSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 29244192 726 ELFQCRKLRALHLGNNVLQSLPSrVGELTNLTQIELRGNRLECLPVE 772
Cdd:COG4886 245 ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLK 290
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 435-768 1.46e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.60  E-value: 1.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  435 LSG-IPDTVFDLVELEVLKLeLIPDVT--IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIK-EIPL 510
Cdd:PLN00113 224 LSGeIPYEIGGLTSLNHLDL-VYNNLTgpIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPE 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  511 WIYSLKTLEELHLTGNlsaeNNRYIVIDGLRELKRLKVLRLKSNlsKLP-QVVTDVGVH----LQKLSINNEGTKLIvlN 585
Cdd:PLN00113 303 LVIQLQNLEILHLFSN----NFTGKIPVALTSLPRLQVLQLWSN--KFSgEIPKNLGKHnnltVLDLSTNNLTGEIP--E 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  586 SLKKMVNLTELELIRCDLE-RIPHSIFSLHNLQEIDLKDNNLK-------------------------TIE----EIISF 635
Cdd:PLN00113 375 GLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgelpseftklplvyfldisnnnlqgRINsrkwDMPSL 454

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  636 QHLH-----------------RLTCLKLWYNHIA-YIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDLSHNN 696
Cdd:PLN00113 455 QMLSlarnkffgglpdsfgskRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQ 534

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29244192  697 LT-FLPADIGLLQNLQNLAVTANRIEA-LPPELFQCRKLRALHLGNNVLQ-SLPSrVGELTNLTQIELRGNRLEC 768
Cdd:PLN00113 535 LSgQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNVESLVQVNISHNHLHgSLPS-TGAFLAINASAVAGNIDLC 608
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 612-764 5.37e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.82  E-value: 5.37e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 612 SLHNLQEIDLKDNNLKTIEeiiSFQHLHRLTCLKLWYNHIAYIPiQIGNLTNLERLYLNRNKIEKIpTQLFYCRKLRYLD 691
Cdd:cd21340  22 LCKNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV-EGLENLTNLEELH 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 692 LSHNNL------TFLPADI-GLLQNLQNLAVTANRIEALPPeLFQCRKLRALHLGNNVLQSLP---SRVGELTNLTQIEL 761
Cdd:cd21340  97 IENQRLppgeklTFDPRSLaALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDL 175


                ...
gi 29244192 762 RGN 764
Cdd:cd21340 176 TGN 178
LRR_8 pfam13855
Leucine rich repeat;
640-697 1.65e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.65e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192   640 RLTCLKLWYNHIAYI-PIQIGNLTNLERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNL 697
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
LRR smart00370
Leucine-rich repeats, outliers;
661-682 9.57e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 9.57e-03
                           10        20
                   ....*....|....*....|..
gi 29244192    661 LTNLERLYLNRNKIEKIPTQLF 682
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAF 22
 
Name Accession Description Interval E-value
Pannexin_like pfam12534
Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains ...
 1-340 0e+00

Pannexin-like TM region of LRRC8; Pannexin_like is a family of the four transmembrane domains of metazoan leucine-rich-repeat-containing 8 proteins. These four TMs associate into hexamers resulting in homo- or heteromeric channels that connect the cytosol to the extracellular space. The family is found in association with pfam00560.


Pssm-ID: 463622  Cd Length: 345  Bit Score: 598.06  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192     1 MIPVTELRYFADTQPAYRILKPWWDVFTDYISIVMLMIAVFGGTLQVTQDKMICLPCK---WVTKDSCNDSFRGWAASSP 77
Cdd:pfam12534   1 MFPVTELRSFNEQQPAYRILKPWWDVFMDYLSVAMLMIAVFGGTLQLTQDKVVCLPCLespPSTASLDDSYANSLSPTQS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192    78 EPTYPNSTVLPTPDtgPTGIKYDLDRHQYNYVDAVCYENRLHWFAKYFPYLVLLHTLIFLACSNFWFKFPRTSSKLEHFV 157
Cdd:pfam12534  81 APTVSSPSASMIPE--PKGRKTNLDRQQYVFINQVCYEKALHWYSKYFPYLVLIHTLIFMVSSNFWFKFPGTSSKIEHFV 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192   158 SILLKCFDSPWTTRALSETVVEESDPKPAFSKMNGSMDK---KSSTVSEDVEATVPMLQRTKSRIEQGIVDR-SETGVLD 233
Cdd:pfam12534 159 SILGKCFDSPWTTRALSETSGEDSEEKKQRLEGNTVLPKvssSSSLSSSDESAPLTRTPSVKSSPEKPVVEVpSTVSVLD 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192   234 KKEGEQAKALFEKVKKFRTHVEEGDIVYRLYMRQTIIKVIKFALIICYTVYYVHNIKFDVDCTVDIESLTGYRTYRCAHP 313
Cdd:pfam12534 239 KKEGEQAKALFEKVKKFRAHVEESDIIYKMYVAQTVLKVLKFLLILSYTSYLVSNISFTVDCKPDIEALTGYSRFYCNHN 318

                         330       340
                  ....*....|....*....|....*..
gi 29244192   314 LATLFKILASFYISLVIFYGLICMYTL 340
Cdd:pfam12534 319 LAFLFSKLLVFYISLVGVYGLLCLYTL 345
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
491-772 7.74e-41

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 155.48  E-value: 7.74e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 491 LRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQ 570
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 571 KLSINNEGTKLIVLN-----SLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLK 645
Cdd:COG4886  88 GLTDLGDLTNLTELDlsgneELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE--PLGNLTNLKSLD 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 646 LWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPp 725
Cdd:COG4886 166 LSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP- 244

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 29244192 726 ELFQCRKLRALHLGNNVLQSLPSrVGELTNLTQIELRGNRLECLPVE 772
Cdd:COG4886 245 ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLK 290
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
503-781 3.89e-40

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 153.17  E-value: 3.89e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 503 TDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLI 582
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 583 VLNSLKKMVNLTELELIRCDleriphSIFSLHNLQEIDLKDNNLKTIEEIISfqHLHRLTCLKLWYNHIAYIPIQIGNLT 662
Cdd:COG4886  88 GLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELA--NLTNLKELDLSNNQLTDLPEPLGNLT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 663 NLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNV 742
Cdd:COG4886 160 NLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQ 239

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 29244192 743 LQSLPSrVGELTNLTQIELRGNRLECLPvELGECPLLKR 781
Cdd:COG4886 240 LTDLPE-LGNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
517-799 5.66e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 143.92  E-value: 5.66e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 517 TLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMVNLTEL 596
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 597 ELIRCDLerIPHSIFSLHNLQEIDLKDNNlktieeiiSFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEK 676
Cdd:COG4886  81 LLSLLLL--GLTDLGDLTNLTELDLSGNE--------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 677 IPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGELTNL 756
Cdd:COG4886 151 LPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNL 230

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 29244192 757 TQIELRGNRLECLPvELGECPLLKRsgLVVEEDLFSTLPPEVK 799
Cdd:COG4886 231 ETLDLSNNQLTDLP-ELGNLTNLEE--LDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
503-766 8.50e-35

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 137.76  E-value: 8.50e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 503 TDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSN--LSKLPQvvtdvgvhLQKLSINNegTK 580
Cdd:COG4886  55 LLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNeeLSNLTN--------LESLDLSG--NQ 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 581 LIVL-NSLKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLKLWYNHIAYIPIQIG 659
Cdd:COG4886 125 LTDLpEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE--ELGNLTNLKELDLSNNQITDLPEPLG 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 660 NLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPaDIGLLQNLQNLAVTANRIEALPPELfQCRKLRALHLG 739
Cdd:COG4886 203 NLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLA-NLTNLKTLDLS 280

                       250       260
                ....*....|....*....|....*..
gi 29244192 740 NNVLQSLPSRVGELTNLTQIELRGNRL 766
Cdd:COG4886 281 NNQLTDLKLKELELLLGLNSLLLLLLL 307
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
435-775 7.77e-32

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 128.90  E-value: 7.77e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 435 LSGIPDTVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYS 514
Cdd:COG4886  15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 515 LKTLEELHLTGNlsaennryiviDGLRELKRLKVLRLKSN-LSKLPQVVTDVgVHLQKLSINNegTKLIVL-NSLKKMVN 592
Cdd:COG4886  95 LTNLTELDLSGN-----------EELSNLTNLESLDLSGNqLTDLPEELANL-TNLKELDLSN--NQLTDLpEPLGNLTN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 593 LTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEiiSFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRN 672
Cdd:COG4886 161 LKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE--PLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN 238

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 673 KIEKIPtQLFYCRKLRYLDLSHNNLTFLPaDIGLLQNLQNLAVTANRIEALPPELFQCRKLRALHLGNNVLQSLPSRVGE 752
Cdd:COG4886 239 QLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLIL 316

                       330       340
                ....*....|....*....|...
gi 29244192 753 LTNLTQIELRGNRLECLPVELGE 775
Cdd:COG4886 317 LLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
347-729 9.60e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 101.55  E-value: 9.60e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 347 SLKKYSFESIREESSYSDIPDVKNDFAFMLHLIDQYDPLYSKRFAVFLSEVSENKLRQLNLNNEWTLDKLRQRLTKNAQD 426
Cdd:COG4886  15 LLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGD 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 427 KLELHLFMLSGIPDtVFDLVELEVLKLELIPDVTIPPSIAQLTGLKELWLYHTAAKIEAPALAFLrENLRALHIKFTDIK 506
Cdd:COG4886  95 LTNLTELDLSGNEE-LSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNL-TNLKSLDLSNNQLT 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 507 EIPLWIYSLKTLEELHLTGNlsaennryividglrelkrlkvlrlksNLSKLPqvvtdvgvhlqklsinnegtklivlNS 586
Cdd:COG4886 173 DLPEELGNLTNLKELDLSNN---------------------------QITDLP-------------------------EP 200

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 587 LKKMVNLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIisfQHLHRLTCLKLWYNHIAYIPiQIGNLTNLER 666
Cdd:COG4886 201 LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL---GNLTNLEELDLSNNQLTDLP-PLANLTNLKT 276

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 29244192 667 LYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAVTANRIEALPPELFQ 729
Cdd:COG4886 277 LDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 435-768 1.46e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.60  E-value: 1.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  435 LSG-IPDTVFDLVELEVLKLeLIPDVT--IPPSIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIK-EIPL 510
Cdd:PLN00113 224 LSGeIPYEIGGLTSLNHLDL-VYNNLTgpIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSgEIPE 302

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  511 WIYSLKTLEELHLTGNlsaeNNRYIVIDGLRELKRLKVLRLKSNlsKLP-QVVTDVGVH----LQKLSINNEGTKLIvlN 585
Cdd:PLN00113 303 LVIQLQNLEILHLFSN----NFTGKIPVALTSLPRLQVLQLWSN--KFSgEIPKNLGKHnnltVLDLSTNNLTGEIP--E 374

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  586 SLKKMVNLTELELIRCDLE-RIPHSIFSLHNLQEIDLKDNNLK-------------------------TIE----EIISF 635
Cdd:PLN00113 375 GLCSSGNLFKLILFSNSLEgEIPKSLGACRSLRRVRLQDNSFSgelpseftklplvyfldisnnnlqgRINsrkwDMPSL 454

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  636 QHLH-----------------RLTCLKLWYNHIA-YIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDLSHNN 696
Cdd:PLN00113 455 QMLSlarnkffgglpdsfgskRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQ 534

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29244192  697 LT-FLPADIGLLQNLQNLAVTANRIEA-LPPELFQCRKLRALHLGNNVLQ-SLPSrVGELTNLTQIELRGNRLEC 768
Cdd:PLN00113 535 LSgQIPASFSEMPVLSQLDLSQNQLSGeIPKNLGNVESLVQVNISHNHLHgSLPS-TGAFLAINASAVAGNIDLC 608
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 612-764 5.37e-15

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 74.82  E-value: 5.37e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 612 SLHNLQEIDLKDNNLKTIEeiiSFQHLHRLTCLKLWYNHIAYIPiQIGNLTNLERLYLNRNKIEKIpTQLFYCRKLRYLD 691
Cdd:cd21340  22 LCKNLKVLYLYDNKITKIE---NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV-EGLENLTNLEELH 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 692 LSHNNL------TFLPADI-GLLQNLQNLAVTANRIEALPPeLFQCRKLRALHLGNNVLQSLP---SRVGELTNLTQIEL 761
Cdd:cd21340  97 IENQRLppgeklTFDPRSLaALSNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISDLEellDLLSSWPSLRELDL 175


                ...
gi 29244192 762 RGN 764
Cdd:cd21340 176 TGN 178
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 546-792 2.83e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 77.20  E-value: 2.83e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  546 LKVLRLKSNL--SKLPQvvtDVGVhLQKLSINNEGTKLIVLNSLKKMVNLTELELIRCDLER----IPHSIFSLHNLQEI 619
Cdd:PLN00113 142 LETLDLSNNMlsGEIPN---DIGS-FSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQlvgqIPRELGQMKSLKWI 217

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  620 DLKDNNL-----KTIEEIISFQHLhrltclKLWYNHIA-YIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDL 692
Cdd:PLN00113 218 YLGYNNLsgeipYEIGGLTSLNHL------DLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDL 291

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  693 SHNNLTF-LPADIGLLQNLQNLAVTANRIEA-LPPELFQCRKLRALHLGNNVLQ-SLPSRVGELTNLTQIELRGNRLEcl 769
Cdd:PLN00113 292 SDNSLSGeIPELVIQLQNLEILHLFSNNFTGkIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLT-- 369

                        250       260
                 ....*....|....*....|....
gi 29244192  770 pvelGECP-LLKRSGLVVEEDLFS 792
Cdd:PLN00113 370 ----GEIPeGLCSSGNLFKLILFS 389
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 398-766 2.15e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 74.11  E-value: 2.15e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  398 SENKLRQLNL-NNEWTLDKLRQRLTknAQDKLELHLFMLSG-IPDTVFDLVELEVLKLE---LIPDvtIPPSIAQLTGLK 472
Cdd:PLN00113 116 TSSSLRYLNLsNNNFTGSIPRGSIP--NLETLDLSNNMLSGeIPNDIGSFSSLKVLDLGgnvLVGK--IPNSLTNLTSLE 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  473 ELWLYHTAAKIEAPALAFLRENLRALHIKFTDIK-EIPLWIYSLKTLEELHLT-GNLSAEnnryiVIDGLRELKRLKVLR 550
Cdd:PLN00113 192 FLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSgEIPYEIGGLTSLNHLDLVyNNLTGP-----IPSSLGNLKNLQYLF 266

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  551 LKSNlsklpqvvtdvgvhlqKLSinnegtklivlnslkkmvnltelelircdlERIPHSIFSLHNLQEIDLKDNNLK-TI 629
Cdd:PLN00113 267 LYQN----------------KLS------------------------------GPIPPSIFSLQKLISLDLSDNSLSgEI 300

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  630 EEIISfqHLHRLTCLKLWYNHI-AYIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDLSHNNLT-FLPADIGL 706
Cdd:PLN00113 301 PELVI--QLQNLEILHLFSNNFtGKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCS 378

