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Conserved domains on  [gi|38505290|ref|NP_938202|]
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voltage-dependent T-type calcium channel subunit alpha-1G isoform 13 [Homo sapiens]

Protein Classification

ion transporter( domain architecture ID 11997982)

ion transporter such as a voltage-gated cation channel, which enables the selective translocation of cations such as sodium, calcium, or potassium, across cell membranes

Gene Ontology:  GO:0034220|GO:0005216
PubMed:  15816170
TCDB:  1.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-968 9.38e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 220.22  E-value: 9.38e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    742 SKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKLLVYGPFG-YIKNPYNIFDGVIVVISV 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    820 WEIV---GQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD 896
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38505290    897 GDtlPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS-WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Cdd:pfam00520  161 PD--NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1252-1524 1.81e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 190.94  E-value: 1.81e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1252 HKMFDHVVLVIIFLNCITIAMERPKIdPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFgeqAYLRSSWNVLDGLLV 1331
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQ-PEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1332 LISVIDILVSMVSdsgtkILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1411
Cdd:pfam00520   77 LPSLISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLF 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1412 KGKFFVCQGEDTRNitnksdcaeasyrwvrhkYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGvdqqpimnhNPWML 1491
Cdd:pfam00520  152 GGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAY 204
                          250       260       270
                   ....*....|....*....|....*....|...
gi 38505290   1492 LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Cdd:pfam00520  205 IYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1569-1810 3.59e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 178.23  E-value: 3.59e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1569 SHYLDLFITGVIGLNVVTMAMEHYQQPQ-ILDEALKICNYIFTVIFVLESVFKLVAFGF-RRFFQDRWNQLDLAIVLLSI 1646
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1647 MGITLEEIEvnaslpiNPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1726
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1727 lecDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDqestcynTVISPIYFVSFVLTAQFVLVNVVI 1806
Cdd:pfam00520  154 ---KLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------EFWAYIYFVSFIILGGFLLLNLFI 223

                   ....
gi 38505290   1807 AVLM 1810
Cdd:pfam00520  224 AVII 227
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
80-406 2.61e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 155.89  E-value: 2.61e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290     80 NPWFERISMLVILLNCVTLGMFRPCEDiacDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIfgKKCYLGDTWNRLDFFI 159
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP---EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    160 VIAGMLEYSLDLQN--VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCffvffifgivgvqLWAGLL 237
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL-------------LLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    238 rnrcflpenFSLplsvdleryyqtenedespficsqpreNGMrscrsvptlrgdggggppcgldyeaynsssnttcvnwn 317
Cdd:pfam00520  143 ---------FAI---------------------------IGY-------------------------------------- 148
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Cdd:pfam00520  149 QLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228
                          330
                   ....*....|
gi 38505290    397 QFSETKQRES 406
Cdd:pfam00520  229 NFQELTERTE 238
PHA03247 super family cl33720
large tegument protein UL36; Provisional
1839-2222 1.24e-05

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  1839 PQPHSPLGspflwPGVEGPDSPDSPKPGALHPAAHARSASHfslehPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSY 1918
Cdd:PHA03247 2593 PQSARPRA-----PVDDRGDPRGPAPPSPLPPDTHAPDPPP-----PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS 2662
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  1919 MCRHGSTAEGPLGH----RGWGLPKAQS--GSVLSVHSQPADTsyilQLPKDAPHLLQP------------HSAPTWGTI 1980
Cdd:PHA03247 2663 RPRRARRLGRAAQAssppQRPRRRAARPtvGSLTSLADPPPPP----PTPEPAPHALVSatplppgpaaarQASPALPAA 2738
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  1981 PKLPPPGRSPLAQRPLRRQAAIRTDSldvqGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPP 2060
Cdd:PHA03247 2739 PAPPAVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP 2814
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  2061 APCPGPEPNWGKGPPETRSSLEldtelswiSGDLLPPGgqeepPSPRDLKKCYSV-EAQSCQRRPTSWLDEQRRHSIAVS 2139
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQP--------TAPPPPPG-----PPPPSLPLGGSVaPGGDVRRRPPSRSPAAKPAAPARP 2881
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  2140 CLDSGSQPHLgtDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMA 2219
Cdd:PHA03247 2882 PVRRLARPAV--SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV 2959

