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Conserved domains on  [gi|110665716|ref|NP_849206|]
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KRAB zinc finger protein isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016931)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 6.61e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.44  E-value: 6.61e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 110665716    4 VTYEDVHVNFTQEEWALLDPSQKKLYKDVMVETYRNLNAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-293 1.86e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 1.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 130 QKPYECNQCGKGFRMPSCLKRHER--IHTGE--KPYEC--NQCGKGFITPSHLKRHERIHTGEKPYKC--NQCDKAFSQ- 200
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPl 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 201 ---YVHLQIH-RSTHTGEKPFKCD--ECDKAFSKHFHLQNHKRTHTGEKPY--KCNQCNKAFSQHTNLHIHRRTHTGEKP 272
Cdd:COG5048  367 lnnEPPQSLQqYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170       180
                 ....*....|....*....|.
gi 110665716 273 FkCNECDKVFSQFGHLQIHIK 293
Cdd:COG5048  447 L-LCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
315-340 2.44e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.44e-04
                          10        20
                  ....*....|....*....|....*.
gi 110665716  315 SLQTHIRIHTGEKPYKCNQCDKAFSQ 340
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
298-352 4.70e-04

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 4.70e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 110665716 298 DKPYKCNQCNKAFYQKRSLQTHIRIHTGEKPYKCNQ--CDKAFSQYGHLYIHRRIHT 352
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 6.61e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.44  E-value: 6.61e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 110665716    4 VTYEDVHVNFTQEEWALLDPSQKKLYKDVMVETYRNLNAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 1.88e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 78.02  E-value: 1.88e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 110665716     4 VTYEDVHVNFTQEEWALLDPSQKKLYKDVMVETYRNLNAIGF 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 5.85e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.43  E-value: 5.85e-18
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 110665716   4 VTYEDVHVNFTQEEWALLDPSQKKLYKDVMVETYRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-293 1.86e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 1.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 130 QKPYECNQCGKGFRMPSCLKRHER--IHTGE--KPYEC--NQCGKGFITPSHLKRHERIHTGEKPYKC--NQCDKAFSQ- 200
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPl 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 201 ---YVHLQIH-RSTHTGEKPFKCD--ECDKAFSKHFHLQNHKRTHTGEKPY--KCNQCNKAFSQHTNLHIHRRTHTGEKP 272
Cdd:COG5048  367 lnnEPPQSLQqYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170       180
                 ....*....|....*....|.
gi 110665716 273 FkCNECDKVFSQFGHLQIHIK 293
Cdd:COG5048  447 L-LCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
175-200 4.74e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 4.74e-05
                          10        20
                  ....*....|....*....|....*.
gi 110665716  175 HLKRHERIHTGEKPYKCNQCDKAFSQ 200
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
315-340 2.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.44e-04
                          10        20
                  ....*....|....*....|....*.
gi 110665716  315 SLQTHIRIHTGEKPYKCNQCDKAFSQ 340
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
298-352 4.70e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 4.70e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 110665716 298 DKPYKCNQCNKAFYQKRSLQTHIRIHTGEKPYKCNQ--CDKAFSQYGHLYIHRRIHT 352
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 243-294 1.62e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 1.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 110665716 243 KPYkCNQCNKAFSQHTNLHIHRRTHTgekpFKCNECDKVFSQFGHLQIHIKT 294
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-312 5.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 5.59e-03
                          10        20
                  ....*....|....*....|....*.
gi 110665716  287 HLQIHIKTHTGDKPYKCNQCNKAFYQ 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 242-348 6.20e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.16  E-value: 6.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 242 EKPYKCNQCNKAFSQHTNLHIH---RRTHT-GEKPFKCN--ECDKVF-SQFGhLQIHIKThtgdkpykcNQCNKAFYQKR 314
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYkNQNG-LKYHMLH---------GHQNQKLHENP 384

                         90       100       110
                 ....*....|....*....|....*....|....
gi 110665716 315 SLQTHIRIHTGEKPYKCNQCDKAFSQYGHLYIHR 348
Cdd:COG5189  385 SPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 6.61e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.44  E-value: 6.61e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 110665716    4 VTYEDVHVNFTQEEWALLDPSQKKLYKDVMVETYRNLNAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 1.88e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 78.02  E-value: 1.88e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 110665716     4 VTYEDVHVNFTQEEWALLDPSQKKLYKDVMVETYRNLNAIGF 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 5.85e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.43  E-value: 5.85e-18
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 110665716   4 VTYEDVHVNFTQEEWALLDPSQKKLYKDVMVETYRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-293 1.86e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 1.86e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 130 QKPYECNQCGKGFRMPSCLKRHER--IHTGE--KPYEC--NQCGKGFITPSHLKRHERIHTGEKPYKC--NQCDKAFSQ- 200
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPl 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 201 ---YVHLQIH-RSTHTGEKPFKCD--ECDKAFSKHFHLQNHKRTHTGEKPY--KCNQCNKAFSQHTNLHIHRRTHTGEKP 272
Cdd:COG5048  367 lnnEPPQSLQqYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYncKNPPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170       180
                 ....*....|....*....|.
gi 110665716 273 FkCNECDKVFSQFGHLQIHIK 293
Cdd:COG5048  447 L-LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
123-353 4.70e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.15  E-value: 4.70e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 123 HKRTQTGQKPYECNQ--CGKGFRMPSCLKRHERIHTGEKPYECN-QCGKGFITPSHLKRHERIHTGEKPYKCNQCDKAFS 199
Cdd:COG5048   52 HIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPS 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 200 QYV--------------------------------------------------HLQIHRSTHTGEKPFKCDECDKAFSKH 229
Cdd:COG5048  132 SRDpqlpdllsisnlrnnplpgnnsssvntpqsnslhpplpanslskdpssnlSLLISSNVSTSIPSSSENSPLSSSYSI 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 230 FHLQNHKRTHTGEKPYKCNQCNKAFSQHTNLHIHRRTHTGEKPFKCNEC------DKVFSQFGHLQIHIKTHTG-DKPYK 302
Cdd:COG5048  212 PSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESprsslpTASSQSSSPNESDSSSEKGfSLPIK 291

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 110665716 303 CNQCNKAFYQKRSLQTHIR--IHTGE--KPYKC--NQCDKAFSQYGHLYIHRRIHTG 353
Cdd:COG5048  292 SKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTS 348
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
151-313 6.30e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.77  E-value: 6.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 151 HERIHTGEKPYECNQCGKGFITPSHLKRHERIHTGEKPYKCNQCDKAFSQYVHLQIHRSTHTGEKPFKCDECDKAF--SK 228
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTA 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 229 HFHLQNHKRTHTGE-----KPYKCNQCNKAFSQHTNLHIHRRT--HTGE--KPFKCNE--CDKVFSQFGHLQIHIKTHTG 297
Cdd:COG5048  269 SSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        170
                 ....*....|....*...
gi 110665716 298 DKPYKC--NQCNKAFYQK 313
Cdd:COG5048  349 ISPAKEklLNSSSKFSPL 366
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
159-312 2.06e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.23  E-value: 2.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 159 KPYECNQCGKGFITPSHLKRHER--IHTGE--KPYKC--NQCDKAFSQYVHLQIHRSTHTGEKPFKCDECD-------KA 225
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 226 FSKHFHLQNHKRTHTGEKPYKC--NQCNKAFSQHTNLHIHRRTHTGEKP--FKCNECDKVFSQFGHLQIHIKTHTGDKPY 301
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|.
gi 110665716 302 KCNQCNKAFYQ 312
Cdd:COG5048  448 LCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
175-200 4.74e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 4.74e-05
                          10        20
                  ....*....|....*....|....*.
gi 110665716  175 HLKRHERIHTGEKPYKCNQCDKAFSQ 200
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-341 8.98e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 8.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 227 SKHFHLQNHKRthtgekPYKCNQCNKAFSQHTNLHIHRRTHTGEKPFKCN--ECDKVFSQFGHLQIHIKTHTGDKPYKCN 304
Cdd:COG5048   22 STLKSLSNAPR------PDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNS 95