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29244192  707 LQNLQNLAVTANRIEA-LPPELFQCRKLRALHLGNNVLQ-SLPSRVGELTNLTQIELRGNRL 766
Cdd:PLN00113 379 SGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 627-781 2.67e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.81  E-value: 2.67e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 627 KTIEEIISFQHLHRLTCLKLWYNHIAYIPiQIGNLTNLERLYLNRNKIEKIPtQLFYCRKLRYLDLSHNNLTFLpadIGL 706
Cdd:cd21340  12 KNITKIDNLSLCKNLKVLYLYDNKITKIE-NLEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV---EGL 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 707 --LQNLQNLAVTANRieaLPPE---LFQCRKLRA-------LHLGNNVLQSLpSRVGELTNLTQIELRGNRL---ECLPV 771
Cdd:cd21340  87 enLTNLEELHIENQR---LPPGeklTFDPRSLAAlsnslrvLNISGNNIDSL-EPLAPLRNLEQLDASNNQIsdlEELLD 162

                       170
                ....*....|
gi 29244192 772 ELGECPLLKR 781
Cdd:cd21340 163 LLSSWPSLRE 172
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 605-774 1.96e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 1.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  605 RIPHSIFSLHNLQEIDLKDNNLK-TIEEIIsFQHLHRLTCLKLWYNHIAYiPIQIGNLTNLERLYLNRNKIE-KIPTQLF 682
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSgPIPDDI-FTTSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSgEIPNDIG 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  683 YCRKLRYLDLSHNNLT-FLPADIGLLQNLQNLAVTANRIEA-LPPELFQCRKLRALHLG-NNVLQSLPSRVGELTNLTQI 759
Cdd:PLN00113 162 SFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGyNNLSGEIPYEIGGLTSLNHL 241

                        170
                 ....*....|....*.
gi 29244192  760 ELRGNRLE-CLPVELG 774
Cdd:PLN00113 242 DLVYNNLTgPIPSSLG 257
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
585-795 5.54e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 5.54e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  585 NSLKKmvNLTELELIRCDLERIPHSIfsLHNLQEIDLKDNNLKTIEEiisfqHLH-RLTCLKLWYNHIAYIPIQIGNltN 663
Cdd:PRK15370 174 DCLKN--NKTELRLKILGLTTIPACI--PEQITTLILDNNELKSLPE-----NLQgNIKTLYANSNQLTSIPATLPD--T 242

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  664 LERLYLNRNKIEKIPTQL--------FYCRK-----------LRYLDLSHNNLTFLPADigLLQNLQNLAVTANRIEALP 724
Cdd:PRK15370 243 IQEMELSINRITELPERLpsalqsldLFHNKisclpenlpeeLRYLSVYDNSIRTLPAH--LPSGITHLNVQSNSLTALP 320

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 29244192  725 PELFQcrKLRALHLGNNVLQSLPSRV-GELTNLtqiELRGNRLECLPVELGecPLLKRsgLVVEEDLFSTLP 795
Cdd:PRK15370 321 ETLPP--GLKTLEAGENALTSLPASLpPELQVL---DVSKNQITVLPETLP--PTITT--LDVSRNALTNLP 383
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 664-780 7.85e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 7.85e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  664 LERLYLNRNKIE-KIPTQLFY-CRKLRYLDLSHNNLTFlPADIGLLQNLQNLAVTANRIEA-LPPELFQCRKLRALHLGN 740
Cdd:PLN00113  95 IQTINLSNNQLSgPIPDDIFTtSSSLRYLNLSNNNFTG-SIPRGSIPNLETLDLSNNMLSGeIPNDIGSFSSLKVLDLGG 173

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 29244192  741 NVLQS-LPSRVGELTNLTQIELRGNRLEC-LPVELGECPLLK 780
Cdd:PLN00113 174 NVLVGkIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLK 215
LRR_8 pfam13855
Leucine rich repeat;
640-697 1.65e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.65e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192   640 RLTCLKLWYNHIAYI-PIQIGNLTNLERLYLNRNKIEKIPTQLFYC-RKLRYLDLSHNNL 697
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 690-778 2.49e-07

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 54.44  E-value: 2.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  690 LDLSHNNLT-FLPADIGLLQNLQNLAVTANRIE-ALPPELFQCRKLRALHLGNNVLQ-SLPSRVGELTNLTQIELRGNRL 766
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502