                  ...
gi 38505290  2220 ASP 2222
Cdd:PHA03247 2960 PQP 2962
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-968 9.38e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 220.22  E-value: 9.38e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    742 SKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKLLVYGPFG-YIKNPYNIFDGVIVVISV 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    820 WEIV---GQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD 896
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38505290    897 GDtlPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS-WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Cdd:pfam00520  161 PD--NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1252-1524 1.81e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 190.94  E-value: 1.81e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1252 HKMFDHVVLVIIFLNCITIAMERPKIdPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFgeqAYLRSSWNVLDGLLV 1331
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQ-PEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1332 LISVIDILVSMVSdsgtkILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1411
Cdd:pfam00520   77 LPSLISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLF 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1412 KGKFFVCQGEDTRNitnksdcaeasyrwvrhkYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGvdqqpimnhNPWML 1491
Cdd:pfam00520  152 GGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAY 204
                          250       260       270
                   ....*....|....*....|....*....|...
gi 38505290   1492 LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Cdd:pfam00520  205 IYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1569-1810 3.59e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 178.23  E-value: 3.59e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1569 SHYLDLFITGVIGLNVVTMAMEHYQQPQ-ILDEALKICNYIFTVIFVLESVFKLVAFGF-RRFFQDRWNQLDLAIVLLSI 1646
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1647 MGITLEEIEvnaslpiNPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1726
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1727 lecDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDqestcynTVISPIYFVSFVLTAQFVLVNVVI 1806
Cdd:pfam00520  154 ---KLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------EFWAYIYFVSFIILGGFLLLNLFI 223

                   ....
gi 38505290   1807 AVLM 1810
Cdd:pfam00520  224 AVII 227
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
80-406 2.61e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 155.89  E-value: 2.61e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290     80 NPWFERISMLVILLNCVTLGMFRPCEDiacDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIfgKKCYLGDTWNRLDFFI 159
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP---EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    160 VIAGMLEYSLDLQN--VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCffvffifgivgvqLWAGLL 237
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL-------------LLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    238 rnrcflpenFSLplsvdleryyqtenedespficsqpreNGMrscrsvptlrgdggggppcgldyeaynsssnttcvnwn 317
Cdd:pfam00520  143 ---------FAI---------------------------IGY-------------------------------------- 148
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Cdd:pfam00520  149 QLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228
                          330
                   ....*....|
gi 38505290    397 QFSETKQRES 406
Cdd:pfam00520  229 NFQELTERTE 238
PHA03247 PHA03247
large tegument protein UL36; Provisional
1839-2222 1.24e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  1839 PQPHSPLGspflwPGVEGPDSPDSPKPGALHPAAHARSASHfslehPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSY 1918
Cdd:PHA03247 2593 PQSARPRA-----PVDDRGDPRGPAPPSPLPPDTHAPDPPP-----PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS 2662
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  1919 MCRHGSTAEGPLGH----RGWGLPKAQS--GSVLSVHSQPADTsyilQLPKDAPHLLQP------------HSAPTWGTI 1980
Cdd:PHA03247 2663 RPRRARRLGRAAQAssppQRPRRRAARPtvGSLTSLADPPPPP----PTPEPAPHALVSatplppgpaaarQASPALPAA 2738
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  1981 PKLPPPGRSPLAQRPLRRQAAIRTDSldvqGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPP 2060
Cdd:PHA03247 2739 PAPPAVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP 2814
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  2061 APCPGPEPNWGKGPPETRSSLEldtelswiSGDLLPPGgqeepPSPRDLKKCYSV-EAQSCQRRPTSWLDEQRRHSIAVS 2139
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQP--------TAPPPPPG-----PPPPSLPLGGSVaPGGDVRRRPPSRSPAAKPAAPARP 2881
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  2140 CLDSGSQPHLgtDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMA 2219
Cdd:PHA03247 2882 PVRRLARPAV--SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV 2959

