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Conserved domains on  [gi|38348408|ref|NP_940968|]
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uncharacterized protein C5orf34 [Homo sapiens]

Protein Classification

DUF4524 and DUF4520 domain-containing protein( domain architecture ID 10633249)

DUF4524 and DUF4520 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4524 pfam15025
Domain of unknown function (DUF4524); This family of proteins is found in eukaryotes. Proteins ...
 7-152 2.95e-78

Domain of unknown function (DUF4524); This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the N-terminal domain of the member proteins. The human gene is from C5orf34.


:

Pssm-ID: 464454  Cd Length: 146  Bit Score: 244.92  E-value: 2.95e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348408     7 MILYEDDSVQVQYVDGSTLQLSPCGSEFLFEKSPPVSAHPLEQPERIRQRTHFVISTYREQLQRALDFRNSSATCPFLSE 86
Cdd:pfam15025   1 MVLYEDDSVEVHFSDGSRLQLSPCGSEFLFEKADPPSAHPLQPGERVRQRTRFAISRYKPLLAAALEFRNQYAERPYLPE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38348408    87 TIIPSERKKHIFIDITEVRWPSLDTDGTMIYMESGIVKITSLDGHAYLCLPRSQHEFTVHFLCKVS 152
Cdd:pfam15025  81 EIIPSEKKKRLGSDISEAKWPSSSSSGLVTRGDGGSVTVSSEDGAAQLVLSPHQEEFTVEFLCKVS 146
DUF4520 pfam15016
Domain of unknown function (DUF4520); This family of proteins is found in eukaryotes. Proteins ...
 447-538 2.20e-41

Domain of unknown function (DUF4520); This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the C-terminal domain of the member proteins.


:

Pssm-ID: 434393  Cd Length: 89  Bit Score: 144.79  E-value: 2.20e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348408   447 ILPLVLKESLIPSVGRFLAYSDDKVHAIFLDGITLTLNWNFSSpiEKRQVNqGLNLGWCKLTFPDGQEQLIQIEHPEPYE 526
Cdd:pfam15016   1 MSPVVLEESTIPGIGRFTAYSDGRVHVHFDDRTILTLVWDFSS--GKTQVN-RESTGWCKLLLPDGQQVLVRIEHPGHYE 77

                          90
                  ....*....|..
gi 38348408   527 RYVTTVTSWCRR 538
Cdd:pfam15016  78 RYVAAALEFCRW 89
 
Name Accession Description Interval E-value
DUF4524 pfam15025
Domain of unknown function (DUF4524); This family of proteins is found in eukaryotes. Proteins ...
 7-152 2.95e-78

Domain of unknown function (DUF4524); This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the N-terminal domain of the member proteins. The human gene is from C5orf34.


Pssm-ID: 464454  Cd Length: 146  Bit Score: 244.92  E-value: 2.95e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348408     7 MILYEDDSVQVQYVDGSTLQLSPCGSEFLFEKSPPVSAHPLEQPERIRQRTHFVISTYREQLQRALDFRNSSATCPFLSE 86
Cdd:pfam15025   1 MVLYEDDSVEVHFSDGSRLQLSPCGSEFLFEKADPPSAHPLQPGERVRQRTRFAISRYKPLLAAALEFRNQYAERPYLPE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38348408    87 TIIPSERKKHIFIDITEVRWPSLDTDGTMIYMESGIVKITSLDGHAYLCLPRSQHEFTVHFLCKVS 152
Cdd:pfam15025  81 EIIPSEKKKRLGSDISEAKWPSSSSSGLVTRGDGGSVTVSSEDGAAQLVLSPHQEEFTVEFLCKVS 146
DUF4520 pfam15016
Domain of unknown function (DUF4520); This family of proteins is found in eukaryotes. Proteins ...
 447-538 2.20e-41

Domain of unknown function (DUF4520); This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the C-terminal domain of the member proteins.


Pssm-ID: 434393  Cd Length: 89  Bit Score: 144.79  E-value: 2.20e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348408   447 ILPLVLKESLIPSVGRFLAYSDDKVHAIFLDGITLTLNWNFSSpiEKRQVNqGLNLGWCKLTFPDGQEQLIQIEHPEPYE 526
Cdd:pfam15016   1 MSPVVLEESTIPGIGRFTAYSDGRVHVHFDDRTILTLVWDFSS--GKTQVN-RESTGWCKLLLPDGQQVLVRIEHPGHYE 77

                          90
                  ....*....|..
gi 38348408   527 RYVTTVTSWCRR 538
Cdd:pfam15016  78 RYVAAALEFCRW 89
POLO_box_Plk4_3 cd13116
C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak); The polo-like Ser ...
 15-56 7.01e-03

C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak); The polo-like Ser/Thr kinases (Plk1, Plk2/Snk, Plk3/Prk/Fnk, Plk4/Sak, and the inactive kinase Plk5) play various roles in cytokinesis and mitosis. At their C-terminus, they contain a tandemly repeated polo-box domain (in the case of Plk4, a tandem repeat of cryptic PBDs is found in the middle of the protein followed by a C-terminal single repeat), which appears to be involved in autoinhibition and in mediating the subcellular localization. The latter may be controlled via interactions between the polo-box domain and phospho-peptide motifs. The phosphopeptide binding site is formed at the interface between the two tandemly repeated PBDs. The PBDs of Plk4/Sak appear unique in participating in homodimer interactions, though it is not clear whether and how they interact with phosphopeptides.


Pssm-ID: 240559  Cd Length: 81  Bit Score: 36.03  E-value: 7.01e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 38348408  15 VQVQYVDGSTLQLSP-CGSEFLFEKSPPVSAHPLEQ---PERIRQR 56
Cdd:cd13116  24 IWVQYNDGSQLTVSPnRSSTITYTSSDGTVTRYNQSdslPEHVREK 69
 
Name Accession Description Interval E-value
DUF4524 pfam15025
Domain of unknown function (DUF4524); This family of proteins is found in eukaryotes. Proteins ...
 7-152 2.95e-78

Domain of unknown function (DUF4524); This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the N-terminal domain of the member proteins. The human gene is from C5orf34.


Pssm-ID: 464454  Cd Length: 146  Bit Score: 244.92  E-value: 2.95e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348408     7 MILYEDDSVQVQYVDGSTLQLSPCGSEFLFEKSPPVSAHPLEQPERIRQRTHFVISTYREQLQRALDFRNSSATCPFLSE 86
Cdd:pfam15025   1 MVLYEDDSVEVHFSDGSRLQLSPCGSEFLFEKADPPSAHPLQPGERVRQRTRFAISRYKPLLAAALEFRNQYAERPYLPE 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 38348408    87 TIIPSERKKHIFIDITEVRWPSLDTDGTMIYMESGIVKITSLDGHAYLCLPRSQHEFTVHFLCKVS 152
Cdd:pfam15025  81 EIIPSEKKKRLGSDISEAKWPSSSSSGLVTRGDGGSVTVSSEDGAAQLVLSPHQEEFTVEFLCKVS 146
DUF4520 pfam15016
Domain of unknown function (DUF4520); This family of proteins is found in eukaryotes. Proteins ...
 447-538 2.20e-41

Domain of unknown function (DUF4520); This family of proteins is found in eukaryotes. Proteins in this family are typically between 197 and 638 amino acids in length.This is the C-terminal domain of the member proteins.


Pssm-ID: 434393  Cd Length: 89  Bit Score: 144.79  E-value: 2.20e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 38348408   447 ILPLVLKESLIPSVGRFLAYSDDKVHAIFLDGITLTLNWNFSSpiEKRQVNqGLNLGWCKLTFPDGQEQLIQIEHPEPYE 526
Cdd:pfam15016   1 MSPVVLEESTIPGIGRFTAYSDGRVHVHFDDRTILTLVWDFSS--GKTQVN-RESTGWCKLLLPDGQQVLVRIEHPGHYE 77

                          90
                  ....*....|..
gi 38348408   527 RYVTTVTSWCRR 538
Cdd:pfam15016  78 RYVAAALEFCRW 89
POLO_box_Plk4_3 cd13116
C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak); The polo-like Ser ...
 15-56 7.01e-03

C-terminal (third) polo-box domain (PBD) of polo-like kinase 4 (Plk4/Sak); The polo-like Ser/Thr kinases (Plk1, Plk2/Snk, Plk3/Prk/Fnk, Plk4/Sak, and the inactive kinase Plk5) play various roles in cytokinesis and mitosis. At their C-terminus, they contain a tandemly repeated polo-box domain (in the case of Plk4, a tandem repeat of cryptic PBDs is found in the middle of the protein followed by a C-terminal single repeat), which appears to be involved in autoinhibition and in mediating the subcellular localization. The latter may be controlled via interactions between the polo-box domain and phospho-peptide motifs. The phosphopeptide binding site is formed at the interface between the two tandemly repeated PBDs. The PBDs of Plk4/Sak appear unique in participating in homodimer interactions, though it is not clear whether and how they interact with phosphopeptides.


Pssm-ID: 240559  Cd Length: 81  Bit Score: 36.03  E-value: 7.01e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*.
gi 38348408  15 VQVQYVDGSTLQLSP-CGSEFLFEKSPPVSAHPLEQ---PERIRQR 56
Cdd:cd13116  24 IWVQYNDGSQLTVSPnRSSTITYTSSDGTVTRYNQSdslPEHVREK 69
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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