NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|46559434|ref|NP_808587|]
View 

transcription elongation factor A protein-like 5 [Mus musculus]

Protein Classification

BEX domain-containing protein( domain architecture ID 10517751)

BEX domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
80-174 3.72e-21

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


:

Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 83.46  E-value: 3.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434    80 ESKPDSQAKSASEAraaEKRPAEDYVPRKAKRKTDRG-TDDSPKNSQEDLQDRHVSSEEMMRECADMTRAQEELRK-RQK 157
Cdd:pfam04538   9 EGKPEEQGKVENEE---EPEDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEEMMREGDDMERFGEEMRElRQK 85
                          90
                  ....*....|....*..
gi 46559434   158 MGGFHWVPRDAQDALVP 174
Cdd:pfam04538  86 LREQQWRQRPHRDHHYP 102
2A1904 super family cl36772
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
6-151 9.16e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00927:

Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 51.53  E-value: 9.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434      6 KENEGKPENKGRAEDEGSTE-EGGKADEDKSDAEGKPA------------RQGKLEVEGGPGEQAQQKGEGKPEK--QGK 70
Cdd:TIGR00927  667 AEQEGETETKGENESEGEIPaERKGEQEGEGEIEAKEAdhkgeteaeeveHEGETEAEGTEDEGEIETGEEGEEVedEGE 746
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434     71 SDGEGKRQGESKPDSQAKSASEARAAEKRPAED----YVPRKAKRKTDRGTDDSPKNSQEDLQDRHVSSEEMMRECADMT 146
Cdd:TIGR00927  747 GEAEGKHEVETEGDRKETEHEGETEAEGKEDEDegeiQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDT 826

                   ....*
gi 46559434    147 RAQEE 151
Cdd:TIGR00927  827 EVKDE 831
 
Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
80-174 3.72e-21

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 83.46  E-value: 3.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434    80 ESKPDSQAKSASEAraaEKRPAEDYVPRKAKRKTDRG-TDDSPKNSQEDLQDRHVSSEEMMRECADMTRAQEELRK-RQK 157
Cdd:pfam04538   9 EGKPEEQGKVENEE---EPEDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEEMMREGDDMERFGEEMRElRQK 85
                          90
                  ....*....|....*..
gi 46559434   158 MGGFHWVPRDAQDALVP 174
Cdd:pfam04538  86 LREQQWRQRPHRDHHYP 102
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
6-151 9.16e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 51.53  E-value: 9.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434      6 KENEGKPENKGRAEDEGSTE-EGGKADEDKSDAEGKPA------------RQGKLEVEGGPGEQAQQKGEGKPEK--QGK 70
Cdd:TIGR00927  667 AEQEGETETKGENESEGEIPaERKGEQEGEGEIEAKEAdhkgeteaeeveHEGETEAEGTEDEGEIETGEEGEEVedEGE 746
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434     71 SDGEGKRQGESKPDSQAKSASEARAAEKRPAED----YVPRKAKRKTDRGTDDSPKNSQEDLQDRHVSSEEMMRECADMT 146
Cdd:TIGR00927  747 GEAEGKHEVETEGDRKETEHEGETEAEGKEDEDegeiQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDT 826

                   ....*
gi 46559434    147 RAQEE 151
Cdd:TIGR00927  827 EVKDE 831
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
31-126 4.53e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.44  E-value: 4.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434   31 DEDKSDAEGKPAR--QGKLEVEGGPGEQAQQKGEGKPEKQGKSDGEGKRQGESKPDSQAKSASEARaaEKRPAEdyVPRK 108
Cdd:PTZ00449 500 EEEDSDKHDEPPEgpEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAK--EHKPSK--IPTL 575
                         90
                 ....*....|....*...
gi 46559434  109 AKRKTDRGTDDSPKNSQE 126
Cdd:PTZ00449 576 SKKPEFPKDPKHPKDPEE 593
PTZ00121 PTZ00121
MAEBL; Provisional
5-171 8.07e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 36.66  E-value: 8.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434     5 YKENEGKPENKGRaEDEGSTEEGGKADEDKSDAEGKPARQGKLEVEGGPGEQAQQKGEGKPEKQGKSDGEGKRQGESKPD 84
Cdd:PTZ00121 1076 YKDFDFDAKEDNR-ADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRV 1154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434    85 SQAKSASEARAAE-KRPAEDYVPRKAKRKTDRGTDDSPKNSQEDLQDRHVSSEEMMRECADMTRAQEELRKRQKMGGFHW 163
Cdd:PTZ00121 1155 EIARKAEDARKAEeARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEE 1234