                         90
                 ....*....|...
gi 29244192  767 EC-LPVELGECPL 778
Cdd:PLN03150 503 SGrVPAALGGRLL 515
LRR_8 pfam13855
Leucine rich repeat;
662-720 2.52e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 2.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29244192   662 TNLERLYLNRNKIEKIPTQLFY-CRKLRYLDLSHNNLTFL-PADIGLLQNLQNLAVTANRI 720
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
708-766 4.58e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 4.58e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29244192   708 QNLQNLAVTANRIEALPPELFQ-CRKLRALHLGNNVLQSLPSRVGE-LTNLTQIELRGNRL 766
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 515-695 5.17e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 51.33  E-value: 5.17e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 515 LKTLEELHLtgnlsaeNNRYIV-IDGLRELKRLKVLRLKSN-LSKLPQVVTDVG---VHLQklsiNNEGTKLIVLNSLKk 589
Cdd:cd21340   1 LKRITHLYL-------NDKNITkIDNLSLCKNLKVLYLYDNkITKIENLEFLTNlthLYLQ----NNQIEKIENLENLV- 68

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 590 mvNLTELEL----IRC--DLEriphsifSLHNLQEIDLKDNNLKTIEEII----SFQHL-HRLTCLKLWYNHIAYIpIQI 658
Cdd:cd21340  69 --NLKKLYLggnrISVveGLE-------NLTNLEELHIENQRLPPGEKLTfdprSLAALsNSLRVLNISGNNIDSL-EPL 138

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 29244192 659 GNLTNLERLYLNRNKIEKIP--TQLFY-CRKLRYLDLSHN 695
Cdd:cd21340 139 APLRNLEQLDASNNQISDLEelLDLLSsWPSLRELDLTGN 178
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 444-711 6.22e-07

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 53.34  E-value: 6.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192   444 DLVELEVL--KLELIPDvtippSIAQLTGLKELWLYHTAAKIEAPALAfLRENLRALHI-KFTDIKEIPLWIYSLKTLEE 520
Cdd:PLN03210  612 NLVKLQMQgsKLEKLWD-----GVHSLTGLRNIDLRGSKNLKEIPDLS-MATNLETLKLsDCSSLVELPSSIQYLNKLED 685

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192   521 LHLTGNLSAENnryiVIDGLrELKRLKVLRLK--SNLSKLPQVVTDVG---------------VHLQKL--------SIN 575
Cdd:PLN03210  686 LDMSRCENLEI----LPTGI-NLKSLYRLNLSgcSRLKSFPDISTNISwldldetaieefpsnLRLENLdelilcemKSE 760

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192   576 NEGTKLIVLNSLKKMVNLTELELIRCD---LERIPHSIFSLHNLQEIDLKD-NNLKTIEEIISFQHLHRLT---CLKL-W 647
Cdd:PLN03210  761 KLWERVQPLTPLMTMLSPSLTRLFLSDipsLVELPSSIQNLHKLEHLEIENcINLETLPTGINLESLESLDlsgCSRLrT 840

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 29244192   648 YNHIAyipiqignlTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSH-NNLTFLPADIGLLQNLQ 711
Cdd:PLN03210  841 FPDIS---------TNISDLNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHLE 896
LRR_8 pfam13855
Leucine rich repeat;
592-651 1.59e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.59e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29244192   592 NLTELELIRCDLERIPHSIFS-LHNLQEIDLKDNNLKTIEEiISFQHLHRLTCLKLWYNHI 651
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSP-GAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 476-667 8.08e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 47.86  E-value: 8.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 476 LYHTAAKIEA-PALAFLReNLRALHIKFTDIKEIPLwIYSLKTLEELHLtgnlsaENNRYIVIDGLRELKRLKVLRLKSN 554
Cdd:cd21340   7 LYLNDKNITKiDNLSLCK-NLKVLYLYDNKITKIEN-LEFLTNLTHLYL------QNNQIEKIENLENLVNLKKLYLGGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192 555 -------LSKLPQvvtdvgvhLQKLSINN----EGTKLIV----LNSLKKmvNLTELELIRCDLERIpHSIFSLHNLQEI 619
Cdd:cd21340  79 risvvegLENLTN--------LEELHIENqrlpPGEKLTFdprsLAALSN--SLRVLNISGNNIDSL-EPLAPLRNLEQL 147

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 29244192 620 DLKDNNLKTIEEII-SFQHLHRLTCLKLWYNHIAYIPI----QIGNLTNLERL 667
Cdd:cd21340 148 DASNNQISDLEELLdLLSSWPSLRELDLTGNPVCKKPKyrdkIILASKSLEVL 200
PLN03150 PLN03150
hypothetical protein; Provisional
 606-681 2.58e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.89  E-value: 2.58e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 29244192  606 IPHSIFSLHNLQEIDLKDNNLKTieEI-ISFQHLHRLTCLKLWYNHI-AYIPIQIGNLTNLERLYLNRNKIE-KIPTQL 681
Cdd:PLN03150 434 IPNDISKLRHLQSINLSGNSIRG--NIpPSLGSITSLEVLDLSYNSFnGSIPESLGQLTSLRILNLNGNSLSgRVPAAL 510
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
645-783 1.81e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.15  E-value: 1.81e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  645 KLWY--NHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLfyCRKLRYldlsHNNLTFLPAdigLLQNLQNLAVTANRIEA 722
Cdd:PRK15387 286 KLWIfgNQLTSLPVLPPGLQELSVSDNQLASLPALPSEL--CKLWAY----NNQLTSLPT---LPSGLQELSVSDNQLAS 356

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 29244192  723 LPPELFQCRKLRALhlgNNVLQSLPSRVgelTNLTQIELRGNRLECLPVELGECPLLKRSG 783
Cdd:PRK15387 357 LPTLPSELYKLWAY---NNRLTSLPALP---SGLKELIVSGNRLTSLPVLPSELKELMVSG 411
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 662-697 2.33e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 39.15  E-value: 2.33e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 29244192   662 TNLERLYLNRNKIEKIPtQLFYCRKLRYLDLSHNNL 697
Cdd:pfam12799   1 PNLEVLDLSNNQITDIP-PLAKLPNLETLDLSGNNK 35
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
616-766 4.60e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 44.00  E-value: 4.60e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  616 LQEIDLKDNNLKTIEEIISfqhlhrlTCLKLWY--NHIAYIPI-------------QIGNL----TNLERLYLNRNKIEK 676
Cdd:PRK15387 304 LQELSVSDNQLASLPALPS-------ELCKLWAynNQLTSLPTlpsglqelsvsdnQLASLptlpSELYKLWAYNNRLTS 376

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  677 IPTqlfYCRKLRYLDLSHNNLTFLPAdigLLQNLQNLAVTANRIEALPpelFQCRKLRALHLGNNVLQSLPSRVGELTNL 756
Cdd:PRK15387 377 LPA---LPSGLKELIVSGNRLTSLPV---LPSELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPESLIHLSSE 447

                        170
                 ....*....|
gi 29244192  757 TQIELRGNRL 766
Cdd:PRK15387 448 TTVNLEGNPL 457
PLN03150 PLN03150
hypothetical protein; Provisional
 653-734 3.93e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 3.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 29244192  653 YIPIQIGNLTNLERLYLNRNKIE-KIPTQLFYCRKLRYLDLSHNNLT-FLPADIGLLQNLQNLAVTANRIEALPPELFQC 730
Cdd:PLN03150 433 FIPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSLSGRVPAALGG 512


                 ....
gi 29244192  731 RKLR 734
Cdd:PLN03150 513 RLLH 516
LRR smart00370
Leucine-rich repeats, outliers;
661-682 9.57e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 9.57e-03
                           10        20
                   ....*....|....*....|..
gi 29244192    661 LTNLERLYLNRNKIEKIPTQLF 682
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAF 22
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
661-682 9.57e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 9.57e-03
                           10        20
                   ....*....|....*....|..
gi 29244192    661 LTNLERLYLNRNKIEKIPTQLF 682
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAF 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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