BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187    1 MELPSYSQQLLLQLYALCKEQRFCDCTISVGNIYFRAHKPVLAAASLLFKTLLDSTDAISIDASVVSPEEFALLLEMTYT 80
Cdd:cd18225    1 MELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASVVSPEEFALLLEMVYT 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 38016187   81 GKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTNL 116
Cdd:cd18225   81 GKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTSL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187    1 MELPSYSQQLLLQLYALCKEQRFCDCTISVGNIYFRAHKPVLAAASLLFKTLLDSTDAISIDASVVSPEEFALLLEMTYT 80
Cdd:cd18225    1 MELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASVVSPEEFALLLEMVYT 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 38016187   81 GKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTNL 116
Cdd:cd18225   81 GKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTSL 116

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187      25 DCTISVGNIYFRAHKPVLAAASLLFKTLLDSTDAISIDASV----VSPEEFALLLEMTYTGKLPVGKHNFSKIISLADSL 100
Cdd:smart00225    1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIylddVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                            90
                    ....*....|...
gi 38016187     101 QMFDVAVSCKNLL 113
Cdd:smart00225   81 QIPGLVELCEEFL 93

Zinc-finger double domain;

                           10        20
                   ....*....|....*....|....*.
gi 38016187    925 ELSRHVRTHTGDKPYVCRDCGKGFRQ 950
Cdd:pfam13465    1 NLKRHMRTHTGEKPYKCPECGKSFKS 26

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 40 (ZBTB40); ZBTB40 may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB40 are associated with bone mineral density in European and East-Asian populations. ZBTB40 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187    1 MELPSYSQQLLLQLYALCKEQRFCDCTISVGNIYFRAHKPVLAAASLLFKTLLDSTDAISIDASVVSPEEFALLLEMTYT 80
Cdd:cd18225    1 MELPNYSRQLLQQLHTLRKEQQFCDCTIFIGTFHFRAHKLVLAASSLLFKSLLDSTDTISIDASVVSPEEFALLLEMVYT 80

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 38016187   81 GKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTNL 116
Cdd:cd18225   81 GKLPPGKHNFTKIISVADSLQMFDVAVSCKNLLTSL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   23 FCDCTISVGNIYFRAHKPVLAAASLLFKTLL------DSTDAISIDasVVSPEEFALLLEMTYTGKLPVGKHNFSKIISL 96
Cdd:cd18186    1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFssgmkeSSSSEIELD--DVSPEAFEALLDYIYTGELELSEENVEELLAA 78

                 ....
gi 38016187   97 ADSL 100
Cdd:cd18186   79 ADKL 82

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187     19 KEQRFCDCTISVGNIYFRAHKPVLAAASLLFKTLLDSTDAIS----IDASVVSPEEFALLLEMTYTGKLpVGKHNFSKII 94
Cdd:pfam00651    6 EQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESsvseITLDDVSPEDFEALLEFMYTGKL-ISEENVDDLL 84

                           90
                   ....*....|....*....
gi 38016187     95 SLADSLQMFDVAVSCKNLL 113
Cdd:pfam00651   85 AAADKLQIPSLVDKCEEFL 103

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   20 EQR----FCDCTISVGNIYFRAHKPVLAAASLLFKTLL-----DSTDAISIDASVVSPEEFALLLEMTYTGKLPVGKHNF 90
Cdd:cd18199   11 EQRkqdfFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLshyiqDTGRPSTASFDVFSSDAFSIILDFVYSGKLSLTSQNV 90

                         90       100
                 ....*....|....*....|
gi 38016187   91 SKIISLADSLQMFDVAVSCK 110
Cdd:cd18199   91 IEVMSAASYLQMTDVINVCK 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in hypermethylated in cancer 1 protein (Hic-1); Hic-1, also called zinc finger and BTB domain-containing protein 29 (ZBTB29), is a sequence-specific transcriptional repressor that recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. It may act as a tumor suppressor, and is involved in regulatory loops modulating P53-dependent and E2F1-dependent cell survival, growth control, and stress responses. It also regulates intestinal immunity and homeostasis. Hic-1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   23 FCDCTISVGNIYFRAHKPVLAAASLLFKTLLDSTDAISIDASVVSPEEFALLLEMTYTGKL----PVGKHNFSKIISLAD 98
Cdd:cd18333   21 LCDVIIVVQNALFRAHKNILAASSVYLKSLVVHDNLINLDHEMVSPGIFRLILDYIYTGRLsegdPGSEQNLGAVLAAAS 100

                         90
                 ....*....|....*
gi 38016187   99 SLQMFDVAVSCKNLL 113
Cdd:cd18333  101 YLQIPDLVALCKKKL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187    1 MELPSYSQQLLLQLyalcKEQR----FCDCTISVGNIYFRAHKPVLAAAS----LLFKTLLDSTDAISIDASVVSPEEFA 72
Cdd:cd18194    1 MEFPEHSRQLLQCL----REQRsqgfLCDCTVLVGSAQFPAHRAVLASCSmyfhLFYRDRLDKRDLVRLNSDIVTAPAFG 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 38016187   73 LLLEMTYTGKLPVGKHNFSKIISLADSLQMFDVAVSCKNLL 113
Cdd:cd18194   77 LLLDFMYEGRLALRDLPVEDVLAAASYLHMYDIVKVCKGRL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3); ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB3 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187    1 MELPSYSQQLLLQLyalcKEQR----FCDCTISVGNIYFRAHKPVLAAASLLF----KTLLDSTDAISIDASVVSPEEFA 72
Cdd:cd18323    1 MEFPDHSRHLLQSL----REQRhqgfLCDCTVLVGSTQFLAHRAVLASCSPFFhmfyKEQLDKRDLVCINNEIVTAPAFS 76

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 38016187   73 LLLEMTYTGKLPVGKHNFSKIISLADSLQMFDVAVSCKNLL 113
Cdd:cd18323   77 LLLEFMYEGRLSFNDTPVEDVLAAASYLHMNDIVKVCKKRL 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 10 (ZBTB10); ZBTB10, also called zinc finger protein RIN ZF, is an mRNA target of miR-27a and a transcriptional repressor of Specificity protein (Sp) expression. The microRNA-27a:ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2, and survivin expression in ovarian epithelial cancer cells. ZBTB10 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   20 EQR----FCDCTISVGNIYFRAHKPVLAAASLLFKTLLDSTDAISIDAS------VVSPEEFALLLEMTYTGKLPVGKHN 89
Cdd:cd18201   14 EQRkkgiLCDVNIVVSGKVFRAHKNILVAGSRFFKTLYCFTNKESCDQTtvthldVVAVQGFSVILDFMYSGNLVLTSQN 93

                         90       100
                 ....*....|....*....|....*....
gi 38016187   90 FSKIISLADSLQMFDVAVSCKNLLTNLVN 118
Cdd:cd18201   94 AIEVMSVASYLQMTEVVQSCRNFIKDALN 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 1 (ZBTB1); ZBTB1 acts as a transcriptional repressor that represses cAMP-responsive element (CRE)-mediated transcriptional activation. It also has a role in translesion DNA synthesis, and is essential for lymphocyte development. ZBTB1 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   24 CDCTISVGNIYFRAHKPVLAAASLLFKTLL----DSTDAISIDASVVSPEEFALLLEMTYTGKLPVGKHNFSKIISLADS 99
Cdd:cd18192   22 CDCCIAIDDIYFQAHKAVLAACSSYFRMMFinhqHTTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSDFEQLKVAMNY 101

                 ....*.
gi 38016187  100 LQMFDV 105
Cdd:cd18192  102 LQLYYI 107

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   19 KEQRFCDCTISVGNIYFRAHKPVLAAASLLFKTLLD------STDAISIDASVVSPEEFALLLEMTYTGKLPVGKHNFSK 92
Cdd:cd18245   10 EEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNynppkdDGSTYKIELEGISVEVMEEILDYIYTGQIKLSEDNIQD 89

                         90
                 ....*....|....*..
gi 38016187   93 IISLADSLQMFDVAVSC 109
Cdd:cd18245   90 IVQAADLLLMTDLKDLC 106

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   23 FCDCTISVGNIYFRAHKPVLAAASLLFKTL-LDSTDAISIDASVVSpeEFALLLEMTYTGKLPVGKHNFSKIISLADSLQ 101
Cdd:cd18206   22 LCDCTFVVDGVDFKAHKAVLAACSEYFRMLfVDQKDVVHLDISNAA--GLGQVLEFMYTAKLSLSPENVDDVLAVATFLQ 99

                         90
                 ....*....|.
gi 38016187  102 MFDVAVSCKNL 112
Cdd:cd18206  100 MQDIVTACHAL 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   17 LCKEQRFCDCTISVGNIYFRAHKPVLAAASLLFKTLLdsTDAISIDASVVSPEE-------------FALLLEMTYTGKL 83
Cdd:cd18228   13 LRNEGHFCDVTIRVQDKIFRAHKVVLAACSDFFRSKL--VGQASPRLVLVSPAGkcvldlhhvtvtgFAPLLEYAYTSTL 90

                         90       100
                 ....*....|....*....|....*.
gi 38016187   84 PVGKHNFSKIISLADSLQMFDVAVSC 109
Cdd:cd18228   91 SINTENIIDVLAAASYMQMFNVANTC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in telomere zinc finger-associated protein (TZAP); TZAP is also called Krueppel-related zinc finger protein 3 (KR3), zinc finger and BTB domain-containing protein 48 (ZBTB48), or zinc finger protein 855 (ZNF855). It is a vertebrate telomere-binding protein involved in telomere length control. It directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat. TZAP also acts as a transcription regulator that binds to promoter regions. It is a transcriptional activator of alternate reading frame (ARF) gene. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   20 EQRFCDCTISVGNIYFRAHKPVLAAASLLFKTLLDSTDAISIDASVVSPEEFALLLEMTYTGKLPVGKHNFSKIISLADS 99
Cdd:cd18232   15 EGQYCDATLDVGGRVFKAHWSVLACCSHFFQSLYGDGTSGSVVLPESFAEVFGLLLDFFYTGELALTRENRDRVLLAAKE 94

                         90
                 ....*....|.
gi 38016187  100 LQMFDVAVSCK 110
Cdd:cd18232   95 LRVPEAVELCQ 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 42 (ZBTB42); ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. It is enriched in skeletal muscles, especially at the neuromuscular junction. A ZBTB42 mutation has been identified to define a novel lethal congenital contracture syndrome (LCCS6), a lethal autosomal recessive form of arthrogryposis multiplex congenita (AMC). ZBTB42 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   19 KEQR----FCDCTISVGNIYFRAHKPVLAAASLLFKTLL-----DSTDAISIDASVVSPEEFALLLEMTYTGKLPVGKHN 89
Cdd:cd18956   15 RQQRelgfLCDCTVLVGDARFPAHRAVLAACSVYFHLFYrdrpaGGRDTVRLNGDIVTAPAFGRLLDFMYEGRLDLRSLP 94

                         90       100
                 ....*....|....*....|....
gi 38016187   90 FSKIISLADSLQMFDVAVSCKNLL 113
Cdd:cd18956   95 VEDVLAAASYLHMYDIVKVCKGRL 118

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   23 FCDCTISVGNIYFRAHKPVLAAASLLFKTLLDSTDA-----ISIDAsvVSPEEFALLLEMTYTGKLPVGKHNFSKIISLA 97
Cdd:cd18315    1 LVDVTLACEGGSLKAHKLVLAAASPYFAALLKETPPdehpvIILPD--VPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78

                 ....
gi 38016187   98 DSLQ 101
Cdd:cd18315   79 ELLQ 82

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 43 (ZBTB43); ZBTB43, also called zinc finger and BTB domain-containing protein 22B (ZBTB22b), zinc finger protein 297B (ZNF297B), or ZnF-x, may be involved in transcriptional regulation. It interacts with BDP1, a subunit of transcription factor IIIB (TFIIIB). Since BDP1 is essential in Pol III transcription, ZBTB43 may also regulate these transcriptional pathways. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187    1 MELPSYSQQLLLQLYALCKEQRFCDCTISVGNIYFRAHKPVLAAASLLF--KTLLDSTDAISIdASVVSPEEFALLLEMT 78
Cdd:cd18227    3 VEFPDFSSTILQKLNQQRQQGQLCDISVVVQGHLFRAHKAVLAASSPYFcdQVLLKNSRRIVL-PDVMNPRVFENILLSC 81

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 38016187   79 YTGKLPVGKHNFSKIISLADSLQMFDVAVSCKNLL 113
Cdd:cd18227   82 YTGRLVLPAPEIVSYLTAASFLQMWHVVDKCTELL 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 2 (ZBTB2); ZBTB2 is a POZ domain Kruppel-like zinc finger (POK) family transcription factor acting as a potent repressor of the ARF-HDM2-p53-p21 pathway, which is important in cell cycle regulation. It represses transcription of the ARF, p53, and p21 genes, but activates the HDM2 gene. ZBTB2 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38016187   23 FCDCTISVGNIYFRAHKPVLAAASLLFKTLL--DSTDAISIDASVVSPEEFALLLEMTYTGKL 83
Cdd:cd18193   21 LCDCTVAIGDVYFKAHKSVLASFSNYFKMLFvhQTSECVRLKPTDIQPDIFSYLLHLMYTGKM 83

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP); NS1-BP is also called NS1-binding protein, aryl hydrocarbon receptor-associated protein 3 (ARA3), or IVNS1ABP. It is a novel protein that interacts with the influenza A virus nonstructural NS1 protein, which is relocalized in the nuclei of infected cells. It plays a role in cell division and in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through its kelch repeats. It also interacts with alpha-enolase/MBP-1 and is involved in c-Myc gene transcriptional control. NS1-BP contains BTB and BACK domains at the N-terminal region and kelch repeats at the C-terminal region. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   16 ALCKEQRFCDCTISVGNIYFRAHKPVLAAAS----LLFKTLLDSTDAISIDASVVSPEEFALLLEMTYTGKLPVGKHNFS 91
Cdd:cd18306   11 ALRKNRQFCDVILQVGGHEIPAHRAVLACASpylfELFSSDSDGESILTVKLDGLDPDAVEVLVNYAYTSRLEVPADLVK 90

                         90       100       110
                 ....*....|....*....|....*....|.
gi 38016187   92 KIISLADSLQMFDVAVSCKN-LLTNLV--NC 119
Cdd:cd18306   91 SVYSAAKKLKMDRVKKACGDfLLEKLTpqNC 121

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 22 (ZBTB22); ZBTB22, also called protein BING1 or zinc finger protein 297, may be involved in transcriptional regulation. Its gene, together with BING 3-5, TAPASIN, DAXX, RGL2, and HKE2, form a dense cluster at the centromeric end of the major histocompatibility complex class I region. ZBTB22 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   20 EQRFCDCTISVGNIYFRAHKPVLAAASLLF--KTLLDSTDAISIdASVVSPEEFALLLEMTYTGKLPVGKHNFSKIISLA 97
Cdd:cd18210   18 EGKLCDISIHVQGRVFRAHRAVLAASSPYFhdQVLLKNMSSISL-PGVMDPGAFESVLASAYTGKLTMLADEIVNYLTVG 96

                         90
                 ....*....|....*.
gi 38016187   98 DSLQMFDVAVSCKNLL 113
Cdd:cd18210   97 SVLQMWHIVDKCTELL 112

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12); KLHL12, also called CUL3-interacting protein 1 (C3IP1) or DKIR homolog, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a negative regulator of the Wnt signaling pathway and ER-Golgi transport. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187    5 SYSQQLLLQLYALCKEQRFCDCTISVGNIYFRAHKPVLAAAS----LLFKTLLDSTDAISIDASVVSPEEFALLLEMTYT 80
Cdd:cd18242    3 SHAKSILNTMNSLRKSNTLCDVTLRVEGKEFPAHRIVLAACSdyfcAMFTSEMSEKGKSEVELQGLTASTMEILLDFVYT 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 38016187   81 GKLPVGKHNFSKIISLADSLQMFDVAVSCKNLLTNLVNCS 120
Cdd:cd18242   83 ETVHVTVENVQELLPAACLLQLKGVKQACCEFLESQLDPS 122

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 46 (ZBTB46); ZBTB46 is also called BTB-ZF protein expressed in effector lymphocytes (BZEL), BTB/POZ domain-containing protein 4 (BTBD4), or zinc finger protein 340 (ZNF340). It is a conventional dendritic cell (cDC) lineage specific transcription factor that acts as a negative regulator required to prevent activation of classical dendritic cells in the steady state. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   20 EQR----FCDCTISVGNIYFRAHKPVLAAASLLFKTLLDSTDAISIDASV-----VSPEEFALLLEMTYTGKLPVGKHNF 90
Cdd:cd18230   14 EQRqhgiLCDVCIIVEGKIFKAHKNVLLGSSRYFKTLYCQVQKTSDQATVthldiVTAQGFKAIIDFMYSAHLALTSKNV 93

                         90       100       110
                 ....*....|....*....|....*....|..
gi 38016187   91 SKIISLADSLQMFDVAVSCKNLLTNLVNCSVQ 122
Cdd:cd18230   94 IEVMSAASYLQMTDIVQACHNFIKAALDISIK 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   19 KEQRFCDCTISVGNIYFRAHKPVLAAASLLFKTLLdsTDAISIDASVVS------PEEFALLLEMTYTGKLPVGKHNFSK 92
Cdd:cd18215   15 SRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIF--TDQLKNNVSVINldpeiePEGFRILLDFMYTSRLNLREGNIMA 92

                         90
                 ....*....|....*..
gi 38016187   93 IISLADSLQMFDVAVSC 109
Cdd:cd18215   93 VMATAMYLQMEHVVDTC 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   24 CDCTISVGNIYFRAHKPVLAAASLLF-KTLLDSTDAisiDASVVSPEE-----FALLLEMTYTGKLPVGKHNFSKIISLA 97
Cdd:cd18955    2 CDVTIVVEDQRFRAHRAVLAACSDYFlSRVVGQTDG---DLVITLPEEvtvkgFEPLLQFAYTAKLLLSKENVLEVCRCA 78

                         90
                 ....*....|....*.
gi 38016187   98 DSLQMFDVAVSCKNLL 113
Cdd:cd18955   79 EFLGVHNIEKACFDFL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in nucleus accumbens-associated protein 2 (NAC-2); NAC-2, also called BTB/POZ domain-containing protein 14A (BTBD14A) or repressor with BTB domain and BEN domain (RBB), is a novel transcription repressor through its association with the NuRD complex. It recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   20 EQR----FCDCTISVGNIYFRAHKPVLAAASLLFKTLL--DSTDAISIDASvVSPEEFALLLEMTYTGKL 83
Cdd:cd18289   22 EQRlmglYCDVSIVVKGQAFKAHRAVLAASSLYFRDLFsgNSKSAFELPAT-VPPACFQQILSFCYTGKL 90

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 47 (ZBTB47); ZBTB47, also called zinc finger protein 651 (ZNF651), is a paralog of ZNF652, a novel zinc-finger transcriptional repressor. It interacts with CBFA2T3 via its carboxy-terminal proline-rich region. CBFA2T3-ZNF651 functions as a transcriptional co-repressor complex. ZBTB47 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38016187   20 EQRF-----CDCTISVG--NIYFRAHKPVLAAASLLFKTLLDSTDAI-----SIDAsvVSPEEFALLLEMTYTGKLPVGK 87
Cdd:cd18231    6 EQRLfqpdlCDVDIVLVrqRSTFPAHKGVLAAYSQFFHSLFTQNKQLqrvelSLEA--LTSQGLQQILNFIYTSKLLVNS 83

                         90       100
                 ....*....|....*....|....*...
gi 38016187   88 HNFSKIISLADSLQMFDVAVSCKNLLTN 115
Cdd:cd18231   84 CNVQDVLNAAAVLQMNDIAASCQELIDS 111