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Conserved domains on  [gi|282847430|ref|NP_808455|]
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solute carrier family 15 member 5 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
33-518 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17349:

Pssm-ID: 452895  Cd Length: 437  Bit Score: 686.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  33 FRVGICLLLVELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHF 112
Cdd:cd17349    1 LQVVICLLLVELCERFTFFGIVCNMILFCTIKLGYRNHQAAIVNLCFVGTSTLTPVFVGWLAEECMGRNKLVYICLFLHF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 113 LGTALLSMLAFPAENFYRGAYPVFNNTSVEEQAGLFHVALLTLCLGTGGIRAVVCPPDMCGSQERESKKPMPFCNWASWS 192
Cdd:cd17349   81 LGTALLPVVAFPFEDFYIDTHHIIHTLAKREQTLLFYVALLTASLGTGGIRAIVCPLSAYGLQDYGSRKLMSFFNWFYWL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 193 ANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVTLYLKHCDLIyrpenrcslltiarafvralktrclpychfgrd 272
Cdd:cd17349  161 VNLNSAVVFVGISYIQQSVAKNLGFLIPFMSVLMALITLHMVRNDLI--------------------------------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 273 gsswldhamekqgghhselqeeDTRNISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGGFSLPIALMNAISLLPL 352
Cdd:cd17349  208 ----------------------NTKNLVRLFPLFAFQILYRTCIMQIPSGYYLQTMNSNLNLGGFLLPIAAMNVISIIPL 265
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 353 LILPPFMDYFSNCLLPSKRDGPFLSACMIAGNICAASSVAMAGFLEIYRKLAR--EQSPSGKLFSVSSMACVCLVPQYVL 430
Cdd:cd17349  266 LILAPFLEYFSSCLFSSKRYGPFLSACIIAGHLCAALSVMVAGFSEIHRKRFPlvEQTLSGKVLLVSSMPCFQLAPQYVL 345
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 431 LGVSEVLVNPAVSMVTHRVIP----GASMAFLTLSHGSACFAGAMLIKLLYLISEGNWFPNTLDKGNLENFFFVLASLML 506
Cdd:cd17349  346 LGVAEALVTPACSLITFRLVPssirGISMHFLTLFNGAGCFMGALLIQLVYLISEGNWFPNTLNKGNLERFFFFLASLML 425
                        490
                 ....*....|..
gi 282847430 507 LNILGLWRASWR 518
Cdd:cd17349  426 LNALGFWRISHR 437
 
Name Accession Description Interval E-value
MFS_SLC15A5 cd17349
Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute ...
33-518 0e+00

Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 5 (SLC15A5) is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. The specific function of SLC15A5 is unknown. SLC15A5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340907  Cd Length: 437  Bit Score: 686.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  33 FRVGICLLLVELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHF 112
Cdd:cd17349    1 LQVVICLLLVELCERFTFFGIVCNMILFCTIKLGYRNHQAAIVNLCFVGTSTLTPVFVGWLAEECMGRNKLVYICLFLHF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 113 LGTALLSMLAFPAENFYRGAYPVFNNTSVEEQAGLFHVALLTLCLGTGGIRAVVCPPDMCGSQERESKKPMPFCNWASWS 192
Cdd:cd17349   81 LGTALLPVVAFPFEDFYIDTHHIIHTLAKREQTLLFYVALLTASLGTGGIRAIVCPLSAYGLQDYGSRKLMSFFNWFYWL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 193 ANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVTLYLKHCDLIyrpenrcslltiarafvralktrclpychfgrd 272
Cdd:cd17349  161 VNLNSAVVFVGISYIQQSVAKNLGFLIPFMSVLMALITLHMVRNDLI--------------------------------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 273 gsswldhamekqgghhselqeeDTRNISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGGFSLPIALMNAISLLPL 352
Cdd:cd17349  208 ----------------------NTKNLVRLFPLFAFQILYRTCIMQIPSGYYLQTMNSNLNLGGFLLPIAAMNVISIIPL 265
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 353 LILPPFMDYFSNCLLPSKRDGPFLSACMIAGNICAASSVAMAGFLEIYRKLAR--EQSPSGKLFSVSSMACVCLVPQYVL 430
Cdd:cd17349  266 LILAPFLEYFSSCLFSSKRYGPFLSACIIAGHLCAALSVMVAGFSEIHRKRFPlvEQTLSGKVLLVSSMPCFQLAPQYVL 345
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 431 LGVSEVLVNPAVSMVTHRVIP----GASMAFLTLSHGSACFAGAMLIKLLYLISEGNWFPNTLDKGNLENFFFVLASLML 506
Cdd:cd17349  346 LGVAEALVTPACSLITFRLVPssirGISMHFLTLFNGAGCFMGALLIQLVYLISEGNWFPNTLNKGNLERFFFFLASLML 425
                        490
                 ....*....|..
gi 282847430 507 LNILGLWRASWR 518
Cdd:cd17349  426 LNALGFWRISHR 437
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
100-481 2.69e-13

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 71.58  E-value: 2.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  100 RNKLMYIALsLHFLGTALLSMLAFPAenfyrGAYPVfnntsveeQAGLFHVALLTLCLGTGGIRAvvCPPDMCGSQ--ER 177
Cdd:pfam00854   1 FRTIFLGSI-IYAIGHILLALSAIPS-----LRPPV--------HVALFFIGLALIALGTGGIKP--NVSSFGGDQfeET 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  178 ESKKPMPFCNWASWSANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVTLYL-----KHcdliYRPE-------NR 245
Cdd:pfam00854  65 DPRRRSRFFSIFYFSINAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLgsrmyKK----KPPKgnvltkvFK 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  246 CSLLTIARAFVRALKTRCLPYCHfgrdgssWLDHAMEKQG--------------GHHSELQEEDTRNISALLPLFSFQIL 311
Cdd:pfam00854 141 VLPVAAWNKVKLNGSSAGIKKLH-------WLDWARELDAliilgivvpgiffnIWCTKTKVEEVKRLLRVLPLFLPLIM 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  312 YRTCLLQIPSGYYLQTMNSNRNWGGFSLPIALMNAISLLPLLILPPFMDYFSNCLLPSKRDGPFLSACMIAGNICAASSV 391
Cdd:pfam00854 214 FWALYDQMGTSWVLQARTMNRKIGSFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKCTGGLTPLQKMAVGLFLASLAF 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  392 AMAGFLEIYRKLAREQSPSGKLFSVSsmacVC-LVPQYVLLGVSEVLVNP-AVSMVTHRVIP---GASMAFLTLSHGSAC 466
Cdd:pfam00854 294 AIAAIVQLKRNDTGPEFPIAQEVPIS----VLwLIPQYLLIGFGELFISIgGLEFFYKLAPKsmtSLITGLFLLTNALGN 369
                         410
                  ....*....|....*
gi 282847430  467 FAGAMLIKLLYLISE 481
Cdd:pfam00854 370 FLSGVIATLTAKPTN 384
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
39-485 8.70e-09

