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Conserved domains on  [gi|33946304|ref|NP_891977|]
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sodium/calcium exchanger 3 isoform D precursor [Homo sapiens]

Protein Classification

CaCA family sodium/calcium exchanger( domain architecture ID 11489785)

CaCA family sodium/calcium exchanger mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-921 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1689.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304     1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAggSGDVPSTGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVY 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARA--LTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304    81 FVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF 160
Cdd:TIGR00845  79 FVAMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   161 IAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Cdd:TIGR00845 159 EAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPK---GIEMDGKMMNSH---FLDGNLVpLEGKEVDESRR 314
Cdd:TIGR00845 239 FPLCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKsktEIEMDGKMVNSHvdnFLDGALV-LEVKEFDEARR 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   315 EMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-D 393
Cdd:TIGR00845 318 EMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEnD 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   394 FISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Cdd:TIGR00845 398 PVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDI 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   474 FEEDEHFFVRLSNVRIEEEQpeeGMPPAIFNSLplpRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVL 553
Cdd:TIGR00845 478 FEEDEHFYVRLSNLRVGSED---GILEANHVSA---VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVL 551

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   554 RTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISDV-- 631
Cdd:TIGR00845 552 RTSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAAll 631

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   632 -------TDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSA 704
Cdd:TIGR00845 632 lnetitdDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSA 711

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   705 AGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVT 784
Cdd:TIGR00845 712 GDDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVT 791

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   785 AVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTI 864
Cdd:TIGR00845 792 AVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTI 871

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 33946304   865 FAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 921
Cdd:TIGR00845 872 FAFICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-921 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1689.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304     1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAggSGDVPSTGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVY 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARA--LTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304    81 FVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF 160
Cdd:TIGR00845  79 FVAMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   161 IAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Cdd:TIGR00845 159 EAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPK---GIEMDGKMMNSH---FLDGNLVpLEGKEVDESRR 314
Cdd:TIGR00845 239 FPLCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKsktEIEMDGKMVNSHvdnFLDGALV-LEVKEFDEARR 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   315 EMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-D 393
Cdd:TIGR00845 318 EMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEnD 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   394 FISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Cdd:TIGR00845 398 PVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDI 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   474 FEEDEHFFVRLSNVRIEEEQpeeGMPPAIFNSLplpRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVL 553
Cdd:TIGR00845 478 FEEDEHFYVRLSNLRVGSED---GILEANHVSA---VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVL 551

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   554 RTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISDV-- 631
Cdd:TIGR00845 552 RTSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAAll 631

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   632 -------TDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSA 704
Cdd:TIGR00845 632 lnetitdDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSA 711

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   705 AGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVT 784
Cdd:TIGR00845 712 GDDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVT 791

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   785 AVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTI 864
Cdd:TIGR00845 792 AVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTI 871

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 33946304   865 FAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 921
Cdd:TIGR00845 872 FAFICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 253-380 7.41e-83

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 262.63  E-value: 7.41e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   253 KRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG----IEMDGKMMNSHF----LDGNLVPLEGKEVDESRREMIRILKDLK 324
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELGPKegieMLMDGKLVGSHVmeggAEGPVDDPEAKELDEARREVIRILKELK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 33946304   325 QKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKA 380
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 396-485 2.59e-32

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 120.44  E-value: 2.59e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304    396 SKVFFDPCSYQCLENCGAVLLTVVRKGGDmSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFE 475
Cdd:smart00237   2 GSVGFEQPVYTVSESDGEVEVCVVRTGGA-RGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYE 80

                           90
                   ....*....|
gi 33946304    476 EDEHFFVRLS 485
Cdd:smart00237  81 KDETFYVRLS 90
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
753-909 2.64e-12

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 68.62  E-value: 2.64e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304 753 AVSILIIGMLTAIIG-----DLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYaDASIGNVTGSNAVNVF 827
Cdd:COG0530 153 ALLLLVLGLALLVVGarllvDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGED-DLAVGNIIGSNIFNIL 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304 828 LGIGLAWSVAAIywalqgqefHVSAGTLAFSVTLFTIFAFVCISVLLYRRRphlggeLGGPRGcklattWLFVSLWLLYI 907
Cdd:COG0530 232 LVLGIGALITPI---------PVDPAVLSFDLPVMLAATLLLLGLLRTGGR------IGRWEG------LLLLALYLAYL 290


                ..
gi 33946304 908 LF 909
Cdd:COG0530 291 AL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 752-833 3.24e-05

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 46.95  E-value: 3.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304  752 FAVSILIIGMLTAIIGD-----LASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDvYADASIGNVTGSNAVNV 826
Cdd:PRK10734   3 LATALLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHG-QRDLAVGTALGSNITNI 81


                 ....*..
gi 33946304  827 FLGIGLA 833
Cdd:PRK10734  82 LLILGLA 88
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 1-921 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1689.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304     1 MAWLRLQPLTSAFLHFGLVTFVLFLNGLRAEAggSGDVPSTGQNNESCSGSSDCKEGVILPIWYPENPSLGDKIARVIVY 80
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARA--LTEASSSGSNTGECTGSYYCKEGVILPIWEPQNPSVGDKIARATVY 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304    81 FVALIYMFLGVSIIADRFMASIEVITSQEREVTIKKPNGETSTTTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGHGF 160
Cdd:TIGR00845  79 FVAMVYMFLGVSIIADRFMASIEVITSQEKEITIKKPNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   161 IAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKHLRVFFITAAWSIFAYIWLYMILAVFSPGVVQVWEGLLTLFF 240
Cdd:TIGR00845 159 EAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRKIKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFF 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   241 FPVCVLLAWVADKRLLFYKYMHKKYRTDKHRGIIIETEGDHPK---GIEMDGKMMNSH---FLDGNLVpLEGKEVDESRR 314
Cdd:TIGR00845 239 FPLCVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIETEGDRPKsktEIEMDGKMVNSHvdnFLDGALV-LEVKEFDEARR 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   315 EMIRILKDLKQKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKASSMSEVHTDEPE-D 393
Cdd:TIGR00845 318 EMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSRAFYRIQATRLMTGAGNILKKHAADAARKAVSMHEVATDDEEnD 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   394 FISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDI 473
Cdd:TIGR00845 398 PVSKIFFEPGHYTCLENCGTVALTVVRRGGDLTNTVYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDI 477

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   474 FEEDEHFFVRLSNVRIEEEQpeeGMPPAIFNSLplpRAVLASPCVATVTILDDDHAGIFTFECDTIHVSESIGVMEVKVL 553
Cdd:TIGR00845 478 FEEDEHFYVRLSNLRVGSED---GILEANHVSA---VAQLASPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVL 551

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   554 RTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEPKWMERGISDV-- 631
Cdd:TIGR00845 552 RTSGARGTVIVPYRTVEGTARGGGKDFEDTCGELEFENDETEKTIRVKIVDDEEYEKNDTFFIELGEPRWAKRGIKAAll 631

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   632 -------TDRKLTMEEEEAKRIAEMGKPVLGEHPKLEVIIEESYEFKTTVDKLIKKTNLALVVGTHSWRDQFMEAITVSA 704
Cdd:TIGR00845 632 lnetitdDDQKLTSKEEEERRIAEMGKPRLGEHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSA 711

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   705 AGDEDEDESGEERLPSCFDYVMHFLTVFWKVLFACVPPTEYCHGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVT 784
Cdd:TIGR00845 712 GDDDDDDEDGEEKLPSCFDYVMHFLTVFWKVLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVT 791

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   785 AVVFVAFGTSVPDTFASKAAALQDVYADASIGNVTGSNAVNVFLGIGLAWSVAAIYWALQGQEFHVSAGTLAFSVTLFTI 864
Cdd:TIGR00845 792 AVVFVALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTI 871

                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 33946304   865 FAFVCISVLLYRRRPHLGGELGGPRGCKLATTWLFVSLWLLYILFATLEAYCYIKGF 921
Cdd:TIGR00845 872 FAFICIGVLLYRRRPEIGGELGGPRTAKLLTSALFVLLWLLYILFSSLEAYCHIKGF 928
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 253-380 7.41e-83

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 262.63  E-value: 7.41e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   253 KRLLFYKYMHKKYRTDKHRGIIIETEGDHPKG----IEMDGKMMNSHF----LDGNLVPLEGKEVDESRREMIRILKDLK 324
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKRRGIIVETEGELGPKegieMLMDGKLVGSHVmeggAEGPVDDPEAKELDEARREVIRILKELK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 33946304   325 QKHPEKDLDQLVEMANYYALSHQQKSRAFYRIQATRMMTGAGNILKKHAAEQAKKA 380
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAADQARKA 136
Calx-beta pfam03160
Calx-beta domain;
395-485 8.62e-40

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 141.62  E-value: 8.62e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   395 ISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIF 474
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                          90
                  ....*....|.
gi 33946304   475 EEDEHFFVRLS 485
Cdd:pfam03160  81 EGDENFFVLLS 91
Calx-beta pfam03160
Calx-beta domain;
529-619 5.61e-34

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 125.05  E-value: 5.61e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   529 AGIFTFECDTIHVSESIGVMEVKVLRTSGA-RGTVIVPFRTVEGTAKGGgEDFEDTYGELEFKNDETVKTIRVKIVDEEE 607
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAG-DDYEPVEGELVFGPGETEKCINVTIIDDDV 79

                          90
                  ....*....|..
gi 33946304   608 YERQENFFIALG 619
Cdd:pfam03160  80 YEGDENFFVLLS 91
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 396-485 2.59e-32

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 120.44  E-value: 2.59e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304    396 SKVFFDPCSYQCLENCGAVLLTVVRKGGDmSKTMYVDYKTEDGSANAGADYEFTEGTVVLKPGETQKEFSVGIIDDDIFE 475
Cdd:smart00237   2 GSVGFEQPVYTVSESDGEVEVCVVRTGGA-RGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYE 80

                           90
                   ....*....|
gi 33946304    476 EDEHFFVRLS 485
Cdd:smart00237  81 KDETFYVRLS 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 529-619 1.34e-30

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 115.43  E-value: 1.34e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304    529 AGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKgGGEDFEDTYGELEFKNDETVKTIRVKIVDEEEY 608
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTAT-AGSDYEPVPGELTFPPGETEKEIRIKIIDDDIY 79

                           90
                   ....*....|.
gi 33946304    609 ERQENFFIALG 619
Cdd:smart00237  80 EKDETFYVRLS 90
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 747-912 5.61e-24

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 98.83  E-value: 5.61e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   747 HGWACFAVSILIIGMLTAIIGDLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDvYADASIGNVTGSNAVNV 826
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRG-EPDLALGNVIGSNIFNI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   827 FLGIGLAWSVAAIYWALQGQEFHvsagtlaFSVTLFTIFAFVCISVLLYRRRphlggelggPRGCKLATTWLFVSLWLLY 906
Cdd:pfam01699  80 LLVLGLSALIGPVKVDSLLLKLD-------LGVLLLVALLLLLLLLLLLLPL---------FGRLSRFEGLVLLLLYIVY 143


                  ....*.
gi 33946304   907 ILFATL 912
Cdd:pfam01699 144 LVFQIV 149
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 79-250 1.92e-19

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 85.73  E-value: 1.92e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304    79 VYFVALIYMFLGVSIIADRFMASIEVITsqerevtikkpngetsttTIRVWNETVSNLTLMALGSSAPEILLSLIEVCGH 158
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLA------------------RVLGISGTVLGLTILALGTSLPELVSSIIAALRG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   159 GfiaGDLGPSTIVGSAAFNMFIIIGICVYV--IPDGETRKIKHLRVFFITAAWSIFAYIWLYMILavfsPGVVQVWEGLL 236
Cdd:pfam01699  63 E---PDLALGNVIGSNIFNILLVLGLSALIgpVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLV 135

                         170
                  ....*....|....
gi 33946304   237 TLFFFPVCVLLAWV 250
Cdd:pfam01699 136 LLLLYIVYLVFQIV 149
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
753-909 2.64e-12

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 68.62  E-value: 2.64e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304 753 AVSILIIGMLTAIIG-----DLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVYaDASIGNVTGSNAVNVF 827
Cdd:COG0530 153 ALLLLVLGLALLVVGarllvDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAARKGED-DLAVGNIIGSNIFNIL 231

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304 828 LGIGLAWSVAAIywalqgqefHVSAGTLAFSVTLFTIFAFVCISVLLYRRRphlggeLGGPRGcklattWLFVSLWLLYI 907
Cdd:COG0530 232 LVLGIGALITPI---------PVDPAVLSFDLPVMLAATLLLLGLLRTGGR------IGRWEG------LLLLALYLAYL 290


                ..
gi 33946304 908 LF 909
Cdd:COG0530 291 AL 292
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 77-249 1.52e-11

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 68.48  E-value: 1.52e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304     77 VIVYFVALIYMFLGVSIIADR-FMASIEVITSQERevtikkpngetstttirvWNETVSNLTLMALGSSAPEILLSLIEV 155
Cdd:TIGR00927  457 VVLHIFGMMYVFVALAIVCDEyFVPALGVITDKLQ------------------ISEDVAGATFMAAGGSAPELFTSLIGV 518

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304    156 cghgFIA-GDLGPSTIVGSAAFNMFIIIGICVYVipdgeTRKIKHLrvffitAAWSIFAYIWLY-----MILAVFSPGVV 229
Cdd:TIGR00927  519 ----FIShSNVGIGTIVGSAVFNILFVIGTCALF-----SREILNL------TWWPLFRDVSFYildlmMLILFFLDSLI 583

                          170       180
                   ....*....|....*....|.
gi 33946304    230 QVWEGLLTLFFFPVCVL-LAW 249
Cdd:TIGR00927  584 AWWESLLLLLAYALYVFtMKW 604
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
768-910 3.02e-09

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 59.38  E-value: 3.02e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304 768 DLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDvYADASIGNVTGSNAVNVFLGIGLAWSVAAIywalqgqe 847
Cdd:COG0530   6 RGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDG-SPDIAVGNVVGSNIANILLILGLAALIRPL-------- 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 33946304 848 fHVSAGTLAFSVTLFTIFAFVCISVLlyrrrphLGGELGGPRGcklattWLFVSLWLLYILFA 910
Cdd:COG0530  77 -AVDRRVLRRDLPFLLLASLLLLALL-------LDGTLSRIDG------VILLLLYVLYLYYL 125
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
136-254 8.15e-08

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 54.75  E-value: 8.15e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304 136 LTLMALGSSAPEILLSLIEVCGHgfiAGDLGPSTIVGSAAFNMFIIIGICVYVIPdgetRKIKHlRVFFITAAWSIFAYI 215
Cdd:COG0530  24 LTIVAFGTSLPELAVSVTAALDG---SPDIAVGNVVGSNIANILLILGLAALIRP----LAVDR-RVLRRDLPFLLLASL 95

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 33946304 216 WLymiLAVFSPGVVQVWEGLLTLFFFPVCVLLAWVADKR 254
Cdd:COG0530  96 LL---LALLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 82-243 1.09e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 51.56  E-value: 1.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304    82 VALIYMFLGVSII-ADRFMASIEVITSqerevTIKKPNgetstttirvwneTVSNLTLMALGSSAPEILLSLIEVCGHgf 160
Cdd:TIGR00367   4 IGYLILGLILLIYgADLFVKSSVRIAR-----HLGISP-------------LIIGVTVVAIGTSLPELFTSLIASLMG-- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   161 iAGDLGPSTIVGSAAFNMFIIIGICVYVIPdgetrkikhlrvfFITAAWSIF----AYIWLYMILAVFS-PGVVQVWEGL 235
Cdd:TIGR00367  64 -QPDIGVGNVIGSNIFNILLILGLSAIFSP-------------IIVDKDWLRrdilFYLLVSILLLFFGlDGQISRIDGV 129


