NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|51371946|ref|NP_942601|]
View 

synovial sarcoma, X member B3 [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
KRAB super family cl42959
krueppel associated box;
23-78 8.69e-11

krueppel associated box;


The actual alignment was detected with superfamily member smart00349:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 54.52  E-value: 8.69e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 51371946     23 KAFQDISTYFSDEEWGKLTQWQKSAYM-YMKRNYIRMTDLGVTVNQPVFMRGKEQEK 78
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRdVMLENYSNLVSLGFQVPKPDLISQLEQGE 57
SSXRD pfam09514
SSXRD motif; SSX1 can repress transcription, and this has been attributed to a putative ...
137-160 3.87e-04

SSXRD motif; SSX1 can repress transcription, and this has been attributed to a putative Kruppel associated box (KRAB) repression domain at the N-terminus. However, from the analysis of these deletion constructs further repression activity was found at the C-terminus of SSX1. Which has been called the SSXRD (SSX Repression Domain). The potent repression exerted by full-length SSX1 appears to localize to this region.


:

Pssm-ID: 430657  Cd Length: 31  Bit Score: 36.21  E-value: 3.87e-04
                          10        20
                  ....*....|....*....|....
gi 51371946   137 GIQVNVWSHRLRERKYRViYSEIS 160
Cdd:pfam09514   3 RKEVEVWMYRLRERKGVV-YEEIS 25
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-78 8.69e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 54.52  E-value: 8.69e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 51371946     23 KAFQDISTYFSDEEWGKLTQWQKSAYM-YMKRNYIRMTDLGVTVNQPVFMRGKEQEK 78
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRdVMLENYSNLVSLGFQVPKPDLISQLEQGE 57
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
24-61 2.01e-07

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 45.23  E-value: 2.01e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 51371946  24 AFQDISTYFSDEEWGKLTQWQKSAYMYMKR-NYIRMTDL 61
Cdd:cd07765   2 TFEDVAVYFSQEEWELLDPAQRDLYRDVMLeNYENLVSL 40
SSXRD pfam09514
SSXRD motif; SSX1 can repress transcription, and this has been attributed to a putative ...
137-160 3.87e-04

SSXRD motif; SSX1 can repress transcription, and this has been attributed to a putative Kruppel associated box (KRAB) repression domain at the N-terminus. However, from the analysis of these deletion constructs further repression activity was found at the C-terminus of SSX1. Which has been called the SSXRD (SSX Repression Domain). The potent repression exerted by full-length SSX1 appears to localize to this region.


Pssm-ID: 430657  Cd Length: 31  Bit Score: 36.21  E-value: 3.87e-04
                          10        20
                  ....*....|....*....|....
gi 51371946   137 GIQVNVWSHRLRERKYRViYSEIS 160
Cdd:pfam09514   3 RKEVEVWMYRLRERKGVV-YEEIS 25
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
25-55 2.88e-03

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 33.98  E-value: 2.88e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 51371946    25 FQDISTYFSDEEWGKLTQWQKSAYM-YMKRNY 55
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRdVMLENY 35
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
23-78 8.69e-11

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 54.52  E-value: 8.69e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 51371946     23 KAFQDISTYFSDEEWGKLTQWQKSAYM-YMKRNYIRMTDLGVTVNQPVFMRGKEQEK 78
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRdVMLENYSNLVSLGFQVPKPDLISQLEQGE 57
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
24-61 2.01e-07

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 45.23  E-value: 2.01e-07
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 51371946  24 AFQDISTYFSDEEWGKLTQWQKSAYMYMKR-NYIRMTDL 61
Cdd:cd07765   2 TFEDVAVYFSQEEWELLDPAQRDLYRDVMLeNYENLVSL 40
SSXRD pfam09514
SSXRD motif; SSX1 can repress transcription, and this has been attributed to a putative ...
137-160 3.87e-04

SSXRD motif; SSX1 can repress transcription, and this has been attributed to a putative Kruppel associated box (KRAB) repression domain at the N-terminus. However, from the analysis of these deletion constructs further repression activity was found at the C-terminus of SSX1. Which has been called the SSXRD (SSX Repression Domain). The potent repression exerted by full-length SSX1 appears to localize to this region.


Pssm-ID: 430657  Cd Length: 31  Bit Score: 36.21  E-value: 3.87e-04
                          10        20
                  ....*....|....*....|....
gi 51371946   137 GIQVNVWSHRLRERKYRViYSEIS 160
Cdd:pfam09514   3 RKEVEVWMYRLRERKGVV-YEEIS 25
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
25-55 2.88e-03

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 33.98  E-value: 2.88e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 51371946    25 FQDISTYFSDEEWGKLTQWQKSAYM-YMKRNY 55
Cdd:pfam01352   4 FEDVAVDFTQEEWALLDPAQRNLYRdVMLENY 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH