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Conserved domains on  [gi|56549145|ref|NP_878919|]
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metalloreductase STEAP3 isoform a [Homo sapiens]

Protein Classification

COG2085 and Ferric_reduct domain-containing protein( domain architecture ID 11946522)

COG2085 and Ferric_reduct domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
41-232 6.50e-50

Predicted dinucleotide-binding enzyme [General function prediction only];


:

Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 169.58  E-value: 6.50e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145  41 VGILGSGDFARSLATRLVGSGFKVVVGSRNPKR----TARLFPSAAQVTFqEEAVSSPEVIFVAVFREHYSSLC-SLSDQ 115
Cdd:COG2085   1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKaaalAAELGPGARAGTN-AEAAAAADVVVLAVPYEAVPDVLeSLGDA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145 116 LAGKILVDVSNPTEQE-----HLQHRESNAEYLASLFPTCTVVKAFNVISAWTLQAGPR--DGNRQVPICGDQPEAKRAV 188
Cdd:COG2085  80 LAGKIVIDATNPLPERdgfilDPPGGGSAAELVAALLPGARVVKAFNTIGAAVLADPARpaGGRRDVFVAGDDAEAKAVV 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 56549145 189 SEMALAMGFMPVDMGSLASAWEVEAM-PLRLLPAWKVPTLLALGL 232
Cdd:COG2085 160 AALIEDLGFDPVDAGPLANARRLEPLtPLLINLARTAGLELGFRL 204
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 272-415 1.78e-07

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


:

Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 49.96  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145   272 VAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWldhwlqhRKQIGLLSFFCAALHALYSFCLPLRRahrydlvnlavkqv 351
Cdd:pfam01794   4 LALALLPLLLLLALRNNPLEWLTGLSYDRLLLF-------HRWLGRLAFLLALLHVILYLIYWLRF-------------- 62

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56549145   352 lanksHLWVEEEVWRMEIYLSLGVLALGTLSLLAVTSLPSIANsLNWREFSFVQSSLGFVALVL 415
Cdd:pfam01794  63 -----SLEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFRR-LSYELFLYLHILLAVAFLLL 120
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
41-232 6.50e-50

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 169.58  E-value: 6.50e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145  41 VGILGSGDFARSLATRLVGSGFKVVVGSRNPKR----TARLFPSAAQVTFqEEAVSSPEVIFVAVFREHYSSLC-SLSDQ 115
Cdd:COG2085   1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKaaalAAELGPGARAGTN-AEAAAAADVVVLAVPYEAVPDVLeSLGDA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145 116 LAGKILVDVSNPTEQE-----HLQHRESNAEYLASLFPTCTVVKAFNVISAWTLQAGPR--DGNRQVPICGDQPEAKRAV 188
Cdd:COG2085  80 LAGKIVIDATNPLPERdgfilDPPGGGSAAELVAALLPGARVVKAFNTIGAAVLADPARpaGGRRDVFVAGDDAEAKAVV 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 56549145 189 SEMALAMGFMPVDMGSLASAWEVEAM-PLRLLPAWKVPTLLALGL 232
Cdd:COG2085 160 AALIEDLGFDPVDAGPLANARRLEPLtPLLINLARTAGLELGFRL 204
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
42-127 2.05e-21

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 88.44  E-value: 2.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145    42 GILGSGDFARSLATRLVGSGFK--VVVGSRNPKRTARLFPSA---AQVTFQEEAVSSPEVIFVAVFREHYSSLCS-LSDQ 115
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGPHevVVANSRNPEKAEELAEEYgvgATAVDNEEAAEEADVVFLAVKPEDAPDVLSeLSDL 80

                          90
                  ....*....|..
gi 56549145   116 LAGKILVDVSNP 127
Cdd:pfam03807  81 LKGKIVISIAAG 92
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 272-415 1.78e-07