                  ...
gi 38505290  2220 ASP 2222
Cdd:PHA03247 2960 PQP 2962
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
838-978 1.86e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 43.78  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   838 LMRVLKLVRFLPalqrQLVVLMKTMD-NVATFCMLLMLFIFIF---SILGMHLFGckFASErdgdtlpdrkNFDSLLWAI 913
Cdd:PLN03223 1303 LGRILKLMDFQP----RLGVITRTLWlAGADLMHFFVIFGMVFvgyAFIGHVIFG--NASV----------HFSDMTDSI 1366
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38505290   914 VTVFQILTQE--DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFqAEGDANKSES 978
Cdd:PLN03223 1367 NSLFENLLGDitYFNEDLKNLTGLQFVVGMIYFYSYNIFVFMILFNFLLAIICDAF-GEVKANAAET 1432
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
742-968 9.38e-65

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 220.22  E-value: 9.38e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    742 SKYFGRGIMIAILVNTLSMGIEYHEQPEE-LTNALEISNIVFTSLFALEMLLKLLVYGPFG-YIKNPYNIFDGVIVVISV 819
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKrYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    820 WEIV---GQQGGGLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFASERD 896
Cdd:pfam00520   81 ISLVlssVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWEN 160
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 38505290    897 GDtlPDRKNFDSLLWAIVTVFQILTQEDWNKVLYNGMASTSS-WAALYFIALMTFGNYVLFNLLVAILVEGFQ 968
Cdd:pfam00520  161 PD--NGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGEfWAYIYFVSFIILGGFLLLNLFIAVIIDNFQ 231
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1252-1524 1.81e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 190.94  E-value: 1.81e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1252 HKMFDHVVLVIIFLNCITIAMERPKIdPHSAERIFLTLSNYIFTAVFLAEMTVKVVALGWCFgeqAYLRSSWNVLDGLLV 1331
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQ-PEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKK---RYFRSPWNILDFVVV 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1332 LISVIDILVSMVSdsgtkILGMLRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLF 1411
Cdd:pfam00520   77 LPSLISLVLSSVG-----SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLF 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1412 KGKFFVCQGEDTRNitnksdcaeasyrwvrhkYNFDNLGQALMSLFVLASKDGWVDIMYDGLDAVGvdqqpimnhNPWML 1491
Cdd:pfam00520  152 GGKLKTWENPDNGR------------------TNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG---------EFWAY 204
                          250       260       270
                   ....*....|....*....|....*....|...
gi 38505290   1492 LYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQ 1524
Cdd:pfam00520  205 IYFVSFIILGGFLLLNLFIAVIIDNFQELTERT 237
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
1569-1810 3.59e-50

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 178.23  E-value: 3.59e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1569 SHYLDLFITGVIGLNVVTMAMEHYQQPQ-ILDEALKICNYIFTVIFVLESVFKLVAFGF-RRFFQDRWNQLDLAIVLLSI 1646
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1647 MGITLEEIEvnaslpiNPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGD 1726
Cdd:pfam00520   81 ISLVLSSVG-------SLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGG 153
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1727 lecDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLRDCDqestcynTVISPIYFVSFVLTAQFVLVNVVI 1806
Cdd:pfam00520  154 ---KLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG-------EFWAYIYFVSFIILGGFLLLNLFI 223

                   ....
gi 38505290   1807 AVLM 1810
Cdd:pfam00520  224 AVII 227
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
80-406 2.61e-42

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 425730 [Multi-domain]  Cd Length: 238  Bit Score: 155.89  E-value: 2.61e-42
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290     80 NPWFERISMLVILLNCVTLGMFRPCEDiacDSQRCRILQAFDDFIFAFFAVEMVVKMVALGIfgKKCYLGDTWNRLDFFI 159
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP---EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGF--KKRYFRSPWNILDFVV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    160 VIAGMLEYSLDLQN--VSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCffvffifgivgvqLWAGLL 237
Cdd:pfam00520   76 VLPSLISLVLSSVGslSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLL-------------LLFLFI 142
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    238 rnrcflpenFSLplsvdleryyqtenedespficsqpreNGMrscrsvptlrgdggggppcgldyeaynsssnttcvnwn 317
Cdd:pfam00520  143 ---------FAI---------------------------IGY-------------------------------------- 148
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    318 QYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIAT 396
Cdd:pfam00520  149 QLFGGKLKTWENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGkGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228
                          330
                   ....*....|
gi 38505290    397 QFSETKQRES 406
Cdd:pfam00520  229 NFQELTERTE 238
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
1604-1815 7.54e-08

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 57.35  E-value: 7.54e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1604 ICNYIFTVIFVLESVFKLVAFGfRRFFQDRWNQLDLAIVLLSIMGITL---EEIEVNA---SLPINP------------- 1664
Cdd:pfam08016  214 IVFVVFFLYFVVEEILKIRKHR-PSYLRSVWNLLDLAIVILSVVLIVLniyRDFLVDRlikSVEASPvtfidfdrvaqld 292
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   1665 TIIRIMR----VLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGLLFMLLFFIFAALGVELFGdlecdeTHpceglgr 1740
Cdd:pfam08016  293 NLYRIILaflvFLTWLKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFG------TQ------- 359
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38505290   1741 HATFRNFGMAFLTLFRVSTGD-NWNGIMKDtlrdcdqestcyNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEE 1815
Cdd:pfam08016  360 APNFSNFVKSILTLFRTILGDfGYNEIFSG------------NRVLGPLLFLTFVFLVIFILLNLFLAIINDSYVE 423
PHA03247 PHA03247
large tegument protein UL36; Provisional
1839-2222 1.24e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.71  E-value: 1.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  1839 PQPHSPLGspflwPGVEGPDSPDSPKPGALHPAAHARSASHfslehPTMQPHPTELPGPDLLTVRKSGVSRTHSLPNDSY 1918
Cdd:PHA03247 2593 PQSARPRA-----PVDDRGDPRGPAPPSPLPPDTHAPDPPP-----PSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVS 2662
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  1919 MCRHGSTAEGPLGH----RGWGLPKAQS--GSVLSVHSQPADTsyilQLPKDAPHLLQP------------HSAPTWGTI 1980
Cdd:PHA03247 2663 RPRRARRLGRAAQAssppQRPRRRAARPtvGSLTSLADPPPPP----PTPEPAPHALVSatplppgpaaarQASPALPAA 2738
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  1981 PKLPPPGRSPLAQRPLRRQAAIRTDSldvqGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPP 2060
Cdd:PHA03247 2739 PAPPAVPAGPATPGGPARPARPPTTA----GPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAP 2814
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  2061 APCPGPEPNWGKGPPETRSSLEldtelswiSGDLLPPGgqeepPSPRDLKKCYSV-EAQSCQRRPTSWLDEQRRHSIAVS 2139
Cdd:PHA03247 2815 AAALPPAASPAGPLPPPTSAQP--------TAPPPPPG-----PPPPSLPLGGSVaPGGDVRRRPPSRSPAAKPAAPARP 2881
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  2140 CLDSGSQPHLgtDPSNLGGQPLGGPGSRPKKKLSPPSITIDPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMA 2219
Cdd:PHA03247 2882 PVRRLARPAV--SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAV 2959

                  ...
gi 38505290  2220 ASP 2222
Cdd:PHA03247 2960 PQP 2962
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
1857-2243 4.17e-05

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 49.01  E-value: 4.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  1857 PDSPDSPKPGALHPAAHARSASHFSLEHPTM---QPHPTELPGPDLLTvRKSGVSRT-------HSLPNDSYMCRHGSTA 1926
Cdd:PHA03307   65 FEPPTGPPPGPGTEAPANESRSTPTWSLSTLapaSPAREGSPTPPGPS-SPDPPPPTpppasppPSPAPDLSEMLRPVGS 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  1927 EGPLGHRGWGLPKAQSGSVLSVHSQPADTSYILQLPKDAPHLLQPHSAPtwgtIPKLPPPGRSPLAQRPLRRQAAIRTDS 2006
Cdd:PHA03307  144 PGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAE----PPPSTPPAAASPRPPRRSSPISASASS 219
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  2007 LDVQGLGSREDLLAEVSGPSPPLARAYSFWGQSSTQAQQHSRSHSKISKHMTPPAPCPGPEpnwGKGPPETRSSlelDTE 2086
Cdd:PHA03307  220 PAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSS---RPGPASSSSS---PRE 293
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290  2087 LSwisGDLLP--PGGQEEPPSPRdlkkcySVEAQScqRRPTSWLDEQRRHSIAVSCLDSGSQPHLGTDPSNLGGQPLGGP 2164
Cdd:PHA03307  294 RS---PSPSPssPGSGPAPSSPR------ASSSSS--SSRESSSSSTSSSSESSRGAAVSPGPSPSRSPSPSRPPPPADP 362
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 38505290  2165 GSRPKKklSPPSitidPPESQGPRTPPSPGICLRRRAPSSDSKDPLASGPPDSMAASPSPKKDVLSLSGLSSDPADLDP 2243
Cdd:PHA03307  363 SSPRKR--PRPS----RAPSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAASGAFYARYPLLTP 435
PLN03223 PLN03223
Polycystin cation channel protein; Provisional
838-978 1.86e-03

Polycystin cation channel protein; Provisional


Pssm-ID: 215637 [Multi-domain]  Cd Length: 1634  Bit Score: 43.78  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290   838 LMRVLKLVRFLPalqrQLVVLMKTMD-NVATFCMLLMLFIFIF---SILGMHLFGckFASErdgdtlpdrkNFDSLLWAI 913
Cdd:PLN03223 1303 LGRILKLMDFQP----RLGVITRTLWlAGADLMHFFVIFGMVFvgyAFIGHVIFG--NASV----------HFSDMTDSI 1366
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 38505290   914 VTVFQILTQE--DWNKVLYNGMASTSSWAALYFIALMTFGNYVLFNLLVAILVEGFqAEGDANKSES 978
Cdd:PLN03223 1367 NSLFENLLGDitYFNEDLKNLTGLQFVVGMIYFYSYNIFVFMILFNFLLAIICDAF-GEVKANAAET 1432
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 ...
838-967 2.69e-03

Polycystin cation channel; This family contains the cation channel region of PKD1 and PKD2 proteins.


Pssm-ID: 400395  Cd Length: 424  Bit Score: 42.72  E-value: 2.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38505290    838 LMRVLKLVRFlpalQRQLVVLMKTM----DNVATFCMLLMLFIFIFSILGMHLFGCKFAserdgdtlpdrkNFDSLLWAI 913
Cdd:pfam08016  307 WLKLFKVLRF----NKTMSLFTKTLsrawKDLAGFALMFVIFFFAYAQFGYLLFGTQAP------------NFSNFVKSI 370
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 38505290    914 VTVFQILtqedWNKVLYNGMASTSSW-AALYFIALMTFGNYVLFNLLVAILVEGF 967
Cdd:pfam08016  371 LTLFRTI----LGDFGYNEIFSGNRVlGPLLFLTFVFLVIFILLNLFLAIINDSY 421
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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