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Conserved domains on  [gi|75677612|ref|NP_955372|]
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leucine-rich repeat-containing protein 37A3 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
1468-1590 2.86e-65

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


:

Pssm-ID: 434309  Cd Length: 147  Bit Score: 217.63  E-value: 2.86e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   1468 SPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWK 1547
Cdd:pfam14914    1 SPGDQFEIQLNQQLQSLIPNNDVRRLISHVIRTLKMDCSEPQVQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 75677612   1548 TENYINESTEAQSEQKE-KSLEFTKELPGYGYTKKLILALIVTG 1590
Cdd:pfam14914   81 NETYINESTEAQSKQKKqSSRELTKEVPGYGYNNKLILAISVTV 124
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
560-629 5.62e-22

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 90.89  E-value: 5.62e-22
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612    560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779    1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
892-949 5.38e-15

Leucine rich repeat;


:

Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 5.38e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 75677612    892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
251-319 1.36e-14

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 70.08  E-value: 1.36e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75677612    251 EEEPSSMQQEAPALPPESSMESL--TLPNHEVSVQPPGEDQAYY-HLPNITVKPADVEVTITSEPTNETESS 319
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVaqPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
332-429 1.91e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 63.92  E-value: 1.91e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612    332 EVEPSATQQEAPIEPPVPPmehelsiseqqqpvqpsessrevessptqQETPGQPPEHHEVTVSPPGHHQTHHLASPSVS 411
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESP-----------------------------KEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVT 51
                           90
                   ....*....|....*...
gi 75677612    412 VKPPDVQLTIAAEPSAEV 429
Cdd:pfam15779   52 VQPLDLELTITPEPTKEA 69
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
206-704 2.01e-12

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 72.43  E-value: 2.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263  344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263  422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   347 PVPPMEHELSISEQQ-----------QPV-QPSESSREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263  502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263  582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263  657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   556 -ESMTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263  737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677612   634 TIVSPKHPEVTLPHPDQVQTQhshltrATVQPLDLgfTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263  816 QYQQPQQPVAPQPQYQQPQQP------VAPQPQDT--LLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
689-739 1.11e-11

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


:

Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 61.61  E-value: 1.11e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 75677612    689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779   23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
866-1007 5.38e-03

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 41.11  E-value: 5.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612  866 TFTILNFQGNYIsYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEpLPFLKFINLS 945
Cdd:COG4886   94 PLPSLDLNLNRL-RSNISELLELTNLTSLDLDNNNITDIPPLIGLLKSNLKELDLSDNKIESLPSPLRN-LPNLKNLDLS 171
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 75677612  946 CNVITELSFGTFQAwhgmQFLHKLILNHNPLTTVEDPyLFKLPALKYLDMG-----TTLVPLTTLKN 1007
Cdd:COG4886  172 FNDLSDLPKLLSNL----SNLNNLDLSGNKISDLPPE-IELLSALEELDLSnnsiiELLSSLSNLKN 233
 
Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
1468-1590 2.86e-65

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


Pssm-ID: 434309  Cd Length: 147  Bit Score: 217.63  E-value: 2.86e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   1468 SPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWK 1547
Cdd:pfam14914    1 SPGDQFEIQLNQQLQSLIPNNDVRRLISHVIRTLKMDCSEPQVQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 75677612   1548 TENYINESTEAQSEQKE-KSLEFTKELPGYGYTKKLILALIVTG 1590
Cdd:pfam14914   81 NETYINESTEAQSKQKKqSSRELTKEVPGYGYNNKLILAISVTV 124
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
560-629 5.62e-22

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 90.89  E-value: 5.62e-22
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612    560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779    1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
892-949 5.38e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 5.38e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 75677612    892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
251-319 1.36e-14

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 70.08  E-value: 1.36e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75677612    251 EEEPSSMQQEAPALPPESSMESL--TLPNHEVSVQPPGEDQAYY-HLPNITVKPADVEVTITSEPTNETESS 319
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVaqPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
332-429 1.91e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 63.92  E-value: 1.91e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612    332 EVEPSATQQEAPIEPPVPPmehelsiseqqqpvqpsessrevessptqQETPGQPPEHHEVTVSPPGHHQTHHLASPSVS 411
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESP-----------------------------KEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVT 51
                           90
                   ....*....|....*...
gi 75677612    412 VKPPDVQLTIAAEPSAEV 429
Cdd:pfam15779   52 VQPLDLELTITPEPTKEA 69
PRK10263 PRK10263
DNA translocase FtsK; Provisional
206-704 2.01e-12

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 72.43  E-value: 2.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263  344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263  422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   347 PVPPMEHELSISEQQ-----------QPV-QPSESSREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263  502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263  582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263  657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   556 -ESMTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263  737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677612   634 TIVSPKHPEVTLPHPDQVQTQhshltrATVQPLDLgfTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263  816 QYQQPQQPVAPQPQYQQPQQP------VAPQPQDT--LLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
689-739 1.11e-11

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 61.61  E-value: 1.11e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 75677612    689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779   23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
508-565 7.70e-10

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 56.60  E-value: 7.70e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612    508 EGESSLTHQEAPAQTPEFPNVVVAQPP---------------EHSHLTQATVQPLDLGFTITPESMTEVELSP 565
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPvhhevtvptpgqgqaQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
874-978 9.38e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 9.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612  874 GNYISYIDGnvwkayswTEKLilreNNLTELH---------------KDSFEGLL-SLQYLDLSCNKIQSIErhTFEPLP 937
Cdd:cd21340   77 GNRISVVEG--------LENL----TNLEELHienqrlppgekltfdPRSLAALSnSLRVLNISGNNIDSLE--PLAPLR 142
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 75677612  938 FLKFINLSCNVITELS--FGTFQAWHgmqFLHKLILNHNPLTT 978
Cdd:cd21340  143 NLEQLDASNNQISDLEelLDLLSSWP---SLRELDLTGNPVCK 182
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
866-1007 5.38e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 41.11  E-value: 5.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612  866 TFTILNFQGNYIsYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEpLPFLKFINLS 945
Cdd:COG4886   94 PLPSLDLNLNRL-RSNISELLELTNLTSLDLDNNNITDIPPLIGLLKSNLKELDLSDNKIESLPSPLRN-LPNLKNLDLS 171
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 75677612  946 CNVITELSFGTFQAwhgmQFLHKLILNHNPLTTVEDPyLFKLPALKYLDMG-----TTLVPLTTLKN 1007
Cdd:COG4886  172 FNDLSDLPKLLSNL----SNLNNLDLSGNKISDLPPE-IELLSALEELDLSnnsiiELLSSLSNLKN 233
 
Name Accession Description Interval E-value
LRRC37AB_C pfam14914
LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of ...
1468-1590 2.86e-65

LRRC37A/B like protein 1 C-terminal domain; This family represents the C-terminal domain of the putative Leucine Rich Repeat Containing protein 37A or protein 37B (LRRC37A/B) found in eukaryotes. The Leucine Rich Repeats (LRR) lies in the central region. The gene that encodes this protein is found in the chromosomal position 17q11.2, and its microdeletion results in the disease, neurofibromatosis type-1 (NF1). The function of the protein, LRRC37B is unknown, however experimental data shows expression in the aorta, heart, skeletal muscle, liver and brain during gestation.


Pssm-ID: 434309  Cd Length: 147  Bit Score: 217.63  E-value: 2.86e-65
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   1468 SPGDQFEIQLTQQLQSVIPNNNVRRLIAHVIRTLKMDCSGAHVQVTCAKLVSRTGHLMKLLSGQQEVKASKIEWDTDQWK 1547
Cdd:pfam14914    1 SPGDQFEIQLNQQLQSLIPNNDVRRLISHVIRTLKMDCSEPQVQLACAKLISRTGLLMKLLSEQQEAKVSKADWDTDQWK 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 75677612   1548 TENYINESTEAQSEQKE-KSLEFTKELPGYGYTKKLILALIVTG 1590
Cdd:pfam14914   81 NETYINESTEAQSKQKKqSSRELTKEVPGYGYNNKLILAISVTV 124
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
560-629 5.62e-22

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 90.89  E-value: 5.62e-22
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612    560 EVELSPTMKETPTQP---PKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHST 629
Cdd:pfam15779    1 EVEPSPTQQETPTQPpesPKEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
892-949 5.38e-15

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 70.63  E-value: 5.38e-15
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 75677612    892 EKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVI 949
Cdd:pfam13855    4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
251-319 1.36e-14

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 70.08  E-value: 1.36e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75677612    251 EEEPSSMQQEAPALPPESSMESL--TLPNHEVSVQPPGEDQAYY-HLPNITVKPADVEVTITSEPTNETESS 319
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVaqPPVHHEVTVPTPGQGQAQHpTLPNVTVQPLDLELTITPEPTKEAEHS 72
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
332-429 1.91e-12

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 63.92  E-value: 1.91e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612    332 EVEPSATQQEAPIEPPVPPmehelsiseqqqpvqpsessrevessptqQETPGQPPEHHEVTVSPPGHHQTHHLASPSVS 411
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESP-----------------------------KEVVAQPPVHHEVTVPTPGQGQAQHPTLPNVT 51
                           90
                   ....*....|....*...
gi 75677612    412 VKPPDVQLTIAAEPSAEV 429
Cdd:pfam15779   52 VQPLDLELTITPEPTKEA 69
PRK10263 PRK10263
DNA translocase FtsK; Provisional
206-704 2.01e-12

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 72.43  E-value: 2.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   206 PPGPSEQVGPSQFHLE----PETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPssMQQEAPALPPESSMESLTLPNHEVS 281
Cdd:PRK10263  344 PPVASVDVPPAQPTVAwqpvPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEP--LQQPVQPQQPYYAPAAEQPAQQPYY 421
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   282 VQPPGEDQAYYHLPNITVKPA--------DVEVTITSEPTNETESSQAQ---QETPIQFPEEVEPSATQQEAP----IEP 346
Cdd:PRK10263  422 APAPEQPAQQPYYAPAPEQPVagnawqaeEQQSTFAPQSTYQTEQTYQQpaaQEPLYQQPQPVEQQPVVEPEPvveeTKP 501
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   347 PVPPMEHELSISEQQ-----------QPV-QPSESSREVESSPTQQETPGQPPEHHEVTVSP--PGHHQTHHLASPSVSV 412
Cdd:PRK10263  502 ARPPLYYFEEVEEKRarereqlaawyQPIpEPVKEPEPIKSSLKAPSVAAVPPVEAAAAVSPlaSGVKKATLATGAAATV 581
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   413 KPPDVQLTIAAEPSAEVGTSLVHQ-------EATTRLSGSGNDVEPPAIQhggppLLPESSEEAGPLAVQQETSFQSPEP 485
Cdd:PRK10263  582 AAPVFSLANSGGPRPQVKEGIGPQlprpkriRVPTRRELASYGIKLPSQR-----AAEEKAREAQRNQYDSGDQYNDDEI 656
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   486 INNENPSPTQQEAAAEHPQTAEEGESSLTHQ----EAPAQTPEFPNVVVAQPPEHSHLTQATVQPLDLG-FTITP----- 555
Cdd:PRK10263  657 DAMQQDELARQFAQTQQQRYGEQYQHDVPVNaedaDAAAEAELARQFAQTQQQRYSGEQPAGANPFSLDdFEFSPmkall 736
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   556 -ESMTEVELSPT-MKETPTQPPKKVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEpTTEVGHSTPPKR 633
Cdd:PRK10263  737 dDGPHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQ-YQQPQQPVAPQP 815
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677612   634 TIVSPKHPEVTLPHPDQVQTQhshltrATVQPLDLgfTITPKSMTEVEPSTALMTTAPPPGHPEVTLPPSD 704
Cdd:PRK10263  816 QYQQPQQPVAPQPQYQQPQQP------VAPQPQDT--LLHPLLMRNGDSRPLHKPTTPLPSLDLLTPPPSE 878
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
689-739 1.11e-11

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 61.61  E-value: 1.11e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 75677612    689 TAPPPGHPEVTLPPSDKGQAQHSHLTQATVQPLDLELTITTKPTTEVKPSP 739
Cdd:pfam15779   23 VAQPPVHHEVTVPTPGQGQAQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
LRR_8 pfam13855
Leucine rich repeat;
914-976 8.42e-11

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 58.69  E-value: 8.42e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612    914 SLQYLDLSCNKIQSIERHTFEPLPFLKFINLSCNVITELSFGTFqawHGMQFLHKLILNHNPL 976
Cdd:pfam13855    2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAF---SGLPSLRYLDLSGNRL 61
PHA03247 PHA03247
large tegument protein UL36; Provisional
190-752 1.94e-10

