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Conserved domains on  [gi|30520165|ref|NP_848848|]
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zinc finger protein 14 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12017129)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development, and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 4.58e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.38  E-value: 4.58e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 30520165     7 LVTFGDVAVDFSQEEWEFLDPAQKNLYRDVMWETYSNFISLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-500 2.25e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 222 KPYECKECGKAFRVHQQLARHQRIHTGEKPYEC--KECGKTFRQCTHLTRHQRLHTSEKLYECK---------------- 283
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 284 ECGKAFVCGPDLrVHQKIHFGEKPY-ACKDCGKSFRICQQLTVHQSIHTGEK-------PYECKECGKTFRLRQQLVRHQ 355
Cdd:COG5048 112 SSSSNSNDNNLL-SSHSLPPSSRDPqLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 356 RIHTHERPYECLECWKTFSSYSQLISHQSIHVGERPYECEECGKAFRLLSQLTQHQSIHTGEKPYECQECRKPFRLLSQL 435
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30520165 436 TQHRSIHTGE-------KPYECKDCGKAFRLYSFLSQHQR--IHTGE--KPYKCKE--CKKAFRQHSHLTQHQKIHSG 500
Cdd:COG5048 271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
182-206 2.80e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.80e-03
                          10        20
                  ....*....|....*....|....*
gi 30520165   182 HLIRHHKLHTGEKPYECKDCGKAFT 206
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 4.58e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.38  E-value: 4.58e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 30520165     7 LVTFGDVAVDFSQEEWEFLDPAQKNLYRDVMWETYSNFISLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
8-50 2.01e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 90.34  E-value: 2.01e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 30520165      8 VTFGDVAVDFSQEEWEFLDPAQKNLYRDVMWETYSNFISLDLE 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 3.62e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 80.67  E-value: 3.62e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 30520165   8 VTFGDVAVDFSQEEWEFLDPAQKNLYRDVMWETYSNFISL 47
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-500 2.25e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 222 KPYECKECGKAFRVHQQLARHQRIHTGEKPYEC--KECGKTFRQCTHLTRHQRLHTSEKLYECK---------------- 283
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 284 ECGKAFVCGPDLrVHQKIHFGEKPY-ACKDCGKSFRICQQLTVHQSIHTGEK-------PYECKECGKTFRLRQQLVRHQ 355
Cdd:COG5048 112 SSSSNSNDNNLL-SSHSLPPSSRDPqLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 356 RIHTHERPYECLECWKTFSSYSQLISHQSIHVGERPYECEECGKAFRLLSQLTQHQSIHTGEKPYECQECRKPFRLLSQL 435
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30520165 436 TQHRSIHTGE-------KPYECKDCGKAFRLYSFLSQHQR--IHTGE--KPYKCKE--CKKAFRQHSHLTQHQKIHSG 500
Cdd:COG5048 271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
zf-H2C2_2 pfam13465
Zinc-finger double domain;
239-263 1.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.96e-04
                          10        20
                  ....*....|....*....|....*
gi 30520165   239 LARHQRIHTGEKPYECKECGKTFRQ 263
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
182-206 2.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.80e-03
                          10        20
                  ....*....|....*....|....*
gi 30520165   182 HLIRHHKLHTGEKPYECKDCGKAFT 206
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 7-48 4.58e-23

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 91.38  E-value: 4.58e-23
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 30520165     7 LVTFGDVAVDFSQEEWEFLDPAQKNLYRDVMWETYSNFISLD 48
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
8-50 2.01e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 90.34  E-value: 2.01e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 30520165      8 VTFGDVAVDFSQEEWEFLDPAQKNLYRDVMWETYSNFISLDLE 50
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 8-47 3.62e-19

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 80.67  E-value: 3.62e-19
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 30520165   8 VTFGDVAVDFSQEEWEFLDPAQKNLYRDVMWETYSNFISL 47
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-500 2.25e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.24  E-value: 2.25e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 222 KPYECKECGKAFRVHQQLARHQRIHTGEKPYEC--KECGKTFRQCTHLTRHQRLHTSEKLYECK---------------- 283
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 284 ECGKAFVCGPDLrVHQKIHFGEKPY-ACKDCGKSFRICQQLTVHQSIHTGEK-------PYECKECGKTFRLRQQLVRHQ 355
Cdd:COG5048 112 SSSSNSNDNNLL-SSHSLPPSSRDPqLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpPLPANSLSKDPSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 356 RIHTHERPYECLECWKTFSSYSQLISHQSIHVGERPYECEECGKAFRLLSQLTQHQSIHTGEKPYECQECRKPFRLLSQL 435
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 30520165 436 TQHRSIHTGE-------KPYECKDCGKAFRLYSFLSQHQR--IHTGE--KPYKCKE--CKKAFRQHSHLTQHQKIHSG 500
Cdd:COG5048 271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-442 2.02e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 53.16  E-value: 2.02e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 158 HLRIHTGEKPYKCKECGQPFRQRAHLIRHHKLHTGEKPYECKDCGkaFTVLQELTQHQRLHTGEK--PYECKECGKAFR- 234
Cdd:COG5048 189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNS--QLSPKSLLSQSPSSLSSSdsSSSASESPRSSLp 266

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 235 -VHQQLARHQRIHTGE-----KPYECKECGKTFRQCTHLTRHQR--LHTSEKLYECKE----CGKAFVCGPDLRVHQKIH 302
Cdd:COG5048 267 tASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFSCpyslCGKLFSRNDALKRHILLH 346

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 303 FGEKPYACKdcgksfricqqLTVHQSIHTGEKPYEckecgktfrlRQQLVRHQRIHTHERPYECL--ECWKTFSSYSQLI 380
Cdd:COG5048 347 TSISPAKEK-----------LLNSSSKFSPLLNNE----------PPQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLS 405

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 30520165 381 SHQSIHVGERPYECE--ECGKAFRLLSQLTQHQSIHTGEKPYECQECRKPFRllSQLTQHRSIH 442
Cdd:COG5048 406 LHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRR--DLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-499 3.07e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.78  E-value: 3.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 166 KPYKCKECGQPFRQRAHLIRHHKLHTGEKPYECKD--CGKAFTVLQELTQHQRLHTGEKPYECK---------------- 227
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkslplsnskassssls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 228 ECGKAFRVHQQLA--------RHQRIHTGEKPYE--------CKECGKTFRQCTHL---TRHQRLHTSEKLYECKECGKA 288
Cdd:COG5048 112 SSSSNSNDNNLLSshslppssRDPQLPDLLSISNlrnnplpgNNSSSVNTPQSNSLhppLPANSLSKDPSSNLSLLISSN 191

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 289 FVCGPD------LRVHQKI-------HFGEKPYACKDCGKSFRICQQLTVHQSIHTGEKPYECKECGKTFRLRQQLVRHQ 355
Cdd:COG5048 192 VSTSIPsssensPLSSSYSipssssdQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQ 271

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 356 RIH-------THER---PYECLECWKTFSSYSQLISHQ--SIHVGE--RPYECEE--CGKAFRLLSQLTQHQSIHTGEKP 419
Cdd:COG5048 272 SSSpnesdssSEKGfslPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISP 351

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 420 YEC--QECRKPFRLLS-----QLTQHRSIHTGEKPYEC--KDCGKAFRLYSFLSQHQRIHTGEKP--YKCKECKKAFRQH 488
Cdd:COG5048 352 AKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                       410
                ....*....|.
gi 30520165 489 SHLTQHQKIHS 499
Cdd:COG5048 432 YNLIPHKKIHT 442
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 332-410 4.04e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 45.86  E-value: 4.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 332 GEKPYECK--ECGKTFRlRQQLVRHQRIHTHERPyeclecwKTFSSYSQlISHQSIHVGERPYECEECGKAFRLLSQLTQ 409
Cdd:COG5189 346 DGKPYKCPveGCNKKYK-NQNGLKYHMLHGHQNQ-------KLHENPSP-EKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                .
gi 30520165 410 H 410
Cdd:COG5189 417 H 417
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
334-491 5.81e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 5.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 334 KPYECKECGKTFRLRQQLVRHQRIHTHE----RPYECLE--CWKTFSSYSQLISHQSIHVGERPYEC--EECGKAFRLLS 405
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRSVNHSgeslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 30520165 406 -----QLTQHQSIHTGEKPYEC--QECRKPFRLLSQLTQHRSIHTGEKPYECKD--CGKAFRLYSFLSQHQRIHTGEKPY 476
Cdd:COG5048 368 nneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNppCSKSFNRHYNLIPHKKIHTNHAPL 447

                       170
                ....*....|....*
gi 30520165 477 KCkECKKAFRQHSHL 491
Cdd:COG5048 448 LC-SILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
239-263 1.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.96e-04
                          10        20
                  ....*....|....*....|....*
gi 30520165   239 LARHQRIHTGEKPYECKECGKTFRQ 263
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
463-487 5.94e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.94e-04
                          10        20
                  ....*....|....*....|....*
gi 30520165   463 LSQHQRIHTGEKPYKCKECKKAFRQ 487
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
210-233 1.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.31e-03
                          10        20
                  ....*....|....*....|....
gi 30520165   210 ELTQHQRLHTGEKPYECKECGKAF 233
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
182-206 2.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.80e-03
                          10        20
                  ....*....|....*....|....*
gi 30520165   182 HLIRHHKLHTGEKPYECKDCGKAFT 206
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 252-274 4.56e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.56e-03
                          10        20
                  ....*....|....*....|...
gi 30520165   252 YECKECGKTFRQCTHLTRHQRLH 274
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-317 6.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.98e-03
                          10        20
                  ....*....|....*....|....
gi 30520165   294 DLRVHQKIHFGEKPYACKDCGKSF 317
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
266-291 8.17e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.17e-03
                          10        20
                  ....*....|....*....|....*.
gi 30520165   266 HLTRHQRLHTSEKLYECKECGKAFVC 291
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 476-498 8.80e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 8.80e-03
                          10        20
                  ....*....|....*....|...
gi 30520165   476 YKCKECKKAFRQHSHLTQHQKIH 498
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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