                  ....*...
gi 33946304   236 LTLFFFPV 243
Cdd:TIGR00367 130 VLLILYIV 137
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 753-839 7.16e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 48.86  E-value: 7.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   753 AVSILIIGMLTAIIG-----DLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDvYADASIGNVTGSNAVNVF 827
Cdd:TIGR00367   3 LIGYLILGLILLIYGadlfvKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLMG-QPDIGVGNVIGSNIFNIL 81

                          90
                  ....*....|..
gi 33946304   828 LGIGLAWSVAAI 839
Cdd:TIGR00367  82 LILGLSAIFSPI 93
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 752-833 3.24e-05

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 46.95  E-value: 3.24e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304  752 FAVSILIIGMLTAIIGD-----LASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDvYADASIGNVTGSNAVNV 826
Cdd:PRK10734   3 LATALLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHG-QRDLAVGTALGSNITNI 81


                 ....*..
gi 33946304  827 FLGIGLA 833
Cdd:PRK10734  82 LLILGLA 88
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 752-834 7.64e-05

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 45.78  E-value: 7.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   752 FAVSILIIGMLTAIIG-----DLASHFGCTIGLKDSVTAVVFVAFGTSVPDTFASKAAALQDVyADASIGNVTGSNAVNV 826
Cdd:TIGR00367 170 FSLVLLIIGLIGLVVGsrllvDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGL-GDIAVGNVIGSNIFNI 248


                  ....*...
gi 33946304   827 FLGIGLAW 834
Cdd:TIGR00367 249 LVGLGVPS 256
PLN03151 PLN03151
cation/calcium exchanger; Provisional
 79-232 7.31e-04

cation/calcium exchanger; Provisional


Pssm-ID: 215604 [Multi-domain]  Cd Length: 650  Bit Score: 43.21  E-value: 7.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304   79 VYFVALIYMfLGvSIIADRFMASIEVITSqerevTIKKPngetstttirvwnETVSNLTLMALGSSAPEILLSLIEVCGH 158
Cdd:PLN03151 145 VWLVALFYL-LG-NTAADYFCCSLEKLSK-----LLRLP-------------PTVAGVTLLPLGNGAPDVFASIAAFVGK 204

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 33946304  159 GfiAGDLGPSTIVGSAAFNMFIIIGICVYVIPDGETRKIKhlRVFFITAAWSIFAYIWLYMILAVfspGVVQVW 232
Cdd:PLN03151 205 D--AGEVGLNSVLGGAVFVTCVVVGIVSLCVADKEVQIDK--RCFIRDLCFFLFTLVSLLVILMV---GKVTVG 271
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 753-909 9.32e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 42.33  E-value: 9.32e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304  753 AVSILIIGMLTAIIGD----LASHFGC---TIGLkdsvtavVFVAFGTSVPDTFASKAAALQDvYADASIGNVTGSNAVN 825
Cdd:PRK10734 180 GIALIIMPMATRMVIDnatvLANYFAIselTIGL-------TVIAIGTSLPELATAIAGARKG-ENDIAVGNIIGSNIFN 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304  826 VFLGIGLawsvAAIywaLQGQEFHVSAGTLAFSVTLFT--IFAFVCIsvllyrRRPHLGGELGGPRGCKLATTWLFVSLW 903
Cdd:PRK10734 252 IVIVLGL----PAL---ISPGEINPLAFSRDYWVMLLVsvIFALLCW------RRKRRIGRGAGALLLGGFIVWLAMLYW 318


                 ....*.
gi 33946304  904 LLYILF 909
Cdd:PRK10734 319 LSPILV 324
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
129-247 3.09e-03

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 40.50  E-value: 3.09e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33946304 129 WNETVSNLTLMALGSSAPEILLSLIEVC-GHGFIAgdLGpsTIVGSAAFNMFIIIGICVYVIPdgetrkikhLRVFFITA 207
Cdd:COG0530 184 VSELVIGLTIVAIGTSLPELATSIVAARkGEDDLA--VG--NIIGSNIFNILLVLGIGALITP---------IPVDPAVL 250

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 33946304 208 AWSIFAYI--WLYMILAVFSPGVVQVWEGLLTLFFFPVCVLL 247
Cdd:COG0530 251 SFDLPVMLaaTLLLLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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