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 110665716 305 QCNKAFYQKRSLQTHIRIHTGE-KPYKCNQCDKAFSQY 341
Cdd:COG5048   96 KSLPLSNSKASSSSLSSSSSNSnDNNLLSSHSLPPSSR 133
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
215-307 2.24e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 2.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 215 KPFKCDECDKAFSKHFHLQNHKRTHTGEKPYKCNQ--CNKAFSQHTNLHIHRRTHTGEKPFKCN-ECDKVFSQFGHLQIH 291
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90
                 ....*....|....*.
gi 110665716 292 IKTHTGDKPYKCNQCN 307
Cdd:COG5048  112 SSSSNSNDNNLLSSHS 127
zf-H2C2_2 pfam13465
Zinc-finger double domain;
315-340 2.44e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 2.44e-04
                          10        20
                  ....*....|....*....|....*.
gi 110665716  315 SLQTHIRIHTGEKPYKCNQCDKAFSQ 340
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
130-334 3.13e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 3.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 130 QKPYECNQCGKGFRMPSCLKRHERIHTGEKPYECNQ--CGKGFITPSHLKRHERIHTGEKPYKCNQCDKAFSQY-VHLQI 206
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKaSSSSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 207 HRSTHTGEKPFKCDECDKAFSKHFHLQNHKRTHTGEKPYKCNQCN---KAFSQHTNL-HIHRRTHTGEKPFKCNecdkvf 282
Cdd:COG5048  111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNsssVNTPQSNSLhPPLPANSLSKDPSSNL------ 184

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 110665716 283 sqfgHLQIHIKTHTGDKPYKCNQCNKAFYQKRSLQTHIRIHTGEKPYKCNQC 334
Cdd:COG5048  185 ----SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN 232
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
298-352 4.70e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.99  E-value: 4.70e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 110665716 298 DKPYKCNQCNKAFYQKRSLQTHIRIHTGEKPYKCNQ--CDKAFSQYGHLYIHRRIHT 352
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
231-256 5.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 5.50e-04
                          10        20
                  ....*....|....*....|....*.
gi 110665716  231 HLQNHKRTHTGEKPYKCNQCNKAFSQ 256
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
148-172 6.63e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 6.63e-04
                          10        20
                  ....*....|....*....|....*
gi 110665716  148 LKRHERIHTGEKPYECNQCGKGFIT 172
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 243-294 1.62e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 1.62e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 110665716 243 KPYkCNQCNKAFSQHTNLHIHRRTHTgekpFKCNECDKVFSQFGHLQIHIKT 294
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLQ 47
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 213-296 4.97e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.55  E-value: 4.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 213 GEKPFKCD--ECDKAFSKHFHLQNHKrthtgekpyKCNQCNKAFSQHTNLHIHRRTHTGEKPFKCNECDKVFSQFGHLQI 290
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHM---------LHGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 110665716 291 HIKTHT 296
Cdd:COG5189  417 HRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
203-228 5.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.16e-03
                          10        20
                  ....*....|....*....|....*.
gi 110665716  203 HLQIHRSTHTGEKPFKCDECDKAFSK 228
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
287-312 5.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 5.59e-03
                          10        20
                  ....*....|....*....|....*.
gi 110665716  287 HLQIHIKTHTGDKPYKCNQCNKAFYQ 312
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 242-348 6.20e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 38.16  E-value: 6.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 110665716 242 EKPYKCNQCNKAFSQHTNLHIH---RRTHT-GEKPFKCN--ECDKVF-SQFGhLQIHIKThtgdkpykcNQCNKAFYQKR 314
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERNIDtpsRMLKVkDGKPYKCPveGCNKKYkNQNG-LKYHMLH---------GHQNQKLHENP 384

                         90       100       110
                 ....*....|....*....|....*....|....
gi 110665716 315 SLQTHIRIHTGEKPYKCNQCDKAFSQYGHLYIHR 348
Cdd:COG5189  385 SPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
263-284 7.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.50  E-value: 7.50e-03
                          10        20
                  ....*....|....*....|..
gi 110665716  263 HRRTHTGEKPFKCNECDKVFSQ 284
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 271-319 9.68e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 34.84  E-value: 9.68e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 110665716 271 KPFkCNECDKVFSQFGHLQIHIKTHTgdkpYKCNQCNKAFYQKRSLQTH 319
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVH 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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