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 225646 [Multi-domain]  Cd Length: 498  Bit Score: 58.06  E-value: 8.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  39 LLLVELCERFTFFEVVCNMIPFCTGRLG---SYNHQAAMLNLGFIGTSV-LTPVFMGWLADEYFGRNKLMYIALSLHFLG 114
Cdd:COG3104   26 IFFVELWERFSYYGMRAILILYLYYQLGdglGFDETHATGLFSAYGSLVyLTPIIGGWLADRVLGTRRTIVLGAILMAIG 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 115 TALLSMLAFPAenfyrgaypvfnntsveeqAGLFHVALLTLCLGTGGIRAvvCPPDMCGSQ--ERESKKPMPFcnwasws 192
Cdd:COG3104  106 HLVLAISSVSG-------------------PGGLYIGLALIIVGTGLFKP--NISSLLGELypKDDPRRDGGF------- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 193 aNLNAAVVFLGiSSIQPLGSGALGILLPSLSVFTA---------LVTLYLKHCDLIYRPENRCSLLT--IARAFVRALKT 261
Cdd:COG3104  158 -TLFYMGINIG-SLIAPIITGLLAINYGWHVGFGLaavgmiiglVIFLLGRRHVKGIGGVPDPNPLSfnFLLPVLGGLVV 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 262 RCLPYCHFGRDGSSWLDHAMEKQGGHH----------SELQEEDTRNISALLPLFSFQILYRTCLLQIPSGYYLQ-TMNS 330
Cdd:COG3104  236 MILAALLTLLLNQNTFSGVLLVISILIaiiyfaeafrSPKVFDERRRLLAAIPLFLFAVIFWALYEQMGSSLNLYaDRNV 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 331 NRNWGGFSLPIALMNAISLLPLLILPPFMDYFSNCLLPSKRDgPFLSACMIAGNICAASSVAMAGFLEIYRKLareqsPS 410
Cdd:COG3104  316 NRQIFGFEVPPAWFQSLNPFFIILFSPILAALWTKLGRGNKQ-PSTPIKFALGLILAGLGFLILLLAGIWFGG-----PS 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 411 GKLfSVSSMacvclVPQYVLLGVSEVLVNP-AVSMVTHRVIPG-----ASMAFLTLSHG---SACFAG--AMLIKLLYLI 479
Cdd:COG3104  390 GLV-SVWWL-----VLSYVLQSFGELFISPvGLSMVTKLAPPAlksfiMAMWFLTVAAGqtlGGQVAGltAVTDPAYTAF 463

                 ....*.
gi 282847430 480 SEGNWF 485
Cdd:COG3104  464 IEGRVF 469
 
Name Accession Description Interval E-value
MFS_SLC15A5 cd17349
Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute ...
33-518 0e+00

Solute Carrier family 15 member 5 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 member 5 (SLC15A5) is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. The specific function of SLC15A5 is unknown. SLC15A5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340907  Cd Length: 437  Bit Score: 686.87  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  33 FRVGICLLLVELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHF 112
Cdd:cd17349    1 LQVVICLLLVELCERFTFFGIVCNMILFCTIKLGYRNHQAAIVNLCFVGTSTLTPVFVGWLAEECMGRNKLVYICLFLHF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 113 LGTALLSMLAFPAENFYRGAYPVFNNTSVEEQAGLFHVALLTLCLGTGGIRAVVCPPDMCGSQERESKKPMPFCNWASWS 192
Cdd:cd17349   81 LGTALLPVVAFPFEDFYIDTHHIIHTLAKREQTLLFYVALLTASLGTGGIRAIVCPLSAYGLQDYGSRKLMSFFNWFYWL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 193 ANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVTLYLKHCDLIyrpenrcslltiarafvralktrclpychfgrd 272
Cdd:cd17349  161 VNLNSAVVFVGISYIQQSVAKNLGFLIPFMSVLMALITLHMVRNDLI--------------------------------- 207
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 273 gsswldhamekqgghhselqeeDTRNISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGGFSLPIALMNAISLLPL 352
Cdd:cd17349  208 ----------------------NTKNLVRLFPLFAFQILYRTCIMQIPSGYYLQTMNSNLNLGGFLLPIAAMNVISIIPL 265
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 353 LILPPFMDYFSNCLLPSKRDGPFLSACMIAGNICAASSVAMAGFLEIYRKLAR--EQSPSGKLFSVSSMACVCLVPQYVL 430
Cdd:cd17349  266 LILAPFLEYFSSCLFSSKRYGPFLSACIIAGHLCAALSVMVAGFSEIHRKRFPlvEQTLSGKVLLVSSMPCFQLAPQYVL 345
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 431 LGVSEVLVNPAVSMVTHRVIP----GASMAFLTLSHGSACFAGAMLIKLLYLISEGNWFPNTLDKGNLENFFFVLASLML 506
Cdd:cd17349  346 LGVAEALVTPACSLITFRLVPssirGISMHFLTLFNGAGCFMGALLIQLVYLISEGNWFPNTLNKGNLERFFFFLASLML 425
                        490
                 ....*....|..
gi 282847430 507 LNILGLWRASWR 518
Cdd:cd17349  426 LNALGFWRISHR 437
MFS_POT cd06175
Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of ...
36-513 1.46e-102

Proton-coupled oligopeptide transporter (POT) family of the Major Facilitator Superfamily of transporters; The Proton-coupled oligopeptide transporter (POT) family is present across all major kingdoms of life and is known by a variety of names. It is referred to as the Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) in plants, and in addition to POT, it is also known as the Peptide transporter (PepT/PTR) or Solute Carrier 15 (SLC15) family in animals. Members of this family are proton-driven symporters involved in nitrogen acquisition in the form of di- and tripeptides. Plant members transport other nitrogenous ligands including nitrate, the plant hormone auxin, and glucosinolate compounds that are important for seed defense. POT proteins exhibit substrate multispecificity, with one transporter able to recognize as many as 8,400 types of di/tripeptides and certain peptide-like drugs. The POT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340865 [Multi-domain]  Cd Length: 422  Bit Score: 315.91  E-value: 1.46e-102
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  36 GICLLLVELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLGT 115
Cdd:cd06175    1 CAMILLIELCERFTFYGIGANLVPFLTGALGLGNAQAANVVLNFLGTSYVTPLFGGWIADTFLGRYRTILIGAAIYAVGV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 116 ALLSMLAFPAENFYRGAYPVFNNTSVEEQAGLFHVALLTLCLGTGGIRAVVCPPDMCGSQERESKKPMPFCNWASWSANL 195
Cdd:cd06175   81 AILTVSTIPPGLRPLRCNPSHCEQASGIQLTGFYAALYLIALGTGGVKANVSPLGADQFDERGPSKTQSFFNWFYFCINV 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 196 NAAVVFLGISSIQPLGSGALGILLPSLSVFTALVTLylkhcdliyrpenrcslltiarafvralktrclpychfgrdgss 275
Cdd:cd06175  161 GSLLAMLGTPYIQDNVGWAAAYGIPFVAILLALVVF-------------------------------------------- 196
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 276 wldhamekqgghhselqeeDTRNISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGGFSLPIALMNAISLLPLLIL 355
Cdd:cd06175  197 -------------------EVKQLLRALPLFAFCILFWTVYAQMTTSYVLQALTLVRSTGLFTIPPASMQAFNPILLLLL 257
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 356 PPFMDYFSNCLLPSKRDGPFLSACMIAGNICAASSVAMAGFLEIYRKlaREQSPSGKLFSVSSMACVCLVPQYVLLGVSE 435
Cdd:cd06175  258 IPVLDKVVYPLIRRYGVGLSPLTKIGLGFFFGSLSMFVAGFLELKRL--NTAHAHGPVVTTSPLSFWWQIPQYLLLGIGE 335
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 436 VLVNPAVSMVTHRVIP----GASMAFLTLSHGSACFAGAMLIKLLYLISEGNWFPNTLDKGNLENFFFVLASLMLLNILG 511
Cdd:cd06175  336 ILVSITGLEFAYREAPksmkGFIMGLLLLTSGFGSFFGSVLVTLVSKPTDGAHIADDLNKGVLTNFFFLLAVLAALNFLI 415

                 ..
gi 282847430 512 LW 513
Cdd:cd06175  416 FL 417
MFS_NPF cd17351
Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant ...
39-517 2.12e-27

Plant NRT1/PTR family (NPF) of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340909 [Multi-domain]  Cd Length: 445  Bit Score: 115.03  E-value: 2.12e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  39 LLLVELCERFTFFEVVCNMIPFCTGRL-GSYNHQAAMLNLgFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLGTAL 117
Cdd:cd17351    4 ILGNEFAERLAFYGIAVNLVTYLTKVMhLSNAKAANTVTN-FSGTSYLTPLLGAFLADAYLGRYWTIAIFSVIYLVGLIL 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 118 LSMLAfpaenfyrgAYPVF-----NNTSVEEQAGL-----FHVALLTLCLGTGGIRAVVCP--PDMCGSQERESKKPMP- 184
Cdd:cd17351   83 LTLSA---------SVPSLrpppcNPDSPCEPASStqltvLYVGLYLIALGTGGIKPCVSAfgADQFDETDPKEKKQKPs 153
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 185 FCNWASWSANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVTLYLkhcdliyrpenrcslltiARAFVRALKTrcl 264
Cdd:cd17351  154 FFNWFYFSINLGSLLAVTLVVYIQDNVSWGWGFGIPAAAMALAVIVFVA------------------GTPFYREVKC--- 212
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 265 pychfgrdgsswldhamekqgghhselqeedtrnISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGG-FSLPIAL 343
Cdd:cd17351  213 ----------------------------------LLRLLPIWATTILLSTVYAQMQTFFVQQGLTMDRRLGGsFEIPAAS 258
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 344 MNAISLLPLLILPPFMDYFsncLLPSKRD------GPFLSACMIAGNICAASSVAMAGFLEIYR-KLAREQSPSGKLFSV 416
Cdd:cd17351  259 LSVFSTLFVLLFIPLYDRV---FVPFARRytgnprGITPLQRIGIGLVLSILAMAVAALVEVKRlRVARAHGLLDSPTGV 335
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 417 SSMACVCLVPQYVLLGVSEVLVNPA----------VSMVthrvipGASMAFLTLSHGSACFAGAMLIKLLYLISEGN--- 483
Cdd:cd17351  336 VPMSVFWLLPQYFLLGLAEVFTYIGqleffydeapDGMR------SLGTALFLLTIALGNFLSSALVTIVNKITGKGggp 409
                        490       500       510
                 ....*....|....*....|....*....|....*.
gi 282847430 484 -WFPNTLDKGNLENFFFVLASLMLLNILG-LWRASW 517
Cdd:cd17351  410 gWLPNNLNKGRLDYFYWLLAVLSAVNFLVfLVCAKW 445
MFS_NPF5 cd17417
NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The ...
37-517 1.09e-19

