NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|33469051|ref|NP_878259|]
View 

tubulin polymerization-promoting protein [Mus musculus]

Protein Classification

tubulin polymerization-promoting family protein( domain architecture ID 10527554)

tubulin polymerization-promoting family protein similar to human tubulin polymerization-promoting protein (TPPP), a regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
p25-alpha pfam05517
p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. ...
 51-206 4.69e-84

p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.


:

Pssm-ID: 461670  Cd Length: 155  Bit Score: 246.41  E-value: 4.69e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469051    51 EEAFRRFAVHGDTRATGKEMHGKNWSKLCKDCHVIDgKNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDK 130
Cdd:pfam05517   1 EEAFKAFAKFGDTKATGKEMDGKNFSKLCKDCGVID-KKVTSTDVDIIFSKVKAKSARTITFEQFKEALEELAEKRFKKK 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33469051   131 SSEEAVREVHRLIEGRAPVISGVTKAVSSPTVSRLTDTSKFTGSHKERFDQSGKGKGKAGRVDLVDESGYVPGYKH 206
Cdd:pfam05517  80 VKEEELELIEKLIEGKGPATTGVTKATKAGAVDRLTDTSKYTGSHKERFDESGKGKGIAGREDRVDNSGYVRGYKG 155
 
Name Accession Description Interval E-value
p25-alpha pfam05517
p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. ...
 51-206 4.69e-84

p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.


Pssm-ID: 461670  Cd Length: 155  Bit Score: 246.41  E-value: 4.69e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469051    51 EEAFRRFAVHGDTRATGKEMHGKNWSKLCKDCHVIDgKNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDK 130
Cdd:pfam05517   1 EEAFKAFAKFGDTKATGKEMDGKNFSKLCKDCGVID-KKVTSTDVDIIFSKVKAKSARTITFEQFKEALEELAEKRFKKK 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33469051   131 SSEEAVREVHRLIEGRAPVISGVTKAVSSPTVSRLTDTSKFTGSHKERFDQSGKGKGKAGRVDLVDESGYVPGYKH 206
Cdd:pfam05517  80 VKEEELELIEKLIEGKGPATTGVTKATKAGAVDRLTDTSKYTGSHKERFDESGKGKGIAGREDRVDNSGYVRGYKG 155
 
Name Accession Description Interval E-value
p25-alpha pfam05517
p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. ...
 51-206 4.69e-84

p25-alpha; This family encodes a 25 kDa protein that is phosphorylated by a Ser/Thr-Pro kinase. It has been described as a brain specific protein, but it is found in Tetrahymena thermophila.


Pssm-ID: 461670  Cd Length: 155  Bit Score: 246.41  E-value: 4.69e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33469051    51 EEAFRRFAVHGDTRATGKEMHGKNWSKLCKDCHVIDgKNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDK 130
Cdd:pfam05517   1 EEAFKAFAKFGDTKATGKEMDGKNFSKLCKDCGVID-KKVTSTDVDIIFSKVKAKSARTITFEQFKEALEELAEKRFKKK 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 33469051   131 SSEEAVREVHRLIEGRAPVISGVTKAVSSPTVSRLTDTSKFTGSHKERFDQSGKGKGKAGRVDLVDESGYVPGYKH 206
Cdd:pfam05517  80 VKEEELELIEKLIEGKGPATTGVTKATKAGAVDRLTDTSKYTGSHKERFDESGKGKGIAGREDRVDNSGYVRGYKG 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH