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Conserved domains on  [gi|225543361|ref|NP_852087|]
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polycystin-2-like protein 1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
147-567 0e+00

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


:

Pssm-ID: 400395  Cd Length: 424  Bit Score: 570.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  147 SFQTISSMSDFWDFAQGPLLDSLYwtkwyNNQSLGRGSHSFIYYENLLLGAPRLRQLRVRNDSCVVHEDFREDILNCYDV 226
Cdd:pfam08016   1 GLLTVTDLDDIWDWLSSVLLPALH-----SNKTPSGLPGSFIAYESLLLGVPRLRQLRVRNSSCLVPDKFVREINECHAG 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  227 YSPDKEDQ--------LPFGPQNGTAWTYHSQNELGGSSHWGRLTSYSGGGYYLDLPGSRQASAEALQGLQEGLWLDRGT 298
Cdd:pfam08016  76 YSPPSEDRkiysalpyKPVHYTSKYWWIYTPPGLLMGYDHWGYLASYPSGGYVVLLPSSREESLKRLAYLQDNNWLDRGT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  299 RVVFIDFSVYNANINLFCILRLVVEFPATGGTIPSWQIRTVKLIRYVNNWDFFIVGCEVVFCVFIFYYVVEEILEIHLHR 378
Cdd:pfam08016 156 RAVFVDFTLYNADINLFCVVTLRVEFPPTGGVLPSPSVQSVKLLRYVTNRSLFILLCEIVFVVFFLYFVVEEILKIRKHR 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  379 LRYLSSVWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPDTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYIS 458
Cdd:pfam08016 236 PSYLRSVWNLLDLAIVILSVVLIVLNIYRDFLVDRLIKSVEASPVTFIDFDRVAQLDNLYRIILAFLVFLTWLKLFKVLR 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  459 FNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVENFSTFVKCIFTQFRIILGDFDYNAIDNANRILGP 538
Cdd:pfam08016 316 FNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQAPNFSNFVKSILTLFRTILGDFGYNEIFSGNRVLGP 395
                         410       420
                  ....*....|....*....|....*....
gi 225543361  539 VYFVTYVFFVFFVLLNMFLAIINDTYSEV 567
Cdd:pfam08016 396 LLFLTFVFLVIFILLNLFLAIINDSYVEV 424
Fer4_24 super family cl39498
Ferredoxin I 4Fe-4S cluster domain; This is domain is found in Ferredoxin I (FdI), an ...
699-732 2.18e-10

Ferredoxin I 4Fe-4S cluster domain; This is domain is found in Ferredoxin I (FdI), an Iron-sulfur ([Fe-S]) cluster-containing protein, present in species such as Azotobacter vinelandii. [Fe-S] proteins participate in electron transfer, catalytic, regulatory, and structural function. The FdI cluster exhibits a pH-dependent reduction potential and reversible protonation in the reduced state.


The actual alignment was detected with superfamily member pfam18109:

Pssm-ID: 436280 [Multi-domain]  Cd Length: 35  Bit Score: 56.22  E-value: 2.18e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 225543361  699 VSGEEFDMLTRRVLQLQCVLEGVVSQIDAVGSKL 732
Cdd:pfam18109   1 VSGEEFQTLTAQVLQLERSLAGVMSNIDAIGGKL 34
EFh super family cl08302
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
616-654 2.65e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


The actual alignment was detected with superfamily member pfam13833:

Pssm-ID: 415501 [Multi-domain]  Cd Length: 54  Bit Score: 36.52  E-value: 2.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 225543361  616 IQFEDFTSTLRELGHE---EHEITAAFTRFDQDGDHILDEEE 654
Cdd:pfam13833   5 ITREELKRALALLGLKdlsEDEVDILFREFDTDGDGYISFDE 46
 
Name Accession Description Interval E-value
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
147-567 0e+00

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 570.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  147 SFQTISSMSDFWDFAQGPLLDSLYwtkwyNNQSLGRGSHSFIYYENLLLGAPRLRQLRVRNDSCVVHEDFREDILNCYDV 226
Cdd:pfam08016   1 GLLTVTDLDDIWDWLSSVLLPALH-----SNKTPSGLPGSFIAYESLLLGVPRLRQLRVRNSSCLVPDKFVREINECHAG 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  227 YSPDKEDQ--------LPFGPQNGTAWTYHSQNELGGSSHWGRLTSYSGGGYYLDLPGSRQASAEALQGLQEGLWLDRGT 298
Cdd:pfam08016  76 YSPPSEDRkiysalpyKPVHYTSKYWWIYTPPGLLMGYDHWGYLASYPSGGYVVLLPSSREESLKRLAYLQDNNWLDRGT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  299 RVVFIDFSVYNANINLFCILRLVVEFPATGGTIPSWQIRTVKLIRYVNNWDFFIVGCEVVFCVFIFYYVVEEILEIHLHR 378
Cdd:pfam08016 156 RAVFVDFTLYNADINLFCVVTLRVEFPPTGGVLPSPSVQSVKLLRYVTNRSLFILLCEIVFVVFFLYFVVEEILKIRKHR 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  379 LRYLSSVWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPDTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYIS 458
Cdd:pfam08016 236 PSYLRSVWNLLDLAIVILSVVLIVLNIYRDFLVDRLIKSVEASPVTFIDFDRVAQLDNLYRIILAFLVFLTWLKLFKVLR 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  459 FNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVENFSTFVKCIFTQFRIILGDFDYNAIDNANRILGP 538
Cdd:pfam08016 316 FNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQAPNFSNFVKSILTLFRTILGDFGYNEIFSGNRVLGP 395
                         410       420
                  ....*....|....*....|....*....
gi 225543361  539 VYFVTYVFFVFFVLLNMFLAIINDTYSEV 567
Cdd:pfam08016 396 LLFLTFVFLVIFILLNLFLAIINDSYVEV 424
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
270-569 2.32e-26

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 116.20  E-value: 2.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  270 YYLDLPGSRQASAEALQGLQEGLWLDRG-TRVVFIDFSVYNANINLFCILRLVVEFpATGGTIP-SWQIRTVKLIRYVNN 347
Cdd:PLN03223 1092 YFFDINLSAAEAQTWLDYMIYGLMIDDVkTRKVTAQVVVYNAELGYFGNVMVFFEF-TDGGKIEvTHRLNTIRVELYETY 1170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  348 WDFFIVGCEVVFCVFIFYYVVEEILEI------HLHRLRYLSSVWNILDLV---VILLSIV---------------AVGF 403
Cdd:PLN03223 1171 EDWVRFAMEILLAIGAVYSVYEEAMDFgsskktRGSYLAYFLSGWNYVDFAsigLHLATIMmwfvfswsyarafepDIHY 1250
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  404 HIFRTLEVN------RLMGKLLQQPDTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDI 477
Cdd:PLN03223 1251 DIYKNLSASanftalRIPNELPEMNDMFLEMKNLVDYFQWYMTLSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADL 1330
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  478 LGFAIMFFIVFFAYAQLGYLLFGTQVENFSTFVKCIFTQFRIILGDFDYNAIDNAN-----RILGPVYFVTYVFFVFFVL 552
Cdd:PLN03223 1331 MHFFVIFGMVFVGYAFIGHVIFGNASVHFSDMTDSINSLFENLLGDITYFNEDLKNltglqFVVGMIYFYSYNIFVFMIL 1410
                         330
                  ....*....|....*..
gi 225543361  553 LNMFLAIINDTYSEVKE 569
Cdd:PLN03223 1411 FNFLLAIICDAFGEVKA 1427
Fer4_24 pfam18109
Ferredoxin I 4Fe-4S cluster domain; This is domain is found in Ferredoxin I (FdI), an ...
699-732 2.18e-10

Ferredoxin I 4Fe-4S cluster domain; This is domain is found in Ferredoxin I (FdI), an Iron-sulfur ([Fe-S]) cluster-containing protein, present in species such as Azotobacter vinelandii. [Fe-S] proteins participate in electron transfer, catalytic, regulatory, and structural function. The FdI cluster exhibits a pH-dependent reduction potential and reversible protonation in the reduced state.


Pssm-ID: 436280 [Multi-domain]  Cd Length: 35  Bit Score: 56.22  E-value: 2.18e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 225543361  699 VSGEEFDMLTRRVLQLQCVLEGVVSQIDAVGSKL 732
Cdd:pfam18109   1 VSGEEFQTLTAQVLQLERSLAGVMSNIDAIGGKL 34
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
362-570 4.43e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 53.55  E-value: 4.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  362 FIFYYVVEEILEIHLHRLR-YLSSVWNILDLVV-------ILLSIVAVGFHifrtlevnrlmgkllqqpdTYADFEFLAF 433
Cdd:TIGR00870 398 WVDGLRLGEEKLIWLGGIFeYIHQLWNILDFGMnsfylatFLDRPFAILFV-------------------TQAFLVLREH 458
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  434 WQTQYNNMNAVNLF-----FAWIKIFKYISFNKTMTQLSSTLAR-CAKDILGFAIMFFIVFFAYAQLGYLLF-------- 499
Cdd:TIGR00870 459 WLRFDPTLIEEALFafalvLSWLNLLYIFRGNQHLGPLQIMIGRmILGDILRFLFIYAVVLFGFACGLNQLYqyydelkl 538
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  500 -----------GTQVENFSTFVKCIFTQFRIILGDFDYNAIDNAN-RILGPVYFVTYVFFVFFVLLNMFLAIINDTYSEV 567
Cdd:TIGR00870 539 necsnpharscEKQGNAYSTLFETSQELFWAIIGLGDLLANEHKFtEFVGLLLFGAYNVIMYILLLNMLIAMMGNTYQLI 618

                  ...
gi 225543361  568 KEE 570
Cdd:TIGR00870 619 ADD 621
EF-hand_8 pfam13833
EF-hand domain pair;
616-654 2.65e-03

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 36.52  E-value: 2.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 225543361  616 IQFEDFTSTLRELGHE---EHEITAAFTRFDQDGDHILDEEE 654
Cdd:pfam13833   5 ITREELKRALALLGLKdlsEDEVDILFREFDTDGDGYISFDE 46
 
Name Accession Description Interval E-value
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
147-567 0e+00

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 570.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  147 SFQTISSMSDFWDFAQGPLLDSLYwtkwyNNQSLGRGSHSFIYYENLLLGAPRLRQLRVRNDSCVVHEDFREDILNCYDV 226
Cdd:pfam08016   1 GLLTVTDLDDIWDWLSSVLLPALH-----SNKTPSGLPGSFIAYESLLLGVPRLRQLRVRNSSCLVPDKFVREINECHAG 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  227 YSPDKEDQ--------LPFGPQNGTAWTYHSQNELGGSSHWGRLTSYSGGGYYLDLPGSRQASAEALQGLQEGLWLDRGT 298
Cdd:pfam08016  76 YSPPSEDRkiysalpyKPVHYTSKYWWIYTPPGLLMGYDHWGYLASYPSGGYVVLLPSSREESLKRLAYLQDNNWLDRGT 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  299 RVVFIDFSVYNANINLFCILRLVVEFPATGGTIPSWQIRTVKLIRYVNNWDFFIVGCEVVFCVFIFYYVVEEILEIHLHR 378
Cdd:pfam08016 156 RAVFVDFTLYNADINLFCVVTLRVEFPPTGGVLPSPSVQSVKLLRYVTNRSLFILLCEIVFVVFFLYFVVEEILKIRKHR 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  379 LRYLSSVWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPDTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYIS 458
Cdd:pfam08016 236 PSYLRSVWNLLDLAIVILSVVLIVLNIYRDFLVDRLIKSVEASPVTFIDFDRVAQLDNLYRIILAFLVFLTWLKLFKVLR 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  459 FNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVENFSTFVKCIFTQFRIILGDFDYNAIDNANRILGP 538
Cdd:pfam08016 316 FNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGTQAPNFSNFVKSILTLFRTILGDFGYNEIFSGNRVLGP 395
                         410       420
                  ....*....|....*....|....*....
gi 225543361  539 VYFVTYVFFVFFVLLNMFLAIINDTYSEV 567
Cdd:pfam08016 396 LLFLTFVFLVIFILLNLFLAIINDSYVEV 424
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
270-569 2.32e-26

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 116.20  E-value: 2.32e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  270 YYLDLPGSRQASAEALQGLQEGLWLDRG-TRVVFIDFSVYNANINLFCILRLVVEFpATGGTIP-SWQIRTVKLIRYVNN 347
Cdd:PLN03223 1092 YFFDINLSAAEAQTWLDYMIYGLMIDDVkTRKVTAQVVVYNAELGYFGNVMVFFEF-TDGGKIEvTHRLNTIRVELYETY 1170
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  348 WDFFIVGCEVVFCVFIFYYVVEEILEI------HLHRLRYLSSVWNILDLV---VILLSIV---------------AVGF 403
Cdd:PLN03223 1171 EDWVRFAMEILLAIGAVYSVYEEAMDFgsskktRGSYLAYFLSGWNYVDFAsigLHLATIMmwfvfswsyarafepDIHY 1250
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  404 HIFRTLEVN------RLMGKLLQQPDTYADFEFLAFWQTQYNNMNAVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDI 477
Cdd:PLN03223 1251 DIYKNLSASanftalRIPNELPEMNDMFLEMKNLVDYFQWYMTLSGINIILLLGRILKLMDFQPRLGVITRTLWLAGADL 1330
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  478 LGFAIMFFIVFFAYAQLGYLLFGTQVENFSTFVKCIFTQFRIILGDFDYNAIDNAN-----RILGPVYFVTYVFFVFFVL 552
Cdd:PLN03223 1331 MHFFVIFGMVFVGYAFIGHVIFGNASVHFSDMTDSINSLFENLLGDITYFNEDLKNltglqFVVGMIYFYSYNIFVFMIL 1410
                         330
                  ....*....|....*..
gi 225543361  553 LNMFLAIINDTYSEVKE 569
Cdd:PLN03223 1411 FNFLLAIICDAFGEVKA 1427
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
356-570 4.28e-20

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 90.02  E-value: 4.28e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  356 EVVFCVFIFYYVVEEILEIHL--HRLRYLSSVWNILDLVVILLSIVAVGFHIFRTLEVNRlmgkllqqpdtyadfeflaf 433
Cdd:pfam00520  36 EILDYVFTGIFTLEMLLKIIAagFKKRYFRSPWNILDFVVVLPSLISLVLSSVGSLSGLR-------------------- 95
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  434 wqtqynnmnaVNLFFAWIKIFKYISFNKTMTQLSSTLARCAKDILGFAIMFFIVFFAYAQLGYLLFGTQVE--------- 504
Cdd:pfam00520  96 ----------VLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKtwenpdngr 165
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 225543361  505 -NFSTFVKCIFTQFRII----LGDFDYNAIDNANRILGPVYFVTYVFFVFFVLLNMFLAIINDTYSEVKEE 570
Cdd:pfam00520 166 tNFDNFPNAFLWLFQTMttegWGDIMYDTIDGKGEFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTER 236
Fer4_24 pfam18109
Ferredoxin I 4Fe-4S cluster domain; This is domain is found in Ferredoxin I (FdI), an ...
699-732 2.18e-10

Ferredoxin I 4Fe-4S cluster domain; This is domain is found in Ferredoxin I (FdI), an Iron-sulfur ([Fe-S]) cluster-containing protein, present in species such as Azotobacter vinelandii. [Fe-S] proteins participate in electron transfer, catalytic, regulatory, and structural function. The FdI cluster exhibits a pH-dependent reduction potential and reversible protonation in the reduced state.


Pssm-ID: 436280 [Multi-domain]  Cd Length: 35  Bit Score: 56.22  E-value: 2.18e-10
                          10        20        30
                  ....*....|....*....|....*....|....
gi 225543361  699 VSGEEFDMLTRRVLQLQCVLEGVVSQIDAVGSKL 732
Cdd:pfam18109   1 VSGEEFQTLTAQVLQLERSLAGVMSNIDAIGGKL 34
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
362-570 4.43e-07

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 53.55  E-value: 4.43e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  362 FIFYYVVEEILEIHLHRLR-YLSSVWNILDLVV-------ILLSIVAVGFHifrtlevnrlmgkllqqpdTYADFEFLAF 433
Cdd:TIGR00870 398 WVDGLRLGEEKLIWLGGIFeYIHQLWNILDFGMnsfylatFLDRPFAILFV-------------------TQAFLVLREH 458
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  434 WQTQYNNMNAVNLF-----FAWIKIFKYISFNKTMTQLSSTLAR-CAKDILGFAIMFFIVFFAYAQLGYLLF-------- 499
Cdd:TIGR00870 459 WLRFDPTLIEEALFafalvLSWLNLLYIFRGNQHLGPLQIMIGRmILGDILRFLFIYAVVLFGFACGLNQLYqyydelkl 538
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 225543361  500 -----------GTQVENFSTFVKCIFTQFRIILGDFDYNAIDNAN-RILGPVYFVTYVFFVFFVLLNMFLAIINDTYSEV 567
Cdd:TIGR00870 539 necsnpharscEKQGNAYSTLFETSQELFWAIIGLGDLLANEHKFtEFVGLLLFGAYNVIMYILLLNMLIAMMGNTYQLI 618

                  ...
gi 225543361  568 KEE 570
Cdd:TIGR00870 619 ADD 621
EF-hand_8 pfam13833
EF-hand domain pair;
616-654 2.65e-03

EF-hand domain pair;


Pssm-ID: 404678 [Multi-domain]  Cd Length: 54  Bit Score: 36.52  E-value: 2.65e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 225543361  616 IQFEDFTSTLRELGHE---EHEITAAFTRFDQDGDHILDEEE 654
Cdd:pfam13833   5 ITREELKRALALLGLKdlsEDEVDILFREFDTDGDGYISFDE 46
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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