NRT1/PTR family (NPF), subfamily 5 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF5 includes Arabidopsis thaliana PTR3 (AtPTR3, now named AtNPF5.2), which is a wound-induced peptide transporter that is necessary for defense against virulent bacterial pathogens. NPF5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340975 [Multi-domain]  Cd Length: 452  Bit Score: 91.95  E-value: 1.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  37 ICLLLVELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLGTA 116
Cdd:cd17417    5 SFIIGIEVAERFAYYGIASNLVTYLTTPLHQSTARAAKNVNNWSGTATLLPLLGAFVADAYLGRYRTILISSLIYLLGLV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 117 LLSMLAF-----PAENFYRGAYPVFnntsveEQAGLFHVALLTLCLGTGGIRAvvCPPDMCGSQ-----ERESKKPMPFC 186
Cdd:cd17417   85 LLTLSASlpslkPPECNGTCSKAST------LQVAFFFFSLYLVAIGQGGHKP--CVQAFGADQfdeddPKEKKQKSSFF 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 187 NWasWSANLNAAVVF--LGISSIQPLGSGALGILLPSLSVFTALVTLYLKHCdlIYRpenrcslltiarafvralktrcl 264
Cdd:cd17417  157 NW--WYFSICAGSLTavTVLVYIQDNVGWALGFGIPTIVMALALFVFLLGTP--LYR----------------------- 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 265 pychfgrdgsswldhamekqgghhseLQEEDTRNISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWG-GFSLPIAL 343
Cdd:cd17417  210 --------------------------YKVEEVKLVLRLIPIWFTTLVFTVVFAQSPTFFTKQGVTMDRTIGpNFKIPPAS 263
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 344 MNAISllpLLILPPFMDYFSNCLLPSKRDgpflsacmIAGNIC------------AASSVAM--AGFLEIYRKLAREQSP 409
Cdd:cd17417  264 LQSFI---TLSILISIPIYDRVFVPIARK--------ITGNPRgitllqrigigmFLSILAMviAALVEMKRLKVAKEHG 332
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 410 SGKLFSVSSMACVCLVPQYVLLGVSEVLVnpAVSM---------VTHRVIpgaSMAFLTLSHGSACFAGAMLIKLLYLIS 480
Cdd:cd17417  333 LISPKATVPMSIFWLLPQYILLGIADVFT--MVGMqeffydqvpDEMRSL---GTALYLSVFGVGSFLSSFLISIVDKIT 407
                        490       500       510       520
                 ....*....|....*....|....*....|....*....|..
gi 282847430 481 EG----NWFPNTLDKGNLENFFFVLASLMLLNI-LGLWRASW 517
Cdd:cd17417  408 SSsggqSWFNNNLNRAHLDYFYWLLAVLSAVNFvLFLFVAKS 449
MFS_NPF7 cd17419
NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The ...
36-508 1.72e-19

NRT1/PTR family (NPF), subfamily 7 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF7 includes the nitrate transporters AtNPF7.2 and AtNPF7.3, as well as the dipeptide transporter OsNPF7.3. AtNPF7.3 is a bidirectional transporter involved in nitrate influx and efflux. NPF7 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340977 [Multi-domain]  Cd Length: 447  Bit Score: 91.28  E-value: 1.72e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  36 GICLLLVELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLGT 115
Cdd:cd17419    4 AIFILVNQGLATLAYFGVGVNLVLYLTRVMHQSNASAANNVSNWTGTVYITPLIGAFLSDSYWGRYWTSTLFQAIFVIGL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 116 ALLS----MLAFPAENFYRGAYPVFNNTSVeeQAGLFHVALLTLCLGTGGIRAVVCPpdmCGSQE------RESKKPMPF 185
Cdd:cd17419   84 LLLTlssaLPSLRPPQCGDGDLKCPPASAA--QTTFLYFSLYLIALGYGGYQPCIAT---LGADQfddedpIEKASKSAF 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 186 CNWASWSANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVtlylkhcdliyrpenrcsLLTIARAFVRALKTrclp 265
Cdd:cd17419  159 FSYFYQALNLGSLFSNTILVYFEDNGSWGLGFGISAGAAFIGLV------------------LFLAGTPFYREVKC---- 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 266 ychfgrdgsswldhamekqgghhselqeedtrnISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGGFSLPIALMN 345
Cdd:cd17419  217 ---------------------------------ILRLLPIWLSTIIYSVVYTQMATLFVEQGAAMDTSFGNFKIPPASMS 263
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 346 AISLLPLLILPPFMDYFsncLLPSKR------DGPFLSACMIAGNICAASSVAMAGFLEIYRKLAREQSPSGKLFSVSSM 419
Cdd:cd17419  264 VFEILSVAVGTVLYRKF---LVPLLRkvtghpKGITELQRMGIGLVIGILAMVVAALVEIQRLKVARPSNLDDPTSPSPL 340
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 420 ACVCLVPQYVLLGVSEVLVNPAVSMVTHRVIP------GASMAFLTLSHGSacFAGAMLIKLLYLIS----EGNWFPNTL 489
Cdd:cd17419  341 SIFWQIPQYVLVGASEVFTYVGQLEFFYDQAPdglrslGSALCMASVALGN--YLSSLLVTIVNKVTtkdgSPGWIPDNL 418
                        490
                 ....*....|....*....
gi 282847430 490 DKGNLENFFFVLASLMLLN 508
Cdd:cd17419  419 NKGHLDRFYWLLAALSGID 437
MFS_SLC15A3_4 cd17348
Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; ...
39-504 3.45e-19

Solute Carrier family 15 members 3 and 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 15 members 3 (SLC15A3) and 4 (SLC15A4) are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They are peptide/histidine transporters (PHTs) that transport free histidine in addition to di/tripeptides. SLC15A4, also called peptide transporter 4 or peptide/histidine transporter 1 (PHT1), is expressed in the human brain, retina, placenta, and immune cells. It is required for Toll-like receptor 7 (TLR7)- and TLR9-mediated type I interferon production in plasmacytoid dendritic cells (pDCs) and is involved in the pathogenesis of lupus-like autoimmunity. SLC15A3, also called osteoclast transporter, peptide transporter 3, or peptide/histidine transporter 2 (PHT2), is expressed in immune tissues including the spleen and thymus. The SLC15A3/SLC15A4 group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340906 [Multi-domain]  Cd Length: 435  Bit Score: 90.23  E-value: 3.45e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  39 LLLVELCERFTFFEVVCNMIPFCTGR-LGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLGTAL 117
Cdd:cd17348    7 VLLVELLERAAFYGITSNLVLFLNGSpFNWEGTQASQALLLFMGATYLLSPFGGWLADAYLGRFWTILLSLLLYLLGMLL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 118 LSMLAFPAenfyrgaypvfnntsveeqaglFHVALLTLCLGTGGIRAVVCPPDMCGSQERESKKPMPFCNWASWSANLNA 197
Cdd:cd17348   87 FPATAAPA----------------------LYAGLLLVGLGVGSVKANITPFGADQVKDRGPEATRRFFNWFYWSINLGA 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 198 AVVFLGISSIQPLGSGALGILLPSLSVFTALVTLYLKHCDLIyrpenrcslltiarafvralktrclpychfgrdgsswl 277
Cdd:cd17348  145 ILSLGGVAYIQQNVSFLIGYSIPAVCVGLAFLVFLCGQPVFI-------------------------------------- 186
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 278 dhamekqgghhselqeeDTRNISALLPLFSFQILYRTCLLQIPSGYYLQTMN-----------SNRNWGGFSLPIALMNA 346
Cdd:cd17348  187 -----------------DVKALVKILPVFLALIPYWTVYFQMQTTYVLQSLHlkipnifisniAGITNSSHTFPAAWLTM 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 347 ISLLPLLILPPFMDYFSNCLLpsKRDGPFLSAC--MIAGNICAASSVAMAGFLE------IYRKLAREQSPSGKLFSVSS 418
Cdd:cd17348  250 FDAVLILILIPLKDKLVDPFL--KRRGLLPSSLkrIAVGMFFVMCSAIAAGILEskrleiVKHNTTIQQQIGNVTYYAAD 327
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 419 MACVCLVPQYVLLGVSEVLVNPAVSMVTHRVIP----GASMAFLTLSHGSACFAGAMLIKLLYlISEGNWFPNTLDKGNL 494
Cdd:cd17348  328 LPIWWQIPQYLLIGISEIFASIAGLEFAYSAAPksmqSAIMGLFFFFSGVGSFVGSGLLALVS-IKEIGWMSSHKDFGNI 406
                        490
                 ....*....|....*
gi 282847430 495 EN-----FFFVLASL 504
Cdd:cd17348  407 NGcrlnyYFFLLAGI 421
MFS_NPF8 cd17418
NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The ...
43-517 9.57e-18

NRT1/PTR family (NPF), subfamily 8 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF8 contains the Arabidopsis dipeptide transporters AtNPF8.1 (PTR1), AtNPF8.2 (PTR5), and AtNPF8.3 (PTR2), as well as tonoplast-localized transporters AtNPF8.4 (PTR4) and AtNPF8.5 (PTR6). Oryza sativa NRT1 (now called OsNPF8.9) is a low-affinity nitrate transporter. NPF8 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340976 [Multi-domain]  Cd Length: 447  Bit Score: 85.99  E-value: 9.57e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  43 ELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLGTALLSMLA 122
Cdd:cd17418   11 ECCERLAYYGIATNLITYLTKELHQGNVSAANNVTNWSGTCYITPLIGAFIADAYWGRYWTIASFSAIYFIGMVLLTLSA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 123 F-----PAENFyrGAYPVFNNTSveeQAGLFHVALLTLCLGTGGIRAvvCPPDMCGSQ-----ERESKKPMPFCNWASWS 192
Cdd:cd17418   91 SvpglkPASCI--GSLCPPATSV---QYAVFFLGLYLIALGTGGIKP--CVSSFGADQfddtdPKEKVRKSSFFNWFYFS 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 193 ANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVTLYlkhcdliyrpenrcslltIARAFVRALKTrclpychfgrd 272
Cdd:cd17418  164 INIGALISSSVLVWIQENVGWGWGFGIPTVFMGIAIVSFF------------------FGTPLYREVKI----------- 214
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 273 gsswldhamekqgghhselqeedtrnISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGGFSLPIALMNAISLLPL 352
Cdd:cd17418  215 --------------------------LIRLLPIWASGIVFATVYSQMSTMFVQQGRTMDRMGGNFEIPPASLSLFDTLSV 268
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 353 LILPPFMDYFsncLLP-----SKRDGPFLS-ACMIAGNICAASSVAMAGFLEIYR-KLAREQSPSGKLFSVsSMACVCLV 425
Cdd:cd17418  269 LIWVPIYDRF---IVPlvrkfTGHERGFTQlQRMGIGLFISVLSMVAAAIVEIVRlQLARTHNLVESGPPV-PMSIFWQI 344
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 426 PQYVLLGVSEVLVNPAVSMVTHRVIPGA------SMAFLTLSHGSacFAGAMLIKLLYLISEGN----WFPNTLDKGNLE 495
Cdd:cd17418  345 PQYFLIGAAEVFTFIGQLEFFYDQSPDAmrslcsALSLLTTALGN--YLSSLIVTLVTYVTTKGgkpgWIPDNLNNGHLD 422
                        490       500
                 ....*....|....*....|...
gi 282847430 496 NFFFVLASLMLLNIL-GLWRASW 517
Cdd:cd17418  423 YFFWLLASLSFLNILvYLWIAKR 445
MFS_NPF6 cd17413
NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The ...
39-511 4.26e-17

NRT1/PTR family (NPF), subfamily 6 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter 1/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF6 includes the first identified member of the NRT1/PTR family: Arabidopsis thaliana NRT1.1, now called AtNPF6.3. It is a dual affinity nitrate influx transporter and a nitrate sensor. It also transports auxin and has nitrate efflux activity. NPF6 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340971 [Multi-domain]  Cd Length: 457  Bit Score: 84.04  E-value: 4.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  39 LLLVELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLGTALL 118
Cdd:cd17413    7 ILGIEMCERLTTLGIGVNLVTYLTGTMHLPSATSANIVTNFLGTSFLLCLLGGFIADTFLGRYLTIAIFASIQALGVLVL 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 119 SMLA-FPAenfYRGAYPVFNNTSVEEQAG-----LFHVALLTLCLGTGGIRAVVCPpdmCGSQE------RESKKPMPFC 186
Cdd:cd17413   87 TLSTtLPS---LRPPPCNHTTSHHCEPASgiqltVLYLALYLIALGTGGIKSSVSG---FGSDQfdendpKERKLMSYFF 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 187 NWASWSANLNA-----AVVFLGISSIQPLGSG-ALGILLPSLSVFTALVTLYlkhcdliyrpenrcslltiarafvRALK 260
Cdd:cd17413  161 NRFFFCISVGSllavtVLVYIQDNVGRGWGYGiCAAAMVLAIVVFLAGTKRY------------------------RFKK 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 261 TRclpychfgrdGSSwldhamekqgghhselQEEDTRNISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGGFSLP 340
Cdd:cd17413  217 SI----------GST----------------QVEEVKMVVRMLPIWATTILFWTVYAQMTTFSVEQAETMDRNIGSFEIP 270
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 341 IALMNAISLLPLLILPPFMDYFSNCLLPSKRDGPF-LSACMIAGNICAASSVAMAGFLEIYRKLAREQSPSGKLFSVSSM 419
Cdd:cd17413  271 PASMAVFLVATILLTTAVYDRVIVPLCRKLTGHPQgLTTLQRIGVGLVFSCLAMAVAALVELKRLRIAHAHGKPVKTVPM 350
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 420 ACVCLVPQYVLLGVSEVLVNPAVSMVTHRVIPGA--SMA---FL-TLSHGsaCFAGAMLIKLLYLI----SEGNWFPNTL 489
Cdd:cd17413  351 SVFWLVPQYFLVGAGEAFIYTGQLDFFIRESPKGmkSMStglFLsTLSLG--FFVSSFLVSIVNRVtgksHPHGWLADNL 428
                        490       500
                 ....*....|....*....|..
gi 282847430 490 DKGNLENFFFVLASLMLLNILG 511
Cdd:cd17413  429 NKGRLDYFYWLLAVLSALNFVI 450
MFS_NPF1_2 cd17416
NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; ...
43-519 6.53e-17

NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF1 includes Medicago truncatula LATD/NIP, now named MtNPF1.7, which is a high-affinity nitrate transporter and is involved in nodulation and root architecture. NPF2 members are well-established nitrate and glucosinolate transporters, including Arabidopsis nitrate influx and efflux transporters with varied tissue and developmental specificity. Examples are AtNPF2.7, which is expressed in the cortex of mature roots, and AtNPF2.9, which is expressed in root companion cells where it is involved in phloem loading. NPF1/2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340974 [Multi-domain]  Cd Length: 444  Bit Score: 83.08  E-value: 6.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  43 ELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLGTALLSMLA 122
Cdd:cd17416    8 ETGEKLASYGLLANLIVYLIEEYNMKSIAAANIINIWSGTTNFLPVVGAFLSDSYFGRFPTISVGSFASLLGMVLLTLTA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 123 F-------PAENfyrgAYPVFNNTSVEeQAGLFHVALLTLCLGTGGIRAVVCP--------PDMCGSQERESkkpmpFCN 187
Cdd:cd17416   88 AipslrppPCET----ASSLCQSPSKL-QLAVLYSALALLSIGAGGIRPCSLAfgadqfdkKTESGKRGLES-----FFN 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 188 WASWSANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVTLYLKhcDLIYRPENRCSLLTIarafvralktrclpyc 267
Cdd:cd17416  158 WYYFTFTVAQIISLTAIVYIQDNVSWKIGFGIPAALMLLSFILFLAG--SRLYVVEDLKSLIRV---------------- 219
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 268 hfgrdgsswldhamekqgghhselqeedtrnisalLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGG-FSLPIALMNA 346
Cdd:cd17416  220 -----------------------------------IPIWSTGIILSLAMAQQMSLTVLQALVMDRHLGPsFQIPAGSITV 264
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 347 ISLLPLLILPPFMDYFsncLLPSKRD------GPFLSACMIAGNICAASSVAMAGFLEIYR-KLAREQSPSgklfsVSSM 419
Cdd:cd17416  265 FLLITLTIFIPLYDRV---LVPLLRKitgrgrGLTLLQRVGIGIVFSILSMAVAAIVERKRrKTALTQGNG-----TSPM 336
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 420 ACVCLVPQYVLLGVSEVLVNPAVSMVTHRVIP----GASMAFLTLSHGSACFAGAMLIKLLYLISE----GNWFPNTLDK 491
Cdd:cd17416  337 SVLWLVPQLVLMGIAEAFHFIGQIEFFYQEFPesmrSTATSLFSLGMGVASYLSSALISAVHRTTGrgggGSWLPDDINK 416
                        490       500
                 ....*....|....*....|....*...
gi 282847430 492 GNLENFFFVLASLMLLNILGLWRASWRY 519
Cdd:cd17416  417 GRLDYVYWLLAGLGALNLGYFLVCSWRY 444
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
100-481 2.69e-13

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 71.58  E-value: 2.69e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  100 RNKLMYIALsLHFLGTALLSMLAFPAenfyrGAYPVfnntsveeQAGLFHVALLTLCLGTGGIRAvvCPPDMCGSQ--ER 177
Cdd:pfam00854   1 FRTIFLGSI-IYAIGHILLALSAIPS-----LRPPV--------HVALFFIGLALIALGTGGIKP--NVSSFGGDQfeET 64
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  178 ESKKPMPFCNWASWSANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVTLYL-----KHcdliYRPE-------NR 245
Cdd:pfam00854  65 DPRRRSRFFSIFYFSINAGSLISTIITPYLQQNYGYPLGFGLPAVGMIIALLVFLLgsrmyKK----KPPKgnvltkvFK 140
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  246 CSLLTIARAFVRALKTRCLPYCHfgrdgssWLDHAMEKQG--------------GHHSELQEEDTRNISALLPLFSFQIL 311
Cdd:pfam00854 141 VLPVAAWNKVKLNGSSAGIKKLH-------WLDWARELDAliilgivvpgiffnIWCTKTKVEEVKRLLRVLPLFLPLIM 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  312 YRTCLLQIPSGYYLQTMNSNRNWGGFSLPIALMNAISLLPLLILPPFMDYFSNCLLPSKRDGPFLSACMIAGNICAASSV 391
Cdd:pfam00854 214 FWALYDQMGTSWVLQARTMNRKIGSFEIPPAQFQAFNAILVLIFIPIFDRLVYPLGRKCTGGLTPLQKMAVGLFLASLAF 293
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  392 AMAGFLEIYRKLAREQSPSGKLFSVSsmacVC-LVPQYVLLGVSEVLVNP-AVSMVTHRVIP---GASMAFLTLSHGSAC 466
Cdd:pfam00854 294 AIAAIVQLKRNDTGPEFPIAQEVPIS----VLwLIPQYLLIGFGELFISIgGLEFFYKLAPKsmtSLITGLFLLTNALGN 369
                         410
                  ....*....|....*
gi 282847430  467 FAGAMLIKLLYLISE 481
Cdd:pfam00854 370 FLSGVIATLTAKPTN 384
MFS_NPF3 cd17415
NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The ...
43-517 1.92e-12

NRT1/PTR family (NPF), subfamily 3 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. NPF3 is the smallest NPF subfamily and it includes Cucumis sativus nitrite transporter (CsNitr1), now named CsNPF3.2. It functions as a chloroplast nitrite uptake transporter to remove toxic nitrite from the cytosol. NPF3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340973 [Multi-domain]  Cd Length: 448  Bit Score: 69.40  E-value: 1.92e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  43 ELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLG------TA 116
Cdd:cd17415   11 EICERLASVGFHTNLITYLTLQLHMPLVKAANILTNFNGTASLTPLLGAFIADSFAGRFWTITIGSIIYQLGmvlltiSA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 117 LLSMLAFPAENFYRGAYPVFNNTsveeQAGLFHVALLTLCLGTGGIRAVVCP-----PDMcgSQERESKKPMPFCNWASW 191
Cdd:cd17415   91 ILPSLRPPPCNGHEVCACQASSA----QLSILYLSLLLTALGSGGIRPCVVAfgadqFDE--SDPKQAKQTWNFFNWYYF 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 192 SANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVtlylkhcdliyrpenrcslltiarAFVRalktrclpychfgr 271
Cdd:cd17415  165 CMGIAILLAVTVIVYIQDNVGWGWGFGIPTIAMAISVI------------------------AFVV-------------- 206
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 272 dGSSWldhamekqgghHSELqeedtRNISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGG-FSLPIALMNAISLL 350
Cdd:cd17415  207 -GSPL-----------YREL-----KSIIRMLPIWAAGILLVTASSQQHTFSIQQARTMNRHLTPsFQIPPASMSVFGIL 269
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 351 PLLILPPFMDY----FSNCLLPSKRDGPFLSAcMIAGNICAASSVAMAGFLEIYRK-LAREQSPSGKLFSVSSMACVCLV 425
Cdd:cd17415  270 SLLTTVPLYDRvlmpVARKFTGNERGITFLQR-MGIGLFISILATVVAAFVEVKRKsVAANHGLLDRPHATVPISVFWLV 348
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 426 PQYVLLGVSEVLVNPAVSMVTHRVIP------GASMAFLTLSHGSacFAGAMLIKLLYLIS---EGNWFPNTLDKGNLEN 496
Cdd:cd17415  349 PQYILHGIAEAFMSIGHLEFFYDQSPesmrstATALFWSTISLGS--YLSTLLVTLVHKETsrgGRWWLPNNLNRGRLDY 426
                        490       500
                 ....*....|....*....|..
gi 282847430 497 FFFVLASLMLLNIL-GLWRASW 517
Cdd:cd17415  427 FYWLVAVLQAVNLVyFLICARW 448
MFS_NPF4 cd17414
NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The ...
40-518 6.05e-12

NRT1/PTR family (NPF), subfamily 4 of the Major Facilitator Superfamily of transporters; The plant Nitrate transporter/Peptide transporter (NRT1/PTR) family (NPF) is related to the POT (proton-coupled oligopeptide transporter), Peptide transporter (PepT/PTR), or Solute Carrier 15 (SLC15) family in animals. In contrast to related animal and bacterial counterparts, the plant proteins transport a wide variety of substrates including nitrate, peptides, amino acids, dicarboxylates, glucosinolates, as well as the plant hormones indole-3-acetic acid (IAA) and abscisic acid (ABA). A recent study identified eight subfamilies within this family, named NPF1-NPF8. Members of the NPF4 subfamily have been shown to transport ABA. NPF4 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340972 [Multi-domain]  Cd Length: 456  Bit Score: 67.82  E-value: 6.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  40 LLVELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLGTALLS 119
Cdd:cd17414    8 LVVEALENMAYLANANNLVTYLINNMHYSLAKSANIVTNFVGTAFLLALLGGFLSDSFLSSFKTIIIFGSIELLGLILLT 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 120 MLAFPAENFYRGAYPVFNNTSVE---EQAGLFHVALLTLCLGTGGIRAVVcpPDMCGSQ-----ERESKKPMPFCNWASW 191
Cdd:cd17414   88 VQAHIPSLQPPSCNSLGDLTCKEpsgSQAAILFVGLYLVALGVGCIKPNL--PSHGADQfdendPKGRRQLSSFFNWYYF 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 192 SANLNAAVVFLGISSIQPLGSGALGILLPSLSVFTALVTLylkhcdliyrpenrcslltIARAFVRALKTrclpychfgr 271
Cdd:cd17414  166 SFSLGALIAVTLVVWVEENKGWDWGFGVSAAVIAVGILVF-------------------VAGTPFYRNKT---------- 216
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 272 dgsswldhamekqgghhselQEEDTRNISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGG-FSLPIALMNAISLL 350
Cdd:cd17414  217 --------------------QVEEVKIVLKMLPIFACTIILNCILAQLQTFSVQQGSTMNRTKIGsFNIPPASLQAIPVI 276
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 351 PLLILPPFMDYFSNCLL-----------PSKRDGPFLSACMIagnicaasSVAMAGFLEIYRK-LAREQSPSGKLFSVsS 418
Cdd:cd17414  277 FMLILVPLYDHLLVPFArkitghesgitHLQRIGIGLVLSTL--------SMVVAALVETKRKkVAVENGLLNSKENL-P 347
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 419 MACVCLVPQYVLLGVSEVLVnpAVSMVT--HRVIPGASMAFLT----LSHGSACFAGAMLIKLLYLI-----SEGNWFPN 487
Cdd:cd17414  348 ISIFWIALQFLILGISDMFT--AVGLLEffYTESPSSMRSLGTaltwCSYSFGFYLSSVLVSVVNKVtgsggHGGWLLGE 425
                        490       500       510
                 ....*....|....*....|....*....|.
gi 282847430 488 TLDKGNLENFFFVLASLMLLNILGLWRASWR 518
Cdd:cd17414  426 NLNRDRLDLFYWLLCVLSTINFLNYLFWARR 456
PTR2 COG3104
Dipeptide/tripeptide permease [Amino acid transport and metabolism];
39-485 8.70e-09

Dipeptide/tripeptide permease [Amino acid transport and metabolism];


Pssm-ID: 225646 [Multi-domain]  Cd Length: 498  Bit Score: 58.06  E-value: 8.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  39 LLLVELCERFTFFEVVCNMIPFCTGRLG---SYNHQAAMLNLGFIGTSV-LTPVFMGWLADEYFGRNKLMYIALSLHFLG 114
Cdd:COG3104   26 IFFVELWERFSYYGMRAILILYLYYQLGdglGFDETHATGLFSAYGSLVyLTPIIGGWLADRVLGTRRTIVLGAILMAIG 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 115 TALLSMLAFPAenfyrgaypvfnntsveeqAGLFHVALLTLCLGTGGIRAvvCPPDMCGSQ--ERESKKPMPFcnwasws 192
Cdd:COG3104  106 HLVLAISSVSG-------------------PGGLYIGLALIIVGTGLFKP--NISSLLGELypKDDPRRDGGF------- 157
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 193 aNLNAAVVFLGiSSIQPLGSGALGILLPSLSVFTA---------LVTLYLKHCDLIYRPENRCSLLT--IARAFVRALKT 261
Cdd:COG3104  158 -TLFYMGINIG-SLIAPIITGLLAINYGWHVGFGLaavgmiiglVIFLLGRRHVKGIGGVPDPNPLSfnFLLPVLGGLVV 235
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 262 RCLPYCHFGRDGSSWLDHAMEKQGGHH----------SELQEEDTRNISALLPLFSFQILYRTCLLQIPSGYYLQ-TMNS 330
Cdd:COG3104  236 MILAALLTLLLNQNTFSGVLLVISILIaiiyfaeafrSPKVFDERRRLLAAIPLFLFAVIFWALYEQMGSSLNLYaDRNV 315
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 331 NRNWGGFSLPIALMNAISLLPLLILPPFMDYFSNCLLPSKRDgPFLSACMIAGNICAASSVAMAGFLEIYRKLareqsPS 410
Cdd:COG3104  316 NRQIFGFEVPPAWFQSLNPFFIILFSPILAALWTKLGRGNKQ-PSTPIKFALGLILAGLGFLILLLAGIWFGG-----PS 389
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 411 GKLfSVSSMacvclVPQYVLLGVSEVLVNP-AVSMVTHRVIPG-----ASMAFLTLSHG---SACFAG--AMLIKLLYLI 479
Cdd:COG3104  390 GLV-SVWWL-----VLSYVLQSFGELFISPvGLSMVTKLAPPAlksfiMAMWFLTVAAGqtlGGQVAGltAVTDPAYTAF 463

                 ....*.
gi 282847430 480 SEGNWF 485
Cdd:COG3104  464 IEGRVF 469
MFS_SLC15A1_2_like cd17347
Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily ...
43-438 2.34e-07

Solute carrier family 15 members 1 and 2, and similar Major Facilitator Superfamily transporters; Solute carrier family 15 member 1 (SLC15A1) and SLC15A2 are members of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. They mediate the proton-coupled active transport of a broad range of dipeptides and tripeptides, including zwitterionic, anionic and cationic peptides, as well as a variety of peptide-like drugs such as cefadroxil, enalapril, and valacyclovir. SLC15A1, or peptide transporter 1 (PepT1), is primarily expressed in the brush border membranes of enterocytes of the small intestine and is also known as the intestinal isoform. SLC15A2, or peptide transporter 2 (PepT2), is abundantly expressed in the apical membrane of kidney proximal tubules and is also referred to as the renal isoform. Both proteins transport di/tripeptides, but not tetrapeptides or free amino acids, using the energy generated by an inwardly directed transmembrane proton gradient. The SLC15A1/SLC15A2-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340905 [Multi-domain]  Cd Length: 427  Bit Score: 53.39  E-value: 2.34e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  43 ELCERFTFFEVVCNMIPFCTGRLGSYNHQAAMLNLGFIGTSVLTPVFMGWLADEYFGRNKLMYIALSLHFLGTALLSMLA 122
Cdd:cd17347   11 EFCERFSYYGMRAILVLYLTDFLGFSEAEATAIYHSFVMLCYFFPLLGAIIADSYLGKYRTILYLSLVYCLGHIVLAVTA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 123 FPAenfyrgaypvfnnTSVEEQAGLFhVALLTLCLGTGGIRAVVCPpdMCGSQERESKKPM--PFCNWASWSANlnaavv 200
Cdd:cd17347   91 IPP-------------LGPPHVWGLL-IGLLLIAIGTGGIKPCVSA--FGGDQFGADQQHLlaRFFSWFYFAIN------ 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 201 flgissiqpLGSGALGILLPslsvftalvtlylkhcdliyrpenrcslltIARAFVRALKTRCLPYChFGRDGSS----- 275
Cdd:cd17347  149 ---------AGSLLSTFLTP------------------------------ILRADVQFGGHDCYPLA-FGVPGVLmavat 188
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 276 ---WLDHAMEKqgghhselqeeDTRNISALLPLFSFQILYRTCLLQIPSGYYLQTMNSNRNWGGFSLPIALMNAISLLPL 352
Cdd:cd17347  189 lvfWLGRKHYK-----------DVKALLRVLVLFIPLPVFWALFDQQGSRWTLQAEQMDGLVGGFTILPDQMQALNPILI 257
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430 353 LILPPFMDYFSNcllpskrdgPFLSAC---------MIAGNICAASSVAMAGFLEIYRKLAREQSPSGK---LFSVSSMA 420
Cdd:cd17347  258 LILIPLFDYVIY---------PLLERCgipltplrkMGVGMILAALAFVIAGFLQLRIDGGLPGQPDPGevtTFEDIEPN 328
                        410       420
                 ....*....|....*....|.
gi 282847430 421 CVCL---VPQYVLLGVSEVLV 438
Cdd:cd17347  329 SVSIlwqLPQYVVLTAGEVLF 349
MFS_PTR2 cd17350
Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide ...
29-168 6.22e-07

Peptide transporter PTR2 of the Major Facilitator Superfamily of transporters; Fungal peptide transporter or permease PTR2 is a member of the proton-coupled oligopeptide transporter (POT) family of integral membrane proteins that mediate the cellular uptake of di/tripeptides and peptide-like drugs. It is a 12-transmembrane domain (TMD) integral membrane protein that translocates di-/tripeptides. As with other POT family proteins, it displays characteristic substrate multispecificity. PTR2 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340908 [Multi-domain]  Cd Length: 438  Bit Score: 52.09  E-value: 6.22e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 282847430  29 PYGCFRVGIClllvELCERFTFFEVvcnmipfcTGRLGSY------NHQAAMLNLGFIGTSVL----------TPVFMGW 92
Cdd:cd17350    1 PWSAFLIAIV----ELCERFSYYGL--------TGPFQNYmqfgpdDSTPGALGLGEQGATGLsnfftfwcyvTPVIGAY 68
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 282847430  93 LADEYFGRNKLMYIALSLHFLGTALLSMLAFPaenfyrgaypvfnnTSVEEQAGL--FHVALLTLCLGTGGIRAVVCP 168
Cdd:cd17350   69 VADQFLGRYNTIVCGAVIYFVGILILTCTSIP--------------SVIDAGAGLggFVVAIIIIGLGTGGIKSNVSP 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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