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 49.96  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145   272 VAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWldhwlqhRKQIGLLSFFCAALHALYSFCLPLRRahrydlvnlavkqv 351
Cdd:pfam01794   4 LALALLPLLLLLALRNNPLEWLTGLSYDRLLLF-------HRWLGRLAFLLALLHVILYLIYWLRF-------------- 62

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56549145   352 lanksHLWVEEEVWRMEIYLSLGVLALGTLSLLAVTSLPSIANsLNWREFSFVQSSLGFVALVL 415
Cdd:pfam01794  63 -----SLEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFRR-LSYELFLYLHILLAVAFLLL 120
 
Name Accession Description Interval E-value
COG2085 COG2085
Predicted dinucleotide-binding enzyme [General function prediction only];
41-232 6.50e-50

Predicted dinucleotide-binding enzyme [General function prediction only];


Pssm-ID: 441688 [Multi-domain]  Cd Length: 205  Bit Score: 169.58  E-value: 6.50e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145  41 VGILGSGDFARSLATRLVGSGFKVVVGSRNPKR----TARLFPSAAQVTFqEEAVSSPEVIFVAVFREHYSSLC-SLSDQ 115
Cdd:COG2085   1 IGIIGTGNIGSALARRLAAAGHEVVIGSRDPEKaaalAAELGPGARAGTN-AEAAAAADVVVLAVPYEAVPDVLeSLGDA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145 116 LAGKILVDVSNPTEQE-----HLQHRESNAEYLASLFPTCTVVKAFNVISAWTLQAGPR--DGNRQVPICGDQPEAKRAV 188
Cdd:COG2085  80 LAGKIVIDATNPLPERdgfilDPPGGGSAAELVAALLPGARVVKAFNTIGAAVLADPARpaGGRRDVFVAGDDAEAKAVV 159

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 56549145 189 SEMALAMGFMPVDMGSLASAWEVEAM-PLRLLPAWKVPTLLALGL 232
Cdd:COG2085 160 AALIEDLGFDPVDAGPLANARRLEPLtPLLINLARTAGLELGFRL 204
F420_oxidored pfam03807
NADP oxidoreductase coenzyme F420-dependent;
42-127 2.05e-21

NADP oxidoreductase coenzyme F420-dependent;


Pssm-ID: 397743 [Multi-domain]  Cd Length: 92  Bit Score: 88.44  E-value: 2.05e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145    42 GILGSGDFARSLATRLVGSGFK--VVVGSRNPKRTARLFPSA---AQVTFQEEAVSSPEVIFVAVFREHYSSLCS-LSDQ 115
Cdd:pfam03807   1 GFIGAGNMGEALARGLVAAGPHevVVANSRNPEKAEELAEEYgvgATAVDNEEAAEEADVVFLAVKPEDAPDVLSeLSDL 80

                          90
                  ....*....|..
gi 56549145   116 LAGKILVDVSNP 127
Cdd:pfam03807  81 LKGKIVISIAAG 92
Ferric_reduct pfam01794
Ferric reductase like transmembrane component; This family includes a common region in the ...
 272-415 1.78e-07

Ferric reductase like transmembrane component; This family includes a common region in the transmembrane proteins mammalian cytochrome B-245 heavy chain (gp91-phox), ferric reductase transmembrane component in yeast and respiratory burst oxidase from mouse-ear cress. This may be a family of flavocytochromes capable of moving electrons across the plasma membrane. The Frp1 protein from S. pombe is a ferric reductase component and is required for cell surface ferric reductase activity, mutants in frp1 are deficient in ferric iron uptake. Cytochrome B-245 heavy chain is a FAD-dependent dehydrogenase it is also has electron transferase activity which reduces molecular oxygen to superoxide anion, a precursor in the production of microbicidal oxidants. Mutations in the sequence of cytochrome B-245 heavy chain (gp91-phox) lead to the X-linked chronic granulomatous disease. The bacteriocidal ability of phagocytic cells is reduced and is characterized by the absence of a functional plasma membrane associated NADPH oxidase. The chronic granulomatous disease gene codes for the beta chain of cytochrome B-245 and cytochrome B-245 is missing from patients with the disease.


Pssm-ID: 426438 [Multi-domain]  Cd Length: 121  Bit Score: 49.96  E-value: 1.78e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145   272 VAYVLLSLVYLPGVLAAALQLRRGTKYQRFPDWldhwlqhRKQIGLLSFFCAALHALYSFCLPLRRahrydlvnlavkqv 351
Cdd:pfam01794   4 LALALLPLLLLLALRNNPLEWLTGLSYDRLLLF-------HRWLGRLAFLLALLHVILYLIYWLRF-------------- 62

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 56549145   352 lanksHLWVEEEVWRMEIYLSLGVLALGTLSLLAVTSLPSIANsLNWREFSFVQSSLGFVALVL 415
Cdd:pfam01794  63 -----SLEGILDLLLKRPYNILGIIALVLLVLLAITSLPPFRR-LSYELFLYLHILLAVAFLLL 120
COG5495 COG5495
Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains ...
 39-196 6.62e-04

Predicted oxidoreductase, contains short-chain dehydrogenase (SDR) and DUF2520 domains [General function prediction only];


Pssm-ID: 444246 [Multi-domain]  Cd Length: 286  Bit Score: 41.72  E-value: 6.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145  39 PKVGILGSGDFARSLATRLVGSGFKVV-VGSRNP---KRTARLFPSAAQVTFqEEAVSSPEVIFVAVfreHYSSLCSLSD 114
Cdd:COG5495   4 MKIGIIGAGRVGTALAAALRAAGHEVVgVYSRSPasaERAAALLGAVPALDL-EELAAEADLVLLAV---PDDAIAEVAA 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145 115 QLA-------GKILVDVSNPTEQEHLQHRESNAEYLASLFPTCTVVKAFNVISAWtlqagprdgnRQVPIC--GDqPEAK 185
Cdd:COG5495  80 GLAaagalrpGQLVVHTSGALGSDVLAPAARAGALTGSFHPLQTFSGPREDLERL----------AGIPFAieGD-EEAL 148

                       170
                ....*....|.
gi 56549145 186 RAVSEMALAMG 196
Cdd:COG5495 149 PVLEALAEALG 159
ProC COG0345
Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; ...
 39-101 1.44e-03

Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Pyrroline-5-carboxylate reductase is part of the Pathway/BioSystem: Proline biosynthesis


Pssm-ID: 440114 [Multi-domain]  Cd Length: 267  Bit Score: 40.43  E-value: 1.44e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 56549145  39 PKVGILGSGDFARSLATRLVGSGFK---VVVGSRNPKRTARLfpsAAQVTFQ-----EEAVSSPEVIFVAV 101
Cdd:COG0345   3 MKIGFIGAGNMGSAIIKGLLKSGVPpedIIVSDRSPERLEAL---AERYGVRvttdnAEAAAQADVVVLAV 70
NAD_binding_2 pfam03446
NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of ...
 40-126 1.99e-03

NAD binding domain of 6-phosphogluconate dehydrogenase; The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.


Pssm-ID: 427298 [Multi-domain]  Cd Length: 159  Bit Score: 38.99  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 56549145    40 KVGILGSGDFARSLATRLVGSGFKVVVGSRNPKRTARLFPSAAQVTFQ-EEAVSSPEVIFVAV----------FREHYSS 108
Cdd:pfam03446   1 KIGFIGLGVMGSPMALNLLKAGYTVTVYNRTPEKVEELVAAGAIAAASpAEFVAGLDVVITMVpagaavdaviFGEGLLP 80

                          90
                  ....*....|....*...
gi 56549145   109 LCSlsdqlAGKILVDVSN 126
Cdd:pfam03446  81 GLK-----PGDIIIDGST 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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