                  ....*...
gi 46559434   164 VPRDAQDA 171
Cdd:PTZ00121 1235 AKKDAEEA 1242
 
Name Accession Description Interval E-value
BEX pfam04538
Brain expressed X-linked like family; This is a family of transcription elongation factors ...
80-174 3.72e-21

Brain expressed X-linked like family; This is a family of transcription elongation factors which includes those referred to as Bex proteins as well as those named TCEAL7. Bex1 was shown to be a novel link between neurotrophin signalling, the cell cycle, and neuronal differentiation, suggesting it might function by coordinating internal cellular states with the ability of cells to respond to external signals. TCEAL7 has been shown negatively to regulate the NF-kappaB pathway, hence being important in ovarian cancer as it one of the genes frequently downregulated in this cancer. A closely related protein, TFIIS/TCEA, found in pfam07500 is involved in transcription elongation and transcript fidelity. TFIIS/TCEA promotes 3' endoribonuclease activity of RNA polymerase II (pol II) and allows pol II to bypass transcript pause or 'arrest' during elongation process. It is thus possible that BEX is also acting in this way.


Pssm-ID: 461346 [Multi-domain]  Cd Length: 103  Bit Score: 83.46  E-value: 3.72e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434    80 ESKPDSQAKSASEAraaEKRPAEDYVPRKAKRKTDRG-TDDSPKNSQEDLQDRHVSSEEMMRECADMTRAQEELRK-RQK 157
Cdd:pfam04538   9 EGKPEEQGKVENEE---EPEDLEGGEPRKPRGNTRRGrVRQSVPNFREDIPNRHLSPEEMMREGDDMERFGEEMRElRQK 85
                          90
                  ....*....|....*..
gi 46559434   158 MGGFHWVPRDAQDALVP 174
Cdd:pfam04538  86 LREQQWRQRPHRDHHYP 102
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
6-151 9.16e-08

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 51.53  E-value: 9.16e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434      6 KENEGKPENKGRAEDEGSTE-EGGKADEDKSDAEGKPA------------RQGKLEVEGGPGEQAQQKGEGKPEK--QGK 70
Cdd:TIGR00927  667 AEQEGETETKGENESEGEIPaERKGEQEGEGEIEAKEAdhkgeteaeeveHEGETEAEGTEDEGEIETGEEGEEVedEGE 746
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434     71 SDGEGKRQGESKPDSQAKSASEARAAEKRPAED----YVPRKAKRKTDRGTDDSPKNSQEDLQDRHVSSEEMMRECADMT 146
Cdd:TIGR00927  747 GEAEGKHEVETEGDRKETEHEGETEAEGKEDEDegeiQAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDT 826

                   ....*
gi 46559434    147 RAQEE 151
Cdd:TIGR00927  827 EVKDE 831
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
31-126 4.53e-04

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.44  E-value: 4.53e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434   31 DEDKSDAEGKPAR--QGKLEVEGGPGEQAQQKGEGKPEKQGKSDGEGKRQGESKPDSQAKSASEARaaEKRPAEdyVPRK 108
Cdd:PTZ00449 500 EEEDSDKHDEPPEgpEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAK--EHKPSK--IPTL 575
                         90
                 ....*....|....*...
gi 46559434  109 AKRKTDRGTDDSPKNSQE 126
Cdd:PTZ00449 576 SKKPEFPKDPKHPKDPEE 593
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
2-137 7.43e-04

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 39.98  E-value: 7.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434      2 EKFYKENEGKPENKgRAEDEGSTEEGGK--ADEDKSDAEGKPArqgkLEVEGGPGEQAQQKGEGKPEKQGKSDGE--GKR 77
Cdd:TIGR00927  713 EEVEHEGETEAEGT-EDEGEIETGEEGEevEDEGEGEAEGKHE----VETEGDRKETEHEGETEAEGKEDEDEGEiqAGE 787
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434     78 QGESKPDSQAKSASEARAAEKRPAEDYVPRKAKRKTDRGTDDSPKNSQEDLQDRHVSSEE 137
Cdd:TIGR00927  788 DGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSETQADDTEVKDETGEQELNAENQGEAKQ 847
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
1-119 1.65e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 38.82  E-value: 1.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434      1 MEKFYKENEGK-PENKGRAEDEGSTEEGGKADE--DKSDAEGKPARQGKLEVEGGPGEQAQQKGEGkpEKQGKSDGEGKR 77
Cdd:TIGR00927  608 IELWVKEQLSRrPVAKVMALGDLSKGDVAEAEHtgERTGEEGERPTEAEGENGEESGGEAEQEGET--ETKGENESEGEI 685
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 46559434     78 QGESKPDSQAKSASEARAAEKRPAEDYVPRKAKRKT-DRGTDD 119
Cdd:TIGR00927  686 PAERKGEQEGEGEIEAKEADHKGETEAEEVEHEGETeAEGTED 728
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
7-103 1.84e-03

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 38.44  E-value: 1.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434      7 ENEGKPENKGRAEDEGSTEEGGKADEDKSDAEGKPA--RQGKLEVEGGPGEQ---AQQKGEGKPEKQGKSDGEGKRQGES 81
Cdd:TIGR00927  784 QAGEDGEMKGDEGAEGKVEHEGETEAGEKDEHEGQSetQADDTEVKDETGEQelnAENQGEAKQDEKGVDGGGGSDGGDS 863
                           90       100
                   ....*....|....*....|..
gi 46559434     82 KPDSQAKSASEARAAEKRPAED 103
Cdd:TIGR00927  864 EEEEEEEEEEEEEEEEEEEEEE 885
PTZ00121 PTZ00121
MAEBL; Provisional
2-156 4.98e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 37.43  E-value: 4.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434     2 EKFYKENEGKPENKGRAEDEGSTEEGGKADEDKSDAEGKPARQGKLEVEGGPGEQAQQKGEGKPEKQgKSDGEGKRQGES 81
Cdd:PTZ00121 1496 KKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEE-KKKAEEAKKAEE 1574
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 46559434    82 KPDSQAKSASEARAAEKRPAEDYVPRKAKRKTDRGtDDSPKNSQEDLQDRHVSSEEMMRECADMTRAQEELRKRQ 156
Cdd:PTZ00121 1575 DKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKA-EEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKK 1648
PTZ00121 PTZ00121
MAEBL; Provisional
5-171 8.07e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 36.66  E-value: 8.07e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434     5 YKENEGKPENKGRaEDEGSTEEGGKADEDKSDAEGKPARQGKLEVEGGPGEQAQQKGEGKPEKQGKSDGEGKRQGESKPD 84
Cdd:PTZ00121 1076 YKDFDFDAKEDNR-ADEATEEAFGKAEEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRV 1154
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 46559434    85 SQAKSASEARAAE-KRPAEDYVPRKAKRKTDRGTDDSPKNSQEDLQDRHVSSEEMMRECADMTRAQEELRKRQKMGGFHW 163
Cdd:PTZ00121 1155 EIARKAEDARKAEeARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARKAEEERKAEEARKAEDAKKAEAVKKAEE 1234

                  ....*...
gi 46559434   164 VPRDAQDA 171
Cdd:PTZ00121 1235 AKKDAEEA 1242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH