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Conserved domains on  [gi|33438821|ref|NP_878103|]
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Mco6p [Saccharomyces cerevisiae S288C]

Protein Classification

DUF5310 domain-containing protein( domain architecture ID 13879186)

DUF5310 domain-containing protein similar to Saccharomyces cerevisiae UPF0618 protein YJL127C-B

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Emr1 pfam17237
ERMES regulator 1; The endoplasmic reticulum-mitochondria encounter structure (ERMES) complex ...
 5-48 3.54e-15

ERMES regulator 1; The endoplasmic reticulum-mitochondria encounter structure (ERMES) complex creates contact sites between the endoplasmic reticulum and mitochondria, playing crucial roles in interorganelle communication, mitochondrial fission, mtDNA inheritance, lipid transfer, and autophagy. Emr1, also known as Mco6 in budding yeasts, mediates the formation ERMES foci, thereby contributing to the formation of ER-mitochondrial contact sites.


:

Pssm-ID: 435804  Cd Length: 44  Bit Score: 61.47  E-value: 3.54e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 33438821    5 FNQIRSIFTALHTPTQQIQLSRRAFFQFLGYLGSCVVISLAAQS 48
Cdd:pfam17237  1 LPNLRRIFAESRTEEEERSLSRKAFFQLLGFLGSCVVISLVAQR 44
 
Name Accession Description Interval E-value
Emr1 pfam17237
ERMES regulator 1; The endoplasmic reticulum-mitochondria encounter structure (ERMES) complex ...
 5-48 3.54e-15

ERMES regulator 1; The endoplasmic reticulum-mitochondria encounter structure (ERMES) complex creates contact sites between the endoplasmic reticulum and mitochondria, playing crucial roles in interorganelle communication, mitochondrial fission, mtDNA inheritance, lipid transfer, and autophagy. Emr1, also known as Mco6 in budding yeasts, mediates the formation ERMES foci, thereby contributing to the formation of ER-mitochondrial contact sites.


Pssm-ID: 435804  Cd Length: 44  Bit Score: 61.47  E-value: 3.54e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 33438821    5 FNQIRSIFTALHTPTQQIQLSRRAFFQFLGYLGSCVVISLAAQS 48
Cdd:pfam17237  1 LPNLRRIFAESRTEEEERSLSRKAFFQLLGFLGSCVVISLVAQR 44
 
Name Accession Description Interval E-value
Emr1 pfam17237
ERMES regulator 1; The endoplasmic reticulum-mitochondria encounter structure (ERMES) complex ...
 5-48 3.54e-15

ERMES regulator 1; The endoplasmic reticulum-mitochondria encounter structure (ERMES) complex creates contact sites between the endoplasmic reticulum and mitochondria, playing crucial roles in interorganelle communication, mitochondrial fission, mtDNA inheritance, lipid transfer, and autophagy. Emr1, also known as Mco6 in budding yeasts, mediates the formation ERMES foci, thereby contributing to the formation of ER-mitochondrial contact sites.


Pssm-ID: 435804  Cd Length: 44  Bit Score: 61.47  E-value: 3.54e-15
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 33438821    5 FNQIRSIFTALHTPTQQIQLSRRAFFQFLGYLGSCVVISLAAQS 48
Cdd:pfam17237  1 LPNLRRIFAESRTEEEERSLSRKAFFQLLGFLGSCVVISLVAQR 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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