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 66.12  E-value: 1.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   190 PYPGSLPPELRVKS-------DEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPqlleeePSSMQQEAP 262
Cdd:PHA03247 2554 PLPPAAPPAAPDRSvppprpaPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLP------PDTHAPDPP 2627
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   263 alPPESSMESLTLPNHEVSVQPPGEDQAYYHLPNITVKPAdvEVTITSEPTNEteSSQAQQETPIQFPEEVEPSATQQEA 342
Cdd:PHA03247 2628 --PPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPR--RARRLGRAAQA--SSPPQRPRRRAARPTVGSLTSLADP 2701
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   343 PIEPPVPPMEHELSISEQQQPVQPSESSREVESSPTQQETPGQP-----PEHHEVTVSPPGHHQTHHLASPSVSVKPPDV 417
Cdd:PHA03247 2702 PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPagpatPGGPARPARPPTTAGPPAPAPPAAPAAGPPR 2781
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   418 QLTIAAEPSAevgtslvhQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPLAVQQetsfqSPEPINNENPSPTQQE 497
Cdd:PHA03247 2782 RLTRPAVASL--------SESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT-----SAQPTAPPPPPGPPPP 2848
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   498 AAAEHPQTAEEGESSlthQEAPAQTPefPNVVVAQP-PEHSHLTQATVQPLDLGFTITPESMTEvelsPTMKETPTQPPK 576
Cdd:PHA03247 2849 SLPLGGSVAPGGDVR---RRPPSRSP--AAKPAAPArPPVRRLARPAVSRSTESFALPPDQPER----PPQPQAPPPPQP 2919
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   577 KVVPQLRVYQGVTNPTPGQDQAQHPVSPSVTVQLLDLGLTITPEPTTEVGHSTPPKRTIVSPKHPEVTLPHPDQVQTQHS 656
Cdd:PHA03247 2920 QPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLTGH 2999
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   657 HLTRATVQPLDLGFTITPksmtevepstalmttAPPPGHPEVTL-PPSDKGQAQHSHLTQATVQPLDLEltiTTKPTTEV 735
Cdd:PHA03247 3000 SLSRVSSWASSLALHEET---------------DPPPVSLKQTLwPPDDTEDSDADSLFDSDSERSDLE---ALDPLPPE 3061
                         570
                  ....*....|....*..
gi 75677612   736 KPSPTTEETSTQLPDLG 752
Cdd:PHA03247 3062 PHDPFAHEPDPATPEAG 3078
LRRC37 pfam15779
Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, ...
508-565 7.70e-10

Leucine-rich repeat-containing protein 37 family; This domain family is found in eukaryotes, and is approximately 70 amino acids in length. The function of this protein is unknown but it is likely to be upregulated by androgen.


Pssm-ID: 434930 [Multi-domain]  Cd Length: 73  Bit Score: 56.60  E-value: 7.70e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 75677612    508 EGESSLTHQEAPAQTPEFPNVVVAQPP---------------EHSHLTQATVQPLDLGFTITPESMTEVELSP 565
Cdd:pfam15779    1 EVEPSPTQQETPTQPPESPKEVVAQPPvhhevtvptpgqgqaQHPTLPNVTVQPLDLELTITPEPTKEAEHST 73
PHA03247 PHA03247
large tegument protein UL36; Provisional
315-809 1.25e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.79  E-value: 1.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   315 ETESSQAQQETPIqFPEEVEPSATQQEAPIEPPVPPMEHELSISEQQQPVQPsessreveSSPTQQETPGQPPEhhevtv 394
Cdd:PHA03247 2542 ELASDDAGDPPPP-LPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAP--------PQSARPRAPVDDRG------ 2606
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   395 SPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTRLSGSGNDVEPP--------AIQHGGPPLLPesS 466
Cdd:PHA03247 2607 DPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPrrarrlgrAAQASSPPQRP--R 2684
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   467 EEAGPLAVQQETSFQSPEPINNE-NPSPTQQEAAAEHP---QTAEEGESSLTHQEAPAQTPEFPNV-----VVAQPPEHS 537
Cdd:PHA03247 2685 RRAARPTVGSLTSLADPPPPPPTpEPAPHALVSATPLPpgpAAARQASPALPAAPAPPAVPAGPATpggpaRPARPPTTA 2764
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   538 -----------------HLTQATVQPL-----DLGFTITPESMTEVELSPTMKETPTQPPKKVVPqlrvyqgvtnPTPGQ 595
Cdd:PHA03247 2765 gppapappaapaagpprRLTRPAVASLsesreSLPSPWDPADPPAAVLAPAAALPPAASPAGPLP----------PPTSA 2834
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   596 DQAQHPVSPSVTVQLLDLGLTITP-EPTTEVGHSTPPKRTIVSPKHPEVT-LPHPD-QVQTQHSHLTRATVQPLDLGFTI 672
Cdd:PHA03247 2835 QPTAPPPPPGPPPPSLPLGGSVAPgGDVRRRPPSRSPAAKPAAPARPPVRrLARPAvSRSTESFALPPDQPERPPQPQAP 2914
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   673 TPKSMTEVEPSTALMTTAP-PPGHPEVTLPPSDKGQA-----------QHSHLTQATVqPLDLELTITTKPTTEVKPSPT 740
Cdd:PHA03247 2915 PPPQPQPQPPPPPQPQPPPpPPPRPQPPLAPTTDPAGagepsgavpqpWLGALVPGRV-AVPRFRVPQPAPSREAPASST 2993
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 75677612   741 TEETSTQLPDLglaiipeptTETGHSTALEKTTAPRPDRV-QTLHrsltevtgPPTELEPA-QDSLVQSES 809
Cdd:PHA03247 2994 PPLTGHSLSRV---------SSWASSLALHEETDPPPVSLkQTLW--------PPDDTEDSdADSLFDSDS 3047
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
874-978 9.38e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 9.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612  874 GNYISYIDGnvwkayswTEKLilreNNLTELH---------------KDSFEGLL-SLQYLDLSCNKIQSIErhTFEPLP 937
Cdd:cd21340   77 GNRISVVEG--------LENL----TNLEELHienqrlppgekltfdPRSLAALSnSLRVLNISGNNIDSLE--PLAPLR 142
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 75677612  938 FLKFINLSCNVITELS--FGTFQAWHgmqFLHKLILNHNPLTT 978
Cdd:cd21340  143 NLEQLDASNNQISDLEelLDLLSSWP---SLRELDLTGNPVCK 182
rne PRK10811
ribonuclease E; Reviewed
299-538 3.18e-05

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 48.88  E-value: 3.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   299 VKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPMEHElsiseqqqpvqpsessrevesspT 378
Cdd:PRK10811  848 VRPQDVQVEEQREAEEVQVQPVVAEVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAE-----------------------P 904
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   379 QQETPGQPPEHHEVTVSPPGHHQTHHLASPSVSVKPPDVQLTIAAEPSAEVGTSLVHQEATTrlsgsgndveppaiqhgg 458
Cdd:PRK10811  905 QPEEVVVVETTHPEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETA------------------ 966
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   459 PPLLPESSEEAGPLAVQQETsfqSPEPINNENPSPTQQEAAAEHPQTAEEGESSLTHQEAPAqtPEFpnvvVAQPPEHSH 538
Cdd:PRK10811  967 EVVVAEPEVVAQPAAPVVAE---VAAEVETVTAVEPEVAPAQVPEATVEHNHATAPMTRAPA--PEY----VPEAPRHSD 1037
rne PRK10811
ribonuclease E; Reviewed
223-593 1.08e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 46.96  E-value: 1.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   223 ETQNPETLEDIQSSSLQQEAPAQLPQ-LLEEEPSSMQQEAPALPPEssmesltlpnHEVSVQPPGEDQAYYHLPNITVKP 301
Cdd:PRK10811  655 ESQQAEVTEKARTQDEQQQAPRRERQrRRNDEKRQAQQEAKALNVE----------EQSVQETEQEERVQQVQPRRKQRQ 724
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   302 ADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPPmehELSISEQQQPVQpsessrevesspTQQE 381
Cdd:PRK10811  725 LNQKVRIEQSVAEEAVAPVVEETVAAEPVVQEVPAPRTELVKVPLPVVA---QTAPEQDEENNA------------ENRD 789
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   382 TPGQP------PEHHEV--------------TVSP-PghhQTHHLASPSVS----------VKPPDVQLTIAAEPSAEVG 430
Cdd:PRK10811  790 NNGMPrrsrrsPRHLRVsgqrrrryrderypTQSPmP---LTVACASPEMAsgkvwirypvVRPQDVQVEEQREAEEVQV 866
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   431 TSLVHqEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGPlAVQQETSFQSPEPIN---NENPSPTQQEAAAEHPQTAE 507
Cdd:PRK10811  867 QPVVA-EVPVAAAVEPVVSAPVVEAVAEVVEEPVVVAEPQP-EEVVVVETTHPEVIAapvTEQPQVITESDVAVAQEVAE 944
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   508 EGESSLTHQEAPAQTPEFPNVVVAQPPEHSHLTQATVQPldlgfTITPESMTEVELSPTMKETPTQPPKKVVPQLRVYQG 587
Cdd:PRK10811  945 HAEPVVEPQDETADIEEAAETAEVVVAEPEVVAQPAAPV-----VAEVAAEVETVTAVEPEVAPAQVPEATVEHNHATAP 1019

                  ....*..
gi 75677612   588 VTN-PTP 593
Cdd:PRK10811 1020 MTRaPAP 1026
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
49-383 1.31e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteristic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 427171 [Multi-domain]  Cd Length: 991  Bit Score: 46.68  E-value: 1.31e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612     49 LTSNPLGPPEPWSSHSSHfPRESPHAPtLPADPWDFdHLGPSaSSEMPAPPQestenlvPFLDTWDSA-GELPLEPEQFL 127
Cdd:pfam03154  249 LQPMTQPPPPSQVSPQPL-PQPSLHGQ-MPPMPHSL-QTGPS-HMQHPVPPQ-------PFPLTPQSSqSQVPPGPSPAA 317
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612    128 ASQQDLKDKLSPQERLPVSPKKLKKDPAQRWSLA------EIIGIIHQLSTPQSQKQtlqneysstdtPYPGSLPPELRV 201
Cdd:pfam03154  318 PGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLSmphikpPPTTPIPQLPNPQSHKH-----------PPHLSGPSPFQM 386
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612    202 KSDEPPGPSEQVGPSQFHLEPETQNPETLEDIQSSSLQQEAPAQLPQLleeepssmqQEAPALPPESSMESLTLPNHEVS 281
Cdd:pfam03154  387 NSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQQLPPPPAQPPVL---------TQSQSLPPPAASHPPTSGLHQVP 457
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612    282 VQPPGEDQAYYHLPNITVKPAdvevtitSEPTNETESSQaqqeTPIQFPEEVEPSATQQ-EAPIEPPVPPME-HELSISE 359
Cdd:pfam03154  458 SQSPFPQHPFVPGGPPPITPP-------SGPPTSTSSAM----PGIQPPSSASVSSSGPvPAAVSCPLPPVQiKEEALDE 526
                          330       340
                   ....*....|....*....|....
gi 75677612    360 QQQPVQPSESSREVESSPTQQETP 383
Cdd:pfam03154  527 AEEPESPPPPPRSPSPEPTVVNTP 550
rne PRK10811
ribonuclease E; Reviewed
215-418 2.30e-04

ribonuclease E; Reviewed


Pssm-ID: 236766 [Multi-domain]  Cd Length: 1068  Bit Score: 46.19  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   215 PSQFHLEPETQNPETLEDIQSSSLQQEAPAQlpqllEEEPSSMQQEAPALPPEssmesltlPNHEVSVQPPGEDQAYYHL 294
Cdd:PRK10811  850 PQDVQVEEQREAEEVQVQPVVAEVPVAAAVE-----PVVSAPVVEAVAEVVEE--------PVVVAEPQPEEVVVVETTH 916
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   295 PNITVKPADVEVTITSEPTNETESSQAQQETPIQFPEEVEPSATQQEAPIEPPVPpmehelsisEQQQPVQPSESSREVE 374
Cdd:PRK10811  917 PEVIAAPVTEQPQVITESDVAVAQEVAEHAEPVVEPQDETADIEEAAETAEVVVA---------EPEVVAQPAAPVVAEV 987
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 75677612   375 SSPTQQETPGQPPEHHEVTVSPPGHHqtHHLASPSVSVKPPDVQ 418
Cdd:PRK10811  988 AAEVETVTAVEPEVAPAQVPEATVEH--NHATAPMTRAPAPEYV 1029
PHA03247 PHA03247
large tegument protein UL36; Provisional
39-418 3.57e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 45.70  E-value: 3.57e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612    39 PLEWVKDPLQLTSNPLGPPEPWSSHSSHFP---RESPHAPTLPADPwdfdhlGPSASSEMPAPPQESTENLVPFLDTWDS 115
Cdd:PHA03247 2694 SLTSLADPPPPPPTPEPAPHALVSATPLPPgpaAARQASPALPAAP------APPAVPAGPATPGGPARPARPPTTAGPP 2767
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   116 AGELPLEPEQFLASQQDLKDKLSPQERLPVSPkkLKKDPAQrwSLAEIIGIIHQLSTPQSQKQTLQNEYSSTDT------ 189
Cdd:PHA03247 2768 APAPPAAPAAGPPRRLTRPAVASLSESRESLP--SPWDPAD--PPAAVLAPAAALPPAASPAGPLPPPTSAQPTappppp 2843
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   190 -PYPGSLPPELRVKsdePPGPSEQVGPSQfhlePETQNPETLEDIQSSSLQQEAPAQLPQLLEEEPSSMQQEAPALPPES 268
Cdd:PHA03247 2844 gPPPPSLPLGGSVA---PGGDVRRRPPSR----SPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPP 2916
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   269 SMESLTLPNHEvSVQPPGEDQAyyhLPNITVKPaDVEVTITSEPTNETESSQAQQETPIQFP---EEVEPSATQQEAPIE 345
Cdd:PHA03247 2917 PQPQPQPPPPP-QPQPPPPPPP---RPQPPLAP-TTDPAGAGEPSGAVPQPWLGALVPGRVAvprFRVPQPAPSREAPAS 2991
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   346 PPVPPMEHEL--------SISEQQQPVQPSESSREVESSPTQQE--------------------TPGQPPEHHEVTVSP- 396
Cdd:PHA03247 2992 STPPLTGHSLsrvsswasSLALHEETDPPPVSLKQTLWPPDDTEdsdadslfdsdsersdlealDPLPPEPHDPFAHEPd 3071
                         410       420
                  ....*....|....*....|..
gi 75677612   397 PGHHQTHHLASPSVSVKPPDVQ 418
Cdd:PHA03247 3072 PATPEAGARESPSSQFGPPPLS 3093
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
914-954 1.21e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 432794 [Multi-domain]  Cd Length: 44  Bit Score: 37.99  E-value: 1.21e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 75677612    914 SLQYLDLSCNKIQSIErhTFEPLPFLKFINLS-CNVITELSF 954
Cdd:pfam12799    2 NLEVLDLSNNQITDLP--PLAKLPNLETLDLSgNNKITDLSD 41
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
892-929 2.14e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 432794 [Multi-domain]  Cd Length: 44  Bit Score: 37.22  E-value: 2.14e-03
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 75677612    892 EKLILRENNLTELhkDSFEGLLSLQYLDLS-CNKIQSIE 929
Cdd:pfam12799    4 EVLDLSNNQITDL--PPLAKLPNLETLDLSgNNKITDLS 40
PRK14949 PRK14949
DNA polymerase III subunits gamma and tau; Provisional
197-602 3.53e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237863 [Multi-domain]  Cd Length: 944  Bit Score: 42.02  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   197 PELRVKSDEPPGPSEQVGPSQFHLEP-ETQNPETLEDIQSSSLQqeAPAQLPQLLEEEPSSMQQEAPALPPESSMESLTL 275
Cdd:PRK14949  359 PEKPVKRWQVDDPAEISLPEGQTPSAlAAAVQAPHANEPQFVNA--APAEKKTALTEQTTAQQQVQAANAEAVAEADASA 436
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   276 PNHEVSVQPPGED--------------------QAYYHLPNITVKP-ADVEVTITSEPTNETESS------QAQQETPIQ 328
Cdd:PRK14949  437 EPADTVEQALDDEsellaalnaeqavilsqaqsQGFEASSSLDADNsAVPEQIDSTAEQSVVNPSvtdtqvDDTSASNNS 516
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   329 FPEEVEPSATQQEAPIEPpvppmeHELSISEQQQPVQPSESSREVESSPTQQETPGQPPEHHEVTVSPPGHHQthHLASP 408
Cdd:PRK14949  517 AADNTVDDNYSAEDTLES------NGLDEGDYAQDSAPLDAYQDDYVAFSSESYNALSDDEQHSANVQSAQSA--AEAQP 588
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   409 SVSVKPPDVQLTIAAEPSAE-----------------VGTSLVHQEATTRLSGSGNDVEPPAIQHGGPPLLPESSEEAGP 471
Cdd:PRK14949  589 SSQSLSPISAVTTAAASLADddildavlaardsllsdLDALSPKEGDGKKSSADRKPKTPPSRAPPASLSKPASSPDASQ 668
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   472 LAVQQETSFQS-PEPINNENPSPTQ-QEAAAEHPQT----------AEEGESSLTHQEAPAQTPEFPNVV---------V 530
Cdd:PRK14949  669 TSASFDLDPDFeLATHQSVPEAALAsGSAPAPPPVPdpydrppweeAPEVASANDGPNNAAEGNLSESVEdasnselqaV 748
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 75677612   531 AQPPEHSHLTQATVQPldlgftitpesmtevelsPTMKETPTQPPKKVVPQlrvyQGVTNPTPGQDQAQHPV 602
Cdd:PRK14949  749 EQQATHQPQVQAEAQS------------------PASTTALTQTSSEVQDT----ELNLVLLSSGSITGHPL 798
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
891-976 5.13e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 40.80  E-value: 5.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612  891 TEKLILRENNLTELH-KDSFEGL---LSLQYLDLSCNKIQSIER------HTFEPLPFLKFINLSCNVITELSFGTFQAW 960
Cdd:cd00116   25 LQVLRLEGNTLGEEAaKALASALrpqPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGVLESL 104
                         90
                 ....*....|....*.
gi 75677612  961 HGMQFLHKLILNHNPL 976
Cdd:cd00116  105 LRSSSLQELKLNNNGL 120
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
866-1007 5.38e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 227223 [Multi-domain]  Cd Length: 394  Bit Score: 41.11  E-value: 5.38e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612  866 TFTILNFQGNYIsYIDGNVWKAYSWTEKLILRENNLTELHKDSFEGLLSLQYLDLSCNKIQSIERHTFEpLPFLKFINLS 945
Cdd:COG4886   94 PLPSLDLNLNRL-RSNISELLELTNLTSLDLDNNNITDIPPLIGLLKSNLKELDLSDNKIESLPSPLRN-LPNLKNLDLS 171
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 75677612  946 CNVITELSFGTFQAwhgmQFLHKLILNHNPLTTVEDPyLFKLPALKYLDMG-----TTLVPLTTLKN 1007
Cdd:COG4886  172 FNDLSDLPKLLSNL----SNLNNLDLSGNKISDLPPE-IELLSALEELDLSnnsiiELLSSLSNLKN 233
PRK10263 PRK10263
DNA translocase FtsK; Provisional
438-785 7.08e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.22  E-value: 7.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   438 ATTRLSGSGNDVEPpaIQHGGPPLLPESSEEAGPLAVQQETSFQSPEPINNENPsptqqEAAAEHPQTAEEGESSLTHQE 517
Cdd:PRK10263  326 ATTATQSWAAPVEP--VTQTPPVASVDVPPAQPTVAWQPVPGPQTGEPVIAPAP-----EGYPQQSQYAQPAVQYNEPLQ 398
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   518 APAQTPEFPNVVVAQPPEHSHLTQATVQPLDLGFTITPESMTEVELSPTMKEtPTQPPKKVVPQLRVYQGVTNPTPG--Q 595
Cdd:PRK10263  399 QPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAE-EQQSTFAPQSTYQTEQTYQQPAAQepL 477
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   596 DQAQHPVSPSVTVQlldlgltitPEPTTEvghSTPPKRTivspkhPEVTLPHPDQVQTQHSHLTRATVQPLdlgftitPK 675
Cdd:PRK10263  478 YQQPQPVEQQPVVE---------PEPVVE---ETKPARP------PLYYFEEVEEKRAREREQLAAWYQPI-------PE 532
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 75677612   676 SMTEVEPSTALMTTAPPPGHPEVTlppsdkgqaqhshlTQATVQPLDLELTITTkpttevkpSPTTEETSTQLPDLGLAI 755
Cdd:PRK10263  533 PVKEPEPIKSSLKAPSVAAVPPVE--------------AAAAVSPLASGVKKAT--------LATGAAATVAAPVFSLAN 590
                         330       340       350
                  ....*....|....*....|....*....|..
gi 75677612   756 --IPEPTTETGHSTALekttaPRPDRVQTLHR 785
Cdd:PRK10263  591 sgGPRPQVKEGIGPQL-----PRPKRIRVPTR 617
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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