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Conserved domains on  [gi|254675251|ref|NP_958792|]
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plectin isoform 1d [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CH_PLEC-like_rpt1 cd21188
first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family; This family ...
9-113 7.17e-76

first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family; This family includes plectin, dystonin and microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1). Plectin, also called PCN, PLTN, hemidesmosomal protein 1 (HD1), or plectin-1, is a structural component of muscle. It interlinks intermediate filaments with microtubules and microfilaments, and anchors intermediate filaments to desmosomes or hemidesmosomes. It could also bind muscle proteins such as actin to membrane complexes in muscle. Dystonin, also called 230 kDa bullous pemphigoid antigen, 230/240 kDa bullous pemphigoid antigen, bullous pemphigoid antigen 1 (BPA or BPAG1), dystonia musculorum protein, or hemidesmosomal plaque protein, is a cytoskeletal linker protein that acts as an integrator of intermediate filaments, actin, and microtubule cytoskeleton networks. It is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells, or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. MACF1, also called 620 kDa actin-binding protein (ABP620), actin cross-linking family protein 7 (ACF7), macrophin-1, or trabeculin-alpha, is a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. It facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Members of this family contain two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409037  Cd Length: 105  Bit Score: 247.31  E-value: 7.17e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    9 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNI 88
Cdd:cd21188     1 DAVQKKTFTKWVNKHLIKARRRVVDLFEDLRDGHNLISLLEVLSGESLPRERGRMRFHRLQNVQTALDFLKYRKIKLVNI 80
                          90       100
                  ....*....|....*....|....*
gi 254675251   89 RNDDIADGNPKLTLGLIWTIILHFQ 113
Cdd:cd21188    81 RAEDIVDGNPKLTLGLIWTIILHFQ 105
CH_PLEC_rpt2 cd21238
second calponin homology (CH) domain found in plectin and similar proteins; Plectin, also ...
126-231 8.68e-72

second calponin homology (CH) domain found in plectin and similar proteins; Plectin, also called PCN, PLTN, hemidesmosomal protein 1 (HD1), or plectin-1, is a structural component of muscle. It interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. It can also bind muscle proteins such as actin to membrane complexes in muscle. Plectin contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


:

Pssm-ID: 409087  Cd Length: 106  Bit Score: 236.07  E-value: 8.68e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  126 MTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 205
Cdd:cd21238     1 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 80
                          90       100
                  ....*....|....*....|....*.
gi 254675251  206 PEDVDVPQPDEKSIITYVSSLYDAMP 231
Cdd:cd21238    81 PEDVDVPQPDEKSIITYVSSLYDAMP 106
PTZ00121 super family cl31754
MAEBL; Provisional
1311-2016 2.52e-36

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 153.37  E-value: 2.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1311 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSiqEELQHL 1390
Cdd:PTZ00121 1101 EEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKA--EDAKKA 1178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1391 RQSSEAEIQAKAQQVEAAERSRmRIEEEIRVVRLQlETTERQRGGAEGELQALRaRAEEAeaqkRQAQEEAERLRRQVQD 1470
Cdd:PTZ00121 1179 EAARKAEEVRKAEELRKAEDAR-KAEAARKAEEER-KAEEARKAEDAKKAEAVK-KAEEA----KKDAEEAKKAEEERNN 1251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1471 ESQRKRQAEAELALRVKAEAEAAREKQRAlqalDELRlQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASF 1550
Cdd:PTZ00121 1252 EEIRKFEEARMAHFARRQAAIKAEEARKA----DELK-KAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEE 1326
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1551 AEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRlqAEEVaqqkslAQADAEKQ 1630
Cdd:PTZ00121 1327 AKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKK--AEEK------KKADEAKK 1398
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1631 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATA 1710
Cdd:PTZ00121 1399 KAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKK 1478
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1711 ATQKRQeleAELAKVRAEmevllASKARAEEESRSTSEKSKqrleAEAGRFRELAEEAARLRAlAEEAKRQRQLAEEDAA 1790
Cdd:PTZ00121 1479 AEEAKK---ADEAKKKAE-----EAKKKADEAKKAAEAKKK----ADEAKKAEEAKKADEAKK-AEEAKKADEAKKAEEK 1545
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1791 RQRAEAERvlTEKLAAISEatrlKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKASESE 1870
Cdd:PTZ00121 1546 KKADELKK--AEELKKAEE----KKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAK 1619
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1871 L--------ERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDtMRSKEQAELEAARQRQLAA 1942
Cdd:PTZ00121 1620 IkaeelkkaEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEE-AKKAEEDEKKAAEALKKEA 1698
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251 1943 EEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2016
Cdd:PTZ00121 1699 EEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEE 1772
PTZ00121 super family cl31754
MAEBL; Provisional
1687-2534 3.20e-29

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 129.88  E-value: 3.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1687 TEQGEQQRQLLEEELARLQHEATAATqkRQELEAELAKVR------AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1760
Cdd:PTZ00121 1033 TEYGNNDDVLKEKDIIDEDIDGNHEG--KAEAKAHVGQDEglkpsyKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGK 1110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1761 FRElAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEdeaf 1840
Cdd:PTZ00121 1111 AEE-ARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAE---- 1185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1841 QRRRLEEqaaLHKADIEERLAQLRKASEselerqkglvEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNA 1920
Cdd:PTZ00121 1186 EVRKAEE---LRKAEDARKAEAARKAEE----------ERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNE 1252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1921 EdtMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKValEEVERLKAKVEEARRLRERAEQesarq 2000
Cdd:PTZ00121 1253 E--IRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEK--KKADEAKKKAEEAKKADEAKKK----- 1323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2001 lqlAQEAAQKRLQAEEKAhafvvqqreeelqqtlqqeqnmldrlrseaeaarraaeeaeeareqaereaaQSRKQVEEAE 2080
Cdd:PTZ00121 1324 ---AEEAKKKADAAKKKA----------------------------------------------------EEAKKAAEAA 1348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2081 RLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQtLRQKAQVEQELTTLRLQL 2160
Cdd:PTZ00121 1349 KAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADE-LKKAAAAKKKADEAKKKA 1427
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2161 EETDHQksildEELQRLKAEVTEAARQRSQVEEelfsvRVQMEELGKlkaRIEAENRALILRDKDNTQRFLEE---EAEK 2237
Cdd:PTZ00121 1428 EEKKKA-----DEAKKKAEEAKKADEAKKKAEE-----AKKAEEAKK---KAEEAKKADEAKKKAEEAKKADEakkKAEE 1494
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2238 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK----EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2313
Cdd:PTZ00121 1495 AKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKadeaKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEE 1574
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2314 DKeQMAQQLVEETQgfqrtlEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKqAEEIGEKLHRTELATQEKV 2393
Cdd:PTZ00121 1575 DK-NMALRKAEEAK------KAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKK-AEEEKKKVEQLKKKEAEEK 1646
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2394 TLVQTL-------EIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQ-----EQILQETQALQKSFL 2461
Cdd:PTZ00121 1647 KKAEELkkaeeenKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEElkkkeAEEKKKAEELKKAEE 1726
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251 2462 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRK 2534
Cdd:PTZ00121 1727 ENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKK 1799
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
859-936 5.92e-29

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


:

Pssm-ID: 436447  Cd Length: 78  Bit Score: 112.30  E-value: 5.92e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251   859 LAWQSLSRDIQLIRSWSLVTFRTLKPEEQRQALRNLELHYQAFLRDSQDAGGFGPEDRLVAEREYGSCSRHYQQLLQS 936
Cdd:pfam18373    1 VSWQYLLKDIERIRSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNACQQHYQTLLVS 78
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
758-824 7.16e-22

SH3 domain; This entry represents an SH3 domain.


:

Pssm-ID: 407754  Cd Length: 65  Bit Score: 91.55  E-value: 7.16e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251   758 QLKPRNpaHPVRGHVPLIAVCDYKQVEVTVHKGDQCQLVGPAQPSHWKVLSGSSSEAAVPSVCFLVP 824
Cdd:pfam17902    1 PLKQRR--SPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
SbcC super family cl33865
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
991-1527 7.80e-18

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


The actual alignment was detected with superfamily member COG0419:

Pssm-ID: 223496 [Multi-domain]  Cd Length: 908  Bit Score: 91.75  E-value: 7.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  991 QQKAQAEVEGLGKGVARLSAEAEKVLALPE-----PSPAAPTLRSELELTLGKLEQVRSLSA-IYLEKLKTISLVIRSTQ 1064
Cdd:COG0419   191 EGQLSELLEDIEDLLEALEEELKELKKLEEiqeeqEEEELEQEIEALEERLAELEEEKERLEeLKARLLEIESLELEALK 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1065 GAEEVLKTHEEQLKEAQAVPATLQELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRE 1144
Cdd:COG0419   271 IREEELRELERLLEELEEKIERLEELEREIEELEEELEGLRALLEELEELLEKLKSLEERLEKLEEKLEKLESELEELAE 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1145 RVTQLLERWQAvlaqtdvRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAVPIANCQAAREQLRQEKALLEEIE 1224
Cdd:COG0419   351 EKNELAKLLEE-------RLKELEERLEELEKELEKALERLKQLEEAIQELKEELAELSAALEEIQEELEELEKELEELE 423
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1225 RHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEP-------------VASPAKKPKVQSGSESVIQEYVDLRTRYSEL 1291
Cdd:COG0419   424 RELEELEEEIKKLEEQINQLESKELMIAELAGAGEKcpvcgqelpeeheKELLELYELELEELEEELSREKEEAELREEI 503
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1292 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLaeahaqAKAQAELEAQELQRRMQEEVARREE 1371
Cdd:COG0419   504 EELEKELRELEEELIELLELEEALKEELEEKLEKLENLLEELEELKEKL------QLQQLKEELRQLEDRLQELKELLEE 577
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1372 AAvdaqqQKRSIQEELQHLRQSSEaeiQAKAQQVEAAERSRmRIEEEIRvvRLQLETTERQRGGAEGELQALRARAEEA- 1450
Cdd:COG0419   578 LR-----LLRTRKEELEELRERLK---ELKKKLKELEERLS-QLEELLQ--SLELSEAENELEEAEEELESELEKLNLQa 646
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1451 --EAQKRQAQEEAERLRRQVQDESQRKRQ---AEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERA 1525
Cdd:COG0419   647 elEELLQAALEELEEKVEELEAEIRRELQrieNEEQLEEKLEELEQLEEELEQLREELEELLKKLGEIEQLIEELESRKA 726

                  ..
gi 254675251 1526 RQ 1527
Cdd:COG0419   727 EL 728
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3428-3466 1.42e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 72.76  E-value: 1.42e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3428 LLEAQVATGGIIDPVHSHRLPVDVAYQRGYFDEEMNRVL 3466
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4006-4044 2.58e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 72.37  E-value: 2.58e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  4006 LLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEIL 4044
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
2769-2807 5.21e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 71.22  E-value: 5.21e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  2769 LLEAQIATGGIIDPVHSHRVPVDVAYKRGYFDEEMNRIL 2807
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3687-3725 7.55e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 70.83  E-value: 7.55e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3687 LLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3725
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
583-761 2.70e-14

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


:

Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 74.79  E-value: 2.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  583 LHGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESYSALMRELEMKEKKIKEIQNTGDRLLREDHPARPTVESFQ 662
Cdd:cd00176     2 LQQFLRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  663 AALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLQKLQETLRRKYSCDrtiTVTRLEDLLQDAQDEKEQLNEY 742
Cdd:cd00176    82 EELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGK---DLESVEELLKKHKELEEELEAH 158
                         170
                  ....*....|....*....
gi 254675251  743 KGHLSGLAKRAKAIVQLKP 761
Cdd:cd00176   159 EPRLKSLNELAEELLEEGH 177
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3021-3059 2.04e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 66.98  E-value: 2.04e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3021 LLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPELHEKL 3059
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4275-4313 8.66e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 65.05  E-value: 8.66e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  4275 LLEAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMVDRI 4313
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3352-3390 2.53e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 63.51  E-value: 2.53e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3352 LLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKL 3390
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3097-3135 3.02e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 63.51  E-value: 3.02e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3097 LLDAQLSTGGIVDPSKSHRVPLDVAYARGYLDKETNRAL 3135
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
2693-2731 4.64e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 63.13  E-value: 4.64e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  2693 LLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKL 2731
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3930-3968 5.99e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 62.74  E-value: 5.99e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3930 LLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKL 3968
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3763-3801 6.67e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 62.36  E-value: 6.67e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3763 LLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3801
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4351-4389 6.43e-11

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 59.66  E-value: 6.43e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  4351 FLEVQYLTGGLIEPDTPGRVSLDEALQRGTVDARTAQKL 4389
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4107-4135 5.27e-07

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 48.49  E-value: 5.27e-07
                           10        20
                   ....*....|....*....|....*....
gi 254675251  4107 IVDPETGKEMSVYEAYRKGLIDHQTYLEL 4135
Cdd:pfam00681   11 IIDPVTGERLSVEEALKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
3890-3927 2.37e-06

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.71  E-value: 2.37e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 254675251   3890 QKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTA 3927
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
3058-3094 1.81e-05

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.40  E-value: 1.81e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3058 KLLSAEKAVTGYRDPYSGQSVSLFQALKKGLIPREQG 3094
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3314-3352 2.02e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 44.25  E-value: 2.02e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3314 LLQGSGCLAGIYLEDSKEKVTIYEAMRRGLLRPSTATLL 3352
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
2655-2693 3.57e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


:

Pssm-ID: 425816  Cd Length: 39  Bit Score: 43.48  E-value: 3.57e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  2655 YLKGRSSIAGLLLKPTNEKLSVYTALQRQLLSPGTALIL 2693
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
3648-3684 1.04e-04

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 42.08  E-value: 1.04e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3648 RYLYGTGAVAGVYLPGSRQTLTIYQALKKGLLSAEVA 3684
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
3724-3760 1.60e-04

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.70  E-value: 1.60e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3724 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPAEEA 3760
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
4239-4272 1.82e-04

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.31  E-value: 1.82e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 254675251   4239 EETGPVAGILDTETLEKVSITEAMHRNLVDNITG 4272
Cdd:smart00250    5 EAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2981-3018 5.15e-04

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.16  E-value: 5.15e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 254675251   2981 RQALRGTNVIAGVWLEEAGQKLSIYEALKKDLLQPEVA 3018
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2730-2766 2.06e-03

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 38.62  E-value: 2.06e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   2730 KLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVRDHG 2766
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
SPEC smart00150
Spectrin repeats;
487-581 2.88e-03

Spectrin repeats;


:

Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 40.01  E-value: 2.88e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    487 LRYLQDLLAWVEENQRRIDSAEWGVDLPSVEAQLGSHRGMHQSIEEFRAKIERARNDESQL---SPATRGAYRDCLGRLD 563
Cdd:smart00150    4 LRDADELEAWLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLieeGHPDAEEIEERLEELN 83
                            90
                    ....*....|....*...
gi 254675251    564 LQYAKLLNSSKARLRSLE 581
Cdd:smart00150   84 ERWEELKELAEERRQKLE 101
PLEC smart00250
Plectin repeat;
3389-3420 4.95e-03

Plectin repeat;


:

Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.46  E-value: 4.95e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 254675251   3389 KLLSAEKAVTGYKDPYSGNTISLFQAMKKGLV 3420
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLI 33
 
Name Accession Description Interval E-value
CH_PLEC-like_rpt1 cd21188
first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family; This family ...
9-113 7.17e-76

first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family; This family includes plectin, dystonin and microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1). Plectin, also called PCN, PLTN, hemidesmosomal protein 1 (HD1), or plectin-1, is a structural component of muscle. It interlinks intermediate filaments with microtubules and microfilaments, and anchors intermediate filaments to desmosomes or hemidesmosomes. It could also bind muscle proteins such as actin to membrane complexes in muscle. Dystonin, also called 230 kDa bullous pemphigoid antigen, 230/240 kDa bullous pemphigoid antigen, bullous pemphigoid antigen 1 (BPA or BPAG1), dystonia musculorum protein, or hemidesmosomal plaque protein, is a cytoskeletal linker protein that acts as an integrator of intermediate filaments, actin, and microtubule cytoskeleton networks. It is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells, or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. MACF1, also called 620 kDa actin-binding protein (ABP620), actin cross-linking family protein 7 (ACF7), macrophin-1, or trabeculin-alpha, is a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. It facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Members of this family contain two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409037  Cd Length: 105  Bit Score: 247.31  E-value: 7.17e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    9 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNI 88
Cdd:cd21188     1 DAVQKKTFTKWVNKHLIKARRRVVDLFEDLRDGHNLISLLEVLSGESLPRERGRMRFHRLQNVQTALDFLKYRKIKLVNI 80
                          90       100
                  ....*....|....*....|....*
gi 254675251   89 RNDDIADGNPKLTLGLIWTIILHFQ 113
Cdd:cd21188    81 RAEDIVDGNPKLTLGLIWTIILHFQ 105
CH_PLEC_rpt2 cd21238
second calponin homology (CH) domain found in plectin and similar proteins; Plectin, also ...
126-231 8.68e-72

second calponin homology (CH) domain found in plectin and similar proteins; Plectin, also called PCN, PLTN, hemidesmosomal protein 1 (HD1), or plectin-1, is a structural component of muscle. It interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. It can also bind muscle proteins such as actin to membrane complexes in muscle. Plectin contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409087  Cd Length: 106  Bit Score: 236.07  E-value: 8.68e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  126 MTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 205
Cdd:cd21238     1 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 80
                          90       100
                  ....*....|....*....|....*.
gi 254675251  206 PEDVDVPQPDEKSIITYVSSLYDAMP 231
Cdd:cd21238    81 PEDVDVPQPDEKSIITYVSSLYDAMP 106
SAC6 COG5069
Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton];
10-338 3.44e-45

Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton];


Pssm-ID: 227401 [Multi-domain]  Cd Length: 612  Bit Score: 175.90  E-value: 3.44e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   10 RVQKKTFTKWVNKHLIKA-QRHISDLYEDLRDGHNLISLLEVLSGDSLPR--EKGRMRFHKLQNVQIALDYLRHRQVKLV 86
Cdd:COG5069     8 KVQKKTFTKWTNEKLISGgQKEFGDLDTDLKDGVKLAQLLEALQKDNAGEynETPETRIHVMENVSGRLEFIKGKGVKLF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   87 NIRNDDIADGNPKLTLGLIWTIILHFQISDIQvsgQSEDMTAKEKLLLWSQRMVEGYQ-GLRCDNFTTSWRDGRLFNAII 165
Cdd:COG5069    88 NIGPQDIVDGNPKLILGLIWSLISRLTIATIN---EEGELTKHINLLLWCDEDTGGYKpEVDTFDFFRSWRDGLAFSALI 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  166 HRHKPMLIDMNKVYRQTNLE--NLDQAFSVAERDLGVTRLLDPEDV-DVPQPDEKSIITYVS------SLYD----AMPR 232
Cdd:COG5069   165 HDSRPDTLDPNVLDLQKKNKalNNFQAFENANKVIGIARLIGVEDIvNVSIPDERSIMTYVSwyiirfGLLEkidiALHR 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  233 VPGAQDGVRANElQLRwQEYRELVLLLLQWIRHHTAAFEERKFPSSFEEIEILWCQFLKFKETE--LPAKEAD-KNRSKV 309
Cdd:COG5069   245 VYRLLEADETLI-QLR-LPYEIILLRLLNLIHLKQANWKVVNFSKDVSDGENYTDLLNQLNALCsrAPLETTDlHSLAGQ 322
                         330       340
                  ....*....|....*....|....*....
gi 254675251  310 IYQSLEgAVQAGQLKIPPGYHPLDVEKEW 338
Cdd:COG5069   323 ILQNAE-KYDCRKYLPPAGNPKLDLAFVA 350
PTZ00121 PTZ00121
MAEBL; Provisional
1311-2016 2.52e-36

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 153.37  E-value: 2.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1311 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSiqEELQHL 1390
Cdd:PTZ00121 1101 EEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKA--EDAKKA 1178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1391 RQSSEAEIQAKAQQVEAAERSRmRIEEEIRVVRLQlETTERQRGGAEGELQALRaRAEEAeaqkRQAQEEAERLRRQVQD 1470
Cdd:PTZ00121 1179 EAARKAEEVRKAEELRKAEDAR-KAEAARKAEEER-KAEEARKAEDAKKAEAVK-KAEEA----KKDAEEAKKAEEERNN 1251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1471 ESQRKRQAEAELALRVKAEAEAAREKQRAlqalDELRlQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASF 1550
Cdd:PTZ00121 1252 EEIRKFEEARMAHFARRQAAIKAEEARKA----DELK-KAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEE 1326
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1551 AEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRlqAEEVaqqkslAQADAEKQ 1630
Cdd:PTZ00121 1327 AKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKK--AEEK------KKADEAKK 1398
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1631 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATA 1710
Cdd:PTZ00121 1399 KAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKK 1478
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1711 ATQKRQeleAELAKVRAEmevllASKARAEEESRSTSEKSKqrleAEAGRFRELAEEAARLRAlAEEAKRQRQLAEEDAA 1790
Cdd:PTZ00121 1479 AEEAKK---ADEAKKKAE-----EAKKKADEAKKAAEAKKK----ADEAKKAEEAKKADEAKK-AEEAKKADEAKKAEEK 1545
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1791 RQRAEAERvlTEKLAAISEatrlKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKASESE 1870
Cdd:PTZ00121 1546 KKADELKK--AEELKKAEE----KKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAK 1619
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1871 L--------ERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDtMRSKEQAELEAARQRQLAA 1942
Cdd:PTZ00121 1620 IkaeelkkaEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEE-AKKAEEDEKKAAEALKKEA 1698
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251 1943 EEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2016
Cdd:PTZ00121 1699 EEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEE 1772
PTZ00121 PTZ00121
MAEBL; Provisional
1687-2534 3.20e-29

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 129.88  E-value: 3.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1687 TEQGEQQRQLLEEELARLQHEATAATqkRQELEAELAKVR------AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1760
Cdd:PTZ00121 1033 TEYGNNDDVLKEKDIIDEDIDGNHEG--KAEAKAHVGQDEglkpsyKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGK 1110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1761 FRElAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEdeaf 1840
Cdd:PTZ00121 1111 AEE-ARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAE---- 1185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1841 QRRRLEEqaaLHKADIEERLAQLRKASEselerqkglvEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNA 1920
Cdd:PTZ00121 1186 EVRKAEE---LRKAEDARKAEAARKAEE----------ERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNE 1252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1921 EdtMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKValEEVERLKAKVEEARRLRERAEQesarq 2000
Cdd:PTZ00121 1253 E--IRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEK--KKADEAKKKAEEAKKADEAKKK----- 1323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2001 lqlAQEAAQKRLQAEEKAhafvvqqreeelqqtlqqeqnmldrlrseaeaarraaeeaeeareqaereaaQSRKQVEEAE 2080
Cdd:PTZ00121 1324 ---AEEAKKKADAAKKKA----------------------------------------------------EEAKKAAEAA 1348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2081 RLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQtLRQKAQVEQELTTLRLQL 2160
Cdd:PTZ00121 1349 KAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADE-LKKAAAAKKKADEAKKKA 1427
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2161 EETDHQksildEELQRLKAEVTEAARQRSQVEEelfsvRVQMEELGKlkaRIEAENRALILRDKDNTQRFLEE---EAEK 2237
Cdd:PTZ00121 1428 EEKKKA-----DEAKKKAEEAKKADEAKKKAEE-----AKKAEEAKK---KAEEAKKADEAKKKAEEAKKADEakkKAEE 1494
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2238 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK----EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2313
Cdd:PTZ00121 1495 AKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKadeaKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEE 1574
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2314 DKeQMAQQLVEETQgfqrtlEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKqAEEIGEKLHRTELATQEKV 2393
Cdd:PTZ00121 1575 DK-NMALRKAEEAK------KAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKK-AEEEKKKVEQLKKKEAEEK 1646
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2394 TLVQTL-------EIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQ-----EQILQETQALQKSFL 2461
Cdd:PTZ00121 1647 KKAEELkkaeeenKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEElkkkeAEEKKKAEELKKAEE 1726
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251 2462 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRK 2534
Cdd:PTZ00121 1727 ENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKK 1799
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1134-2018 5.22e-29

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 128.68  E-value: 5.22e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1134 ERDVEVERWRERVTQLLERwqavlaqtdvRQRELEQLGRQLRYYRESADplsawlqDAKRRQEQIQAVPIANCQAAREQL 1213
Cdd:COG1196   172 ERKEEAERKLERTEENLER----------LEDLLEELEKQLEKLERQAE-------KAERYQELKAELRELELALLLAKL 234
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1214 RQEKALLEEIErhgEKVEECQKFAKQYINAIKDYELQLITYKAQLEpvaspakkpkvqsgsesviqeyvDLRTRYSELTT 1293
Cdd:COG1196   235 KELRKELEELE---EELSRLEEELEELQEELEEAEKEIEELKSELE-----------------------ELREELEELQE 288
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1294 LTSQyikfISETLRRMEEEERLAEQQRAEERERLAEVEAALEKqrqlAEAHAQAKAQAELEAQELQRRMQEEVARREEAA 1373
Cdd:COG1196   289 ELLE----LKEEIEELEGEISLLRERLEELENELEELEERLEE----LKEKIEALKEELEERETLLEELEQLLAELEEAK 360
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1374 VDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQ 1453
Cdd:COG1196   361 EELEEKLSALLEELEELFEALREELAELEAELAEIRNELEELKREIESLEERLERLSERLEDLKEELKELEAELEELQTE 440
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1454 KRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERA-------- 1525
Cdd:COG1196   441 LEELNEELEELEEQLEELRDRLKELERELAELQEELQRLEKELSSLEARLDRLEAEQRASQGVRAVLEALESglpgvygp 520
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1526 --------RQVQVALETA--QRSAEVELQSKRAsfAEKTAQLERTLQEEHVTVAQLrEEAERRAQQQAEAERAREEAERE 1595
Cdd:COG1196   521 vaelikvkEKYETALEAAlgNRLQAVVVENEEV--AKKAIEFLKENKAGRATFLPL-DRIKPLRSLKSDAAPGFLGLASD 597
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1596 LERWQLKANEALRLRLQAEEVAqqKSLAQADAEKQKEEAEREARRRGKAE----------EQAVRQRELAEQELEKQRQL 1665
Cdd:COG1196   598 LIDFDPKYEPAVRFVLGDTLVV--DDLEQARRLARKLRIKYRIVTLDGDLvepsgsitggSRNKRSSLAQKRELKELEEE 675
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1666 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEEsrs 1745
Cdd:COG1196   676 LAELEAQLEKLEEELKSLKNELRSLEDLLEELRRQLEELERQLEELKRELAALEEELEQLQSRLEELEEELEELEEE--- 752
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1746 tSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKE 1825
Cdd:COG1196   753 -LEELQERLEELEEELESLEEALAKLKEEIEELEEKRQALQEELEELEEELEEAERRLDALERELESLEQRRERLEQEIE 831
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1826 AENERLRRLAEDEAFQRRRLEE---QAALHKADIEERLAQLRKAsESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKA 1902
Cdd:COG1196   832 ELEEEIEELEEKLDELEEELEElekELEELKEELEELEAEKEEL-EDELKELEEEKEELEEELRELESELAELKEEIEKL 910
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1903 AAGKAELELELGR---IRSNAEDTMRSKEQAELEAARQRQLAAeeeqrrreaeervqrslaAEEEAARQRKV---ALEEV 1976
Cdd:COG1196   911 RERLEELEAKLERlevELPELEEELEEEYEDTLETELEREIER------------------LEEEIEALGPVnlrAIEEY 972
                         890       900       910       920
                  ....*....|....*....|....*....|....*....|..
gi 254675251 1977 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2018
Cdd:COG1196   973 EEVEERYEELKSQREDLEEAKEKLLEVIEELDKEKRERFKET 1014
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
859-936 5.92e-29

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


Pssm-ID: 436447  Cd Length: 78  Bit Score: 112.30  E-value: 5.92e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251   859 LAWQSLSRDIQLIRSWSLVTFRTLKPEEQRQALRNLELHYQAFLRDSQDAGGFGPEDRLVAEREYGSCSRHYQQLLQS 936
Cdd:pfam18373    1 VSWQYLLKDIERIRSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNACQQHYQTLLVS 78
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1208-1996 1.05e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 120.93  E-value: 1.05e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1208 AAREQLRQEKALLEEIERHGEKVEECQKFAKQYI---NAIKDYELQLITYkaqlepvaspakkpkvqsgsesviqEYVDL 1284
Cdd:TIGR02168  183 RTRENLDRLEDILNELERQLKSLERQAEKAERYKelkAELRELELALLVL-------------------------RLEEL 237
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1285 RTRYSELTTLTSQYikfiSETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQE 1364
Cdd:TIGR02168  238 REELEELQEELKEA----EEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLAN 313
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1365 EVARREEAAVDAQQQKRSIQE------ELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEG 1438
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDElaeelaELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLEL 393
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1439 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRAlqALDELRLQAEEAERRLR 1518
Cdd:TIGR02168  394 QIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQE--ELERLEEALEELREELE 471
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1519 QAEAERarqvqvaletaqRSAEVELQSKRASFAEKTAQLERtLQEEHVTVAQLREEAERRAQQQAEAERAREEAerelER 1598
Cdd:TIGR02168  472 EAEQAL------------DAAERELAQLQARLDSLERLQEN-LEGFSEGVKALLKNQSGLSGILGVLSELISVD----EG 534
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1599 WQLKANEALRLRLQA---EEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQE----------------- 1658
Cdd:TIGR02168  535 YEAAIEAALGGRLQAvvvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIegflgvakdlvkfdpkl 614
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1659 --------------------LEKQRQL-----------------------AEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1695
Cdd:TIGR02168  615 rkalsyllggvlvvddldnaLELAKKLrpgyrivtldgdlvrpggvitggSAKTNSSILERRREIEELEEKIEELEEKIA 694
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1696 LLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK----SKQRLEAEAGRfRELAEEAARL 1771
Cdd:TIGR02168  695 ELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERiaqlSKELTELEAEI-EELEERLEEA 773
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1772 RALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAeialKEKEAENERLRRLAEDEAFQRRRLEEQAAL 1851
Cdd:TIGR02168  774 EEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEA----ANLRERLESLERRIAATERRLEDLEEQIEE 849
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1852 HKADIEERLAQLRKASESELERQKGLvEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQ-- 1929
Cdd:TIGR02168  850 LSEDIESLAAEIEELEELIEELESEL-EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQle 928
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1930 ---AELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRkvalEEVERLKAKVEEARRLRERAEQE 1996
Cdd:TIGR02168  929 lrlEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEAR----RRLKRLENKIKELGPVNLAAIEE 994
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
14-111 2.08e-25

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 103.16  E-value: 2.08e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251     14 KTFTKWVNKHLIKA-QRHISDLYEDLRDGHNLISLLEVLSGDSLPREK---GRMRFHKLQNVQIALDYLRHRQVKLVNIR 89
Cdd:smart00033    1 KTLLRWVNSLLAEYdKPPVTNFSSDLKDGVALCALLNSLSPGLVDKKKvaaSLSRFKKIENINLALSFAEKLGGKVVLFE 80
                            90       100
                    ....*....|....*....|..
gi 254675251     90 NDDIADGnPKLTLGLIWTIILH 111
Cdd:smart00033   81 PEDLVEG-PKLILGVIWTLISL 101
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
126-232 8.21e-25

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596  Cd Length: 109  Bit Score: 101.59  E-value: 8.21e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   126 MTAKEKLLLWSQRMVEGY-QGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVY--RQTNLENLDQAFSVAERDLGVTR 202
Cdd:pfam00307    1 LELEKELLRWINSHLAEYgPGVRVTNFTTDLRDGLALCALLNKLAPGLVDKKKLNksEFDKLENINLALDVAEKKLGVPK 80
                           90       100       110
                   ....*....|....*....|....*....|.
gi 254675251   203 -LLDPEDVDvpQPDEKSIITYVSSLYDAMPR 232
Cdd:pfam00307   81 vLIEPEDLV--EGDNKSVLTYLASLFRRFQA 109
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
11-114 3.45e-24

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596  Cd Length: 109  Bit Score: 100.05  E-value: 3.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    11 VQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLP-REKGRMRFHKLQNVQIALDYLRHRQ-VKLV 86
Cdd:pfam00307    2 ELEKELLRWINSHLAEYGPGvrVTNFTTDLRDGLALCALLNKLAPGLVDkKKLNKSEFDKLENINLALDVAEKKLgVPKV 81
                           90       100
                   ....*....|....*....|....*...
gi 254675251    87 NIRNDDIADGNPKLTLGLIWTIILHFQI 114
Cdd:pfam00307   82 LIEPEDLVEGDNKSVLTYLASLFRRFQA 109
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1646-2484 5.92e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.07  E-value: 5.92e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1646 EQAVRQRELAEQELEKQRQLAegtAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKV 1725
Cdd:TIGR02168  210 EKAERYKELKAELRELELALL---VLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEEL 286
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1726 RAEMEVLLASKARAEEESRSTSEkskqrleaeagRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEK-- 1803
Cdd:TIGR02168  287 QKELYALANEISRLEQQKQILRE-----------RLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELes 355
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1804 -LAAISEATRLKTEAEIALKEKEAENERLRRLaedeafqRRRLEEQAALHKADIEERLAQLrKASESELERQKGLVEDtl 1882
Cdd:TIGR02168  356 lEAELEELEAELEELESRLEELEEQLETLRSK-------VAQLELQIASLNNEIERLEARL-ERLEDRRERLQQEIEE-- 425
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1883 RQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEdtmrsKEQAELEAARQRQLaaeeeqrrreaeervqrSLAAE 1962
Cdd:TIGR02168  426 LLKKLEEAELKELQAELEELEEELEELQEELERLEEALE-----ELREELEEAEQALD-----------------AAERE 483
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1963 EEAARQRKVALEEV-ERLKAKVEEARRLRERAEQ------------ESARQLQLAQEAA---------QKRLQAEEKAHA 2020
Cdd:TIGR02168  484 LAQLQARLDSLERLqENLEGFSEGVKALLKNQSGlsgilgvlseliSVDEGYEAAIEAAlggrlqavvVENLNAAKKAIA 563
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2021 FVVQQREEELQQTLqqeqnmLDRLRSEAEAARRAAEEAEEAREQAEREAAqsrkqVEEAERLKQSAEEQAQAQAQAQAAA 2100
Cdd:TIGR02168  564 FLKQNELGRVTFLP------LDSIKGTEIQGNDREILKNIEGFLGVAKDL-----VKFDPKLRKALSYLLGGVLVVDDLD 632
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2101 EKLRKEAEQEAARRAQAEQAALKQKQAADAEmeKHKKFAEQTLRQKaqveQELTTLRLQLEETDHQKSILDEELQRLKAE 2180
Cdd:TIGR02168  633 NALELAKKLRPGYRIVTLDGDLVRPGGVITG--GSAKTNSSILERR----REIEELEEKIEELEEKIAELEKALAELRKE 706
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2181 VTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALiLRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQ 2260
Cdd:TIGR02168  707 LEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL-EERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIE 785
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2261 LAEEDLAQQRALAEKmLKEKMQAVQ-EATRLKAEAellqQQKELAQEQARRLQEDKEQMAQQLVEETQgfqrtleaerqr 2339
Cdd:TIGR02168  786 ELEAQIEQLKEELKA-LREALDELRaELTLLNEEA----ANLRERLESLERRIAATERRLEDLEEQIE------------ 848
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2340 qlEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2419
Cdd:TIGR02168  849 --ELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251  2420 LEREKEKLKQE-AKLLQLKSEEMQTVQQEqilqetqALQKSFLSEKDSLLQRERfIEQEKAKLEQL 2484
Cdd:TIGR02168  927 LELRLEGLEVRiDNLQERLSEEYSLTLEE-------AEALENKIEDDEEEARRR-LKRLENKIKEL 984
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1650-2441 4.94e-23

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 109.03  E-value: 4.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1650 RQRELAEQELEKQRQLaegtaqQRLAAEQELIRLRAETEQgeqqRQLLEEELARLQHEATAATQKRQELEAELAKVRAEM 1729
Cdd:COG1196   207 RQAEKAERYQELKAEL------RELELALLLAKLKELRKE----LEELEEELSRLEEELEELQEELEEAEKEIEELKSEL 276
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1730 EVLLASKARAEEESRSTSEKsKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISE 1809
Cdd:COG1196   277 EELREELEELQEELLELKEE-IEELEGEISLLRERLEELENELEELEERLEELKEKIEALKEELEERETLLEELEQLLAE 355
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1810 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLrkasESELERQKGLVEDTLRQRRQVE 1889
Cdd:COG1196   356 LEEAKEELEEKLSALLEELEELFEALREELAELEAELAEIRNELEELKREIESL----EERLERLSERLEDLKEELKELE 431
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1890 EEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQRQlaaeeeqrrreaeervqrslaaEEEAARQR 1969
Cdd:COG1196   432 AELEELQTELEELNEELEELEEQLEELRDRLKELERELAELQEELQRLEK----------------------ELSSLEAR 489
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1970 KVALEEVERLKAKVEEARRLRERAEQESARQL----------QLAQEAAqkrlqAEEKAHAFVVQQREEELQQTLQQEQN 2039
Cdd:COG1196   490 LDRLEAEQRASQGVRAVLEALESGLPGVYGPVaelikvkekyETALEAA-----LGNRLQAVVVENEEVAKKAIEFLKEN 564
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2040 --------MLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQV-------------EEAERLkqsAEEQAQAQAQAQA 2098
Cdd:COG1196   565 kagratflPLDRIKPLRSLKSDAAPGFLGLASDLIDFDPKYEPAVrfvlgdtlvvddlEQARRL---ARKLRIKYRIVTL 641
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2099 AAEKLRKEAE----QEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQ----KAQVEQELTTLRLQLEETDHQKSIL 2170
Cdd:COG1196   642 DGDLVEPSGSitggSRNKRSSLAQKRELKELEEELAELEAQLEKLEEELKSlkneLRSLEDLLEELRRQLEELERQLEEL 721
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2171 DEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRfLEEEAEKMKQVAEEAARLSV 2250
Cdd:COG1196   722 KRELAALEEELEQLQSRLEELEEELEELEEELEELQERLEELEEELESLEEALAKLKEE-IEELEEKRQALQEELEELEE 800
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2251 AAQEAARLRQLAEEDLAQQRALAEKMLKEKmqavqeatrlkaeAELLQQQKELAQEQA------RRLQEDKEQMAQQLVE 2324
Cdd:COG1196   801 ELEEAERRLDALERELESLEQRRERLEQEI-------------EELEEEIEELEEKLDeleeelEELEKELEELKEELEE 867
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2325 ETQGFQRT---LEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2401
Cdd:COG1196   868 LEAEKEELedeLKELEEEKEELEEELRELESELAELKEEIEKLRERLEELEAKLERLEVELPELEEELEEEYEDTLETEL 947
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 2402 QRQQSDHDA----------------ERLREAIAELEREKEKLKQEAKLLQLKSEEM 2441
Cdd:COG1196   948 EREIERLEEeiealgpvnlraieeyEEVEERYEELKSQREDLEEAKEKLLEVIEEL 1003
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
758-824 7.16e-22

SH3 domain; This entry represents an SH3 domain.


Pssm-ID: 407754  Cd Length: 65  Bit Score: 91.55  E-value: 7.16e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251   758 QLKPRNpaHPVRGHVPLIAVCDYKQVEVTVHKGDQCQLVGPAQPSHWKVLSGSSSEAAVPSVCFLVP 824
Cdd:pfam17902    1 PLKQRR--SPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The ...
1438-2332 2.95e-19

RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 96.58  E-value: 2.95e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1438 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR-QAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERR 1516
Cdd:pfam02463  163 AGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKlKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLL 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1517 LRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHvtvaqlreeaeRRAQQQAEAERAREEAEREL 1596
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLL-----------AKEEEELKSELLKLERRKVD 311
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1597 ERWQLKANEALRLRLQAEEVAQQKSLAQAdaEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1676
Cdd:pfam02463  312 DEEKLKESEKEKKKAEKELKKEKEEIEEL--EKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSA 389
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1677 EQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1756
Cdd:pfam02463  390 AKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKK 469
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1757 EagrFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAE 1836
Cdd:pfam02463  470 S---EDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAIS 546
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1837 DEAFQRRRLEEQAALHKADIEERLAQLRKASESeLERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRI 1916
Cdd:pfam02463  547 TAVIVEVSATADEVEERQKLVRALTELPLGARK-LRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVV 625
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1917 RSNAEDTMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQE 1996
Cdd:pfam02463  626 EGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKE 705
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1997 SARQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQV 2076
Cdd:pfam02463  706 QREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEK 785
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2077 EEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2156
Cdd:pfam02463  786 LKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITK 865
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2157 RLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAE 2236
Cdd:pfam02463  866 EELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEA 945
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2237 KMKQVAEEAarlsvaaqeaarLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2316
Cdd:pfam02463  946 DEKEKEENN------------KEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIE 1013
                          890
                   ....*....|....*.
gi 254675251  2317 QMAQQLVEETQGFQRT 2332
Cdd:pfam02463 1014 ETCQRLKEFLELFVSI 1029
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
130-226 3.58e-19

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 85.45  E-value: 3.58e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    130 EKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTN----LENLDQAFSVAERDLGVTRLLD 205
Cdd:smart00033    1 KTLLRWVNSLLAEYDKPPVTNFSSDLKDGVALCALLNSLSPGLVDKKKVAASLSrfkkIENINLALSFAEKLGGKVVLFE 80
                            90       100
                    ....*....|....*....|.
gi 254675251    206 PEDVDVPQPDEKSIITYVSSL 226
Cdd:smart00033   81 PEDLVEGPKLILGVIWTLISL 101
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
991-1527 7.80e-18

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 223496 [Multi-domain]  Cd Length: 908  Bit Score: 91.75  E-value: 7.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  991 QQKAQAEVEGLGKGVARLSAEAEKVLALPE-----PSPAAPTLRSELELTLGKLEQVRSLSA-IYLEKLKTISLVIRSTQ 1064
Cdd:COG0419   191 EGQLSELLEDIEDLLEALEEELKELKKLEEiqeeqEEEELEQEIEALEERLAELEEEKERLEeLKARLLEIESLELEALK 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1065 GAEEVLKTHEEQLKEAQAVPATLQELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRE 1144
Cdd:COG0419   271 IREEELRELERLLEELEEKIERLEELEREIEELEEELEGLRALLEELEELLEKLKSLEERLEKLEEKLEKLESELEELAE 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1145 RVTQLLERWQAvlaqtdvRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAVPIANCQAAREQLRQEKALLEEIE 1224
Cdd:COG0419   351 EKNELAKLLEE-------RLKELEERLEELEKELEKALERLKQLEEAIQELKEELAELSAALEEIQEELEELEKELEELE 423
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1225 RHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEP-------------VASPAKKPKVQSGSESVIQEYVDLRTRYSEL 1291
Cdd:COG0419   424 RELEELEEEIKKLEEQINQLESKELMIAELAGAGEKcpvcgqelpeeheKELLELYELELEELEEELSREKEEAELREEI 503
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1292 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLaeahaqAKAQAELEAQELQRRMQEEVARREE 1371
Cdd:COG0419   504 EELEKELRELEEELIELLELEEALKEELEEKLEKLENLLEELEELKEKL------QLQQLKEELRQLEDRLQELKELLEE 577
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1372 AAvdaqqQKRSIQEELQHLRQSSEaeiQAKAQQVEAAERSRmRIEEEIRvvRLQLETTERQRGGAEGELQALRARAEEA- 1450
Cdd:COG0419   578 LR-----LLRTRKEELEELRERLK---ELKKKLKELEERLS-QLEELLQ--SLELSEAENELEEAEEELESELEKLNLQa 646
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1451 --EAQKRQAQEEAERLRRQVQDESQRKRQ---AEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERA 1525
Cdd:COG0419   647 elEELLQAALEELEEKVEELEAEIRRELQrieNEEQLEEKLEELEQLEEELEQLREELEELLKKLGEIEQLIEELESRKA 726

                  ..
gi 254675251 1526 RQ 1527
Cdd:COG0419   727 EL 728
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
929-1563 1.28e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 87.80  E-value: 1.28e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   929 HYQQLLQSLEQGEQEESRCQRcisELKDIRLQLEACETR-TVHRLRLpldkdpaRECAQRIAEQQK----AQAEVEGLGK 1003
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEE---ELEELTAELQELEEKlEELRLEV-------SELEEEIEELQKelyaLANEISRLEQ 302
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1004 GVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKTHEEQLKE--- 1079
Cdd:TIGR02168  303 QKQILRERLANLERqLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEqle 382
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1080 --AQAVPATLQELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQ-QRHGERDVEVERWRERVTQLLERWQAV 1156
Cdd:TIGR02168  383 tlRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAElKELQAELEELEEELEELQEELERLEEA 462
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1157 LAQTDVRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAvPIANCQAAREQLRQEKALLEEIERHGEKVEEC--- 1233
Cdd:TIGR02168  463 LEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSE-GVKALLKNQSGLSGILGVLSELISVDEGYEAAiea 541
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1234 -------------QKFAKQYINAIKDYELQLITYKA--QLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSE----LTTL 1294
Cdd:TIGR02168  542 alggrlqavvvenLNAAKKAIAFLKQNELGRVTFLPldSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKlrkaLSYL 621
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1295 TSQYikFISETL-------RRMEEEERL--------------------AEQQRAEERERLAEVEAALEK-QRQLAEAHAQ 1346
Cdd:TIGR02168  622 LGGV--LVVDDLdnalelaKKLRPGYRIvtldgdlvrpggvitggsakTNSSILERRREIEELEEKIEElEEKIAELEKA 699
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1347 ----AKAQAELEAQELQRRMQEEVARREEAAVDAQQQK-RSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRV 1421
Cdd:TIGR02168  700 laelRKELEELEEELEQLRKELEELSRQISALRKDLARlEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE 779
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1422 VRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQ 1501
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAA 859
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675251  1502 ALDELRLQAEEAERRLRQAEAERArQVQVALETAqRSAEVELQSKRASFAEKTAQLERTLQE 1563
Cdd:TIGR02168  860 EIEELEELIEELESELEALLNERA-SLEEALALL-RSELEELSEELRELESKRSELRRELEE 919
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The ...
1786-2572 3.55e-16

RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 86.56  E-value: 3.55e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1786 EEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAlhkadIEERLAQLRK 1865
Cdd:pfam02463  143 KIEIIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAK-----KALEYYQLKE 217
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1866 ASESELERQKGLVEDTLRQRRQVEEEimalkvsfEKAAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQRQLAAEEE 1945
Cdd:pfam02463  218 KLELEEEYLLYLDYLKLNEERIDLLQ--------ELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELK 289
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1946 QRRREAEERVQRSLAAEeeaaRQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKahafvVQQ 2025
Cdd:pfam02463  290 LLAKEEEELKSELLKLE----RRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEE-----EEE 360
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2026 REEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERlKQSAEEQAQAQAQAQAAAEKLRK 2105
Cdd:pfam02463  361 LEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQ-LEDLLKEEKKEELEILEEEEESI 439
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2106 EAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELqrlkaEVTEAA 2185
Cdd:pfam02463  440 ELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSG-----LKVLLA 514
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2186 RQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAE------EAARLSVAAQEAARLR 2259
Cdd:pfam02463  515 LIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTElplgarKLRLLIPKLKLPLKSI 594
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2260 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQR 2339
Cdd:pfam02463  595 AVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKE 674
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2340 QLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2419
Cdd:pfam02463  675 LLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEK 754
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2420 LEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-KQLREE 2498
Cdd:pfam02463  755 SRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEeKIKEEE 834
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251  2499 QQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEHRA 2572
Cdd:pfam02463  835 LEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQK 908
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3428-3466 1.42e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 72.76  E-value: 1.42e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3428 LLEAQVATGGIIDPVHSHRLPVDVAYQRGYFDEEMNRVL 3466
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4006-4044 2.58e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 72.37  E-value: 2.58e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  4006 LLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEIL 4044
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
2769-2807 5.21e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 71.22  E-value: 5.21e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  2769 LLEAQIATGGIIDPVHSHRVPVDVAYKRGYFDEEMNRIL 2807
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3687-3725 7.55e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 70.83  E-value: 7.55e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3687 LLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3725
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
583-761 2.70e-14

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 74.79  E-value: 2.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  583 LHGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESYSALMRELEMKEKKIKEIQNTGDRLLREDHPARPTVESFQ 662
Cdd:cd00176     2 LQQFLRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  663 AALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLQKLQETLRRKYSCDrtiTVTRLEDLLQDAQDEKEQLNEY 742
Cdd:cd00176    82 EELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGK---DLESVEELLKKHKELEEELEAH 158
                         170
                  ....*....|....*....
gi 254675251  743 KGHLSGLAKRAKAIVQLKP 761
Cdd:cd00176   159 EPRLKSLNELAEELLEEGH 177
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3021-3059 2.04e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 66.98  E-value: 2.04e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3021 LLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPELHEKL 3059
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4275-4313 8.66e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 65.05  E-value: 8.66e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  4275 LLEAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMVDRI 4313
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3352-3390 2.53e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 63.51  E-value: 2.53e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3352 LLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKL 3390
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3097-3135 3.02e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 63.51  E-value: 3.02e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3097 LLDAQLSTGGIVDPSKSHRVPLDVAYARGYLDKETNRAL 3135
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
2693-2731 4.64e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 63.13  E-value: 4.64e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  2693 LLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKL 2731
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3930-3968 5.99e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 62.74  E-value: 5.99e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3930 LLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKL 3968
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3763-3801 6.67e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 62.36  E-value: 6.67e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3763 LLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3801
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4351-4389 6.43e-11

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 59.66  E-value: 6.43e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  4351 FLEVQYLTGGLIEPDTPGRVSLDEALQRGTVDARTAQKL 4389
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
4273-4310 1.45e-09

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 55.95  E-value: 1.45e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 254675251   4273 QRLLEAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMV 4310
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
1067-1257 7.15e-09

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 59.00  E-value: 7.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1067 EEVLKTHEEQLKEAQaVPATLQELEATKASLKKLRAQAEAQQPVFNTLrdelrgaQEVGERLQQRHGERDVEVerwRERV 1146
Cdd:cd00176    13 EAWLSEKEELLSSTD-YGDDLESVEALLKKHEALEAELAAHEERVEAL-------NELGEQLIEEGHPDAEEI---QERL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1147 TQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADpLSAWLQDAKRRQEQIQavPIANCQAAREQLRQEKALLEEIERH 1226
Cdd:cd00176    82 EELNQRWEELRELAEERRQRLEEALDLQQFFRDADD-LEQWLEEKEAALASED--LGKDLESVEELLKKHKELEEELEAH 158
                         170       180       190
                  ....*....|....*....|....*....|.
gi 254675251 1227 GEKVEECQKFAKQYINAIKDYELQLITYKAQ 1257
Cdd:cd00176   159 EPRLKSLNELAEELLEEGHPDADEEIEEKLE 189
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1012-1558 9.23e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.00  E-value: 9.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1012 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKTHEEQLKEaqaVPATLQELE 1091
Cdd:PRK03918  203 EEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEE---LKKEIEELE 279
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1092 ATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLqqrhgerdveverwrERVTQLLERWQAVLAQTDVRQRELEQLG 1171
Cdd:PRK03918  280 EKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRL---------------SRLEEEINGIEERIKELEEKEERLEELK 344
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1172 RQLRYYRESADPLSAW---LQDAKRRQEQIqavpiancqaarEQLRQEKALL--EEIERHGEKVEECQKFAKQYINAIKD 1246
Cdd:PRK03918  345 KKLKELEKRLEELEERhelYEEAKAKKEEL------------ERLKKRLTGLtpEKLEKELEELEKAKEEIEEEISKITA 412
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1247 YELQLITYKAQLEPVASPAKKPKVQS---GSESVIQEYVDLRTRYSElttltsqYIKFISETLRRMEEEERlaeqqraEE 1323
Cdd:PRK03918  413 RIGELKKEIKELKKAIEELKKAKGKCpvcGRELTEEHRKELLEEYTA-------ELKRIEKELKEIEEKER-------KL 478
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1324 RERLAEVEAALEKQRQLAEAHAQAKAQAELEaQELQRRMQEEVARREEAAvdaqqqkRSIQEELQHLrqssEAEIQAKAQ 1403
Cdd:PRK03918  479 RKELRELEKVLKKESELIKLKELAEQLKELE-EKLKKYNLEELEKKAEEY-------EKLKEKLIKL----KGEIKSLKK 546
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1404 QVEAAERsrmrIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELA 1483
Cdd:PRK03918  547 ELEKLEE----LKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKELK 622
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 1484 lRVKAEAEAAREK-QRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLE 1558
Cdd:PRK03918  623 -KLEEELDKAFEElAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLE 697
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1126-1433 1.43e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 61.29  E-value: 1.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1126 ERLQQRHGERDVEVERWR-----ERVTQL-LERWQAVLAQTD----VRQRELEQLGrqlryyresadplsawLQDAKRRQ 1195
Cdd:pfam17380  299 ERLRQEKEEKAREVERRRkleeaEKARQAeMDRQAAIYAEQErmamERERELERIR----------------QEERKREL 362
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1196 EQIQAVPIAncqAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVaspakKPKVQSGSE 1275
Cdd:pfam17380  363 ERIRQEEIA---MEISRMRELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQI-----RAEQEEARQ 434
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1276 SVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEaalEKQRQLAEAHAQAKAQAELEA 1355
Cdd:pfam17380  435 REVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAE---EQRRKILEKELEERKQAMIEE 511
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251  1356 QELQRRMQEEVARREEAAvdAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAA-ERSRMRIEEEIRVVRLQLETTERQR 1433
Cdd:pfam17380  512 ERKRKLLEKEMEERQKAI--YEEERRREAEEERRKQQEMEERRRIQEQMRKATeERSRLEAMEREREMMRQIVESEKAR 588
PLEC smart00250
Plectin repeat;
4004-4040 9.45e-08

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 50.56  E-value: 9.45e-08
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   4004 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEM 4040
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4107-4135 5.27e-07

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 48.49  E-value: 5.27e-07
                           10        20
                   ....*....|....*....|....*....
gi 254675251  4107 IVDPETGKEMSVYEAYRKGLIDHQTYLEL 4135
Cdd:pfam00681   11 IIDPVTGERLSVEEALKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
3685-3720 6.77e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 48.25  E-value: 6.77e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 254675251   3685 RLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE 3720
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
PLEC smart00250
Plectin repeat;
3890-3927 2.37e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.71  E-value: 2.37e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 254675251   3890 QKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTA 3927
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
3095-3131 3.58e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.32  E-value: 3.58e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3095 LRLLDAQLSTGGIVDPSKSHRVPLDVAYARGYLDKET 3131
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
PLEC smart00250
Plectin repeat;
2768-2803 3.84e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.32  E-value: 3.84e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 254675251   2768 RLLEAQIATGGIIDPVHSHRVPVDVAYKRGYFDEEM 2803
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3892-3930 4.64e-06

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 45.79  E-value: 4.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3892 FLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFEL 3930
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
2249-2527 4.66e-06

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 380155 [Multi-domain]  Cd Length: 1848  Bit Score: 53.30  E-value: 4.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2249 SVAAQEAARLRQLAEEDLAQQRALAEKmlkekmqavqeatrlkaeaellqqqkELAQEQARRLQEDKeqmaQQLVEETQG 2328
Cdd:NF012221 1538 SESSQQADAVSKHAKQDDAAQNALADK--------------------------ERAEADRQRLEQEK----QQQLAAISG 1587
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2329 FQRTLEAERQRQLEMSAEAERlklrmaemsraQARAEEdaqrfrkqAEEIgeklhrtelaTQEKVTLVQTLEIQRQQSDH 2408
Cdd:NF012221 1588 SQSQLESTDQNALETNGQAQR-----------DAILEE--------SRAV----------TKELTTLAQGLDALDSQATY 1638
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2409 DAE---RLREAIAE--LEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSllqrerfiEQEKAKLEQ 2483
Cdd:NF012221 1639 AGEsgdQWRNPFAGglLDRVQEQLDDAKKISGKQLADAKQRHVDNQQKVKDAVAKSEAGVAQG--------EQNQANAEQ 1710
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 254675251 2484 LFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRR-QREA 2527
Cdd:NF012221 1711 DIDDAKADAEKRKDDALAKQNEAQQAESDANAAANDAQSRgEQDA 1755
PLEC smart00250
Plectin repeat;
3426-3462 6.52e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 45.55  E-value: 6.52e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3426 IRLLEAQVATGGIIDPVHSHRLPVDVAYQRGYFDEEM 3462
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
SPEC smart00150
Spectrin repeats;
584-676 6.76e-06

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 47.71  E-value: 6.76e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    584 HGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESYSALMRELEMKEKKIKEIQNTGDRLLREDHPARPTVESFQA 663
Cdd:smart00150    1 QQFLRDADELEAWLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLE 80
                            90
                    ....*....|...
gi 254675251    664 ALQTQWSWMLQLC 676
Cdd:smart00150   81 ELNERWEELKELA 93
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
1616-1937 7.59e-06

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 380155 [Multi-domain]  Cd Length: 1848  Bit Score: 52.53  E-value: 7.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1616 VAQQKSLAQADA--EKQKEEAEREARRRGKAEEQAVRQRelaeQELEKQRQLAEGTAQQrlaAEQELIRLRAETEQGEQQ 1693
Cdd:NF012221 1535 VATSESSQQADAvsKHAKQDDAAQNALADKERAEADRQR----LEQEKQQQLAAISGSQ---SQLESTDQNALETNGQAQ 1607
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1694 RQLLEEELARLQHEATAATQKRQELEAELAKV-------RAEMEVLLasKARAEEESRSTSEKSKQRLEAEAGRF----R 1762
Cdd:NF012221 1608 RDAILEESRAVTKELTTLAQGLDALDSQATYAgesgdqwRNPFAGGL--LDRVQEQLDDAKKISGKQLADAKQRHvdnqQ 1685
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1763 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1842
Cdd:NF012221 1686 KVKDAVAKSEAGVAQGEQNQANAEQDIDDAKADAEKRKDDALAKQNEAQQAESDANAAANDAQSRGEQDASAAENKANQA 1765
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1843 RRLEEQAALHKADIEERlaqlRKASESELERQKGLVEDtlrqrrqVEEEIMALKVSFEKAAAGKaelelelgrirsNAED 1922
Cdd:NF012221 1766 QADAKGAKQDESDKPNR----QGAAGSGLSGKAYSVEG-------VAEPGSHINPDSPAAADGR------------FSEG 1822
                         330
                  ....*....|....*
gi 254675251 1923 tMRSKEQAELEAARQ 1937
Cdd:NF012221 1823 -LTEQEQEALEGATN 1836
PLEC smart00250
Plectin repeat;
3058-3094 1.81e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.40  E-value: 1.81e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3058 KLLSAEKAVTGYRDPYSGQSVSLFQALKKGLIPREQG 3094
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3314-3352 2.02e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 44.25  E-value: 2.02e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3314 LLQGSGCLAGIYLEDSKEKVTIYEAMRRGLLRPSTATLL 3352
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
2655-2693 3.57e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 43.48  E-value: 3.57e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  2655 YLKGRSSIAGLLLKPTNEKLSVYTALQRQLLSPGTALIL 2693
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
4349-4386 3.81e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.24  E-value: 3.81e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 254675251   4349 QRFLEVQYLTGGLIEPDTPGRVSLDEALQRGTVDARTA 4386
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
3314-3349 3.93e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.24  E-value: 3.93e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 254675251   3314 LLQGSGCLAGIYLEDSKEKVTIYEAMRRGLLRPSTA 3349
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
4100-4128 4.33e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.24  E-value: 4.33e-05
                            10        20
                    ....*....|....*....|....*....
gi 254675251   4100 VRKRRVVIVDPETGKEMSVYEAYRKGLID 4128
Cdd:smart00250    6 AQSAIGGIIDPETGQKLSVEEALRRGLID 34
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
1642-2020 6.40e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 411407 [Multi-domain]  Cd Length: 684  Bit Score: 49.24  E-value: 6.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1642 GKAEEQAVRQRELAEQELEK-----QRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQHEATAATQK 1714
Cdd:NF033838   50 SSGNESQKEHAKEVESHLEKilseiQKSLDKRKHTQNVALNKKLSDIKTEylYELNVLKEKSEAELTSKTKKELDAAFEQ 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1715 RQELEAELAKVRAEMEVLLA-----SKARAEEESRSTSEKSKQRLEAEAGRFrELAEEAARLRALAEEAKRQRQLAEEDA 1789
Cdd:NF033838  130 FKKDTLEPGKKVAEATKKVEeaekkAKDQKEEDRRNYPTNTYKTLELEIAES-DVEVKKAELELVKEEAKEPRDEEKIKQ 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1790 ARQRAEAERvlteklaaiSEATRLKteaEIALKEKEAENERLRR------------LAEDEAFQRRRLEEQAALHKADIE 1857
Cdd:NF033838  209 AKAKVESKK---------AEATRLE---KIKTDREKAEEEAKRRadaklkeaveknVATSEQDKPKRRAKRGVLGEPATP 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1858 ERLAQLRKASESELERQKgLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAE------------LELELgrirsnAEDTMR 1925
Cdd:NF033838  277 DKKENDAKSSDSSVGEET-LPSPSLKPEKKVAEAEKKVEEAKKKAKDQKEEdrrnyptntyktLELEI------AESDVK 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1926 SKEqAELEAARQRqlaaeeeqrrreaeervqrslAAEEEAARQRKVALEEVERLKA---KVEEARRLRERAEQESARQLQ 2002
Cdd:NF033838  350 VKE-AELELVKEE---------------------AKEPRNEEKIKQAKAKVESKKAeatRLEKIKTDRKKAEEEAKRKAA 407
                         410
                  ....*....|....*...
gi 254675251 2003 LAQEAAQKRLQAEEKAHA 2020
Cdd:NF033838  408 EEDKVKEKPAEQPQPAPA 425
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
2122-2340 7.70e-05

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 380155 [Multi-domain]  Cd Length: 1848  Bit Score: 49.45  E-value: 7.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2122 LKQKQAA-DAEMEKHKKFAE-QTLRQ-KAQVEQELTTLRLQLEETDHQksildeelqrlkAEVTEAARQRSQVEEELFSV 2198
Cdd:NF012221 1551 AKQDDAAqNALADKERAEADrQRLEQeKQQQLAAISGSQSQLESTDQN------------ALETNGQAQRDAILEESRAV 1618
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2199 RVQMEELGKlkaRIEA----------------ENRALILRDK-----DNTQRFLEEEAEKMKQ--------VAEEAARLS 2249
Cdd:NF012221 1619 TKELTTLAQ---GLDAldsqatyagesgdqwrNPFAGGLLDRvqeqlDDAKKISGKQLADAKQrhvdnqqkVKDAVAKSE 1695
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2250 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQlveETQGF 2329
Cdd:NF012221 1696 AGVAQGEQNQANAEQDIDDAKADAEKRKDDALAKQNEAQQAESDANAAANDAQSRGEQDASAAENKANQAQA---DAKGA 1772
                         250
                  ....*....|.
gi 254675251 2330 QRTLEAERQRQ 2340
Cdd:NF012221 1773 KQDESDKPNRQ 1783
PLEC smart00250
Plectin repeat;
3761-3797 7.88e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 42.47  E-value: 7.88e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3761 LRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDT 3797
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
PLEC smart00250
Plectin repeat;
3648-3684 1.04e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 42.08  E-value: 1.04e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3648 RYLYGTGAVAGVYLPGSRQTLTIYQALKKGLLSAEVA 3684
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
3930-3964 1.34e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.70  E-value: 1.34e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 254675251   3930 LLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEF 3964
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
PLEC smart00250
Plectin repeat;
3724-3760 1.60e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.70  E-value: 1.60e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3724 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPAEEA 3760
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
4239-4272 1.82e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.31  E-value: 1.82e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 254675251   4239 EETGPVAGILDTETLEKVSITEAMHRNLVDNITG 4272
Cdd:smart00250    5 EAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3649-3687 4.46e-04

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 40.40  E-value: 4.46e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3649 YLYGTGAVAGVYLPGSRQTLTIYQALKKGLLSAEVARLL 3687
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
PLEC smart00250
Plectin repeat;
3350-3385 4.67e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.16  E-value: 4.67e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 254675251   3350 TLLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPE 3385
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
PLEC smart00250
Plectin repeat;
2693-2726 4.76e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.16  E-value: 4.76e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 254675251   2693 LLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2726
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
2213-2330 5.03e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 45.26  E-value: 5.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2213 EAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEaarlRQLAEEDLAQQRALAE--KMLKEKMQavQEATRL 2290
Cdd:cd16269   180 EAEAEAILQADQALTEKEKEIEAERAKAEAAEQERKLLEEQQ----RELEQKLEDQERSYEEhlRQLKEKME--EERENL 253
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 254675251 2291 KAEAELLQQQKElaQEQARRLQEDKEQMAQQLVEETQGFQ 2330
Cdd:cd16269   254 LKEQERALESKL--KEQEALLEEGFKEQAELLQEEIRSLK 291
PLEC smart00250
Plectin repeat;
2981-3018 5.15e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.16  E-value: 5.15e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 254675251   2981 RQALRGTNVIAGVWLEEAGQKLSIYEALKKDLLQPEVA 3018
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PLEC smart00250
Plectin repeat;
2654-2690 5.30e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.16  E-value: 5.30e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   2654 RYLKGRSSIAGLLLKPTNEKLSVYTALQRQLLSPGTA 2690
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
1364-1848 6.98e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 411407 [Multi-domain]  Cd Length: 684  Bit Score: 45.77  E-value: 6.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1364 EEVARREEAAVDAQQQK--RSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEG-EL 1440
Cdd:NF033838   53 NESQKEHAKEVESHLEKilSEIQKSLDKRKHTQNVALNKKLSDIKTEYLYELNVLKEKSEAELTSKTKKELDAAFEQfKK 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1441 QALRARAEEAEAQK------RQAQEEAERLRRQVQDESQRKRQAE-AELALRVKaEAEAAREKQRALQALDELRLQAEEA 1513
Cdd:NF033838  133 DTLEPGKKVAEATKkveeaeKKAKDQKEEDRRNYPTNTYKTLELEiAESDVEVK-KAELELVKEEAKEPRDEEKIKQAKA 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1514 ERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKtaqlertlqeehvtvaqlreeaerraqqqaeaerareeae 1593
Cdd:NF033838  212 KVESKKAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEK---------------------------------------- 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1594 relerwqlkaNEALRLRLQAEEVAQQKSLAQADAEKQKEEAErearrrgKAEEQAVRQRELAEQELEKQRQLAEgtAQQR 1673
Cdd:NF033838  252 ----------NVATSEQDKPKRRAKRGVLGEPATPDKKENDA-------KSSDSSVGEETLPSPSLKPEKKVAE--AEKK 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1674 LAAEQElirlRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEmevllasKARAEEESRSTSEKSKQR 1753
Cdd:NF033838  313 VEEAKK----KAKDQKEEDRRNYPTNTYKTLELEIAESDVKVKEAELELVKEEAK-------EPRNEEKIKQAKAKVESK 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1754 LeAEAGRFrelaeeaarlralaEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRR 1833
Cdd:NF033838  382 K-AEATRL--------------EKIKTDRKKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPAEQPKAEK 446
                         490
                  ....*....|....*..
gi 254675251 1834 LAEDEAFQ--RRRLEEQ 1848
Cdd:NF033838  447 PADQQAEEdyARRSEEE 463
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
1317-1418 8.94e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 44.49  E-value: 8.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1317 EQQRAEERERLAEVEAALEKQRQLAEAHAQAkaqaelEAQELQRRMQEEVARREEaaVDAQQQKRSIQEELQHLRQSSEA 1396
Cdd:cd16269   177 QSKEAEAEAILQADQALTEKEKEIEAERAKA------EAAEQERKLLEEQQRELE--QKLEDQERSYEEHLRQLKEKMEE 248
                          90       100
                  ....*....|....*....|..
gi 254675251 1397 EIQAKAQQVEAAERSRMRIEEE 1418
Cdd:cd16269   249 ERENLLKEQERALESKLKEQEA 270
PLEC smart00250
Plectin repeat;
3021-3054 9.85e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 39.39  E-value: 9.85e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 254675251   3021 LLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3054
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
PLEC smart00250
Plectin repeat;
2730-2766 2.06e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 38.62  E-value: 2.06e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   2730 KLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVRDHG 2766
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
2984-3021 2.09e-03

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 38.47  E-value: 2.09e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 254675251  2984 LRGTNVIAGVWLEEAGQKLSIYEALKKDLLQPEVAVAL 3021
Cdd:pfam00681    2 LEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
SPEC smart00150
Spectrin repeats;
487-581 2.88e-03

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 40.01  E-value: 2.88e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    487 LRYLQDLLAWVEENQRRIDSAEWGVDLPSVEAQLGSHRGMHQSIEEFRAKIERARNDESQL---SPATRGAYRDCLGRLD 563
Cdd:smart00150    4 LRDADELEAWLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLieeGHPDAEEIEERLEELN 83
                            90
                    ....*....|....*...
gi 254675251    564 LQYAKLLNSSKARLRSLE 581
Cdd:smart00150   84 ERWEELKELAEERRQKLE 101
PLEC smart00250
Plectin repeat;
3389-3420 4.95e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.46  E-value: 4.95e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 254675251   3389 KLLSAEKAVTGYKDPYSGNTISLFQAMKKGLV 3420
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLI 33
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4245-4275 7.08e-03

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 36.93  E-value: 7.08e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 254675251  4245 AGILDTETLEKVSITEAMHRNLVDNITGQRL 4275
Cdd:pfam00681    9 GGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
 
Name Accession Description Interval E-value
CH_PLEC-like_rpt1 cd21188
first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family; This family ...
9-113 7.17e-76

first calponin homology (CH) domain found in the plectin/dystonin/MACF1 family; This family includes plectin, dystonin and microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1). Plectin, also called PCN, PLTN, hemidesmosomal protein 1 (HD1), or plectin-1, is a structural component of muscle. It interlinks intermediate filaments with microtubules and microfilaments, and anchors intermediate filaments to desmosomes or hemidesmosomes. It could also bind muscle proteins such as actin to membrane complexes in muscle. Dystonin, also called 230 kDa bullous pemphigoid antigen, 230/240 kDa bullous pemphigoid antigen, bullous pemphigoid antigen 1 (BPA or BPAG1), dystonia musculorum protein, or hemidesmosomal plaque protein, is a cytoskeletal linker protein that acts as an integrator of intermediate filaments, actin, and microtubule cytoskeleton networks. It is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells, or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. MACF1, also called 620 kDa actin-binding protein (ABP620), actin cross-linking family protein 7 (ACF7), macrophin-1, or trabeculin-alpha, is a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. It facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Members of this family contain two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409037  Cd Length: 105  Bit Score: 247.31  E-value: 7.17e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    9 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNI 88
Cdd:cd21188     1 DAVQKKTFTKWVNKHLIKARRRVVDLFEDLRDGHNLISLLEVLSGESLPRERGRMRFHRLQNVQTALDFLKYRKIKLVNI 80
                          90       100
                  ....*....|....*....|....*
gi 254675251   89 RNDDIADGNPKLTLGLIWTIILHFQ 113
Cdd:cd21188    81 RAEDIVDGNPKLTLGLIWTIILHFQ 105
CH_PLEC_rpt1 cd21235
first calponin homology (CH) domain found in plectin and similar proteins; Plectin, also ...
6-124 2.77e-73

first calponin homology (CH) domain found in plectin and similar proteins; Plectin, also called PCN, PLTN, hemidesmosomal protein 1 (HD1), or plectin-1, is a structural component of muscle. It interlinks intermediate filaments with microtubules and microfilaments, and anchors intermediate filaments to desmosomes or hemidesmosomes. It can also bind muscle proteins such as actin to membrane complexes in muscle. Plectin contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409084  Cd Length: 119  Bit Score: 240.70  E-value: 2.77e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    6 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKL 85
Cdd:cd21235     1 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKL 80
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 254675251   86 VNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSE 124
Cdd:cd21235    81 VNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQSE 119
CH_PLEC_rpt2 cd21238
second calponin homology (CH) domain found in plectin and similar proteins; Plectin, also ...
126-231 8.68e-72

second calponin homology (CH) domain found in plectin and similar proteins; Plectin, also called PCN, PLTN, hemidesmosomal protein 1 (HD1), or plectin-1, is a structural component of muscle. It interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. It can also bind muscle proteins such as actin to membrane complexes in muscle. Plectin contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409087  Cd Length: 106  Bit Score: 236.07  E-value: 8.68e-72
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  126 MTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 205
Cdd:cd21238     1 MTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 80
                          90       100
                  ....*....|....*....|....*.
gi 254675251  206 PEDVDVPQPDEKSIITYVSSLYDAMP 231
Cdd:cd21238    81 PEDVDVPQPDEKSIITYVSSLYDAMP 106
CH_DYST_rpt1 cd21236
first calponin homology (CH) domain found in dystonin and similar proteins; Dystonin, also ...
6-122 2.64e-71

first calponin homology (CH) domain found in dystonin and similar proteins; Dystonin, also called 230 kDa bullous pemphigoid antigen, 230/240 kDa bullous pemphigoid antigen, bullous pemphigoid antigen 1 (BPA or BPAG1), dystonia musculorum protein, or hemidesmosomal plaque protein, is a cytoskeletal linker protein that acts as an integrator of intermediate filaments, actin, and microtubule cytoskeleton networks. It is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells, or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. Dystonin contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409085  Cd Length: 128  Bit Score: 235.26  E-value: 2.64e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    6 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKL 85
Cdd:cd21236    12 DERDKVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPREKGRMRFHRLQNVQIALDYLKRRQVKL 91
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 254675251   86 VNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQ 122
Cdd:cd21236    92 VNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGE 128
CH_PLEC-like_rpt2 cd21189
second calponin homology (CH) domain found in the plectin/dystonin/MACF1 family; This family ...
127-231 1.02e-65

second calponin homology (CH) domain found in the plectin/dystonin/MACF1 family; This family includes plectin, dystonin and microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1). Plectin, also called PCN, PLTN, hemidesmosomal protein 1 (HD1), or plectin-1, is a structural component of muscle. It interlinks intermediate filaments with microtubules and microfilaments, and anchors intermediate filaments to desmosomes or hemidesmosomes. It could also bind muscle proteins such as actin to membrane complexes in muscle. Dystonin, also called 230 kDa bullous pemphigoid antigen, 230/240 kDa bullous pemphigoid antigen, bullous pemphigoid antigen 1 (BPA or BPAG1), dystonia musculorum protein, or hemidesmosomal plaque protein, is a cytoskeletal linker protein that acts as an integrator of intermediate filaments, actin, and microtubule cytoskeleton networks. It is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells, or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. MACF1, also called 620 kDa actin-binding protein (ABP620), actin cross-linking family protein 7 (ACF7), macrophin-1, or trabeculin-alpha, is a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. It facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409038  Cd Length: 105  Bit Score: 218.41  E-value: 1.02e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDP 206
Cdd:cd21189     1 SAKEALLLWARRTTEGYPGVRVTNFTSSWRDGLAFNAIIHRNRPDLIDFRSVRNQSNRENLENAFNVAEKEFGVTRLLDP 80
                          90       100
                  ....*....|....*....|....*
gi 254675251  207 EDVDVPQPDEKSIITYVSSLYDAMP 231
Cdd:cd21189    81 EDVDVPEPDEKSIITYVSSLYDVFP 105
CH_MACF1_rpt1 cd21237
first calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, ...
6-123 7.21e-63

first calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins; MACF1, also called 620 kDa actin-binding protein (ABP620), actin cross-linking family protein 7 (ACF7), macrophin-1, or trabeculin-alpha, is a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. It facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. MACF1 contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409086  Cd Length: 118  Bit Score: 211.04  E-value: 7.21e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    6 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKL 85
Cdd:cd21237     1 DERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGVKLPREKGRMRFHRLQNVQIALDFLKQRQVKL 80
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 254675251   86 VNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVSGQS 123
Cdd:cd21237    81 VNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGES 118
CH_DYST_rpt2 cd21239
second calponin homology (CH) domain found in dystonin and similar proteins; Dystonin, also ...
127-231 9.10e-58

second calponin homology (CH) domain found in dystonin and similar proteins; Dystonin, also called 230 kDa bullous pemphigoid antigen, 230/240 kDa bullous pemphigoid antigen, bullous pemphigoid antigen 1 (BPA or BPAG1), dystonia musculorum protein, or hemidesmosomal plaque protein, is a cytoskeletal linker protein that acts as an integrator of intermediate filaments, actin, and microtubule cytoskeleton networks. It is required for anchoring either intermediate filaments to the actin cytoskeleton in neural and muscle cells, or keratin-containing intermediate filaments to hemidesmosomes in epithelial cells. Dystonin contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409088  Cd Length: 104  Bit Score: 195.59  E-value: 9.10e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERdLGVTRLLDP 206
Cdd:cd21239     1 SAKERLLLWSQQMTEGYTGIRCENFTTCWRDGRLFNAIIHKYRPDLIDMNTVAVQSNLANLEHAFYVAEK-LGVTRLLDP 79
                          90       100
                  ....*....|....*....|....*
gi 254675251  207 EDVDVPQPDEKSIITYVSSLYDAMP 231
Cdd:cd21239    80 EDVDVSSPDEKSVITYVSSLYDVFP 104
CH_MACF1_rpt2 cd21240
second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, ...
125-231 4.89e-51

second calponin homology (CH) domain found in microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 (MACF1) and similar proteins; MACF1, also called 620 kDa actin-binding protein (ABP620), actin cross-linking family protein 7 (ACF7), macrophin-1, or trabeculin-alpha, is a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. It facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. MACF1 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409089  Cd Length: 107  Bit Score: 176.77  E-value: 4.89e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  125 DMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERdLGVTRLL 204
Cdd:cd21240     2 DMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAER-LGVTRLL 80
                          90       100
                  ....*....|....*....|....*..
gi 254675251  205 DPEDVDVPQPDEKSIITYVSSLYDAMP 231
Cdd:cd21240    81 DAEDVDVPSPDEKSVITYVSSIYDAFP 107
CH_DMD-like_rpt1 cd21186
first calponin homology (CH) domain found in the dystrophin family; The dystrophin family ...
11-114 1.14e-50

first calponin homology (CH) domain found in the dystrophin family; The dystrophin family includes dystrophin and its paralog, utrophin. Dystrophin, encoded by the DMD gene, is a large, submembrane cytoskeletal protein that is the main component of the dystrophin-glycoprotein complex (DGC) in skeletal muscles. It links the transmembrane DGC to the actin cytoskeleton through binding strongly to the cytoplasmic tail of beta-dystroglycan, the transmembrane subunit of a highly O-glycosylated cell-surface protein. Dystrophin is also involved in maintaining the structural integrity of cells, as well as in the formation of the blood-brain barrier (BBB). Utrophin, also called dystrophin-related protein 1 (DRP-1), is an autosomal dystrophin homolog that increases dystrophic muscle function and reduces pathology. It is broadly expressed in both the mRNA and protein levels, and occurs in the cerebrovascular endothelium. Utrophin forms the utrophin-glycoprotein complex (UGC) by interacting with dystroglycans (DGs) and sarcoglycan-dystroglycans, as well as sarcoglycan and sarcospan (SG-SSPN) subcomplexes. It may act as a scaffolding protein that stabilizes lipid microdomains and clusters mechanosensitive channel subunits, and links the F-actin cytoskeleton to the cell membrane via the associated glycoprotein complex. Members of this family contain two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409035  Cd Length: 107  Bit Score: 175.65  E-value: 1.14e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   11 VQKKTFTKWVNKHLIKAQR-HISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIR 89
Cdd:cd21186     2 VQKKTFTKWINSQLSKANKpPIKDLFEDLRDGTRLLALLEVLTGKKLKPEKGRMRVHHLNNVNRALQVLEQNNVKLVNIS 81
                          90       100
                  ....*....|....*....|....*
gi 254675251   90 NDDIADGNPKLTLGLIWTIILHFQI 114
Cdd:cd21186    82 SNDIVDGNPKLTLGLVWSIILHWQV 106
CH_SPTB-like_rpt1 cd21246
first calponin homology (CH) domain found in the beta-I spectrin-like subfamily; The beta-I ...
2-110 1.09e-47

first calponin homology (CH) domain found in the beta-I spectrin-like subfamily; The beta-I spectrin-like family includes beta-I, -II, -III and -IV spectrins. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. Beta-I spectrin, also called spectrin beta chain, erythrocytic (SPTB), may be involved in anaemia pathogenesis. Beta-II spectrin, also called spectrin beta chain, non-erythrocytic 1 (SPTBN1), or fodrin beta chain, is a component of fodrin, which is the general spectrin-like protein that seems to be involved in secretion. Fodrin interacts with calmodulin in a calcium-dependent manner and is thus a candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Beta-III spectrin, also called spectrin beta chain, non-erythrocytic 2 (SPTBN2), or spinocerebellar ataxia 5 protein (SCA5), may play a crucial role as a longer actin-membrane cross-linker or fulfill the need for greater extensible flexibility than can be provided by the other smaller conventional spectrins. Beta-IV spectrin is also called spectrin, non-erythroid beta chain 3 (SPTBN3) or spectrin beta chain, non-erythrocytic 4 (SPTBN4). Its mutation associates with congenital myopathy, neuropathy, and central deafness. Members of this subfamily contain two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409095  Cd Length: 117  Bit Score: 167.54  E-value: 1.09e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    2 KIVPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHKLQNVQIALDYLRH 80
Cdd:cd21246     7 KALADEREAVQKKTFTKWVNSHLARVGCRINDLYTDLRDGRMLIKLLEVLSGERLPKpTKGKMRIHCLENVDKALQFLKE 86
                          90       100       110
                  ....*....|....*....|....*....|
gi 254675251   81 RQVKLVNIRNDDIADGNPKLTLGLIWTIIL 110
Cdd:cd21246    87 QRVHLENMGSHDIVDGNHRLTLGLIWTIIL 116
CH_beta_spectrin_rpt2 cd21194
second calponin homology (CH) domain found in the beta spectrin family; The beta spectrin ...
127-227 2.35e-46

second calponin homology (CH) domain found in the beta spectrin family; The beta spectrin family includes beta-I, -II, -III, -IV and -V spectrins. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. Beta-I spectrin, also called spectrin beta chain, erythrocytic (SPTB), may be involved in anaemia pathogenesis. Beta-II spectrin, also called spectrin beta chain, non-erythrocytic 1 (SPTBN1), or fodrin beta chain, is a component of fodrin, which is the general spectrin-like protein that seems to be involved in secretion. Fodrin interacts with calmodulin in a calcium-dependent manner and is thus a candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Beta-IV spectrin is also called spectrin, non-erythroid beta chain 3 (SPTBN3) or spectrin beta chain, non-erythrocytic 4 (SPTBN4). Its mutation associates with congenital myopathy, neuropathy, and central deafness. Beta-III spectrin is also called spectrin beta chain, non-erythrocytic 2 (SPTBN2), or spinocerebellar ataxia 5 protein (SCA5). Beta-V spectrin, also called spectrin beta chain, non-erythrocytic 5 (SPTBN5), is a mammalian ortholog of Drosophila beta H spectrin. Beta-III and Beta-V spectrins may play crucial roles as longer actin-membrane cross-linkers or fulfill the need for greater extensible flexibility than can be provided by the other smaller conventional spectrins. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409043  Cd Length: 105  Bit Score: 162.97  E-value: 2.35e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDP 206
Cdd:cd21194     2 SAKDALLLWCQRKTAGYPGVNIQNFTTSWRDGLAFNALIHAHRPDLIDYNRLDPNDHLGNLNNAFDVAEQELGIAKLLDA 81
                          90       100
                  ....*....|....*....|.
gi 254675251  207 EDVDVPQPDEKSIITYVSSLY 227
Cdd:cd21194    82 EDVDVARPDEKSIMTYVASYY 102
SAC6 COG5069
Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton];
10-338 3.44e-45

Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton];


Pssm-ID: 227401 [Multi-domain]  Cd Length: 612  Bit Score: 175.90  E-value: 3.44e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   10 RVQKKTFTKWVNKHLIKA-QRHISDLYEDLRDGHNLISLLEVLSGDSLPR--EKGRMRFHKLQNVQIALDYLRHRQVKLV 86
Cdd:COG5069     8 KVQKKTFTKWTNEKLISGgQKEFGDLDTDLKDGVKLAQLLEALQKDNAGEynETPETRIHVMENVSGRLEFIKGKGVKLF 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   87 NIRNDDIADGNPKLTLGLIWTIILHFQISDIQvsgQSEDMTAKEKLLLWSQRMVEGYQ-GLRCDNFTTSWRDGRLFNAII 165
Cdd:COG5069    88 NIGPQDIVDGNPKLILGLIWSLISRLTIATIN---EEGELTKHINLLLWCDEDTGGYKpEVDTFDFFRSWRDGLAFSALI 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  166 HRHKPMLIDMNKVYRQTNLE--NLDQAFSVAERDLGVTRLLDPEDV-DVPQPDEKSIITYVS------SLYD----AMPR 232
Cdd:COG5069   165 HDSRPDTLDPNVLDLQKKNKalNNFQAFENANKVIGIARLIGVEDIvNVSIPDERSIMTYVSwyiirfGLLEkidiALHR 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  233 VPGAQDGVRANElQLRwQEYRELVLLLLQWIRHHTAAFEERKFPSSFEEIEILWCQFLKFKETE--LPAKEAD-KNRSKV 309
Cdd:COG5069   245 VYRLLEADETLI-QLR-LPYEIILLRLLNLIHLKQANWKVVNFSKDVSDGENYTDLLNQLNALCsrAPLETTDlHSLAGQ 322
                         330       340
                  ....*....|....*....|....*....
gi 254675251  310 IYQSLEgAVQAGQLKIPPGYHPLDVEKEW 338
Cdd:COG5069   323 ILQNAE-KYDCRKYLPPAGNPKLDLAFVA 350
CH_SPTB_like_rpt2 cd21248
second calponin homology (CH) domain found in the beta-I spectrin-like subfamily; The beta-I ...
127-227 1.73e-44

second calponin homology (CH) domain found in the beta-I spectrin-like subfamily; The beta-I spectrin-like family includes beta-I, -II, -III and -IV spectrins. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. Beta-I spectrin, also called spectrin beta chain, erythrocytic (SPTB), may be involved in anaemia pathogenesis. Beta-II spectrin, also called spectrin beta chain, non-erythrocytic 1 (SPTBN1), or fodrin beta chain, is a component of fodrin, which is the general spectrin-like protein that seems to be involved in secretion. Fodrin interacts with calmodulin in a calcium-dependent manner and is thus a candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Beta-III spectrin, also called spectrin beta chain, non-erythrocytic 2 (SPTBN2), or spinocerebellar ataxia 5 protein (SCA5), may play a crucial role as a longer actin-membrane cross-linker or fulfill the need for greater extensible flexibility than can be provided by the other smaller conventional spectrins. Beta-IV spectrin is also called spectrin, non-erythroid beta chain 3 (SPTBN3) or spectrin beta chain, non-erythrocytic 4 (SPTBN4). Its mutation associates with congenital myopathy, neuropathy, and central deafness. Members of this subfamily contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409097  Cd Length: 105  Bit Score: 157.94  E-value: 1.73e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDP 206
Cdd:cd21248     2 SAKDALLLWCQMKTAGYPNVNVRNFTTSWRDGLAFNALIHKHRPDLIDYDKLSKSNALYNLQNAFNVAEQKLGLTKLLDP 81
                          90       100
                  ....*....|....*....|.
gi 254675251  207 EDVDVPQPDEKSIITYVSSLY 227
Cdd:cd21248    82 EDVNVEQPDEKSIITYVVTYY 102
CH_SYNE1_rpt1 cd21241
first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar ...
7-114 4.83e-44

first calponin homology (CH) domain found in synaptic nuclear envelope protein 1 and similar proteins; Synaptic nuclear envelope protein 1 (SYNE-1), also called nesprin-1, enaptin, KASH domain-containing protein 1 (KASH1), myocyte nuclear envelope protein 1 (MYNE-1), or nuclear envelope spectrin repeat protein 1, is a multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain subcellular spatial organization. SYNE-1 also acts as a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, which is involved in the connection between the nuclear lamina and the cytoskeleton. SYNE-1 contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409090  Cd Length: 113  Bit Score: 156.77  E-value: 4.83e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    7 ERDRVQKKTFTKWVNKHLIKAQR--HISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM--RFHKLQNVQIALDYLRHRQ 82
Cdd:cd21241     1 EQERVQKKTFTNWINSYLAKRKPpmKVEDLFEDIKDGTKLLALLEVLSGEKLPCEKGRRlkRVHFLSNINTALKFLESKK 80
                          90       100       110
                  ....*....|....*....|....*....|..
gi 254675251   83 VKLVNIRNDDIADGNPKLTLGLIWTIILHFQI 114
Cdd:cd21241    81 IKLVNINPTDIVDGKPSIVLGLIWTIILYFQI 112
CH_beta_spectrin_rpt1 cd21193
first calponin homology (CH) domain found in the beta spectrin family; The beta spectrin ...
6-110 1.54e-43

first calponin homology (CH) domain found in the beta spectrin family; The beta spectrin family includes beta-I, -II, -III, -IV and -V spectrins. Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. Beta-I spectrin, also called spectrin beta chain, erythrocytic (SPTB), may be involved in anaemia pathogenesis. Beta-II spectrin, also called spectrin beta chain, non-erythrocytic 1 (SPTBN1), or fodrin beta chain, is a component of fodrin, which is the general spectrin-like protein that seems to be involved in secretion. Fodrin interacts with calmodulin in a calcium-dependent manner and is thus a candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Beta-IV spectrin is also called spectrin, non-erythroid beta chain 3 (SPTBN3) or spectrin beta chain, non-erythrocytic 4 (SPTBN4). Its mutation associates with congenital myopathy, neuropathy, and central deafness. Beta-III spectrin is also called spectrin beta chain, non-erythrocytic 2 (SPTBN2), or spinocerebellar ataxia 5 protein (SCA5). Beta-V spectrin, also called spectrin beta chain, non-erythrocytic 5 (SPTBN5), is a mammalian ortholog of Drosophila beta H spectrin. Beta-III and Beta-V spectrins may play crucial roles as longer actin-membrane cross-linkers or fulfill the need for greater extensible flexibility than can be provided by the other smaller conventional spectrins. Members of this family contain two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409042  Cd Length: 116  Bit Score: 155.53  E-value: 1.54e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    6 DERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHKLQNVQIALDYLrHRQVK 84
Cdd:cd21193    11 EERINIQKKTFTKWINSFLEKANLEIGDLFTDLSDGKLLLKLLEIISGEKLGKpNRGRLRVQKIENVNKALAFL-KTKVR 89
                          90       100
                  ....*....|....*....|....*.
gi 254675251   85 LVNIRNDDIADGNPKLTLGLIWTIIL 110
Cdd:cd21193    90 LENIGAEDIVDGNPRLILGLIWTIIL 115
CH_SYNE-like_rpt1 cd21190
first calponin homology (CH) domain found in the synaptic nuclear envelope protein family; The ...
7-114 2.11e-43

first calponin homology (CH) domain found in the synaptic nuclear envelope protein family; The synaptic nuclear envelope (SYNE) family includes SYNE-1, -2 and calmin. SYNE-1 (also called nesprin-1, enaptin, KASH domain-containing protein 1, KASH1, myocyte nuclear envelope protein 1, MYNE-1, or nuclear envelope spectrin repeat protein 1) and SYNE-2 (also called nesprin-2, KASH domain-containing protein 2, KASH2, nuclear envelope spectrin repeat protein 2, nucleus and actin connecting element protein, or protein NUANCE) may act redundantly. They are multi-isomeric modular proteins which form a linking network between organelles and the actin cytoskeleton to maintain subcellular spatial organization. They also act as components of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, which is involved in the connection between the nuclear lamina and the cytoskeleton. Calmin, also called calponin-like transmembrane domain protein, is a protein with calponin homology (CH) and transmembrane domains expressed in maturing spermatogenic cells. It may be involved in the development and/or maintenance of neuronal functions. Members of this family contain two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409039  Cd Length: 113  Bit Score: 155.04  E-value: 2.11e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    7 ERDRVQKKTFTKWVNKHLikaQRH-----ISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM--RFHKLQNVQIALDYLR 79
Cdd:cd21190     1 EQERVQKKTFTNWINSHL---AKLsqpivINDLFVDIKDGTALLRLLEVLSGQKLPIESGRVlqRAHKLSNIRNALDFLT 77
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 254675251   80 HRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI 114
Cdd:cd21190    78 KRCIKLVNINSTDIVDGKPSIVLGLIWTIILYFQI 112
CH_ACTN_rpt2 cd21216
second calponin homology (CH) domain found in the alpha-actinin family; The alpha-actinin ...
114-229 2.84e-41

second calponin homology (CH) domain found in the alpha-actinin family; The alpha-actinin (ACTN) family includes alpha-actinin-1, -2, -3, and -4. They are F-actin cross-linking proteins which are thought to anchor actin to a variety of intracellular structures. ACTN1 mutations cause congenital macrothrombocytopenia. ACTN2 mutations are associated with cardiomyopathies, as well as skeletal muscle disorder. ACTN3 is critical in anchoring the myofibrillar actin filaments and plays a key role in muscle contraction. ACTN4 is associated with cell motility and cancer invasion. It is probably involved in vesicular trafficking via its association with the CART complex, which is necessary for efficient transferrin receptor recycling but not for epidermal growth factor receptor (EGFR) degradation. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409065  Cd Length: 115  Bit Score: 149.05  E-value: 2.84e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  114 ISDIQVsgqsEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSV 193
Cdd:cd21216     1 IQDISV----EELSAKEGLLLWCQRKTAPYKNVNVQNFHTSWKDGLAFCALIHRHRPDLLDYDKLRKDDPRENLNLAFDV 76
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 254675251  194 AERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDA 229
Cdd:cd21216    77 AEKHLDIPKMLDAEDiVNTPRPDERSVMTYVSCYYHA 113
CH_SYNE1_rpt2 cd21243
second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and ...
126-231 6.64e-41

second calponin homology (CH) domain found in synaptic nuclear envelope protein 1 (SYNE-1) and similar proteins; SYNE-1, also called nesprin-1, enaptin, KASH domain-containing protein 1 (KASH1), myocyte nuclear envelope protein 1 (MYNE-1), or nuclear envelope spectrin repeat protein 1, is a multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain subcellular spatial organization. SYNE-1 also acts as a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, which is involved in the connection between the nuclear lamina and the cytoskeleton. SYNE-1 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409092  Cd Length: 109  Bit Score: 147.85  E-value: 6.64e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  126 MTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 205
Cdd:cd21243     4 GGAKKALLKWVQNAAAKRFGIEVKDFGPSWRDGVAFNAIIHSIRPDLVDMESLKRRSNRENLETAFTVAEKELGIPRLLD 83
                          90       100
                  ....*....|....*....|....*.
gi 254675251  206 PEDVDVPQPDEKSIITYVSSLYDAMP 231
Cdd:cd21243    84 PEDVDVDKPDEKSIMTYVAQFLKKYP 109
CH_SPTBN4_rpt1 cd21318
first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 4 (SPTBN4) ...
1-110 1.65e-40

first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 4 (SPTBN4) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTBN4, also called beta-IV spectrin, or spectrin, non-erythroid beta chain 3 (SPTBN3), is a novel spectrin isolated as an interactor of the receptor tyrosine phosphatase-like protein ICA512. Its mutation associates with congenital myopathy, neuropathy, and central deafness. SPTBN4 contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409167  Cd Length: 139  Bit Score: 147.86  E-value: 1.65e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    1 MKIVPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHKLQNVQIALDYLR 79
Cdd:cd21318    28 IKALADEREAVQKKTFTKWVNSHLARVPCRINDLYTDLRDGYVLTRLLEVLSGEQLPKpTRGRMRIHSLENVDKALQFLK 107
                          90       100       110
                  ....*....|....*....|....*....|.
gi 254675251   80 HRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 110
Cdd:cd21318   108 EQRVHLENVGSHDIVDGNHRLTLGLIWTIIL 138
CH_SPTBN2_rpt1 cd21317
first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) ...
1-110 2.68e-39

first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTBN2, also called beta-III spectrin, or spinocerebellar ataxia 5 protein (SCA5), probably plays an important role in the neuronal membrane skeleton. Mutations in SPTBN2 is associated with spinocerebellar ataxia type 5. SPTBN2 contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409166  Cd Length: 132  Bit Score: 144.04  E-value: 2.68e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    1 MKIVPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHKLQNVQIALDYLR 79
Cdd:cd21317    21 IKALADEREAVQKKTFTKWVNSHLARVTCRIGDLYTDLRDGRMLIRLLEVLSGEQLPKpTKGRMRIHCLENVDKALQFLK 100
                          90       100       110
                  ....*....|....*....|....*....|.
gi 254675251   80 HRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 110
Cdd:cd21317   101 EQKVHLENMGSHDIVDGNHRLTLGLIWTIIL 131
CH_SPTBN2_rpt2 cd21321
second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) ...
123-227 1.53e-38

second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 2 (SPTBN2) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTBN2, also called beta-III spectrin, or spinocerebellar ataxia 5 protein (SCA5), probably plays an important role in the neuronal membrane skeleton. Mutations in SPTBN2 is associated with spinocerebellar ataxia type 5. SPTBN2 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409170  Cd Length: 119  Bit Score: 141.35  E-value: 1.53e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  123 SEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTR 202
Cdd:cd21321     1 KEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHRPDLIDFETLKKSNAHYNLQNAFNVAEKELGLTK 80
                          90       100
                  ....*....|....*....|....*
gi 254675251  203 LLDPEDVDVPQPDEKSIITYVSSLY 227
Cdd:cd21321    81 LLDPEDVNVDQPDEKSIITYVATYY 105
CH_SpAIN1-like_rpt1 cd21215
first calponin homology (CH) domain found in Schizosaccharomyces pombe alpha-actinin-like ...
11-112 1.80e-38

first calponin homology (CH) domain found in Schizosaccharomyces pombe alpha-actinin-like protein 1 and similar proteins; Schizosaccharomyces pombe alpha-actinin-like protein 1 (SpAIN1) binds to actin and is involved in actin-ring formation and organization. It plays a role in cytokinesis and is involved in septation. Members of this family contain two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409064  Cd Length: 107  Bit Score: 140.61  E-value: 1.80e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   11 VQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR--EKGRMRFHKLQNVQIALDYLRHRQVKLVNI 88
Cdd:cd21215     4 VQKKTFTKWLNTKLSSRGLSITDLVTDLSDGVRLIQLLEIIGDESLGRynKNPKMRVQKLENVNKALEFIKSRGVKLTNI 83
                          90       100
                  ....*....|....*....|....
gi 254675251   89 RNDDIADGNPKLTLGLIWTIILHF 112
Cdd:cd21215    84 GAEDIVDGNLKLILGLLWTLILRF 107
CH_ACTN_rpt1 cd21214
first calponin homology (CH) domain found in the alpha-actinin family; The alpha-actinin (ACTN) ...
9-110 2.19e-38

first calponin homology (CH) domain found in the alpha-actinin family; The alpha-actinin (ACTN) family includes alpha-actinin-1, -2, -3, and -4. They are F-actin cross-linking proteins which are thought to anchor actin to a variety of intracellular structures. ACTN1 mutations cause congenital macrothrombocytopenia. ACTN2 mutations are associated with cardiomyopathies, as well as skeletal muscle disorder. ACTN3 is critical in anchoring the myofibrillar actin filaments and plays a key role in muscle contraction. ACTN4 is associated with cell motility and cancer invasion. It is probably involved in vesicular trafficking via its association with the CART complex, which is necessary for efficient transferrin receptor recycling but not for epidermal growth factor receptor (EGFR) degradation. Members of this family contain two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409063  Cd Length: 105  Bit Score: 140.22  E-value: 2.19e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    9 DRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHKLQNVQIALDYLRHRQVKLVN 87
Cdd:cd21214     3 EKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLPKpERGKMRFHKIANVNKALDFIASKGVKLVS 82
                          90       100
                  ....*....|....*....|...
gi 254675251   88 IRNDDIADGNPKLTLGLIWTIIL 110
Cdd:cd21214    83 IGAEEIVDGNLKMTLGMIWTIIL 105
CH_SYNE2_rpt1 cd21242
first calponin homology (CH) domain found in synaptic nuclear envelope protein 2; Synaptic ...
7-114 2.56e-38

first calponin homology (CH) domain found in synaptic nuclear envelope protein 2; Synaptic nuclear envelope protein 2 (SYNE-2), also called nesprin-2, KASH domain-containing protein 2 (KASH2), nuclear envelope spectrin repeat protein 2, nucleus and actin connecting element protein, or protein NUANCE, is a multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain subcellular spatial organization. SYNE-2 also acts as a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, which is involved in the connection between the nuclear lamina and the cytoskeleton. SYNE-2 contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409091  Cd Length: 111  Bit Score: 140.35  E-value: 2.56e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    7 ERDRVQKKTFTKWVNKHLIKAQ--RHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVK 84
Cdd:cd21242     1 EQEQTQKRTFTNWINSQLAKHSppSVVSDLFTDIQDGHRLLDLLEVLSGQQLPREKGHNVFQCRSNIETALSFLKNKSIK 80
                          90       100       110
                  ....*....|....*....|....*....|
gi 254675251   85 LVNIRNDDIADGNPKLTLGLIWTIILHFQI 114
Cdd:cd21242    81 LINIHVPDIIEGKPSIILGLIWTIILHFHI 110
CH_SPTB_rpt2 cd21319
second calponin homology (CH) domain found in spectrin beta chain, erythrocytic (SPTB) and ...
123-227 2.61e-38

second calponin homology (CH) domain found in spectrin beta chain, erythrocytic (SPTB) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTB, also called beta-I spectrin, may be involved in anaemia pathogenesis. SPTB contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409168  Cd Length: 112  Bit Score: 140.53  E-value: 2.61e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  123 SEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTR 202
Cdd:cd21319     1 RETRSAKDALLLWCQMKTAGYPNVNVTNFTSSWKDGLAFNALIHKHRPDLVDFGKLKKSNARHNLEHAFNVAERQLGITK 80
                          90       100
                  ....*....|....*....|....*
gi 254675251  203 LLDPEDVDVPQPDEKSIITYVSSLY 227
Cdd:cd21319    81 LLDPEDVFTENPDEKSIITYVVAFY 105
CH_SPTBN5_rpt2 cd21249
second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 5 (SPTBN5) ...
126-227 6.38e-37

second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 5 (SPTBN5) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTBN5, also called beta-V spectrin, is a mammalian ortholog of Drosophila beta H spectrin that may play a crucial role as a longer actin-membrane cross-linker or to fulfill the need for greater extensible flexibility than can be provided by the other smaller conventional spectrins. SPTBN5 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409098  Cd Length: 109  Bit Score: 136.15  E-value: 6.38e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  126 MTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 205
Cdd:cd21249     3 RSAKEALLIWCQRKTAGYTNVNVQDFSRSWRDGLAFNALIHAHRPDLIDYGSLRPDRPLYNLANAFLVAEQELGISQLLD 82
                          90       100
                  ....*....|....*....|..
gi 254675251  206 PEDVDVPQPDEKSIITYVSSLY 227
Cdd:cd21249    83 PEDVAVPHPDERSIMTYVSLYY 104
CH_DMD_rpt1 cd21231
first calponin homology (CH) domain found in dystrophin and similar proteins; Dystrophin, ...
6-114 1.72e-36

first calponin homology (CH) domain found in dystrophin and similar proteins; Dystrophin, encoded by the DMD gene, is a large, submembrane cytoskeletal protein that is the main component of the dystrophin-glycoprotein complex (DGC) in skeletal muscles. It links the transmembrane DGC to the actin cytoskeleton through binding strongly to the cytoplasmic tail of beta-dystroglycan, the transmembrane subunit of a highly O-glycosylated cell-surface protein. It is involved in maintaining the structural integrity of cells, as well as in the formation of the blood-brain barrier (BBB). Mutations in dystrophin lead to Duchenne muscular dystrophy (DMD). Moreover, dystrophin deficiency is associated with abnormal cerebral diffusion and perfusion, as well as in acute Trypanosoma cruzi infection. The dystrophin subfamily has been characterized by a compact cluster of domains comprising four EF-hand-like motifs and a ZZ-domain, followed by a looser region with two coiled-coils. These domains are believed to be involved in protein-protein interactions. In addition, dystrophin contains two syntrophin binding sites (SBSs) and a long N-terminal extension that comprises two actin-binding calponin homology (CH) domains, approximately 24 spectrin repeats (SRs) and a WW domain. This model corresponds to the first CH domain.


Pssm-ID: 409080  Cd Length: 111  Bit Score: 135.05  E-value: 1.72e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    6 DERDRVQKKTFTKWVNKHLIKAQR-HISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVK 84
Cdd:cd21231     1 YEREDVQKKTFTKWINAQFAKFGKpPIEDLFTDLQDGRRLLELLEGLTGQKLVKEKGSTRVHALNNVNKALQVLQKNNVD 80
                          90       100       110
                  ....*....|....*....|....*....|
gi 254675251   85 LVNIRNDDIADGNPKLTLGLIWTIILHFQI 114
Cdd:cd21231    81 LVNIGSADIVDGNHKLTLGLIWSIILHWQV 110
PTZ00121 PTZ00121
MAEBL; Provisional
1311-2016 2.52e-36

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 153.37  E-value: 2.52e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1311 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSiqEELQHL 1390
Cdd:PTZ00121 1101 EEAKKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKA--EDAKKA 1178
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1391 RQSSEAEIQAKAQQVEAAERSRmRIEEEIRVVRLQlETTERQRGGAEGELQALRaRAEEAeaqkRQAQEEAERLRRQVQD 1470
Cdd:PTZ00121 1179 EAARKAEEVRKAEELRKAEDAR-KAEAARKAEEER-KAEEARKAEDAKKAEAVK-KAEEA----KKDAEEAKKAEEERNN 1251
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1471 ESQRKRQAEAELALRVKAEAEAAREKQRAlqalDELRlQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASF 1550
Cdd:PTZ00121 1252 EEIRKFEEARMAHFARRQAAIKAEEARKA----DELK-KAEEKKKADEAKKAEEKKKADEAKKKAEEAKKADEAKKKAEE 1326
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1551 AEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRlqAEEVaqqkslAQADAEKQ 1630
Cdd:PTZ00121 1327 AKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKK--AEEK------KKADEAKK 1398
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1631 KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATA 1710
Cdd:PTZ00121 1399 KAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKK 1478
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1711 ATQKRQeleAELAKVRAEmevllASKARAEEESRSTSEKSKqrleAEAGRFRELAEEAARLRAlAEEAKRQRQLAEEDAA 1790
Cdd:PTZ00121 1479 AEEAKK---ADEAKKKAE-----EAKKKADEAKKAAEAKKK----ADEAKKAEEAKKADEAKK-AEEAKKADEAKKAEEK 1545
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1791 RQRAEAERvlTEKLAAISEatrlKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKASESE 1870
Cdd:PTZ00121 1546 KKADELKK--AEELKKAEE----KKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAK 1619
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1871 L--------ERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDtMRSKEQAELEAARQRQLAA 1942
Cdd:PTZ00121 1620 IkaeelkkaEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEE-AKKAEEDEKKAAEALKKEA 1698
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251 1943 EEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2016
Cdd:PTZ00121 1699 EEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEE 1772
CH_DMD-like_rpt2 cd21187
second calponin homology (CH) domain found in the dystrophin family; The dystrophin family ...
130-231 4.56e-36

second calponin homology (CH) domain found in the dystrophin family; The dystrophin family includes dystrophin and its paralog, utrophin. Dystrophin, encoded by the DMD gene, is a large, submembrane cytoskeletal protein that is the main component of the dystrophin-glycoprotein complex (DGC) in skeletal muscles. It links the transmembrane DGC to the actin cytoskeleton through binding strongly to the cytoplasmic tail of beta-dystroglycan, the transmembrane subunit of a highly O-glycosylated cell-surface protein. Dystrophin is also involved in maintaining the structural integrity of cells, as well as in the formation of the blood-brain barrier (BBB). Utrophin, also called dystrophin-related protein 1 (DRP-1), is an autosomal dystrophin homolog that increases dystrophic muscle function and reduces pathology. It is broadly expressed in both the mRNA and protein levels, and occurs in the cerebrovascular endothelium. Utrophin forms the utrophin-glycoprotein complex (UGC) by interacting with dystroglycans (DGs) and sarcoglycan-dystroglycans, as well as sarcoglycan and sarcospan (SG-SSPN) subcomplexes. It may act as a scaffolding protein that stabilizes lipid microdomains and clusters mechanosensitive channel subunits, and link the F-actin cytoskeleton to the cell membrane via the associated glycoprotein complex. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409036  Cd Length: 104  Bit Score: 133.71  E-value: 4.56e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  130 EKLLL-WSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED 208
Cdd:cd21187     2 EKTLLaWCRQSTRGYEQVDVKNFTTSWRDGLAFNALIHRHRPDLFDFDSLVKDSPESRLEHAFTVAHEHLGIEKLLDPED 81
                          90       100
                  ....*....|....*....|...
gi 254675251  209 VDVPQPDEKSIITYVSSLYDAMP 231
Cdd:cd21187    82 VNVEQPDKKSILMYVTSLFQVLP 104
CH_SPTBN4_rpt2 cd21322
second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 4 (SPTBN4) ...
111-227 1.88e-35

second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 4 (SPTBN4) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTBN4, also called beta-IV spectrin, or spectrin, non-erythroid beta chain 3 (SPTBN3), is a novel spectrin isolated as an interactor of the receptor tyrosine phosphatase-like protein ICA512. Its mutation associates with congenital myopathy, neuropathy, and central deafness. SPTBN4 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409171  Cd Length: 130  Bit Score: 132.87  E-value: 1.88e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  111 HFQISDIQVSGQSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQA 190
Cdd:cd21322     1 QIQVIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDLIDFSKLTKSNATYNLQQA 80
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 254675251  191 FSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVSSLY 227
Cdd:cd21322    81 FNTAEQHLGLTKLLDPEDVNMEAPDEKSIITYVVSFY 117
CH_dFLNA-like_rpt1 cd21311
first calponin homology (CH) domain found in Drosophila melanogaster filamin-A (dFLNA) and ...
10-115 1.79e-33

first calponin homology (CH) domain found in Drosophila melanogaster filamin-A (dFLNA) and similar proteins; Drosophila melanogaster filamin-A (dFLNA or dFLN-A), also called actin-binding protein 280 (ABP-280) or filamin-1, is involved in germline ring canal formation. It may tether actin microfilaments within the ovarian ring canal to the cell membrane and contributes to actin microfilament organization. dFLNA contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409160  Cd Length: 124  Bit Score: 127.18  E-value: 1.79e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   10 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGR--MRFHKLQNVQIALDYLRHRQ-VKLV 86
Cdd:cd21311    14 RIQQNTFTRWANEHLKTANKHIADLETDLSDGLRLIALVEVLSGKKFPKFNKRptFRSQKLENVSVALKFLEEDEgIKIV 93
                          90       100
                  ....*....|....*....|....*....
gi 254675251   87 NIRNDDIADGNPKLTLGLIWTIILHFQIS 115
Cdd:cd21311    94 NIDSSDIVDGKLKLILGLIWTLILHYSIS 122
CH_SPTBN1_rpt2 cd21320
second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) ...
127-227 5.09e-33

second calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTBN1, also called beta-II spectrin, fodrin beta chain, or spectrin, non-erythroid beta chain 1, is also a component of fodrin, which is the general spectrin-like protein that seems to be involved in secretion. Fodrin interacts with calmodulin in a calcium-dependent manner and is thus a candidate for the calcium-dependent movement of the cytoskeleton at the membrane. SPTBN1 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409169  Cd Length: 108  Bit Score: 125.21  E-value: 5.09e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDP 206
Cdd:cd21320     2 SAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLIDFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDP 81
                          90       100
                  ....*....|....*....|.
gi 254675251  207 EDVDVPQPDEKSIITYVSSLY 227
Cdd:cd21320    82 EDISVDHPDEKSIITYVVTYY 102
CH_jitterbug-like_rpt1 cd21227
first calponin homology (CH) domain found in Drosophila melanogaster protein jitterbug and ...
11-114 1.57e-32

first calponin homology (CH) domain found in Drosophila melanogaster protein jitterbug and similar proteins; Protein jitterbug (Jbug) is an actin-meshwork organizing protein. It is required to maintain the shape and cell orientation of the Drosophila notum epithelium during flight muscle attachment to tendon cells. Jbug contains three copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409076  Cd Length: 109  Bit Score: 123.55  E-value: 1.57e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   11 VQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR--EKGRMRFHKLQNVQIALDYLRHRQVKLVNI 88
Cdd:cd21227     4 IQKNTFTNWVNEQLKPTGMSVEDLATDLEDGVKLIALVEILQGRKLGRviKKPLNQHQKLENVTLALKAMAEDGIKLVNI 83
                          90       100
                  ....*....|....*....|....*.
gi 254675251   89 RNDDIADGNPKLTLGLIWTIILHFQI 114
Cdd:cd21227    84 GNEDIVNGNLKLILGLIWHLILRYQI 109
CH_UTRN_rpt1 cd21232
first calponin homology (CH) domain found in utrophin and similar proteins; Utrophin, also ...
11-114 1.64e-32

first calponin homology (CH) domain found in utrophin and similar proteins; Utrophin, also called dystrophin-related protein 1 (DRP-1), is an autosomal dystrophin homolog that increases dystrophic muscle function and reduces pathology. It is broadly expressed in both the mRNA and protein levels, and occurs in the cerebrovascular endothelium. Utrophin forms the utrophin-glycoprotein complex (UGC) by interacting with dystroglycans (DGs) and sarcoglycan-dystroglycans, as well as sarcoglycan and sarcospan (SG-SSPN) subcomplexes. It may act as a scaffolding protein that stabilizes lipid microdomains and clusters mechanosensitive channel subunits, and link the F-actin cytoskeleton to the cell membrane via the associated glycoprotein complex. Like dystrophin, utrophin has a compact cluster of domains comprising four EF-hand-like motifs and a ZZ-domain, followed by a looser region with two coiled-coils. These domains are believed to be involved in protein-protein interactions. In addition, it contains two syntrophin binding sites (SBSs) and a long N-terminal extension that comprises two actin-binding calponin homology (CH) domains, up to 24 spectrin repeats (SRs), and a WW domain. However, utrophin lacks the intrinsic microtubule binding activity of dystrophin SRs. This model corresponds to the first CH domain.


Pssm-ID: 409081  Cd Length: 107  Bit Score: 123.58  E-value: 1.64e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   11 VQKKTFTKWVNKHLIKAQR-HISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRFHKLQNVQIALDYLRHRQVKLVNIR 89
Cdd:cd21232     2 VQKKTFTKWINARFSKSGKpPIKDMFTDLRDGRKLLDLLEGLTGKSLPKERGSTRVHALNNVNRVLQVLHQNNVELVNIG 81
                          90       100
                  ....*....|....*....|....*
gi 254675251   90 NDDIADGNPKLTLGLIWTIILHFQI 114
Cdd:cd21232    82 GTDIVDGNHKLTLGLLWSIILHWQV 106
CH_SPTBN1_rpt1 cd21316
first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) ...
1-110 1.89e-32

first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 1 (SPTBN1) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTBN1, also called beta-II spectrin, fodrin beta chain, or spectrin, non-erythroid beta chain 1, is also a component of fodrin, which is the general spectrin-like protein that seems to be involved in secretion. Fodrin interacts with calmodulin in a calcium-dependent manner and is thus a candidate for the calcium-dependent movement of the cytoskeleton at the membrane. SPTBN1 contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409165  Cd Length: 154  Bit Score: 125.16  E-value: 1.89e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    1 MKIVPDERDRVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHKLQNVQIALDYLR 79
Cdd:cd21316    43 IKALADEREAVQKKTFTKWVNSHLARVSCRITDLYMDLRDGRMLIKLLEVLSGERLPKpTKGRMRIHCLENVDKALQFLK 122
                          90       100       110
                  ....*....|....*....|....*....|.
gi 254675251   80 HRQVKLVNIRNDDIADGNPKLTLGLIWTIIL 110
Cdd:cd21316   123 EQRVHLENMGSHDIVDGNHRLTLGLIWTIIL 153
PTZ00121 PTZ00121
MAEBL; Provisional
1304-1925 5.88e-32

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 138.74  E-value: 5.88e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1304 ETLRRMEEEERLAEQQRAEERERLAEVEAALE--KQRQLAEAHAQAKAQAELEAQELQR----RMQEEVARREEAAVDAQ 1377
Cdd:PTZ00121 1161 EDARKAEEARKAEDAKKAEAARKAEEVRKAEElrKAEDARKAEAARKAEEERKAEEARKaedaKKAEAVKKAEEAKKDAE 1240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1378 QQKRSIQE-------ELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRlQLETTERQRGGAEGELQALRAR-AEE 1449
Cdd:PTZ00121 1241 EAKKAEEErnneeirKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKAD-EAKKAEEKKKADEAKKKAEEAKkADE 1319
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1450 AEAQKRQAQEEAERLRRQVQdESQRKRQAEAELALRVKAEAEAAREKQRALQ--------ALDELRLQAEE---AERRLR 1518
Cdd:PTZ00121 1320 AKKKAEEAKKKADAAKKKAE-EAKKAAEAAKAEAEAAADEAEAAEEKAEAAEkkkeeakkKADAAKKKAEEkkkADEAKK 1398
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1519 QAEAERARQVQVALETAQRSAEVELQsKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELER 1598
Cdd:PTZ00121 1399 KAEEDKKKADELKKAAAAKKKADEAK-KKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKK 1477
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1599 WQLKANEALRLRLQAEEVAQqkslaQADAEKQKEEAEREARRRGKAEEqAVRQRELAEQELEKQRQLAEGTAQQRLAAE- 1677
Cdd:PTZ00121 1478 KAEEAKKADEAKKKAEEAKK-----KADEAKKAAEAKKKADEAKKAEE-AKKADEAKKAEEAKKADEAKKAEEKKKADEl 1551
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1678 --QELIRLRAETEQGEQQRQlLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRlE 1755
Cdd:PTZ00121 1552 kkAEELKKAEEKKKAEEAKK-AEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKA-E 1629
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1756 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA--RQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRR 1833
Cdd:PTZ00121 1630 EEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAeeAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKK 1709
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1834 LAEDEAFQRRRLEEQAALHKADIEE--RLAQLRKASESELERQKGlvEDTLRQRRQVEEEIMALKVSFEKAAAGKAELEL 1911
Cdd:PTZ00121 1710 KEAEEKKKAEELKKAEEENKIKAEEakKEAEEDKKKAEEAKKDEE--EKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDE 1787
                         650
                  ....*....|....
gi 254675251 1912 ELGRIRSNAEDTMR 1925
Cdd:PTZ00121 1788 EDEKRRMEVDKKIK 1801
CH_SYNE-like_rpt2 cd21192
second calponin homology (CH) domain found in the synaptic nuclear envelope protein (SYNE) ...
126-224 6.61e-32

second calponin homology (CH) domain found in the synaptic nuclear envelope protein (SYNE) family; The SYNE family includes SYNE-1, -2 and calmin. SYNE-1 (also called nesprin-1, enaptin, KASH domain-containing protein 1, KASH1, myocyte nuclear envelope protein 1, MYNE-1, or nuclear envelope spectrin repeat protein 1) and SYNE-2 (also called nesprin-2, KASH domain-containing protein 2, KASH2, nuclear envelope spectrin repeat protein 2, nucleus and actin connecting element protein, or protein NUANCE) may act redundantly. They are multi-isomeric modular proteins which form a linking network between organelles and the actin cytoskeleton to maintain subcellular spatial organization. They also act as components of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, which is involved in the connection between the nuclear lamina and the cytoskeleton. Calmin, also called calponin-like transmembrane domain protein, is a protein with calponin homology (CH) and transmembrane domains expressed in maturing spermatogenic cells. It may be involved in the development and/or maintenance of neuronal functions. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409041  Cd Length: 107  Bit Score: 121.76  E-value: 6.61e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  126 MTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 205
Cdd:cd21192     2 GSAEKALLKWVQAEIGKYYGIRVTDFDKSWRDGVAFLALIHAIRPDLVDMKTVKNRSPRDNLELAFRIAEQHLNIPRLLE 81
                          90
                  ....*....|....*....
gi 254675251  206 PEDVDVPQPDEKSIITYVS 224
Cdd:cd21192    82 VEDVLVDKPDERSIMTYVS 100
CH_SpAIN1-like_rpt2 cd21291
second calponin homology (CH) domain found in Schizosaccharomyces pombe alpha-actinin-like ...
114-229 8.87e-32

second calponin homology (CH) domain found in Schizosaccharomyces pombe alpha-actinin-like protein 1 and similar proteins; Schizosaccharomyces pombe alpha-actinin-like protein 1 (SpAIN1) binds to actin and is involved in actin-ring formation and organization. It plays a role in cytokinesis and is involved in septation. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409140  Cd Length: 115  Bit Score: 121.87  E-value: 8.87e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  114 ISDIQvsgqSEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSV 193
Cdd:cd21291     1 IADIN----EEGLTAKEGLLLWCQRKTAGYDEVDVQDFTTSWTDGLAFCALIHRHRPDLIDYDKLDKKDHRGNMQLAFDI 76
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 254675251  194 AERDLGVTRLLDPEDV-DVPQPDEKSIITYVSSLYDA 229
Cdd:cd21291    77 ASKEIGIPQLLDVEDVcDVAKPDERSIMTYVAYYFHA 113
CH_UTRN_rpt2 cd21234
second calponin homology (CH) domain found in utrophin and similar proteins; Utrophin, also ...
130-231 9.30e-32

second calponin homology (CH) domain found in utrophin and similar proteins; Utrophin, also called dystrophin-related protein 1 (DRP-1), is an autosomal dystrophin homolog that increases dystrophic muscle function and reduces pathology. It is broadly expressed in both the mRNA and protein levels, and occurs in the cerebrovascular endothelium. Utrophin forms the utrophin-glycoprotein complex (UGC) by interacting with dystroglycans (DGs) and sarcoglycan-dystroglycans, as well as sarcoglycan and sarcospan (SG-SSPN) subcomplexes. It may act as a scaffolding protein that stabilizes lipid microdomains and clusters mechanosensitive channel subunits, and link the F-actin cytoskeleton to the cell membrane via the associated glycoprotein complex. Like dystrophin, utrophin has a compact cluster of domains comprising four EF-hand-like motifs and a ZZ-domain, followed by a looser region with two coiled-coils. These domains are believed to be involved in protein-protein interactions. In addition, it contains two syntrophin binding sites (SBSs) and a long N-terminal extension that comprises two actin-binding calponin homology (CH) domains, up to 24 spectrin repeats (SRs), and a WW domain. However, utrophin lacks the intrinsic microtubule binding activity of dystrophin SRs. This model corresponds to the second CH domain.


Pssm-ID: 409083 [Multi-domain]  Cd Length: 104  Bit Score: 121.22  E-value: 9.30e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  130 EKLLL-WSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED 208
Cdd:cd21234     2 EKILLsWVRQSTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKMSPVERLEHAFSKAKNHLGIEKLLDPED 81
                          90       100
                  ....*....|....*....|...
gi 254675251  209 VDVPQPDEKSIITYVSSLYDAMP 231
Cdd:cd21234    82 VAVQLPDKKSIIMYLTSLFEVLP 104
CH_MICALL2 cd21253
calponin homology (CH) domain found in MICAL-like protein 2 and similar proteins; MICAL-like ...
132-227 1.21e-30

calponin homology (CH) domain found in MICAL-like protein 2 and similar proteins; MICAL-like protein 2 (MICAL-L2), also called junctional Rab13-binding protein (JRAB), or molecule interacting with CasL-like 2, acts as an effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecule transport to the plasma membrane, and actin cytoskeleton reorganization. It regulates the endocytic recycling of occludins, claudins, and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. Members of this subfamily contain a single copy of CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409102  Cd Length: 106  Bit Score: 118.22  E-value: 1.21e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  132 LLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED-VD 210
Cdd:cd21253     6 LQQWCRQQTEGYRDVKVTNMTTSWRDGLAFCAIIHRFRPDLIDFDSLSKENVYENNKLAFTVAEKELGIPALLDAEDmVA 85
                          90
                  ....*....|....*..
gi 254675251  211 VPQPDEKSIITYVSSLY 227
Cdd:cd21253    86 LKVPDKLSILTYVSQYY 102
CH_DMD_rpt2 cd21233
second calponin homology (CH) domain found in dystrophin and similar proteins; Dystrophin, ...
130-232 2.01e-30

second calponin homology (CH) domain found in dystrophin and similar proteins; Dystrophin, encoded by the DMD gene, is a large, submembrane cytoskeletal protein that is the main component of the dystrophin-glycoprotein complex (DGC) in skeletal muscles. It links the transmembrane DGC to the actin cytoskeleton through binding strongly to the cytoplasmic tail of beta-dystroglycan, the transmembrane subunit of a highly O-glycosylated cell-surface protein. It is involved in maintaining the structural integrity of cells, as well as in the formation of the blood-brain barrier (BBB). Mutations in dystrophin lead to Duchenne muscular dystrophy (DMD). Moreover, dystrophin deficiency is associated with abnormal cerebral diffusion and perfusion, as well as in acute Trypanosoma cruzi infection. The dystrophin subfamily has been characterized by a compact cluster of domains comprising four EF-hand-like motifs and a ZZ-domain, followed by a looser region with two coiled-coils. These domains are believed to be involved in protein-protein interactions. In addition, dystrophin contains two syntrophin binding sites (SBSs) and a long N-terminal extension that comprises two actin-binding calponin homology (CH) domains, approximately 24 spectrin repeats (SRs) and a WW domain. The model corresponds to the second CH domain.


Pssm-ID: 409082  Cd Length: 111  Bit Score: 117.72  E-value: 2.01e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  130 EKLLL-WSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTN-LENLDQAFSVAERDLGVTRLLDPE 207
Cdd:cd21233     2 EKILLsWVRQSTRNYPQVNVINFTSSWSDGLAFNALIHSHRPDLFDWNSVVSQQSaTERLDHAFNIARQHLGIEKLLDPE 81
                          90       100
                  ....*....|....*....|....*
gi 254675251  208 DVDVPQPDEKSIITYVSSLYDAMPR 232
Cdd:cd21233    82 DVATAHPDKKSILMYVTSLFQVLPQ 106
CH_SYNE2_rpt2 cd21244
second calponin homology (CH) domain found in synaptic nuclear envelope protein 2 (SYNE-2) and ...
126-224 2.92e-30

second calponin homology (CH) domain found in synaptic nuclear envelope protein 2 (SYNE-2) and similar proteins; SYNE-2, also called nesprin-2, KASH domain-containing protein 2 (KASH2), nuclear envelope spectrin repeat protein 2, nucleus and actin connecting element protein, or protein NUANCE, is a multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain subcellular spatial organization. SYNE-2 also acts as a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, which is involved in the connection between the nuclear lamina and the cytoskeleton. SYNE-2 contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409093  Cd Length: 109  Bit Score: 117.24  E-value: 2.92e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  126 MTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 205
Cdd:cd21244     4 MSARKALLLWAQEQCAKVGSISVTDFKSSWRNGLAFLAIIHALRPGLVDMEKLKGRSNRENLEEAFRIAEQELKIPRLLE 83
                          90
                  ....*....|....*....
gi 254675251  206 PEDVDVPQPDEKSIITYVS 224
Cdd:cd21244    84 PEDVDVVNPDEKSIMTYVA 102
CH_ACTN4_rpt2 cd21290
second calponin homology (CH) domain found in alpha-actinin-4; Alpha-actinin-4 (ACTN4), also ...
112-239 3.62e-30

second calponin homology (CH) domain found in alpha-actinin-4; Alpha-actinin-4 (ACTN4), also called non-muscle alpha-actinin 4, is an F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. It is associated with cell motility and cancer invasion. ACTN4 is probably involved in vesicular trafficking via its association with the CART complex, which is necessary for efficient transferrin receptor recycling but not for epidermal growth factor receptor (EGFR) degradation. It contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409139  Cd Length: 125  Bit Score: 117.49  E-value: 3.62e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  112 FQISDIQVsgqsEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAF 191
Cdd:cd21290     2 FAIQDISV----EETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAF 77
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 254675251  192 SVAERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMprvPGAQDG 239
Cdd:cd21290    78 EVAEKYLDIPKMLDAEDiVNTARPDEKAIMTYVSSFYHAF---SGAQKA 123
CH_CLMN_rpt1 cd21191
first calponin homology (CH) domain found in calmin and similar proteins; Calmin, also called ...
7-116 3.95e-30

first calponin homology (CH) domain found in calmin and similar proteins; Calmin, also called calponin-like transmembrane domain protein, is a protein with calponin homology (CH) and transmembrane domains expressed in maturing spermatogenic cells. It may be involved in the development and/or maintenance of neuronal functions. Calmin contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409040  Cd Length: 114  Bit Score: 117.30  E-value: 3.95e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    7 ERDRVQKKTFTKWVNKHLIKAQR--HISDLYEDLRDGHNLISLLEVLSGDSLPRE--KGRMRFHKLQNVQIALDYLRHRQ 82
Cdd:cd21191     1 ERENVQKRTFTRWINLHLEKCNPplEVKDLFVDIQDGKILMALLEVLSGQNLLQEykPSSHRIFRLNNIAKALKFLEDSN 80
                          90       100       110
                  ....*....|....*....|....*....|....
gi 254675251   83 VKLVNIRNDDIADGNPKLTLGLIWTIILHFQISD 116
Cdd:cd21191    81 VKLVSIDAAEIADGNPSLVLGLIWNIILFFQIKE 114
CH_FLN-like_rpt1 cd21183
first calponin homology (CH) domain found in the filamin family; The filamin family includes ...
10-112 8.49e-30

first calponin homology (CH) domain found in the filamin family; The filamin family includes filamin-A (FLN-A), filamin-B (FLN-B) and filamin-C (FLN-C). Filamins function to anchor various transmembrane proteins to the actin cytoskeleton. FLN-A is also called actin-binding protein 280 (ABP-280), alpha-filamin, endothelial actin-binding protein, filamin-1, or non-muscle filamin. It promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. It also serves as a scaffold for a wide range of cytoplasmic signaling proteins. FLN-B is also called ABP-278, ABP-280 homolog, actin-binding-like protein, beta-filamin, filamin homolog 1 (Fh1), filamin-3, thyroid autoantigen, truncated actin-binding protein, or truncated ABP. It connects cell membrane constituents to the actin cytoskeleton and may also promote orthogonal branching of actin filaments as well as link actin filaments to membrane glycoproteins. FLN-C, also called FLNc, ABP-280-like protein, ABP-L, actin-binding-like protein, filamin-2, or gamma-filamin, is a muscle-specific filamin that plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. It may be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. FLN-C is critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. This family also includes Drosophila melanogaster protein jitterbug (Jbug), which is an actin-meshwork organizing protein containing three copies of the CH domain. Other members of this family contain two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409032  Cd Length: 108  Bit Score: 116.04  E-value: 8.49e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   10 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---EKGRMRFHKLQNVQIALDYLRHRQVKLV 86
Cdd:cd21183     3 RIQANTFTRWCNEHLKERGMQIHDLATDFSDGLCLIALLENLSTRPLKRsynRRPAFQQHYLENVSTALKFIEADHIKLV 82
                          90       100
                  ....*....|....*....|....*.
gi 254675251   87 NIRNDDIADGNPKLTLGLIWTIILHF 112
Cdd:cd21183    83 NIGSGDIVNGNIKLILGLIWTLILHY 108
PTZ00121 PTZ00121
MAEBL; Provisional
1687-2534 3.20e-29

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 129.88  E-value: 3.20e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1687 TEQGEQQRQLLEEELARLQHEATAATqkRQELEAELAKVR------AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1760
Cdd:PTZ00121 1033 TEYGNNDDVLKEKDIIDEDIDGNHEG--KAEAKAHVGQDEglkpsyKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGK 1110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1761 FRElAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEdeaf 1840
Cdd:PTZ00121 1111 AEE-ARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAE---- 1185
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1841 QRRRLEEqaaLHKADIEERLAQLRKASEselerqkglvEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNA 1920
Cdd:PTZ00121 1186 EVRKAEE---LRKAEDARKAEAARKAEE----------ERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNE 1252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1921 EdtMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKValEEVERLKAKVEEARRLRERAEQesarq 2000
Cdd:PTZ00121 1253 E--IRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEK--KKADEAKKKAEEAKKADEAKKK----- 1323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2001 lqlAQEAAQKRLQAEEKAhafvvqqreeelqqtlqqeqnmldrlrseaeaarraaeeaeeareqaereaaQSRKQVEEAE 2080
Cdd:PTZ00121 1324 ---AEEAKKKADAAKKKA----------------------------------------------------EEAKKAAEAA 1348
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2081 RLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQtLRQKAQVEQELTTLRLQL 2160
Cdd:PTZ00121 1349 KAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKADE-LKKAAAAKKKADEAKKKA 1427
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2161 EETDHQksildEELQRLKAEVTEAARQRSQVEEelfsvRVQMEELGKlkaRIEAENRALILRDKDNTQRFLEE---EAEK 2237
Cdd:PTZ00121 1428 EEKKKA-----DEAKKKAEEAKKADEAKKKAEE-----AKKAEEAKK---KAEEAKKADEAKKKAEEAKKADEakkKAEE 1494
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2238 MKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK----EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQE 2313
Cdd:PTZ00121 1495 AKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKadeaKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEE 1574
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2314 DKeQMAQQLVEETQgfqrtlEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKqAEEIGEKLHRTELATQEKV 2393
Cdd:PTZ00121 1575 DK-NMALRKAEEAK------KAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKK-AEEEKKKVEQLKKKEAEEK 1646
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2394 TLVQTL-------EIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQ-----EQILQETQALQKSFL 2461
Cdd:PTZ00121 1647 KKAEELkkaeeenKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEElkkkeAEEKKKAEELKKAEE 1726
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251 2462 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRK 2534
Cdd:PTZ00121 1727 ENKIKAEEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKK 1799
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1134-2018 5.22e-29

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 128.68  E-value: 5.22e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1134 ERDVEVERWRERVTQLLERwqavlaqtdvRQRELEQLGRQLRYYRESADplsawlqDAKRRQEQIQAVPIANCQAAREQL 1213
Cdd:COG1196   172 ERKEEAERKLERTEENLER----------LEDLLEELEKQLEKLERQAE-------KAERYQELKAELRELELALLLAKL 234
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1214 RQEKALLEEIErhgEKVEECQKFAKQYINAIKDYELQLITYKAQLEpvaspakkpkvqsgsesviqeyvDLRTRYSELTT 1293
Cdd:COG1196   235 KELRKELEELE---EELSRLEEELEELQEELEEAEKEIEELKSELE-----------------------ELREELEELQE 288
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1294 LTSQyikfISETLRRMEEEERLAEQQRAEERERLAEVEAALEKqrqlAEAHAQAKAQAELEAQELQRRMQEEVARREEAA 1373
Cdd:COG1196   289 ELLE----LKEEIEELEGEISLLRERLEELENELEELEERLEE----LKEKIEALKEELEERETLLEELEQLLAELEEAK 360
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1374 VDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQ 1453
Cdd:COG1196   361 EELEEKLSALLEELEELFEALREELAELEAELAEIRNELEELKREIESLEERLERLSERLEDLKEELKELEAELEELQTE 440
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1454 KRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERA-------- 1525
Cdd:COG1196   441 LEELNEELEELEEQLEELRDRLKELERELAELQEELQRLEKELSSLEARLDRLEAEQRASQGVRAVLEALESglpgvygp 520
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1526 --------RQVQVALETA--QRSAEVELQSKRAsfAEKTAQLERTLQEEHVTVAQLrEEAERRAQQQAEAERAREEAERE 1595
Cdd:COG1196   521 vaelikvkEKYETALEAAlgNRLQAVVVENEEV--AKKAIEFLKENKAGRATFLPL-DRIKPLRSLKSDAAPGFLGLASD 597
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1596 LERWQLKANEALRLRLQAEEVAqqKSLAQADAEKQKEEAEREARRRGKAE----------EQAVRQRELAEQELEKQRQL 1665
Cdd:COG1196   598 LIDFDPKYEPAVRFVLGDTLVV--DDLEQARRLARKLRIKYRIVTLDGDLvepsgsitggSRNKRSSLAQKRELKELEEE 675
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1666 AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEEsrs 1745
Cdd:COG1196   676 LAELEAQLEKLEEELKSLKNELRSLEDLLEELRRQLEELERQLEELKRELAALEEELEQLQSRLEELEEELEELEEE--- 752
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1746 tSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKE 1825
Cdd:COG1196   753 -LEELQERLEELEEELESLEEALAKLKEEIEELEEKRQALQEELEELEEELEEAERRLDALERELESLEQRRERLEQEIE 831
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1826 AENERLRRLAEDEAFQRRRLEE---QAALHKADIEERLAQLRKAsESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKA 1902
Cdd:COG1196   832 ELEEEIEELEEKLDELEEELEElekELEELKEELEELEAEKEEL-EDELKELEEEKEELEEELRELESELAELKEEIEKL 910
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1903 AAGKAELELELGR---IRSNAEDTMRSKEQAELEAARQRQLAAeeeqrrreaeervqrslaAEEEAARQRKV---ALEEV 1976
Cdd:COG1196   911 RERLEELEAKLERlevELPELEEELEEEYEDTLETELEREIER------------------LEEEIEALGPVnlrAIEEY 972
                         890       900       910       920
                  ....*....|....*....|....*....|....*....|..
gi 254675251 1977 ERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKA 2018
Cdd:COG1196   973 EEVEERYEELKSQREDLEEAKEKLLEVIEELDKEKRERFKET 1014
Spectrin_like pfam18373
Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links ...
859-936 5.92e-29

Spectrin like domain; Desmoplakin (DP) is an integral part of desmosomes, where it links desmosomal cadherins to the intermediate filaments. The N-terminal region of DP contains a plakin domain common to members of the plakin family. Plakin domains contain multiple copies of spectrin repeats (SRs) pfam00435. Spectrin repeats (SRs) consist of three alpha-helices (A, B, and C) that form an antiparallel triple-helical bundle. This entry describes SR6 which has a divergent structure relative to the other SRs. SR6 shows significant deviations in helices A and B where they are significantly shorter than in other repeats. Structural comparison revealed that SR6 is more similar to other three-helix-bundle proteins, including target of Myb1 and the syntaxin Habc domain, than to other SR proteins. Due to these differences with other spectrin repeats, this region is termed spectrin-like repeat.


Pssm-ID: 436447  Cd Length: 78  Bit Score: 112.30  E-value: 5.92e-29
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251   859 LAWQSLSRDIQLIRSWSLVTFRTLKPEEQRQALRNLELHYQAFLRDSQDAGGFGPEDRLVAEREYGSCSRHYQQLLQS 936
Cdd:pfam18373    1 VSWQYLLKDIERIRSWTISMLKTMRPEEYRQVLKNLETHYQDFLRDSQESEMFGAEDRRQLEREVNACQQHYQTLLVS 78
CH_MICAL_EHBP-like cd22198
calponin homology (CH) domain found in the MICAL and EHBP families; This group is composed of ...
130-229 2.63e-28

calponin homology (CH) domain found in the MICAL and EHBP families; This group is composed of the molecule interacting with CasL protein (MICAL) and EH domain-binding protein (EHBP) families. MICAL is a large, multidomain, cytosolic protein with a single LIM domain, a calponin homology (CH) domain and a flavoprotein monooxygenase (MO) domain. In Drosophila, MICAL is expressed in axons, interacts with the neuronal A (PlexA) receptor and is required for Semaphorin 1a (Sema-1a)-PlexA-mediated repulsive axon guidance. The LIM and CH domains mediate interactions with the cytoskeleton, cytoskeletal adaptor proteins, and other signaling proteins. The flavoprotein MO is required for semaphorin-plexin repulsive axon guidance during axonal pathfinding in the Drosophila neuromuscular system. The EHBP family includes EHBP1 and EHBP1-like protein (EHBP1L1). EHBP1 is a regulator of endocytic recycling and may play a role in actin reorganization by linking clathrin-mediated endocytosis to the actin cytoskeleton. It may act as an effector of small GTPases, including RAB-10 (Rab10), and play a role in vesicle trafficking. EHBP proteins contain a single CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409188  Cd Length: 105  Bit Score: 111.61  E-value: 2.63e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  130 EKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED- 208
Cdd:cd22198     3 EELLSWCQEQTEGYRGVKVTDLTSSWRSGLALCAIIHRFRPDLIDFSSLDPENIAENNQLAFDVAEQELGIPPVMTGQEm 82
                          90       100
                  ....*....|....*....|.
gi 254675251  209 VDVPQPDEKSIITYVSSLYDA 229
Cdd:cd22198    83 ASLAVPDKLSMVSYLSQFYEA 103
CH_ACTN1_rpt2 cd21287
second calponin homology (CH) domain found in alpha-actinin-1; Alpha-actinin-1 (ACTN1), also ...
114-238 5.29e-28

second calponin homology (CH) domain found in alpha-actinin-1; Alpha-actinin-1 (ACTN1), also called alpha-actinin cytoskeletal isoform, or non-muscle alpha-actinin-1, is an F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. ACTN1 is a bundling protein. Its mutations cause congenital macrothrombocytopenia. It contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409136  Cd Length: 124  Bit Score: 111.33  E-value: 5.29e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  114 ISDIQVsgqsEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSV 193
Cdd:cd21287     1 IQDISV----EETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPELIDYGKLRKDDPLTNLNTAFDV 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 254675251  194 AERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDAMprvPGAQD 238
Cdd:cd21287    77 AEKYLDIPKMLDAEDiVGTARPDEKAIMTYVSSFYHAF---SGAQK 119
CH_FLN_rpt1 cd21228
first calponin homology (CH) domain found in filamins; The filamin family includes filamin-A ...
10-112 3.95e-27

first calponin homology (CH) domain found in filamins; The filamin family includes filamin-A (FLN-A), filamin-B (FLN-B) and filamin-C (FLN-C). Filamins function to anchor various transmembrane proteins to the actin cytoskeleton. FLN-A is also called actin-binding protein 280 (ABP-280), alpha-filamin, endothelial actin-binding protein, filamin-1, or non-muscle filamin. It promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. It also serves as a scaffold for a wide range of cytoplasmic signaling proteins. FLN-B is also called ABP-278, ABP-280 homolog, actin-binding-like protein, beta-filamin, filamin homolog 1 (Fh1), filamin-3, thyroid autoantigen, truncated actin-binding protein, or truncated ABP. It connects cell membrane constituents to the actin cytoskeleton and may also promote orthogonal branching of actin filaments as well as link actin filaments to membrane glycoproteins. FLN-C, also called FLNc, ABP-280-like protein, ABP-L, actin-binding-like protein, filamin-2, or gamma-filamin, is a muscle-specific filamin that plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. It may be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. FLN-C is critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. Members of this family contain two copies of the CH domain. The model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409077  Cd Length: 108  Bit Score: 108.34  E-value: 3.95e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   10 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---EKGRMRFHKLQNVQIALDYLRHRQVKLV 86
Cdd:cd21228     3 KIQQNTFTRWCNEHLKCVNKRIYNLETDLSDGLRLIALLEVLSQKRMYKkynKRPTFRQMKLENVSVALEFLERESIKLV 82
                          90       100
                  ....*....|....*....|....*.
gi 254675251   87 NIRNDDIADGNPKLTLGLIWTIILHF 112
Cdd:cd21228    83 SIDSSAIVDGNLKLILGLIWTLILHY 108
CH_ACTN3_rpt2 cd21289
second calponin homology (CH) domain found in alpha-actinin-3; Alpha-actinin-3 (ACTN3), also ...
114-229 8.93e-27

second calponin homology (CH) domain found in alpha-actinin-3; Alpha-actinin-3 (ACTN3), also called alpha-actinin skeletal muscle isoform 3, is an F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. ACTN3 is a bundling protein. It is critical in anchoring the myofibrillar actin filaments and plays a key role in muscle contraction. It contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409138  Cd Length: 124  Bit Score: 107.89  E-value: 8.93e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  114 ISDIQVsgqsEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSV 193
Cdd:cd21289     1 IQDISV----EETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPDLIDYAKLRKDDPIGNLNTAFEV 76
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 254675251  194 AERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDA 229
Cdd:cd21289    77 AEKYLDIPKMLDAEDiVNTPKPDEKAIMTYVSCFYHA 113
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1208-1996 1.05e-26

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 120.93  E-value: 1.05e-26
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1208 AAREQLRQEKALLEEIERHGEKVEECQKFAKQYI---NAIKDYELQLITYkaqlepvaspakkpkvqsgsesviqEYVDL 1284
Cdd:TIGR02168  183 RTRENLDRLEDILNELERQLKSLERQAEKAERYKelkAELRELELALLVL-------------------------RLEEL 237
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1285 RTRYSELTTLTSQYikfiSETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQE 1364
Cdd:TIGR02168  238 REELEELQEELKEA----EEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLAN 313
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1365 EVARREEAAVDAQQQKRSIQE------ELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEG 1438
Cdd:TIGR02168  314 LERQLEELEAQLEELESKLDElaeelaELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLEL 393
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1439 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRAlqALDELRLQAEEAERRLR 1518
Cdd:TIGR02168  394 QIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQE--ELERLEEALEELREELE 471
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1519 QAEAERarqvqvaletaqRSAEVELQSKRASFAEKTAQLERtLQEEHVTVAQLREEAERRAQQQAEAERAREEAerelER 1598
Cdd:TIGR02168  472 EAEQAL------------DAAERELAQLQARLDSLERLQEN-LEGFSEGVKALLKNQSGLSGILGVLSELISVD----EG 534
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1599 WQLKANEALRLRLQA---EEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQE----------------- 1658
Cdd:TIGR02168  535 YEAAIEAALGGRLQAvvvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIegflgvakdlvkfdpkl 614
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1659 --------------------LEKQRQL-----------------------AEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1695
Cdd:TIGR02168  615 rkalsyllggvlvvddldnaLELAKKLrpgyrivtldgdlvrpggvitggSAKTNSSILERRREIEELEEKIEELEEKIA 694
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1696 LLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK----SKQRLEAEAGRfRELAEEAARL 1771
Cdd:TIGR02168  695 ELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERiaqlSKELTELEAEI-EELEERLEEA 773
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1772 RALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAeialKEKEAENERLRRLAEDEAFQRRRLEEQAAL 1851
Cdd:TIGR02168  774 EEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEA----ANLRERLESLERRIAATERRLEDLEEQIEE 849
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1852 HKADIEERLAQLRKASESELERQKGLvEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQ-- 1929
Cdd:TIGR02168  850 LSEDIESLAAEIEELEELIEELESEL-EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQle 928
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1930 ---AELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRkvalEEVERLKAKVEEARRLRERAEQE 1996
Cdd:TIGR02168  929 lrlEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEAR----RRLKRLENKIKELGPVNLAAIEE 994
CH_FLNC_rpt1 cd21310
first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins; Filamin-C ...
10-115 1.92e-26

first calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins; Filamin-C (FLN-C), also called FLNc, ABP-280-like protein, ABP-L, actin-binding-like protein, filamin-2, or gamma-filamin, is a muscle-specific filamin that plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. It may be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. FLN-C is critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. FLN-C contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409159  Cd Length: 125  Bit Score: 107.04  E-value: 1.92e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   10 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE---KGRMRFHKLQNVQIALDYLRHRQVKLV 86
Cdd:cd21310    15 KIQQNTFTRWCNEHLKCVQKRLNDLQKDLSDGLRLIALLEVLSQKKMYRKyhpRPNFRQMKLENVSVALEFLDREHIKLV 94
                          90       100
                  ....*....|....*....|....*....
gi 254675251   87 NIRNDDIADGNPKLTLGLIWTIILHFQIS 115
Cdd:cd21310    95 SIDSKAIVDGNLKLILGLIWTLILHYSIS 123
PTZ00121 PTZ00121
MAEBL; Provisional
1370-2016 4.10e-26

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 119.48  E-value: 4.10e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1370 EEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEE 1449
Cdd:PTZ00121 1034 EYGNNDDVLKEKDIIDEDIDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKEDNRADEATEEAFGKAEEAKKTETGKAEE 1113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1450 aEAQKRQAQEEAERLRRqvqdeSQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQ-AEEAERRLRQAEAERARQV 1528
Cdd:PTZ00121 1114 -ARKAEEAKKKAEDARK-----AEEARKAEDARKAEEARKAEDAKRVEIARKAEDARKAEeARKAEDAKKAEAARKAEEV 1187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1529 QVALETaqRSAEvelQSKRASFAEKtAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALR 1608
Cdd:PTZ00121 1188 RKAEEL--RKAE---DARKAEAARK-AEEERKAEEARKAEDAKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEAR 1261
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1609 L--------------RLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEE-----QAVRQRELAEQELEKQRQLAEGT 1669
Cdd:PTZ00121 1262 MahfarrqaaikaeeARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEakkadEAKKKAEEAKKKADAAKKKAEEA 1341
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1670 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQEL-EAELAKVRAEMEVLLASKARAEEESRSTSE 1748
Cdd:PTZ00121 1342 KKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKkKADEAKKKAEEDKKKADELKKAAAAKKKAD 1421
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1749 KSKQRLEA-----EAGRFRELAEEAARLRALAEEAKRQRQL---AEE----DAARQRAEAERVLTEKLAAISEATRLKTE 1816
Cdd:PTZ00121 1422 EAKKKAEEkkkadEAKKKAEEAKKADEAKKKAEEAKKAEEAkkkAEEakkaDEAKKKAEEAKKADEAKKKAEEAKKKADE 1501
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1817 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA---LHKADIEERLAQLRKASESELERQKGLVEDtlrQRRQVEEEIM 1893
Cdd:PTZ00121 1502 AKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKadeAKKAEEKKKADELKKAEELKKAEEKKKAEE---AKKAEEDKNM 1578
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1894 ALKVSFEKAAAGKAELELELGRIRSnaEDTMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVAL 1973
Cdd:PTZ00121 1579 ALRKAEEAKKAEEARIEEVMKLYEE--EKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAE 1656
                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|.
gi 254675251 1974 EEV----ERLKAKVEEARR----LRERAEQESARQLQLAQEAAQKRlQAEE 2016
Cdd:PTZ00121 1657 EENkikaAEEAKKAEEDKKkaeeAKKAEEDEKKAAEALKKEAEEAK-KAEE 1706
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
14-111 2.08e-25

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 103.16  E-value: 2.08e-25
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251     14 KTFTKWVNKHLIKA-QRHISDLYEDLRDGHNLISLLEVLSGDSLPREK---GRMRFHKLQNVQIALDYLRHRQVKLVNIR 89
Cdd:smart00033    1 KTLLRWVNSLLAEYdKPPVTNFSSDLKDGVALCALLNSLSPGLVDKKKvaaSLSRFKKIENINLALSFAEKLGGKVVLFE 80
                            90       100
                    ....*....|....*....|..
gi 254675251     90 NDDIADGnPKLTLGLIWTIILH 111
Cdd:smart00033   81 PEDLVEG-PKLILGVIWTLISL 101
CH_SPTBN5_rpt1 cd21247
first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 5 (SPTBN5) ...
6-114 2.45e-25

first calponin homology (CH) domain found in spectrin beta chain, non-erythrocytic 5 (SPTBN5) and similar proteins; Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is composed of two antiparallel dimers of alpha- and beta- subunits. SPTBN5, also called beta-V spectrin, is a mammalian ortholog of Drosophila beta H spectrin that may play a crucial role as a longer actin-membrane cross-linker or to fulfill the need for greater extensible flexibility than can be provided by the other smaller conventional spectrins. SPTBN5 contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409096  Cd Length: 125  Bit Score: 103.68  E-value: 2.45e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    6 DERDRVQKKTFTKWVNKHLIKAQR--HISDLYEDLRDGHNLISLLEVLSGDSLPR-EKGRMRFHKLQNVQIALDYLRHR- 81
Cdd:cd21247    15 EQRMTMQKKTFTKWMNNVFSKNGAkiEITDIYTELKDGIHLLRLLELISGEQLPRpSRGKMRVHFLENNSKAITFLKTKv 94
                          90       100       110
                  ....*....|....*....|....*....|...
gi 254675251   82 QVKLVNIRNddIADGNPKLTLGLIWTIILHFQI 114
Cdd:cd21247    95 PVKLIGPEN--IVDGDRTLILGLIWIIILRFQI 125
CH_ACTN2_rpt2 cd21288
second calponin homology (CH) domain found in alpha-actinin-2; Alpha-actinin-2 (ACTN2), also ...
114-229 2.46e-25

second calponin homology (CH) domain found in alpha-actinin-2; Alpha-actinin-2 (ACTN2), also called alpha-actinin skeletal muscle isoform 2, is an F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. ACTN2 is a bundling protein. Its mutations are associated with cardiomyopathies, as well as skeletal muscle disorder. It contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409137  Cd Length: 124  Bit Score: 104.00  E-value: 2.46e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  114 ISDIQVsgqsEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSV 193
Cdd:cd21288     1 IQDISV----EETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPDLIDYSKLNKDDPIGNINLAMEI 76
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 254675251  194 AERDLGVTRLLDPED-VDVPQPDEKSIITYVSSLYDA 229
Cdd:cd21288    77 AEKHLDIPKMLDAEDiVNTPKPDERAIMTYVSCFYHA 113
CH_MICALL cd21197
calponin homology (CH) domain found in the MICAL-like protein family; The MICAL-L family ...
132-227 2.55e-25

calponin homology (CH) domain found in the MICAL-like protein family; The MICAL-L family includes MICAL-L1 and MICAL-L2. MICAL-L1, also called molecule interacting with Rab13 (MIRab13), is a probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. It is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a. It may be involved in a late step of receptor-mediated endocytosis regulating endocytosed-EGF receptor trafficking. Alternatively, it may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. MICAL-L1 may indirectly play a role in neurite outgrowth. MICAL-L2, also called junctional Rab13-binding protein (JRAB), or molecule interacting with CasL-like 2, acts as an effector of small Rab GTPases which is involved in junctional complexes assembly through the regulation of cell adhesion molecule transport to the plasma membrane, and actin cytoskeleton reorganization. It regulates the endocytic recycling of occludins, claudins, and E-cadherin to the plasma membrane and may thereby regulate the establishment of tight junctions and adherens junctions. Members of this family contain a single copy of CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409046  Cd Length: 105  Bit Score: 103.00  E-value: 2.55e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  132 LLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED-VD 210
Cdd:cd21197     5 LLRWCRRQCEGYPGVNITNLTSSFRDGLAFCAILHRHRPELIDFHSLKKDNWLENNRLAFRVAETSLGIPALLDAEDmVT 84
                          90
                  ....*....|....*..
gi 254675251  211 VPQPDEKSIITYVSSLY 227
Cdd:cd21197    85 MHVPDRLSIITYVSQYY 101
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
126-232 8.21e-25

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596  Cd Length: 109  Bit Score: 101.59  E-value: 8.21e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   126 MTAKEKLLLWSQRMVEGY-QGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVY--RQTNLENLDQAFSVAERDLGVTR 202
Cdd:pfam00307    1 LELEKELLRWINSHLAEYgPGVRVTNFTTDLRDGLALCALLNKLAPGLVDKKKLNksEFDKLENINLALDVAEKKLGVPK 80
                           90       100       110
                   ....*....|....*....|....*....|.
gi 254675251   203 -LLDPEDVDvpQPDEKSIITYVSSLYDAMPR 232
Cdd:pfam00307   81 vLIEPEDLV--EGDNKSVLTYLASLFRRFQA 109
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1028-1877 2.97e-24

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 112.89  E-value: 2.97e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1028 LRSELELTLGKLEQVRslsaiylEKLKTISLVIRSTQGAEEVLKTHEEQLKEAQAVPATLQELEATKASLKKLRAQAEaq 1107
Cdd:COG1196   170 YKERKEEAERKLERTE-------ENLERLEDLLEELEKQLEKLERQAEKAERYQELKAELRELELALLLAKLKELRKE-- 240
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1108 qpvFNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRyyresadplsaw 1187
Cdd:COG1196   241 ---LEELEEELSRLEEELEELQEELEEAEKEIEELKSELEELREELEELQEELLELKEEIEELEGEIS------------ 305
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1188 lqDAKRRQEQIqavpianCQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQlityKAQLEpvaspAKK 1267
Cdd:COG1196   306 --LLRERLEEL-------ENELEELEERLEELKEKIEALKEELEERETLLEELEQLLAELEEA----KEELE-----EKL 367
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1268 PKVQSGSESVIQEyvdLRTRYSELTTLTSQyikfISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQA 1347
Cdd:COG1196   368 SALLEELEELFEA---LREELAELEAELAE----IRNELEELKREIESLEERLERLSERLEDLKEELKELEAELEELQTE 440
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1348 KAQAELEAQELQRRMQEEVARREEaavdAQQQKRSIQEELQHLRQsseaEIQAKAQQVEAAERSRmrieEEIRVVRLQLE 1427
Cdd:COG1196   441 LEELNEELEELEEQLEELRDRLKE----LERELAELQEELQRLEK----ELSSLEARLDRLEAEQ----RASQGVRAVLE 508
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1428 TTERQRGGAEGELQ---------------ALRARAE----EAEAQKRQAQEEAER----------LRRQVQDESQRKRQA 1478
Cdd:COG1196   509 ALESGLPGVYGPVAelikvkekyetaleaALGNRLQavvvENEEVAKKAIEFLKEnkagratflpLDRIKPLRSLKSDAA 588
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1479 EAELALRVKAEaEAAREKQRALQAL--DELRLQAEEAERRLRQAEAERARQVQVALE-----------TAQRSAEVELQS 1545
Cdd:COG1196   589 PGFLGLASDLI-DFDPKYEPAVRFVlgDTLVVDDLEQARRLARKLRIKYRIVTLDGDlvepsgsitggSRNKRSSLAQKR 667
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1546 KRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEvaQQKSLAQA 1625
Cdd:COG1196   668 ELKELEEELAELEAQLEKLEEELKSLKNELRSLEDLLEELRRQLEELERQLEELKRELAALEEELEQLQS--RLEELEEE 745
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1626 DAEKQKEEAEREARRRGKAEEQAVRQRELA--EQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELAR 1703
Cdd:COG1196   746 LEELEEELEELQERLEELEEELESLEEALAklKEEIEELEEKRQALQEELEELEEELEEAERRLDALERELESLEQRRER 825
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1704 LQHEATAATQKRQELEAELAKVRAEMEVlLASKARAEEESRSTSEKSKQRLEAEAGRFR----ELAEEAARLRALAEEAK 1779
Cdd:COG1196   826 LEQEIEELEEEIEELEEKLDELEEELEE-LEKELEELKEELEELEAEKEELEDELKELEeekeELEEELRELESELAELK 904
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1780 RQRQLAEEDAARQRAEAERVLTEklaaISEATRLKTEAEIALKEKEAENER---LRRLAEDEAFQRRRLEEQAALHK--A 1854
Cdd:COG1196   905 EEIEKLRERLEELEAKLERLEVE----LPELEEELEEEYEDTLETELEREIerlEEEIEALGPVNLRAIEEYEEVEEryE 980
                         890       900
                  ....*....|....*....|...
gi 254675251 1855 DIEERLAQLRKASESELERQKGL 1877
Cdd:COG1196   981 ELKSQREDLEEAKEKLLEVIEEL 1003
CH pfam00307
Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal ...
11-114 3.45e-24

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.


Pssm-ID: 425596  Cd Length: 109  Bit Score: 100.05  E-value: 3.45e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    11 VQKKTFTKWVNKHLIKAQRH--ISDLYEDLRDGHNLISLLEVLSGDSLP-REKGRMRFHKLQNVQIALDYLRHRQ-VKLV 86
Cdd:pfam00307    2 ELEKELLRWINSHLAEYGPGvrVTNFTTDLRDGLALCALLNKLAPGLVDkKKLNKSEFDKLENINLALDVAEKKLgVPKV 81
                           90       100
                   ....*....|....*....|....*...
gi 254675251    87 NIRNDDIADGNPKLTLGLIWTIILHFQI 114
Cdd:pfam00307   82 LIEPEDLVEGDNKSVLTYLASLFRRFQA 109
CH_MICALL1 cd21252
calponin homology (CH) domain found in MICAL-like protein 1; MICAL-like protein 1 (MICAL-L1), ...
128-227 4.41e-24

calponin homology (CH) domain found in MICAL-like protein 1; MICAL-like protein 1 (MICAL-L1), also called molecule interacting with Rab13 (MIRab13), is a probable lipid-binding protein with higher affinity for phosphatidic acid, a lipid enriched in recycling endosome membranes. It is a tubular endosomal membrane hub that connects Rab35 and Arf6 with Rab8a. It may be involved in a late step of receptor-mediated endocytosis regulating endocytosed-EGF receptor trafficking. Alternatively, it may regulate slow endocytic recycling of endocytosed proteins back to the plasma membrane. MICAL-L1 may indirectly play a role in neurite outgrowth. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409101  Cd Length: 107  Bit Score: 99.56  E-value: 4.41e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  128 AKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPE 207
Cdd:cd21252     1 ARRALQAWCRRQCEGYPGVEIRDLSSSFRDGLAFCAILHRHRPDLIDFDSLSKDNVYENNRLAFEVAERELGIPALLDPE 80
                          90       100
                  ....*....|....*....|.
gi 254675251  208 D-VDVPQPDEKSIITYVSSLY 227
Cdd:cd21252    81 DmVSMKVPDCLSIMTYVSQYY 101
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1646-2484 5.92e-24

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 112.07  E-value: 5.92e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1646 EQAVRQRELAEQELEKQRQLAegtAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKV 1725
Cdd:TIGR02168  210 EKAERYKELKAELRELELALL---VLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEEL 286
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1726 RAEMEVLLASKARAEEESRSTSEkskqrleaeagRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEK-- 1803
Cdd:TIGR02168  287 QKELYALANEISRLEQQKQILRE-----------RLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELes 355
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1804 -LAAISEATRLKTEAEIALKEKEAENERLRRLaedeafqRRRLEEQAALHKADIEERLAQLrKASESELERQKGLVEDtl 1882
Cdd:TIGR02168  356 lEAELEELEAELEELESRLEELEEQLETLRSK-------VAQLELQIASLNNEIERLEARL-ERLEDRRERLQQEIEE-- 425
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1883 RQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEdtmrsKEQAELEAARQRQLaaeeeqrrreaeervqrSLAAE 1962
Cdd:TIGR02168  426 LLKKLEEAELKELQAELEELEEELEELQEELERLEEALE-----ELREELEEAEQALD-----------------AAERE 483
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1963 EEAARQRKVALEEV-ERLKAKVEEARRLRERAEQ------------ESARQLQLAQEAA---------QKRLQAEEKAHA 2020
Cdd:TIGR02168  484 LAQLQARLDSLERLqENLEGFSEGVKALLKNQSGlsgilgvlseliSVDEGYEAAIEAAlggrlqavvVENLNAAKKAIA 563
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2021 FVVQQREEELQQTLqqeqnmLDRLRSEAEAARRAAEEAEEAREQAEREAAqsrkqVEEAERLKQSAEEQAQAQAQAQAAA 2100
Cdd:TIGR02168  564 FLKQNELGRVTFLP------LDSIKGTEIQGNDREILKNIEGFLGVAKDL-----VKFDPKLRKALSYLLGGVLVVDDLD 632
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2101 EKLRKEAEQEAARRAQAEQAALKQKQAADAEmeKHKKFAEQTLRQKaqveQELTTLRLQLEETDHQKSILDEELQRLKAE 2180
Cdd:TIGR02168  633 NALELAKKLRPGYRIVTLDGDLVRPGGVITG--GSAKTNSSILERR----REIEELEEKIEELEEKIAELEKALAELRKE 706
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2181 VTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALiLRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQ 2260
Cdd:TIGR02168  707 LEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQL-EERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIE 785
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2261 LAEEDLAQQRALAEKmLKEKMQAVQ-EATRLKAEAellqQQKELAQEQARRLQEDKEQMAQQLVEETQgfqrtleaerqr 2339
Cdd:TIGR02168  786 ELEAQIEQLKEELKA-LREALDELRaELTLLNEEA----ANLRERLESLERRIAATERRLEDLEEQIE------------ 848
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2340 qlEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2419
Cdd:TIGR02168  849 --ELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251  2420 LEREKEKLKQE-AKLLQLKSEEMQTVQQEqilqetqALQKSFLSEKDSLLQRERfIEQEKAKLEQL 2484
Cdd:TIGR02168  927 LELRLEGLEVRiDNLQERLSEEYSLTLEE-------AEALENKIEDDEEEARRR-LKRLENKIKEL 984
CH_EHBP cd21198
calponin homology (CH) domain found in the EH domain-binding protein (EHBP) family; The EHBP ...
127-227 1.08e-23

calponin homology (CH) domain found in the EH domain-binding protein (EHBP) family; The EHBP family includes EHBP1 and EHBP1-like protein (EHBP1L1). EHBP1 is a regulator of endocytic recycling and may play a role in actin reorganization by linking clathrin-mediated endocytosis to the actin cytoskeleton. It may act as an effector of small GTPases, including RAB-10 (Rab10), and play a role in vesicle trafficking. EHBP1 is associated with aggressive prostate cancer and insulin-stimulated trafficking and cell migration. EHBP1L1 may also act as Rab effector protein and play a role in vesicle trafficking. It coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409047  Cd Length: 105  Bit Score: 98.27  E-value: 1.08e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERdLGVTRLLDP 206
Cdd:cd21198     1 SSGQDLLEWCQEVTKGYRGVKITNLTTSWRNGLAFCAILHHFRPDLIDFSSLSPHDIKENCKLAFDAAAK-LGIPRLLDP 79
                          90       100
                  ....*....|....*....|..
gi 254675251  207 EDVDVPQ-PDEKSIITYVSSLY 227
Cdd:cd21198    80 ADMVLLSvPDKLSVMTYLHQIR 101
CH_CTX_rpt2 cd21226
second calponin homology (CH) domain found in cortexillin; Cortexillins are actin-bundling ...
130-230 1.31e-23

second calponin homology (CH) domain found in cortexillin; Cortexillins are actin-bundling proteins that play a critical role in regulating cell morphology and actin cytoskeleton reorganization. They play a major role in cytokinesis and contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409075  Cd Length: 103  Bit Score: 97.92  E-value: 1.31e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  130 EKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPEDV 209
Cdd:cd21226     3 DGLLAWCRQTTEGYDGVNITSFKSSFNDGRAFLALLHAYDPELFKQAAIEQMDAEARLNLAFDFAEKKLGIPKLLEAEDV 82
                          90       100
                  ....*....|....*....|.
gi 254675251  210 DVPQPDEKSIITYVSSLYDAM 230
Cdd:cd21226    83 MTGNPDERSIVLYTSLFYHAF 103
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1650-2441 4.94e-23

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 109.03  E-value: 4.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1650 RQRELAEQELEKQRQLaegtaqQRLAAEQELIRLRAETEQgeqqRQLLEEELARLQHEATAATQKRQELEAELAKVRAEM 1729
Cdd:COG1196   207 RQAEKAERYQELKAEL------RELELALLLAKLKELRKE----LEELEEELSRLEEELEELQEELEEAEKEIEELKSEL 276
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1730 EVLLASKARAEEESRSTSEKsKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISE 1809
Cdd:COG1196   277 EELREELEELQEELLELKEE-IEELEGEISLLRERLEELENELEELEERLEELKEKIEALKEELEERETLLEELEQLLAE 355
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1810 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLrkasESELERQKGLVEDTLRQRRQVE 1889
Cdd:COG1196   356 LEEAKEELEEKLSALLEELEELFEALREELAELEAELAEIRNELEELKREIESL----EERLERLSERLEDLKEELKELE 431
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1890 EEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQRQlaaeeeqrrreaeervqrslaaEEEAARQR 1969
Cdd:COG1196   432 AELEELQTELEELNEELEELEEQLEELRDRLKELERELAELQEELQRLEK----------------------ELSSLEAR 489
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1970 KVALEEVERLKAKVEEARRLRERAEQESARQL----------QLAQEAAqkrlqAEEKAHAFVVQQREEELQQTLQQEQN 2039
Cdd:COG1196   490 LDRLEAEQRASQGVRAVLEALESGLPGVYGPVaelikvkekyETALEAA-----LGNRLQAVVVENEEVAKKAIEFLKEN 564
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2040 --------MLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQV-------------EEAERLkqsAEEQAQAQAQAQA 2098
Cdd:COG1196   565 kagratflPLDRIKPLRSLKSDAAPGFLGLASDLIDFDPKYEPAVrfvlgdtlvvddlEQARRL---ARKLRIKYRIVTL 641
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2099 AAEKLRKEAE----QEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQ----KAQVEQELTTLRLQLEETDHQKSIL 2170
Cdd:COG1196   642 DGDLVEPSGSitggSRNKRSSLAQKRELKELEEELAELEAQLEKLEEELKSlkneLRSLEDLLEELRRQLEELERQLEEL 721
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2171 DEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRfLEEEAEKMKQVAEEAARLSV 2250
Cdd:COG1196   722 KRELAALEEELEQLQSRLEELEEELEELEEELEELQERLEELEEELESLEEALAKLKEE-IEELEEKRQALQEELEELEE 800
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2251 AAQEAARLRQLAEEDLAQQRALAEKMLKEKmqavqeatrlkaeAELLQQQKELAQEQA------RRLQEDKEQMAQQLVE 2324
Cdd:COG1196   801 ELEEAERRLDALERELESLEQRRERLEQEI-------------EELEEEIEELEEKLDeleeelEELEKELEELKEELEE 867
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2325 ETQGFQRT---LEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEI 2401
Cdd:COG1196   868 LEAEKEELedeLKELEEEKEELEEELRELESELAELKEEIEKLRERLEELEAKLERLEVELPELEEELEEEYEDTLETEL 947
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 2402 QRQQSDHDA----------------ERLREAIAELEREKEKLKQEAKLLQLKSEEM 2441
Cdd:COG1196   948 EREIERLEEeiealgpvnlraieeyEEVEERYEELKSQREDLEEAKEKLLEVIEEL 1003
CH_CLMN_rpt2 cd21245
second calponin homology (CH) domain found in calmin and similar proteins; Calmin, also called ...
127-231 7.63e-23

second calponin homology (CH) domain found in calmin and similar proteins; Calmin, also called calponin-like transmembrane domain protein, is a protein with calponin homology (CH) and transmembrane domains expressed in maturing spermatogenic cells. It may be involved in the development and/or maintenance of neuronal functions. Calmin contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409094  Cd Length: 106  Bit Score: 96.01  E-value: 7.63e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYqGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDP 206
Cdd:cd21245     3 KAIKALLNWVQRRTRKY-GVAVQDFGSSWRSGLAFLALIKAIDPSLVDMRQALEKSPRENLEDAFRIAQESLGIPPLLEP 81
                          90       100
                  ....*....|....*....|....*
gi 254675251  207 EDVDVPQPDEKSIITYVSSLYDAMP 231
Cdd:cd21245    82 EDVMVDSPDEQSIMTYVAQFLEHFP 106
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1316-2020 1.62e-22

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 107.45  E-value: 1.62e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1316 AEQQRAEERERLAEVEAAL-EKQRQLAEAHAQA-KAQAELEAQELQRRMQEEV-ARREEAAVDAQQQKRSIQEELQHLRQ 1392
Cdd:TIGR02168  177 TERKLERTRENLDRLEDILnELERQLKSLERQAeKAERYKELKAELRELELALlVLRLEELREELEELQEELKEAEEELE 256
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1393 SSEAEIQAKAQQVEAAERSRMRIEEEIRVvrlqletterqrggAEGELQALRARAEEAEAQKRQAQEEAERLRR------ 1466
Cdd:TIGR02168  257 ELTAELQELEEKLEELRLEVSELEEEIEE--------------LQKELYALANEISRLEQQKQILRERLANLERqleele 322
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1467 -QVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLR--QAEAERarqvqvaletaQRSAEVEL 1543
Cdd:TIGR02168  323 aQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEelEEQLET-----------LRSKVAQL 391
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1544 QSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLA 1623
Cdd:TIGR02168  392 ELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELE 471
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1624 QADAEKQKEeaerearrrgKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQ---------ELIRLRAETEQG--- 1690
Cdd:TIGR02168  472 EAEQALDAA----------ERELAQLQARlDSLERLQENLEGFSEGVKALLKNQSGlsgilgvlsELISVDEGYEAAiea 541
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1691 --------------EQQRQ----LLEEELARL----------------QHEATAATQKRQELEAELAKVRAEMEVLLA-- 1734
Cdd:TIGR02168  542 alggrlqavvvenlNAAKKaiafLKQNELGRVtflpldsikgteiqgnDREILKNIEGFLGVAKDLVKFDPKLRKALSyl 621
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1735 --------SKARAEEESRSTSEK-----------------SKQRLEAEAGRF---RELAEEAARLRALAEEAKRQRQlAE 1786
Cdd:TIGR02168  622 lggvlvvdDLDNALELAKKLRPGyrivtldgdlvrpggviTGGSAKTNSSILerrREIEELEEKIEELEEKIAELEK-AL 700
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1787 EDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEErLAQLRKA 1866
Cdd:TIGR02168  701 AELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEE-AEEELAE 779
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1867 SESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQRQlaaeeeq 1946
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSE------- 852
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251  1947 rrreAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLqlaQEAAQKRLQAEEKAHA 2020
Cdd:TIGR02168  853 ----DIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEEL---RELESKRSELRRELEE 919
CH_FLN-like_rpt2 cd21184
second calponin homology (CH) domain found in the filamin family; The filamin family includes ...
127-225 2.32e-22

second calponin homology (CH) domain found in the filamin family; The filamin family includes filamin-A (FLN-A), filamin-B (FLN-B) and filamin-C (FLN-C). Filamins function to anchor various transmembrane proteins to the actin cytoskeleton. FLN-A is also called actin-binding protein 280 (ABP-280), alpha-filamin, endothelial actin-binding protein, filamin-1, or non-muscle filamin. It promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. It also serves as a scaffold for a wide range of cytoplasmic signaling proteins. FLN-B is also called ABP-278, ABP-280 homolog, actin-binding-like protein, beta-filamin, filamin homolog 1 (Fh1), filamin-3, thyroid autoantigen, truncated actin-binding protein, or truncated ABP. It connects cell membrane constituents to the actin cytoskeleton and may also promote orthogonal branching of actin filaments as well as link actin filaments to membrane glycoproteins. FLN-C, also called FLNc, ABP-280-like protein, ABP-L, actin-binding-like protein, filamin-2, or gamma-filamin, is a muscle-specific filamin that plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. It may be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. FLN-C is critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. This family also includes Drosophila melanogaster protein jitterbug (Jbug), which is an actin-meshwork organizing protein containing three copies of the CH domain. Other members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409033  Cd Length: 103  Bit Score: 94.61  E-value: 2.32e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYqglRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVY-RQTNLENLDQAFSVAERDLGVTRLLD 205
Cdd:cd21184     1 SGKSLLLEWVNSKIPEY---KVKNFTTDWNDGKALAALVDALKPGLIPDNESLdKENPLENATKAMDIAEEELGIPKIIT 77
                          90       100
                  ....*....|....*....|
gi 254675251  206 PEDVDVPQPDEKSIITYVSS 225
Cdd:cd21184    78 PEDMVSPNVDELSVMTYLSY 97
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1028-1866 5.38e-22

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 105.52  E-value: 5.38e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1028 LRSELELTLGKLEQVRSLSaiylEKLKTISLVIRSTQGAeeVLKTHEEQLKEAQAvpATLQELEATKASLKKLRAQAEAQ 1107
Cdd:TIGR02168  194 ILNELERQLKSLERQAEKA----ERYKELKAELRELELA--LLVLRLEELREELE--ELQEELKEAEEELEELTAELQEL 265
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1108 QPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLSAW 1187
Cdd:TIGR02168  266 EEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEK 345
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1188 LQDAKRRQEQIQAVPIANC----------QAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQ 1257
Cdd:TIGR02168  346 LEELKEELESLEAELEELEaeleelesrlEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEE 425
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1258 LEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQyikfISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ 1337
Cdd:TIGR02168  426 LLKKLEEAELKELQAELEELEEELEELQEELERLEEALEE----LREELEEAEQALDAAERELAQLQARLDSLERLQENL 501
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1338 RQLAEAHAQAKAQAELEAQELQRRMQE-EVARREEAAVDAQQQKR----------SIQEELQHLRQSSE------AEIQA 1400
Cdd:TIGR02168  502 EGFSEGVKALLKNQSGLSGILGVLSELiSVDEGYEAAIEAALGGRlqavvvenlnAAKKAIAFLKQNELgrvtflPLDSI 581
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1401 KAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAea 1480
Cdd:TIGR02168  582 KGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALELAKKLRPGYRIVTLDGDLVRPGG-- 659
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1481 eLALRVKAEAEAAREKQRalQALDELRLQAEEAERRLRQAEAE--RARQVQVALETAQRSAEVELQSKRASFAEKTAQLE 1558
Cdd:TIGR02168  660 -VITGGSAKTNSSILERR--REIEELEEKIEELEEKIAELEKAlaELRKELEELEEELEQLRKELEELSRQISALRKDLA 736
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1559 RtLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERwQLKANEALRLRLQAeEVAQQKSLAQADAEKQKEEAEREA 1638
Cdd:TIGR02168  737 R-LEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEE-ELAEAEAEIEELEA-QIEQLKEELKALREALDELRAELT 813
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1639 RRRGKAEEQAVRQRELaEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQEL 1718
Cdd:TIGR02168  814 LLNEEAANLRERLESL-ERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALL 892
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1719 EAELAKVRAEMEVLL--ASKARAE-EESRSTSEKSKQRLEAEAGRFRELAEE-AARLRALAEEAKRQRQLAEEDAARQRA 1794
Cdd:TIGR02168  893 RSELEELSEELRELEskRSELRRElEELREKLAQLELRLEGLEVRIDNLQERlSEEYSLTLEEAEALENKIEDDEEEARR 972
                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675251  1795 EAERvLTEKLAAISEATRLkteaeiALKEKEAENERLRRLAEdeafqrrrleeqaalHKADIEERLAQLRKA 1866
Cdd:TIGR02168  973 RLKR-LENKIKELGPVNLA------AIEEYEELKERYDFLTA---------------QKEDLTEAKETLEEA 1022
SH3_10 pfam17902
SH3 domain; This entry represents an SH3 domain.
758-824 7.16e-22

SH3 domain; This entry represents an SH3 domain.


Pssm-ID: 407754  Cd Length: 65  Bit Score: 91.55  E-value: 7.16e-22
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251   758 QLKPRNpaHPVRGHVPLIAVCDYKQVEVTVHKGDQCQLVGPAQPSHWKVLSGSSSEAAVPSVCFLVP 824
Cdd:pfam17902    1 PLKQRR--SPVTRPIPVKALCDYKQGEVTVEKGEECTLLDNSDREKWKVQTSSGVEKLVPSVCFLIP 65
CH_FLNB_rpt1 cd21309
first calponin homology (CH) domain found in filamin-B (FLN-B) and similar proteins; Filamin-B ...
10-115 7.20e-22

first calponin homology (CH) domain found in filamin-B (FLN-B) and similar proteins; Filamin-B (FLN-B) is also called ABP-278, ABP-280 homolog, actin-binding-like protein, beta-filamin, filamin homolog 1 (Fh1), filamin-3, thyroid autoantigen, truncated actin-binding protein, or truncated ABP. It connects cell membrane constituents to the actin cytoskeleton. It may promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. It anchors various transmembrane proteins to the actin cytoskeleton. FLN-B contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409158  Cd Length: 131  Bit Score: 94.38  E-value: 7.20e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   10 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---EKGRMRFHKLQNVQIALDYLRHRQVKLV 86
Cdd:cd21309    16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRkyhQRPTFRQMQLENVSVALEFLDRESIKLV 95
                          90       100
                  ....*....|....*....|....*....
gi 254675251   87 NIRNDDIADGNPKLTLGLIWTIILHFQIS 115
Cdd:cd21309    96 SIDSKAIVDGNLKLILGLVWTLILHYSIS 124
CH_FLNA_rpt1 cd21308
first calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins; Filamin-A ...
10-115 7.67e-22

first calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins; Filamin-A (FLN-A) is also called actin-binding protein 280 (ABP-280), alpha-filamin, endothelial actin-binding protein, filamin-1, or non-muscle filamin. It promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. It also anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. FLN-A contains two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409157  Cd Length: 129  Bit Score: 94.00  E-value: 7.67e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   10 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---EKGRMRFHKLQNVQIALDYLRHRQVKLV 86
Cdd:cd21308    19 KIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQKKMHRkhnQRPTFRQMQLENVSVALEFLDRESIKLV 98
                          90       100
                  ....*....|....*....|....*....
gi 254675251   87 NIRNDDIADGNPKLTLGLIWTIILHFQIS 115
Cdd:cd21308    99 SIDSKAIVDGNLKLILGLIWTLILHYSIS 127
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1596-2393 1.37e-21

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 104.41  E-value: 1.37e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1596 LERWQLKANEalrLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA 1675
Cdd:COG1196   188 LERLEDLLEE---LEKQLEKLERQAEKAERYQELKAELRELELALLLAKLKELRKELEELEEELSRLEEELEELQEELEE 264
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1676 AEQELIRLRAEteqgeqqRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEK---SKQ 1752
Cdd:COG1196   265 AEKEIEELKSE-------LEELREELEELQEELLELKEEIEELEGEISLLRERLEELENELEELEERLEELKEKieaLKE 337
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1753 RLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLR 1832
Cdd:COG1196   338 ELEERETLLEELEQLLAELEEAKEELEEKLSALLEELEELFEALREELAELEAELAEIRNELEELKREIESLEERLERLS 417
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1833 RLAEDEAFQRRRLEEQAALHKADIEERlaqlrkasESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELE 1912
Cdd:COG1196   418 ERLEDLKEELKELEAELEELQTELEEL--------NEELEELEEQLEELRDRLKELERELAELQEELQRLEKELSSLEAR 489
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1913 LGRIRSNAEDTMRSKEQAEleaARQRQLAAEEEQRRREAEERVQRSLAAE--------------EEAARQRKVALEEVER 1978
Cdd:COG1196   490 LDRLEAEQRASQGVRAVLE---ALESGLPGVYGPVAELIKVKEKYETALEaalgnrlqavvvenEEVAKKAIEFLKENKA 566
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1979 LKAKVEEARRLRERAEQESARQLQLAQEAAQ--KRLQAEEKAHAFVVQQ----------REEELQQTLQQEQNMLDRLRS 2046
Cdd:COG1196   567 GRATFLPLDRIKPLRSLKSDAAPGFLGLASDliDFDPKYEPAVRFVLGDtlvvddleqaRRLARKLRIKYRIVTLDGDLV 646
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2047 EAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQ 2126
Cdd:COG1196   647 EPSGSITGGSRNKRSSLAQKRELKELEEELAELEAQLEKLEEELKSLKNELRSLEDLLEELRRQLEELERQLEELKRELA 726
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2127 AADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELG 2206
Cdd:COG1196   727 ALEEELEQLQSRLEELEEELEELEEELEELQERLEELEEELESLEEALAKLKEEIEELEEKRQALQEELEELEEELEEAE 806
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2207 KLKARIEAEnRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK-------E 2279
Cdd:COG1196   807 RRLDALERE-LESLEQRRERLEQEIEELEEEIEELEEKLDELEEELEELEKELEELKEELEELEAEKEELEDelkeleeE 885
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2280 KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMS--------------- 2344
Cdd:COG1196   886 KEELEEELRELESELAELKEEIEKLRERLEELEAKLERLEVELPELEEELEEEYEDTLETELEREierleeeiealgpvn 965
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|...
gi 254675251 2345 ----AEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2393
Cdd:COG1196   966 lraiEEYEEVEERYEELKSQREDLEEAKEKLLEVIEELDKEKRERFKETFDKI 1018
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1605-2431 1.90e-21

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 103.64  E-value: 1.90e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1605 EALRLRLQAEEVAQ-QKSLAQADAEKQKEEAEREARRRGKAE-EQAVRQRELAEQELEKQRQLAEGTAQQRLAA----EQ 1678
Cdd:COG1196   223 RELELALLLAKLKElRKELEELEEELSRLEEELEELQEELEEaEKEIEELKSELEELREELEELQEELLELKEEieelEG 302
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1679 ELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA 1758
Cdd:COG1196   303 EISLLRERLEELENELEELEERLEELKEKIEALKEELEERETLLEELEQLLAELEEAKEELEEKLSALLEELEELFEALR 382
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1759 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDE 1838
Cdd:COG1196   383 EELAELEAELAEIRNELEELKREIESLEERLERLSERLEDLKEELKELEAELEELQTELEELNEELEELEEQLEELRDRL 462
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1839 AFQRRRLEEqaalhkadIEERLAQLRKASESELERQKGLveDTLRQRRQVEEEIMALKVSFEKAAAGKAeleLELGRIrs 1918
Cdd:COG1196   463 KELERELAE--------LQEELQRLEKELSSLEARLDRL--EAEQRASQGVRAVLEALESGLPGVYGPV---AELIKV-- 527
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1919 naedtmRSKEQAELEAARQRQLAAEeeqrrreaeervqrsLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESA 1998
Cdd:COG1196   528 ------KEKYETALEAALGNRLQAV---------------VVENEEVAKKAIEFLKENKAGRATFLPLDRIKPLRSLKSD 586
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1999 RQLQLAQEAAQ--KRLQAEEKAHAFVVQQ----------REEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAE 2066
Cdd:COG1196   587 AAPGFLGLASDliDFDPKYEPAVRFVLGDtlvvddleqaRRLARKLRIKYRIVTLDGDLVEPSGSITGGSRNKRSSLAQK 666
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2067 REAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQK 2146
Cdd:COG1196   667 RELKELEEELAELEAQLEKLEEELKSLKNELRSLEDLLEELRRQLEELERQLEELKRELAALEEELEQLQSRLEELEEEL 746
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2147 AQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAEnRALILRDKDN 2226
Cdd:COG1196   747 EELEEELEELQERLEELEEELESLEEALAKLKEEIEELEEKRQALQEELEELEEELEEAERRLDALERE-LESLEQRRER 825
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2227 TQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK-------EKMQAVQEATRLKAEAELLQQ 2299
Cdd:COG1196   826 LEQEIEELEEEIEELEEKLDELEEELEELEKELEELKEELEELEAEKEELEDelkeleeEKEELEEELRELESELAELKE 905
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2300 QKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEmsAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEig 2379
Cdd:COG1196   906 EIEKLRERLEELEAKLERLEVELPELEEELEEEYEDTLETELE--REIERLEEEIEALGPVNLRAIEEYEEVEERYEE-- 981
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|..
gi 254675251 2380 eklhrtelatqekvtlvqtLEIQRQQSDHDAERLREAIAELEREKEKLKQEA 2431
Cdd:COG1196   982 -------------------LKSQREDLEEAKEKLLEVIEELDKEKRERFKET 1014
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1511-2385 2.93e-21

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 103.21  E-value: 2.93e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1511 EEAERRLRQAEAERARqVQVALETAQRSAE-VELQSKRAS-FAEKTAQLERTlqEEHVTVAQLREEAERRAQQQAeaera 1588
Cdd:TIGR02168  175 KETERKLERTRENLDR-LEDILNELERQLKsLERQAEKAErYKELKAELREL--ELALLVLRLEELREELEELQE----- 246
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1589 reeaerelerwQLKANEALRLRLQAEEVAQQKSLAQADAEKQKeeaerearrrgKAEEQAVRQRELAE-----QELEKQR 1663
Cdd:TIGR02168  247 -----------ELKEAEEELEELTAELQELEEKLEELRLEVSE-----------LEEEIEELQKELYAlaneiSRLEQQK 304
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1664 QLAEgtaQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEvllaskaraeeES 1743
Cdd:TIGR02168  305 QILR---ERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELE-----------EL 370
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1744 RSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEK-LAAISEATRLKTEAEIALK 1822
Cdd:TIGR02168  371 ESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLeEAELKELQAELEELEEELE 450
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1823 EKEAENERLRRLAEdEAFQRRRLEEQAALHKADIEERLAQLRKASESELERQKGLVED--TLRQRRQVEEEIMALKVSFE 1900
Cdd:TIGR02168  451 ELQEELERLEEALE-ELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGvkALLKNQSGLSGILGVLSELI 529
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1901 KAAAG-KAELELELGRIRSNAedTMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERL 1979
Cdd:TIGR02168  530 SVDEGyEAAIEAALGGRLQAV--VVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDL 607
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1980 KAKVEEARRL----------RERAEQESARQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQNMLDRLRSEAE 2049
Cdd:TIGR02168  608 VKFDPKLRKAlsyllggvlvVDDLDNALELAKKLRPGYRIVTLDGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIE 687
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2050 AARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAAD 2129
Cdd:TIGR02168  688 ELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELE 767
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2130 AEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLK 2209
Cdd:TIGR02168  768 ERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQI 847
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2210 ARIEAENRALILRDKDntqrfLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATR 2289
Cdd:TIGR02168  848 EELSEDIESLAAEIEE-----LEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELRE 922
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2290 LKAEAEL----LQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEaERQRQLEMS------------AEAERLKLR 2353
Cdd:TIGR02168  923 KLAQLELrlegLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEAR-RRLKRLENKikelgpvnlaaiEEYEELKER 1001
                          890       900       910
                   ....*....|....*....|....*....|..
gi 254675251  2354 MAEMSRAQaraeEDAQRFRKQAEEIGEKLHRT 2385
Cdd:TIGR02168 1002 YDFLTAQK----EDLTEAKETLEEAIEEIDRE 1029
CH_MICAL2_3-like cd21195
calponin homology (CH) domain found in molecule interacting with CasL protein 2 (MICAL-2), ...
131-228 1.08e-20

calponin homology (CH) domain found in molecule interacting with CasL protein 2 (MICAL-2), MICAL-3, and similar proteins; Molecule interacting with CasL protein (MICAL) is a large, multidomain, cytosolic protein with a single LIM domain, a calponin homology (CH) domain and a flavoprotein monooxygenase (MO) domain. In Drosophila, MICAL is expressed in axons, interacts with the neuronal A (PlexA) receptor and is required for Semaphorin 1a (Sema-1a)-PlexA-mediated repulsive axon guidance. The LIM and CH domains mediate interactions with the cytoskeleton, cytoskeletal adaptor proteins, and other signaling proteins. The flavoprotein MO is required for semaphorin-plexin repulsive axon guidance during axonal pathfinding in the Drosophila neuromuscular system. In addition, MICAL functions to interact with Rab13 and Rab8 to coordinate the assembly of tight junctions and adherens junctions in epithelial cells. Thus, MICAL is also called junctional Rab13-binding protein (JRAB). Members of this family, which includes MICAL-2, MICAL-3, and similar proteins, contain one CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409044 [Multi-domain]  Cd Length: 110  Bit Score: 90.10  E-value: 1.08e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  131 KLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD-PEDV 209
Cdd:cd21195     8 KLLTWCQQQTEGYQHVNVTDLTTSWRSGLALCAIIHRFRPELINFDSLNEDDAVENNQLAFDVAEREFGIPPVTTgKEMA 87
                          90
                  ....*....|....*....
gi 254675251  210 DVPQPDEKSIITYVSSLYD 228
Cdd:cd21195    88 SAQEPDKLSMVMYLSKFYE 106
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1295-2044 1.17e-20

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 101.33  E-value: 1.17e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1295 TSQYIKFISETLRRMEE-EERLAEQQraEERERLAEVEAALEKQRQLAEAHAQAKAQAE-LEAQELQRRMQEEVARREEA 1372
Cdd:COG1196   167 VSKYKERKEEAERKLERtEENLERLE--DLLEELEKQLEKLERQAEKAERYQELKAELReLELALLLAKLKELRKELEEL 244
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1373 AVDAQQQKRSIqEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEA 1452
Cdd:COG1196   245 EEELSRLEEEL-EELQEELEEAEKEIEELKSELEELREELEELQEELLELKEEIEELEGEISLLRERLEELENELEELEE 323
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1453 QKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVA- 1531
Cdd:COG1196   324 RLEELKEKIEALKEELEERETLLEELEQLLAELEEAKEELEEKLSALLEELEELFEALREELAELEAELAEIRNELEELk 403
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1532 ------------LETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERW 1599
Cdd:COG1196   404 reiesleerlerLSERLEDLKEELKELEAELEELQTELEELNEELEELEEQLEELRDRLKELERELAELQEELQRLEKEL 483
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1600 QLKANEALRLRLQAEEVAQQKSLAQADAE---------------KQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQ 1664
Cdd:COG1196   484 SSLEARLDRLEAEQRASQGVRAVLEALESglpgvygpvaelikvKEKYETALEAALGNRLQAVVVENEEVAKKAIEFLKE 563
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1665 LAEGTA------------QQRLAAEQELIRLRAETEQGEQQRQLLEEelARLQHEATAATQKRQELEAELAKVRAEM--- 1729
Cdd:COG1196   564 NKAGRAtflpldrikplrSLKSDAAPGFLGLASDLIDFDPKYEPAVR--FVLGDTLVVDDLEQARRLARKLRIKYRIvtl 641
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1730 --EVLLAS--------KARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEedaaRQRAEAERV 1799
Cdd:COG1196   642 dgDLVEPSgsitggsrNKRSSLAQKRELKELEEELAELEAQLEKLEEELKSLKNELRSLEDLLEELR----RQLEELERQ 717
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1800 LTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAlHKADIEERLAQLRKASESELERQKGLVE 1879
Cdd:COG1196   718 LEELKRELAALEEELEQLQSRLEELEEELEELEEELEELQERLEELEEELE-SLEEALAKLKEEIEELEEKRQALQEELE 796
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1880 DTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQRQlaaeeeqRRREAEERVQRSL 1959
Cdd:COG1196   797 ELEEELEEAERRLDALERELESLEQRRERLEQEIEELEEEIEELEEKLDELEEELEELEK-------ELEELKEELEELE 869
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1960 AAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQN 2039
Cdd:COG1196   870 AEKEELEDELKELEEEKEELEEELRELESELAELKEEIEKLRERLEELEAKLERLEVELPELEEELEEEYEDTLETELER 949

                  ....*
gi 254675251 2040 MLDRL 2044
Cdd:COG1196   950 EIERL 954
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1090-1892 1.31e-20

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 100.90  E-value: 1.31e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1090 LEATKASLKKLRAQAEAQQPvFNTLRDELRgaqevgerlqqrhgerDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQ 1169
Cdd:TIGR02168  195 LNELERQLKSLERQAEKAER-YKELKAELR----------------ELELALLVLRLEELREELEELQEELKEAEEELEE 257
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1170 LGRQLRYYRESADPLSAWLQDAKRRQEQIQAV------PIANC----QAAREQLRQEKALLEEIERHGEKVEECQKFAKQ 1239
Cdd:TIGR02168  258 LTAELQELEEKLEELRLEVSELEEEIEELQKElyalanEISRLeqqkQILRERLANLERQLEELEAQLEELESKLDELAE 337
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1240 YINAIKDYELQLITYKAQLEpvASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEE-ERLAEQ 1318
Cdd:TIGR02168  338 ELAELEEKLEELKEELESLE--AELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARlERLEDR 415
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1319 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLR------Q 1392
Cdd:TIGR02168  416 RERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQarldslE 495
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1393 SSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAE----GELQALRARAEEAEAQKRQAQEEAERLRR-- 1466
Cdd:TIGR02168  496 RLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEGYEAAIEaalgGRLQAVVVENLNAAKKAIAFLKQNELGRVtf 575
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1467 --------QVQDESQRKRQAEAELALRVKAEAEAAREK-QRALQALDELRLQAEEAERRLRQAEAERARQVQVALE---- 1533
Cdd:TIGR02168  576 lpldsikgTEIQGNDREILKNIEGFLGVAKDLVKFDPKlRKALSYLLGGVLVVDDLDNALELAKKLRPGYRIVTLDgdlv 655
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1534 ----------TAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1603
Cdd:TIGR02168  656 rpggvitggsAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDL 735
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1604 NEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRL 1683
Cdd:TIGR02168  736 ARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLL 815
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1684 RAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE 1763
Cdd:TIGR02168  816 NEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSE 895
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1764 LAEEAARLRALAEEAKRQRQLAEE------DAARQRAEAERVLTEKLAAISEatRLKTEAEIALkEKEAENERLRRLAED 1837
Cdd:TIGR02168  896 LEELSEELRELESKRSELRRELEElreklaQLELRLEGLEVRIDNLQERLSE--EYSLTLEEAE-ALENKIEDDEEEARR 972
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251  1838 EAFQ-RRRLEEQAALHKADIEErlaqLRKASE--SELERQKglvEDTLRQRRQVEEEI 1892
Cdd:TIGR02168  973 RLKRlENKIKELGPVNLAAIEE----YEELKEryDFLTAQK---EDLTEAKETLEEAI 1023
PTZ00121 PTZ00121
MAEBL; Provisional
1821-2573 2.70e-20

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 100.22  E-value: 2.70e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1821 LKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKASESE-LERQKGLVEDTlrqrrqveeeimalkvsf 1899
Cdd:PTZ00121 1042 LKEKDIIDEDIDGNHEGKAEAKAHVGQDEGLKPSYKDFDFDAKEDNRADEaTEEAFGKAEEA------------------ 1103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1900 EKAAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQrqlaaeeeqrrreaeervqrslaaEEEAARQRKVALEEVERl 1979
Cdd:PTZ00121 1104 KKTETGKAEEARKAEEAKKKAEDARKAEEARKAEDARK------------------------AEEARKAEDAKRVEIAR- 1158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1980 kaKVEEARRLRERAEQESARQLQLAQEAAQKRlQAEEKAHAFVVQQREEElqqtlqqeqnmldRLRSEAEAARRAAEEAE 2059
Cdd:PTZ00121 1159 --KAEDARKAEEARKAEDAKKAEAARKAEEVR-KAEELRKAEDARKAEAA-------------RKAEEERKAEEARKAED 1222
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2060 EAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQ--KQAADAEMEKHKK 2137
Cdd:PTZ00121 1223 AKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEekKKADEAKKAEEKK 1302
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2138 FAEQtLRQKAQVEQELTTLRLQLEETDHQKSILDE--ELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAE 2215
Cdd:PTZ00121 1303 KADE-AKKKAEEAKKADEAKKKAEEAKKKADAAKKkaEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKAD 1381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2216 NraliLRDKDNTQRfleeEAEKMKQVAEEAARLSVAAQEAARLRQLAEEdlaqqralaekmLKEKMQAVQEATRLKAEAE 2295
Cdd:PTZ00121 1382 A----AKKKAEEKK----KADEAKKKAEEDKKKADELKKAAAAKKKADE------------AKKKAEEKKKADEAKKKAE 1441
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2296 LLQQQKELAQ--EQARRLQEDKEQmAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKlrmAEMSRAQARAEEDAQRFRK 2373
Cdd:PTZ00121 1442 EAKKADEAKKkaEEAKKAEEAKKK-AEEAKKADEAKKKAEEAKKADEAKKKAEEAKKK---ADEAKKAAEAKKKADEAKK 1517
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2374 QAE-EIGEKLHRTELATQEKvtlvqtlEIQRQQSDHDAERLREAiAELEREKEKLKQEAKllqlKSEEMQTVQQEQILQE 2452
Cdd:PTZ00121 1518 AEEaKKADEAKKAEEAKKAD-------EAKKAEEKKKADELKKA-EELKKAEEKKKAEEA----KKAEEDKNMALRKAEE 1585
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2453 TQALQKSFLSEKDSLLQrerfiEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMAsmEEARR----RQREAE 2528
Cdd:PTZ00121 1586 AKKAEEARIEEVMKLYE-----EEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEA--EEKKKaeelKKAEEE 1658
                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*.
gi 254675251 2529 EGVRRKQEELQHLEQQRQQQEKLLAEENQRLR-ERLQRLEEEHRAA 2573
Cdd:PTZ00121 1659 NKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAaEALKKEAEEAKKA 1704
CH_EHBP1L1 cd21255
calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar ...
127-226 4.23e-20

calponin homology (CH) domain found in EH domain-binding protein 1-like protein 1 and similar proteins; EHBP1L1 may act as Rab effector protein and play a role in vesicle trafficking. It coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells. Members of this subfamily contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409104  Cd Length: 105  Bit Score: 88.31  E-value: 4.23e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERdLGVTRLLDP 206
Cdd:cd21255     1 SSSQSLLEWCQEVTAGYRGVRVTNFTTSWRNGLAFCAILHHFHPDLVDYESLDPLDIKENNKKAFEAFAS-LGVPRLLEP 79
                          90       100
                  ....*....|....*....|.
gi 254675251  207 ED-VDVPQPDEKSIITYVSSL 226
Cdd:cd21255    80 ADmVLLPIPDKLIVMTYLCQL 100
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
1288-1848 7.05e-20

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 223496 [Multi-domain]  Cd Length: 908  Bit Score: 98.29  E-value: 7.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1288 YSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVA 1367
Cdd:COG0419   191 EGQLSELLEDIEDLLEALEEELKELKKLEEIQEEQEEEELEQEIEALEERLAELEEEKERLEELKARLLEIESLELEALK 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1368 RREEAAVDAQQQKRSIQEELQHL--RQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRA 1445
Cdd:COG0419   271 IREEELRELERLLEELEEKIERLeeLEREIEELEEELEGLRALLEELEELLEKLKSLEERLEKLEEKLEKLESELEELAE 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1446 RAEEA----EAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAE 1521
Cdd:COG0419   351 EKNELakllEERLKELEERLEELEKELEKALERLKQLEEAIQELKEELAELSAALEEIQEELEELEKELEELERELEELE 430
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1522 AERArqvqvALETAQRSAEVELQSKR--ASFAEKTAQLERTLQEEHVtvaqlreEAERRAQQQAEAERAREEAERELERW 1599
Cdd:COG0419   431 EEIK-----KLEEQINQLESKELMIAelAGAGEKCPVCGQELPEEHE-------KELLELYELELEELEEELSREKEEAE 498
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1600 QLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEgTAQQRLAAEQE 1679
Cdd:COG0419   499 LREEIEELEKELRELEEELIELLELEEALKEELEEKLEKLENLLEELEELKEKLQLQQLKEELRQLED-RLQELKELLEE 577
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1680 LIRLRaeteqgeqqrqLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQrleaEAG 1759
Cdd:COG0419   578 LRLLR-----------TRKEELEELRERLKELKKKLKELEERLSQLEELLQSLELSEAENELEEAEEELESEL----EKL 642
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1760 RFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEA 1839
Cdd:COG0419   643 NLQAELEELLQAALEELEEKVEELEAEIRRELQRIENEEQLEEKLEELEQLEEELEQLREELEELLKKLGEIEQLIEELE 722

                  ....*....
gi 254675251 1840 FQRRRLEEQ 1848
Cdd:COG0419   723 SRKAELEEL 731
CH_SMTN-like cd21200
calponin homology (CH) domain found in the smoothelin family; The smoothelin family includes ...
127-227 1.37e-19

calponin homology (CH) domain found in the smoothelin family; The smoothelin family includes smoothelin and smoothelin-like proteins. Smoothelins are actin-binding cytoskeletal proteins that are abundantly expressed in healthy visceral (smoothelin-A) and vascular (smoothelin-B) smooth muscle. SMTNL1, also called calponin homology-associated smooth muscle protein (CHASM), plays a role in the regulation of contractile properties of both striated and smooth muscles. It can bind to calmodulin and tropomyosin. When it is unphosphorylated, SMTNL1 may inhibit myosin dephosphorylation. SMTNL2 is highly expressed in skeletal muscle and could be associated with differentiating myocytes. Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409049  Cd Length: 107  Bit Score: 86.63  E-value: 1.37e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDP 206
Cdd:cd21200     1 SIKQMLLEWCQAKTRGYEHVDITNFSSSWSDGMAFCALIHHFFPDAFDYSSLDPKNRRKNFELAFSTAEELADIAPLLEV 80
                          90       100
                  ....*....|....*....|...
gi 254675251  207 EDVDV--PQPDEKSIITYVSSLY 227
Cdd:cd21200    81 EDMVRmgNRPDWKCVFTYVQSLY 103
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1491-2431 1.42e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 97.82  E-value: 1.42e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1491 EAAREKQRALQALDELRLQAEEAERRL----RQAE-AERARQVQVALETAQRSAEV-ELQSKRASFAEKTAQLERTLQEE 1564
Cdd:TIGR02168  176 ETERKLERTRENLDRLEDILNELERQLksleRQAEkAERYKELKAELRELELALLVlRLEELREELEELQEELKEAEEEL 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1565 HVTVAQLREEAERraqqqaeaerareeaereLERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKeeaerearrrgka 1644
Cdd:TIGR02168  256 EELTAELQELEEK------------------LEELRLEVSELEEEIEELQKELYALANEISRLEQQK------------- 304
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1645 EEQAVRQRELAEQELEKQRQLAEgTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAK 1724
Cdd:TIGR02168  305 QILRERLANLERQLEELEAQLEE-LESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLET 383
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1725 VRAEMEVLLASKARAEEEsRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAErvLTEKL 1804
Cdd:TIGR02168  384 LRSKVAQLELQIASLNNE-IERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEE--LERLE 460
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1805 AAISEATRLKTEAEIALKEKEAENERLR-RLAEDEAFQRRRLEEQAALHKAdieerlaqlrKASESELERQKGLVEDTLR 1883
Cdd:TIGR02168  461 EALEELREELEEAEQALDAAERELAQLQaRLDSLERLQENLEGFSEGVKAL----------LKNQSGLSGILGVLSELIS 530
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1884 qrrqVEEEimalkvsFEKAaagkaeLELELGRIRSNAedTMRSKEQAELEAARQRQlaaeeeqrrreaeervqrslaaee 1963
Cdd:TIGR02168  531 ----VDEG-------YEAA------IEAALGGRLQAV--VVENLNAAKKAIAFLKQ------------------------ 567
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1964 eaARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEK---AHAFVVQQREEELQQTLQQEQNM 2040
Cdd:TIGR02168  568 --NELGRVTFLPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKALSyllGGVLVVDDLDNALELAKKLRPGY 645
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2041 ldRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQA 2120
Cdd:TIGR02168  646 --RIVTLDGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEE 723
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2121 ALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRv 2200
Cdd:TIGR02168  724 LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALR- 802
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2201 qmEELGKLKARIEAENRAL--ILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2278
Cdd:TIGR02168  803 --EALDELRAELTLLNEEAanLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLN 880
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2279 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRtLEAERQRQLEMSAEAERLKLRMAEms 2358
Cdd:TIGR02168  881 ERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEG-LEVRIDNLQERLSEEYSLTLEEAE-- 957
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2359 RAQARAEEDAQRFRKQAEEIGEKLHR----TELATQEKVTLVQTLE-IQRQQSDHDA--ERLREAIAELEREKEKLKQEA 2431
Cdd:TIGR02168  958 ALENKIEDDEEEARRRLKRLENKIKElgpvNLAAIEEYEELKERYDfLTAQKEDLTEakETLEEAIEEIDREARERFKDT 1037
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1474-2302 1.77e-19

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 97.48  E-value: 1.77e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1474 RKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVAL------ETAQRSAEVELQSKR 1547
Cdd:COG1196   173 RKEEAERKLERTEENLERLEDLLEELEKQLEKLERQAEKAERYQELKAELRELELALLLaklkelRKELEELEEELSRLE 252
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1548 ASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQADA 1627
Cdd:COG1196   253 EELEELQEELEEAEKEIEELKSELEELREELEELQEELLELKEEIEELEGEISLLRERLEELENELEELEERLEELKEKI 332
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1628 EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHE 1707
Cdd:COG1196   333 EALKEELEERETLLEELEQLLAELEEAKEELEEKLSALLEELEELFEALREELAELEAELAEIRNELEELKREIESLEER 412
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1708 ATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1787
Cdd:COG1196   413 LERLSERLEDLKEELKELEAELEELQTELEELNEELEELEEQLEELRDRLKELERELAELQEELQRLEKELSSLEARLDR 492
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1788 DAARQRA---------EAERVLTEKLAAISEATRLKTEAEIAL------------------------KEKEAENERLRRL 1834
Cdd:COG1196   493 LEAEQRAsqgvravleALESGLPGVYGPVAELIKVKEKYETALeaalgnrlqavvveneevakkaieFLKENKAGRATFL 572
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1835 AEDEAFQRRRLEEQAALHKADIEERLAQLRKASESELER--QKGLVEDTLRQRRQVEEEIMALK--VSFEKAaagkaelE 1910
Cdd:COG1196   573 PLDRIKPLRSLKSDAAPGFLGLASDLIDFDPKYEPAVRFvlGDTLVVDDLEQARRLARKLRIKYriVTLDGD-------L 645
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1911 LELGRIRSNAEDTMRSKEQAELEAAR-QRQLaaeeeqrrreaeERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRL 1989
Cdd:COG1196   646 VEPSGSITGGSRNKRSSLAQKRELKElEEEL------------AELEAQLEKLEEELKSLKNELRSLEDLLEELRRQLEE 713
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1990 RERAEQESARQLQlAQEAAQKRLQAEEKAhafvVQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREA 2069
Cdd:COG1196   714 LERQLEELKRELA-ALEEELEQLQSRLEE----LEEELEELEEELEELQERLEELEEELESLEEALAKLKEEIEELEEKR 788
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2070 AQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQV 2149
Cdd:COG1196   789 QALQEELEELEEELEEAERRLDALERELESLEQRRERLEQEIEELEEEIEELEEKLDELEEELEELEKELEELKEELEEL 868
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2150 EQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELgklkariEAENRALILRDKDNTQR 2229
Cdd:COG1196   869 EAEKEELEDELKELEEEKEELEEELRELESELAELKEEIEKLRERLEELEAKLERL-------EVELPELEEELEEEYED 941
                         810       820       830       840       850       860       870
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 2230 FLEEEAEKMKQVAEEaarlsvaaqEAARLRQ---LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE 2302
Cdd:COG1196   942 TLETELEREIERLEE---------EIEALGPvnlRAIEEYEEVEERYEELKSQREDLEEAKEKLLEVIEELDKEKR 1008
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1403-2219 2.26e-19

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 97.05  E-value: 2.26e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1403 QQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEG-----------ELQALRARAEEAEAQKRQAQEEAERLRRQVQDE 1471
Cdd:TIGR02168  179 RKLERTRENLDRLEDILNELERQLKSLERQAEKAERykelkaelrelELALLVLRLEELREELEELQEELKEAEEELEEL 258
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1472 SQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEveLQSKRASFA 1551
Cdd:TIGR02168  259 TAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEE--LESKLDELA 336
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1552 EKTAQLERTLQEEHVTVAQLREEaerraqqqaeaerareeaereLERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQK 1631
Cdd:TIGR02168  337 EELAELEEKLEELKEELESLEAE---------------------LEELEAELEELESRLEELEEQLETLRSKVAQLELQI 395
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1632 EEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEgtAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAA 1711
Cdd:TIGR02168  396 ASLNNEIERLEARLERLEDRRERLQQEIEELLKKLE--EAELKELQAELEELEEELEELQEELERLEEALEELREELEEA 473
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1712 TQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSE--KSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLA---- 1785
Cdd:TIGR02168  474 EQALDAAERELAQLQARLDSLERLQENLEGFSEGVKAllKNQSGLSGILGVLSELISVDEGYEAAIEAALGGRLQAvvve 553
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1786 EEDAARQRAEAERVLTEKLAAISEATRLKteaeialkEKEAENERLRRLAEDEAFQR--RRLEEQAALHKADIEERLAQL 1863
Cdd:TIGR02168  554 NLNAAKKAIAFLKQNELGRVTFLPLDSIK--------GTEIQGNDREILKNIEGFLGvaKDLVKFDPKLRKALSYLLGGV 625
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1864 RKASEselerqkglVEDTLRQRRQVEEEIM-------------ALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQA 1930
Cdd:TIGR02168  626 LVVDD---------LDNALELAKKLRPGYRivtldgdlvrpggVITGGSAKTNSSILERRREIEELEEKIEELEEKIAEL 696
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1931 ELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQK 2010
Cdd:TIGR02168  697 EKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEE 776
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2011 RLQAEEKAHAfvVQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKqsaeeqa 2090
Cdd:TIGR02168  777 LAEAEAEIEE--LEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQI------- 847
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2091 QAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSIL 2170
Cdd:TIGR02168  848 EELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQL 927
                          810       820       830       840
                   ....*....|....*....|....*....|....*....|....*....
gi 254675251  2171 DEELQRLKAEVteaARQRSQVEEElfsVRVQMEELGKLKARIEAENRAL 2219
Cdd:TIGR02168  928 ELRLEGLEVRI---DNLQERLSEE---YSLTLEEAEALENKIEDDEEEA 970
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The ...
1438-2332 2.95e-19

RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 96.58  E-value: 2.95e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1438 GELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR-QAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERR 1516
Cdd:pfam02463  163 AGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKlKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLL 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1517 LRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHvtvaqlreeaeRRAQQQAEAERAREEAEREL 1596
Cdd:pfam02463  243 QELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLL-----------AKEEEELKSELLKLERRKVD 311
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1597 ERWQLKANEALRLRLQAEEVAQQKSLAQAdaEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1676
Cdd:pfam02463  312 DEEKLKESEKEKKKAEKELKKEKEEIEEL--EKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSA 389
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1677 EQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEA 1756
Cdd:pfam02463  390 AKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKK 469
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1757 EagrFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAE 1836
Cdd:pfam02463  470 S---EDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAIS 546
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1837 DEAFQRRRLEEQAALHKADIEERLAQLRKASESeLERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRI 1916
Cdd:pfam02463  547 TAVIVEVSATADEVEERQKLVRALTELPLGARK-LRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVV 625
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1917 RSNAEDTMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQE 1996
Cdd:pfam02463  626 EGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKE 705
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1997 SARQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQV 2076
Cdd:pfam02463  706 QREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEK 785
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2077 EEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTL 2156
Cdd:pfam02463  786 LKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITK 865
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2157 RLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAE 2236
Cdd:pfam02463  866 EELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEA 945
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2237 KMKQVAEEAarlsvaaqeaarLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2316
Cdd:pfam02463  946 DEKEKEENN------------KEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIE 1013
                          890
                   ....*....|....*.
gi 254675251  2317 QMAQQLVEETQGFQRT 2332
Cdd:pfam02463 1014 ETCQRLKEFLELFVSI 1029
CH_MICAL3 cd21251
calponin homology (CH) domain found in molecule interacting with CasL protein 3; MICAL-3 is a ...
123-228 3.19e-19

calponin homology (CH) domain found in molecule interacting with CasL protein 3; MICAL-3 is a [F-actin]-monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). MICAL-3 seems to act as a Rab effector protein and plays a role in vesicle trafficking. It is involved in exocytic vesicle tethering and fusion. MICAL3 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409100 [Multi-domain]  Cd Length: 111  Bit Score: 85.77  E-value: 3.19e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  123 SEDMTAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTR 202
Cdd:cd21251     1 NESVARSSKLLGWCQRQTEGYAGVNVTDLTMSWKSGLALCAIIHRYRPDLIDFDSLDEQDVEKNNQLAFDIAEKEFGISP 80
                          90       100
                  ....*....|....*....|....*..
gi 254675251  203 LLDPEDV-DVPQPDEKSIITYVSSLYD 228
Cdd:cd21251    81 IMTGKEMaSVGEPDKLSMVMYLTQFYE 107
CH smart00033
Calponin homology domain; Actin binding domains present in duplicate at the N-termini of ...
130-226 3.58e-19

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.


Pssm-ID: 214479 [Multi-domain]  Cd Length: 101  Bit Score: 85.45  E-value: 3.58e-19
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    130 EKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTN----LENLDQAFSVAERDLGVTRLLD 205
Cdd:smart00033    1 KTLLRWVNSLLAEYDKPPVTNFSSDLKDGVALCALLNSLSPGLVDKKKVAASLSrfkkIENINLALSFAEKLGGKVVLFE 80
                            90       100
                    ....*....|....*....|.
gi 254675251    206 PEDVDVPQPDEKSIITYVSSL 226
Cdd:smart00033   81 PEDLVEGPKLILGVIWTLISL 101
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
934-1756 4.62e-19

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 95.94  E-value: 4.62e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  934 LQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKDPAR---ECAQRIAEQQKAQAEVEGLGKGVARLSA 1010
Cdd:COG1196   202 LEKLERQAEKAERYQELKAELRELELALLLAKLKELRKELEELEEELSRleeELEELQEELEEAEKEIEELKSELEELRE 281
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1011 EAEKVLALpepSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKtislvirstQGAEEVLKTHEEQLKEAQAVPATLQEL 1090
Cdd:COG1196   282 ELEELQEE---LLELKEEIEELEGEISLLRERLEELENELEELE---------ERLEELKEKIEALKEELEERETLLEEL 349
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1091 EATKASLKKLRAQAEAQQPV---------------FNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQA 1155
Cdd:COG1196   350 EQLLAELEEAKEELEEKLSAlleeleelfealreeLAELEAELAEIRNELEELKREIESLEERLERLSERLEDLKEELKE 429
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1156 VLAQTDVRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAVpIANCQAAREQLRQEKALLEEIERHGEKVEECQK 1235
Cdd:COG1196   430 LEAELEELQTELEELNEELEELEEQLEELRDRLKELERELAELQEE-LQRLEKELSSLEARLDRLEAEQRASQGVRAVLE 508
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1236 FAKQYINAIKDYELQLITYKAQLEP----------------------------------VASPAKKPKVQSGSESVIQEY 1281
Cdd:COG1196   509 ALESGLPGVYGPVAELIKVKEKYETaleaalgnrlqavvveneevakkaieflkenkagRATFLPLDRIKPLRSLKSDAA 588
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1282 VDLRTRYSELTTLTSQYIKFISETLRR------MEEEERLAEQQRaeERERLAEVEAAL-EKQRQLAEAHAQAKAQ--AE 1352
Cdd:COG1196   589 PGFLGLASDLIDFDPKYEPAVRFVLGDtlvvddLEQARRLARKLR--IKYRIVTLDGDLvEPSGSITGGSRNKRSSlaQK 666
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1353 LEAQELQRRMQEEVARREEAavdaqqqkrsiqeelqhlrqssEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQ 1432
Cdd:COG1196   667 RELKELEEELAELEAQLEKL----------------------EEELKSLKNELRSLEDLLEELRRQLEELERQLEELKRE 724
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1433 RGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEE 1512
Cdd:COG1196   725 LAALEEELEQLQSRLEELEEELEELEEELEELQERLEELEEELESLEEALAKLKEEIEELEEKRQALQEELEELEEELEE 804
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1513 AERRLRQAEAERARQVQVALETAQRSAevELQSKRASFAEKTAQLERTLQEEHvtvaqlreeaerraqqqaeaerareea 1592
Cdd:COG1196   805 AERRLDALERELESLEQRRERLEQEIE--ELEEEIEELEEKLDELEEELEELE--------------------------- 855
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1593 eRELERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQkeeAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEgtaqQ 1672
Cdd:COG1196   856 -KELEELKEELEELEAEKEELEDELKELEEEKEELEEE---LRELESELAELKEEIEKLRERLEELEAKLERLEV----E 927
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1673 RLAAEQELIRLRAETEQGEQQRQL--LEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKS 1750
Cdd:COG1196   928 LPELEEELEEEYEDTLETELEREIerLEEEIEALGPVNLRAIEEYEEVEERYEELKSQREDLEEAKEKLLEVIEELDKEK 1007

                  ....*.
gi 254675251 1751 KQRLEA 1756
Cdd:COG1196  1008 RERFKE 1013
CH_NAV2-like cd21212
calponin homology (CH) domain found in neuron navigator (NAV) 2, NAV3, and similar proteins; ...
12-112 1.49e-18

calponin homology (CH) domain found in neuron navigator (NAV) 2, NAV3, and similar proteins; This family includes neuron navigator 2 (NAV2) and NAV3, both of which contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs. NAV2, also called helicase APC down-regulated 1 (HELAD1), pore membrane and/or filament-interacting-like protein 2 (POMFIL2), retinoic acid inducible in neuroblastoma 1 (RAINB1), Steerin-2 (STEERIN2), or Unc-53 homolog 2 (unc53H2), possesses 3' to 5' helicase activity and exonuclease activity. It is involved in neuronal development, specifically in the development of different sensory organs. NAV3, also called pore membrane and/or filament-interacting-like protein 1 (POMFIL1), Steerin-3 (STEERIN3), or Unc-53 homolog 3 (unc53H3), may regulate IL2 production by T-cells. It may be involved in neuron regeneration.


Pssm-ID: 409061  Cd Length: 105  Bit Score: 83.79  E-value: 1.49e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   12 QKKTFTKWVNKHLIKA--QRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGR--MRFHKLQNVQIALDYLRHRQVKLVN 87
Cdd:cd21212     1 EIEIYTDWANHYLEKGghKRIITDLQKDLGDGLTLVNLIEAVAGEKVPGIHSRpkTRAQKLENIQACLQFLAALGVDVQG 80
                          90       100
                  ....*....|....*....|....*
gi 254675251   88 IRNDDIADGNPKLTLGLIWTIILHF 112
Cdd:cd21212    81 ITAEDIVDGNLKAILGLFFSLSRYK 105
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1297-1893 1.50e-18

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 93.95  E-value: 1.50e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1297 QYIKFISETLRRMEEEERLAEQQR----------AEERERLAEVEAALEKQRQlaeahaqAKAQAELEAQELQRRMQEEV 1366
Cdd:PRK02224  213 SELAELDEEIERYEEQREQARETRdeadevleehEERREELETLEAEIEDLRE-------TIAETEREREELAEEVRDLR 285
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1367 ARREEaavdaqqqkrsIQEELQHLRQSSE---AEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQAL 1443
Cdd:PRK02224  286 ERLEE-----------LEEERDDLLAEAGlddADAEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDL 354
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1444 RARAEEaeaqkrqAQEEAERLrrqvqdesqrkrqaEAELalrvkAEAEAAREKQRAlqALDELRLQAEEAERRLRQAEae 1523
Cdd:PRK02224  355 EERAEE-------LREEAAEL--------------ESEL-----EEAREAVEDRRE--EIEELEEEIEELRERFGDAP-- 404
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1524 rarqvqVALETAQRSAEvELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELE--RWQL 1601
Cdd:PRK02224  405 ------VDLGNAEDFLE-ELREERDELREREAELEATLRTARERVEEAEALLEAGKCPECGQPVEGSPHVETIEedRERV 477
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1602 KANEALRLRLQAEEVAQQKSLAQADAEKqkeeaerearrrgKAEEQAVR---QRELAEQELEKQRQLAEGTAQQRLAAEQ 1678
Cdd:PRK02224  478 EELEAELEDLEEEVEEVEERLERAEDLV-------------EAEDRIERleeRREDLEELIAERRETIEEKRERAEELRE 544
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1679 ELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAeMEVLLASKARAEEESRSTSEKSKQRLEAEA 1758
Cdd:PRK02224  545 RAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLER-IRTLLAAIADAEDEIERLREKREALAELND 623
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1759 GRFRELAEEAARLRALAEEAKRQRqLAEEDAARQRAEaervltEKLAAISEATRLKTEAEIALKEK----EAENERLRRL 1834
Cdd:PRK02224  624 ERRERLAEKRERKRELEAEFDEAR-IEEAREDKERAE------EYLEQVEEKLDELREERDDLQAEigavENELEELEEL 696
                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251 1835 aedeafqRRRLEEQAALHkadieERLAQLRKASEsELERQKGLVEDTLRQRRQVEEEIM 1893
Cdd:PRK02224  697 -------RERREALENRV-----EALEALYDEAE-ELESMYGDLRAELRQRNVETLERM 742
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1047-1842 3.62e-18

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 92.86  E-value: 3.62e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1047 AIYLEKLKTISLVIRSTQGAEEVLKTHEEQLKEAQAVpaTLQELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGE 1126
Cdd:COG1196   228 ALLLAKLKELRKELEELEEELSRLEEELEELQEELEE--AEKEIEELKSELEELREELEELQEELLELKEEIEELEGEIS 305
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1127 RLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADP----LSAWLQDAKRRQEQIQAVp 1202
Cdd:COG1196   306 LLRERLEELENELEELEERLEELKEKIEALKEELEERETLLEELEQLLAELEEAKEEleekLSALLEELEELFEALREE- 384
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1203 IANCQAAREQLRQEKALLE-EIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAKKPKVQsgSESVIQEY 1281
Cdd:COG1196   385 LAELEAELAEIRNELEELKrEIESLEERLERLSERLEDLKEELKELEAELEELQTELEELNEELEELEEQ--LEELRDRL 462
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1282 VDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAE-AHAQAKAQAELEAQeLQR 1360
Cdd:COG1196   463 KELERELAELQEELQRLEKELSSLEARLDRLEAEQRASQGVRAVLEALESGLPGVYGPVAElIKVKEKYETALEAA-LGN 541
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1361 RMQEEVARREEAAVDAQQQKRSIQE------ELQHLRQSSEAEIQAKAQQV----------------------------- 1405
Cdd:COG1196   542 RLQAVVVENEEVAKKAIEFLKENKAgratflPLDRIKPLRSLKSDAAPGFLglasdlidfdpkyepavrfvlgdtlvvdd 621
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1406 -EAAERSRMRIEEEIRVVRLQLETTERQR---GGAEGELQALRARAEEAEaqkrqaqeeaerLRRQVQDESQRKRQAEAE 1481
Cdd:COG1196   622 lEQARRLARKLRIKYRIVTLDGDLVEPSGsitGGSRNKRSSLAQKRELKE------------LEEELAELEAQLEKLEEE 689
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1482 LalrvkaeAEAAREKQRALQALDELRLQAEEAERRLRQAEAERArqvqvaletAQRSAEVELQSKRASFAEKTAQLERTL 1561
Cdd:COG1196   690 L-------KSLKNELRSLEDLLEELRRQLEELERQLEELKRELA---------ALEEELEQLQSRLEELEEELEELEEEL 753
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1562 QEEHVTVAQLreeaerraqqqaeaerareeaERELERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRR 1641
Cdd:COG1196   754 EELQERLEEL---------------------EEELESLEEALAKLKEEIEELEEKRQALQEELEELEEELEEAERRLDAL 812
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1642 GKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAE 1721
Cdd:COG1196   813 ERELESLEQRRERLEQEIEELEEEIEELEEKLDELEEELEELEKELEELKEELEELEAEKEELEDELKELEEEKEELEEE 892
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1722 LAKVRAEMEVLLASKARAEEesRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAAR-----QRAEA 1796
Cdd:COG1196   893 LRELESELAELKEEIEKLRE--RLEELEAKLERLEVELPELEEELEEEYEDTLETELEREIERLEEEIEAlgpvnLRAIE 970
                         810       820       830       840
                  ....*....|....*....|....*....|....*....|....*..
gi 254675251 1797 E-RVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1842
Cdd:COG1196   971 EyEEVEERYEELKSQREDLEEAKEKLLEVIEELDKEKRERFKETFDK 1017
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
13-110 5.80e-18

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031  Cd Length: 103  Bit Score: 82.00  E-value: 5.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   13 KKTFTKWVNKHL-IKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPRE--KGRMRFHKLQNVQIALDYLRHRQV-KLVNI 88
Cdd:cd00014     1 EEELLKWINEVLgEELPVSITDLFESLRDGVLLCKLINKLSPGSIPKInkKPKSPFKKRENINLFLNACKKLGLpELDLF 80
                          90       100
                  ....*....|....*....|...
gi 254675251   89 RNDDI-ADGNPKLTLGLIWTIIL 110
Cdd:cd00014    81 EPEDLyEKGNLKKVLGTLWALAL 103
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
991-1527 7.80e-18

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 223496 [Multi-domain]  Cd Length: 908  Bit Score: 91.75  E-value: 7.80e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  991 QQKAQAEVEGLGKGVARLSAEAEKVLALPE-----PSPAAPTLRSELELTLGKLEQVRSLSA-IYLEKLKTISLVIRSTQ 1064
Cdd:COG0419   191 EGQLSELLEDIEDLLEALEEELKELKKLEEiqeeqEEEELEQEIEALEERLAELEEEKERLEeLKARLLEIESLELEALK 270
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1065 GAEEVLKTHEEQLKEAQAVPATLQELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRE 1144
Cdd:COG0419   271 IREEELRELERLLEELEEKIERLEELEREIEELEEELEGLRALLEELEELLEKLKSLEERLEKLEEKLEKLESELEELAE 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1145 RVTQLLERWQAvlaqtdvRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAVPIANCQAAREQLRQEKALLEEIE 1224
Cdd:COG0419   351 EKNELAKLLEE-------RLKELEERLEELEKELEKALERLKQLEEAIQELKEELAELSAALEEIQEELEELEKELEELE 423
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1225 RHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEP-------------VASPAKKPKVQSGSESVIQEYVDLRTRYSEL 1291
Cdd:COG0419   424 RELEELEEEIKKLEEQINQLESKELMIAELAGAGEKcpvcgqelpeeheKELLELYELELEELEEELSREKEEAELREEI 503
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1292 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLaeahaqAKAQAELEAQELQRRMQEEVARREE 1371
Cdd:COG0419   504 EELEKELRELEEELIELLELEEALKEELEEKLEKLENLLEELEELKEKL------QLQQLKEELRQLEDRLQELKELLEE 577
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1372 AAvdaqqQKRSIQEELQHLRQSSEaeiQAKAQQVEAAERSRmRIEEEIRvvRLQLETTERQRGGAEGELQALRARAEEA- 1450
Cdd:COG0419   578 LR-----LLRTRKEELEELRERLK---ELKKKLKELEERLS-QLEELLQ--SLELSEAENELEEAEEELESELEKLNLQa 646
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1451 --EAQKRQAQEEAERLRRQVQDESQRKRQ---AEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERA 1525
Cdd:COG0419   647 elEELLQAALEELEEKVEELEAEIRRELQrieNEEQLEEKLEELEQLEEELEQLREELEELLKKLGEIEQLIEELESRKA 726

                  ..
gi 254675251 1526 RQ 1527
Cdd:COG0419   727 EL 728
CH_EHBP1 cd21254
calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins; EHBP1 ...
127-226 8.41e-18

calponin homology (CH) domain found in EH domain-binding protein 1 and similar proteins; EHBP1 is a regulator of endocytic recycling and may play a role in actin reorganization by linking clathrin-mediated endocytosis to the actin cytoskeleton. It may act as an effector of small GTPases, including RAB-10 (Rab10), and play a role in vesicle trafficking. EHBP1 is associated with aggressive prostate cancer and insulin-stimulated trafficking and cell migration. Members of this subfamily contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409103  Cd Length: 107  Bit Score: 81.82  E-value: 8.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERdLGVTRLLDP 206
Cdd:cd21254     1 NASQSLLAWCKEVTKGYRGVKITNFTTSWRNGLAFCAILHHFRPDLIDYKSLNPHDIKENNKKAYDGFAS-LGISRLLEP 79
                          90       100
                  ....*....|....*....|.
gi 254675251  207 ED-VDVPQPDEKSIITYVSSL 226
Cdd:cd21254    80 SDmVLLAVPDKLTVMTYLYQI 100
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The ...
1296-2227 9.45e-18

RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 91.57  E-value: 9.45e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1296 SQYIKFISETLRRMEEEERLAEQqrAEERERLAEVEAALEKQRqlaEAHAQAKAQAELEAQELQRRMQEEVARREEAAVD 1375
Cdd:pfam02463  156 LEIEEEAAGSRLKRKKKEALKKL--IEETENLAELIIDLEELK---LQELKLKEQAKKALEYYQLKEKLELEEEYLLYLD 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1376 AQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELqalraraEEAEAQKR 1455
Cdd:pfam02463  231 YLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEE-------EELKSELL 303
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1456 QAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAarEKQRALQALDELRLQAEEAERRLRQAEAERARQVQValeta 1535
Cdd:pfam02463  304 KLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEEL--EKELKELEIKREAEEEEEEELEKLQEKLEQLEEELL----- 376
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1536 qrsAEVELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEaerelerwqLKANEALRLRLQAEE 1615
Cdd:pfam02463  377 ---AKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEEL---------EILEEEEESIELKQG 444
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1616 VAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQ 1695
Cdd:pfam02463  445 KLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRI 524
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1696 LLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL--EAEAGRFRELAEEAARLRA 1773
Cdd:pfam02463  525 ISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLipKLKLPLKSIAVLEIDPILN 604
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1774 LAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQaaLHK 1853
Cdd:pfam02463  605 LAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQ--ELQ 682
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1854 ADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQAELE 1933
Cdd:pfam02463  683 EKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEK 762
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1934 AARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEArrlRERAEQESARQLQLAQEAAQKRLQ 2013
Cdd:pfam02463  763 EEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAE---LLEEEQLLIEQEEKIKEEELEELA 839
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2014 AEEKahaFVVQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQ 2093
Cdd:pfam02463  840 LELK---EEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKE 916
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2094 AQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEE 2173
Cdd:pfam02463  917 NEIEERIKEEAEILLKYEEEPEELLLEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELE 996
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2174 LQRLKAEVTEAARQRSQVEEELF------SVRVQMEELGKLKARIEAENRALILRDKDNT 2227
Cdd:pfam02463  997 KERLEEEKKKLIRAIIEETCQRLkeflelFVSINKGWNKVFFYLELGGSAELRLEDPDDP 1056
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
1321-1910 1.06e-17

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 223496 [Multi-domain]  Cd Length: 908  Bit Score: 91.36  E-value: 1.06e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1321 AEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEIQA 1400
Cdd:COG0419   153 PKERKEILDELFGLEKYEKLSELLKEVIKEAKAKIEELEGQLSELLEDIEDLLEALEEELKELKKLEEIQEEQEEEELEQ 232
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1401 KAQQVEAAERSRMRIEEEIRVVRLQLETTERQrggaegELQALRARAEEAeAQKRQAQEEAERLRRQVQDESQRKRQAEA 1480
Cdd:COG0419   233 EIEALEERLAELEEEKERLEELKARLLEIESL------ELEALKIREEEL-RELERLLEELEEKIERLEELEREIEELEE 305
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1481 ELALRVKA--EAEAAREKQRAL-QALDELRLQAEEAERRLR--QAEAERARQVQVALETAQRSAEVELQSKRASFAEKTA 1555
Cdd:COG0419   306 ELEGLRALleELEELLEKLKSLeERLEKLEEKLEKLESELEelAEEKNELAKLLEERLKELEERLEELEKELEKALERLK 385
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1556 QLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQkslAQADAEKQKEEAE 1635
Cdd:COG0419   386 QLEEAIQELKEELAELSAALEEIQEELEELEKELEELERELEELEEEIKKLEEQINQLESKELM---IAELAGAGEKCPV 462
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1636 REARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKR 1715
Cdd:COG0419   463 CGQELPEEHEKELLELYELELEELEEELSREKEEAELREEIEELEKELRELEEELIELLELEEALKEELEEKLEKLENLL 542
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1716 QELEAELAKVRAEM---EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQ-----RQLAEE 1787
Cdd:COG0419   543 EELEELKEKLQLQQlkeELRQLEDRLQELKELLEELRLLRTRKEELEELRERLKELKKKLKELEERLSQleellQSLELS 622
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1788 DAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERL--RRLAEDEAFQRRRLEEQAALHKADIEERLAQLRK 1865
Cdd:COG0419   623 EAENELEEAEEELESELEKLNLQAELEELLQAALEELEEKVEELeaEIRRELQRIENEEQLEEKLEELEQLEEELEQLRE 702
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 254675251 1866 ASEsELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELE 1910
Cdd:COG0419   703 ELE-ELLKKLGEIEQLIEELESRKAELEELKKELEKLEKALELLE 746
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1302-1933 2.12e-17

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 90.51  E-value: 2.12e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1302 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKqrqLAEAHAQAKAQAELEAQELQRRMqEEVARREEAAVDAQQQKR 1381
Cdd:TIGR02169  239 KEAIERQLASLEEELEKLTEEISELEKRLEEIEQL---LEELNKKIKDLGEEEQLRVKEKI-GELEAEIASLERSIAEKE 314
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1382 SIQEELQHLRQSSEAEIQAKAQQVEAaersrmrIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKR------ 1455
Cdd:TIGR02169  315 RELEDAEERLAKLEAEIDKLLAEIEE-------LEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAetrdel 387
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1456 --------QAQEEAERLRRQVQDESQRKRQAEAELAlRVKAEAEAAREKQRALQA-LDELRLQAEEAERRLRQAEAER-- 1524
Cdd:TIGR02169  388 kdyrekleKLKREINELKRELDRLQEELQRLSEELA-DLNAAIAGIEAKINELEEeKEDKALEIKKQEWKLEQLAADLsk 466
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1525 ARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEE-----------------HVTVAQLREEAerraqqqaeaer 1587
Cdd:TIGR02169  467 YEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVrggraveevlkasiqgvHGTVAQLGSVG------------ 534
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1588 areeaerelERWQLKANEALRLRLQA-----EEVAQQ--KSLAQADAE----------KQKEEAEREARRRG-------- 1642
Cdd:TIGR02169  535 ---------ERYATAIEVAAGNRLNNvvvedDAVAKEaiELLKRRKAGratflplnkmRDERRDLSILSEDGvigfavdl 605
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1643 ----KAEEQAVR---QRELAEQELEKQRQL--------------------------AEGTAQQRLAAEQELIRLRAETEQ 1689
Cdd:TIGR02169  606 vefdPKYEPAFKyvfGDTLVVEDIEAARRLmgkyrmvtlegelfeksgamtggsraPRGGILFSRSEPAELQRLRERLEG 685
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1690 GEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLL----ASKARAEEESRSTSEKSKQRLEAEAgrfrELA 1765
Cdd:TIGR02169  686 LKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEqeeeKLKERLEELEEDLSSLEQEIENVKS----ELK 761
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1766 EEAARLRALaEEAKRQRQLAEEDAARQRAEAE--------RVLTEKLAAISEATRlktEAEIALKEKEAENERLRRLAED 1837
Cdd:TIGR02169  762 ELEARIEEL-EEDLHKLEEALNDLEARLSHSRipeiqaelSKLEEEVSRIEARLR---EIEQKLNRLTLEKEYLEKEIQE 837
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1838 EAFQRRRLEEQAALHKADIEERLAQLRKAsESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIR 1917
Cdd:TIGR02169  838 LQEQRIDLKEQIKSIEKEIENLNGKKEEL-EEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKR 916
                          730
                   ....*....|....*.
gi 254675251  1918 SNAEDTMRSKEQAELE 1933
Cdd:TIGR02169  917 KRLSELKAKLEALEEE 932
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1292-2016 2.76e-17

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 90.03  E-value: 2.76e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1292 TTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAaLEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREE 1371
Cdd:TIGR00618  134 DLLKLDYKTFTRVVLLPQGEFAQFLKAKSKEKKELLMNLFP-LDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPC 212
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1372 AAVDAQQQKRSIQEELQHLR--QSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQrggaEGELQALRARAEE 1449
Cdd:TIGR00618  213 MPDTYHERKQVLEKELKHLReaLQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQ----EAVLEETQERINR 288
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1450 AEAQKRQA--QEEAERLRRQVQDESQRKRQAEAELA-LRVKAEAEAAREKQRALQALDELRLQAEEAERRlRQAEAERAR 1526
Cdd:TIGR00618  289 ARKAAPLAahIKAVTQIEQQAQRIHTELQSKMRSRAkLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIR-DAHEVATSI 367
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1527 QVQVALETAQRSAEVELQSKRASFAEK---TAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1603
Cdd:TIGR00618  368 REISCQQHTLTQHIHTLQQQKTTLTQKlqsLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAI 447
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1604 NEALRLrLQAEEVAQQKSLAQADAEKQ---------KEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLA-------- 1666
Cdd:TIGR00618  448 TCTAQC-EKLEKIHLQESAQSLKEREQqlqtkeqihLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQdidnpgpl 526
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1667 ----EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEE 1742
Cdd:TIGR00618  527 trrmQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEA 606
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1743 SRSTSEKS------------KQRLEAEAGRF-RELAEEAARLRALAEEAKRQRQlaEEDAARQRAEAERVLTEKLAAISE 1809
Cdd:TIGR00618  607 EDMLACEQhallrklqpeqdLQDVRLHLQQCsQELALKLTALHALQLTLTQERV--REHALSIRVLPKELLASRQLALQK 684
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1810 ATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKASES--ELERQK--GLVEDTLRQR 1885
Cdd:TIGR00618  685 MQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSLGSDLAAREDALNQSlkELMHQArtVLKARTEAHF 764
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1886 RQVEEEIMALKVSFEKAAAgKAELElelgrirsnaedtmrskEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEA 1965
Cdd:TIGR00618  765 NNNEEVTAALQTGAELSHL-AAEIQ-----------------FFNRLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETL 826
                          730       740       750       760       770
                   ....*....|....*....|....*....|....*....|....*....|.
gi 254675251  1966 ARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEE 2016
Cdd:TIGR00618  827 VQEEEQFLSRLEEKSATLGEITHQLLKYEECSKQLAQLTQEQAKIIQLSDK 877
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
1376-1938 3.11e-17

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 223496 [Multi-domain]  Cd Length: 908  Bit Score: 89.82  E-value: 3.11e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1376 AQQQKRSIQEELQHLRQSSEAEIQAKaQQVEAAERSRMRIEEEIRVVRLQLE-TTERQRGGAEGELQALRARAEEAEAQK 1454
Cdd:COG0419   152 KPKERKEILDELFGLEKYEKLSELLK-EVIKEAKAKIEELEGQLSELLEDIEdLLEALEEELKELKKLEEIQEEQEEEEL 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1455 RQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQvaLET 1534
Cdd:COG0419   231 EQEIEALEERLAELEEEKERLEELKARLLEIESLELEALKIREEELRELERLLEELEEKIERLEELEREIEELEE--ELE 308
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1535 AQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAE 1614
Cdd:COG0419   309 GLRALLEELEELLEKLKSLEERLEKLEEKLEKLESELEELAEEKNELAKLLEERLKELEERLEELEKELEKALERLKQLE 388
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1615 EVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQR 1694
Cdd:COG0419   389 EAIQELKEELAELSAALEEIQEELEELEKELEELERELEELEEEIKKLEEQINQLESKELMIAELAGAGEKCPVCGQELP 468
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1695 QLLEEELARLQHEATAATQKR-------QELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEE 1767
Cdd:COG0419   469 EEHEKELLELYELELEELEEElsrekeeAELREEIEELEKELRELEEELIELLELEEALKEELEEKLEKLENLLEELEEL 548
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1768 AARLRALAEEAKRQ---RQLAEEDAARQRAEAERVLTEKLAAISEATRL--KTEAEIALKEKEAENERLRRLAEDEAFQR 1842
Cdd:COG0419   549 KEKLQLQQLKEELRqleDRLQELKELLEELRLLRTRKEELEELRERLKElkKKLKELEERLSQLEELLQSLELSEAENEL 628
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1843 RRLEE--QAALHKADIEERLAQLRKASESELERQKGLVEDTLR----------QRRQVEEEIMALKVSFEKAAAGKAELE 1910
Cdd:COG0419   629 EEAEEelESELEKLNLQAELEELLQAALEELEEKVEELEAEIRrelqrieneeQLEEKLEELEQLEEELEQLREELEELL 708
                         570       580
                  ....*....|....*....|....*...
gi 254675251 1911 LELGRIRSNAEDTmrSKEQAELEAARQR 1938
Cdd:COG0419   709 KKLGEIEQLIEEL--ESRKAELEELKKE 734
CH_MICAL2 cd21250
calponin homology (CH) domain found in molecule interacting with CasL protein 2; MICAL-2 is a ...
131-228 5.18e-17

calponin homology (CH) domain found in molecule interacting with CasL protein 2; MICAL-2 is a nuclear [F-actin]-monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). MICAL-2 acts as a key regulator of the serum response factor (SRF) signaling pathway elicited by nerve growth factor and serum. It mediates oxidation and subsequent depolymerization of nuclear actin, leading to the increased MKL1/MRTF-A presence in the nucleus, promoting SRF:MKL1/MRTF-A-dependent gene transcription. MICAL-2 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409099 [Multi-domain]  Cd Length: 110  Bit Score: 79.54  E-value: 5.18e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  131 KLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLD-PEDV 209
Cdd:cd21250     8 KLLTWCQKQTEGYQNVNVTDLTTSWKSGLALCAIIHRFRPELIDFDSLNEDDAVKNNQLAFDVAEREFGIPPVTTgKEMA 87
                          90
                  ....*....|....*....
gi 254675251  210 DVPQPDEKSIITYVSSLYD 228
Cdd:cd21250    88 SAEEPDKLSMVMYLSKFYE 106
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
929-1563 1.28e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 87.80  E-value: 1.28e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   929 HYQQLLQSLEQGEQEESRCQRcisELKDIRLQLEACETR-TVHRLRLpldkdpaRECAQRIAEQQK----AQAEVEGLGK 1003
Cdd:TIGR02168  233 RLEELREELEELQEELKEAEE---ELEELTAELQELEEKlEELRLEV-------SELEEEIEELQKelyaLANEISRLEQ 302
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1004 GVARLSAEAEKVLA-LPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKTHEEQLKE--- 1079
Cdd:TIGR02168  303 QKQILRERLANLERqLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEqle 382
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1080 --AQAVPATLQELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQ-QRHGERDVEVERWRERVTQLLERWQAV 1156
Cdd:TIGR02168  383 tlRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAElKELQAELEELEEELEELQEELERLEEA 462
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1157 LAQTDVRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAvPIANCQAAREQLRQEKALLEEIERHGEKVEEC--- 1233
Cdd:TIGR02168  463 LEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSE-GVKALLKNQSGLSGILGVLSELISVDEGYEAAiea 541
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1234 -------------QKFAKQYINAIKDYELQLITYKA--QLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSE----LTTL 1294
Cdd:TIGR02168  542 alggrlqavvvenLNAAKKAIAFLKQNELGRVTFLPldSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKlrkaLSYL 621
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1295 TSQYikFISETL-------RRMEEEERL--------------------AEQQRAEERERLAEVEAALEK-QRQLAEAHAQ 1346
Cdd:TIGR02168  622 LGGV--LVVDDLdnalelaKKLRPGYRIvtldgdlvrpggvitggsakTNSSILERRREIEELEEKIEElEEKIAELEKA 699
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1347 ----AKAQAELEAQELQRRMQEEVARREEAAVDAQQQK-RSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRV 1421
Cdd:TIGR02168  700 laelRKELEELEEELEQLRKELEELSRQISALRKDLARlEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAE 779
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1422 VRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQ 1501
Cdd:TIGR02168  780 AEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELSEDIESLAA 859
                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675251  1502 ALDELRLQAEEAERRLRQAEAERArQVQVALETAqRSAEVELQSKRASFAEKTAQLERTLQE 1563
Cdd:TIGR02168  860 EIEELEELIEELESELEALLNERA-SLEEALALL-RSELEELSEELRELESKRSELRRELEE 919
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
919-1565 2.38e-16

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 87.08  E-value: 2.38e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  919 AEREYGSCSRHYQQLLQSLEQGEQEESRCQrciSELKDIRLQLEACETRTVHR--------LRLPLDKDPARECAQRIAE 990
Cdd:COG1196   244 LEEELSRLEEELEELQEELEEAEKEIEELK---SELEELREELEELQEELLELkeeieeleGEISLLRERLEELENELEE 320
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  991 QQKAQAEVEglgkgvARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKT-----ISLVIRSTQG 1065
Cdd:COG1196   321 LEERLEELK------EKIEALKEELEERETLLEELEQLLAELEEAKEELEEKLSALLEELEELFEalreeLAELEAELAE 394
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1066 AEEVLKTHEEQLKEAQAVPATLQE-LEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRE 1144
Cdd:COG1196   395 IRNELEELKREIESLEERLERLSErLEDLKEELKELEAELEELQTELEELNEELEELEEQLEELRDRLKELERELAELQE 474
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1145 RVTQLLERWQAVLAQTDV--RQRELEQLGRQLRYYRESADP----LSAWLQDAKRRQEQ---------IQAVPIANCQAA 1209
Cdd:COG1196   475 ELQRLEKELSSLEARLDRleAEQRASQGVRAVLEALESGLPgvygPVAELIKVKEKYETaleaalgnrLQAVVVENEEVA 554
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1210 R---EQLRQEKA------LLEEIE-RHGEKVEECQKFAKQYINAIK-DYELQLI-------TYKAQLEPVASP-AKKPKV 1270
Cdd:COG1196   555 KkaiEFLKENKAgratflPLDRIKpLRSLKSDAAPGFLGLASDLIDfDPKYEPAvrfvlgdTLVVDDLEQARRlARKLRI 634
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1271 QSGSESVIQEYVDLR--------------TRYSELTTLTSQyIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK 1336
Cdd:COG1196   635 KYRIVTLDGDLVEPSgsitggsrnkrsslAQKRELKELEEE-LAELEAQLEKLEEELKSLKNELRSLEDLLEELRRQLEE 713
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1337 QRQLAEAHAQAKAQAELEAQELQRRMQ---EEVARREEAAVDAQQQKRSIQEELQHLrQSSEAEIQAkaqQVEAAERSRM 1413
Cdd:COG1196   714 LERQLEELKRELAALEEELEQLQSRLEeleEELEELEEELEELQERLEELEEELESL-EEALAKLKE---EIEELEEKRQ 789
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1414 RIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAA 1493
Cdd:COG1196   790 ALQEELEELEEELEEAERRLDALERELESLEQRRERLEQEIEELEEEIEELEEKLDELEEELEELEKELEELKEELEELE 869
                         650       660       670       680       690       700       710
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675251 1494 REKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALEtaQRSAEVELQSKRASFAEKTAQLERTLQEEH 1565
Cdd:COG1196   870 AEKEELEDELKELEEEKEELEEELRELESELAELKEEIEK--LRERLEELEAKLERLEVELPELEEELEEEY 939
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The ...
1786-2572 3.55e-16

RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 86.56  E-value: 3.55e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1786 EEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAlhkadIEERLAQLRK 1865
Cdd:pfam02463  143 KIEIIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAK-----KALEYYQLKE 217
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1866 ASESELERQKGLVEDTLRQRRQVEEEimalkvsfEKAAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQRQLAAEEE 1945
Cdd:pfam02463  218 KLELEEEYLLYLDYLKLNEERIDLLQ--------ELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELK 289
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1946 QRRREAEERVQRSLAAEeeaaRQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKahafvVQQ 2025
Cdd:pfam02463  290 LLAKEEEELKSELLKLE----RRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEE-----EEE 360
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2026 REEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERlKQSAEEQAQAQAQAQAAAEKLRK 2105
Cdd:pfam02463  361 LEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQ-LEDLLKEEKKEELEILEEEEESI 439
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2106 EAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELqrlkaEVTEAA 2185
Cdd:pfam02463  440 ELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSG-----LKVLLA 514
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2186 RQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAE------EAARLSVAAQEAARLR 2259
Cdd:pfam02463  515 LIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQKLVRALTElplgarKLRLLIPKLKLPLKSI 594
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2260 QLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQR 2339
Cdd:pfam02463  595 AVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKE 674
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2340 QLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAE 2419
Cdd:pfam02463  675 LLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEK 754
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2420 LEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKA-KQLREE 2498
Cdd:pfam02463  755 SRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEeKIKEEE 834
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251  2499 QQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEHRA 2572
Cdd:pfam02463  835 LEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQK 908
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1790-2570 4.51e-16

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 86.31  E-value: 4.51e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1790 ARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKaDIEERLAQLRKASES 1869
Cdd:COG1196   150 INAKPEERRKLIEEAAGVSKYKERKEEAERKLERTEENLERLEDLLEELEKQLEKLERQAEKAE-RYQELKAELRELELA 228
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1870 ELERQkglVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQRQLAAEEEQRRR 1949
Cdd:COG1196   229 LLLAK---LKELRKELEELEEELSRLEEELEELQEELEEAEKEIEELKSELEELREELEELQEELLELKEEIEELEGEIS 305
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1950 EAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKR--LQAEEKAHAFVVQQRE 2027
Cdd:COG1196   306 LLRERLEELENELEELEERLEELKEKIEALKEELEERETLLEELEQLLAELEEAKEELEEKLsaLLEELEELFEALREEL 385
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2028 EELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEA 2107
Cdd:COG1196   386 AELEAELAEIRNELEELKREIESLEERLERLSERLEDLKEELKELEAELEELQTELEELNEELEELEEQLEELRDRLKEL 465
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2108 EQEAARRAQAEQAALKQKQaadaEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQ 2187
Cdd:COG1196   466 ERELAELQEELQRLEKELS----SLEARLDRLEAEQRASQGVRAVLEALESGLPGVYGPVAELIKVKEKYETALEAALGN 541
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2188 RSQ---VEEELFSVRVqMEELGKLKA---------RIEAENRALILRDKDNTQRFLE-EEAEKMKQVA------------ 2242
Cdd:COG1196   542 RLQavvVENEEVAKKA-IEFLKENKAgratflpldRIKPLRSLKSDAAPGFLGLASDlIDFDPKYEPAvrfvlgdtlvvd 620
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2243 --EEAARLSVAAQEAARL--------------------------RQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2294
Cdd:COG1196   621 dlEQARRLARKLRIKYRIvtldgdlvepsgsitggsrnkrsslaQKRELKELEEELAELEAQLEKLEEELKSLKNELRSL 700
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2295 ELLQQQKELAQEQARR--------------LQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRA 2360
Cdd:COG1196   701 EDLLEELRRQLEELERqleelkrelaaleeELEQLQSRLEELEEELEELEEELEELQERLEELEEELESLEEALAKLKEE 780
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2361 QARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEE 2440
Cdd:COG1196   781 IEELEEKRQALQEELEELEEELEEAERRLDALERELESLEQRRERLEQEIEELEEEIEELEEKLDELEEELEELEKELEE 860
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2441 MQTvQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLfQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEA 2520
Cdd:COG1196   861 LKE-ELEELEAEKEELEDELKELEEEKEELEEELRELESELAEL-KEEIEKLRERLEELEAKLERLEVELPELEEELEEE 938
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|
gi 254675251 2521 rrRQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEH 2570
Cdd:COG1196   939 --YEDTLETELEREIERLEEEIEALGPVNLRAIEEYEEVEERYEELKSQR 986
CH_SMTNB cd21259
calponin homology (CH) domain found in smoothelin-B and similar proteins; Smoothelins are ...
129-227 6.67e-16

calponin homology (CH) domain found in smoothelin-B and similar proteins; Smoothelins are actin-binding cytoskeletal proteins that are abundantly expressed in healthy visceral (smoothelin-A) and vascular (smoothelin-B) smooth muscle. The human SMTN gene encodes smoothelin-A and smoothelin-B. This model corresponds to the single CH domain of smoothelin-B. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409108  Cd Length: 112  Bit Score: 76.57  E-value: 6.67e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  129 KEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED 208
Cdd:cd21259     3 KQMLLDWCRAKTRGYENVDIQNFSSSWSDGMAFCALVHNFFPEAFDYSQLSPQNRRHNFEVAFSSAEKHADCPQLLDVED 82
                          90       100
                  ....*....|....*....|
gi 254675251  209 -VDVPQPDEKSIITYVSSLY 227
Cdd:cd21259    83 mVRMREPDWKCVYTYIQEFY 102
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1754-2570 7.31e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.49  E-value: 7.31e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1754 LEAEAGRFRELAEEAA---RLRALAEEAKRQRQLAEEDAAR------------QRAEAERVLTEKLAAISEATRlKTEAE 1818
Cdd:TIGR02168  150 IEAKPEERRAIFEEAAgisKYKERRKETERKLERTRENLDRledilnelerqlKSLERQAEKAERYKELKAELR-ELELA 228
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1819 IALKEKEAENERLRRLAED-EAFQRRRLEEQAALHKAdiEERLAQLRKAS---ESELERQKGLVEDTLRQRRQVEEEIMA 1894
Cdd:TIGR02168  229 LLVLRLEELREELEELQEElKEAEEELEELTAELQEL--EEKLEELRLEVselEEEIEELQKELYALANEISRLEQQKQI 306
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1895 LKVSFEKAAAGKAELELELgrirsnaEDTMRSKEQAELEAARQRQlaaeeeqrRREAEERVQRSLAAEEEAARqrkvalE 1974
Cdd:TIGR02168  307 LRERLANLERQLEELEAQL-------EELESKLDELAEELAELEE--------KLEELKEELESLEAELEELE------A 365
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1975 EVERLKAKVEEARRLRERAEQESArQLQLAQEAAQKRLQ-AEEKAHAFVVQQREEELQQTLQQEQNMLDRLRSEAEAARR 2053
Cdd:TIGR02168  366 ELEELESRLEELEEQLETLRSKVA-QLELQIASLNNEIErLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEE 444
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2054 AAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADaeme 2133
Cdd:TIGR02168  445 LEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSG---- 520
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2134 khkkfAEQTLRQKAQVEQElttLRLQLEETdhqksiLDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIE 2213
Cdd:TIGR02168  521 -----ILGVLSELISVDEG---YEAAIEAA------LGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEI 586
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2214 AENRALILRDKDNTQRF---LEEEAEKMKQVAEEA-ARLSVAAQEAARLRQLAEED------------------LAQQRA 2271
Cdd:TIGR02168  587 QGNDREILKNIEGFLGVakdLVKFDPKLRKALSYLlGGVLVVDDLDNALELAKKLRpgyrivtldgdlvrpggvITGGSA 666
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2272 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLK 2351
Cdd:TIGR02168  667 KTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLE 746
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2352 LRMAEMSRAQARAEEdaqrfrkQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEA 2431
Cdd:TIGR02168  747 ERIAQLSKELTELEA-------EIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEA 819
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2432 KLLQLKSEEMQTvQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLfQDEVAKAKQLREEQQRQQQQMEQEKQ 2511
Cdd:TIGR02168  820 ANLRERLESLER-RIAATERRLEDLEEQIEELSEDIESLAAEIEELEELIEEL-ESELEALLNERASLEEALALLRSELE 897
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251  2512 ELMASMEEARRRQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEH 2570
Cdd:TIGR02168  898 ELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEA 956
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1197-1902 7.44e-16

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 85.41  E-value: 7.44e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1197 QIQAVPIANCQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAKKPKVQSGSES 1276
Cdd:TIGR00618  222 QVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKA 301
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1277 VIQEYVDLRTRYSELttltsqyikfisetlrrmEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQ 1356
Cdd:TIGR00618  302 VTQIEQQAQRIHTEL------------------QSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEV 363
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1357 ELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVR----LQLETTERQ 1432
Cdd:TIGR00618  364 ATSIREISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQLAHAKkqqeLQQRYAELC 443
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1433 RGGAEGELQALRARAEEAE--AQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQA 1510
Cdd:TIGR00618  444 AAAITCTAQCEKLEKIHLQesAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARQDIDNP 523
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1511 EEAERRLRQAEAERARqvqvaLETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVAQlreeaerraqqqaeaerare 1590
Cdd:TIGR00618  524 GPLTRRMQRGEQTYAQ-----LETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQC-------------------- 578
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1591 eaerelerWQLKANEALRLRLQAEEVaqQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA 1670
Cdd:TIGR00618  579 --------DNRSKEDIPNLQNITVRL--QDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTAL 648
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1671 QQ---RLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLAS-KARAEEESRST 1746
Cdd:TIGR00618  649 HAlqlTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYdREFNEIENASS 728
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1747 SEKSK--QRLEAEA---GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLkteaeiaL 1821
Cdd:TIGR00618  729 SLGSDlaAREDALNqslKELMHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFNRLREEDTHL-------L 801
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1822 KEKEAENERLRRLAEDEafqrrrLEEQAALHKADIEERLAQLRKASES--ELERQKGLVEDTLRQRRQVEEEIMALKVSF 1899
Cdd:TIGR00618  802 KTLEAEIGQEIPSDEDI------LNLQCETLVQEEEQFLSRLEEKSATlgEITHQLLKYEECSKQLAQLTQEQAKIIQLS 875

                   ...
gi 254675251  1900 EKA 1902
Cdd:TIGR00618  876 DKL 878
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1378-2321 1.07e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 84.73  E-value: 1.07e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1378 QQKRSIQEELQHLRQSsEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEgELQALRARAEEAEA----- 1452
Cdd:TIGR02169  153 VERRKIIDEIAGVAEF-DRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAE-RYQALLKEKREYEGyellk 230
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1453 QKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAR------EKQRALQALDELRLQAEEAE-----RRLRQAE 1521
Cdd:TIGR02169  231 EKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQlleelnKKIKDLGEEEQLRVKEKIGEleaeiASLERSI 310
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1522 AERARQVQVALETaqrsaEVELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQaeaerareeaerelerwql 1601
Cdd:TIGR02169  311 AEKERELEDAEER-----LAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEEL------------------- 366
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1602 kanEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQR-ELAEQELEKQRQLAEGTAQQRLAAEQEL 1680
Cdd:TIGR02169  367 ---EDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEElQRLSEELADLNAAIAGIEAKINELEEEK 443
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1681 IRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEE---SRSTSEKSKQRLEAE 1757
Cdd:TIGR02169  444 EDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERvrgGRAVEEVLKASIQGV 523
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1758 AGRFRELAEeaarlralaeeAKRQRQLAEEDAARQRAEAERVLTEKLAAiseatrlktEAEIALKEKEAENER---LRRL 1834
Cdd:TIGR02169  524 HGTVAQLGS-----------VGERYATAIEVAAGNRLNNVVVEDDAVAK---------EAIELLKRRKAGRATflpLNKM 583
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1835 AEDEAFQRRRLEEQAALHKADIEERLAQLRKASESELeRQKGLVEDTLRQRRQVEEEIMalkVS-----FEKAAAgkael 1909
Cdd:TIGR02169  584 RDERRDLSILSEDGVIGFAVDLVEFDPKYEPAFKYVF-GDTLVVEDIEAARRLMGKYRM---VTlegelFEKSGA----- 654
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1910 eLELGRIRSNAEDTMRSKEQAELEAARQRqlaaeeeqrrreaeervqrslaaEEEAARQRKVALEEVERLKAKVEEARRL 1989
Cdd:TIGR02169  655 -MTGGSRAPRGGILFSRSEPAELQRLRER-----------------------LEGLKRELSSLQSELRRIENRLDELSQE 710
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1990 RERAEQE----SARQLQLAQEAAQKRLQAEEkahafvVQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQA 2065
Cdd:TIGR02169  711 LSDASRKigeiEKEIEQLEQEEEKLKERLEE------LEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDL 784
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2066 EREAAQSRKQVEEAERLKQsaeeqaqaqaqaqaaaEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQ 2145
Cdd:TIGR02169  785 EARLSHSRIPEIQAELSKL----------------EEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQ 848
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2146 KAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELfsvRVQMEELGKLKARIEAENraliLRDKD 2225
Cdd:TIGR02169  849 IKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQL---RELERKIEELEAQIEKKR----KRLSE 921
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2226 NTQRfLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALaEKMLKEKMQAVQEATRLKAEAELLQQQKELAQ 2305
Cdd:TIGR02169  922 LKAK-LEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEEEI-RALEPVNMLAIQEYEEVLKRLDELKEKRAKLE 999
                          970
                   ....*....|....*.
gi 254675251  2306 EQARRLQEDKEQMAQQ 2321
Cdd:TIGR02169 1000 EERKAILERIEEYEKK 1015
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3428-3466 1.42e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 72.76  E-value: 1.42e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3428 LLEAQVATGGIIDPVHSHRLPVDVAYQRGYFDEEMNRVL 3466
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
CH_CYTS cd21199
calponin homology (CH) domain found in the cytospin family; The cytospin family includes ...
132-227 1.80e-15

calponin homology (CH) domain found in the cytospin family; The cytospin family includes cytospin-A and cytospin-B. Cytospin-A, also called renal carcinoma antigen NY-REN-22, sperm antigen with calponin homology and coiled-coil domains 1-like, or SPECC1-like (SPECC1L) protein, is involved in cytokinesis and spindle organization. It may play a role in actin cytoskeleton organization and microtubule stabilization and hence, is required for proper cell adhesion and migration. Cytospin-B, also called nuclear structure protein 5 (NSP5), sperm antigen HCMOGT-1, or sperm antigen with calponin homology and coiled-coil domains 1 (SPECC1), is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with translocation t(5;17)(q33;p11.2). Members of this family contain a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409048  Cd Length: 112  Bit Score: 75.09  E-value: 1.80e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  132 LLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAErDLGVTRLLDPED-VD 210
Cdd:cd21199    13 LLKWCQEKTQGYKGIDITNFSSSWNDGLAFCALLHSYLPDKIPYSELNPQDKRRNFTLAFKAAE-SVGIPTTLTIDEmVS 91
                          90
                  ....*....|....*..
gi 254675251  211 VPQPDEKSIITYVSSLY 227
Cdd:cd21199    92 MERPDWQSVMSYVTAIY 108
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1600-2460 1.84e-15

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 83.96  E-value: 1.84e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1600 QLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLA---- 1675
Cdd:TIGR02169  231 EKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLersi 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1676 --AEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1753
Cdd:TIGR02169  311 aeKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDY 390
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1754 LEAEAGRFRELAEEAARLRALAEEAKRqrqlAEEDAARQRAEAERVLTEKLAAISEatrlKTEAEIALKEKEAENERLRR 1833
Cdd:TIGR02169  391 REKLEKLKREINELKRELDRLQEELQR----LSEELADLNAAIAGIEAKINELEEE----KEDKALEIKKQEWKLEQLAA 462
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1834 LAEDEAFQRRRLEEQAalhkADIEERLAQLRKaSESELERQKGLVEDTLRQRRQVEEEImalkvsfEKAAAGKAELELEL 1913
Cdd:TIGR02169  463 DLSKYEQELYDLKEEY----DRVEKELSKLQR-ELAEAEAQARASEERVRGGRAVEEVL-------KASIQGVHGTVAQL 530
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1914 GRIrsnaedtmRSKEQAELEAARQRQLaaeeeqrrreaeervqRSLAAEEEAarqrkVALEEVERLKA------------ 1981
Cdd:TIGR02169  531 GSV--------GERYATAIEVAAGNRL----------------NNVVVEDDA-----VAKEAIELLKRrkagratflpln 581
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1982 KVEEARRLRERAEQESARQLQLAQEAAQKRLqaeEKAHAFVVQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEA 2061
Cdd:TIGR02169  582 KMRDERRDLSILSEDGVIGFAVDLVEFDPKY---EPAFKYVFGDTLVVEDIEAARRLMGKYRMVTLEGELFEKSGAMTGG 658
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2062 REQAEREAAQSRKQVEEAERL---KQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKF 2138
Cdd:TIGR02169  659 SRAPRGGILFSRSEPAELQRLrerLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKER 738
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2139 AEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVteAARQRSQVEEELFSVRVQMEELGKLKARIEAENRA 2218
Cdd:TIGR02169  739 LEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEAL--NDLEARLSHSRIPEIQAELSKLEEEVSRIEARLRE 816
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2219 L--ILRDKDNTQRFLEEEAEKMKQVAEEAarlsvAAQEAARLRQLaEEDLAQQRALAEKmLKEKMQAVQEatrLKAEAEL 2296
Cdd:TIGR02169  817 IeqKLNRLTLEKEYLEKEIQELQEQRIDL-----KEQIKSIEKEI-ENLNGKKEELEEE-LEELEAALRD---LESRLGD 886
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2297 LQQQKELAQEQARRLQEDKEQMAQQlVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAE 2376
Cdd:TIGR02169  887 LKKERDELEAQLRELERKIEELEAQ-IEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEIPEEELSLEDVQAELQRVEE 965
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2377 EIgeklhrtelatqEKVTLVQTLEIQrqqsdhDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQAL 2456
Cdd:TIGR02169  966 EI------------RALEPVNMLAIQ------EYEEVLKRLDELKEKRAKLEEERKAILERIEEYEKKKREVFMEAFEAI 1027

                   ....
gi 254675251  2457 QKSF 2460
Cdd:TIGR02169 1028 NENF 1031
CH_SMTNL2 cd21261
calponin homology (CH) domain found in smoothelin-like protein 2; Smoothelin-like protein 2 ...
129-228 2.02e-15

calponin homology (CH) domain found in smoothelin-like protein 2; Smoothelin-like protein 2 (SMTNL2) is highly expressed in skeletal muscle and could be associated with differentiating myocytes. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409110  Cd Length: 107  Bit Score: 75.00  E-value: 2.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  129 KEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED 208
Cdd:cd21261     3 KQILLEWCRSKTIGYKNIDLQNFSSSWSDGMAFCALVHSFFPEAFDYDSLSPSNRKHNFELAFSMAEKLANCDRLIEVED 82
                          90       100
                  ....*....|....*....|..
gi 254675251  209 VDV--PQPDEKSIITYVSSLYD 228
Cdd:cd21261    83 MMVmgRKPDPMCVFTYVQSLYN 104
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4006-4044 2.58e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 72.37  E-value: 2.58e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  4006 LLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEMNEIL 4044
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
CH_SMTNA cd21258
calponin homology (CH) domain found in smoothelin-A and similar proteins; Smoothelins are ...
129-232 3.04e-15

calponin homology (CH) domain found in smoothelin-A and similar proteins; Smoothelins are actin-binding cytoskeletal proteins that are abundantly expressed in healthy visceral (smoothelin-A) and vascular (smoothelin-B) smooth muscle. This model corresponds to the single CH domain of smoothelin-A. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409107  Cd Length: 111  Bit Score: 74.70  E-value: 3.04e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  129 KEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED 208
Cdd:cd21258     3 KQMLLDWCRAKTRGYEHVDIQNFSSSWSDGMAFCALVHNFFPDAFDYSQLSPQNRRQNFEVAFSAAEMLADCVPLVEVED 82
                          90       100
                  ....*....|....*....|....*.
gi 254675251  209 VDV--PQPDEKSIITYVSSLYDAMPR 232
Cdd:cd21258    83 MMImgKKPDSKCVFTYVQSLYNHLRR 108
CH_CTX_rpt1 cd21225
first calponin homology (CH) domain found in cortexillin; Cortexillins are actin-bundling ...
9-108 3.62e-15

first calponin homology (CH) domain found in cortexillin; Cortexillins are actin-bundling proteins that play a critical role in regulating cell morphology and actin cytoskeleton reorganization. They play a major role in cytokinesis and contain two copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409074  Cd Length: 111  Bit Score: 74.49  E-value: 3.62e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    9 DRVQKKTFTKWVNKHLIKAQ-RHISDLYEDLRDGHNLISLLEVLSGDSLPRE---KGRMRFHKLQNVQIALDYLRHR-QV 83
Cdd:cd21225     2 EKVQIKAFTAWVNSVLEKRGiPKISDLATDLSDGVRLIFFLELVSGKKFPKKfdlEPKNRIQMIQNLHLAMLFIEEDlKI 81
                          90       100
                  ....*....|....*....|....*
gi 254675251   84 KLVNIRNDDIADGNPKLTLGLIWTI 108
Cdd:cd21225    82 RVQGIGAEDFVDNNKKLILGLLWTL 106
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
2769-2807 5.21e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 71.22  E-value: 5.21e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  2769 LLEAQIATGGIIDPVHSHRVPVDVAYKRGYFDEEMNRIL 2807
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3687-3725 7.55e-15

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 70.83  E-value: 7.55e-15
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3687 LLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPELHDRL 3725
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
CH_PLS_FIM_rpt3 cd21219
third calponin homology (CH) domain found in the plastin/fimbrin family; This family includes ...
6-111 1.20e-14

third calponin homology (CH) domain found in the plastin/fimbrin family; This family includes plastin and fimbrin. Plastin has three isoforms, plastin-1, -2, and -3. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, or LC64P, or lymphocyte cytosolic protein 1 (LCP-1), is an actin-binding protein that plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is an actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Fimbrin has been found in plants and fungi. Arabidopsis thaliana fimbrin (AtFIM) includes fimbrin-1, -2, -3, -4, and -5, which cross-link actin filaments (F-actin) in a calcium independent manner. They stabilize and prevent F-actin depolymerization mediated by profilin. They act as key regulators of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus. AtFIM5 is an actin bundling factor that is required for pollen germination and pollen tube growth. Fungal fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the third CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409068  Cd Length: 113  Bit Score: 72.70  E-value: 1.20e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    6 DERDrvqKKTFTKWVNKHLIKAQrhISDLYEDLRDGhnlISLLEVLsgDSL-P---------REKGRMRFHKLQNVQIAL 75
Cdd:cd21219     2 GSRE---ERAFRMWLNSLGLDPL--INNLYEDLRDG---LVLLQVL--DKIqPgcvnwkkvnKPKPLNKFKKVENCNYAV 71
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 254675251   76 DYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILH 111
Cdd:cd21219    72 DLAKKLGFSLVGIGGKDIADGNRKLTLALVWQLMRY 107
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1030-1895 1.63e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 80.88  E-value: 1.63e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1030 SELELTLGKLEQVRslsaiylEKLKTISLVIRSTQGAEEVLKTHEEQLKEAQAVPATLQELEATK--ASLKKLRAQAEAQ 1107
Cdd:TIGR02169  170 RKKEKALEELEEVE-------ENIERLDLIIDEKRQQLERLRREREKAERYQALLKEKREYEGYEllKEKEALERQKEAI 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1108 QPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLaqtdvrQRELEQLGRQLRYYRESADPLSAW 1187
Cdd:TIGR02169  243 ERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRV------KEKIGELEAEIASLERSIAEKERE 316
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1188 LQDAKRRQEQIQAvpiancqaareqlrQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAKK 1267
Cdd:TIGR02169  317 LEDAEERLAKLEA--------------EIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAE 382
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1268 PKvqsgsesviQEYVDLRTRYSELTtltsQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAhaqa 1347
Cdd:TIGR02169  383 TR---------DELKDYREKLEKLK----REINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKED---- 445
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1348 kAQAELEAQElqRRMQEEVARREeaavDAQQQKRSIQEELQHLrqssEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLE 1427
Cdd:TIGR02169  446 -KALEIKKQE--WKLEQLAADLS----KYEQELYDLKEEYDRV----EKELSKLQRELAEAEAQARASEERVRGGRAVEE 514
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1428 TTERQRGGAEGELQALraraEEAEAQKRQAQEEAERLRRQ---VQDESQRKRQAEaeLALRVKA------EAEAAREKQR 1498
Cdd:TIGR02169  515 VLKASIQGVHGTVAQL----GSVGERYATAIEVAAGNRLNnvvVEDDAVAKEAIE--LLKRRKAgratflPLNKMRDERR 588
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1499 ALQALDE-----LRLQAEEAERRLRQAEAERARQVQV--ALETAQR--------SAEVELQSKRA-----SFAEKTAQLE 1558
Cdd:TIGR02169  589 DLSILSEdgvigFAVDLVEFDPKYEPAFKYVFGDTLVveDIEAARRlmgkyrmvTLEGELFEKSGamtggSRAPRGGILF 668
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1559 RTLQEEhvtvaqlreeaerraqqqaeaerareeaerelerwqlkanEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREA 1638
Cdd:TIGR02169  669 SRSEPA----------------------------------------ELQRLRERLEGLKRELSSLQSELRRIENRLDELS 708
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1639 RRRGKAEEQAV---RQRELAEQELEKQRQLAEG-------TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLqhEA 1708
Cdd:TIGR02169  709 QELSDASRKIGeieKEIEQLEQEEEKLKERLEEleedlssLEQEIENVKSELKELEARIEELEEDLHKLEEALNDL--EA 786
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1709 TAATQKRQELEAELAKVRAEmevllaskaRAEEESRSTS-EKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE 1787
Cdd:TIGR02169  787 RLSHSRIPEIQAELSKLEEE---------VSRIEARLREiEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIE 857
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1788 DAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIE---ERLAQLR 1864
Cdd:TIGR02169  858 NLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEaleEELSEIE 937
                          890       900       910
                   ....*....|....*....|....*....|...
gi 254675251  1865 KASESELERQKGL--VEDTLRQRRQVEEEIMAL 1895
Cdd:TIGR02169  938 DPKGEDEEIPEEElsLEDVQAELQRVEEEIRAL 970
PTZ00121 PTZ00121
MAEBL; Provisional
1066-1564 1.78e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 80.96  E-value: 1.78e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1066 AEEVLKTHEEQLKEAQAVPATLQELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDvEVERWRER 1145
Cdd:PTZ00121 1338 AEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKKAD-ELKKAAAA 1416
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1146 VTQLLErwqavLAQTDVRQRELEQLGRQLRYYREsADPLSAWLQDAKRRQEQIQAVPIANCQAAREQLRQEKALLEEIER 1225
Cdd:PTZ00121 1417 KKKADE-----AKKKAEEKKKADEAKKKAEEAKK-ADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKK 1490
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1226 hgeKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAKKPKVQSGSESViqeyvdlrtRYSELTTLTSQYIKfiSET 1305
Cdd:PTZ00121 1491 ---KAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEA---------KKAEEKKKADELKK--AEE 1556
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1306 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQlaeahaQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQE 1385
Cdd:PTZ00121 1557 LKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAE------EARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEE 1630
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1386 ELQHLRQ--SSEAEIQAKAQQVEAAERsrmriEEEIRVVRLQLETTERQRGGAEgelqalrarAEEAEAQKRQAQEEAER 1463
Cdd:PTZ00121 1631 EKKKVEQlkKKEAEEKKKAEELKKAEE-----ENKIKAAEEAKKAEEDKKKAEE---------AKKAEEDEKKAAEALKK 1696
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1464 LRRQVQDESQRKRQAEAELAlrvKAEAEAAREKQRALQAlDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVEL 1543
Cdd:PTZ00121 1697 EAEEAKKAEELKKKEAEEKK---KAEELKKAEEENKIKA-EEAKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEE 1772
                         490       500
                  ....*....|....*....|.
gi 254675251 1544 QSKrasfaEKTAQLERTLQEE 1564
Cdd:PTZ00121 1773 IRK-----EKEAVIEEELDEE 1788
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The ...
1691-2561 1.79e-14

RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 80.79  E-value: 1.79e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1691 EQQRQLLEEELARLQHEAtaatQKRQELEaELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAAR 1770
Cdd:pfam02463  152 PERRLEIEEEAAGSRLKR----KKKEALK-KLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYL 226
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1771 L--RALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKtEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1848
Cdd:pfam02463  227 LylDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLK-ENKEEEKEKKLQEEELKLLAKEEEELKSELLKL 305
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1849 AALHKADIEERlaqlrKASESE---LERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDT-- 1923
Cdd:pfam02463  306 ERRKVDDEEKL-----KESEKEkkkAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKkk 380
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1924 ----MRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESAR 1999
Cdd:pfam02463  381 leseRLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKL 460
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2000 QLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEA 2079
Cdd:pfam02463  461 LKDELELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVEN 540
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2080 ERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLR---QKAQVEQELTTL 2156
Cdd:pfam02463  541 YKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLaqlDKATLEADEDDK 620
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2157 RLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAE 2236
Cdd:pfam02463  621 RAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLE 700
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2237 KMKQVAEEAARLSVAAQEA----ARLRQLAEEDLAQQRALAEKMLKEKMQaVQEATRLKAEAELLQQQKELAQEQARRLQ 2312
Cdd:pfam02463  701 IKKKEQREKEELKKLKLEAeellADRVQEAQDKINEELKLLKQKIDEEEE-EEEKSRLKKEEKEEEKSELSLKEKELAEE 779
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2313 EDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKlhrtELATQEK 2392
Cdd:pfam02463  780 REKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKL----EKLAEEE 855
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2393 VTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRER 2472
Cdd:pfam02463  856 LERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEE 935
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2473 FIEQEK-AKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREaeegVRRKQEELQHLEQQRQQQEKL 2551
Cdd:pfam02463  936 EPEELLlEEADEKEKEENNKEEEEERNKRLLLAKEELGKVNLMAIEEFEEKEERY----NKDELEKERLEEEKKKLIRAI 1011
                          890
                   ....*....|
gi 254675251  2552 LAEENQRLRE 2561
Cdd:pfam02463 1012 IEETCQRLKE 1021
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
931-1840 1.98e-14

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 80.88  E-value: 1.98e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   931 QQLLQSLEQGEQEESRCQRCISELKDirlQLEACETRTVHRLRLPLDKDPARECAQ--RIAEQQKAQAEVEGLGKGVARL 1008
Cdd:TIGR02169  173 EKALEELEEVEENIERLDLIIDEKRQ---QLERLRREREKAERYQALLKEKREYEGyeLLKEKEALERQKEAIERQLASL 249
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1009 SAEAEKVLALpepspaaptlRSELELTLGKLEQVRSLSAIYLEKL-----KTISLVIRSTQG----AEEVLKTHEEQLKE 1079
Cdd:TIGR02169  250 EEELEKLTEE----------ISELEKRLEEIEQLLEELNKKIKDLgeeeqLRVKEKIGELEAeiasLERSIAEKERELED 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1080 AQAVPATLQ-ELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQllerwqavla 1158
Cdd:TIGR02169  320 AEERLAKLEaEIDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKD---------- 389
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1159 qtdvRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAvpiancqaareqlrqekalleEIERHGEKVEECQKFAK 1238
Cdd:TIGR02169  390 ----YREKLEKLKREINELKRELDRLQEELQRLSEELADLNA---------------------AIAGIEAKINELEEEKE 444
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1239 QYINAIKDYELQLITYKAQLepvaspakkpkvqsgsESVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQ 1318
Cdd:TIGR02169  445 DKALEIKKQEWKLEQLAADL----------------SKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQARASEERVRG 508
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1319 QRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQElqrRMQEEVARREEAAVDAQQQKRS-------------IQE 1385
Cdd:TIGR02169  509 GRAVEEVLKASIQGVHGTVAQLGSVGERYATAIEVAAGN---RLNNVVVEDDAVAKEAIELLKRrkagratflplnkMRD 585
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1386 ELQHLRQSSEAEIQAKA-------QQVEAAER-------------SRMRIEEEIRVVRLQLETTERQ---RGGA-EGELQ 1441
Cdd:TIGR02169  586 ERRDLSILSEDGVIGFAvdlvefdPKYEPAFKyvfgdtlvvedieAARRLMGKYRMVTLEGELFEKSgamTGGSrAPRGG 665
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1442 ALRARAEEAEAQkrQAQEEAERLRRQVQDESQRKRQAEAELalrvkaeAEAAREKQRALQALDELRLQAEEAERRlRQAE 1521
Cdd:TIGR02169  666 ILFSRSEPAELQ--RLRERLEGLKRELSSLQSELRRIENRL-------DELSQELSDASRKIGEIEKEIEQLEQE-EEKL 735
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1522 AERARQVQVALETAQRSAEvELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERraqqqaeaerareeaerelERWQL 1601
Cdd:TIGR02169  736 KERLEELEEDLSSLEQEIE-NVKSELKELEARIEELEEDLHKLEEALNDLEARLSH-------------------SRIPE 795
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1602 KANEALRLRlqAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAvRQRELAEQELEKQRQLAEGTAQQRlAAEQELI 1681
Cdd:TIGR02169  796 IQAELSKLE--EEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQE-QRIDLKEQIKSIEKEIENLNGKKE-ELEEELE 871
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1682 RLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLE--AEAG 1759
Cdd:TIGR02169  872 ELEAALRDLESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDEEipEEEL 951
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1760 RFRELAEE----AARLRALAEEAKRQRQLAEEDAARQRAeaervLTEKLAaiseatRLKTEAEiALKEKEAENERLRRLA 1835
Cdd:TIGR02169  952 SLEDVQAElqrvEEEIRALEPVNMLAIQEYEEVLKRLDE-----LKEKRA------KLEEERK-AILERIEEYEKKKREV 1019

                   ....*
gi 254675251  1836 EDEAF 1840
Cdd:TIGR02169 1020 FMEAF 1024
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1066-1564 1.99e-14

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 80.47  E-value: 1.99e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1066 AEEVLKTHEEQLKEAQAVPATLQELEATKASLKKLRAqaeaqqpvfnTLRDELRGAQEVGERLQQRHGERDVEVERWRER 1145
Cdd:PRK02224  239 ADEVLEEHEERREELETLEAEIEDLRETIAETERERE----------ELAEEVRDLRERLEELEEERDDLLAEAGLDDAD 308
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1146 VTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQ---AVPIANCQAAREQLRQEKALLEE 1222
Cdd:PRK02224  309 AEAVEARREELEDRDEELRDRLEECRVAAQAHNEEAESLREDADDLEERAEELReeaAELESELEEAREAVEDRREEIEE 388
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1223 IERHGEKVEECQKFAkqyinaikdyelqlitykaqlepvasPAKKPKVQSGSESVIQEYVDLRTRYSELTTLtsqyikfI 1302
Cdd:PRK02224  389 LEEEIEELRERFGDA--------------------------PVDLGNAEDFLEELREERDELREREAELEAT-------L 435
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1303 SETLRRMEEEERLAEQQR-----------------AEERERLAEVEAALE----KQRQLAEAHAQAKAQAELEAQ----- 1356
Cdd:PRK02224  436 RTARERVEEAEALLEAGKcpecgqpvegsphvetiEEDRERVEELEAELEdleeEVEEVEERLERAEDLVEAEDRierle 515
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1357 ELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRvvRLQLETTERQRGGA 1436
Cdd:PRK02224  516 ERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNS--KLAELKERIESLER 593
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1437 EGELQALRARAE---EAEAQKRQAQEEAERLRR-QVQDESQRKRQAEAELAlrvKAEAEAARE-KQRALQALdelrlqaE 1511
Cdd:PRK02224  594 IRTLLAAIADAEdeiERLREKREALAELNDERReRLAEKRERKRELEAEFD---EARIEEAREdKERAEEYL-------E 663
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 254675251 1512 EAERRLRQAEAERARqVQVALETAQRSAE--VELQSKRASFAEKTAQLErTLQEE 1564
Cdd:PRK02224  664 QVEEKLDELREERDD-LQAEIGAVENELEelEELRERREALENRVEALE-ALYDE 716
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
583-761 2.70e-14

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 74.79  E-value: 2.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  583 LHGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESYSALMRELEMKEKKIKEIQNTGDRLLREDHPARPTVESFQ 662
Cdd:cd00176     2 LQQFLRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAEEIQERL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  663 AALQTQWSWMLQLCCCIEAHLKENTAYFQFFSDVREAEEQLQKLQETLRRKYSCDrtiTVTRLEDLLQDAQDEKEQLNEY 742
Cdd:cd00176    82 EELNQRWEELRELAEERRQRLEEALDLQQFFRDADDLEQWLEEKEAALASEDLGK---DLESVEELLKKHKELEEELEAH 158
                         170
                  ....*....|....*....
gi 254675251  743 KGHLSGLAKRAKAIVQLKP 761
Cdd:cd00176   159 EPRLKSLNELAEELLEEGH 177
CH_DIXDC1 cd21213
calponin homology (CH) domain found in Dixin and similar proteins; Dixin, also called ...
12-112 2.73e-14

calponin homology (CH) domain found in Dixin and similar proteins; Dixin, also called coiled-coil protein DIX1, coiled-coil-DIX1, or DIX domain-containing protein 1, is a positive effector of the Wnt signaling pathway. It activates WNT3A signaling via DVL2 and regulates JNK activation by AXIN1 and DVL2. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409062  Cd Length: 107  Bit Score: 71.56  E-value: 2.73e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   12 QKKTFTKWVNKHLIK--AQRHISDLYEDLRDGHNLISLLEVLSGDSL------PREKGRMRfhklQNVQIALDYLRHRQV 83
Cdd:cd21213     1 QLQAYVAWVNSQLKKrpGIRPVQDLRRDLRDGVALAQLIEILAGEKLpgidwnPTTDAERK----ENVEKVLQFMASKRI 76
                          90       100
                  ....*....|....*....|....*....
gi 254675251   84 KLVNIRNDDIADGNPKLTLGLIWTIILHF 112
Cdd:cd21213    77 RMHQTSAKDIVDGNLKAIMRLILALAAHF 105
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
1643-2226 3.75e-14

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 223496 [Multi-domain]  Cd Length: 908  Bit Score: 79.80  E-value: 3.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1643 KAEEQAVRQRELAEQELEKQR-QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQhEATAATQKRQELEAE 1721
Cdd:COG0419   189 ELEGQLSELLEDIEDLLEALEeELKELKKLEEIQEEQEEEELEQEIEALEERLAELEEEKERLE-ELKARLLEIESLELE 267
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1722 LAKVRAEmevllasKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARqRAEAERVLT 1801
Cdd:COG0419   268 ALKIREE-------ELRELERLLEELEEKIERLEELEREIEELEEELEGLRALLEELEELLEKLKSLEER-LEKLEEKLE 339
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1802 EKLAAISEATRLKTEAEIALKEKEAEN----ERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKAsESELERQKGL 1877
Cdd:COG0419   340 KLESELEELAEEKNELAKLLEERLKELeerlEELEKELEKALERLKQLEEAIQELKEELAELSAALEEI-QEELEELEKE 418
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1878 VEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELE---------LGRIRSNAEDtMRSKEQAELEAARQRQlaaeeeqrr 1948
Cdd:COG0419   419 LEELERELEELEEEIKKLEEQINQLESKELMIAELagagekcpvCGQELPEEHE-KELLELYELELEELEE--------- 488
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1949 reaeervqrslaaEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQ---EAAQKRLQAEEKAHAFVVQQ 2025
Cdd:COG0419   489 -------------ELSREKEEAELREEIEELEKELRELEEELIELLELEEALKEELEeklEKLENLLEELEELKEKLQLQ 555
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2026 REEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEArEQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRK 2105
Cdd:COG0419   556 QLKEELRQLEDRLQELKELLEELRLLRTRKEELEEL-RERLKELKKKLKELEERLSQLEELLQSLELSEAENELEEAEEE 634
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2106 EAEQEAARRAQAEQAALKQKQAADAEmEKHKKFAEQTLRQKAQVEQElttlrLQLEETDHQKSILDEELQRLKAEVTEAA 2185
Cdd:COG0419   635 LESELEKLNLQAELEELLQAALEELE-EKVEELEAEIRRELQRIENE-----EQLEEKLEELEQLEEELEQLREELEELL 708
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|.
gi 254675251 2186 RQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDN 2226
Cdd:COG0419   709 KKLGEIEQLIEELESRKAELEELKKELEKLEKALELLEELR 749
PTZ00121 PTZ00121
MAEBL; Provisional
1958-2651 4.51e-14

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 79.80  E-value: 4.51e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1958 SLAAEEEAARQRKVALEEVERLKAKVEEARRlRERAEQESARQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQE 2037
Cdd:PTZ00121 1075 SYKDFDFDAKEDNRADEATEEAFGKAEEAKK-TETGKAEEARKAEEAKKKAEDARKAEEARKAEDARKAEEARKAEDAKR 1153
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2038 QNMLDRLRSEaeaarraaeeaeeareqaereaaqsrKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQA 2117
Cdd:PTZ00121 1154 VEIARKAEDA--------------------------RKAEEARKAEDAKKAEAARKAEEVRKAEELRKAEDARKAEAARK 1207
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2118 EQAALKQKQAADAEMEKHK---KFAEQTlRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEE 2194
Cdd:PTZ00121 1208 AEEERKAEEARKAEDAKKAeavKKAEEA-KKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKA 1286
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2195 lfSVRVQMEELGKLKARIEAENraliLRDKDNTQRFLEE---EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRA 2271
Cdd:PTZ00121 1287 --EEKKKADEAKKAEEKKKADE----AKKKAEEAKKADEakkKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAE 1360
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2272 LAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQmAQQLveetqgfqRTLEAERQRQLEMSAEAErlK 2351
Cdd:PTZ00121 1361 AAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKK-ADEL--------KKAAAAKKKADEAKKKAE--E 1429
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2352 LRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKvtlvqtleiQRQQSDHDAERLREAiAELEREKEKLKQEA 2431
Cdd:PTZ00121 1430 KKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAK---------KADEAKKKAEEAKKA-DEAKKKAEEAKKKA 1499
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2432 KLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQ 2511
Cdd:PTZ00121 1500 DEAKKAAEAKKKADEAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMA 1579
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2512 ELMAsmEEARRRQREAEEGVRRKQEElqhlEQQRQQQEKLLAEENQRLRERLQRLEEEHRAAlahSEIATTQAASTKALP 2591
Cdd:PTZ00121 1580 LRKA--EEAKKAEEARIEEVMKLYEE----EKKMKAEEAKKAEEAKIKAEELKKAEEEKKKV---EQLKKKEAEEKKKAE 1650
                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675251 2592 NGRDAPDGPSVEAEPEY--TFEGLRQKVPAQQLQEAGILSQEELQRLAQGHTTVAELTQRED 2651
Cdd:PTZ00121 1651 ELKKAEEENKIKAAEEAkkAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEA 1712
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1339-1709 5.19e-14

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 79.01  E-value: 5.19e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1339 QLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQsseAEIQAKAQQVeaAERSRMRIEEE 1418
Cdd:pfam17380  273 QLLHIVQHQKAVSERQQQEKFEKMEQERLRQEKEEKAREVERRRKLEEAEKARQ---AEMDRQAAIY--AEQERMAMERE 347
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1419 IRVVRLQLEttERQRggaegELQALRaraEEAEAQKRQAQEEAERLRRQVQDESQRKRQaEAELALRVK-AEAEAAREKQ 1497
Cdd:pfam17380  348 RELERIRQE--ERKR-----ELERIR---QEEIAMEISRMRELERLQMERQQKNERVRQ-ELEAARKVKiLEEERQRKIQ 416
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1498 RALQALDELRLQAEEA-ERRLRQAEAERARqvqvaletaqrsaevELQSKRASFAEKTAQLERTLQEEhvtvaqlreeae 1576
Cdd:pfam17380  417 QQKVEMEQIRAEQEEArQREVRRLEEERAR---------------EMERVRLEEQERQQQVERLRQQE------------ 469
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1577 rraqqqaeAERAREEAERELE-RWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQavrQRELA 1655
Cdd:pfam17380  470 --------EERKRKKLELEKEkRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEE---RRREA 538
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251  1656 EQELEKQRQLAE--GTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEAT 1709
Cdd:pfam17380  539 EEERRKQQEMEErrRIQEQMRKATEERSRLEAMEREREMMRQIVESEKARAEYEAT 594
CH_SMTNL1 cd21260
calponin homology (CH) domain found in smoothelin-like protein 1; Smoothelin-like protein 1 ...
129-230 5.43e-14

calponin homology (CH) domain found in smoothelin-like protein 1; Smoothelin-like protein 1 (SMTNL1), also called calponin homology-associated smooth muscle protein (CHASM), plays a role in the regulation of contractile properties of both striated and smooth muscles. It can bind to calmodulin and tropomyosin. When it is unphosphorylated, SMTNL1 may inhibit myosin dephosphorylation. SMTNL1 contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409109  Cd Length: 116  Bit Score: 71.27  E-value: 5.43e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  129 KEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED 208
Cdd:cd21260     3 KNMLLEWCRAKTRGYEHVDIQNFSSSWSSGMAFCALIHKFFPDAFDYAELDPANRRHNFTLAFSTAEKHADCAPLLEVED 82
                          90       100
                  ....*....|....*....|...
gi 254675251  209 -VDVPQPDEKSIITYVSSLYDAM 230
Cdd:cd21260    83 mVRMSVPDSKCVYTYIQELYRSL 105
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1107-2017 5.76e-14

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 426331 [Multi-domain]  Cd Length: 1081  Bit Score: 79.05  E-value: 5.76e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1107 QQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQA----------VLAQTDVRQRELEQLGRQLRY 1176
Cdd:pfam01576    3 QEEEMQAKEEELQKVKEKQQKAESELKELEKKHQQLCEEKNILAEQLQAetelfaeaeeMRARLAARKQELEEILHELEA 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1177 YRESADPLSAWLQDAKRRQEQiqavpiaNCQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKA 1256
Cdd:pfam01576   83 RLEEEEERSQQLQNEKKKMQQ-------HIQDLEEQLEEEEAARQKLQLEKVTTEAKIKKMEEDILLLEDQNNKLQKERK 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1257 QLEPVASpakkpkvqsgseSVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLaeQQRAEERERLAEVEAAlEK 1336
Cdd:pfam01576  156 LLEERIS------------EFTSNLAEEEEKSKSLNKLKNKHEAMISDLEDRLKKEEKG--RQELEKAKRKLEGESS-DL 220
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1337 QRQLAEAHAQAK------AQAELEAQELQRRMQEEVARREEaavdAQQQKRSIQEELQHLRQSSEAEIQAKAQqveaAER 1410
Cdd:pfam01576  221 QEQIAELQAQIAelraqlAKKEEELQAALARLEEETAQKNA----ALKKLRELEAQLSELQEDLESERAARAK----AEK 292
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1411 SRMRIEEEIRVVRLQLE----TTERQrggaegelQALRARAE-EAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELalr 1485
Cdd:pfam01576  293 QRRDLGEELEALKTELEdtldTTAAQ--------QELRSKREqEVTELKKALEEETRSHEAQLQEMRQKHTQALEEL--- 361
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1486 vkaeAEAAREKQRALQALDELRlQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEktAQLERTLQEEH 1565
Cdd:pfam01576  362 ----TEQLEQAKRNKASLEKAK-QALESENAELQAELRSLQQAKQDSEHKRKKLEGQLQELQSRLSE--SERQRAELAEK 434
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1566 VTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEalrlRLQAEEVAQQKSLA----QADAEKQKEEAEREARRR 1641
Cdd:pfam01576  435 LSKLQSELESVSSLLNEAEGKNIKLSKDVSSLESQLQDTQ----ELLQEETRQKLNLSsrlrQLEDEKNSLQEQLEEEEE 510
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1642 GKAE---EQAVRQRELAE--QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHE---ATAATQ 1713
Cdd:pfam01576  511 AKRNverQLQTLQAQLSDlkKKLEEDAGAVEALEEGRKRLQRELEALTQRLEEKAAAYDKLEKTKNRLQQElddLLVDLD 590
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1714 KRQELEAELAKVRAEMEVLLaskarAEEESRSTS-EKSKQRLEAEAgrfRELAEEAARLRALAEEAKRQRQLAEEDAARQ 1792
Cdd:pfam01576  591 HQRQLVSNLEKKQKKFDQML-----AEEKAISARyAEERDRAEAEA---REKETKALSLARALEEALDAKEELERQNKQL 662
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1793 RAEAERVLTEKLAA---ISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKASEs 1869
Cdd:pfam01576  663 RAEMEDLVSSKDDVgknVHELERSKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFERDLQARDEQGE- 741
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1870 elERQKGLVedtlRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQRQLAAEEEQRRR 1949
Cdd:pfam01576  742 --EKRRQLV----KQVRELEAELEDERKQRAQAVAAKKKLELDLKELEAQIEAANKGRDEAVKQLKKLQAQMKDLQRELD 815
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251  1950 EAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESAR-QLQLAQEAAQKRLQAEEK 2017
Cdd:pfam01576  816 EARASRDEIFAQSKESEKKLKSLEAELLQLQEDLAAAERARRQAQQERDElAEEIASGNSGKSALLDEK 884
CH_FLN_rpt2 cd21230
second calponin homology (CH) domain found in filamins; The filamin family includes filamin-A ...
127-224 7.10e-14

second calponin homology (CH) domain found in filamins; The filamin family includes filamin-A (FLN-A), filamin-B (FLN-B) and filamin-C (FLN-C). Filamins function to anchor various transmembrane proteins to the actin cytoskeleton. FLN-A is also called actin-binding protein 280 (ABP-280), alpha-filamin, endothelial actin-binding protein, filamin-1, or non-muscle filamin. It promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. It also serves as a scaffold for a wide range of cytoplasmic signaling proteins. FLN-B is also called ABP-278, ABP-280 homolog, actin-binding-like protein, beta-filamin, filamin homolog 1 (Fh1), filamin-3, thyroid autoantigen, truncated actin-binding protein, or truncated ABP. It connects cell membrane constituents to the actin cytoskeleton and may also promote orthogonal branching of actin filaments as well as link actin filaments to membrane glycoproteins. FLN-C, also called FLNc, ABP-280-like protein, ABP-L, actin-binding-like protein, filamin-2, or gamma-filamin, is a muscle-specific filamin that plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. It may be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. FLN-C is critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. Members of this family contain two copies of the CH domain. The model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409079  Cd Length: 103  Bit Score: 70.49  E-value: 7.10e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGyqgLRCDNFTTSWRDGRLFNAIIHRHKPMLI----DMNKVYRqtnLENLDQAFSVAERDLGVTR 202
Cdd:cd21230     1 TPKQRLLGWIQNKIPQ---LPITNFTTDWNDGRALGALVDSCAPGLCpdweTWDPNDA---LENATEAMQLAEDWLGVPQ 74
                          90       100
                  ....*....|....*....|..
gi 254675251  203 LLDPEDVDVPQPDEKSIITYVS 224
Cdd:cd21230    75 LITPEEIINPNVDEMSVMTYLS 96
CH_CYTSA cd21256
calponin homology (CH) domain found in cytospin-A; Cytospin-A, also called renal carcinoma ...
127-227 7.44e-14

calponin homology (CH) domain found in cytospin-A; Cytospin-A, also called renal carcinoma antigen NY-REN-22, or sperm antigen with calponin homology and coiled-coil domains 1-like, or SPECC1-like protein (SPECC1L), is involved in cytokinesis and spindle organization. It may play a role in actin cytoskeleton organization and microtubule stabilization and hence, is required for proper cell adhesion and migration. Cytospin-A contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409105  Cd Length: 119  Bit Score: 70.87  E-value: 7.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAErDLGVTRLLDP 206
Cdd:cd21256    14 SKRNALLKWCQKKTEGYQNIDITNFSSSWNDGLAFCALLHTYLPAHIPYQELNSQDKRRNFTLAFQAAE-SVGIKSTLDI 92
                          90       100
                  ....*....|....*....|..
gi 254675251  207 ED-VDVPQPDEKSIITYVSSLY 227
Cdd:cd21256    93 NEmVRTERPDWQSVMTYVTAIY 114
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3021-3059 2.04e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 66.98  E-value: 2.04e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3021 LLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPELHEKL 3059
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
2148-2579 3.53e-13

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 223496 [Multi-domain]  Cd Length: 908  Bit Score: 76.34  E-value: 3.53e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2148 QVEQELTTLRLQLEETDHQKSI-LDEELQRLKAEVTEAARQRSQVEEElfsvrvqMEELGKLKARIEaENRALILRDKDN 2226
Cdd:COG0419   200 DIEDLLEALEEELKELKKLEEIqEEQEEEELEQEIEALEERLAELEEE-------KERLEELKARLL-EIESLELEALKI 271
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2227 TQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELA 2304
Cdd:COG0419   272 REEELRELERLLEELEEKIERLEELEREIEELEEELEGlrALLEELEELLEKLKSLEERLEKLEEKLEKLESELEELAEE 351
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2305 QEQARRLQEDKEQMAQQLVEETQGF-QRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEdAQRFRKQAEEIGEKLH 2383
Cdd:COG0419   352 KNELAKLLEERLKELEERLEELEKElEKALERLKQLEEAIQELKEELAELSAALEEIQEELEE-LEKELEELERELEELE 430
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2384 RTELATQEKVTLVQTLEIQRQQ------------SDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTvqqeqiLQ 2451
Cdd:COG0419   431 EEIKKLEEQINQLESKELMIAElagagekcpvcgQELPEEHEKELLELYELELEELEEELSREKEEAELREE------IE 504
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2452 ETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEGV 2531
Cdd:COG0419   505 ELEKELRELEEELIELLELEEALKEELEEKLEKLENLLEELEELKEKLQLQQLKEELRQLEDRLQELKELLEELRLLRTR 584
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*...
gi 254675251 2532 RRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSEI 2579
Cdd:COG0419   585 KEELEELRERLKELKKKLKELEERLSQLEELLQSLELSEAENELEEAE 632
mukB PRK04863
chromosome partition protein MukB;
1113-1938 3.72e-13

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 76.53  E-value: 3.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1113 TLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAV-----LAQTDVRQRelEQLGRqlryYRESADPLSAw 1187
Cdd:PRK04863  290 ELRRELYTSRRQLAAEQYRLVEMARELAELNEAESDLEQDYQAAsdhlnLVQTALRQQ--EKIER----YQADLEELEE- 362
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1188 lqdakRRQEQIQAVPIANCQAAREQLRQEKAlLEEIER-------HGEKVEECQKFAKQYINAIKDYE-LQLITYKAQLE 1259
Cdd:PRK04863  363 -----RLEEQNEVVEEADEQQEENEARAEAA-EEEVDElksqladYQQALDVQQTRAIQYQQAVQALErAKQLCGLPDLT 436
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1260 PVASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERlaeveaALEKQRQ 1339
Cdd:PRK04863  437 ADNAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQFEQAYQLVRKIAGEVSRSEAWDVARELLR------RLREQRH 510
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1340 LAEAHAQAKAQ-AELEAQELQRRMQEEVARReeaAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEE 1418
Cdd:PRK04863  511 LAEQLQQLRMRlSELEQRLRQQQRAERLLAE---FCKRLGKNLDDEDELEQLQEELEARLESLSESVSEARERRMALRQQ 587
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1419 IRvvrlqletterqrggaegELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEAELALRVKAEAEAARE 1495
Cdd:PRK04863  588 LE------------------QLQARIQRLAARAPAWLAAQDALARLREQSGEEfedSQDVTEYMQQLLERERELTVERDE 649
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1496 KQRALQALDE--LRLQAEEAER--RLRQAeAERARQV-------QVALETA---------QRSAEVELQSKRAsfAEKTA 1555
Cdd:PRK04863  650 LAARKQALDEeiERLSQPGGSEdpRLNAL-AERFGGVllseiydDVSLEDApyfsalygpARHAIVVPDLSDA--AEQLA 726
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1556 QLERTLQE------------EHVTVAQLREEAERRAQQQAEAERAREEAERELERwqlKANEAL--RLRLQAEEVAQQks 1621
Cdd:PRK04863  727 GLEDCPEDlyliegdpdsfdDSVFSVEELEKAVVVKIADRQWRYSRFPEVPLFGR---AAREKRieQLRAEREELAER-- 801
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1622 LAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRqlaegtaQQRLAAEQELIRLRAETEQGEQQRQLLEEEL 1701
Cdd:PRK04863  802 YATLSFDVQKLQRLHQAFSRFIGSHLAVAFEADPEAELRQLN-------RRRVELERALADHESQEQQQRSQLEQAKEGL 874
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1702 ARL-QHEATAATQKRQELEAELAKVRAEMEvllaskaRAEEESRSTSEKSKQ--RLEAEAGRFRELAEEAARLRALAEEA 1778
Cdd:PRK04863  875 SALnRLLPRLNLLADETLADRVEEIREQLD-------EAEEAKRFVQQHGNAlaQLEPIVSVLQSDPEQFEQLKQDYQQA 947
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1779 KRQRQlaeedAARQRAEAervLTEklaAISEATRLKTEAEIALKEKEAE-NERLR-RLAEDEAfQRRRLEEQAALHKA-- 1854
Cdd:PRK04863  948 QQTQR-----DAKQQAFA---LTE---VVQRRAHFSYEDAAEMLAKNSDlNEKLRqRLEQAEQ-ERTRAREQLRQAQAql 1015
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1855 -DIEERLAQLRKASeselerqkglveDTLRQRRQ-VEEEIMALKVSF-----EKAAAGKAELELEL--GRIRSNAEDTMR 1925
Cdd:PRK04863 1016 aQYNQVLASLKSSY------------DAKRQMLQeLKQELQDLGVPAdsgaeERARARRDELHARLsaNRSRRNQLEKQL 1083
                         890
                  ....*....|...
gi 254675251 1926 SKEQAELEAARQR 1938
Cdd:PRK04863 1084 TFCEAEMDNLTKK 1096
CH_ASPM_rpt1 cd21223
first calponin homology (CH) domain found in abnormal spindle-like microcephaly-associated ...
30-109 5.49e-13

first calponin homology (CH) domain found in abnormal spindle-like microcephaly-associated protein (ASPM) and similar proteins; ASPM, also called abnormal spindle protein homolog, or Asp homolog, is involved in mitotic spindle regulation and coordination of mitotic processes. It may also have a preferential role in regulating neurogenesis. Members of this family contain two copies of the CH domain in the middle region. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409072  Cd Length: 113  Bit Score: 68.00  E-value: 5.49e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   30 HISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM----RFHKLQNVQIALDYLRHRQV----KLVNIRNDDIADGNPKLT 101
Cdd:cd21223    25 AVTNLAVDLRDGVRLCRLVELLTGDWSLLSKLRVpaisRLQKLHNVEVALKALKEAGVlrggDGGGITAKDIVDGHREKT 104

                  ....*...
gi 254675251  102 LGLIWTII 109
Cdd:cd21223   105 LALLWRII 112
CH_CYTSB cd21257
calponin homology (CH) domain found in cytospin-B; Cytospin-B, also called nuclear structure ...
127-227 6.76e-13

calponin homology (CH) domain found in cytospin-B; Cytospin-B, also called nuclear structure protein 5 (NSP5), or sperm antigen HCMOGT-1, or sperm antigen with calponin homology and coiled-coil domains 1 (SPECC1), is a novel fusion Cytospin-B that contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409106  Cd Length: 112  Bit Score: 67.75  E-value: 6.76e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAErDLGVTRLLDP 206
Cdd:cd21257     8 SKRNALLKWCQKKTEGYPNIDITNFSSSWSDGLAFCALLHTYLPAHIPYQELSSQDKKRNLLLAFQAAE-SVGIKPSLEL 86
                          90       100
                  ....*....|....*....|..
gi 254675251  207 ED-VDVPQPDEKSIITYVSSLY 227
Cdd:cd21257    87 SEmMYTDRPDWQSVMQYVAQIY 108
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The ...
1051-1901 6.84e-13

RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 75.78  E-value: 6.84e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1051 EKLKTISLVIRSTQGAEEVLKTHEEQLKEAQAVPATLQELEATKASLKKLRAQAEAQQ--PVFNTLRDELRGAQEVGERL 1128
Cdd:pfam02463  180 EETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEEriDLLQELLRDEQEEIESSKQE 259
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1129 QQRHGERDVEVERWR---ERVTQLLERWQAVLAqtdvrqRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAVPIAN 1205
Cdd:pfam02463  260 IEKEEEKLAQVLKENkeeEKEKKLQEEELKLLA------KEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKE 333
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1206 CQAAREQLRQEKALLEEIERHGEKVEEC-QKFAKQYINAIKDYELQLITYKAQLEPVASPAKKPKVQSGSESVIQEYVDL 1284
Cdd:pfam02463  334 KEEIEELEKELKELEIKREAEEEEEEELeKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLEL 413
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1285 RTRYSELTTLTSQYIKFISEtlrrmEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQE 1364
Cdd:pfam02463  414 ARQLEDLLKEEKKEELEILE-----EEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVKLQEQLEL 488
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1365 EVARREEAAVDAQQQKrsiqeelqhlrqSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALR 1444
Cdd:pfam02463  489 LLSRQKLEERSQKESK------------ARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSAT 556
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1445 ARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAER 1524
Cdd:pfam02463  557 ADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTK 636
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1525 ARQVQVALETaQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKAN 1604
Cdd:pfam02463  637 LKESAKAKES-GLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKL 715
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1605 EALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1684
Cdd:pfam02463  716 KLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEK 795
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1685 ----AETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR 1760
Cdd:pfam02463  796 lkaqEEELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLK 875
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1761 FRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKE--AENERLRRLAEDE 1838
Cdd:pfam02463  876 EEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELllEEADEKEKEENNK 955
                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251  1839 AFQRRRlEEQAALHKADIEERLAQLRKASESELERQKGLVEDtlrQRRQVEEEIMALKVSFEK 1901
Cdd:pfam02463  956 EEEEER-NKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELE---KERLEEEKKKLIRAIIEE 1014
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4275-4313 8.66e-13

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 65.05  E-value: 8.66e-13
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  4275 LLEAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMVDRI 4313
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
931-1496 1.01e-12

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 223496 [Multi-domain]  Cd Length: 908  Bit Score: 74.80  E-value: 1.01e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  931 QQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETRTVHRLRLPLDKDPARECAQRIAEQQKAQAEveglgkgvarlsa 1010
Cdd:COG0419   221 IQEEQEEEELEQEIEALEERLAELEEEKERLEELKARLLEIESLELEALKIREEELRELERLLEELE------------- 287
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1011 eaekvlalpepspaapTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKTHEEQLKEAQAVPATLQEL 1090
Cdd:COG0419   288 ----------------EKIERLEELEREIEELEEELEGLRALLEELEELLEKLKSLEERLEKLEEKLEKLESELEELAEE 351
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1091 EATKASLKKLRaqaeaqqpvFNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQL 1170
Cdd:COG0419   352 KNELAKLLEER---------LKELEERLEELEKELEKALERLKQLEEAIQELKEELAELSAALEEIQEELEELEKELEEL 422
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1171 GRQLRYYRESADPLSAWLQDAKRRQEQIQAV-------PIANCQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINA 1243
Cdd:COG0419   423 ERELEELEEEIKKLEEQINQLESKELMIAELagagekcPVCGQELPEEHEKELLELYELELEELEEELSREKEEAELREE 502
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1244 IKDYELQLITYKAQLEP--VASPAKKPKVQSGSESVIQEYVDLRTRYSElttLTSQYIKFISETLRRMEEEERLAEQQRA 1321
Cdd:COG0419   503 IEELEKELRELEEELIEllELEEALKEELEEKLEKLENLLEELEELKEK---LQLQQLKEELRQLEDRLQELKELLEELR 579
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1322 EERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRM---QEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEI 1398
Cdd:COG0419   580 LLRTRKEELEELRERLKELKKKLKELEERLSQLEELLQSLElseAENELEEAEEELESELEKLNLQAELEELLQAALEEL 659
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1399 QAKAQQVEAAERSrmriEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDesQRKRQA 1478
Cdd:COG0419   660 EEKVEELEAEIRR----ELQRIENEEQLEEKLEELEQLEEELEQLREELEELLKKLGEIEQLIEELESRKAE--LEELKK 733
                         570
                  ....*....|....*...
gi 254675251 1479 EAELALRVKAEAEAAREK 1496
Cdd:COG0419   734 ELEKLEKALELLEELREK 751
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1310-2017 1.06e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 75.10  E-value: 1.06e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1310 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAElEAQELQRRMQE----EVARREEAAVdaqQQKRSIQE 1385
Cdd:TIGR02169  169 DRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRREREKAE-RYQALLKEKREyegyELLKEKEALE---RQKEAIER 244
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1386 ELQHLRQS---SEAEIQAKAQQVEAAERSRMRIEEEIRVVrlqletterqrggAEGELQALRARAEEAEAqkrqaqeEAE 1462
Cdd:TIGR02169  245 QLASLEEElekLTEEISELEKRLEEIEQLLEELNKKIKDL-------------GEEEQLRVKEKIGELEA-------EIA 304
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1463 RLRRQVQDESQRKRQAEAELAlrvKAEAEaarekqralqaLDELRLQAEEAERRLRQAEAERArqvqvALETAQRSAEVE 1542
Cdd:TIGR02169  305 SLERSIAEKERELEDAEERLA---KLEAE-----------IDKLLAEIEELEREIEEERKRRD-----KLTEEYAELKEE 365
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1543 LQSKRASFAEKTAQLERTLQEehvtvaqlreeaerraqqqaeaeraREEAERELERWQLKANEALRLRLQAEEVAQQKSL 1622
Cdd:TIGR02169  366 LEDLRAELEEVDKEFAETRDE-------------------------LKDYREKLEKLKREINELKRELDRLQEELQRLSE 420
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1623 AQADAEKQkeeaeREARRRGKAEEQAVRqrELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELA 1702
Cdd:TIGR02169  421 ELADLNAA-----IAGIEAKINELEEEK--EDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELA 493
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1703 RLQHEATAATQ-----KRQELE------------AELAKVRAEMEVLLASKA----------------------RAEEES 1743
Cdd:TIGR02169  494 EAEAQARASEErvrggRAVEEVlkasiqgvhgtvAQLGSVGERYATAIEVAAgnrlnnvvveddavakeaiellKRRKAG 573
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1744 RST-----------SEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEE-DAARQRAEAERVLT------EKLA 1805
Cdd:TIGR02169  574 RATflplnkmrderRDLSILSEDGVIGFAVDLVEFDPKYEPAFKYVFGDTLVVEDiEAARRLMGKYRMVTlegelfEKSG 653
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1806 AI-----------SEATRLKTEA-EIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLR-KASESELE 1872
Cdd:TIGR02169  654 AMtggsraprggiLFSRSEPAELqRLRERLEGLKRELSSLQSELRRIENRLDELSQELSDASRKIGEIEKEiEQLEQEEE 733
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1873 RQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQAELeaaRQRQLAAEEEQRRREAE 1952
Cdd:TIGR02169  734 KLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRI---PEIQAELSKLEEEVSRI 810
                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251  1953 ERVQRSLAAEEEAARQRKVALE-EVERLKAKVE--EARRLRERAEQESARQLQLAQEAAQKRLQAEEK 2017
Cdd:TIGR02169  811 EARLREIEQKLNRLTLEKEYLEkEIQELQEQRIdlKEQIKSIEKEIENLNGKKEELEEELEELEAALR 878
CH_PLS_rpt3 cd21298
third calponin homology (CH) domain found in the plastin family; The plastin family includes ...
14-115 1.84e-12

third calponin homology (CH) domain found in the plastin family; The plastin family includes plastin-1, -2, and -3. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, or LC64P, or lymphocyte cytosolic protein 1 (LCP-1), is an actin-binding protein that plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is an actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Members of this family contain four copies of the CH domain. This model corresponds to the third CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409147  Cd Length: 117  Bit Score: 66.88  E-value: 1.84e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   14 KTFTKWVNKhlIKAQRHISDLYEDLRDGHNLISLLEVLSGDSL-------PREKGRMRFHKLQNVQIALDYLRHRQVKLV 86
Cdd:cd21298     9 KTYRNWMNS--LGVNPFVNHLYSDLRDGLVLLQLYDKIKPGVVdwsrvnkPFKKLGANMKKIENCNYAVELGKKLKFSLV 86
                          90       100
                  ....*....|....*....|....*....
gi 254675251   87 NIRNDDIADGNPKLTLGLIWTIILHFQIS 115
Cdd:cd21298    87 GIGGKDIYDGNRTLTLALVWQLMRAYTLS 115
CH_SF cd00014
calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding ...
129-228 2.02e-12

calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).


Pssm-ID: 409031  Cd Length: 103  Bit Score: 66.21  E-value: 2.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  129 KEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTN---LENLDQAFSVAER-DLGVTRLL 204
Cdd:cd00014     1 EEELLKWINEVLGEELPVSITDLFESLRDGVLLCKLINKLSPGSIPKINKKPKSPfkkRENINLFLNACKKlGLPELDLF 80
                          90       100
                  ....*....|....*....|....
gi 254675251  205 DPEDVdVPQPDEKSIITYVSSLYD 228
Cdd:cd00014    81 EPEDL-YEKGNLKKVLGTLWALAL 103
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3352-3390 2.53e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 63.51  E-value: 2.53e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3352 LLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPELHEKL 3390
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3097-3135 3.02e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 63.51  E-value: 3.02e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3097 LLDAQLSTGGIVDPSKSHRVPLDVAYARGYLDKETNRAL 3135
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
CH_jitterbug-like_rpt2 cd21229
second calponin homology (CH) domain found in Drosophila melanogaster protein jitterbug and ...
129-224 3.60e-12

second calponin homology (CH) domain found in Drosophila melanogaster protein jitterbug and similar proteins; Protein jitterbug (Jbug) is an actin-meshwork organizing protein. It is required to maintain the shape and cell orientation of the Drosophila notum epithelium during flight muscle attachment to tendon cells. Jbug contains three copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409078  Cd Length: 105  Bit Score: 65.49  E-value: 3.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  129 KEKLLLWSQRMVEGyqgLRCDNFTTSWRDGRLFNAIIHRHKPMLI-DMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPE 207
Cdd:cd21229     5 KKLMLAWLQAVLPE---LKITNFSTDWNDGIALSALLDYCKPGLCpNWRKLDPSNSLENCRRAMDLAKREFNIPMVLSPE 81
                          90
                  ....*....|....*..
gi 254675251  208 DVDVPQPDEKSIITYVS 224
Cdd:cd21229    82 DLSSPHLDELSGMTYLS 98
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
2693-2731 4.64e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 63.13  E-value: 4.64e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  2693 LLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPELHHKL 2731
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3930-3968 5.99e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 62.74  E-value: 5.99e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3930 LLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEFKDKL 3968
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3763-3801 6.67e-12

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 62.36  E-value: 6.67e-12
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3763 LLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDTHDQL 3801
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
CH_MICAL1 cd21196
calponin homology (CH) domain found in molecule interacting with CasL protein 1; MICAL-1, also ...
129-229 7.17e-12

calponin homology (CH) domain found in molecule interacting with CasL protein 1; MICAL-1, also called NEDD9-interacting protein with calponin homology and LIM domains, acts as a [F-actin]-monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2). MICAL-1 acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments. It also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L. MICAL-1 is a Rab effector protein that plays a role in vesicle trafficking. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409045  Cd Length: 106  Bit Score: 64.68  E-value: 7.17e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  129 KEKLLLWSQRMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERDLGVTRLLDPED 208
Cdd:cd21196     5 QEELLRWCQEQTAGYPGVHVSDLSSSWADGLALCALVYRLQPGLLEPSELQGLGALEATAWALKVAENELGITPVVSAQA 84
                          90       100
                  ....*....|....*....|.
gi 254675251  209 VdVPQPDEKSIITYVSSLYDA 229
Cdd:cd21196    85 V-VAGSDPLGLIAYLSHFHSA 104
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
1976-2484 9.80e-12

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 223496 [Multi-domain]  Cd Length: 908  Bit Score: 71.72  E-value: 9.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1976 VERLKAKVEEARRLRERAEQESARQLQLAQEAAqKRLQAEEKAHAFVVQQREEELQQTLQQEQNML-DRLRSEAEAARRA 2054
Cdd:COG0419   173 SELLKEVIKEAKAKIEELEGQLSELLEDIEDLL-EALEEELKELKKLEEIQEEQEEEELEQEIEALeERLAELEEEKERL 251
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2055 AEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEaarraqaeqaalkqkqaadAEMEK 2134
Cdd:COG0419   252 EELKARLLEIESLELEALKIREEELRELERLLEELEEKIERLEELEREIEELEEEL-------------------EGLRA 312
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2135 HKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQ--------RSQVEEELFSVRVQMEELG 2206
Cdd:COG0419   313 LLEELEELLEKLKSLEERLEKLEEKLEKLESELEELAEEKNELAKLLEERLKEleerleelEKELEKALERLKQLEEAIQ 392
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2207 KLKARIEAENRAL---------ILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLR--------------QLAE 2263
Cdd:COG0419   393 ELKEELAELSAALeeiqeeleeLEKELEELERELEELEEEIKKLEEQINQLESKELMIAELAgagekcpvcgqelpEEHE 472
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2264 EDLAQQRALAEKMLKEKMQAVQEATRLKAEA-ELLQQQKELAQEQARRLQEDKEQM---------AQQLVEETQGFQRTL 2333
Cdd:COG0419   473 KELLELYELELEELEEELSREKEEAELREEIeELEKELRELEEELIELLELEEALKeeleeklekLENLLEELEELKEKL 552
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2334 EAERQRQLEMSAEAERLKLRMAEMSRAQAR-AEEDAQRFRKQAEEIGEKLHRTELATQEKVTLvqtleIQRQQSDHDAER 2412
Cdd:COG0419   553 QLQQLKEELRQLEDRLQELKELLEELRLLRtRKEELEELRERLKELKKKLKELEERLSQLEEL-----LQSLELSEAENE 627
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251 2413 LREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQ--EQILQETQALQKSFLSEKDSLLQRERfIEQEKAKLEQL 2484
Cdd:COG0419   628 LEEAEEELESELEKLNLQAELEELLQAALEELEEkvEELEAEIRRELQRIENEEQLEEKLEE-LEQLEEELEQL 700
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
1391-2017 1.65e-11

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 71.02  E-value: 1.65e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1391 RQSSEAEIQAKAQQVEA--AERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAE----RL 1464
Cdd:pfam12128  209 DGVVPPKSRLNRQQVEHwiRDIQAIAGIMKIRPEFTKLQQEFNTLESAELRLSHLHFGYKSDETLIASRQEERQetsaEL 288
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1465 RRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVeLQ 1544
Cdd:pfam12128  289 NQLLRTLDDQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKA-LT 367
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1545 SKRASFAEKTAQLERTLQEEHVT-VAQLREEAERRAQQQAEAERAREEAERELE---RWQLKAN------EALRLRLQAE 1614
Cdd:pfam12128  368 GKHQDVTAKYNRRRSKIKEQNNRdIAGIKDKLAKIREARDRQLAVAEDDLQALEselREQLEAGklefneEEYRLKSRLG 447
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1615 EVAQQKSLAQADAEK--QKEEAEREARRRGKAEEQAVRQRELAEQELekqrqlaegtAQQRLAAEQELIRLRAETEQGEQ 1692
Cdd:pfam12128  448 ELKLRLNQATATPELllQLENFDERIERAREEQEAANAEVERLQSEL----------RQARKRRDQASEALRQASRRLEE 517
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1693 QRQLLEEelarLQHEATAATQKRQE-LEAELAKVRAEMEVLLASK--ARAEEESRSTSEKSKQRLEAEAGRFRELAEEAA 1769
Cdd:pfam12128  518 RQSALDE----LELQLFPQAGTLLHfLRKEAPDWEQSIGKVISPEllHRTDLDPEVWDGSVGGELNLYGVKLDLKRIDVP 593
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1770 RLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQA 1849
Cdd:pfam12128  594 EWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLRRLFDEKQSEKDKKNKAL 673
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1850 ALHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALKVSFEkaaagkAELELELGRIRSN--AEDTMRSK 1927
Cdd:pfam12128  674 AERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVE------GALDAQLALLKAAiaARRSGAKA 747
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1928 EQAELEAARQRQLAAE-EEQRRREAEERVQRSLAAEEEAARQRKVA------------LEEVERLKAKVEEARRLRERAE 1994
Cdd:pfam12128  748 ELKALETWYKRDLASLgVDPDVIAKLKREIRTLERKIERIAVRRQEvlryfdwyqetwLQRRPRLATQLSNIERAISELQ 827
                          650       660
                   ....*....|....*....|...
gi 254675251  1995 QESARQlqlaQEAAQKRLQAEEK 2017
Cdd:pfam12128  828 QQLARL----IADTKLRRAKLEM 846
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
991-2015 1.65e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 426331 [Multi-domain]  Cd Length: 1081  Bit Score: 70.96  E-value: 1.65e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   991 QQKAQAEVEGLGKGVARLSAE----AEKVLALPEPSPAAPTLRSELELTLGKLEQV-RSLSAIYLEKLKTISLVIRSTQG 1065
Cdd:pfam01576   21 QQKAESELKELEKKHQQLCEEknilAEQLQAETELFAEAEEMRARLAARKQELEEIlHELEARLEEEEERSQQLQNEKKK 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1066 AEEVLKTHEEQLKEAQAVPATLQ-ELEATKASLKKLRAQaeaqqpvFNTLRDELRGAQEVGERLQQRHGERDVEVERWRE 1144
Cdd:pfam01576  101 MQQHIQDLEEQLEEEEAARQKLQlEKVTTEAKIKKMEED-------ILLLEDQNNKLQKERKLLEERISEFTSNLAEEEE 173
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1145 RV---TQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLSAWLQDAkrrqeqiqavpIANCQAAREQLRQEKALLE 1221
Cdd:pfam01576  174 KSkslNKLKNKHEAMISDLEDRLKKEEKGRQELEKAKRKLEGESSDLQEQ-----------IAELQAQIAELRAQLAKKE 242
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1222 -EIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEpvASPAKKPKVQSGSESVIQEYVDLRTRYSEL--TTLTSQY 1298
Cdd:pfam01576  243 eELQAALARLEEETAQKNAALKKLRELEAQLSELQEDLE--SERAARAKAEKQRRDLGEELEALKTELEDTldTTAAQQE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1299 IKF-----ISETLRRMEEEERLAEQQRAEERER----LAEVEAALEKQRQLAEAHAQAKAQAELEAQELQrrmqEEVARR 1369
Cdd:pfam01576  321 LRSkreqeVTELKKALEEETRSHEAQLQEMRQKhtqaLEELTEQLEQAKRNKASLEKAKQALESENAELQ----AELRSL 396
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1370 EEAAVDAQQQKRSIQEELQhlrqsseaEIQAKAQQveaAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEE 1449
Cdd:pfam01576  397 QQAKQDSEHKRKKLEGQLQ--------ELQSRLSE---SERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVSS 465
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1450 AEAQKRQAQEEAERLRRQVQDESQRKRQAEAE---LALRVKAEAEAAREKQRALQALDelrLQAEEAERRLRQAEAerar 1526
Cdd:pfam01576  466 LESQLQDTQELLQEETRQKLNLSSRLRQLEDEknsLQEQLEEEEEAKRNVERQLQTLQ---AQLSDLKKKLEEDAG---- 538
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1527 qVQVALETAQRSAEVELQSKRASFAEKTAQ---LERT---LQEE--HVTVAQlreeaerraqqqaeaeRAREEAERELER 1598
Cdd:pfam01576  539 -AVEALEEGRKRLQRELEALTQRLEEKAAAydkLEKTknrLQQEldDLLVDL----------------DHQRQLVSNLEK 601
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1599 WQLKANEALrlrlqAEEVAQQKSLAQA--DAEKQKEEAEREARRRGKAEEQAVRQRElaeqELEKQRQLAEGTAQQRLAA 1676
Cdd:pfam01576  602 KQKKFDQML-----AEEKAISARYAEErdRAEAEAREKETKALSLARALEEALDAKE----ELERQNKQLRAEMEDLVSS 672
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1677 EQELIRLRAETEQG----EQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQ 1752
Cdd:pfam01576  673 KDDVGKNVHELERSkralEQQVEEMKTQLEELEDELQATEDAKLRLEVNMQALKAQFERDLQARDEQGEEKRRQLVKQVR 752
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1753 RLEAEagrfrelAEEAARLRALAEEAKRQRQLAEED-------AARQRAEA--------------ERVLTEKLAAISEAT 1811
Cdd:pfam01576  753 ELEAE-------LEDERKQRAQAVAAKKKLELDLKEleaqieaANKGRDEAvkqlkklqaqmkdlQRELDEARASRDEIF 825
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1812 RLKTEAEIALKEKEAE----------NERLRRLAEDEafqRRRLEEQAAL----------HKADIEERLAQLrkasESEL 1871
Cdd:pfam01576  826 AQSKESEKKLKSLEAEllqlqedlaaAERARRQAQQE---RDELAEEIASgnsgksalldEKRRLEARIAQL----EEEL 898
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1872 ERQKGLVE---DTLR----QRRQVEEEIMALKVSFEKAAAGKAELEL---ELGRIRSNAEDTMRSK-------------- 1927
Cdd:pfam01576  899 EEEQSNTEllnDRLRkltlQVEQLTTELAAERSTSQKSESARQQLERqnkELKAKLQEMEGTVKSKykssiaaleakiaq 978
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1928 --EQAELEaARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKvalEEVERLKAKVEEARRLRERAEQESARqlqlaQ 2005
Cdd:pfam01576  979 leEQLEQE-SRERQAANKLVRRTEKKLKEVLLQVEDERRNADQYK---DQAEKGNSRLKQLKRQLEEAEEEASR-----A 1049
                         1130
                   ....*....|
gi 254675251  2006 EAAQKRLQAE 2015
Cdd:pfam01576 1050 NAARRKLQRE 1059
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
2144-2377 2.15e-11

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227278 [Multi-domain]  Cd Length: 420  Bit Score: 69.37  E-value: 2.15e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2144 RQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEA---ENRALI 2220
Cdd:COG4942    38 KQLKQIQKEIAALEKKIREQQDQRAKLEKQLKSLETEIASLEAQLIETADDLKKLRKQIADLNARLNALEVqerEQRRRL 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2221 LRDKDNTQRFLEEEAEKMKQVAEEAARlsvAAQEAARLRQLAEEDLAQQRALAEKMlkeKMQAVQEATRLKAEAELLQQQ 2300
Cdd:COG4942   118 AEQLAALQRSGRNPPPALLVSPEDAQR---SVRLAIYYGALNPARAERIDALKATL---KQLAAVRAEIAAEQAELTTLL 191
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251 2301 KELAQEQAR--RLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEE 2377
Cdd:COG4942   192 SEQRAQQAKlaQLLEERKKTLAQLNSELSADQKKLEELRANESRLKNEIASAEAAAAKAREAAAAAEAAAARARAAEAK 270
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
927-1563 2.85e-11

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 70.38  E-value: 2.85e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   927 SRHYQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACEtrtvhrLRLPLDKDPARECAQRIAEQQKAQA-EVEGLGKGV 1005
Cdd:TIGR00618  162 SKEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLT------LRSQLLTLCTPCMPDTYHERKQVLEkELKHLREAL 235
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1006 ARLSAEAEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVlKTHEEQLKEAQAVPA 1085
Cdd:TIGR00618  236 QQTQQSHAYLTQKREAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHI-KAVTQIEQQAQRIHT 314
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1086 TLQELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVE-------------RWRERVTQLLER 1152
Cdd:TIGR00618  315 ELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREiscqqhtltqhihTLQQQKTTLTQK 394
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1153 WQAVLAQTDVRQRELEQLGRQLRYYR-------------ESADPLSAWLQDAKRRQEQIQAVPIANCQAAREQLRQEKAL 1219
Cdd:TIGR00618  395 LQSLCKELDILQREQATIDTRTSAFRdlqgqlahakkqqELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQ 474
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1220 LEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVA-----SPAKKPKVQSGSESVIQEYVDLRTRYSELTTL 1294
Cdd:TIGR00618  475 LQTKEQIHLQETRKKAVVLARLLELQEEPCPLCGSCIHPNPARqdidnPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSE 554
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1295 TSQyIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAV 1374
Cdd:TIGR00618  555 RKQ-RASLKEQMQEIQQSFSILTQCDNRSKEDIPNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLH 633
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1375 DAQQQKRsIQEELQHLRQssEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALraraEEAEAQK 1454
Cdd:TIGR00618  634 LQQCSQE-LALKLTALHA--LQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEML----AQCQTLL 706
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1455 RQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAeaarekqralQALDELRLQAEEAERRLRQAEAERARQVQVALET 1534
Cdd:TIGR00618  707 RELETHIEEYDREFNEIENASSSLGSDLAAREDALN----------QSLKELMHQARTVLKARTEAHFNNNEEVTAALQT 776
                          650       660       670
                   ....*....|....*....|....*....|.
gi 254675251  1535 AQRSAEV--ELQSKRASFAEKTAQLERTLQE 1563
Cdd:TIGR00618  777 GAELSHLaaEIQFFNRLREEDTHLLKTLEAE 807
mukB PRK04863
chromosome partition protein MukB;
1278-1776 3.86e-11

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 69.99  E-value: 3.86e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1278 IQEYVDLRTRYSELTTLTSQYIkfiSETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEahaqakaqaeleaqE 1357
Cdd:PRK04863  249 IRVTQSDRDLFKHLITESTNYV---AADYMRHANERRVHLEEALELRRELYTSRRQLAAEQYRLV--------------E 311
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1358 LQRRMQEEVARREEAAVDAQQQKrsiqeelQHLRQSSEAEIQAKA--QQVEAAERSRMRIEEEIRVVRLQLEtterqrgg 1435
Cdd:PRK04863  312 MARELAELNEAESDLEQDYQAAS-------DHLNLVQTALRQQEKieRYQADLEELEERLEEQNEVVEEADE-------- 376
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1436 aegelqalraRAEEAEAQKRQAQEEAERLRRQVQDESQR----------KRQAEAELAlRVKA-------EAEAAREKQR 1498
Cdd:PRK04863  377 ----------QQEENEARAEAAEEEVDELKSQLADYQQAldvqqtraiqYQQAVQALE-RAKQlcglpdlTADNAEDWLE 445
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1499 ALQA-LDELRLQAEEAERRLRQAEAERaRQVQVALETAQR-SAEVElqskRASFAEKTAQLERTLQEEHVTVAQLreeae 1576
Cdd:PRK04863  446 EFQAkEQEATEELLSLEQKLSVAQAAH-SQFEQAYQLVRKiAGEVS----RSEAWDVARELLRRLREQRHLAEQL----- 515
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1577 rraqqqaeaerareeaerelerwqlkanEALRLRLQAeevAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAE 1656
Cdd:PRK04863  516 ----------------------------QQLRMRLSE---LEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELE 564
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1657 QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQL---LEEELARLQHEATAATQKRQELEAELAKvraemevlL 1733
Cdd:PRK04863  565 ARLESLSESVSEARERRMALRQQLEQLQARIQRLAARAPAwlaAQDALARLREQSGEEFEDSQDVTEYMQQ--------L 636
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....
gi 254675251 1734 ASKARAEEESRSTSEKSKQRLEAEAGRFREL-AEEAARLRALAE 1776
Cdd:PRK04863  637 LERERELTVERDELAARKQALDEEIERLSQPgGSEDPRLNALAE 680
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
1618-1827 4.45e-11

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 68.29  E-value: 4.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1618 QQKSLAQADAEKQKEEaerearrrgKAEEQAVRQRELAEQELEKQRQLAegtaQQRLAAeQELIRLRAETEQGEQQRQLL 1697
Cdd:PRK09510   68 QQQQKSAKRAEEQRKK---------KEQQQAEELQQKQAAEQERLKQLE----KERLAA-QEQKKQAEEAAKQAALKQKQ 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1698 EEELARLQHEATAATQKRQELEAELAKVRAEMEvllASKARAEEESRSTSEKSKQRLEAEAgrfRELAEEAARLRALAEE 1777
Cdd:PRK09510  134 AEEAAAKAAAAAKAKAEAEAKRAAAAAKKAAAE---AKKKAEAEAAKKAAAEAKKKAEAEA---AAKAAAEAKKKAEAEA 207
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 254675251 1778 AKRQRQLAEEDAARQ-RAEAERVLTEKLAAISEATRLKTEAEIALKEKEAE 1827
Cdd:PRK09510  208 KKKAAAEAKKKAAAEaKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAE 258
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1346-2484 5.57e-11

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 426331 [Multi-domain]  Cd Length: 1081  Bit Score: 69.42  E-value: 5.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1346 QAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQhlrqsSEAEIQAKAQQVEAAERSRMRIEEEIrvvrlq 1425
Cdd:pfam01576    8 QAKEEELQKVKEKQQKAESELKELEKKHQQLCEEKNILAEQLQ-----AETELFAEAEEMRARLAARKQELEEI------ 76
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1426 letterqrggaegeLQALRARAEEAEAQKRQAQEEAERLRRQVQDESQrkrQAEAElalrvkaeaEAAREKqralqalde 1505
Cdd:pfam01576   77 --------------LHELEARLEEEEERSQQLQNEKKKMQQHIQDLEE---QLEEE---------EAARQK--------- 121
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1506 LRLQAEEAERRLRQAEAErarqvqVALETAQRSaevELQSKRASFAEKTAQLERTLQEEHVTV---AQLREEAERRAQQQ 1582
Cdd:pfam01576  122 LQLEKVTTEAKIKKMEED------ILLLEDQNN---KLQKERKLLEERISEFTSNLAEEEEKSkslNKLKNKHEAMISDL 192
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1583 AEAERAREEAERELERWQLKAN-EALRLRLQAEEVAQQ-----KSLAQADAEKQkeeaereaRRRGKAEEQAVRQRELAE 1656
Cdd:pfam01576  193 EDRLKKEEKGRQELEKAKRKLEgESSDLQEQIAELQAQiaelrAQLAKKEEELQ--------AALARLEEETAQKNAALK 264
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1657 QELEKQRQLAEgtAQQRLAAEqelirlRAETEQGEQQRQLLEEELARLQHEA-----TAATQkrQELEAelakvRAEMEV 1731
Cdd:pfam01576  265 KLRELEAQLSE--LQEDLESE------RAARAKAEKQRRDLGEELEALKTELedtldTTAAQ--QELRS-----KREQEV 329
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1732 LLASKArAEEESRSTSEKSKQRLEAEAGRFRELAEE---AARLRALAEEAK--------------RQRQLAEEDAARQRA 1794
Cdd:pfam01576  330 TELKKA-LEEETRSHEAQLQEMRQKHTQALEELTEQleqAKRNKASLEKAKqalesenaelqaelRSLQQAKQDSEHKRK 408
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1795 EAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAlhkadieerlaqlrkASESELERQ 1874
Cdd:pfam01576  409 KLEGQLQELQSRLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLSKDVS---------------SLESQLQDT 473
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1875 KGLVEDTLRQR-------RQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQ-----AELEAARQRqlaa 1942
Cdd:pfam01576  474 QELLQEETRQKlnlssrlRQLEDEKNSLQEQLEEEEEAKRNVERQLQTLQAQLSDLKKKLEEdagavEALEEGRKR---- 549
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1943 eeeqrrreaeervqrsLAAEEEAARQRkvaLEEVERLKAKVEEAR-RLRERAE-----QESARQLQLAQEAAQKR---LQ 2013
Cdd:pfam01576  550 ----------------LQRELEALTQR---LEEKAAAYDKLEKTKnRLQQELDdllvdLDHQRQLVSNLEKKQKKfdqML 610
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2014 AEEKA-HAFVVQQREEELQQTLQQEQNMLDRLRSEAEAarraaeeaeeareqaereaaqsRKQVEEAERLKQSAEEQAQA 2092
Cdd:pfam01576  611 AEEKAiSARYAEERDRAEAEAREKETKALSLARALEEA----------------------LDAKEELERQNKQLRAEMED 668
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2093 QAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEM---EKHKKFAEQTLRQ-KAQVEQELTTLRLQLEEtdhQKS 2168
Cdd:pfam01576  669 LVSSKDDVGKNVHELERSKRALEQQVEEMKTQLEELEDELqatEDAKLRLEVNMQAlKAQFERDLQARDEQGEE---KRR 745
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2169 ILDEELQRLKAEVTEAARQRSQveeeLFSVRVQME-ELGKLKARIEAENRAlilRDkdntqrfleeeaEKMKQVAEEAAR 2247
Cdd:pfam01576  746 QLVKQVRELEAELEDERKQRAQ----AVAAKKKLElDLKELEAQIEAANKG---RD------------EAVKQLKKLQAQ 806
                          970       980       990      1000      1010      1020      1030      1040
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2248 LSVAAQEAARLRQLAEEDLAQQRAlAEKMLKekmqavqeatrlKAEAELLQQQKELA-QEQARR-LQEDKEQMAQQLVEE 2325
Cdd:pfam01576  807 MKDLQRELDEARASRDEIFAQSKE-SEKKLK------------SLEAELLQLQEDLAaAERARRqAQQERDELAEEIASG 873
                         1050      1060      1070      1080      1090      1100      1110      1120
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2326 TQGfqRTLEAERQRQLEMsaeaeRLKLRMAEMSRAQARAEEDAQRFRK---QAEEIGeklhrTELATQEkvTLVQTLEIQ 2402
Cdd:pfam01576  874 NSG--KSALLDEKRRLEA-----RIAQLEEELEEEQSNTELLNDRLRKltlQVEQLT-----TELAAER--STSQKSESA 939
                         1130      1140      1150      1160      1170      1180      1190      1200
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2403 RQQSDHDAERLREAIAELERE-KEKLKQ-----EAKLLQLKSEEMQTVQQEQilQETQALQKSFLSEKDSLLQRE---RF 2473
Cdd:pfam01576  940 RQQLERQNKELKAKLQEMEGTvKSKYKSsiaalEAKIAQLEEQLEQESRERQ--AANKLVRRTEKKLKEVLLQVEderRN 1017
                         1210
                   ....*....|.
gi 254675251  2474 IEQEKAKLEQL 2484
Cdd:pfam01576 1018 ADQYKDQAEKG 1028
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
1284-1940 6.07e-11

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 69.01  E-value: 6.07e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1284 LRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLaEVEAALEKQRQLAEAHAQAKAQ---AELEAQELQR 1360
Cdd:pfam07111   53 LELEGSQALSQQAELISRQLQELRRLEEEVRLLRETSLQQKMRL-EAQAMELDALAVAEKAGQAEAEglrAALAGAEMVR 131
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1361 RMQEEVARREeaavdAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSrmrieeeirvvrlqLETTERQRGGAEGEL 1440
Cdd:pfam07111  132 KNLEEGSQRE-----LEEIQRLHQEQLSSLTQAHEEALSSLTSKAEGLEKS--------------LNSLETKRAGEAKQL 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1441 QalraraeeaeaqkrQAQEEAERLRRQVqdeSQRKRQAEAELALrvkaeAEAAReKQRALQALDELRLQAEEAERRLRQA 1520
Cdd:pfam07111  193 A--------------EAQKEAELLRKQL---SKTQEELEAQVTL-----VESLR-KYVGEQVPPEVHSQTWELERQELLD 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1521 EAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVAQLreeaerraqqqaeaeraREEAERELERWQ 1600
Cdd:pfam07111  250 TMQHLQEDRADLQATVELLQVRVQSLTHMLALQEEELTRKIQPSDSLEPEF-----------------PKKCRSLLNRWR 312
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1601 LKANeALRLRLQAEEVAQQKSLAQADAEkqkeEAEREARRRGKAEEQAVRQRELAEQ--ELEKQRQLAEGTAQQRLAAEQ 1678
Cdd:pfam07111  313 EKVF-ALMVQLKAQDLEHRDSVKQLRGQ----VAELQEQVTSQSQEQAILQRALQDKaaEVEVERMSAKGLQMELSRAQE 387
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1679 ELIRLRAETEQGEQQRQL-----------LEEELARLQHEATAATQKRQELEAELAKVRAeMEVLLASK---ARAEEESR 1744
Cdd:pfam07111  388 ARRRQQQQTASAEEQLKFvvnamsstqiwLETTMTRVEQAVARIPSLSNRLSYAVRKVHT-IKGLMARKvalAQLRQESC 466
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1745 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQlAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEK 1824
Cdd:pfam07111  467 PPPPPAPPVDADLSLELEQLREERNRLDAELQLSAHLIQ-QEVGRAREQGEAERQQLSEVAQQLEQELQRAQESLASVGQ 545
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1825 EAENER--LRRLAEDEAFQRRRLEEQAALHKADIEERLAQLrkasESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKA 1902
Cdd:pfam07111  546 QLEVARqgQQESTEEAASLRQELTQQQEIYGQALQEKVAEV----ETRLREQLSDTKRRLNEARREQAKAVVSLRQIQHR 621
                          650       660       670
                   ....*....|....*....|....*....|....*...
gi 254675251  1903 AAGKAELELELGRIRSNAEdtmrsKEQAELEAARQRQL 1940
Cdd:pfam07111  622 ATQEKERNQELRRLQDEAR-----KEEGQRLARRVQEL 654
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4351-4389 6.43e-11

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 59.66  E-value: 6.43e-11
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  4351 FLEVQYLTGGLIEPDTPGRVSLDEALQRGTVDARTAQKL 4389
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
CH_FIMB_rpt3 cd21300
third calponin homology (CH) domain found in Saccharomyces cerevisiae fimbrin and similar ...
7-106 7.56e-11

third calponin homology (CH) domain found in Saccharomyces cerevisiae fimbrin and similar proteins; Fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the third CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409149  Cd Length: 119  Bit Score: 62.06  E-value: 7.56e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    7 ERDRvQKKTFTKWVNKhlIKAQRHISDLYEDLRDGHNLISLLEVLSGDS--------LPREKGRMRFHKLQNVQIALDYL 78
Cdd:cd21300     4 EGER-EARVFTLWLNS--LDVEPAVNDLFEDLRDGLILLQAYDKVIPGSvnwkkvnkAPASAEISRFKAVENTNYAVELG 80
                          90       100
                  ....*....|....*....|....*...
gi 254675251   79 RHRQVKLVNIRNDDIADGNPKLTLGLIW 106
Cdd:cd21300    81 KQLGFSLVGIQGADITDGSRTLTLALVW 108
mukB PRK04863
chromosome partition protein MukB;
1321-1837 1.01e-10

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 68.45  E-value: 1.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1321 AEERERLaeVEAALEKQRQLAEAHAQAKAQaeleaQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRqssEAEIQA 1400
Cdd:PRK04863  278 ANERRVH--LEEALELRRELYTSRRQLAAE-----QYRLVEMARELAELNEAESDLEQDYQAASDHLNLVQ---TALRQQ 347
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1401 KA--QQVEAAERSRMRIEEEIRVVRLQLEtterqrggaegelqalraRAEEAEAQKRQAQEEAERLRRQVQDESQRkrqa 1478
Cdd:PRK04863  348 EKieRYQADLEELEERLEEQNEVVEEADE------------------QQEENEARAEAAEEEVDELKSQLADYQQA---- 405
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1479 eaelalrVKAEAEAAREKQRALQALDELR-------LQAEEAERRLRQAEAERARQVQVALETAQRsaeVELQSKRASFA 1551
Cdd:PRK04863  406 -------LDVQQTRAIQYQQAVQALERAKqlcglpdLTADNAEDWLEEFQAKEQEATEELLSLEQK---LSVAQAAHSQF 475
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1552 EKTAQLERTLQEEHVtvaqlreeaerraqqqaeaerareeaerelerwqlkanealrlRLQAEEVAQQkslaqadaekqk 1631
Cdd:PRK04863  476 EQAYQLVRKIAGEVS-------------------------------------------RSEAWDVARE------------ 500
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1632 eeaerearrrgkAEEQAVRQRELAEQELEKQRQLAEgtAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAA 1711
Cdd:PRK04863  501 ------------LLRRLREQRHLAEQLQQLRMRLSE--LEQRLRQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEAR 566
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1712 tqkRQELEAELAKVRAEMEVLlaskaRAEEESrstSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEdAAR 1791
Cdd:PRK04863  567 ---LESLSESVSEARERRMAL-----RQQLEQ---LQARIQRLAARAPAWLAAQDALARLREQSGEEFEDSQDVTE-YMQ 634
                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 254675251 1792 QRAEAERVLTEKLAAISEA-TRLKTEAEIALKEKEAENERLRRLAED 1837
Cdd:PRK04863  635 QLLERERELTVERDELAARkQALDEEIERLSQPGGSEDPRLNALAER 681
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1507-1846 1.37e-10

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 67.84  E-value: 1.37e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1507 RLQAEEAER----RLRQAEAERARQVQV--ALETAQRSAEVELQSKRASFAEKtaqlERTLQEEHvtvaqlreeaerraq 1580
Cdd:pfam17380  287 RQQQEKFEKmeqeRLRQEKEEKAREVERrrKLEEAEKARQAEMDRQAAIYAEQ----ERMAMERE--------------- 347
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1581 qqaeaerareeaeRELERWQL----KANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGkAEEQAVRQRELAE 1656
Cdd:pfam17380  348 -------------RELERIRQeerkRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEA-ARKVKILEEERQR 413
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1657 QELEKQRQLAEGTAQQRLAAEQELIRLraETEQGEQQRQLLEEELARLQHeataaTQKRQELEAELAKVRAEMEVLLASK 1736
Cdd:pfam17380  414 KIQQQKVEMEQIRAEQEEARQREVRRL--EEERAREMERVRLEEQERQQQ-----VERLRQQEEERKRKKLELEKEKRDR 486
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1737 ARAEEESRSTSEKskqrlEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDaARQRAEAER---VLTEKLAAISEATRL 1813
Cdd:pfam17380  487 KRAEEQRRKILEK-----ELEERKQAMIEEERKRKLLEKEMEERQKAIYEEE-RRREAEEERrkqQEMEERRRIQEQMRK 560
                          330       340       350
                   ....*....|....*....|....*....|...
gi 254675251  1814 KTEAEIALKEKEAENERLRRLAEDEAfQRRRLE 1846
Cdd:pfam17380  561 ATEERSRLEAMEREREMMRQIVESEK-ARAEYE 592
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
1618-1813 2.11e-10

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 65.98  E-value: 2.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1618 QQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLL 1697
Cdd:PRK09510   70 QQKSAKRAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAAKAAAAAKAKA 149
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1698 EEELARLQHEATAATQKRQELEAELAKVRAEMEvllASKARAEEESRSTSEKSKQRLEAEAgrfRELAEEAARLRALAEE 1777
Cdd:PRK09510  150 EAEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAE---AKKKAEAEAAAKAAAEAKKKAEAEA---KKKAAAEAKKKAAAEA 223
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 254675251 1778 AKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRL 1813
Cdd:PRK09510  224 KAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEV 259
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1605-1857 3.09e-10

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 225177 [Multi-domain]  Cd Length: 548  Bit Score: 66.39  E-value: 3.09e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1605 EALRLRLQAEEVAQQKsLAQADAEKQKEEAEREARRRGKAEEQAVRQRE---LAEQELEKQRQLAEGTAQQRLAAEQEli 1681
Cdd:COG2268   209 DALGRRRIAQVLQDAE-IAENEAEKETEIAIAEANRDAKLVELEVEQQPagkTAEQTREVKIILAETEAEVAAWKAET-- 285
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1682 RLRAETEQGEQQRQLLEEELARLQheataATQKRQELEAElakvraEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRF 1761
Cdd:COG2268   286 RREAEQAEILAEQAIQEEKAQAEQ-----EVQHAKALEAR------EMRVGLIERQKETELEPQERSYFINAAQRQAQEE 354
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1762 RELAEEAARLRALAEEAKRQRqlAEEDAARQRAE------------------AERVLTEKLAAISEATRLKTEAEIALKE 1823
Cdd:COG2268   355 AKAAANIAEAIGAQAEAAVET--ARETEEAERAEqaalvaaaeaaeqeqveiAVRAEAAKAEAEAQAAEIKAEAEAIREK 432
                         250       260       270
                  ....*....|....*....|....*....|....
gi 254675251 1824 KEAENERLRRLAedEAFQRRRLEEQAALHKADIE 1857
Cdd:COG2268   433 GKAEAEAKRALA--EAIQVLGDAAAAELFKALVQ 464
CH_PLS_FIM_rpt1 cd21217
first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes ...
13-109 3.55e-10

first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes plastin and fimbrin. Plastin has three isoforms, plastin-1, -2, and -3, which are all actin-bundling proteins. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, LC64P, or lymphocyte cytosolic protein 1 (LCP-1), plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Fimbrin has been found in plants and fungi. Arabidopsis thaliana fimbrin (AtFIM) includes fimbrin-1, -2, -3, -4, and -5; they cross-link actin filaments (F-actin) in a calcium independent manner. They stabilize and prevent F-actin depolymerization mediated by profilin. They act as key regulators of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus. AtFIM5 is an actin bundling factor that is required for pollen germination and pollen tube growth. Fungal fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409066  Cd Length: 114  Bit Score: 60.28  E-value: 3.55e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   13 KKTFTKWVN---------KHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR-----FHKLQNVQIALDYL 78
Cdd:cd21217     3 KEAFVEHINslladdpdlKHLLPIDPDGDDLFEALRDGVLLCKLINKIVPGTIDERKLNKKkpkniFEATENLNLALNAA 82
                          90       100       110
                  ....*....|....*....|....*....|.
gi 254675251   79 RHRQVKLVNIRNDDIADGNPKLTLGLIWTII 109
Cdd:cd21217    83 KKIGCKVVNIGPQDILDGNPHLVLGLLWQII 113
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
2239-2457 3.74e-10

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 65.82  E-value: 3.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2239 KQVAEEAARLSVAAQEaarlRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQedkeQM 2318
Cdd:COG4372    81 PQLRALRTELGTAQGE----KRAAETEREAARSELQKARQEREAVRQELAAARQNLAKAQQELARLTKQAQDLQ----TR 152
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2319 AQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEE---DAQRFRKQAEEIGEKLHRTELATQEKVTL 2395
Cdd:COG4372   153 LKTLAEQRRQLEAQAQSLQASQKQLQASATQLKSQVLDLKLRSAQIEQeaqNLATRANAAQARTEELARRAAAAQQTAQA 232
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675251 2396 VQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQ 2457
Cdd:COG4372   233 IQQRDAQISQKAQQIAARAEQIRERERQLQRLETAQARLEQEVAQLEAYYQAYVRLRQQAAA 294
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1682-2236 3.78e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 66.60  E-value: 3.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1682 RLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEesrsTSEKSKQRLEAEAGRF 1761
Cdd:PRK02224  175 RLGVERVLSDQRGSLDQLKAQIEEKEEKDLHERLNGLESELAELDEEIERYEEQREQARE----TRDEADEVLEEHEERR 250
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1762 RELA---EEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKE---AENERLRRLA 1835
Cdd:PRK02224  251 EELEtleAEIEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREeleDRDEELRDRL 330
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1836 EDEAFQRRRLEEQA---ALHKADIEERLAQLRKAS---ESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAEL 1909
Cdd:PRK02224  331 EECRVAAQAHNEEAeslREDADDLEERAEELREEAaelESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNA 410
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1910 ELELGRIRSNAEDTmRSKE---QAELEAARQR------------------QLAAEEEQRRREAEERVQRSLAAEEEAARQ 1968
Cdd:PRK02224  411 EDFLEELREERDEL-REREaelEATLRTARERveeaealleagkcpecgqPVEGSPHVETIEEDRERVEELEAELEDLEE 489
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1969 RKVALEE-VERLKAKVEEARRLRERAEQESArqlqLAQEAAQKRLQAEEKAHAfvvqqreeelqqtlqqeqnmLDRLRSE 2047
Cdd:PRK02224  490 EVEEVEErLERAEDLVEAEDRIERLEERRED----LEELIAERRETIEEKRER--------------------AEELRER 545
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2048 AEAARRAAEEAEEAREQAereaaqsRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQA 2127
Cdd:PRK02224  546 AAELEAEAEEKREAAAEA-------EEEAEEAREEVAELNSKLAELKERIESLERIRTLLAAIADAEDEIERLREKREAL 618
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2128 ADAEMEKHKKFAEQTLRqKAQVEQELTTLRlqLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGK 2207
Cdd:PRK02224  619 AELNDERRERLAEKRER-KRELEAEFDEAR--IEEAREDKERAEEYLEQVEEKLDELREERDDLQAEIGAVENELEELEE 695
                         570       580       590
                  ....*....|....*....|....*....|
gi 254675251 2208 LKARIEA-ENRALILRDkdntqrfLEEEAE 2236
Cdd:PRK02224  696 LRERREAlENRVEALEA-------LYDEAE 718
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
1318-1884 6.79e-10

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 65.59  E-value: 6.79e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1318 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQeevarreeAAVDAQQQKRSIQEELQHLRQSSEAE 1397
Cdd:PRK10246  219 QSLTASLQVLTDEEKQLLTAQQQQQQSLNWLTRLDELQQEASRRQQ--------ALQQALAAEEKAQPQLAALSLAQPAR 290
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1398 I-----QAKAQQVEAAERSRMRIEEeirvVRLQLETTERQRggAEGELQALRARAEEAEAQKRQAQ--EEAERLR----- 1465
Cdd:PRK10246  291 QlrphwERIQEQSAALAHTRQQIEE----VNTRLQSTMALR--ARIRHHAAKQSAELQAQQQSLNTwlAEHDRFRqwnne 364
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1466 ---------RQVQDESQRKRQAEAELALRVK----------------AEAEAAREKQRAL-QALDELRLQAEEAERRLRQ 1519
Cdd:PRK10246  365 lagwraqfsQQTSDREQLRQWQQQLTHAEQKlnalpaitltltadevAAALAQHAEQRPLrQRLVALHGQIVPQQKRLAQ 444
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1520 AEAERARqvqvaLETAQRSAEVELQSKRASFAEKTAQLE--RTLQEEHVTVAQLREEAERRAQQQAEAE--RAREEAERE 1595
Cdd:PRK10246  445 LQVAIQN-----VTQEQTQRNAALNEMRQRYKEKTQQLAdvKTICEQEARIKDLEAQRAQLQAGQPCPLcgSTSHPAVEA 519
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1596 LERWQLKANEALRLRLQaEEVAQQKS-----LAQADAEKQKEEaerearrrgKAEEQAVRQRElAEQELEKQRQLAEGTA 1670
Cdd:PRK10246  520 YQALEPGVNQSRLDALE-KEVKKLGEegaalRGQLDALTKQLQ---------RDESEAQSLRQ-EEQALTQQWQAVCASL 588
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1671 QQRLAAEQELIRLRAETEQGEQQRQLLEEELArLQHEATAATQKRQELEAELAKVRAEMEVLLASKA------RAEEESR 1744
Cdd:PRK10246  589 NITLQPQDDIQPWLDAQEEHERQLRLLSQRHE-LQGQIAAHNQQIIQYQQQIEQRQQQLLTALAGYAltlpqeDEEASWL 667
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1745 STSEKSKQRLEAEAGRFRELAEEAARLRALAEeakrqrQLAEEDAArqRAEAERVLTEKLAAISEATrLKTEAEIALKEK 1824
Cdd:PRK10246  668 ATRQQEAQSWQQRQNELTALQNRIQQLTPLLE------TLPQSDDL--PHSEETVALDNWRQVHEQC-LSLHSQLQTLQQ 738
                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251 1825 EAENERlRRLAE-----DEAFQRRRLEEQAALHKADIEE----RLAQLRKASESELERQKGLVEDTLRQ 1884
Cdd:PRK10246  739 QDVLEA-QRLQKaqaqfDTALQASVFDDQQAFLAALLDEetltQLEQLKQNLENQRQQAQTLVTQTAQA 806
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
487-676 6.94e-10

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 62.08  E-value: 6.94e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  487 LRYLQDLLAWVEENQRRIDSAEWGVDLPSVEAQLGSHRGMHQSIEEFRAKIERARNDESQLSPATRGAY---RDCLGRLD 563
Cdd:cd00176     6 LRDADELEAWLSEKEELLSSTDYGDDLESVEALLKKHEALEAELAAHEERVEALNELGEQLIEEGHPDAeeiQERLEELN 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  564 LQYAKLLNSSKARLRSLE---SLHGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESYSALMRELEMKEKKIKEI 640
Cdd:cd00176    86 QRWEELRELAEERRQRLEealDLQQFFRDADDLEQWLEEKEAALASEDLGKDLESVEELLKKHKELEEELEAHEPRLKSL 165
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 254675251  641 QNTGDRLLREDHP-ARPTVESFQAALQTQWSWMLQLC 676
Cdd:cd00176   166 NELAEELLEEGHPdADEEIEEKLEELNERWEELLELA 202
CH_PARV_rpt2 cd21222
second calponin homology (CH) domain found in the parvin family; The parvin family includes ...
5-112 7.93e-10

second calponin homology (CH) domain found in the parvin family; The parvin family includes alpha-parvin, beta-parvin, and gamma-parvin. Alpha-parvin, also called actopaxin, calponin-like integrin-linked kinase-binding protein (CH-ILKBP), or matrix-remodeling-associated protein 2, plays a role in sarcomere organization and in smooth muscle cell contraction. It is required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Beta-parvin, also called affixin, is an adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases Cdc42 and Rac1 by guanine exchange factors, such as ARHGEF6. Both alpha-parvin and beta-parvin are involved in the reorganization of the actin cytoskeleton and the formation of lamellipodia, and both play roles in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. Gamma-parvin probably plays a role in the regulation of cell adhesion and cytoskeleton organization. Members of this family contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409071  Cd Length: 121  Bit Score: 59.52  E-value: 7.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    5 PDERDRVqKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLP----REKGRMRFHKLQNVQIALDYLRH 80
Cdd:cd21222    11 PEKLAEV-KELLLQFVNKHLAKLNIEVTDLATQFHDGVYLILLIGLLEGFFVPlheyHLTPSTDDEKLHNVKLALELMED 89
                          90       100       110
                  ....*....|....*....|....*....|..
gi 254675251   81 RQVKLVNIRNDDIADGNPKLTLGLIWTIILHF 112
Cdd:cd21222    90 AGISTPKIRPEDIVNGDLKSILRVLYSLFSKY 121
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1962-2583 8.77e-10

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 65.51  E-value: 8.77e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1962 EEEAARQRKVALEEVERLKAKVEEAR----RLRERAEQESARQLQLAQEAAQKRLQAEE-KAHAFVVQQREEELQQTLQQ 2036
Cdd:COG1196   220 AELRELELALLLAKLKELRKELEELEeelsRLEEELEELQEELEEAEKEIEELKSELEElREELEELQEELLELKEEIEE 299
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2037 EQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEaeqeaarraq 2116
Cdd:COG1196   300 LEGEISLLRERLEELENELEELEERLEELKEKIEALKEELEERETLLEELEQLLAELEEAKEELEEKLSA---------- 369
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2117 aeqaalkQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELF 2196
Cdd:COG1196   370 -------LLEELEELFEALREELAELEAELAEIRNELEELKREIESLEERLERLSERLEDLKEELKELEAELEELQTELE 442
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2197 SVRVQMEELGKLKARIEAENRAL--ILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2274
Cdd:COG1196   443 ELNEELEELEEQLEELRDRLKELerELAELQEELQRLEKELSSLEARLDRLEAEQRASQGVRAVLEALESGLPGVYGPVA 522
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2275 KMLKEK--------------------------MQAVQEATRLKA----------EAELLQQQKELAQ------------- 2305
Cdd:COG1196   523 ELIKVKekyetaleaalgnrlqavvveneevaKKAIEFLKENKAgratflpldrIKPLRSLKSDAAPgflglasdlidfd 602
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2306 --------------------EQARRLQEDKEQMA---------------------------------QQLVEETQGFQRT 2332
Cdd:COG1196   603 pkyepavrfvlgdtlvvddlEQARRLARKLRIKYrivtldgdlvepsgsitggsrnkrsslaqkrelKELEEELAELEAQ 682
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2333 LEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAER 2412
Cdd:COG1196   683 LEKLEEELKSLKNELRSLEDLLEELRRQLEELERQLEELKRELAALEEELEQLQSRLEELEEELEELEEELEELQERLEE 762
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2413 LREAIAELEREKEKLKQE-AKLLQLKSEEMQTVQQ-EQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQlfqdEVA 2490
Cdd:COG1196   763 LEEELESLEEALAKLKEEiEELEEKRQALQEELEElEEELEEAERRLDALERELESLEQRRERLEQEIEELEE----EIE 838
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2491 KAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEE---GVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLE 2567
Cdd:COG1196   839 ELEEKLDELEEELEELEKELEELKEELEELEAEKEELEDelkELEEEKEELEEELRELESELAELKEEIEKLRERLEELE 918
                         730
                  ....*....|....*.
gi 254675251 2568 EEHRAALAHSEIATTQ 2583
Cdd:COG1196   919 AKLERLEVELPELEEE 934
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
2223-2569 9.13e-10

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 65.14  E-value: 9.13e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2223 DKDNTQRFLEEEAEKMKQVAEEAARlsvaaqEAARLRQLAEEDLAQQRALAEkmlkekmqavqeatrlkaEAELLQQQKE 2302
Cdd:pfam17380  286 ERQQQEKFEKMEQERLRQEKEEKAR------EVERRRKLEEAEKARQAEMDR------------------QAAIYAEQER 341
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2303 LAQEQARRLQEDKEQmaqqlveetqgfQRTLEAERQRQLEMSAEAERlklrMAEMSRAQARAEEDAQRFRKQAEEIGE-K 2381
Cdd:pfam17380  342 MAMERERELERIRQE------------ERKRELERIRQEEIAMEISR----MRELERLQMERQQKNERVRQELEAARKvK 405
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2382 LHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEakllqlkseEMQTVQQEQILQETQALQKSFL 2461
Cdd:pfam17380  406 ILEEERQRKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRLE---------EQERQQQVERLRQQEEERKRKK 476
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2462 SEKDSLLQRERFIEQEKAKLEQLFQDEVAKAkqlreeqqrqqqQMEQEKQELMASMEEARRRQREAEEGVRRKQEELQHL 2541
Cdd:pfam17380  477 LELEKEKRDRKRAEEQRRKILEKELEERKQA------------MIEEERKRKLLEKEMEERQKAIYEEERRREAEEERRK 544
                          330       340
                   ....*....|....*....|....*...
gi 254675251  2542 EQQRqqqekllaEENQRLRERLQRLEEE 2569
Cdd:pfam17380  545 QQEM--------EERRRIQEQMRKATEE 564
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
1613-2016 9.74e-10

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 65.06  E-value: 9.74e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1613 AEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRlAAEQELIRLRAETEQGEQ 1692
Cdd:PRK02224  278 AEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEARREELEDRDEELRDRLEECRVAAQ-AHNEEAESLREDADDLEE 356
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1693 QRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLR 1772
Cdd:PRK02224  357 RAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREAELEATLR 436
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1773 ALAEEAKRQRQLAEE----DAARQRAEAERV--LTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAfQRRRLE 1846
Cdd:PRK02224  437 TARERVEEAEALLEAgkcpECGQPVEGSPHVetIEEDRERVEELEAELEDLEEEVEEVEERLERAEDLVEAED-RIERLE 515
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1847 EQAalhkADIEERLAQLRKASESELERQkglveDTLRQRRQVEEEIMALKvsfeKAAAGKAELELELGRIRSNAEDtmrs 1926
Cdd:PRK02224  516 ERR----EDLEELIAERRETIEEKRERA-----EELRERAAELEAEAEEK----REAAAEAEEEAEEAREEVAELN---- 578
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1927 KEQAELEAARQRqlaaeeeqrrreaeERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLA-- 2004
Cdd:PRK02224  579 SKLAELKERIES--------------LERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEfd 644
                         410
                  ....*....|....*.
gi 254675251 2005 ----QEAAQKRLQAEE 2016
Cdd:PRK02224  645 eariEEAREDKERAEE 660
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
2124-2430 1.01e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 65.09  E-value: 1.01e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2124 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEEtdhqksiLDEELQRLKAEVTEAARQRSQVEEEL------FS 2197
Cdd:TIGR02169  217 LKEKREYEGYELLKEKEALERQKEAIERQLASLEEELEK-------LTEEISELEKRLEEIEQLLEELNKKIkdlgeeEQ 289
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2198 VRVQmEELGKLKARIEaenralilrdkdNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRalaekml 2277
Cdd:TIGR02169  290 LRVK-EKIGELEAEIA------------SLERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEER------- 349
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2278 KEKMQAVQEATRLKAEAELLQQQkelAQEQARRLQEDKEQMAqQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEM 2357
Cdd:TIGR02169  350 KRRDKLTEEYAELKEELEDLRAE---LEEVDKEFAETRDELK-DYREKLEKLKREINELKRELDRLQEELQRLSEELADL 425
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251  2358 SRAQARAEEDAQRFRKQAEEIGEKLhrtELATQEKVTLVQTLEIQRQQsdhdAERLREAIAELEREKEKLKQE 2430
Cdd:TIGR02169  426 NAAIAGIEAKINELEEEKEDKALEI---KKQEWKLEQLAADLSKYEQE----LYDLKEEYDRVEKELSKLQRE 491
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1277-1842 1.04e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 65.09  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1277 VIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEaALEKQRQLAEAHAQAKAQAELEAQ 1356
Cdd:PRK03918  170 VIKEIKRRIERLEKFIKRTENIEELIKEKEKELEEVLREINEISSELPELREELE-KLEKEVKELEELKEEIEELEKELE 248
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1357 ELQRRMQEEvarrEEAAVDAQQQKRSIQEELQHLRQSSE--AEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRG 1434
Cdd:PRK03918  249 SLEGSKRKL----EEKIRELEERIEELKKEIEELEEKVKelKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEIN 324
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1435 GAEGELQAL---RARAEEAEAQKRQAQEEAERLRRQVQdESQRKRQAEAELAlRVKAEaEAAREKQRALQALDELRLQAE 1511
Cdd:PRK03918  325 GIEERIKELeekEERLEELKKKLKELEKRLEELEERHE-LYEEAKAKKEELE-RLKKR-LTGLTPEKLEKELEELEKAKE 401
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1512 EAERRLRQAEAERARQVQ---------VALETAQRSAEV----------------------ELQSKRASFAEKTAQLERT 1560
Cdd:PRK03918  402 EIEEEISKITARIGELKKeikelkkaiEELKKAKGKCPVcgrelteehrkelleeytaelkRIEKELKEIEEKERKLRKE 481
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1561 LQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARR 1640
Cdd:PRK03918  482 LRELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAEL 561
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1641 RGKAEEQAVRQRELaEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEA 1720
Cdd:PRK03918  562 EKKLDELEEELAEL-LKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEELAETEK 640
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1721 ELAKVRAEMEVLLasKARAEEESRSTSEKskqrleaeagrFRELAEEAARLRALAEEAKRQRQLAEEDAarqraeaeRVL 1800
Cdd:PRK03918  641 RLEELRKELEELE--KKYSEEEYEELREE-----------YLELSRELAGLRAELEELEKRREEIKKTL--------EKL 699
                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*
gi 254675251 1801 TEKLAAISEATRLKTEAEIALKEKEAENERLRR---LAEDEAFQR 1842
Cdd:PRK03918  700 KEELEEREKAKKELEKLEKALERVEELREKVKKykaLLKERALSK 744
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
2122-2638 1.11e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 65.08  E-value: 1.11e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2122 LKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQ 2201
Cdd:TIGR02168  231 VLRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRER 310
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2202 MEELGKLKARIEAEnRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKM 2281
Cdd:TIGR02168  311 LANLERQLEELEAQ-LEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVA 389
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2282 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVE-ETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRA 2360
Cdd:TIGR02168  390 QLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEaELKELQAELEELEEELEELQEELERLEEALEELREE 469
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2361 QARAEEDAQRFRKQAEEIGEKLHRTE-----------------------------LATQEKVT----------------- 2394
Cdd:TIGR02168  470 LEEAEQALDAAERELAQLQARLDSLErlqenlegfsegvkallknqsglsgilgvLSELISVDegyeaaieaalggrlqa 549
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2395 -LVQTLEIQRQ--QSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEE-----------------------MQTVQQEQ 2448
Cdd:TIGR02168  550 vVVENLNAAKKaiAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEgflgvakdlvkfdpklrkalsylLGGVLVVD 629
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2449 ILQETQALQKS------------------------FLSEKDSLLQRERFIEQEKAKLEQLfQDEVAKAKQLREEQQRQQQ 2504
Cdd:TIGR02168  630 DLDNALELAKKlrpgyrivtldgdlvrpggvitggSAKTNSSILERRREIEELEEKIEEL-EEKIAELEKALAELRKELE 708
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2505 QMEQEKQELMASMEEARRRQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSEIATTQA 2584
Cdd:TIGR02168  709 ELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELE 788
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251  2585 ASTKALPNGRDAPDGPSVEAEPEYT---FEGLRQKVPAQQLQEAGILSQEELQRLAQ 2638
Cdd:TIGR02168  789 AQIEQLKEELKALREALDELRAELTllnEEAANLRERLESLERRIAATERRLEDLEE 845
PLEC smart00250
Plectin repeat;
4273-4310 1.45e-09

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 55.95  E-value: 1.45e-09
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 254675251   4273 QRLLEAQACTGGIIDPSTGERFPVTEAVNKGLVDKIMV 4310
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
1332-1564 1.63e-09

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 64.20  E-value: 1.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1332 AALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVD-AQQQKRSIQEELQHLR--QSSEAEIQAKAQQVEAA 1408
Cdd:PRK05035  436 AEIRAIEQEKKKAEEAKARFEARQARLEREKAAREARHKKAAEArAAKDKDAVAAALARVKakKAAATQPIVIKAGARPD 515
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1409 ERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKA 1488
Cdd:PRK05035  516 NSAVIAAREARKAQARARQAEKQAAAAADPKKAAVAAAIARAKAKKAAQQAANAEAEEEVDPKKAAVAAAIARAKAKKAA 595
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 1489 EAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASfAEKTAQLERTLQEE 1564
Cdd:PRK05035  596 QQAASAEPEEQVAEVDPKKAAVAAAIARAKAKKAEQQANAEPEEPVDPRKAAVAAAIARAK-ARKAAQQQANAEPE 670
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 ...
1325-1798 2.15e-09

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 substr. MG1655 [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 225638 [Multi-domain]  Cd Length: 1480  Bit Score: 64.14  E-value: 2.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1325 ERLAEVEAALEKQRQLAEAHAQAKAQaeleaQELQRRMQEEVARREEAAVDAQQQKRSIQEELQhLRQSSEAEIQAKAQQ 1404
Cdd:COG3096   280 ERRVHLDQALEFRRELYTSRQQLAAE-----QYRHVDMSRELAELNGAEGDLEADYQAASDHLN-LVQTALRQQEKIERY 353
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1405 VEAAERSRMRIEEEIRVVRlqlETTERQrggaegelqalraraEEAEAQKRQAQEEAERLRRQVQDeSQRKRQAEAELAL 1484
Cdd:COG3096   354 QADLEELTIRLEEQNEVVE---EANERQ---------------EENEARAEAAELEVDELKSQLAD-YQQALDVQQTRAI 414
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1485 RVKaEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETaqrsaEVELQSKRASFAEKTAQLERTLQEE 1564
Cdd:COG3096   415 QYQ-QAIAALERAKELCHLPDLTADSAEEWLETFQAKEEEATEKLLSLEQ-----KMSMAQAAHSQFEQAYQLVVAIAGE 488
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1565 hvtvaqlreeaerraqqqaeaerareeaERELERWQlKANEALRLRLQAEEVAQQKSLAQAdaekqkeeaerearrrgka 1644
Cdd:COG3096   489 ----------------------------LARSEAWD-VARELLREGPDQRHLAEQVQPLRM------------------- 520
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1645 eeqavRQRELaEQELEKQRQ----LAEGTAQQRLAAEQEliRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEA 1720
Cdd:COG3096   521 -----RLSEL-EQRLRQQQSaerlLADFCKRQGKNLDAE--ELEALHQELEALIESLSDSVSNAREQRMALRQEQEQLQS 592
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1721 ELAKVRAEMEVLLASKARAE----------EESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAA 1790
Cdd:COG3096   593 RIQSLMQRAPVWLAAQNALEqlseqsgeefTDSQDVTEYMQQLLEREREATVERDELGARKNALDEEIERLSQPGGSEDQ 672

                  ....*...
gi 254675251 1791 RQRAEAER 1798
Cdd:COG3096   673 RLNALAER 680
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
1963-2573 2.60e-09

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 63.97  E-value: 2.60e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1963 EEAARQRKVALEEVERLKAKVEEARRLRERAEqesaRQLQLAQEAaqKRLQAEEKAHAFVVQQREEELQQTLqqeqnmLD 2042
Cdd:COG1196   175 EEAERKLERTEENLERLEDLLEELEKQLEKLE----RQAEKAERY--QELKAELRELELALLLAKLKELRKE------LE 242
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2043 RLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAAL 2122
Cdd:COG1196   243 ELEEELSRLEEELEELQEELEEAEKEIEELKSELEELREELEELQEELLELKEEIEELEGEISLLRERLEELENELEELE 322
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2123 KQKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEET----DHQKSILDEELQRLKAEVTEAARQRSQVEEELFSV 2198
Cdd:COG1196   323 ERLEELKEKIEALKEELEERETLLEELEQLLAELEEAKEELeeklSALLEELEELFEALREELAELEAELAEIRNELEEL 402
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2199 RVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKmKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLK 2278
Cdd:COG1196   403 KREIESLEERLERLSERLEDLKEELKELEAELEELQTEL-EELNEELEELEEQLEELRDRLKELERELAELQEELQRLEK 481
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2279 EKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQqLVEETQGFQRTLE-----------------AERQRQL 2341
Cdd:COG1196   482 ELSSLEARLDRLEAEQRASQGVRAVLEALESGLPGVYGPVAE-LIKVKEKYETALEaalgnrlqavvveneevAKKAIEF 560
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2342 EMSAEAERLKL----RMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLReaI 2417
Cdd:COG1196   561 LKENKAGRATFlpldRIKPLRSLKSDAAPGFLGLASDLIDFDPKYEPAVRFVLGDTLVVDDLEQARRLARKLRIKYR--I 638
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2418 AELE---------------REKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLE 2482
Cdd:COG1196   639 VTLDgdlvepsgsitggsrNKRSSLAQKRELKELEEELAELEAQLEKLEEELKSLKNELRSLEDLLEELRRQLEELERQL 718
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2483 QLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEgvrrKQEELQHLEQQRQQQEKLLAEENQRLRER 2562
Cdd:COG1196   719 EELKRELAALEEELEQLQSRLEELEEELEELEEELEELQERLEELEE----ELESLEEALAKLKEEIEELEEKRQALQEE 794
                         650
                  ....*....|.
gi 254675251 2563 LQRLEEEHRAA 2573
Cdd:COG1196   795 LEELEEELEEA 805
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1618-1828 3.07e-09

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 62.27  E-value: 3.07e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1618 QQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQlaegtaqQRLAAEQELIRLRAETEQGEQQRQLL 1697
Cdd:COG3064    70 QQSSAKKGEQQRKKKEEQVAEELKPKQAAEQERLKQLEKERLKAQEQ-------QKQAEEAEKQAQLEQKQQEEQARKAA 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1698 EEELARLQHEATAATQkrqelEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGrfrelAEEAARLRALAEE 1777
Cdd:COG3064   143 AEQKKKAEAAKAKAAA-----EAAKLKAAAEAKKKAEEAAKAAEEAKAKAEAAAAKKKAEAE-----AKAAAEKAKAEAE 212
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 254675251 1778 AKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAEN 1828
Cdd:COG3064   213 AKAKAEKKAEAAAEEKAAAEKKKAAAKAKADKAAAAAKAAERKAAAAALDD 263
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
1335-1556 3.36e-09

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 62.13  E-value: 3.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1335 EKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEaavdaQQQKRSIQEELQhlRQSSEAEIQAKAQQVEAAERsrmr 1414
Cdd:PRK09510   69 QQQKSAKRAEEQRKKKEQQQAEELQQKQAAEQERLKQ-----LEKERLAAQEQK--KQAEEAAKQAALKQKQAEEA---- 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1415 ieeeirvvrlQLETTERQRGGAEGELQALRARAEEAEAQ-KRQAQEEAerlrrQVQDESQRKRQAEAELALRVKAEAEAA 1493
Cdd:PRK09510  138 ----------AAKAAAAAKAKAEAEAKRAAAAAKKAAAEaKKKAEAEA-----AKKAAAEAKKKAEAEAAAKAAAEAKKK 202
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251 1494 REKQRALQAldelrlqAEEAErrlRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQ 1556
Cdd:PRK09510  203 AEAEAKKKA-------AAEAK---KKAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKA 255
CH_FLNC_rpt2 cd21314
second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins; ...
127-229 3.57e-09

second calponin homology (CH) domain found in filamin-C (FLN-C) and similar proteins; Filamin-C (FLN-C), also called FLNc, ABP-280-like protein, ABP-L, actin-binding-like protein, filamin-2, or gamma-filamin, is a muscle-specific filamin that plays a central role in muscle cells, probably by functioning as a large actin-cross-linking protein. It may be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. FLN-C is critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. FLN-C contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409163  Cd Length: 115  Bit Score: 57.39  E-value: 3.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  127 TAKEKLLLWSQRMVEGyqgLRCDNFTTSWRDGRLFNAIIHRHKPMLI-DMNKVYRQTNLENLDQAFSVAERDLGVTRLLD 205
Cdd:cd21314    11 TPKQRLLGWIQNKVPQ---LPITNFNRDWQDGKALGALVDNCAPGLCpDWESWDPNQPVQNAREAMQQADDWLGVPQVIA 87
                          90       100
                  ....*....|....*....|....
gi 254675251  206 PEDVDVPQPDEKSIITYVSSLYDA 229
Cdd:cd21314    88 PEEIVDPNVDEHSVMTYLSQFPKA 111
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1691-1994 4.29e-09

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227278 [Multi-domain]  Cd Length: 420  Bit Score: 62.05  E-value: 4.29e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1691 EQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLlaskaraeEESRSTSEKSKQRLEAEagrfreLAEEAAR 1770
Cdd:COG4942    37 DKQLKQIQKEIAALEKKIREQQDQRAKLEKQLKSLETEIASL--------EAQLIETADDLKKLRKQ------IADLNAR 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1771 LRAL-AEEAKRQRQLAEEDAARQRAEAERVLTEKLAA--ISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEE 1847
Cdd:COG4942   103 LNALeVQEREQRRRLAEQLAALQRSGRNPPPALLVSPedAQRSVRLAIYYGALNPARAERIDALKATLKQLAAVRAEIAA 182
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1848 QAALHKADIEERLAQLRKASESELERQKGLvedtlrqrRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRSK 1927
Cdd:COG4942   183 EQAELTTLLSEQRAQQAKLAQLLEERKKTL--------AQLNSELSADQKKLEELRANESRLKNEIASAEAAAAKAREAA 254
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251 1928 EQAELEAARQRqlaaeeeqrrreaeervqrslAAEEEAARQRKVALEEVERLKAKVEEARRLRERAE 1994
Cdd:COG4942   255 AAAEAAAARAR---------------------AAEAKRTGETYKPTAPEKMLISSTGGFGALRGQLA 300
CH_AtFIM_like_rpt3 cd21299
third calponin homology (CH) domain found in the Arabidopsis thaliana fimbrin family; The ...
12-111 5.16e-09

third calponin homology (CH) domain found in the Arabidopsis thaliana fimbrin family; The Arabidopsis thaliana fimbrin (AtFIM) family includes Fimbrin-1, -2, -3, -4, and -5, which cross-link actin filaments (F-actin) in a calcium independent manner. They stabilize and prevent F-actin depolymerization mediated by profilin. They act as key regulators of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus. AtFIM5 is an actin bundling factor that is required for pollen germination and pollen tube growth. Members of this family contain four copies of the CH domain. This model corresponds to the third CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409148  Cd Length: 114  Bit Score: 56.74  E-value: 5.16e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   12 QKKTFTKWVNKhlIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKG-----RMRFHKLQNVQIALDYLRHRQVKLV 86
Cdd:cd21299     5 EERCFRLWINS--LGIDTYVNNVFEDVRDGWVLLEVLDKVSPGSVNWKHAnkppiKMPFKKVENCNQVVKIGKQLKFSLV 82
                          90       100
                  ....*....|....*....|....*
gi 254675251   87 NIRNDDIADGNPKLTLGLIWTIILH 111
Cdd:cd21299    83 NVAGNDIVQGNKKLILALLWQLMRY 107
CH_dFLNA-like_rpt2 cd21315
second calponin homology (CH) domain found in Drosophila melanogaster filamin-A (dFLNA) and ...
122-224 6.06e-09

second calponin homology (CH) domain found in Drosophila melanogaster filamin-A (dFLNA) and similar proteins; Drosophila melanogaster filamin-A (dFLNA or dFLN-A), also called actin-binding protein 280 (ABP-280) or filamin-1, is involved in germline ring canal formation. It may tether actin microfilaments within the ovarian ring canal to the cell membrane and contributes to actin microfilament organization. dFLNA contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409164  Cd Length: 118  Bit Score: 56.71  E-value: 6.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  122 QSEDMTAKEKLLLWSQRMVEGyqgLRCDNFTTSWRDGRLFNAIIHRHKPMLI-DMNKVYRQTNLENLDQAFSVAERDLGV 200
Cdd:cd21315    11 DGKGPTPKQRLLGWIQSKVPD---LPITNFTNDWNDGKAIGALVDALAPGLCpDWEDWDPKDAVKNAKEAMDLAEDWLDV 87
                          90       100
                  ....*....|....*....|....
gi 254675251  201 TRLLDPEDVDVPQPDEKSIITYVS 224
Cdd:cd21315    88 PQLIKPEEMVNPKVDELSMMTYLS 111
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
1307-1540 6.07e-09

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 61.08  E-value: 6.07e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1307 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKrsIQEE 1386
Cdd:pfam13868   36 AEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKQYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVER--IQEE 113
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1387 LQHLRQSSEAEIQAKAQQVEAAERSRMRI---------EEEIRVVRLQLETTERQRggAEGELQALRARAEEAEAQKRQA 1457
Cdd:pfam13868  114 DQAEAEEKLEKQRQLREEIDEFNEEQAKWkelekeeekEEDLRILEYLKEKAEREE--EREAERREIKEEKEREIARLRA 191
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1458 QEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQR 1537
Cdd:pfam13868  192 QQEKAQDEKAERDELRAKLYQEEQERKWRQKEREEAEKKARQRQELQQAREEQIELKERRLAEEAEREEEEFERMLRKQA 271

                   ...
gi 254675251  1538 SAE 1540
Cdd:pfam13868  272 EDE 274
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
1300-1542 6.13e-09

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 61.08  E-value: 6.13e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1300 KFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQ 1379
Cdd:pfam13868   88 KRQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAKWKELEKEEEKEEDLRILEYLKEKAER 167
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1380 KRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEeirvVRLQLETTERQRGGAEGELQALRARAEEaEAQKRQAQE 1459
Cdd:pfam13868  168 EEEREAERREIKEEKEREIARLRAQQEKAQDEKAERDE----LRAKLYQEEQERKWRQKEREEAEKKARQ-RQELQQARE 242
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1460 EAERLRRQVQDESQRKRQAEAELALRVKAEAE------AAREKQRALQALDELRLQAEEAER-RLRQAEAERARQVQVAL 1532
Cdd:pfam13868  243 EQIELKERRLAEEAEREEEEFERMLRKQAEDEeieqeeAEKRREKRLEHRRELEKQIEERERqRAAEREEELEEGERLRE 322
                          250
                   ....*....|
gi 254675251  1533 ETAQRSAEVE 1542
Cdd:pfam13868  323 EEAERRERIE 332
SPEC cd00176
Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members ...
1067-1257 7.15e-09

Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; the repeats are independent folding units; tandem repeats are found in differing numbers and arrange in an antiparallel manner to form dimers; the repeats are defined by a characteristic tryptophan (W) residue in helix A and a leucine (L) at the carboxyl end of helix C and separated by a linker of 5 residues; two copies of the repeat are present here


Pssm-ID: 238103 [Multi-domain]  Cd Length: 213  Bit Score: 59.00  E-value: 7.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1067 EEVLKTHEEQLKEAQaVPATLQELEATKASLKKLRAQAEAQQPVFNTLrdelrgaQEVGERLQQRHGERDVEVerwRERV 1146
Cdd:cd00176    13 EAWLSEKEELLSSTD-YGDDLESVEALLKKHEALEAELAAHEERVEAL-------NELGEQLIEEGHPDAEEI---QERL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1147 TQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADpLSAWLQDAKRRQEQIQavPIANCQAAREQLRQEKALLEEIERH 1226
Cdd:cd00176    82 EELNQRWEELRELAEERRQRLEEALDLQQFFRDADD-LEQWLEEKEAALASED--LGKDLESVEELLKKHKELEEELEAH 158
                         170       180       190
                  ....*....|....*....|....*....|.
gi 254675251 1227 GEKVEECQKFAKQYINAIKDYELQLITYKAQ 1257
Cdd:cd00176   159 EPRLKSLNELAEELLEEGHPDADEEIEEKLE 189
CH_ASPM_rpt2 cd21224
second calponin homology (CH) domain found in abnormal spindle-like microcephaly-associated ...
131-226 8.03e-09

second calponin homology (CH) domain found in abnormal spindle-like microcephaly-associated protein (ASPM) and similar proteins; ASPM, also called abnormal spindle protein homolog, or Asp homolog, is involved in mitotic spindle regulation and coordination of mitotic processes. It may also have a preferential role in regulating neurogenesis. Members of this family contain two copies of CH domain in the middle region. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409073 [Multi-domain]  Cd Length: 138  Bit Score: 56.93  E-value: 8.03e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  131 KLLL-WSQrMVEGYQGLRCDNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNL-----------------------EN 186
Cdd:cd21224     3 SLLLkWCQ-AVCAHYGVKVENFTVSFADGRALCYLIHHYLPSLLPLDAIRQPTTQtvdraqdeaedfwvaefspstgdSG 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 254675251  187 LDQAFSVAER-----------DLG-VTRLLDPEDVDVPQPDEKSIITYVSSL 226
Cdd:cd21224    82 LSSELLANEKrnfklvqqavaELGgVPALLRASDMSNTIPDEKVVILFLSYL 133
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1012-1558 9.23e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.00  E-value: 9.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1012 AEKVLALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKTHEEQLKEaqaVPATLQELE 1091
Cdd:PRK03918  203 EEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEE---LKKEIEELE 279
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1092 ATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLqqrhgerdveverwrERVTQLLERWQAVLAQTDVRQRELEQLG 1171
Cdd:PRK03918  280 EKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRL---------------SRLEEEINGIEERIKELEEKEERLEELK 344
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1172 RQLRYYRESADPLSAW---LQDAKRRQEQIqavpiancqaarEQLRQEKALL--EEIERHGEKVEECQKFAKQYINAIKD 1246
Cdd:PRK03918  345 KKLKELEKRLEELEERhelYEEAKAKKEEL------------ERLKKRLTGLtpEKLEKELEELEKAKEEIEEEISKITA 412
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1247 YELQLITYKAQLEPVASPAKKPKVQS---GSESVIQEYVDLRTRYSElttltsqYIKFISETLRRMEEEERlaeqqraEE 1323
Cdd:PRK03918  413 RIGELKKEIKELKKAIEELKKAKGKCpvcGRELTEEHRKELLEEYTA-------ELKRIEKELKEIEEKER-------KL 478
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1324 RERLAEVEAALEKQRQLAEAHAQAKAQAELEaQELQRRMQEEVARREEAAvdaqqqkRSIQEELQHLrqssEAEIQAKAQ 1403
Cdd:PRK03918  479 RKELRELEKVLKKESELIKLKELAEQLKELE-EKLKKYNLEELEKKAEEY-------EKLKEKLIKL----KGEIKSLKK 546
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1404 QVEAAERsrmrIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELA 1483
Cdd:PRK03918  547 ELEKLEE----LKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKELK 622
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 1484 lRVKAEAEAAREK-QRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLE 1558
Cdd:PRK03918  623 -KLEEELDKAFEElAETEKRLEELRKELEELEKKYSEEEYEELREEYLELSRELAGLRAELEELEKRREEIKKTLE 697
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
1307-1514 9.23e-09

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 60.98  E-value: 9.23e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1307 RRMEEEERLAEQQRAEERErlaEVEAALEKQRQLaeahaqakAQAELEAQElQRRMQEEVARREeaavdAQQQKrsiQEE 1386
Cdd:PRK09510   76 RAEEQRKKKEQQQAEELQQ---KQAAEQERLKQL--------EKERLAAQE-QKKQAEEAAKQA-----ALKQK---QAE 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1387 LQHLRQSSEAEIQAKAQQVEAAERSRmRIEEEIRvVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERlrr 1466
Cdd:PRK09510  136 EAAAKAAAAAKAKAEAEAKRAAAAAK-KAAAEAK-KKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKK--- 210
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 254675251 1467 qVQDESQRKRQAEAELAL-RVKAEAEAAREKQRALQALDELRLQAEEAE 1514
Cdd:PRK09510  211 -AAAEAKKKAAAEAKAAAaKAAAEAKAAAEKAAAAKAAEKAAAAKAAAE 258
YhaN COG4717
Uncharacterized protein YhaN, contains AAA domain [Function unknown];
1075-1794 1.12e-08

Uncharacterized protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 227061 [Multi-domain]  Cd Length: 984  Bit Score: 61.78  E-value: 1.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1075 EQLKEAQAVPATLQELEATKASLKKLRAQAEAQQPVFNTLRDELRgaqevgeRLQQRHGERDVEVERWRervtqLLERWQ 1154
Cdd:COG4717   185 QLLEKLKQERNEIDEAEKEYATYHKLLESRRAEHARLAELRSELR-------ADRDHIRALRDAVELWP-----RLQEWK 252
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1155 AVLAQTDVRQRELEQLGR----QLRYYRESADPLSAWLQDAKRRQEQIQAVPIANCQAAREQLRQEKALLEEIERHGEKV 1230
Cdd:COG4717   253 QLEQELTRRREELATFPRdgvlRLEKREAHLQKTEAEIDALLVRLAELKDLASQLIPAKEAVLQALVRLHQQLSEIKASA 332
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1231 EECQKFAKQYINAIKDYElqlitykAQLEPVASPAKKPKVQSGSEsvIQEYVDLRTrysELTTLTSQYIKFISE-TLRRM 1309
Cdd:COG4717   333 FELTETLAGIEADLRDKE-------EAAGNGFEAERVHDLRSLEC--MLRYQSSQR---ELKQTEAAYCKRLDEkRLFED 400
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1310 EEEERLAEQQRAEERERLAEVEAALEKQ---RQLAEAHAQAKAQAELEAQELQRRM---QEEVARREEAAVDAQQQKRSI 1383
Cdd:COG4717   401 EAEEEARQRLADDEEEVRAGDEAREEKIaanSQVIDKEEVCNLYDRRDTAWQKQRFlreKQTAFERQKTEHTKIIALRLA 480
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1384 QEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRlqletterqrggaegelqALRARAEEAEAQKRQAQEEAER 1463
Cdd:COG4717   481 GMLLVALSRLLTSLIFQIIFAVAQIVFLSAEIKSSSRAVR------------------EEKAAVTDIPEELARLLITDEL 542
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1464 LRRQV-QDESQRKRQAEAEL--ALRVKAEAEAAREKQ--RALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQrs 1538
Cdd:COG4717   543 PELAVdLLVQSRIRQHWQQLrkALDQLEAAYEALEGRfaAAEAAMAEWQSEWEEALDELGLSRELSPEQQLDILSTMK-- 620
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1539 aevELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ 1618
Cdd:COG4717   621 ---DLKKLMQKKAELTHQVARLREEQAAFEERVEGLLAVLEAQFIDLSTLFCVQRLRVAAELQKEEARLALEGNIERTKE 697
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1619 QKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQElirlRAETEQGEQQRQLLE 1698
Cdd:COG4717   698 LNDELRAELELHRKEILDLFDCGTADTEDAFREAAREEQQLTQRESRLESLEAQLEGVAAE----AYELSASLDQRELKE 773
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1699 EELARLQHEATAATQKRQELEAELAKVRAEMEVLlaskaraeeESRSTSEKSKQRLEAEAGRFRELAEEAARLRA---LA 1775
Cdd:COG4717   774 EELALLEEAIDALDEEVEELHAQVAALSRQIAQL---------EGGGTVAELRQRRESLKEDLEEKARKWASLRLavqVL 844
                         730
                  ....*....|....*....
gi 254675251 1776 EEAKRQRQLAEEDAARQRA 1794
Cdd:COG4717   845 EEALRLFKERRLPAVIQEA 863
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1126-1433 1.43e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 61.29  E-value: 1.43e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1126 ERLQQRHGERDVEVERWR-----ERVTQL-LERWQAVLAQTD----VRQRELEQLGrqlryyresadplsawLQDAKRRQ 1195
Cdd:pfam17380  299 ERLRQEKEEKAREVERRRkleeaEKARQAeMDRQAAIYAEQErmamERERELERIR----------------QEERKREL 362
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1196 EQIQAVPIAncqAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVaspakKPKVQSGSE 1275
Cdd:pfam17380  363 ERIRQEEIA---MEISRMRELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQI-----RAEQEEARQ 434
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1276 SVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEaalEKQRQLAEAHAQAKAQAELEA 1355
Cdd:pfam17380  435 REVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAE---EQRRKILEKELEERKQAMIEE 511
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251  1356 QELQRRMQEEVARREEAAvdAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAA-ERSRMRIEEEIRVVRLQLETTERQR 1433
Cdd:pfam17380  512 ERKRKLLEKEMEERQKAI--YEEERRREAEEERRKQQEMEERRRIQEQMRKATeERSRLEAMEREREMMRQIVESEKAR 588
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1798-2536 1.47e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.24  E-value: 1.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1798 RVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQaalhKADIEERLAQLRKASESELERQKGL 1877
Cdd:TIGR02169  156 RKIIDEIAGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQQLERLRRE----REKAERYQALLKEKREYEGYELLKE 231
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1878 VEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAED-TMRSKEQAELEAARQRQLAAEEEQRRREAEERVQ 1956
Cdd:TIGR02169  232 KEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEElNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIA 311
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1957 RSLAAEEEAARQRKVALEEVERLKAKVEEarrLRERAEQESARQLQLAQEAAQK---------RLQAEEKAHAFVVqqre 2027
Cdd:TIGR02169  312 EKERELEDAEERLAKLEAEIDKLLAEIEE---LEREIEEERKRRDKLTEEYAELkeeledlraELEEVDKEFAETR---- 384
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2028 eelqqtlqqeqnmlDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAaeklrkea 2107
Cdd:TIGR02169  385 --------------DELKDYREKLEKLKREINELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEE-------- 442
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2108 eqeaarraqaeqaalkqKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAE---VTEA 2184
Cdd:TIGR02169  443 -----------------KEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELAEAEAQaraSEER 505
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2185 ARQRSQVEEELFS----VRVQMEELGKLKAR------IEAENR--ALILRDKDNTQR---FLEEEA---------EKMKQ 2240
Cdd:TIGR02169  506 VRGGRAVEEVLKAsiqgVHGTVAQLGSVGERyataieVAAGNRlnNVVVEDDAVAKEaieLLKRRKagratflplNKMRD 585
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2241 VAEEAARLSVAA-------------QEAARLRQ-----LAEEDLAQQRALAEKM--------LKEKMQAVQEATRLKAEA 2294
Cdd:TIGR02169  586 ERRDLSILSEDGvigfavdlvefdpKYEPAFKYvfgdtLVVEDIEAARRLMGKYrmvtlegeLFEKSGAMTGGSRAPRGG 665
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2295 ELLQQQKElaqEQARRLQEDKEQMAQQLveetQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQ 2374
Cdd:TIGR02169  666 ILFSRSEP---AELQRLRERLEGLKREL----SSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKER 738
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2375 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELER-----------------EKEKLKQEAKLLQLK 2437
Cdd:TIGR02169  739 LEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEArlshsripeiqaelsklEEEVSRIEARLREIE 818
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2438 SEEMQTVQQEQILQ-ETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLfQDEVAKAKQLREEQQRQQQQMEQEKQELMAS 2516
Cdd:TIGR02169  819 QKLNRLTLEKEYLEkEIQELQEQRIDLKEQIKSIEKEIENLNGKKEEL-EEELEELEAALRDLESRLGDLKKERDELEAQ 897
                          810       820
                   ....*....|....*....|
gi 254675251  2517 MEEARRRQREAEEGVRRKQE 2536
Cdd:TIGR02169  898 LRELERKIEELEAQIEKKRK 917
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
2129-2590 1.62e-08

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 61.14  E-value: 1.62e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2129 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKaevtEAARQRSQVEEELFSVRVQMEELGKL 2208
Cdd:TIGR00618  200 TLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQKR----EAQEEQLKKQQLLKQLRARIEELRAQ 275
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2209 KARIEAENRALILRDKDNTqrfLEEEAEKMKQVAEEAARLSVAAQEAARLR----------QLAEEDLAQQRALAEKMLK 2278
Cdd:TIGR00618  276 EAVLEETQERINRARKAAP---LAAHIKAVTQIEQQAQRIHTELQSKMRSRakllmkraahVKQQSSIEEQRRLLQTLHS 352
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2279 EKMQAVQEATRLKAEAELLQQQKELAQeQARRLQEDKEQMAQQLVEETQgfqrtlEAERQRQLEMSAEAERLKLRMAEMS 2358
Cdd:TIGR00618  353 QEIHIRDAHEVATSIREISCQQHTLTQ-HIHTLQQQKTTLTQKLQSLCK------ELDILQREQATIDTRTSAFRDLQGQ 425
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2359 RAQARAEEDAQRFRKQAEEigekLHRTELATQEKVTLVQTLEIQrQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKS 2438
Cdd:TIGR00618  426 LAHAKKQQELQQRYAELCA----AAITCTAQCEKLEKIHLQESA-QSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQ 500
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2439 EEMQTVQqEQILQETQALQKSFLSEKDS-----LLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQEL 2513
Cdd:TIGR00618  501 EEPCPLC-GSCIHPNPARQDIDNPGPLTrrmqrGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFSILTQCD 579
                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251  2514 MASMEEArrrqreaeEGVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSEIATTQAASTKAL 2590
Cdd:TIGR00618  580 NRSKEDI--------PNLQNITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTAL 648
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
1355-1562 1.71e-08

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 60.42  E-value: 1.71e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1355 AQELQRRMQEEVARREEAAvdAQQQKRSIQEELQHLRQSSEA---EIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTER 1431
Cdd:COG4372    74 FQLDDIRPQLRALRTELGT--AQGEKRAAETEREAARSELQKarqEREAVRQELAAARQNLAKAQQELARLTKQAQDLQT 151
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1432 QRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAElalrvkaeAEAAREKQRALQALDElRLQAE 1511
Cdd:COG4372   152 RLKTLAEQRRQLEAQAQSLQASQKQLQASATQLKSQVLDLKLRSAQIEQE--------AQNLATRANAAQARTE-ELARR 222
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675251 1512 EAERRLRQAEA-ERARQV-QVALETAQRSAEVELQSKRASFAEK--------TAQLERTLQ 1562
Cdd:COG4372   223 AAAAQQTAQAIqQRDAQIsQKAQQIAARAEQIRERERQLQRLETaqarleqeVAQLEAYYQ 283
CH_FLNB_rpt2 cd21313
second calponin homology (CH) domain found in filamin-B (FLN-B) and similar proteins; ...
122-229 1.84e-08

second calponin homology (CH) domain found in filamin-B (FLN-B) and similar proteins; Filamin-B (FLN-B) is also called ABP-278, ABP-280 homolog, actin-binding-like protein, beta-filamin, filamin homolog 1 (Fh1), filamin-3, thyroid autoantigen, truncated actin-binding protein, or truncated ABP. It connects cell membrane constituents to the actin cytoskeleton. It may promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. It anchors various transmembrane proteins to the actin cytoskeleton. FLN-B contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409162  Cd Length: 110  Bit Score: 55.10  E-value: 1.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  122 QSEDMTAKEKLLLWSQRMVEGyqgLRCDNFTTSWRDGRLFNAIIHRHKPMLI-DMNKVYRQTNLENLDQAFSVAERDLGV 200
Cdd:cd21313     3 DAKKQTPKQRLLGWIQNKIPY---LPITNFNQNWQDGKALGALVDSCAPGLCpDWESWDPQKPVDNAREAMQQADDWLGV 79
                          90       100
                  ....*....|....*....|....*....
gi 254675251  201 TRLLDPEDVDVPQPDEKSIITYVSSLYDA 229
Cdd:cd21313    80 PQVITPEEIIHPDVDEHSVMTYLSQFPKA 108
CH_NAV3 cd21286
calponin homology (CH) domain found in neuron navigator 3; Neuron navigator 3 (NAV3), also ...
14-108 2.67e-08

calponin homology (CH) domain found in neuron navigator 3; Neuron navigator 3 (NAV3), also called pore membrane and/or filament-interacting-like protein 1 (POMFIL1), Steerin-3 (STEERIN3), or Unc-53 homolog 3 (unc53H3), may regulate IL2 production by T-cells. It may be involved in neuron regeneration. NAV3 contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409135  Cd Length: 105  Bit Score: 54.65  E-value: 2.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   14 KTFTKWVNKHLIKA--QRHISDLYEDLRDGHNLISLLEVLSGD------SLPREKGRMrfhkLQNVQIALDYLRHRQVKL 85
Cdd:cd21286     3 KIYTDWANHYLAKSghKRLIKDLQQDIADGVLLAEIIQIIANEkvedinGCPRSQSQM----IENVDVCLSFLAARGVNV 78
                          90       100
                  ....*....|....*....|...
gi 254675251   86 VNIRNDDIADGNPKLTLGLIWTI 108
Cdd:cd21286    79 QGLSAEEIRNGNLKAILGLFFSL 101
YhaN COG4717
Uncharacterized protein YhaN, contains AAA domain [Function unknown];
1314-1938 3.00e-08

Uncharacterized protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 227061 [Multi-domain]  Cd Length: 984  Bit Score: 60.24  E-value: 3.00e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1314 RLAEQQRAEERERLAEVEAALEKQ---RQLAEAHAQAKAQAELEAQE--LQRRMQEEVARREEAAVDAQQQKRSIQEELQ 1388
Cdd:COG4717   234 HIRALRDAVELWPRLQEWKQLEQEltrRREELATFPRDGVLRLEKREahLQKTEAEIDALLVRLAELKDLASQLIPAKEA 313
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1389 HL-----RQSSEAEIQAKAQ---QVEAAERSRMRIEEEI--------RVVRLQLETTERQRGGAEGELQALRARAEEAEA 1452
Cdd:COG4717   314 VLqalvrLHQQLSEIKASAFeltETLAGIEADLRDKEEAagngfeaeRVHDLRSLECMLRYQSSQRELKQTEAAYCKRLD 393
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1453 QKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVAL 1532
Cdd:COG4717   394 EKRLFEDEAEEEARQRLADDEEEVRAGDEAREEKIAANSQVIDKEEVCNLYDRRDTAWQKQRFLREKQTAFERQKTEHTK 473
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1533 ETAQRSAEVELQSKRASFAEKTAQL---ERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRL 1609
Cdd:COG4717   474 IIALRLAGMLLVALSRLLTSLIFQIifaVAQIVFLSAEIKSSSRAVREEKAAVTDIPEELARLLITDELPELAVDLLVQS 553
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1610 RLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEkqRQLAEGTAQQRLAAEQELIRLRAETEQ 1689
Cdd:COG4717   554 RIRQHWQQLRKALDQLEAAYEALEGRFAAAEAAMAEWQSEWEEALDELGLS--RELSPEQQLDILSTMKDLKKLMQKKAE 631
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1690 GEQQRQLLEEELARLQHEATAATqkrQELEAELAKVRAEMEV--LLASKARAEEESRSTSEKSKQRLEAEAGRFR-ELAE 1766
Cdd:COG4717   632 LTHQVARLREEQAAFEERVEGLL---AVLEAQFIDLSTLFCVqrLRVAAELQKEEARLALEGNIERTKELNDELRaELEL 708
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1767 EAARLRALAEEAKrqrqLAEEDAARQRAEAERVLTEKLAAISEATRlKTEAEIALKEKEAENERLRRLAEDEAfqrRRLE 1846
Cdd:COG4717   709 HRKEILDLFDCGT----ADTEDAFREAAREEQQLTQRESRLESLEA-QLEGVAAEAYELSASLDQRELKEEEL---ALLE 780
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1847 EQAALHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQveeeimALKVSFEKAAAGKAELELelgrIRSNAEDTMRS 1926
Cdd:COG4717   781 EAIDALDEEVEELHAQVAALSRQIAQLEGGGTVAELRQRRE------SLKEDLEEKARKWASLRL----AVQVLEEALRL 850
                         650
                  ....*....|..
gi 254675251 1927 KEQAELEAARQR 1938
Cdd:COG4717   851 FKERRLPAVIQE 862
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
1647-1863 3.17e-08

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 59.65  E-value: 3.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1647 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVR 1726
Cdd:COG4372    71 SGVFQLDDIRPQLRALRTELGTAQGEKRAAETEREAARSELQKARQEREAVRQELAAARQNLAKAQQELARLTKQAQDLQ 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1727 AEMEVLLASKARAEEESRSTSEKSKQrLEAEAG----RFRELAEEAARLRALAEEAKRQRQLAEEDAAR-QRAEAERVLT 1801
Cdd:COG4372   151 TRLKTLAEQRRQLEAQAQSLQASQKQ-LQASATqlksQVLDLKLRSAQIEQEAQNLATRANAAQARTEElARRAAAAQQT 229
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251 1802 EKLAAISEATRLKTEAEIALKEKE--AENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQL 1863
Cdd:COG4372   230 AQAIQQRDAQISQKAQQIAARAEQirERERQLQRLETAQARLEQEVAQLEAYYQAYVRLRQQAA 293
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
2162-2376 3.20e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227278 [Multi-domain]  Cd Length: 420  Bit Score: 59.35  E-value: 3.20e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2162 ETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMeelgklkARIEAENRALILRDKDNTQRFLEEEAEKMK-Q 2240
Cdd:COG4942    35 ADDKQLKQIQKEIAALEKKIREQQDQRAKLEKQLKSLETEI-------ASLEAQLIETADDLKKLRKQIADLNARLNAlE 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2241 VAEEAARLSVAAQEAARLRQLAEEDLA----QQRALAEKMLKEKMQAVQEAtRLKAEAELLQQQKELAQEQARRLQEDKE 2316
Cdd:COG4942   108 VQEREQRRRLAEQLAALQRSGRNPPPAllvsPEDAQRSVRLAIYYGALNPA-RAERIDALKATLKQLAAVRAEIAAEQAE 186
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251 2317 QMAQ--QLVEETQGFQRTLEA----ERQRQLEMSAEAER---LKLRMAEMSRAQARAEEDAQRFRKQAE 2376
Cdd:COG4942   187 LTTLlsEQRAQQAKLAQLLEErkktLAQLNSELSADQKKleeLRANESRLKNEIASAEAAAAKAREAAA 255
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1297-2014 3.56e-08

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 435022 [Multi-domain]  Cd Length: 1112  Bit Score: 60.12  E-value: 3.56e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1297 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAV-- 1374
Cdd:pfam15921   82 EYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDLQTKLQEMQMERDAMADIRRRESQSQEDLRNQLQNTVHELEAAKClk 161
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1375 -DAQQQKRSIQEELQHLRQSSEAEIQA-KAQQVEAAERSRMRIEEEIRVVRLQLetteRQRGGA--------EGELQALR 1444
Cdd:pfam15921  162 eDMLNDSNTQIEQLRKMMLSHEGVLQEiRSILVDFEEASGKKIYEHDSMSTIHF----RSLGSAiskilrelDTEISYLK 237
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1445 AR----AEEAEAQKRQAQEEAERLRRQVQDE-SQRKRQAEAELAlRVKAEAEAAREKQRALQAldelrlQAEEAERRLRQ 1519
Cdd:pfam15921  238 GRifpvEDQLEALKSESQNKIELLLQQHQDRiEQLISEHEVEIT-GLTEKASSARSQANSIQS------QLEIIQEQARN 310
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1520 AEAERARQVQvALETAQRSAEVELQSKRASFAEKTAQLERTL------------------QEEHVTVAQLREEAERRAQQ 1581
Cdd:pfam15921  311 QNSMYMRQLS-DLESTVSQLRSELREAKRMYEDKIEELEKQLvlanseltearterdqfsQESGNLDDQLQKLLADLHKR 389
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1582 QAEAERAREEAERELERWQLKANEALRLRLQAE----EVAQQKSLAQA-DAEKQKEEAEREARRRGKAEEQAVRQRELAE 1656
Cdd:pfam15921  390 EKELSLEKEQNKRLWDRDTGNSITIDHLRRELDdrnmEVQRLEALLKAmKSECQGQMERQMAAIQGKNESLEKVSSLTAQ 469
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1657 QELEKQ--RQLAEGTAQQRL---AAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAE---LAKVRAE 1728
Cdd:pfam15921  470 LESTKEmlRKVVEELTAKKMtleSSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEgdhLRNVQTE 549
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1729 MEVL---LASKARAEEESRSTSEK-----------------SKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEED 1788
Cdd:pfam15921  550 CEALklqMAEKDKVIEILRQQIENmtqlvgqhgrtagamqvEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEARVSD 629
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1789 AARQRAEAERVLTEKLAAISEatrLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLrKASE 1868
Cdd:pfam15921  630 LELEKVKLVNAGSERLRAVKD---IKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQL-KSAQ 705
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1869 SELERQKglveDTLRQRRQVEEEIMALKVSFEKA-AAGKAELELELGRIRSNAED-TMRSKEQAELEAARQRQLAAEEEQ 1946
Cdd:pfam15921  706 SELEQTR----NTLKSMEGSDGHAMKVAMGMQKQiTAKRGQIDALQSKIQFLEEAmTNANKEKHFLKEEKNKLSQELSTV 781
                          730       740       750       760       770       780       790
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1947 RRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVE--EARRLRERAEQESARqLQLAQEAAQKRLQA 2014
Cdd:pfam15921  782 ATEKNKMAGELEVLRSQERRLKEKVANMEVALDKASLQfaECQDIIQRQEQESVR-LKLQHTLDVKELQG 850
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1741-2024 3.69e-08

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 59.75  E-value: 3.69e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1741 EESRSTSEKSKQ----RLEAEagRFRELAEEAARlralaeEAKRQRQLAEEDAARQrAEAERvlteKLAAISEATRLKTE 1816
Cdd:pfam17380  279 QHQKAVSERQQQekfeKMEQE--RLRQEKEEKAR------EVERRRKLEEAEKARQ-AEMDR----QAAIYAEQERMAME 345
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1817 AE-----IALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQ----LRKASESELERQKGLVEDT--LRQR 1885
Cdd:pfam17380  346 RErelerIRQEERKRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQeleaARKVKILEEERQRKIQQQKveMEQI 425
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1886 RQVEEEIMALKV---------SFEKAAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQRQLAAEEEQRRREAEERVQ 1956
Cdd:pfam17380  426 RAEQEEARQREVrrleeerarEMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELEERK 505
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251  1957 RSLAAEEeaaRQRKVALEEVE-RLKAKVEEARR------LRERAEQESARQLQLAQEAA---QKRLQAEEKAHAFVVQ 2024
Cdd:pfam17380  506 QAMIEEE---RKRKLLEKEMEeRQKAIYEEERRreaeeeRRKQQEMEERRRIQEQMRKAteeRSRLEAMEREREMMRQ 580
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
1304-1526 4.36e-08

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 58.70  E-value: 4.36e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1304 ETLRRMEEEERLAEQQRAEERERLAEVE--AALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQkr 1381
Cdd:TIGR02794   68 ERQKKLEQQAEEAEKQRAAEQARQKELEqrAAAEKAAKQAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAERKAK-- 145
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1382 siqEELQHlrqssEAEIQAKAQQVEAAERSRmrieeeirvvrlqletterqrggAEGELQALRARAEEAEAQKRQAQEE- 1460
Cdd:TIGR02794  146 ---EEAAK-----QAEEEAKAKAAAEAKKKA-----------------------EEAKKKAEAEAKAKAEAEAKAKAEEa 194
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251  1461 ---AERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERAR 1526
Cdd:TIGR02794  195 kakAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAELGDIFGLASGSNAEKQGGARGAAAGSEVDK 263
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
1396-1625 4.47e-08

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 59.27  E-value: 4.47e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1396 AEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1475
Cdd:COG4372    81 PQLRALRTELGTAQGEKRAAETEREAARSELQKARQEREAVRQELAAARQNLAKAQQELARLTKQAQDLQTRLKTLAEQR 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1476 RQAEaelalrvkAEAEAAREKQRALQALDElRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRAS---FAE 1552
Cdd:COG4372   161 RQLE--------AQAQSLQASQKQLQASAT-QLKSQVLDLKLRSAQIEQEAQNLATRANAAQARTEELARRAAAaqqTAQ 231
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251 1553 KTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1625
Cdd:COG4372   232 AIQQRDAQISQKAQQIAARAEQIRERERQLQRLETAQARLEQEVAQLEAYYQAYVRLRQQAAATQRGQVLAGA 304
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1422-1692 5.84e-08

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 225177 [Multi-domain]  Cd Length: 548  Bit Score: 59.08  E-value: 5.84e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1422 VRLQLETTERQR-GGAEGELQALRARAE-EAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRA 1499
Cdd:COG2268   213 RRRIAQVLQDAEiAENEAEKETEIAIAEaNRDAKLVELEVEQQPAGKTAEQTREVKIILAETEAEVAAWKAETRREAEQA 292
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1500 -LQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKtaqlERTLQEEHVTVAQLREEAERR 1578
Cdd:COG2268   293 eILAEQAIQEEKAQAEQEVQHAKALEAREMRVGLIERQKETELEPQERSYFINAA----QRQAQEEAKAAANIAEAIGAQ 368
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1579 AQQQAEAErareeaerelERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAeqE 1658
Cdd:COG2268   369 AEAAVETA----------RETEEAERAEQAALVAAAEAAEQEQVEIAVRAEAAKAEAEAQAAEIKAEAEAIREKGKA--E 436
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 254675251 1659 LEKQRQLAEGTAQQRLAAEQELI--RLRAETEQGEQ 1692
Cdd:COG2268   437 AEAKRALAEAIQVLGDAAAAELFkaLVQALPEVAEE 472
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1669-1885 6.36e-08

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227278 [Multi-domain]  Cd Length: 420  Bit Score: 58.58  E-value: 6.36e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1669 TAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS--- 1745
Cdd:COG4942    36 DDKQLKQIQKEIAALEKKIREQQDQRAKLEKQLKSLETEIASLEAQLIETADDLKKLRKQIADLNARLNALEVQEREqrr 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1746 ---------------------TSEKSKQRLEAEAGRFRELAEEaaRLRALAEEAKRQRQLA--EEDAARQRAEAERVLTE 1802
Cdd:COG4942   116 rlaeqlaalqrsgrnpppallVSPEDAQRSVRLAIYYGALNPA--RAERIDALKATLKQLAavRAEIAAEQAELTTLLSE 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1803 KLAAISEATRL-----KTEAEIAlKEKEAENERLRRLAEDEAFQRR---RLEEQAA--LHKADIEERLAQLRKASESELE 1872
Cdd:COG4942   194 QRAQQAKLAQLleerkKTLAQLN-SELSADQKKLEELRANESRLKNeiaSAEAAAAkaREAAAAAEAAAARARAAEAKRT 272
                         250
                  ....*....|...
gi 254675251 1873 RQKGLVEDTLRQR 1885
Cdd:COG4942   273 GETYKPTAPEKML 285
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
1735-2018 6.38e-08

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 59.19  E-value: 6.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1735 SKARAEEESRSTSEKSKQRLEAEAGRF-RELAEEAARlralAEEAKRQRQLAEEDAarqRAEAERVLTEKLAAISEATRL 1813
Cdd:PRK05035  436 AEIRAIEQEKKKAEEAKARFEARQARLeREKAAREAR----HKKAAEARAAKDKDA---VAAALARVKAKKAAATQPIVI 508
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1814 KTEAEIALKEKEAEnERLRRLAEDEAFQRRRLEEQAALHKADIEERL--AQLRKASESELERQKGLVEDTlrQRRQVEEE 1891
Cdd:PRK05035  509 KAGARPDNSAVIAA-REARKAQARARQAEKQAAAAADPKKAAVAAAIarAKAKKAAQQAANAEAEEEVDP--KKAAVAAA 585
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1892 ImalkvsfEKAAAGKAELelelgrirsnAEDTMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKV 1971
Cdd:PRK05035  586 I-------ARAKAKKAAQ----------QAASAEPEEQVAEVDPKKAAVAAAIARAKAKKAEQQANAEPEEPVDPRKAAV 648
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 254675251 1972 ALeEVERLKAKVEEARRLRERAEQESARQLQlAQEAAQKRLQAEEKA 2018
Cdd:PRK05035  649 AA-AIARAKARKAAQQQANAEPEEAEDPKKA-AVAAAIARAKAKKAA 693
mukB PRK04863
chromosome partition protein MukB;
982-1566 6.57e-08

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 59.20  E-value: 6.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  982 RECAQRIAEQQKAQaeveglgkgvaRLSAEAEKVLALPEPSPA-APTLRSELELTLGKL-EQVRSLSAIYLE-------- 1051
Cdd:PRK04863  523 SELEQRLRQQQRAE-----------RLLAEFCKRLGKNLDDEDeLEQLQEELEARLESLsESVSEARERRMAlrqqleql 591
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1052 -----KLKTISLVIRSTQGAEEVLKTH-EEQLKEAQAVPATLQELeatkasLKKLRAQAEAqqpvfntlRDELRGAQEV- 1124
Cdd:PRK04863  592 qariqRLAARAPAWLAAQDALARLREQsGEEFEDSQDVTEYMQQL------LERERELTVE--------RDELAARKQAl 657
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1125 ---GERLQQRHGERDveverwrERVTQLLERWQAVLAQTDVRQRELEQLGrqlrYYresadplSAWLQDAKrrqeqiQAV 1201
Cdd:PRK04863  658 deeIERLSQPGGSED-------PRLNALAERFGGVLLSEIYDDVSLEDAP----YF-------SALYGPAR------HAI 713
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1202 PIANCQAAREQLRQEKALLEEI-------ERHGEKVEECQKFAKQYINAIKDYELQLITYKAqlEPVASPAKKPK----V 1270
Cdd:PRK04863  714 VVPDLSDAAEQLAGLEDCPEDLyliegdpDSFDDSVFSVEELEKAVVVKIADRQWRYSRFPE--VPLFGRAAREKrieqL 791
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1271 QSGSESVIQEYVDLRTRYSELTTLTSQYIKFISETLRRMEEEErlAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ 1350
Cdd:PRK04863  792 RAEREELAERYATLSFDVQKLQRLHQAFSRFIGSHLAVAFEAD--PEAELRQLNRRRVELERALADHESQEQQQRSQLEQ 869
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1351 AELEAQELQRRM------------------QEEVARREEAAVDAQQQKRSIQ--EELQHLRQSSEAEIQAKAQQVEAAE- 1409
Cdd:PRK04863  870 AKEGLSALNRLLprlnlladetladrveeiREQLDEAEEAKRFVQQHGNALAqlEPIVSVLQSDPEQFEQLKQDYQQAQq 949
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1410 ---RSRMRIE--EEIRVVRLQLETTERQR-GGAEGELQ-ALRARAEEAEAQKRQAQEEAerlrRQVQDESQRKRQAEAEL 1482
Cdd:PRK04863  950 tqrDAKQQAFalTEVVQRRAHFSYEDAAEmLAKNSDLNeKLRQRLEQAEQERTRAREQL----RQAQAQLAQYNQVLASL 1025
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1483 alrvKAEAEAAREK-QRALQALDELRLQA-EEAERRLRQAEAE------RARQVQVALETAQRSAEVELQS--KRASFAE 1552
Cdd:PRK04863 1026 ----KSSYDAKRQMlQELKQELQDLGVPAdSGAEERARARRDElharlsANRSRRNQLEKQLTFCEAEMDNltKKLRKLE 1101
                         650
                  ....*....|....
gi 254675251 1553 KTAQLERTLQEEHV 1566
Cdd:PRK04863 1102 RDYHEMREQVVNAK 1115
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1355-1552 6.97e-08

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 58.04  E-value: 6.97e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1355 AQELQR-RMQEEVARREEAavDAQQQKRSIQEELQHLRQSSEAEI-QAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQ 1432
Cdd:COG3064    61 VQQYGRiQSQQSSAKKGEQ--QRKKKEEQVAEELKPKQAAEQERLkQLEKERLKAQEQQKQAEEAEKQAQLEQKQQEEQA 138
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1433 RggaegeLQALRARAeEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEE 1512
Cdd:COG3064   139 R------KAAAEQKK-KAEAAKAKAAAEAAKLKAAAEAKKKAEEAAKAAEEAKAKAEAAAAKKKAEAEAKAAAEKAKAEA 211
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 254675251 1513 AERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAE 1552
Cdd:COG3064   212 EAKAKAEKKAEAAAEEKAAAEKKKAAAKAKADKAAAAAKA 251
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1685-2247 8.10e-08

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 58.92  E-value: 8.10e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1685 AETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTS--EKSKQRLEAEAGRFR 1762
Cdd:PRK03918  186 KRTENIEELIKEKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEKELEslEGSKRKLEEKIRELE 265
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1763 E-LAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERV-LTEKLAAIS-EATRLKTEA---EIALKEKEAENERLRRLAE 1836
Cdd:PRK03918  266 ErIEELKKEIEELEEKVKELKELKEKAEEYIKLSEFYEeYLDELREIEkRLSRLEEEIngiEERIKELEEKEERLEELKK 345
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1837 DEAFQRRRLEEQAALHKA--DIEERLAQLRKASES----ELERQKGLVEDTLRQRRQVEEEImalkvsfEKAAAGKAELE 1910
Cdd:PRK03918  346 KLKELEKRLEELEERHELyeEAKAKKEELERLKKRltglTPEKLEKELEELEKAKEEIEEEI-------SKITARIGELK 418
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1911 LELGRIRSNAEdtmrskeqaELEAARQ------RQLAAEEEQRRREAEERVQRSLAAE----EEAARQRKVALEEVERLK 1980
Cdd:PRK03918  419 KEIKELKKAIE---------ELKKAKGkcpvcgRELTEEHRKELLEEYTAELKRIEKElkeiEEKERKLRKELRELEKVL 489
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1981 AKVEEARRLRERAEQESARQLQLAQEAAQKrlqAEEKAHAFvvqqreeelqqtlQQEQNMLDRLRSEAEAARRAAEEAEE 2060
Cdd:PRK03918  490 KKESELIKLKELAEQLKELEEKLKKYNLEE---LEKKAEEY-------------EKLKEKLIKLKGEIKSLKKELEKLEE 553
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2061 AREQAEREAAQSRKQVEE-AERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFA 2139
Cdd:PRK03918  554 LKKKLAELEKKLDELEEElAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFE 633
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2140 EQTLRQKA--QVEQELTTLRLQLEETDHQKSI-----LDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARI 2212
Cdd:PRK03918  634 ELAETEKRleELRKELEELEKKYSEEEYEELReeyleLSRELAGLRAELEELEKRREEIKKTLEKLKEELEEREKAKKEL 713
                         570       580       590
                  ....*....|....*....|....*....|....*
gi 254675251 2213 EAENRALilrdkdntqRFLEEEAEKMKQVAEEAAR 2247
Cdd:PRK03918  714 EKLEKAL---------ERVEELREKVKKYKALLKE 739
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
1518-2436 8.52e-08

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 58.83  E-value: 8.52e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1518 RQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREeaerelE 1597
Cdd:TIGR00618   56 RRSEVIRSLNSLYAAPSEAAFAELEFSLGTKIYRVHRTLRCTRSHRKTEQPEQLYLEQKKGRGRILAAKKSET------E 129
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1598 RWQLKAnealrLRLQAEEVAQQKSLAQADAEKqkeeaereaRRRGKAEEQAVRQRELaeQELEKQRQLAEGTAQQRLAAE 1677
Cdd:TIGR00618  130 EVIHDL-----LKLDYKTFTRVVLLPQGEFAQ---------FLKAKSKEKKELLMNL--FPLDQYTQLALMEFAKKKSLH 193
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1678 QELIrlrAETEQGEQQRQLLEEELARLqheataaTQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK--QRLE 1755
Cdd:TIGR00618  194 GKAE---LLTLRSQLLTLCTPCMPDTY-------HERKQVLEKELKHLREALQQTQQSHAYLTQKREAQEEQLKkqQLLK 263
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1756 AEAGRFRELAEEAARLRALAEEAKRQRQLAEedaarqraeaervLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLA 1835
Cdd:TIGR00618  264 QLRARIEELRAQEAVLEETQERINRARKAAP-------------LAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKR 330
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1836 EDEAFQRRRLEEQAALHKADIEERLAQLRKASESELERQKGLVEDTLRQR-RQVEEEIMALKVSFEKAAAGKAELELELG 1914
Cdd:TIGR00618  331 AAHVKQQSSIEEQRRLLQTLHSQEIHIRDAHEVATSIREISCQQHTLTQHiHTLQQQKTTLTQKLQSLCKELDILQREQA 410
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1915 RIrsNAEDTMRSKEQAELEAAR-QRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERA 1993
Cdd:TIGR00618  411 TI--DTRTSAFRDLQGQLAHAKkQQELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRK 488
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1994 EQESARQLQLAQEaaQKRLQAEEKAHAFVVQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAaqsr 2073
Cdd:TIGR00618  489 KAVVLARLLELQE--EPCPLCGSCIHPNPARQDIDNPGPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLK---- 562
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2074 kqvEEAERLKQSAEEQAQAQAQAQAAAEKLRKeaEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2153
Cdd:TIGR00618  563 ---EQMQEIQQSFSILTQCDNRSKEDIPNLQN--ITVRLQDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQC 637
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2154 TTlRLQLEETdhqkSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEE 2233
Cdd:TIGR00618  638 SQ-ELALKLT----ALHALQLTLTQERVREHALSIRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETH 712
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2234 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEAT-RLKAEAELLQQQKELAQE---QAR 2309
Cdd:TIGR00618  713 IEEYDREFNEIENASSSLGSDLAAREDALNQSLKELMHQARTVLKARTEAHFNNNeEVTAALQTGAELSHLAAEiqfFNR 792
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2310 RLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQAraeedaqRFRKQAEEIGEKLHRTELAT 2389
Cdd:TIGR00618  793 LREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLG-------EITHQLLKYEECSKQLAQLT 865
                          890       900       910       920       930
                   ....*....|....*....|....*....|....*....|....*....|.
gi 254675251  2390 QEKVTLVQTLE----IQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQL 2436
Cdd:TIGR00618  866 QEQAKIIQLSDklngINQIKIQFDGDALIKFLHEITLYANVRLANQSEGRF 916
Myosin_tail_1 pfam01576
Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and ...
1691-2569 9.29e-08

Myosin tail; The myosin molecule is a multi-subunit complex made up of two heavy chains and four light chains it is a fundamental contractile protein found in all eukaryote cell types. This family consists of the coiled-coil myosin heavy chain tail region. The coiled-coil is composed of the tail from two molecules of myosin. These can then assemble into the macromolecular thick filament. The coiled-coil region provides the structural backbone the thick filament.


Pssm-ID: 426331 [Multi-domain]  Cd Length: 1081  Bit Score: 58.63  E-value: 9.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1691 EQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEmEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRE------- 1763
Cdd:pfam01576    4 EEEMQAKEEELQKVKEKQQKAESELKELEKKHQQLCEE-KNILAEQLQAETELFAEAEEMRARLAARKQELEEilhelea 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1764 -LAEEAARLRALAEEAKR--------QRQLAEEDAARQRAEAERVLTE-KLAAISEATRLKTEAEIAL-KEKEAENERLR 1832
Cdd:pfam01576   83 rLEEEEERSQQLQNEKKKmqqhiqdlEEQLEEEEAARQKLQLEKVTTEaKIKKMEEDILLLEDQNNKLqKERKLLEERIS 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1833 ----RLAEDE----AFQRRRLEEQAALhkADIEERLAQLRK-------------ASESELERQ----KGLVEDTLRQRRQ 1887
Cdd:pfam01576  163 eftsNLAEEEekskSLNKLKNKHEAMI--SDLEDRLKKEEKgrqelekakrkleGESSDLQEQiaelQAQIAELRAQLAK 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1888 VEEEIMALKVSFEKAAAGKAELE---LELGRIRSNAEDTMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEE 1964
Cdd:pfam01576  241 KEEELQAALARLEEETAQKNAALkklRELEAQLSELQEDLESERAARAKAEKQRRDLGEELEALKTELEDTLDTTAAQQE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1965 AARQRKvalEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQNMLDRL 2044
Cdd:pfam01576  321 LRSKRE---QEVTELKKALEEETRSHEAQLQEMRQKHTQALEELTEQLEQAKRNKASLEKAKQALESENAELQAELRSLQ 397
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2045 RSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAeqeaarraqaeqaalKQ 2124
Cdd:pfam01576  398 QAKQDSEHKRKKLEGQLQELQSRLSESERQRAELAEKLSKLQSELESVSSLLNEAEGKNIKLS---------------KD 462
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2125 KQAADAEMEKHKKFAEQTLRQK-------AQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQrsqVEEELFS 2197
Cdd:pfam01576  463 VSSLESQLQDTQELLQEETRQKlnlssrlRQLEDEKNSLQEQLEEEEEAKRNVERQLQTLQAQLSDLKKK---LEEDAGA 539
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2198 VRvQMEElGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQvaeEAARLSVAAQeaaRLRQLAEEDLAQQRALAEKML 2277
Cdd:pfam01576  540 VE-ALEE-GRKRLQRELEALTQRLEEKAAAYDKLEKTKNRLQQ---ELDDLLVDLD---HQRQLVSNLEKKQKKFDQMLA 611
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2278 KEKMQAVQEA-TRLKAEAELLQQQKElAQEQARRLQEdkeqmAQQLVEETQGFQRTLEAERQrqlEMSAEAERLKLRMAE 2356
Cdd:pfam01576  612 EEKAISARYAeERDRAEAEAREKETK-ALSLARALEE-----ALDAKEELERQNKQLRAEME---DLVSSKDDVGKNVHE 682
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2357 MSRAQARAEEDAQRFRKQAEEIGEKLHRTELAtqeKVTLVQTLEIQRQQSDHD---------------AERLREAIAELE 2421
Cdd:pfam01576  683 LERSKRALEQQVEEMKTQLEELEDELQATEDA---KLRLEVNMQALKAQFERDlqardeqgeekrrqlVKQVRELEAELE 759
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2422 RE----------KEKLKQEAKLLQLKSEEMQTVQQEQILQetqaLQKSFLSEKDslLQRErfIEQEKAKLEQLFqdevAK 2491
Cdd:pfam01576  760 DErkqraqavaaKKKLELDLKELEAQIEAANKGRDEAVKQ----LKKLQAQMKD--LQRE--LDEARASRDEIF----AQ 827
                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251  2492 AKQLREEQQRQQQQMEQEKQELMASmeEARRRQREAEegvrrkQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEE 2569
Cdd:pfam01576  828 SKESEKKLKSLEAELLQLQEDLAAA--ERARRQAQQE------RDELAEEIASGNSGKSALLDEKRRLEARIAQLEEE 897
PLEC smart00250
Plectin repeat;
4004-4040 9.45e-08

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 50.56  E-value: 9.45e-08
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   4004 IRLLEAQIATGGIIDPEESHRLPVEVAYKRGLFDEEM 4040
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1317-1570 1.20e-07

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 225177 [Multi-domain]  Cd Length: 548  Bit Score: 57.92  E-value: 1.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1317 EQQRAEERERLAEVEAALEKQRQLAEAHAQAK-AQAELE--------AQELQRRMQEEVARREEAAVDAQQQKRSIQEEL 1387
Cdd:COG2268   215 RIAQVLQDAEIAENEAEKETEIAIAEANRDAKlVELEVEqqpagktaEQTREVKIILAETEAEVAAWKAETRREAEQAEI 294
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1388 QHLRQSSEAEIQAKA--QQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1465
Cdd:COG2268   295 LAEQAIQEEKAQAEQevQHAKALEAREMRVGLIERQKETELEPQERSYFINAAQRQAQEEAKAAANIAEAIGAQAEAAVE 374
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1466 rqvqdESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAER----------RLR-QAEAERARQVQVALET 1534
Cdd:COG2268   375 -----TARETEEAERAEQAALVAAAEAAEQEQVEIAVRAEAAKAEAEAQAaeikaeaeaiREKgKAEAEAKRALAEAIQV 449
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|
gi 254675251 1535 AQRSAEVELQSKR----ASFAEKTAQLERTLQEEHVTVAQ 1570
Cdd:COG2268   450 LGDAAAAELFKALvqalPEVAEEAAQPMKNIDSEKVRVIG 489
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
1612-1795 1.31e-07

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 57.12  E-value: 1.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1612 QAEEVAQQKslaQADAEKQKEEAEREArrrgKAEEQAVRQRELAEQELEKQRQLAEGTAQQ----RLAAEQELIRLRAET 1687
Cdd:PRK09510   88 QAEELQQKQ---AAEQERLKQLEKERL----AAQEQKKQAEEAAKQAALKQKQAEEAAAKAaaaaKAKAEAEAKRAAAAA 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1688 EQGEQQRQLLEEELARLQHEATAatqkRQELEAElAKVRAEMEvllaSKARAEEESRSTSEK-SKQRLEAEAGRFRELAE 1766
Cdd:PRK09510  161 KKAAAEAKKKAEAEAAKKAAAEA----KKKAEAE-AAAKAAAE----AKKKAEAEAKKKAAAeAKKKAAAEAKAAAAKAA 231
                         170       180
                  ....*....|....*....|....*....
gi 254675251 1767 EAArlRALAEEAKRQRQLAEEDAARQRAE 1795
Cdd:PRK09510  232 AEA--KAAAEKAAAAKAAEKAAAAKAAAE 258
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
1612-1798 1.61e-07

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 56.78  E-value: 1.61e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1612 QAEEVAQQKSlAQADAEKQKEEaerearrrgKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1691
Cdd:TIGR02794   51 QANRIQQQKK-PAAKKEQERQK---------KLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQ 120
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1692 QQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE---EA 1768
Cdd:TIGR02794  121 AEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKakaEA 200
                          170       180       190
                   ....*....|....*....|....*....|
gi 254675251  1769 ARLRALAEEAKRQRQLAeedAARQRAEAER 1798
Cdd:TIGR02794  201 AKAKAAAEAAAKAEAEA---AAAAAAEAER 227
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1642-1850 1.92e-07

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 56.88  E-value: 1.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1642 GKAEEQAVRQRELAEQELEKQRQLAEgTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAE 1721
Cdd:COG3064    65 GRIQSQQSSAKKGEQQRKKKEEQVAE-ELKPKQAAEQERLKQLEKERLKAQEQQKQAEEAEKQAQLEQKQQEEQARKAAA 143
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1722 LAKVRAEmevllaskaraEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLT 1801
Cdd:COG3064   144 EQKKKAE-----------AAKAKAAAEAAKLKAAAEAKKKAEEAAKAAEEAKAKAEAAAAKKKAEAEAKAAAEKAKAEAE 212
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 254675251 1802 EKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAA 1850
Cdd:COG3064   213 AKAKAEKKAEAAAEEKAAAEKKKAAAKAKADKAAAAAKAAERKAAAAAL 261
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
1620-1851 1.96e-07

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 56.96  E-value: 1.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1620 KSLAQADA-EKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQR-------LAAEQELIRLRAETEQGE 1691
Cdd:COG4372    71 SGVFQLDDiRPQLRALRTELGTAQGEKRAAETEREAARSELQKARQEREAVRQELaaarqnlAKAQQELARLTKQAQDLQ 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1692 QQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSekskQRLEAEAGRFRELAEEAARL 1771
Cdd:COG4372   151 TRLKTLAEQRRQLEAQAQSLQASQKQLQASATQLKSQVLDLKLRSAQIEQEAQNLA----TRANAAQARTEELARRAAAA 226
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1772 RALAEEA----KRQRQLAEEDAARQRAEAERvlteklaaiseATRLKtEAEIALKEKEAENERLRRLAEDeaFQRRRLEE 1847
Cdd:COG4372   227 QQTAQAIqqrdAQISQKAQQIAARAEQIRER-----------ERQLQ-RLETAQARLEQEVAQLEAYYQA--YVRLRQQA 292

                  ....
gi 254675251 1848 QAAL 1851
Cdd:COG4372   293 AATQ 296
CH_PLS3_rpt3 cd21331
third calponin homology (CH) domain found in plastin-3; Plastin-3, also called T-plastin, is ...
7-114 2.22e-07

third calponin homology (CH) domain found in plastin-3; Plastin-3, also called T-plastin, is an actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Plastin-3 contains four copies of the CH domain. This model corresponds to the third CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409180  Cd Length: 134  Bit Score: 52.70  E-value: 2.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    7 ERDRVQKKTFTKWVNKhlIKAQRHISDLYEDLRDGHNLISLLEVL-------SGDSLPREKGRMRFHKLQNVQIALDYLR 79
Cdd:cd21331    18 EGETREERTFRNWMNS--LGVNPHVNHLYGDLQDALVILQLYEKIkvpvdwnKVNKPPYPKLGANMKKLENCNYAVELGK 95
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 254675251   80 HR-QVKLVNIRNDDIADGNPKLTLGLIWTIILHFQI 114
Cdd:cd21331    96 HPaKFSLVGIGGQDLNDGNPTLTLALVWQLMRRYTL 131
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 ...
1290-1939 2.26e-07

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 substr. MG1655 [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 225638 [Multi-domain]  Cd Length: 1480  Bit Score: 57.59  E-value: 2.26e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1290 ELTTLTSQYIKFISETLRRMEEEERLAEQQRAEE---RERLAEVEAALEKQRQLAEAHAQAKAQAElEAQELQRRMQEEV 1366
Cdd:COG3096   359 ELTIRLEEQNEVVEEANERQEENEARAEAAELEVdelKSQLADYQQALDVQQTRAIQYQQAIAALE-RAKELCHLPDLTA 437
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1367 ARREEAAVDAQQQKRSIQEELQHLRQSSEAEiQAKAQQVEAAERSRMRIEEEI------RVVRLQLETTERQRGGAEGEl 1440
Cdd:COG3096   438 DSAEEWLETFQAKEEEATEKLLSLEQKMSMA-QAAHSQFEQAYQLVVAIAGELarseawDVARELLREGPDQRHLAEQV- 515
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1441 QALRARAEEAEAQKRQaQEEAERLRRQVQDESQRKRQAEAELALR---------VKAEAEAAREKQRAL-QALDELRLQA 1510
Cdd:COG3096   516 QPLRMRLSELEQRLRQ-QQSAERLLADFCKRQGKNLDAEELEALHqelealiesLSDSVSNAREQRMALrQEQEQLQSRI 594
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1511 EEAERRlrqaeAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERtlqEEHVTVAQlreeaerraqqqAEAERARE 1590
Cdd:COG3096   595 QSLMQR-----APVWLAAQNALEQLSEQSGEEFTDSQDVTEYMQQLLER---EREATVER------------DELGARKN 654
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1591 EAERELERW-QLKANEALRLRLQAE--------EVAQQKSLAQA-------------------DAEKQKEEAER---EAR 1639
Cdd:COG3096   655 ALDEEIERLsQPGGSEDQRLNALAErfggvllsEIYDDVTIEDApyfsalygpsrhaivvpdlSQVKEHLEGLTdcpEDL 734
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1640 RRGKAEEQAVRQRELAEQELEK-------QRQL-----AEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQ-- 1705
Cdd:COG3096   735 YLIEGDPQSFDDSVFSVDELEKavvvkiaDRQWrysrfPEIPLFGRAAREQRLESLHAERDVLSERHATLSFDVQKTQrl 814
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1706 ----------HEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAE---AGRFRELAEEAarLR 1772
Cdd:COG3096   815 hqafsrfigsHLAVAFEADPEAEIRQLNSRRNELERALSNHENDNQQQRIQFDQAKEGVTALnrlIPQLNLLADES--LA 892
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1773 ALAEEAKRQRQLAEEDAARQRAEAerVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAF------QRRR-- 1844
Cdd:COG3096   893 DRVEEIRERLDEAQEAARFIQQHG--NTLSKLEPIASVLQSDPEQFEQLKEDYAQAQQMQRQARQQAFaltevvQRRAhf 970
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1845 -LEEQAAL--HKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELG----RIR 1917
Cdd:COG3096   971 sYSDSAEMlsENSDLNEKLRQRLEQAEAERTRAREQLRQHQAQLSQYNQVLASLKSSYDTKKELLNELQQELQdigvRAD 1050
                         730       740
                  ....*....|....*....|....*
gi 254675251 1918 SNAEDTMRSKE---QAELEAARQRQ 1939
Cdd:COG3096  1051 SGAEERARIRRdelHAQLSTNRSRR 1075
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1391-1684 2.36e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227278 [Multi-domain]  Cd Length: 420  Bit Score: 56.65  E-value: 2.36e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1391 RQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAqeeaerlrrQVQD 1470
Cdd:COG4942    40 LKQIQKEIAALEKKIREQQDQRAKLEKQLKSLETEIASLEAQLIETADDLKKLRKQIADLNARLNAL---------EVQE 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1471 ESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAE---RRLRQAEAERARQVQVALETAQRSAE-VELQSK 1546
Cdd:COG4942   111 REQRRRLAEQLAALQRSGRNPPPALLVSPEDAQRSVRLAIYYGAlnpARAERIDALKATLKQLAAVRAEIAAEqAELTTL 190
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1547 RASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAeaerareeaerelerwQLKANEAlRLRLQAEEVAQQKSLAQAD 1626
Cdd:COG4942   191 LSEQRAQQAKLAQLLEERKKTLAQLNSELSADQKKLE----------------ELRANES-RLKNEIASAEAAAAKAREA 253
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251 1627 AEkqkeeaerearrrgkAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLR 1684
Cdd:COG4942   254 AA---------------AAEAAAARARAAEAKRTGETYKPTAPEKMLISSTGGFGALR 296
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
1976-2651 2.52e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 57.37  E-value: 2.52e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1976 VERLKAKVEEARRLRERAEQESARQLQLA----QEAAQKRLQAEEKAHAfvVQQREEELQQTLQQEQNMLDRLRSEAEAA 2051
Cdd:TIGR02168  202 LKSLERQAEKAERYKELKAELRELELALLvlrlEELREELEELQEELKE--AEEELEELTAELQELEEKLEELRLEVSEL 279
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2052 RRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAE 2131
Cdd:TIGR02168  280 EEEIEELQKELYALANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAE 359
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2132 MEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEE--LGKLK 2209
Cdd:TIGR02168  360 LEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEaeLKELQ 439
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2210 ARIEAENRAlilrdkdntqrfLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEkMLKEKMQAVQEATR 2289
Cdd:TIGR02168  440 AELEELEEE------------LEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLD-SLERLQENLEGFSE 506
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2290 lkAEAELLQQQKELAQEQARrlqedkeqmAQQLVEETQGFQRTLEA---ERQRQLEMS------------AEAERLKLRM 2354
Cdd:TIGR02168  507 --GVKALLKNQSGLSGILGV---------LSELISVDEGYEAAIEAalgGRLQAVVVEnlnaakkaiaflKQNELGRVTF 575
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2355 AEMSRAQARAEEDAQRFRKQAEE--IGEKLHRTELATQEKVTL---------VQTLEI---QRQQSDHDA---------- 2410
Cdd:TIGR02168  576 LPLDSIKGTEIQGNDREILKNIEgfLGVAKDLVKFDPKLRKALsyllggvlvVDDLDNaleLAKKLRPGYrivtldgdlv 655
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2411 ------------------------ERLREAIAELEREKEKLKQEAKLLQLKSEEMQTvQQEQILQETQALQKSFLSEKDS 2466
Cdd:TIGR02168  656 rpggvitggsaktnssilerrreiEELEEKIEELEEKIAELEKALAELRKELEELEE-ELEQLRKELEELSRQISALRKD 734
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2467 LLQRERFIEQEKAKLEQL-------------FQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEGVRR 2533
Cdd:TIGR02168  735 LARLEAEVEQLEERIAQLskelteleaeieeLEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTL 814
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2534 KQEELQHLEQQRQQQEKLLAEENQRLRERLQRLE--EEHRAALAHS-----EIATTQAASTKALPNGRDAPDGPSVEAEP 2606
Cdd:TIGR02168  815 LNEEAANLRERLESLERRIAATERRLEDLEEQIEelSEDIESLAAEieeleELIEELESELEALLNERASLEEALALLRS 894
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*
gi 254675251  2607 EYTFEGLRQKVPAQQLQEAGILSQEELQRLAQGHTTVAELTQRED 2651
Cdd:TIGR02168  895 ELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRID 939
mukB PRK04863
chromosome partition protein MukB;
1317-1720 2.98e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 57.27  E-value: 2.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1317 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRM------------------QEEVARREEAAVDAQQ 1378
Cdd:PRK04863  836 EAELRQLNRRRVELERALADHESQEQQQRSQLEQAKEGLSALNRLLprlnlladetladrveeiREQLDEAEEAKRFVQQ 915
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1379 QKRSIQ--EELQHLRQSSEAEIQAKAQQVEAAE----RSRMRIE--EEIRVVRLQLETTERQR-GGAEGELQ-ALRARAE 1448
Cdd:PRK04863  916 HGNALAqlEPIVSVLQSDPEQFEQLKQDYQQAQqtqrDAKQQAFalTEVVQRRAHFSYEDAAEmLAKNSDLNeKLRQRLE 995
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1449 EAEAQKRQAQEEAerlrRQVQDESQRKRQAEAELalrvKAEAEAAREK-QRALQALDELRLQA-EEAERRLRQAEAE--- 1523
Cdd:PRK04863  996 QAEQERTRAREQL----RQAQAQLAQYNQVLASL----KSSYDAKRQMlQELKQELQDLGVPAdSGAEERARARRDElha 1067
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1524 ---RARQVQVALETAQRSAEVELQS--KRASFAEKTAQLERTLQEEHVT--VAQLREEAERRAQQQAEAERAREEAEREL 1596
Cdd:PRK04863 1068 rlsANRSRRNQLEKQLTFCEAEMDNltKKLRKLERDYHEMREQVVNAKAgwCAVLRLVKDNGVERRLHRRELAYLSADEL 1147
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1597 ERWQLKANEALRLrlqaeevaqqkslAQADAEKqkEEAEREARRRGKAEEQAVRQRELAEQEL-EKQRQLAEGTAQQRLA 1675
Cdd:PRK04863 1148 RSMSDKALGALRL-------------AVADNEH--LRDVLRLSEDPKRPERKVQFYIAVYQHLrERIRQDIIRTDDPVEA 1212
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 254675251 1676 AEQ---ELIRLRAETEQGEQQRQLLEEELA-----RLQHEATAATQKRQELEA 1720
Cdd:PRK04863 1213 IEQmeiELSRLTEELTSREQKLAISSESVAniirkTIQREQNRIRMLNQGLQN 1265
DUF4659 pfam15558
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ...
1307-1568 3.08e-07

Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.


Pssm-ID: 434789 [Multi-domain]  Cd Length: 374  Bit Score: 56.21  E-value: 3.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1307 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVAR--REEAAVDAQQQKRSIQ 1384
Cdd:pfam15558   21 QLMRELQQQAALAWEELRRSDQKVQETLERERRLLLQQSQEQWQAQKEQRKRRLGREERRRRdrREKQVIEKESRWREQA 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1385 EELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRvvrlqletterqRGGAEGELQALRARAEEAEaQKRQAQEEAERL 1464
Cdd:pfam15558  101 EDQENQRQEKLERAAQEAEQRKQCQEQNLKEKEEEL------------QALREQNGLQLQERLEQAC-HKRQLKELEEQK 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1465 RRQVQDESQRKRQA--EAELALRVKAEAEAARE--KQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAE 1540
Cdd:pfam15558  168 KVQENNLSELLNHQarKVLVDCQAKAEELLRRLslEQSLQRSQENYEQLVEERHRELREKAQKEEEQFQRAKLRAEEKEE 247
                          250       260
                   ....*....|....*....|....*...
gi 254675251  1541 VELQSKRASFAEKTAQLERTLQEEHVTV 1568
Cdd:pfam15558  248 EQQEHKEALAELADQKIQQARSVAHKTV 275
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
1717-2568 3.29e-07

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 57.00  E-value: 3.29e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1717 ELEAELAKVRAEMEVLlasKARAEEESRSTSEKSKQRleaeaGRFRELAEEAARLRALAEEaKRQRQLAEEDAARQRAEA 1796
Cdd:TIGR02169  167 EFDRKKEKALEELEEV---EENIERLDLIIDEKRQQL-----ERLRREREKAERYQALLKE-KREYEGYELLKEKEALER 237
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1797 ERVLTEKlaAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHkadIEERLAQLrkasESELERQKG 1876
Cdd:TIGR02169  238 QKEAIER--QLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLR---VKEKIGEL----EAEIASLER 308
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1877 LVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNaedtmRSKEQAELEAARQRqlaaeeEQRRREAEERVQ 1956
Cdd:TIGR02169  309 SIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKR-----RDKLTEEYAELKEE------LEDLRAELEEVD 377
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1957 RSLAAEEEAARQRKVALEEVERLKAKVE-EARRLRERAEQESARQLQLAQEAAQKRLQ-AEEKAHAFVVQQREEELQQTL 2034
Cdd:TIGR02169  378 KEFAETRDELKDYREKLEKLKREINELKrELDRLQEELQRLSEELADLNAAIAGIEAKiNELEEEKEDKALEIKKQEWKL 457
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2035 QQEQNMLDRLRSEAEAARRAAEEAEEAREqaereaaQSRKQVEEAERLKQSAEEQAQAQAqaqaaaeklrkeaeqeaarr 2114
Cdd:TIGR02169  458 EQLAADLSKYEQELYDLKEEYDRVEKELS-------KLQRELAEAEAQARASEERVRGGR-------------------- 510
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2115 aqaeqaalkqkqAADAEMEKHKKFAEQTLRQKAQVEQELTTL-------RLQL----EETDHQKSIldEELQRLKA-EVT 2182
Cdd:TIGR02169  511 ------------AVEEVLKASIQGVHGTVAQLGSVGERYATAievaagnRLNNvvveDDAVAKEAI--ELLKRRKAgRAT 576
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2183 EAARQRSQVEEELFSVRVQMEELGKLKARIEAENR-----ALILRDKDNTQRfLEEEAEKMKQV---------------- 2241
Cdd:TIGR02169  577 FLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKyepafKYVFGDTLVVED-IEAARRLMGKYrmvtlegelfeksgam 655
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2242 ----AEEAARLSVAAQEAARLRQLAEE---------DLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQA 2308
Cdd:TIGR02169  656 tggsRAPRGGILFSRSEPAELQRLRERleglkrelsSLQSELRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKL 735
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2309 RRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARaeEDAQRFRKQAEEIGEKLHRTELA 2388
Cdd:TIGR02169  736 KERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSH--SRIPEIQAELSKLEEEVSRIEAR 813
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2389 TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMqtvqqEQILQETQALQKSfLSEKDSLL 2468
Cdd:TIGR02169  814 LREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEEL-----EEELEELEAALRD-LESRLGDL 887
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2469 QRERfiEQEKAKLEQLfQDEVAKAKQLREEQQRQQQQMEqekqelmASMEEARRRQREAEEGVRRKQEElqhleQQRQQQ 2548
Cdd:TIGR02169  888 KKER--DELEAQLREL-ERKIEELEAQIEKKRKRLSELK-------AKLEALEEELSEIEDPKGEDEEI-----PEEELS 952
                          890       900
                   ....*....|....*....|
gi 254675251  2549 EKLLAEENQRLRERLQRLEE 2568
Cdd:TIGR02169  953 LEDVQAELQRVEEEIRALEP 972
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1311-1499 3.40e-07

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 225177 [Multi-domain]  Cd Length: 548  Bit Score: 56.38  E-value: 3.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1311 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEElqhl 1390
Cdd:COG2268   262 EQTREVKIILAETEAEVAAWKAETRREAEQAEILAEQAIQEEKAQAEQEVQHAKALEAREMRVGLIERQKETELEP---- 337
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1391 rQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQA---LRARAEEAEAQKRQAQEEAERLRRQ 1467
Cdd:COG2268   338 -QERSYFINAAQRQAQEEAKAAANIAEAIGAQAEAAVETARETEEAERAEQAalvAAAEAAEQEQVEIAVRAEAAKAEAE 416
                         170       180       190
                  ....*....|....*....|....*....|..
gi 254675251 1468 VQDESQRkrqAEAElALRVKAEAEAAREKQRA 1499
Cdd:COG2268   417 AQAAEIK---AEAE-AIREKGKAEAEAKRALA 444
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1792-2182 4.21e-07

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 56.29  E-value: 4.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1792 QRAEAERVLTEKLAAIsEATRLKTEAEialkEKEAENERLRRLAEDEAFQRRRLEEQAALHKAdiEERLAQLRkasESEL 1871
Cdd:pfam17380  281 QKAVSERQQQEKFEKM-EQERLRQEKE----EKAREVERRRKLEEAEKARQAEMDRQAAIYAE--QERMAMER---EREL 350
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1872 ERQKglVEDTLRQRRQVEEEIMALKVSFEKaaagkaELE-LELGRIRSNaedtmrSKEQAELEAARQRQLAaeeeqrrre 1950
Cdd:pfam17380  351 ERIR--QEERKRELERIRQEEIAMEISRMR------ELErLQMERQQKN------ERVRQELEAARKVKIL--------- 407
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1951 aeervqrslaaEEEAARQRKVALEEVERLKAKVEEARRLR-ERAEQESARQLQLAQEAAQKRLQAEEKAHAFVVQQReee 2029
Cdd:pfam17380  408 -----------EEERQRKIQQQKVEMEQIRAEQEEARQREvRRLEEERAREMERVRLEEQERQQQVERLRQQEEERK--- 473
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2030 lqqtlqqeqnmldRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAeq 2109
Cdd:pfam17380  474 -------------RKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEERRREA-- 538
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251  2110 eaarraqaeqaalKQKQAADAEMEKHKKFAEQTLRqkaqVEQELTTLRLQLEETDHQKSILDEELQRLKAEVT 2182
Cdd:pfam17380  539 -------------EEERRKQQEMEERRRIQEQMRK----ATEERSRLEAMEREREMMRQIVESEKARAEYEAT 594
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
1388-1676 4.45e-07

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 56.11  E-value: 4.45e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1388 QHLRQSsEAEIQAKAQQVEAAERSRMRIEEeiRVVRLQLETTERQrggaegelqalrARAEEAEAQKRQAQEEA-----E 1462
Cdd:PRK05035  429 QYYRQA-KAEIRAIEQEKKKAEEAKARFEA--RQARLEREKAARE------------ARHKKAAEARAAKDKDAvaaalA 493
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1463 RLRRQVQDESQRKRQAEAELALRVKAEAEA-AREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEV 1541
Cdd:PRK05035  494 RVKAKKAAATQPIVIKAGARPDNSAVIAAReARKAQARARQAEKQAAAAADPKKAAVAAAIARAKAKKAAQQAANAEAEE 573
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1542 ELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAeaerareeaerelerwqlkANEALRLRLQAEEVAQQKS 1621
Cdd:PRK05035  574 EVDPKKAAVAAAIARAKAKKAAQQAASAEPEEQVAEVDPKKA-------------------AVAAAIARAKAKKAEQQAN 634
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 254675251 1622 LAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAA 1676
Cdd:PRK05035  635 AEPEEPVDPRKAAVAAAIARAKARKAAQQQANAEPEEAEDPKKAAVAAAIARAKA 689
PTZ00491 PTZ00491
major vault protein; Provisional
2281-2426 4.71e-07

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 56.18  E-value: 4.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2281 MQAVQEATRlkaeaELLQQQKELA-------QEQARRLQ-EDKEQMAQQLVEEtQGFQRTLEAERQRQLEMSAEAERLKL 2352
Cdd:PTZ00491  638 VEPVDERTR-----DSLQKSVQLAieittksQEAAARHQaELLEQEARGRLER-QKMHDKAKAEEQRTKLLELQAESAAV 711
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254675251 2353 RMAEMSRAQARAEEDAQRFRKQAEeigekLHRTEL-ATQEKVTLVQTLEIQRQQSDHDAERlREAIAELEREKEK 2426
Cdd:PTZ00491  712 ESSGQSRAEALAEAEARLIEAEAE-----VEQAELrAKALRIEAEAELEKLRKRQELELEY-EQAQNELEIAKAK 780
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4107-4135 5.27e-07

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 48.49  E-value: 5.27e-07
                           10        20
                   ....*....|....*....|....*....
gi 254675251  4107 IVDPETGKEMSVYEAYRKGLIDHQTYLEL 4135
Cdd:pfam00681   11 IIDPVTGERLSVEEALKRGLIDPETAQKL 39
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
2239-2455 5.55e-07

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 55.24  E-value: 5.55e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2239 KQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQM 2318
Cdd:TIGR02794   46 GAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQAEEKQKQAEEAK 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2319 AQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKvtlvQT 2398
Cdd:TIGR02794  126 AKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKAEEAKAKAE----AA 201
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251  2399 LEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQA 2455
Cdd:TIGR02794  202 KAKAAAEAAAKAEAEAAAAAAAEAERKADEAELGDIFGLASGSNAEKQGGARGAAAG 258
mukB PRK04863
chromosome partition protein MukB;
1119-1544 6.41e-07

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 56.12  E-value: 6.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1119 RGAQEvgERLQQRHGERDVEVERW--RERVTQLLERWQ-----------AVLAQTDVRQrELEQLGRQLRY-YRESADpl 1184
Cdd:PRK04863  781 RAARE--KRIEQLRAEREELAERYatLSFDVQKLQRLHqafsrfigshlAVAFEADPEA-ELRQLNRRRVElERALAD-- 855
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1185 sawlQDAKRRQEQIQAVPIANCQAAREQLRQEKALLEEiERHGEKVEECQ---KFAKQYINAIKDYELQLitykAQLEPV 1261
Cdd:PRK04863  856 ----HESQEQQQRSQLEQAKEGLSALNRLLPRLNLLAD-ETLADRVEEIReqlDEAEEAKRFVQQHGNAL----AQLEPI 926
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1262 AS-----PAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQYIKF-ISETLRRMEEEERLAEQQRAeereRLAEVEAALE 1335
Cdd:PRK04863  927 VSvlqsdPEQFEQLKQDYQQAQQTQRDAKQQAFALTEVVQRRAHFsYEDAAEMLAKNSDLNEKLRQ----RLEQAEQERT 1002
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1336 KQRqlaEAHAQAKAQAeleAQELQRRMQEEVARREeaavdAQQQKRSIQEELQHL--RQSSEAEIQAKAQqveaaersRM 1413
Cdd:PRK04863 1003 RAR---EQLRQAQAQL---AQYNQVLASLKSSYDA-----KRQMLQELKQELQDLgvPADSGAEERARAR--------RD 1063
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1414 RIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAE-------RLRRQVQDESQRKRQAEAELALRV 1486
Cdd:PRK04863 1064 ELHARLSANRSRRNQLEKQLTFCEAEMDNLTKKLRKLERDYHEMREQVVnakagwcAVLRLVKDNGVERRLHRRELAYLS 1143
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251 1487 KAEAEAAREKqrALQALdelrlqaeeaerRLRQAEAERARQVQVALETAQRsAEVELQ 1544
Cdd:PRK04863 1144 ADELRSMSDK--ALGAL------------RLAVADNEHLRDVLRLSEDPKR-PERKVQ 1186
PLEC smart00250
Plectin repeat;
3685-3720 6.77e-07

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 48.25  E-value: 6.77e-07
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 254675251   3685 RLLLEAQAATGFLLDPVKGERLTVDEAVRKGLVGPE 3720
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
2212-2464 7.71e-07

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 225177 [Multi-domain]  Cd Length: 548  Bit Score: 55.22  E-value: 7.71e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2212 IEAENRALILRDKdNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKmqavQEATRLK 2291
Cdd:COG2268   208 LDALGRRRIAQVL-QDAEIAENEAEKETEIAIAEANRDAKLVELEVEQQPAGKTAEQTREVKIILAETE----AEVAAWK 282
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2292 AEAELLQQQKELAQEQARRLQE-DKEQMAQQLVEETQGFQRTLEAERQRQLEMSA-EAERLKLRMAEMSRAQARAE-EDA 2368
Cdd:COG2268   283 AETRREAEQAEILAEQAIQEEKaQAEQEVQHAKALEAREMRVGLIERQKETELEPqERSYFINAAQRQAQEEAKAAaNIA 362
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2369 QRFRKQAEEIGEKLHRTELA-TQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEmQTVQQE 2447
Cdd:COG2268   363 EAIGAQAEAAVETARETEEAeRAEQAALVAAAEAAEQEQVEIAVRAEAAKAEAEAQAAEIKAEAEAIREKGKA-EAEAKR 441
                         250
                  ....*....|....*..
gi 254675251 2448 QILQETQALQKSFLSEK 2464
Cdd:COG2268   442 ALAEAIQVLGDAAAAEL 458
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
1311-1506 7.91e-07

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 54.81  E-value: 7.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1311 EEERLAEQQRAEERERLAEveAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVAR-REEAAVDAQQQKRSIQEElqh 1389
Cdd:PRK09510  107 EKERLAAQEQKKQAEEAAK--QAALKQKQAEEAAAKAAAAAKAKAEAEAKRAAAAAKKaAAEAKKKAEAEAAKKAAA--- 181
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1390 lRQSSEAEIQAKAQQVEAAErsrmrieeeirvvrlqletterQRGGAEGELQALRARAEEAEAQKRQAQEEAErlrrqvq 1469
Cdd:PRK09510  182 -EAKKKAEAEAAAKAAAEAK----------------------KKAEAEAKKKAAAEAKKKAAAEAKAAAAKAA------- 231
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 254675251 1470 desqRKRQAEAELALRVKAEAEAAREKQRAlqALDEL 1506
Cdd:PRK09510  232 ----AEAKAAAEKAAAAKAAEKAAAAKAAA--EVDDL 262
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1457-1992 8.20e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 55.46  E-value: 8.20e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1457 AQEEAERLRRQVQDESQRKR---QAEAELALRVKaeaEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALE 1533
Cdd:PRK03918  163 AYKNLGEVIKEIKRRIERLEkfiKRTENIEELIK---EKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEE 239
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1534 TAQRSAEVE-LQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERraqqqaeaerareeaereLERWQLKANEALRLRLQ 1612
Cdd:PRK03918  240 IEELEKELEsLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKE------------------LKELKEKAEEYIKLSEF 301
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1613 AEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAE--------GTAQQRLAAEQELIRLR 1684
Cdd:PRK03918  302 YEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEEleerhelyEEAKAKKEELERLKKRL 381
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1685 AETEQGEQQRQLLEEELAR--LQHEATAATQKRQELEAELAKVRAEMEVLLASKARA-------EEESR----------- 1744
Cdd:PRK03918  382 TGLTPEKLEKELEELEKAKeeIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCpvcgrelTEEHRkelleeytael 461
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1745 STSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAE--------------EDAARQRAEAERVLTEKLAAISEA 1810
Cdd:PRK03918  462 KRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLKELAEqlkeleeklkkynlEELEKKAEEYEKLKEKLIKLKGEI 541
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1811 TRLKTEAEIA---LKEKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKA---------SESELERQKGLV 1878
Cdd:PRK03918  542 KSLKKELEKLeelKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFyneylelkdAEKELEREEKEL 621
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1879 EDTLRQRRQVEEEIMALKVSFEKAaagKAELElELGRIRSnaEDTMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRS 1958
Cdd:PRK03918  622 KKLEEELDKAFEELAETEKRLEEL---RKELE-ELEKKYS--EEEYEELREEYLELSRELAGLRAELEELEKRREEIKKT 695
                         570       580       590
                  ....*....|....*....|....*....|....
gi 254675251 1959 LAAEEEAARQRKVALEEVERLKAKVEEARRLRER 1992
Cdd:PRK03918  696 LEKLKEELEEREKAKKELEKLEKALERVEELREK 729
DUF812 pfam05667
Protein of unknown function (DUF812); This family consists of several eukaryotic proteins of ...
2122-2309 1.07e-06

Protein of unknown function (DUF812); This family consists of several eukaryotic proteins of unknown function.


Pssm-ID: 428574 [Multi-domain]  Cd Length: 601  Bit Score: 55.02  E-value: 1.07e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2122 LKQKQAADAEMEKHKKFAEQTLRQKAQvEQELTTLRLQLEETDHQKSILDEELQRLKAEVTeaarqrsQVEEELFSVRVQ 2201
Cdd:pfam05667  308 FTNEEAPAATSSPPTKAETEEELQQQR-EEELEELQEQLEELESSIEELEKEIKKLESSIK-------QVEEELEELKEQ 379
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2202 MEELG---KLKARI-----EAENRALILrdkdntQRFLEEEAEKMKQVAE--EAARLSVAAQEAARLRQLAEEDLAQQRA 2271
Cdd:pfam05667  380 NEELEkqyKVKKKTldllpDAEENIAKL------QALVEASAQRLVELAGqwEKHRVPLIEEYRALKEAKSNKESESQRK 453
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|.
gi 254675251  2272 LAE-KMLKEKMQAVQEATRLKAE--AELLQQQKELAQEQAR 2309
Cdd:pfam05667  454 LEEiKELREKIKEVAEEARSKEElyKQLVAEYERLPKDVNR 494
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
1302-1569 1.11e-06

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 227606 [Multi-domain]  Cd Length: 833  Bit Score: 55.03  E-value: 1.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1302 ISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAqaELEAQELQRRMQEEVARREEAAVDAQQQKR 1381
Cdd:COG5281   344 VLGIGREDKQAALLAAKLAAEKLARVTAQGALNARLKLAQDDLTQAEL--NYAAADQAANQEGALNAREDEAEVLSTQEE 421
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1382 SiqeELQHLRQSSEAEIQAKAQQVEA-AERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEE 1460
Cdd:COG5281   422 R---RDILKNLLADAEKRTARQEELNkALAKAKILQADKAAKAYQEDILQREAQSRGKTAAAERSQEQMTAALKALLAFQ 498
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1461 aerlrRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQaldelRLQAEEAERRLRQAEAERARQvQVALETAQRSAE 1540
Cdd:COG5281   499 -----QQIADLSGAKEKASDQKSLLWKAEEQYALLKEEAKQ-----RQLQEQKALLEHKKETLEYTS-QLAELLDQQADR 567
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 254675251 1541 VEL--------------------QSKRASFAEKTAQLERTLQEEHVTVA 1569
Cdd:COG5281   568 FELsaqaagsqkergsdlyrealAQNAAALNKALNELAAYWSALDLLQG 616
DUF3523 pfam12037
Domain of unknown function (DUF3523); This presumed domain is functionally uncharacterized. ...
1285-1404 1.15e-06

Domain of unknown function (DUF3523); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 257 to 277 amino acids in length. This domain is found associated with pfam00004. This domain has a conserved LER sequence motif.


Pssm-ID: 432279 [Multi-domain]  Cd Length: 264  Bit Score: 53.44  E-value: 1.15e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1285 RTRYSELTTLTSQYIKFI----SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELeaqelqR 1360
Cdd:pfam12037   56 QTRQAELQAKIKEYEAAQeqleIERQRVEYEERRKTLQEETKQKQQRAQYQDELARKRYQDQLEAQRRRNEEL------L 129
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 254675251  1361 RMQEEVARREEAAVDAQQQKRSIQEEL----QHLRQSSEAEIQAKAQQ 1404
Cdd:pfam12037  130 RMQEESVAKQEAMRIQAQRRQTEEHEAelrrETEMAKAEAEAEARAKE 177
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1306-1523 1.24e-06

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 54.18  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1306 LRRMEEEERLAEQQRAEERERLAEVEaaleKQRQLAEahaqakaQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQE 1385
Cdd:COG3064    67 IQSQQSSAKKGEQQRKKKEEQVAEEL----KPKQAAE-------QERLKQLEKERLKAQEQQKQAEEAEKQAQLEQKQQE 135
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1386 ElQHLRQSSEAEIQAKAQQVEAAERSRmrieeeirvvRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLR 1465
Cdd:COG3064   136 E-QARKAAAEQKKKAEAAKAKAAAEAA----------KLKAAAEAKKKAEEAAKAAEEAKAKAEAAAAKKKAEAEAKAAA 204
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251 1466 RQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAE 1523
Cdd:COG3064   205 EKAKAEAEAKAKAEKKAEAAAEEKAAAEKKKAAAKAKADKAAAAAKAAERKAAAAALD 262
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1039-1485 1.24e-06

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 435022 [Multi-domain]  Cd Length: 1112  Bit Score: 55.11  E-value: 1.24e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1039 LEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKTHEEQLKEaqaVPATLQE----LEATKASLKKLRAQAEAQQPVFNTL 1114
Cdd:pfam15921  460 LEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSD---LTASLQEkeraIEATNAEITKLRSRVDLKLQELQHL 536
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1115 RDE---LRGAQEVGERLQQRHGERDVEVERWR---ERVTQLLERW----QAVLAQTDVRQRELEQLGRQLRYYRESADPL 1184
Cdd:pfam15921  537 KNEgdhLRNVQTECEALKLQMAEKDKVIEILRqqiENMTQLVGQHgrtaGAMQVEKAQLEKEINDRRLELQEFKILKDKK 616
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1185 SAWLQDAKRRQEQIQAVPIANCQAAREQLRQEKALLEEIERHGEKVEECQkfaKQYINAIKDYELQLITYKAQLEPVASP 1264
Cdd:pfam15921  617 DAKIRELEARVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSR---NELNSLSEDYEVLKRNFRNKSEEMETT 693
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1265 AKKPKVQsgsesviqeyvdLRTRYSELTTltsqyikfISETLRRMEEEERLAeqqraeererlaeVEAALEKQRQLAEAH 1344
Cdd:pfam15921  694 TNKLKMQ------------LKSAQSELEQ--------TRNTLKSMEGSDGHA-------------MKVAMGMQKQITAKR 740
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1345 AQAKAqaeleaqelqrrMQEEVARREEAAVDAQQQKRSIQEELQHLRQsseaeiqakaqqveaaersrmrieeeirvvrl 1424
Cdd:pfam15921  741 GQIDA------------LQSKIQFLEEAMTNANKEKHFLKEEKNKLSQ-------------------------------- 776
                          410       420       430       440       450       460
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251  1425 QLETTERQRGGAEGELQALRA---RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALR 1485
Cdd:pfam15921  777 ELSTVATEKNKMAGELEVLRSqerRLKEKVANMEVALDKASLQFAECQDIIQRQEQESVRLKLQ 840
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
2129-2590 1.26e-06

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 55.23  E-value: 1.26e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2129 DAEMEKHKKFAEQTLRQKAQVEQELTT--------LRLQLEETDHQKSILDEELQRLKAEV---TEAARQRSQVEEELFS 2197
Cdd:pfam12128  364 KALTGKHQDVTAKYNRRRSKIKEQNNRdiagikdkLAKIREARDRQLAVAEDDLQALESELreqLEAGKLEFNEEEYRLK 443
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2198 VRvqmeeLGKLKARIeaeNRALILRDKDNTQRFLEEEAEKMKQVAEEA-ARLSVAAQEAARLRQLAEEDLAQQRaLAEKM 2276
Cdd:pfam12128  444 SR-----LGELKLRL---NQATATPELLLQLENFDERIERAREEQEAAnAEVERLQSELRQARKRRDQASEALR-QASRR 514
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2277 LKEKMQAVQEATR------------LKAEAELLQQQ--KELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLE 2342
Cdd:pfam12128  515 LEERQSALDELELqlfpqagtllhfLRKEAPDWEQSigKVISPELLHRTDLDPEVWDGSVGGELNLYGVKLDLKRIDVPE 594
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2343 MSAEAERLKLRMAEMSRA-------QARAEEDAQRFRKQAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLR 2414
Cdd:pfam12128  595 WAASEEELRERLDKAEEAlqsarekQAAAEEQLVQANGELEKASREETFARTALKNaRLDLRRLFDEKQSEKDKKNKALA 674
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2415 EAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQ---ETQALQKSFLSEKDSLLQR-----ERFIEQEKAKLEQLfQ 2486
Cdd:pfam12128  675 ERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREartEKQAYWQVVEGALDAQLALlkaaiAARRSGAKAELKAL-E 753
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2487 DEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRL 2566
Cdd:pfam12128  754 TWYKRDLASLGVDPDVIAKLKREIRTLERKIERIAVRRQEVLRYFDWYQETWLQRRPRLATQLSNIERAISELQQQLARL 833
                          490       500
                   ....*....|....*....|....
gi 254675251  2567 EEEHRAALAhsEIATTQAASTKAL 2590
Cdd:pfam12128  834 IADTKLRRA--KLEMERKASEKQQ 855
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
2132-2435 1.31e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 54.64  E-value: 1.31e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2132 MEKHKKFAEQTLRQKAQVEQELTTlrlQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKAR 2211
Cdd:TIGR04523  389 LESQINDLESKIQNQEKLNQQKDE---QIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRES 465
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2212 IEAENRAL------ILRDKDNTQRFLEEEAEKMKQVAEEAarlsvaaqeaarlRQLAEE--DLAQQRALaekmLKEKMQa 2283
Cdd:TIGR04523  466 LETQLKVLsrsinkIKQNLEQKQKELKSKEKELKKLNEEK-------------KELEEKvkDLTKKISS----LKEKIE- 527
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2284 vqeatrlKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEaerqrqlemsaeaeRLKLRMAEMSRAQAR 2363
Cdd:TIGR04523  528 -------KLESEKKEKESKISDLEDELNKDDFELKKENLEKEIDEKNKEIE--------------ELKQTQKSLKKKQEE 586
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675251  2364 AEEDAQRFRKQAEEIGEKLhrtelatQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQ 2435
Cdd:TIGR04523  587 KQELIDQKEKEKKDLIKEI-------EEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIK 651
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
1447-1727 1.38e-06

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 54.26  E-value: 1.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1447 AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELAlRVKAEAEAAREKQralqaldelrlqaEEAERRLRQAEAERAR 1526
Cdd:COG4372    69 LRSGVFQLDDIRPQLRALRTELGTAQGEKRAAETERE-AARSELQKARQER-------------EAVRQELAAARQNLAK 134
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1527 QVQVALETAQRSAevELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAErraqqqaeaerareeaerelerwQLKAnEA 1606
Cdd:COG4372   135 AQQELARLTKQAQ--DLQTRLKTLAEQRRQLEAQAQSLQASQKQLQASAT-----------------------QLKS-QV 188
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1607 LRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRrgkaeEQAVRQRELAEQELEKQRQlaegTAQQRLAAEQELIRLRAE 1686
Cdd:COG4372   189 LDLKLRSAQIEQEAQNLATRANAAQARTEELARR-----AAAAQQTAQAIQQRDAQIS----QKAQQIAARAEQIRERER 259
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 254675251 1687 TEQG-EQQRQLLEEELARLQHEATAATQKR-QELEAELAKVRA 1727
Cdd:COG4372   260 QLQRlETAQARLEQEVAQLEAYYQAYVRLRqQAAATQRGQVLA 302
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
1345-1559 1.49e-06

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 53.70  E-value: 1.49e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1345 AQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAqqveaAERSRMRIEEEIRvvrl 1424
Cdd:TIGR02794   49 AQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQ-----AEQAAKQAEEKQK---- 119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1425 qletterqrggaegelQALRARAEEAEAQKRQAQEEAERlrrQVQDESQRKRQAEAelalRVKAEAEAAREKQRALQALD 1504
Cdd:TIGR02794  120 ----------------QAEEAKAKQAAEAKAKAEAEAER---KAKEEAAKQAEEEA----KAKAAAEAKKKAEEAKKKAE 176
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251  1505 ELRLQAEEAERRLRQ--AEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLER 1559
Cdd:TIGR02794  177 AEAKAKAEAEAKAKAeeAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAE 233
MscK COG3264
Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];
1332-1507 1.70e-06

Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225803 [Multi-domain]  Cd Length: 835  Bit Score: 54.31  E-value: 1.70e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1332 AALEKQRQLAEAHaqaKAQAELEAQELQRRMQEEVARREEAAVD-AQQQKRSIQEELQHLRQSSEAEIQAkAQQVEAAER 1410
Cdd:COG3264    11 ELLQSRRELLTAE---SAQLEAALQLLQEAVNSKRQEEAEPAAEeAELQAELIQQELAINDQLSQALNQQ-TERLNALAS 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1411 SRMRIEEeirvVRLQLETTERQrggAEGELQALRARAEEAEAQKRQAQ----EEAERLRRQVQDESQRKRQAEAEL-ALR 1485
Cdd:COG3264    87 DDRQLAN----LLLQLLQSSRT---IREQIAVLRGSLLLSRILLQQLGplpeAGQPQEQFEVTQERDALQAEKAYInALE 159
                         170       180
                  ....*....|....*....|..
gi 254675251 1486 VKAEAEAAREKQRALQALDELR 1507
Cdd:COG3264   160 GQAEQLTAEVRDILDQILDTRR 181
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The ...
2068-2657 1.98e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 54.59  E-value: 1.98e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2068 EAAQSRKQVEEAERLKQ-SAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEqtlRQK 2146
Cdd:pfam02463  212 YYQLKEKLELEEEYLLYlDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQE---EEL 288
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2147 AQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDN 2226
Cdd:pfam02463  289 KLLAKEEEELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKL 368
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2227 TQR-------------FLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDL---AQQRALAEKMLKEKMQAVQEATRL 2290
Cdd:pfam02463  369 EQLeeellakkkleseRLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLkeeKKEELEILEEEEESIELKQGKLTE 448
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2291 KAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETqgfQRTLEAERQRQLEMSAeAERLKLRMAEMSRAQARAEED--- 2367
Cdd:pfam02463  449 EKEELEKQELKLLKDELELKKSEDLLKETQLVKLQE---QLELLLSRQKLEERSQ-KESKARSGLKVLLALIKDGVGgri 524
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2368 ---AQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQqsdhdaeRLREAIAELEREKEKLKQEAKLLQLKSEEMQTV 2444
Cdd:pfam02463  525 isaHGRLGDLGVAVENYKVAISTAVIVEVSATADEVEERQ-------KLVRALTELPLGARKLRLLIPKLKLPLKSIAVL 597
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2445 QQEQILQETQALQKSFLSEKDSLLQRErFIEQEKAKLEQLFQdEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQ 2524
Cdd:pfam02463  598 EIDPILNLAQLDKATLEADEDDKRAKV-VEGILKDTELTKLK-ESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKEL 675
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2525 REAEEGVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSEIATTQAASTKALpngrdapdgPSVEA 2604
Cdd:pfam02463  676 LEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLL---------KQKID 746
                          570       580       590       600       610
                   ....*....|....*....|....*....|....*....|....*....|...
gi 254675251  2605 EPEYTFEGLRQKVPAQQLQEAGILSQEELQRLAQGHTTvaELTQREDVYRYLK 2657
Cdd:pfam02463  747 EEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTE--KLKVEEEKEEKLK 797
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1295-1534 2.07e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227278 [Multi-domain]  Cd Length: 420  Bit Score: 53.57  E-value: 2.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1295 TSQYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAAL-EKQRQLAEAHAQ-AKAQAELEAQELQRRMQEEVARREEA 1372
Cdd:COG4942    43 IQKEIAALEKKIREQQDQRAKLEKQLKSLETEIASLEAQLiETADDLKKLRKQiADLNARLNALEVQEREQRRRLAEQLA 122
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1373 AVDAQQQKRSIQEELqhlRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEA 1452
Cdd:COG4942   123 ALQRSGRNPPPALLV---SPEDAQRSVRLAIYYGALNPARAERIDALKATLKQLAAVRAEIAAEQAELTTLLSEQRAQQA 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1453 QKRQAQEEAERLRRQVQDESQRKRQAEAELALRvkaEAEAAREKQRALQALDELRLQAEEAER---RLRQAEAERARQVQ 1529
Cdd:COG4942   200 KLAQLLEERKKTLAQLNSELSADQKKLEELRAN---ESRLKNEIASAEAAAAKAREAAAAAEAaaaRARAAEAKRTGETY 276

                  ....*
gi 254675251 1530 VALET 1534
Cdd:COG4942   277 KPTAP 281
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
2139-2375 2.09e-06

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 53.88  E-value: 2.09e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2139 AEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRA 2218
Cdd:COG4372    69 LRSGVFQLDDIRPQLRALRTELGTAQGEKRAAETEREAARSELQKARQEREAVRQELAAARQNLAKAQQELARLTKQAQD 148
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2219 LilrdkdntqrfleeeAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQ 2298
Cdd:COG4372   149 L---------------QTRLKTLAEQRRQLEAQAQSLQASQKQLQASATQLKSQVLDLKLRSAQIEQEAQNLATRANAAQ 213
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251 2299 Q-QKELAQEQARRLQEDkeQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQA 2375
Cdd:COG4372   214 ArTEELARRAAAAQQTA--QAIQQRDAQISQKAQQIAARAEQIRERERQLQRLETAQARLEQEVAQLEAYYQAYVRLR 289
Caldesmon pfam02029
Caldesmon;
1310-1564 2.10e-06

Caldesmon;


Pssm-ID: 426572 [Multi-domain]  Cd Length: 490  Bit Score: 53.72  E-value: 2.10e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1310 EEEERLAEQQRAEERERLAEVEAALEKQRQL--AEAHAQAKAQAELEAQELQRRMQEE----VARREEAAVDAQQQKRSI 1383
Cdd:pfam02029   59 DEEEAFLDRTAKREERRQKRLQEALERQKELdpTITDEQASKPRSTENTPEEKNNTEEeeksSTRKERYEIEEREVSEKS 138
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1384 QEELQHLRQSSEAEIQAKAQQVEAAERSR-----------MRIEEEIRVVRLQ----LETTERQRGGAEGE--------- 1439
Cdd:pfam02029  139 YEKDDKKAVPKEEEEEEDAKTEEEEEEEEeekkvskkkkeKLKDEYTSKVFLDqkkgHPEQKSQNGALEEVtsmtvklkr 218
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1440 ------LQALRARAEEAEAQKRQAQEEAERLRRQVQD-ESQ-----RKRQAEAELALRvkaEAEAAREKQRALQaldelr 1507
Cdd:pfam02029  219 tertfsQKSLVAEDEEEGAAFLEAEQKLEELRRRRQEkESQefeklRQKQQEAELELE---ELKKKREERRKIL------ 289
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251  1508 lqaEEAERRLRQAEAERarqvQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEE 1564
Cdd:pfam02029  290 ---EEEEQRRKQEEAER----KAREEEEKRRMKEEIERRRAEAAEKRQKMEDTSSAE 339
PLEC smart00250
Plectin repeat;
3890-3927 2.37e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.71  E-value: 2.37e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 254675251   3890 QKFLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTA 3927
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
CH_PLS3_rpt1 cd21325
first calponin homology (CH) domain found in plastin-3; Plastin-3, also called T-plastin, is ...
12-120 2.38e-06

first calponin homology (CH) domain found in plastin-3; Plastin-3, also called T-plastin, is an actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Plastin- 3 contains four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409174  Cd Length: 148  Bit Score: 50.06  E-value: 2.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   12 QKKTFTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR----EKGRMRFHKLQNVQIALDYL 78
Cdd:cd21325    25 EKYAFVNWINKalendpdcrHVIPMNPNTDDLFKAVGDGIVLCKMINLSVPDTIDErainKKKLTPFIIQENLNLALNSA 104
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 254675251   79 RHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQVS 120
Cdd:cd21325   105 SAIGCHVVNIGAEDLRAGKPHLVLGLLWQIIKIGLFADIELS 146
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1600-1798 2.46e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227278 [Multi-domain]  Cd Length: 420  Bit Score: 53.19  E-value: 2.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1600 QLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEaerearrrgkaEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQE 1679
Cdd:COG4942    74 EIASLEAQLIETADDLKKLRKQIADLNARLNALE-----------VQEREQRRRLAEQLAALQRSGRNPPPALLVSPEDA 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1680 L------IRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLlaskARAEEESRSTSEKSKQR 1753
Cdd:COG4942   143 QrsvrlaIYYGALNPARAERIDALKATLKQLAAVRAEIAAEQAELTTLLSEQRAQQAKL----AQLLEERKKTLAQLNSE 218
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 254675251 1754 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAER 1798
Cdd:COG4942   219 LSADQKKLEELRANESRLKNEIASAEAAAAKAREAAAAAEAAAAR 263
ERM pfam00769
Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at ...
2306-2454 2.60e-06

Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at their amino terminus. This family represents the rest of these proteins.


Pssm-ID: 425860 [Multi-domain]  Cd Length: 247  Bit Score: 51.86  E-value: 2.60e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2306 EQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRT 2385
Cdd:pfam00769    2 EEAEREKQELEERLKQYEEETRKAQEELEESEETAELLEEKLRVAEEEAELLEQKAQEAEEEKERLEESAEMEAEEKEQL 81
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251  2386 ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQ 2454
Cdd:pfam00769   82 ERELREAQEEVARLEEESERKEEEAERLQEELEEAREEEEEAKEKLLAASTSPSHHHSEESENEDDEEE 150
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
1067-1783 2.92e-06

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 53.60  E-value: 2.92e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1067 EEVLKTHEEQLKEAQAVPATLQELEATKASLKKLRAQAEAqqpvfntLRDELRGAQEVGERLQQRHGERDVEVERW-RER 1145
Cdd:pfam07111   80 EEVRLLRETSLQQKMRLEAQAMELDALAVAEKAGQAEAEG-------LRAALAGAEMVRKNLEEGSQRELEEIQRLhQEQ 152
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1146 VTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESAdplSAWLQDAKRRQEQIQAvpiaNCQAAREQLRQEKALLEEIER 1225
Cdd:pfam07111  153 LSSLTQAHEEALSSLTSKAEGLEKSLNSLETKRAGE---AKQLAEAQKEAELLRK----QLSKTQEELEAQVTLVESLRK 225
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1226 H-GEKV------EECQKFAKQYINAIKDYELQLITYKAQLEPVaspakKPKVQSGSESVIQEYVDLRTRYSELTTLTSQY 1298
Cdd:pfam07111  226 YvGEQVppevhsQTWELERQELLDTMQHLQEDRADLQATVELL-----QVRVQSLTHMLALQEEELTRKIQPSDSLEPEF 300
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1299 IKFISETLRRMEEEE-RLAEQQRAEERERLAEVEaalEKQRQLAEAHAQAKAQAELEAQeLQRRMQEEVARREEAAVDAq 1377
Cdd:pfam07111  301 PKKCRSLLNRWREKVfALMVQLKAQDLEHRDSVK---QLRGQVAELQEQVTSQSQEQAI-LQRALQDKAAEVEVERMSA- 375
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1378 qqkRSIQEELQhlrQSSEAEIQAKaQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQA 1457
Cdd:pfam07111  376 ---KGLQMELS---RAQEARRRQQ-QQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQAVARIPSLSNRLSYAVRKVHTI 448
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1458 QEEAER--LRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQAldELRLQA----EEAERRLRQAEAERARQVQVA 1531
Cdd:pfam07111  449 KGLMARkvALAQLRQESCPPPPPAPPVDADLSLELEQLREERNRLDA--ELQLSAhliqQEVGRAREQGEAERQQLSEVA 526
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1532 LETAQrsaevELQSKRASFAEKTAQLERTLQEEhvtvaqlreeaerraqqqaeaerareeaerelerwQLKANEALRLRl 1611
Cdd:pfam07111  527 QQLEQ-----ELQRAQESLASVGQQLEVARQGQ-----------------------------------QESTEEAASLR- 565
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1612 qAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRlAAEQELIRLRAETEQGE 1691
Cdd:pfam07111  566 -QELTQQQEIYGQALQEKVAEVETRLREQLSDTKRRLNEARREQAKAVVSLRQIQHRATQEK-ERNQELRRLQDEARKEE 643
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1692 QQR-----QLLEEE----LARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESR-----STSEKSKQRLEAE 1757
Cdd:pfam07111  644 GQRlarrvQELERDknlmLATLQQEGLLSRYKQQRLLAVLPSGLDKKSVVSSPRPECSASAPipaavPTRESIKGSLTVL 723
                          730       740
                   ....*....|....*....|....*.
gi 254675251  1758 AGRFRELAEEAARLRALAEEAKRQRQ 1783
Cdd:pfam07111  724 LDNLQGLSEAISREEAVCQEDNQDTC 749
SbcC COG0419
DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];
2270-2638 3.08e-06

DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair];


Pssm-ID: 223496 [Multi-domain]  Cd Length: 908  Bit Score: 53.61  E-value: 3.08e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2270 RALAEKMLKEKMQAVQEATRLkaeaELLQQQKELAQEQARRLQEDKEQMAQQLveetqgfqrTLEAERQRQLEMSAEAER 2349
Cdd:COG0419   146 DAFLKSKPKERKEILDELFGL----EKYEKLSELLKEVIKEAKAKIEELEGQL---------SELLEDIEDLLEALEEEL 212
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2350 LKLRmaemSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQ 2429
Cdd:COG0419   213 KELK----KLEEIQEEQEEEELEQEIEALEERLAELEEEKERLEELKARLLEIESLELEALKIREEELRELERLLEELEE 288
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2430 EAKLL-QLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQ 2508
Cdd:COG0419   289 KIERLeELEREIEELEEELEGLRALLEELEELLEKLKSLEERLEKLEEKLEKLESELEELAEEKNELAKLLEERLKELEE 368
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2509 EKQELMASMEEARRRQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQRL---RERLQRLEEEHRAALAHSEIATTQAA 2585
Cdd:COG0419   369 RLEELEKELEKALERLKQLEEAIQELKEELAELSAALEEIQEELEELEKELeelERELEELEEEIKKLEEQINQLESKEL 448
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|...
gi 254675251 2586 STKALPNGRDAPDGPSVEAEPEYTFEGLRQKVPAQQLQEAGILSQEELQRLAQ 2638
Cdd:COG0419   449 MIAELAGAGEKCPVCGQELPEEHEKELLELYELELEELEEELSREKEEAELRE 501
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
1310-1475 3.19e-06

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 52.54  E-value: 3.19e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1310 EEEERLAEQQRAEERERLAEVEAAleKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQH 1389
Cdd:TIGR02794  101 EKAAKQAEQAAKQAEEKQKQAEEA--KAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKKKAEAE 178
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1390 LRQSSEAEIQAKAQQVEA-AERSRMRIEEEI----RVVRLQLETTERQRGGAEGELQALRARAEEAEAQK------RQAQ 1458
Cdd:TIGR02794  179 AKAKAEAEAKAKAEEAKAkAEAAKAKAAAEAaakaEAEAAAAAAAEAERKADEAELGDIFGLASGSNAEKqggargAAAG 258
                          170
                   ....*....|....*..
gi 254675251  1459 EEAERLRRQVQDESQRK 1475
Cdd:TIGR02794  259 SEVDKYAAIIQQAIQQN 275
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1306-1846 3.40e-06

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 428520 [Multi-domain]  Cd Length: 660  Bit Score: 53.19  E-value: 3.40e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1306 LRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAeahaQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQE 1385
Cdd:pfam05557   57 IRLLEKREAEAEEALREQAELNRLKKKNLEALNKKL----NEKESQLADAREVISCLKNELSELRRQIQRQELELSSTNS 132
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1386 ELQHLRQSSE------AEIQAKAQQVEAAERSRMRIEEEIR--VVRLQLET-------TERQRGGAEGELQALRARAEEA 1450
Cdd:pfam05557  133 ELEELQERLDlqkakaQEAEQLRQNLEAQQSSLAEAEQRIKelEFEIQSQEqdseivkNSKSELARIPELERELERLREH 212
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1451 EAQKRQAQEEAERLRRQVQDESQRKRQAEaelalrvKAEAEAAR---EKQRALQALDELRLQAEEAERRLRQAEAERARQ 1527
Cdd:pfam05557  213 NKHLNENIENKLLLKEEVEDLKRKLEREE-------GYREELATlelEKEKLEQELKSWEKLAQDTGLNLRSPEDLSRRI 285
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1528 VQvaletaqrsaeveLQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEaerareeaerelERWQLKANEAL 1607
Cdd:pfam05557  286 EQ-------------LQQREITLKEENSSLTSSARQLEKAQRELEQELAQYLKNIED------------LNKKLKRHKAL 340
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1608 RLRLQAEE--VAQQKSLAQA-----DAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTA----QQRLAA 1676
Cdd:pfam05557  341 VRRLQRRVllLTKERDGMRAilesyDKELTPSNYSPQLLERIEEAEDMTQDMQAHNEEMEAQLSVAEEELggykQQATTL 420
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1677 EQELIRLRAETEQGEQqrqlleeelARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK---QR 1753
Cdd:pfam05557  421 ERELQALRQQESLADP---------SYSKEEVDSLRRKLETLEAERQRLREQKNELEMELERRCLQGDYDPKKTKvlhLS 491
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1754 LEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTeklAAISEATRLKTEAEIAlkekEAENERLRr 1833
Cdd:pfam05557  492 MNPAAEAYQQRANDLEKLQAEIERLKRRLKKLEDDLEQVGSLPETTST---MNFKEVLELRKELESA----ELKNQRLK- 563
                          570
                   ....*....|...
gi 254675251  1834 laedEAFQRRRLE 1846
Cdd:pfam05557  564 ----EVFQAKIQE 572
PLEC smart00250
Plectin repeat;
3095-3131 3.58e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.32  E-value: 3.58e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3095 LRLLDAQLSTGGIVDPSKSHRVPLDVAYARGYLDKET 3131
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
CH_PLS1_rpt1 cd21323
first calponin homology (CH) domain found in plastin-1; Plastin-1, also called ...
12-119 3.64e-06

first calponin homology (CH) domain found in plastin-1; Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. It contains four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409172  Cd Length: 145  Bit Score: 49.66  E-value: 3.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   12 QKKTFTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR----EKGRMRFHKLQNVQIALDYL 78
Cdd:cd21323    25 EKVAFVNWINKalegdpdckHVVPMNPTDESLFKSLADGILLCKMINLSQPDTIDErainKKKLTPFTISENLNLALNSA 104
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 254675251   79 RHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQV 119
Cdd:cd21323   105 SAIGCTVVNIGSLDLKEGKPHLVLGLLWQIIKVGLFADIEI 145
PLEC smart00250
Plectin repeat;
2768-2803 3.84e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 46.32  E-value: 3.84e-06
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 254675251   2768 RLLEAQIATGGIIDPVHSHRVPVDVAYKRGYFDEEM 2803
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
2239-2489 4.25e-06

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 52.72  E-value: 4.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2239 KQVAEEAARLSVAAQEAARLRQL--AEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKE 2316
Cdd:COG4372    40 KQTAVLVTVLTGMLISAATLAILflLNRNLRSGVFQLDDIRPQLRALRTELGTAQGEKRAAETEREAARSELQKARQERE 119
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2317 QMAQQLVEETQGFQRTLeaerQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEkvtlV 2396
Cdd:COG4372   120 AVRQELAAARQNLAKAQ----QELARLTKQAQDLQTRLKTLAEQRRQLEAQAQSLQASQKQLQASATQLKSQVLD----L 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2397 QTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQalQKSFLSEKDSLLQR----ER 2472
Cdd:COG4372   192 KLRSAQIEQEAQNLATRANAAQARTEELARRAAAAQQTAQAIQQRDAQISQKAQQIAA--RAEQIRERERQLQRletaQA 269
                         250
                  ....*....|....*..
gi 254675251 2473 FIEQEKAKLEQLFQDEV 2489
Cdd:COG4372   270 RLEQEVAQLEAYYQAYV 286
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1654-1875 4.34e-06

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 52.26  E-value: 4.34e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1654 LAEQELEKQRQLAEGTAQqrlAAEQELIRLRAETEQGEQQRQLlEEELARLQHEATAATQKRQELEAELAKVRAEMEvll 1733
Cdd:COG3064    59 AVVQQYGRIQSQQSSAKK---GEQQRKKKEEQVAEELKPKQAA-EQERLKQLEKERLKAQEQQKQAEEAEKQAQLEQ--- 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1734 asKARAEEESRSTSEKSKQrleaeagrfrelaEEAARLRALAEEAKRQrqlAEEDAARqRAEAERVLTEKLAAISEATRL 1813
Cdd:COG3064   132 --KQQEEQARKAAAEQKKK-------------AEAAKAKAAAEAAKLK---AAAEAKK-KAEEAAKAAEEAKAKAEAAAA 192
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251 1814 KTEAEIALKEKEAENERLRRLAED-EAFQRRRLEEQAALHKADIEERLAQLRKASESELERQK 1875
Cdd:COG3064   193 KKKAEAEAKAAAEKAKAEAEAKAKaEKKAEAAAEEKAAAEKKKAAAKAKADKAAAAAKAAERK 255
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 ...
1312-2005 4.62e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 substr. MG1655 [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 225638 [Multi-domain]  Cd Length: 1480  Bit Score: 53.35  E-value: 4.62e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1312 EERLAEQQR----AEERERLAEVEAALEKQRQLAEAHAQAkAQAELEAQELQRRMQEEVarrEEAAVDAQQQKRSIQEEL 1387
Cdd:COG3096   300 QQLAAEQYRhvdmSRELAELNGAEGDLEADYQAASDHLNL-VQTALRQQEKIERYQADL---EELTIRLEEQNEVVEEAN 375
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1388 QHLRQSSE----AEIQAKAQQVEAAERSRMRIEEEIRVVRLQ-----LETTERQRGGAEGELQALRARAEEAEAQKRQAQ 1458
Cdd:COG3096   376 ERQEENEAraeaAELEVDELKSQLADYQQALDVQQTRAIQYQqaiaaLERAKELCHLPDLTADSAEEWLETFQAKEEEAT 455
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1459 EEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKqrALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRS 1538
Cdd:COG3096   456 EKLLSLEQKMSMAQAAHSQFEQAYQLVVAIAGELARSE--AWDVARELLREGPDQRHLAEQVQPLRMRLSELEQRLRQQQ 533
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1539 AEVELQS---KRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEE 1615
Cdd:COG3096   534 SAERLLAdfcKRQGKNLDAEELEALHQELEALIESLSDSVSNAREQRMALRQEQEQLQSRIQSLMQRAPVWLAAQNALEQ 613
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1616 VAQQKSLAQADAEKQKEEAEREARrrgKAEEQAVRQRELAEQELEKQRQLaEGTAQQRLAAEQELIRLrAETEQGEQQRQ 1695
Cdd:COG3096   614 LSEQSGEEFTDSQDVTEYMQQLLE---REREATVERDELGARKNALDEEI-ERLSQPGGSEDQRLNAL-AERFGGVLLSE 688
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1696 LLEE----------------ELARLQHEATAATQKRQELE---AELAKVRAEMEVLLASKARAEEESRSTSEKSKQRlEA 1756
Cdd:COG3096   689 IYDDvtiedapyfsalygpsRHAIVVPDLSQVKEHLEGLTdcpEDLYLIEGDPQSFDDSVFSVDELEKAVVVKIADR-QW 767
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1757 EAGRFREL-----AEEAARLRALAEE----AKRQRQLAEEDAARQRAEA--ERVLTEKLAAISEAtrlKTEAEIALKEKE 1825
Cdd:COG3096   768 RYSRFPEIplfgrAAREQRLESLHAErdvlSERHATLSFDVQKTQRLHQafSRFIGSHLAVAFEA---DPEAEIRQLNSR 844
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1826 aENERLRRLAEDEAF-QRRRLEEQAALHKADIEERLA-QLRKASESELERQKGLVEDTLRQRRQVEEEIMALKVSFekaa 1903
Cdd:COG3096   845 -RNELERALSNHENDnQQQRIQFDQAKEGVTALNRLIpQLNLLADESLADRVEEIRERLDEAQEAARFIQQHGNTL---- 919
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1904 agkAELELELGRIRSNAEDTMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLaaeEEAARQRKVALEEVERLKAKV 1983
Cdd:COG3096   920 ---SKLEPIASVLQSDPEQFEQLKEDYAQAQQMQRQARQQAFALTEVVQRRAHFSY---SDSAEMLSENSDLNEKLRQRL 993
                         730       740
                  ....*....|....*....|...
gi 254675251 1984 EEARRLRERA-EQESARQLQLAQ 2005
Cdd:COG3096   994 EQAEAERTRArEQLRQHQAQLSQ 1016
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3892-3930 4.64e-06

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 45.79  E-value: 4.64e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3892 FLEGTSCIAGVFVDATKERLSVYQAMKKGIIRPGTAFEL 3930
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
1327-1421 4.65e-06

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 53.03  E-value: 4.65e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1327 LAEVEAALEKQRQLAEAHAQAKAQAeleaQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLR-QSSEAEIQAKAQQV 1405
Cdd:PRK11448  144 LHALQQEVLTLKQQLELQAREKAQS----QALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQeKAAETSQERKQKRK 219
                          90
                  ....*....|....*....
gi 254675251 1406 EAAERSRMRI---EEEIRV 1421
Cdd:PRK11448  220 EITDQAAKRLelsEEETRI 238
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
2249-2527 4.66e-06

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 380155 [Multi-domain]  Cd Length: 1848  Bit Score: 53.30  E-value: 4.66e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2249 SVAAQEAARLRQLAEEDLAQQRALAEKmlkekmqavqeatrlkaeaellqqqkELAQEQARRLQEDKeqmaQQLVEETQG 2328
Cdd:NF012221 1538 SESSQQADAVSKHAKQDDAAQNALADK--------------------------ERAEADRQRLEQEK----QQQLAAISG 1587
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2329 FQRTLEAERQRQLEMSAEAERlklrmaemsraQARAEEdaqrfrkqAEEIgeklhrtelaTQEKVTLVQTLEIQRQQSDH 2408
Cdd:NF012221 1588 SQSQLESTDQNALETNGQAQR-----------DAILEE--------SRAV----------TKELTTLAQGLDALDSQATY 1638
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2409 DAE---RLREAIAE--LEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSllqrerfiEQEKAKLEQ 2483
Cdd:NF012221 1639 AGEsgdQWRNPFAGglLDRVQEQLDDAKKISGKQLADAKQRHVDNQQKVKDAVAKSEAGVAQG--------EQNQANAEQ 1710
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 254675251 2484 LFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRR-QREA 2527
Cdd:NF012221 1711 DIDDAKADAEKRKDDALAKQNEAQQAESDANAAANDAQSRgEQDA 1755
PRK07735 PRK07735
NADH-quinone oxidoreductase subunit C;
1304-1540 4.79e-06

NADH-quinone oxidoreductase subunit C;


Pssm-ID: 236081 [Multi-domain]  Cd Length: 430  Bit Score: 52.29  E-value: 4.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1304 ETLRRMEEE--ERLAEQQRAEERERLAE---VEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQ 1378
Cdd:PRK07735   13 EAARRAKEEarKRLVAKHGAEISKLEEEnreKEKALPKNDDMTIEEAKRRAAAAAKAKAAALAKQKREGTEEVTEEEKAK 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1379 QKRSIQEElqhlrqsseaeiqAKAQQVEAAERSRMRIEEeirvvrlqlETTERQRGGAEGELQALRARAEEAEAQKRQAQ 1458
Cdd:PRK07735   93 AKAKAAAA-------------AKAKAAALAKQKREGTEE---------VTEEEKAAAKAKAAAAAKAKAAALAKQKREGT 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1459 EEAERLRRQVQDESQRKRQAEAelalrVKAEAeAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRS 1538
Cdd:PRK07735  151 EEVTEEEEETDKEKAKAKAAAA-----AKAKA-AALAKQKAAEAGEGTEEVTEEEKAKAKAKAAAAAKAKAAALAKQKAS 224

                  ..
gi 254675251 1539 AE 1540
Cdd:PRK07735  225 QG 226
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1702-2432 4.89e-06

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 52.80  E-value: 4.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1702 ARLQHEATAATQKRQELEAELAKVRAEME---VLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEA 1778
Cdd:pfam05483   81 SKLYKEAEKIKKWKVSIEAELKQKENKLQenrKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCNLL 160
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1779 KRQRQLAEEDAAR---QRAEAERVLT------EKLAAISEATRLKTE---AEIALKEKEaENERLRRLAEDEAFQRRRLE 1846
Cdd:pfam05483  161 KETCARSAEKTKKyeyEREETRQVYMdlnnniEKMILAFEELRVQAEnarLEMHFKLKE-DHEKIQHLEEEYKKEINDKE 239
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1847 EQAALHKADIEERlaqlrkasESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEDTMRS 1926
Cdd:pfam05483  240 KQVSLLLIQITEK--------ENKMKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMST 311
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1927 keqaeleaarQRQLAAEEEQRRREAEERVQRSLAAEEEAARQR---KVALEEVERLKAKVEEARRLRERAEQESARQLQL 2003
Cdd:pfam05483  312 ----------QKALEEDLQIATKTICQLTEEKEAQMEELNKAKaahSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLKI 381
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2004 AQEAAQKRLQAEEKAHAFVVQQREEelqqtlqqeqnmLDRLRSEAEAARRAAEEaeeareqaereaaqsRKQVEE-AERL 2082
Cdd:pfam05483  382 ITMELQKKSSELEEMTKFKNNKEVE------------LEELKKILAEDEKLLDE---------------KKQFEKiAEEL 434
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2083 KQSAEEQAQAQAQAQAAAEKLRkeaeQEAARRAQAEQAALKQKQAADAEMEKHK-KFAEQT------LRQKAQVEQELTT 2155
Cdd:pfam05483  435 KGKEQELIFLLQAREKEIHDLE----IQLTAIKTSEEHYLKEVEDLKTELEKEKlKNIELTahcdklLLENKELTQEASD 510
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2156 LRLQLEetDHQKSILDEELQ--RLKAEVTEAARQRSQVEEELFSVRVQMEELGKlkarieaENRALILRDKDNTQRFLEE 2233
Cdd:pfam05483  511 MTLELK--KHQEDIINCKKQeeRMLKQIENLEEKEMNLRDELESVREEFIQKGD-------EVKCKLDKSEENARSIEYE 581
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2234 EAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ---EATRLKAEAELLQQQKELAQEQARR 2310
Cdd:pfam05483  582 VLKKEKQMKILENKCNNLKKQIENKNKNIEELHQENKALKKKGSAENKQLNAyeiKVNKLELELASAKQKFEEIIDNYQK 661
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2311 LQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSaeaERLKLRMAEMSraqARAEEDAQRFRKQAEEIGEKLHRTELATQ 2390
Cdd:pfam05483  662 EIEDKKISEEKLLEEVEKAKAIADEAVKLQKEID---KRCQHKIAEMV---ALMEKHKHQYDKIIEERDSELGLYKNKEQ 735
                          730       740       750       760
                   ....*....|....*....|....*....|....*....|..
gi 254675251  2391 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAK 2432
Cdd:pfam05483  736 EQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAK 777
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
1691-1882 5.41e-06

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 52.12  E-value: 5.41e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1691 EQQRQLLEEELAR-LQHEATAATQKRQELEAELAKVRAEmevllasKARAEEESRSTSEKSKQRLEAEAGRFR----ELA 1765
Cdd:PRK09510   78 EEQRKKKEQQQAEeLQQKQAAEQERLKQLEKERLAAQEQ-------KKQAEEAAKQAALKQKQAEEAAAKAAAaakaKAE 150
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1766 EEAARLRALAEEAKRQRQLAEEDAARQRAEAE-RVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAfqrrr 1844
Cdd:PRK09510  151 AEAKRAAAAAKKAAAEAKKKAEAEAAKKAAAEaKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAAEAKA----- 225
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 254675251 1845 LEEQAALHKADIEERLAQLRKASESELERQKGLVEDTL 1882
Cdd:PRK09510  226 AAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEVDDLF 263
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
2129-2584 5.58e-06

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 52.73  E-value: 5.58e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2129 DAEMEKHKKFAEQTLRQKAQVEQELTTLRLQLEE-TDHQKSILDE-ELQRLKAEVTEAAR-----QRSQVEEELFSVRVQ 2201
Cdd:PRK02224  257 EAEIEDLRETIAETEREREELAEEVRDLRERLEElEEERDDLLAEaGLDDADAEAVEARReeledRDEELRDRLEECRVA 336
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2202 MEELGK----LKARI-EAENRALILRDKDNTqrfLEEEAEKMK-QVAEEAARLSVAAQEAARLRQL---AEEDLAQQRAL 2272
Cdd:PRK02224  337 AQAHNEeaesLREDAdDLEERAEELREEAAE---LESELEEAReAVEDRREEIEELEEEIEELRERfgdAPVDLGNAEDF 413
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2273 AEKMLKEKMQAVQEATRLKAEaelLQQQKELAQEQARRLQEDKEQMAQQLVEETqGFQRTLEAERQRQLEMSAEAERLKL 2352
Cdd:PRK02224  414 LEELREERDELREREAELEAT---LRTARERVEEAEALLEAGKCPECGQPVEGS-PHVETIEEDRERVEELEAELEDLEE 489
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2353 RMAEMSRAQARAEE------DAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEK 2426
Cdd:PRK02224  490 EVEEVEERLERAEDlveaedRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEE 569
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2427 LKQEAKLLQLKSEEM-QTVQQEQILQETQALQKSFLSEKDSLL-QRERFIEQEKAKLEQLFQDEVAKAKQLREEQQrqqq 2504
Cdd:PRK02224  570 AREEVAELNSKLAELkERIESLERIRTLLAAIADAEDEIERLReKREALAELNDERRERLAEKRERKRELEAEFDE---- 645
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2505 qmeqekqelmASMEEARRRQREAEE------GVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALA-HS 2577
Cdd:PRK02224  646 ----------ARIEEAREDKERAEEyleqveEKLDELREERDDLQAEIGAVENELEELEELRERREALENRVEALEAlYD 715

                  ....*..
gi 254675251 2578 EIATTQA 2584
Cdd:PRK02224  716 EAEELES 722
PLEC smart00250
Plectin repeat;
3426-3462 6.52e-06

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 45.55  E-value: 6.52e-06
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3426 IRLLEAQVATGGIIDPVHSHRLPVDVAYQRGYFDEEM 3462
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
2215-2491 6.66e-06

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 52.66  E-value: 6.66e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2215 ENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEA 2294
Cdd:TIGR00618  163 KEKKELLMNLFPLDQYTQLALMEFAKKKSLHGKAELLTLRSQLLTLCTPCMPDTYHERKQVLEKELKHLREALQQTQQSH 242
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2295 ELLQQQKELAQEQARRLQEDKEQMAQqlvEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQ 2374
Cdd:TIGR00618  243 AYLTQKREAQEEQLKKQQLLKQLRAR---IEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSK 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2375 AEEIGEKLHRT------ELATQEKVTLVQTLEIQ----RQQSDHDAER---------LREAIAELEREKEKLKQeakLLQ 2435
Cdd:TIGR00618  320 MRSRAKLLMKRaahvkqQSSIEEQRRLLQTLHSQeihiRDAHEVATSIreiscqqhtLTQHIHTLQQQKTTLTQ---KLQ 396
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251  2436 LKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAK 2491
Cdd:TIGR00618  397 SLCKELDILQREQATIDTRTSAFRDLQGQLAHAKKQQELQQRYAELCAAAITCTAQ 452
SPEC smart00150
Spectrin repeats;
584-676 6.76e-06

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 47.71  E-value: 6.76e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    584 HGFVAAATKELMWLNEKEEEEVGFDWSDRNTNMAAKKESYSALMRELEMKEKKIKEIQNTGDRLLREDHPARPTVESFQA 663
Cdd:smart00150    1 QQFLRDADELEAWLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLIEEGHPDAEEIEERLE 80
                            90
                    ....*....|...
gi 254675251    664 ALQTQWSWMLQLC 676
Cdd:smart00150   81 ELNERWEELKELA 93
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 ...
1068-1842 6.85e-06

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 substr. MG1655 [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 225638 [Multi-domain]  Cd Length: 1480  Bit Score: 52.58  E-value: 6.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1068 EVLKTHEEQLKEAQAVPATLQELEATKASLKKLRAQAEAQQPVFNTLRDELRgAQEVGERLQQRHGERDVEVERWRERVT 1147
Cdd:COG3096   294 ELYTSRQQLAAEQYRHVDMSRELAELNGAEGDLEADYQAASDHLNLVQTALR-QQEKIERYQADLEELTIRLEEQNEVVE 372
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1148 QLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADplsAWLQDAKRRQEQIQAVPIAN--CQAAREQLRQEKALLEEIER 1225
Cdd:COG3096   373 EANERQEENEARAEAAELEVDELKSQLADYQQALD---VQQTRAIQYQQAIAALERAKelCHLPDLTADSAEEWLETFQA 449
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1226 HGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSqyikfiset 1305
Cdd:COG3096   450 KEEEATEKLLSLEQKMSMAQAAHSQFEQAYQLVVAIAGELARSEAWDVARELLREGPDQRHLAEQVQPLRM--------- 520
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1306 lRRMEEEERLAEQQRAEererlaeveaalekqRQLAEAHAQAKAQAELEAQELQRRMQ----EEVARREEAAVDAQQQKR 1381
Cdd:COG3096   521 -RLSELEQRLRQQQSAE---------------RLLADFCKRQGKNLDAEELEALHQELealiESLSDSVSNAREQRMALR 584
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1382 SIQEELQHLRQSSEAE----IQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRggaegelqALRARAEEAEAQKRQA 1457
Cdd:COG3096   585 QEQEQLQSRIQSLMQRapvwLAAQNALEQLSEQSGEEFTDSQDVTEYMQQLLERER--------EATVERDELGARKNAL 656
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1458 QEEAERLRRQVQDESQR-KRQAE-------AEL-------------ALR-------VKAEAEAAREKQRAL--------- 1500
Cdd:COG3096   657 DEEIERLSQPGGSEDQRlNALAErfggvllSEIyddvtiedapyfsALYgpsrhaiVVPDLSQVKEHLEGLtdcpedlyl 736
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1501 -----QALDELRLQAEEAERRL------RQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVA 1569
Cdd:COG3096   737 iegdpQSFDDSVFSVDELEKAVvvkiadRQWRYSRFPEIPLFGRAAREQRLESLHAERDVLSERHATLSFDVQKTQRLHQ 816
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1570 QLREEAERRAQQQAEAERAREEAERELERWQLK--------ANEALRLRLQA--------EEVAQQKSLAQADAEKQKEE 1633
Cdd:COG3096   817 AFSRFIGSHLAVAFEADPEAEIRQLNSRRNELEralsnhenDNQQQRIQFDQakegvtalNRLIPQLNLLADESLADRVE 896
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1634 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQ 1713
Cdd:COG3096   897 EIRERLDEAQEAARFIQQHGNTLSKLEPIASVLQSDPEQFEQLKEDYAQAQQMQRQARQQAFALTEVVQRRAHFSYSDSA 976
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1714 KRQELEAELA-KVRAEMEVLLASKARAEEESRSTSEKSKQ------RLEAEAGRFRELAEEAarLRALAEEAKRQRQLAE 1786
Cdd:COG3096   977 EMLSENSDLNeKLRQRLEQAEAERTRAREQLRQHQAQLSQynqvlaSLKSSYDTKKELLNEL--QQELQDIGVRADSGAE 1054
                         810       820       830       840       850
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251 1787 EDAARQRAEAERVLTEklaaiSEATRLKTEAEIALKEKEAEN--ERLRRLAEDEAFQR 1842
Cdd:COG3096  1055 ERARIRRDELHAQLST-----NRSRRNQLEKQLTFCEAEMDNltRKLRKLERDYFEMR 1107
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
2228-2537 6.89e-06

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 51.45  E-value: 6.89e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2228 QRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQ 2307
Cdd:pfam13868   34 IKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKQYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQEE 113
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2308 ARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERlklRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2387
Cdd:pfam13868  114 DQAEAEEKLEKQRQLREEIDEFNEEQAKWKELEKEEEKEEDL---RILEYLKEKAEREEEREAERREIKEEKEREIARLR 190
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2388 ATQEKvtlvqTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLksEEMQTVQQEQILQETQALQKsflsekdsL 2467
Cdd:pfam13868  191 AQQEK-----AQDEKAERDELRAKLYQEEQERKWRQKEREEAEKKARQR--QELQQAREEQIELKERRLAE--------E 255
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2468 LQRERfieQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRKQEE 2537
Cdd:pfam13868  256 AEREE---EEFERMLRKQAEDEEIEQEEAEKRREKRLEHRRELEKQIEERERQRAAEREEELEEGERLRE 322
CH_FLNA_rpt2 cd21312
second calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins; ...
122-229 7.18e-06

second calponin homology (CH) domain found in filamin-A (FLN-A) and similar proteins; Filamin-A (FLN-A) is also called actin-binding protein 280 (ABP-280), alpha-filamin, endothelial actin-binding protein, filamin-1, or non-muscle filamin. It promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. It also anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. FLN-A contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409161  Cd Length: 114  Bit Score: 47.88  E-value: 7.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  122 QSEDMTAKEKLLLWSQRMVEGyqgLRCDNFTTSWRDGRLFNAIIHRHKPMLI-DMNKVYRQTNLENLDQAFSVAERDLGV 200
Cdd:cd21312     7 EAKKQTPKQRLLGWIQNKLPQ---LPITNFSRDWQSGRALGALVDSCAPGLCpDWDSWDASKPVTNAREAMQQADDWLGI 83
                          90       100
                  ....*....|....*....|....*....
gi 254675251  201 TRLLDPEDVDVPQPDEKSIITYVSSLYDA 229
Cdd:cd21312    84 PQVITPEEIVDPNVDEHSVMTYLSQFPKA 112
AtpF COG0711
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion];
1299-1412 7.43e-06

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion];


Pssm-ID: 223783 [Multi-domain]  Cd Length: 161  Bit Score: 49.22  E-value: 7.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1299 IKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAvdAQ 1377
Cdd:COG0711    32 LKALDERQAKIADDLAEAERLKEEAQALLAEYEQELEEaREQASEIIEQAKKEAEQIAEEIKAEAEEELERIKEAA--EA 109
                          90       100       110
                  ....*....|....*....|....*....|....*
gi 254675251 1378 QQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSR 1412
Cdd:COG0711   110 EIEAEKERALEELRAEVAELAVAIAEKLLGKKVDE 144
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The ...
2231-2593 7.54e-06

RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 52.67  E-value: 7.54e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2231 LEEEAEKMKQVAEEAARLSVAAQEaaRLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARR 2310
Cdd:pfam02463  171 KKEALKKLIEETENLAELIIDLEE--LKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRD 248
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2311 LQEDKEQMAQQLVEETQgfqrtLEAERQRQLEMSAEAERLKLrmaemsraqaraEEDAQRFRKQAEEIGEKLHRtELATQ 2390
Cdd:pfam02463  249 EQEEIESSKQEIEKEEE-----KLAQVLKENKEEEKEKKLQE------------EELKLLAKEEEELKSELLKL-ERRKV 310
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2391 EKVTLVQTLEIQRQQSDHDAERLREAIAELEREKeKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQR 2470
Cdd:pfam02463  311 DDEEKLKESEKEKKKAEKELKKEKEEIEELEKEL-KELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSA 389
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2471 ERFIEQEKAKLEQLFQdevaKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEGVR-RKQEELQHLEQQRQQQE 2549
Cdd:pfam02463  390 AKLKEEELELKSEEEK----EAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTeEKEELEKQELKLLKDEL 465
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....
gi 254675251  2550 KLLAEENQRLRERLQRLEEEHRAALAHSEIATTQAASTKALPNG 2593
Cdd:pfam02463  466 ELKKSEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSGL 509
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
1616-1937 7.59e-06

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 380155 [Multi-domain]  Cd Length: 1848  Bit Score: 52.53  E-value: 7.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1616 VAQQKSLAQADA--EKQKEEAEREARRRGKAEEQAVRQRelaeQELEKQRQLAEGTAQQrlaAEQELIRLRAETEQGEQQ 1693
Cdd:NF012221 1535 VATSESSQQADAvsKHAKQDDAAQNALADKERAEADRQR----LEQEKQQQLAAISGSQ---SQLESTDQNALETNGQAQ 1607
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1694 RQLLEEELARLQHEATAATQKRQELEAELAKV-------RAEMEVLLasKARAEEESRSTSEKSKQRLEAEAGRF----R 1762
Cdd:NF012221 1608 RDAILEESRAVTKELTTLAQGLDALDSQATYAgesgdqwRNPFAGGL--LDRVQEQLDDAKKISGKQLADAKQRHvdnqQ 1685
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1763 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQR 1842
Cdd:NF012221 1686 KVKDAVAKSEAGVAQGEQNQANAEQDIDDAKADAEKRKDDALAKQNEAQQAESDANAAANDAQSRGEQDASAAENKANQA 1765
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1843 RRLEEQAALHKADIEERlaqlRKASESELERQKGLVEDtlrqrrqVEEEIMALKVSFEKAAAGKaelelelgrirsNAED 1922
Cdd:NF012221 1766 QADAKGAKQDESDKPNR----QGAAGSGLSGKAYSVEG-------VAEPGSHINPDSPAAADGR------------FSEG 1822
                         330
                  ....*....|....*
gi 254675251 1923 tMRSKEQAELEAARQ 1937
Cdd:NF012221 1823 -LTEQEQEALEGATN 1836
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1304-1464 7.83e-06

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 51.49  E-value: 7.83e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1304 ETLRRMEEEERLAEQQRAEERErlAEVEAALEKQRQLAEAHAQAKAQAEleaqelQRRMQEEVARREEAAVDAQQQKRSI 1383
Cdd:COG3064   115 EQQKQAEEAEKQAQLEQKQQEE--QARKAAAEQKKKAEAAKAKAAAEAA------KLKAAAEAKKKAEEAAKAAEEAKAK 186
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1384 QEELQhlrQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAER 1463
Cdd:COG3064   187 AEAAA---AKKKAEAEAKAAAEKAKAEAEAKAKAEKKAEAAAEEKAAAEKKKAAAKAKADKAAAAAKAAERKAAAAALDD 263

                  .
gi 254675251 1464 L 1464
Cdd:COG3064   264 I 264
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1608-1790 9.16e-06

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 51.49  E-value: 9.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1608 RLRLQAEEVaQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRlaAEQELIRLRAET 1687
Cdd:COG3064    84 KEEQVAEEL-KPKQAAEQERLKQLEKERLKAQEQQKQAEEAEKQAQLEQKQQEEQARKAAAEQKKK--AEAAKAKAAAEA 160
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1688 EQGEQQRQllEEELARLQHEATAATQKRQELEAELAKVRAEMEvLLASKARAEEESRSTSEKSKQRL-EAEAGRFRELAE 1766
Cdd:COG3064   161 AKLKAAAE--AKKKAEEAAKAAEEAKAKAEAAAAKKKAEAEAK-AAAEKAKAEAEAKAKAEKKAEAAaEEKAAAEKKKAA 237
                         170       180
                  ....*....|....*....|....
gi 254675251 1767 EAARLRALAEEAKRQRQLAEEDAA 1790
Cdd:COG3064   238 AKAKADKAAAAAKAAERKAAAAAL 261
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
1448-1820 9.30e-06

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 434873 [Multi-domain]  Cd Length: 521  Bit Score: 51.87  E-value: 9.30e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1448 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQ 1527
Cdd:pfam15709  162 QETPASISHERELIDKAKRRKGTKTDKTKTPKREREGKVHGEAEAAVGKSRESKAEKKSELISKGKKTGAKRKRTQKERN 241
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1528 VQVALETA----QRSAEVELQSKRASFAEKTAQLERTLQeeHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKA 1603
Cdd:pfam15709  242 LEVAAELSgpdvINSKETEDASERGAFSSDSVVEDPWLS--SKYDAEESQVSIDGRSSPTQTFVVTGNMESEEERSEEDP 319
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1604 NEALRLRLQAEEVAQQKslaqADAEKQKEEAEREARRRGKAEEQAVRQRElaEQELEKQRQLAEGTAQQRLAAEqelIRL 1683
Cdd:pfam15709  320 SKALLEKREQEKASRDR----LRAERAEMRRLEVERKRREQEEQRRLQQE--QLERAEKMREELELEQQRRFEE---IRL 390
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1684 RAETEQGEQQRQLLEEELARLQHEAtAATQKRQELEAELAKVRAemevlLASKARAEEESRSTSEKSKQRLEAEagrfrE 1763
Cdd:pfam15709  391 RKQRLEEERQRQEEEERKQRLQLQA-AQERARQQQEEFRRKLQE-----LQRKKQQEEAERAEAEKQRQKELEM-----Q 459
                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675251  1764 LAEEAARLRALAEEAK----RQRQLAEEdAARQRAEAERVLTEKLAAISEATRLKTEAEIA 1820
Cdd:pfam15709  460 LAEEQKRLMEMAEEERleyqRQKQEAEE-KARLEAEERRQKEEEAARLALEEAMKQAQEQA 519
mukB PRK04863
chromosome partition protein MukB;
2144-2429 9.67e-06

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 52.27  E-value: 9.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2144 RQKAQVEQELTTLRLQLeeTDHQKSiLDEE-------------LQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKlkA 2210
Cdd:PRK04863  383 ARAEAAEEEVDELKSQL--ADYQQA-LDVQqtraiqyqqavqaLERAKQLCGLPDLTADNAEDWLEEFQAKEQEATE--E 457
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2211 RIEAENRaliLRDKDNTQRFLEEEAEKMKQVAEEaarlsVAAQEAARLRQLAEEDLAQQRALAEKM---------LKEKM 2281
Cdd:PRK04863  458 LLSLEQK---LSVAQAAHSQFEQAYQLVRKIAGE-----VSRSEAWDVARELLRRLREQRHLAEQLqqlrmrlseLEQRL 529
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2282 QAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEEtqgfqrtLEAERQRQLEMSAEAERLKLRMAE-MSRA 2360
Cdd:PRK04863  530 RQQQRAERLLAEFCKRLGKNLDDEDELEQLQEELEARLESLSES-------VSEARERRMALRQQLEQLQARIQRlAARA 602
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251 2361 QA--RAEEDAQRFRKQAEEigeklhrtELATQEKVT--LVQTLEIQRQQSDHDaERLREAIAELEREKEKLKQ 2429
Cdd:PRK04863  603 PAwlAAQDALARLREQSGE--------EFEDSQDVTeyMQQLLERERELTVER-DELAARKQALDEEIERLSQ 666
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
1675-1770 1.05e-05

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 51.88  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1675 AAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLlasKARAEEESRSTSEKSKQRL 1754
Cdd:PRK11448  146 ALQQEVLTLKQQLELQAREKAQSQALAEAQQQELVALEGLAAELEEKQQELEAQLEQL---QEKAAETSQERKQKRKEIT 222
                          90
                  ....*....|....*.
gi 254675251 1755 EAEAGRFrELAEEAAR 1770
Cdd:PRK11448  223 DQAAKRL-ELSEEETR 237
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1514-1785 1.12e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227278 [Multi-domain]  Cd Length: 420  Bit Score: 51.26  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1514 ERRLRQAEAERARQVQVALETAQRSAEveLQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAE 1593
Cdd:COG4942    37 DKQLKQIQKEIAALEKKIREQQDQRAK--LEKQLKSLETEIASLEAQLIETADDLKKLRKQIADLNARLNALEVQEREQR 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1594 RELER-----WQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEG 1668
Cdd:COG4942   115 RRLAEqlaalQRSGRNPPPALLVSPEDAQRSVRLAIYYGALNPARAERIDALKATLKQLAAVRAEIAAEQAELTTLLSEQ 194
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1669 TAQQRlaAEQELIRLRAETEQG-EQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEvllasKARAEEESRSTS 1747
Cdd:COG4942   195 RAQQA--KLAQLLEERKKTLAQlNSELSADQKKLEELRANESRLKNEIASAEAAAAKAREAAA-----AAEAAAARARAA 267
                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 254675251 1748 EKSKqrleaEAGRFRELAEEAARLRALAEEAKRQRQLA 1785
Cdd:COG4942   268 EAKR-----TGETYKPTAPEKMLISSTGGFGALRGQLA 300
COG4487 COG4487
Uncharacterized protein, contains DUF2130 domain [Function unknown];
1612-1806 1.14e-05

Uncharacterized protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 226889 [Multi-domain]  Cd Length: 438  Bit Score: 51.36  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1612 QAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGE 1691
Cdd:COG4487    31 QIEQEDQSRILNTLEEFEKEANEKRAQYRSAKKKELSQLEEQLINQKKEQKNLFNEQIKQFELALQDEIAKLEALELLNL 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1692 QQ---RQLLEEELARLQHEATAATQKRQELEaELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAG----RFREL 1764
Cdd:COG4487   111 EKdkeLELLEKELDELSKELQKQLQNTAEII-EKKRENNKNEERLKFENEKKLEESLELEREKFEEQLHEAnldlEFKEN 189
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 254675251 1765 AEEAARLRALAEEAKRqrqLAEEDAARQRAEAERVLTEKLAA 1806
Cdd:COG4487   190 EEQRESKWAILKKLKR---RAELGSQQVQGEALELPNESFIR 228
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
1450-1660 1.21e-05

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 50.96  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1450 AEAQKRQAQEEAERLRRQVQDESQRKRQAEaELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQ 1529
Cdd:PRK09510   61 VEQYNRQQQQQKSAKRAEEQRKKKEQQQAE-ELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEEAAA 139
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1530 VALETAQRSAEVElqSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEaerelerwqlKANEALRL 1609
Cdd:PRK09510  140 KAAAAAKAKAEAE--AKRAAAAAKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEA----------KKKAEAEA 207
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 254675251 1610 RLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1660
Cdd:PRK09510  208 KKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAE 258
CH_NAV2 cd21285
calponin homology (CH) domain found in neuron navigator 2; Neuron navigator 2 (NAV2), also ...
9-108 1.56e-05

calponin homology (CH) domain found in neuron navigator 2; Neuron navigator 2 (NAV2), also called helicase APC down-regulated 1 (HELAD1), pore membrane and/or filament-interacting-like protein 2 (POMFIL2), retinoic acid inducible in neuroblastoma 1 (RAINB1), Steerin-2 (STEERIN2), or Unc-53 homolog 2 (unc53H2), possesses 3' to 5' helicase activity and exonuclease activity. It is involved in neuronal development, specifically in the development of different sensory organs. NAV2 contains a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409134  Cd Length: 121  Bit Score: 47.27  E-value: 1.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    9 DRVQKKTFTKWVNKHLIKA--QRHISDLYEDLRDGHNLISLLEVLSGDSLPREKG--RMRFHKLQNVQIALDYLRHRQVK 84
Cdd:cd21285     8 NGFDKQIYTDWANHYLAKSghKRLIKDLQQDVTDGVLLAEIIQVVANEKIEDINGcpKNRSQMIENIDACLSFLAAKGIN 87
                          90       100
                  ....*....|....*....|....
gi 254675251   85 LVNIRNDDIADGNPKLTLGLIWTI 108
Cdd:cd21285    88 IQGLSAEEIRNGNLKAILGLFFSL 111
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
2123-2303 1.60e-05

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 50.72  E-value: 1.60e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2123 KQKQAADAEMEKHKKFAEQTlRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEElfsVRVQM 2202
Cdd:COG3064    82 KKKEEQVAEELKPKQAAEQE-RLKQLEKERLKAQEQQKQAEEAEKQAQLEQKQQEEQARKAAAEQKKKAEAA---KAKAA 157
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2203 EELGKLKARIEAENRA-LILRDKDNTQRFLEEEAEKMKQVAEEAARLSVA--AQEAARLRQLAEEDLAQQRALAEKMLKE 2279
Cdd:COG3064   158 AEAAKLKAAAEAKKKAeEAAKAAEEAKAKAEAAAAKKKAEAEAKAAAEKAkaEAEAKAKAEKKAEAAAEEKAAAEKKKAA 237
                         170       180
                  ....*....|....*....|....
gi 254675251 2280 KMQAVQEATRLKAEAELLQQQKEL 2303
Cdd:COG3064   238 AKAKADKAAAAAKAAERKAAAAAL 261
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
915-1528 1.63e-05

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 51.19  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  915 DRLVAEREYGSCSRhyQQLLQSLEQGEQEESRCQRCISELKDIRLQLEACETrtvhrlrlplDKDPAREcaqRIAEQQKA 994
Cdd:PRK02224  223 ERYEEQREQARETR--DEADEVLEEHEERREELETLEAEIEDLRETIAETER----------EREELAE---EVRDLRER 287
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  995 ----QAEVEGLGKGVARLSAEAEKVLALPEpspaapTLRSELELTLGKLEQVRSlsaiyleklkTISLVIRSTQGAEEVL 1070
Cdd:PRK02224  288 leelEEERDDLLAEAGLDDADAEAVEARRE------ELEDRDEELRDRLEECRV----------AAQAHNEEAESLREDA 351
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1071 KTHEEQLKEAQAVPATLQ-ELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRERVTql 1149
Cdd:PRK02224  352 DDLEERAEELREEAAELEsELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELREREA-- 429
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1150 lerwqavlaqtdvrqrELEqlgrqlryyresadplsawlqdakrrqeqiqavpiANCQAAREQLRQEKALLEEierhgEK 1229
Cdd:PRK02224  430 ----------------ELE-----------------------------------ATLRTARERVEEAEALLEA-----GK 453
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1230 VEECQKFAKQ--YINAIKDYELQLITYKAQLEPVASpakkpkvqsgsesviqEYVDLRTRYSELTTLTSQyikfiSETLR 1307
Cdd:PRK02224  454 CPECGQPVEGspHVETIEEDRERVEELEAELEDLEE----------------EVEEVEERLERAEDLVEA-----EDRIE 512
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1308 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEevARREEAAVDAQQQkrSIQEEL 1387
Cdd:PRK02224  513 RLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEE--AREEVAELNSKLA--ELKERI 588
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1388 QHLR--QSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQAlrARAEEAEAQKRQAQEEAErlr 1465
Cdd:PRK02224  589 ESLEriRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEFDE--ARIEEAREDKERAEEYLE--- 663
                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251 1466 rQVQDESQRKRQAEAELALRVKA------EAEAAREKQRAL----QALDELRLQAEEAERRLRQAEAE-RARQV 1528
Cdd:PRK02224  664 -QVEEKLDELREERDDLQAEIGAveneleELEELRERREALenrvEALEALYDEAEELESMYGDLRAElRQRNV 736
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
2146-2571 1.77e-05

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 51.26  E-value: 1.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2146 KAQVEQELTTLRLQLEETDHQKSILDEELQRlkaEVTEAARQRSQVEEELFSVRVQMEELGKLKAriEAENRALILRDKD 2225
Cdd:pfam05483  203 RVQAENARLEMHFKLKEDHEKIQHLEEEYKK---EINDKEKQVSLLLIQITEKENKMKDLTFLLE--ESRDKANQLEEKT 277
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2226 NTQ-RFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ---- 2300
Cdd:pfam05483  278 KLQdENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEfeat 357
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2301 ----KELAQEQARRLQEDKEQMaQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEmsraqaraEEDAQRFRKQAE 2376
Cdd:pfam05483  358 tcslEELLRTEQQRLEKNEDQL-KIITMELQKKSSELEEMTKFKNNKEVELEELKKILAE--------DEKLLDEKKQFE 428
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2377 EIGEKLHRTElatQEKVTLVQTleiqRQQSDHDAERLREAIAELE----REKEKLKQEAKLLQLKSEEMQTVQQEQILQE 2452
Cdd:pfam05483  429 KIAEELKGKE---QELIFLLQA----REKEIHDLEIQLTAIKTSEehylKEVEDLKTELEKEKLKNIELTAHCDKLLLEN 501
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2453 TQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQqqmeqEKQELMASMEEARRRQREAEEGVR 2532
Cdd:pfam05483  502 KELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELES-----VREEFIQKGDEVKCKLDKSEENAR 576
                          410       420       430
                   ....*....|....*....|....*....|....*....
gi 254675251  2533 RKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEHR 2571
Cdd:pfam05483  577 SIEYEVLKKEKQMKILENKCNNLKKQIENKNKNIEELHQ 615
PLEC smart00250
Plectin repeat;
3058-3094 1.81e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 44.40  E-value: 1.81e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3058 KLLSAEKAVTGYRDPYSGQSVSLFQALKKGLIPREQG 3094
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The ...
1914-2579 1.83e-05

RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 51.13  E-value: 1.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1914 GRIRSNAEDTMRSKEQAELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERA 1993
Cdd:pfam02463  142 GKIEIIAMMKPERRLEIEEEAAGSRLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLEL 221
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1994 EQEsaRQLQLAQEAAQKRLQAEEKAHAFVVQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSR 2073
Cdd:pfam02463  222 EEE--YLLYLDYLKLNEERIDLLQELLRDEQEEIESSKQEIEKEEEKLAQVLKENKEEEKEKKLQEEELKLLAKEEEELK 299
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2074 KQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQEL 2153
Cdd:pfam02463  300 SELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKK 379
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2154 TTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQM--EELGKLKARIEAENRALILRDKDNTQRFL 2231
Cdd:pfam02463  380 KLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEEleILEEEEESIELKQGKLTEEKEELEKQELK 459
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2232 EEEAEKM-KQVAEEAARLSVAA----QEAARLRQLAEEDLAQQRA--------LAEKMLKEKMQAVQEATRLKAEAELLQ 2298
Cdd:pfam02463  460 LLKDELElKKSEDLLKETQLVKlqeqLELLLSRQKLEERSQKESKarsglkvlLALIKDGVGGRIISAHGRLGDLGVAVE 539
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2299 QQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEI 2378
Cdd:pfam02463  540 NYKVAISTAVIVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDD 619
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2379 GEKLHRTELATQEKVTLVQTLEIQRQQsdhdaeRLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQK 2458
Cdd:pfam02463  620 KRAKVVEGILKDTELTKLKESAKAKES------GLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEE 693
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2459 SFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEgvRRKQEEL 2538
Cdd:pfam02463  694 ILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEE--EKSELSL 771
                          650       660       670       680
                   ....*....|....*....|....*....|....*....|.
gi 254675251  2539 QHLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSEI 2579
Cdd:pfam02463  772 KEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKE 812
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
1540-2472 1.94e-05

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 435022 [Multi-domain]  Cd Length: 1112  Bit Score: 51.26  E-value: 1.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1540 EVELQSKRASFAEKTAQ-LERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELerwQLKANEALRLRLQAEEVAQ 1618
Cdd:pfam15921   58 EVELDSPRKIIPYPGKEhIERVLEEYSHQVKDLQRRLNESNELHEKQKFYLRQSVIDL---QTKLQEMQMERDAMADIRR 134
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1619 QKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQqrlaaeqELIRLRAETEQGEQQRQLLE 1698
Cdd:pfam15921  135 RESQSQEDLRNQLQNTVHELEAAKCLKEDMLNDSNTQIEQLRKMMLSHEGVLQ-------EIRSILVDFEEASGKKIYEH 207
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1699 EELARLQHEA--TAATQKRQELEAELA-------KVRAEMEVLLA-SKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1768
Cdd:pfam15921  208 DSMSTIHFRSlgSAISKILRELDTEISylkgrifPVEDQLEALKSeSQNKIELLLQQHQDRIEQLISEHEVEITGLTEKA 287
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1769 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQ 1848
Cdd:pfam15921  288 SSARSQANSIQSQLEIIQEQARNQNSMYMRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQ 367
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1849 AALHKADIEERLAQL-----RKASESELERQkglvedtlrQRRQVEEEIMALKVSFEKAAAGKAELELELGRIRSNAEdT 1923
Cdd:pfam15921  368 FSQESGNLDDQLQKLladlhKREKELSLEKE---------QNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEALLK-A 437
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1924 MRSKEQAELEaarqRQLAaeeeqrrreaeervqrslaaeeeAARQRKVALEEVERLKAKVEEARR-LRERAEQESARQLQ 2002
Cdd:pfam15921  438 MKSECQGQME----RQMA-----------------------AIQGKNESLEKVSSLTAQLESTKEmLRKVVEELTAKKMT 490
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2003 LAQE---------AAQKRLQAEEKAHAFV--VQQREEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREaaq 2071
Cdd:pfam15921  491 LESSertvsdltaSLQEKERAIEATNAEItkLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMAEKDKVIEIL--- 567
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2072 sRKQVEEAERLkqsaeeqaqaqaqaqaaaeklrkeaeqeaarraqaeqaalkqkqaadaeMEKHKKFAEQTLRQKAQVEQ 2151
Cdd:pfam15921  568 -RQQIENMTQL-------------------------------------------------VGQHGRTAGAMQVEKAQLEK 597
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2152 ELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQV----EEELFSVRVQMEELGKLKARIE---------AENRA 2218
Cdd:pfam15921  598 EINDRRLELQEFKILKDKKDAKIRELEARVSDLELEKVKLvnagSERLRAVKDIKQERDQLLNEVKtsrnelnslSEDYE 677
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2219 LILRDKDNTQRFLEEEAEKMK------QVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEK----MLKEKMQAVQEA- 2287
Cdd:pfam15921  678 VLKRNFRNKSEEMETTTNKLKmqlksaQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRgqidALQSKIQFLEEAm 757
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2288 TRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLvEETQGFQRTLeaeRQRQLEMSAEAERLKLRMAEMSRAQARAEED 2367
Cdd:pfam15921  758 TNANKEKHFLKEEKNKLSQELSTVATEKNKMAGEL-EVLRSQERRL---KEKVANMEVALDKASLQFAECQDIIQRQEQE 833
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2368 AQRFRKQAEEIGEKLHRTELATQEKVT--LVQTLEIQRQQSD-HDAERLREAIAELEREKEKLKQEAK--LLQLKSEEMQ 2442
Cdd:pfam15921  834 SVRLKLQHTLDVKELQGPGYTSNSSVKprLLQPASFTRPHSNvPSSQSTASFLSHHSIKCEMLKEDPTrdLKQLLQELRS 913
                          970       980       990
                   ....*....|....*....|....*....|
gi 254675251  2443 TVQQEQILQETQALQKSFLSEKDSLLQRER 2472
Cdd:pfam15921  914 VINEEPNVKLSKAELVGRQTSLGALEDRVR 943
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
1122-1527 1.96e-05

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 51.20  E-value: 1.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1122 QEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLSAWLQDAKrrqeqiqav 1201
Cdd:TIGR00606  694 QEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQKVNRDIQRLK--------- 764
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1202 piancqaarEQLRQEKALLEEIERHGEKVEECQK---FAKQYINAIKDYELQLITYKAQLEPVASPAKKPKVQSGSESVI 1278
Cdd:TIGR00606  765 ---------NDIEEQETLLGTIMPEEESAKVCLTdvtIMERFQMELKDVERKIAQQAAKLQGSDLDRTVQQVNQEKQEKQ 835
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1279 QEYVDLRTRYSELTTLTSQYIKFISETLRRMEE--EERLAEQQRAEERERLAEVEAALEKQRQ-LAEAHAQAKAQAELEA 1355
Cdd:TIGR00606  836 HELDTVVSKIELNRKLIQDQQEQIQHLKSKTNElkSEKLQIGTNLQRRQQFEEQLVELSTEVQsLIREIKDAKEQDSPLE 915
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1356 Q---ELQRRMQEEVARREEAAVDAQQQKRSIQEELQHL------------------RQSSEAEIQAKAQQVEAAERSRMR 1414
Cdd:TIGR00606  916 TfleKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIhgymkdienkiqdgkddyLKQKETELNTVNAQLEECEKHQEK 995
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1415 IEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALrvkaeaeAAR 1494
Cdd:TIGR00606  996 INEDMRLMRQDIDTQKIQERWLQDNLTLRKRENELKEVEEELKQHLKEMGQMQVLQMKQEHQKLEENIDL-------IKR 1068
                          410       420       430
                   ....*....|....*....|....*....|...
gi 254675251  1495 EKQRALQALDELRLQAEEAERRLRQAEAERARQ 1527
Cdd:TIGR00606 1069 NHVLALGRQKGYEKEIKHFKKELREPQFRDAEE 1101
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
2073-2324 2.02e-05

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 50.79  E-value: 2.02e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2073 RKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKAQVEQE 2152
Cdd:COG4372    87 RTELGTAQGEKRAAETEREAARSELQKARQEREAVRQELAAARQNLAKAQQELARLTKQAQDLQTRLKTLAEQRRQLEAQ 166
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2153 LTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLe 2232
Cdd:COG4372   167 AQSLQASQKQLQASATQLKSQVLDLKLRSAQIEQEAQNLATRANAAQARTEELARRAAAAQQTAQAIQQRDAQISQKAQ- 245
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2233 EEAEKMKQVAEEAARLSVAAQEAARLRQLAEEdlAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQ 2312
Cdd:COG4372   246 QIAARAEQIRERERQLQRLETAQARLEQEVAQ--LEAYYQAYVRLRQQAAATQRGQVLAGAAQRVAQAQAQAQAQAQLLS 323
                         250
                  ....*....|..
gi 254675251 2313 EDKEQMAQQLVE 2324
Cdd:COG4372   324 SANRPAALRLRR 335
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3314-3352 2.02e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 44.25  E-value: 2.02e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3314 LLQGSGCLAGIYLEDSKEKVTIYEAMRRGLLRPSTATLL 3352
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
CH_PLS2_rpt1 cd21324
first calponin homology (CH) domain found in plastin-2; Plastin-2, also called L-plastin, or ...
12-119 2.18e-05

first calponin homology (CH) domain found in plastin-2; Plastin-2, also called L-plastin, or LC64P, or lymphocyte cytosolic protein 1 (LCP-1), is an actin-binding protein that plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-2 contains four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409173  Cd Length: 145  Bit Score: 47.31  E-value: 2.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   12 QKKTFTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR----EKGRMRFHKLQNVQIALDYL 78
Cdd:cd21324    25 EKYAFVNWINKalendpdckHVIPMNPNTDDLFKAVGDGIVLCKMINFSVPDTIDErtinKKKLTPFTIQENLNLALNSA 104
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 254675251   79 RHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQISDIQV 119
Cdd:cd21324   105 SAIGCHVVNIGAEDLKEGKPYLVLGLLWQVIKIGLFADIEL 145
HlyD pfam00529
HlyD membrane-fusion protein of T1SS; HlyD is a component of the prototypical alpha-haemolysin ...
1345-1502 2.28e-05

HlyD membrane-fusion protein of T1SS; HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD and HlyB are inner-membrane proteins and specific components of the transport apparatus of alpha-haemolysin. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 49.73  E-value: 2.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1345 AQAKAQAEL-EAQELQRRMQEEVARReEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAER--SRMRIEEEIRV 1421
Cdd:pfam00529   59 ALDSAEAQLaKAQAQVARLQAELDRL-QALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIdlARRRVLAPIGG 137
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1422 V-RLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKR-QAEAELALrvkAEAEAAREKQRA 1499
Cdd:pfam00529  138 IsRESLVTAGALVAQAQANLLATVAQLDQIYVQITQSAAENQAEVRSELSGAQLQIaEAEAELKL---AKLDLERTEIRA 214

                   ...
gi 254675251  1500 LQA 1502
Cdd:pfam00529  215 PVD 217
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
2170-2492 2.32e-05

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 227606 [Multi-domain]  Cd Length: 833  Bit Score: 50.79  E-value: 2.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2170 LDEELQRLKAEVTEAARQRSQVEEELFSVRVQME---ELGKLKARIEAENRALilrdkDNTQRFLEEEAEKMKQVAEEAA 2246
Cdd:COG5281   274 LNRQFHYLTAAQLEQIAALQRAGDTAAAAAAAAEaaaAMDDRTARVKENMGTL-----ETAWDALADAAKKMWDAVLGIG 348
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2247 RlsvaAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEaTRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEET 2326
Cdd:COG5281   349 R----EDKQAALLAAKLAAEKLARVTAQGALNARLKLAQD-DLTQAELNYAAADQAANQEGALNAREDEAEVLSTQEERR 423
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2327 QGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARA--EEDAQRFRKQAEEIGEKLHRTELATQEkvtLVQTLEIQRQ 2404
Cdd:COG5281   424 DILKNLLADAEKRTARQEELNKALAKAKILQADKAAKAyqEDILQREAQSRGKTAAAERSQEQMTAA---LKALLAFQQQ 500
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2405 QSDHDAERLREAiaelerekeklkqEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQL 2484
Cdd:COG5281   501 IADLSGAKEKAS-------------DQKSLLWKAEEQYALLKEEAKQRQLQEQKALLEHKKETLEYTSQLAELLDQQADR 567

                  ....*...
gi 254675251 2485 FQDEVAKA 2492
Cdd:COG5281   568 FELSAQAA 575
CH_PLS1_rpt3 cd21329
third calponin homology (CH) domain found in plastin-1; Plastin-1, also called ...
7-115 2.35e-05

third calponin homology (CH) domain found in plastin-1; Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. It contains four copies of the CH domain. This model corresponds to the third CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409178  Cd Length: 118  Bit Score: 46.52  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    7 ERDRVQKKTFTKWVNKhlIKAQRHISDLYEDLRDGHNLISLLEV---------LSGDSLPREKGRMRfhKLQNVQIALDY 77
Cdd:cd21329     2 EGESSEERTFRNWMNS--LGVNPYVNHLYSDLCDALVIFQLYEMtrvpvdwghVNKPPYPALGGNMK--KIENCNYAVEL 77
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 254675251   78 LRHR-QVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 115
Cdd:cd21329    78 GKNKaKFSLVGIAGSDLNEGNKTLTLALIWQLMRRYTLN 116
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
1542-1937 2.37e-05

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteristic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 50.07  E-value: 2.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1542 ELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKS 1621
Cdd:pfam19220   21 DLRSLKADFSQLIEPIEAILRELPQAKSRLLELEALLAQERAAYGKLRRELAGLTRRLSAAEGELEELVARLAKLEAALR 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1622 LAQADAEKQKEEAEREARRRGKAEEQ---AVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRaeteqgeQQRQLLE 1698
Cdd:pfam19220  101 EAEAAKEELRIELRDKTAQAEALERQlaaETEQNRALEEENKALREEAQAAEKALQRAEGELATAR-------ERLALLE 173
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1699 EELARLQH-------EATAATQKRQELEAELAKVRAEMEVLLASKAraeeESRSTSEKSKQRLEAEAGRFR-ELAEEAAR 1770
Cdd:pfam19220  174 QENRRLQAlseeqaaELAELTRRLAELETQLDATRARLRALEGQLA----AEQAERERAEAQLEEAVEAHRaERASLRMK 249
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1771 LRALAEEAKRQRQLAEEDAARQRaeaervltEKLAAISEATRLKTEAEIALKEKEAENERLRrlAEDEAFQRRRLEEQAA 1850
Cdd:pfam19220  250 LEALTARAAATEQLLAEARNQLR--------DRDEAIRAAERRLKEASIERDTLERRLAGLE--ADLERRTQQFQEMQRA 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1851 lhKADIEERLAQLRKA---SESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAG-KAELElelgrirsnAEDTMRS 1926
Cdd:pfam19220  320 --RAELEERAEMLTKAlaaKDAALERAEERIASLSDRIAELTKRFEVERAALEQANRRlKEELQ---------RERAERA 388
                          410
                   ....*....|.
gi 254675251  1927 KEQAELEAARQ 1937
Cdd:pfam19220  389 LAQGALEIARE 399
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1451-1745 2.41e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227278 [Multi-domain]  Cd Length: 420  Bit Score: 50.11  E-value: 2.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1451 EAQKRQAQEEAERLRRQVQDESQRKRQAEAELAlRVKAEAEAAREKQRALQA-LDELRLQAEEAERR---LRQAEAERAR 1526
Cdd:COG4942    37 DKQLKQIQKEIAALEKKIREQQDQRAKLEKQLK-SLETEIASLEAQLIETADdLKKLRKQIADLNARlnaLEVQEREQRR 115
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1527 QVQVALETAQRSAEVE-----LQSKRASFAEKTAQLERTLQEEhvtvaqlreeaerraqqqaeaerareeaerelerwql 1601
Cdd:COG4942   116 RLAEQLAALQRSGRNPppallVSPEDAQRSVRLAIYYGALNPA------------------------------------- 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1602 kanealRLRLQAEEVAQQKSLAqadaeKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELI 1681
Cdd:COG4942   159 ------RAERIDALKATLKQLA-----AVRAEIAAEQAELTTLLSEQRAQQAKLAQLLEERKKTLAQLNSELSADQKKLE 227
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251 1682 RLRAETEQgeqqrqlLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRS 1745
Cdd:COG4942   228 ELRANESR-------LKNEIASAEAAAAKAREAAAAAEAAAARARAAEAKRTGETYKPTAPEKM 284
PRK12704 PRK12704
phosphodiesterase; Provisional
2217-2413 2.46e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 50.55  E-value: 2.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2217 RALILRDKDNTQRFLEEEAEKMKQVAEEAarLSVAAQEAARLRQLAEEDLAQQRalaekmlkEKMQAVQEatRLKAEAEL 2296
Cdd:PRK12704   30 EAKIKEAEEEAKRILEEAKKEAEAIKKEA--LLEAKEEIHKLRNEFEKELRERR--------NELQKLEK--RLLQKEEN 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2297 LQQQKELAQEQARRLQEDKEQMAQQL--VEETQGFQRTLEAERQRQLE----MSAEAERLKLrmaeMSRAQARAEEDAQR 2370
Cdd:PRK12704   98 LDRKLELLEKREEELEKKEKELEQKQqeLEKKEEELEELIEEQLQELErisgLTAEEAKEIL----LEKVEEEARHEAAV 173
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 254675251 2371 FRKQAEEIGEklhrtELATQE-KVTLVQTleIQRQQSDHDAERL 2413
Cdd:PRK12704  174 LIKEIEEEAK-----EEADKKaKEILAQA--IQRCAADHVAETT 210
WEMBL pfam05701
Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required ...
1323-1837 2.53e-05

Weak chloroplast movement under blue light; WEMBL consists of several plant proteins required for the chloroplast avoidance response under high intensity blue light. This avoidance response consists in the relocation of chloroplasts on the anticlinal side of exposed cells. Acts in association with PMI2 to maintain the velocity of chloroplast photo-relocation movement via the regulation of cp-actin filaments. Thus several member-sequences are described as "myosin heavy chain-like".


Pssm-ID: 428594 [Multi-domain]  Cd Length: 562  Bit Score: 50.41  E-value: 2.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1323 ERERLAEVEAALEKQ-----RQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRsiQEELQHLRQ----- 1392
Cdd:pfam05701   35 ERRKLVELELEKVQEeipeyKKQSEAAEAAKAQVLEELESTKRLIEELKLNLERAQTEEAQAKQ--DSELAKLRVeemeq 112
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1393 --SSEAEIQAKAQqVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQd 1470
Cdd:pfam05701  113 giADEASVAAKAQ-LEVAKARHAAAVAELKSVKEELESLRKEYASLVSERDIAIKRAEEAVSASKEIEKTVEELTIELI- 190
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1471 esqrkrQAEAELALRVKAEAEAAREKQRALQALDELRL-------QAEEAERRLRQaEAERARQVQVALETAqrsaEVEL 1543
Cdd:pfam05701  191 ------ATKESLESAHAAHLEAEEHRIGAALAREQDKLnwekelkQAEEELQRLNQ-QLLSAKDLKSKLETA----SALL 259
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1544 QSKRASFAektAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERwqlKANEALRLRLQAEevaqqkSLa 1623
Cdd:pfam05701  260 LDLKAELA---AYMESKLKEEADGEGNEKKTSTSIQAALASAKKELEEVKANIEK---AKDEVNCLRVAAA------SL- 326
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1624 QADAEKQKeeaerearrrgkAEEQAVRQRELA--------EQELEKQRQLAEgTAQQRLAAEQE--------LIRLRAET 1687
Cdd:pfam05701  327 RSELEKEK------------AELASLRQREGMasiavsslEAELNRTKSEIA-LVQAKEKEAREkmvelpkqLQQAAQEA 393
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1688 EQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASK------ARAEEESRSTSEKSKQR-------L 1754
Cdd:pfam05701  394 EEAKSLAQAAREELRKAKEEAEQAKAAASTVESRLEAVLKEIEAAKASEklalaaIKALQESESSAESTNQEdsprgvtL 473
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1755 EAE-----AGRFRElAEEAARLRalAEEAKRQRQLAEEDAAR---QRAEAERVLTEKLAAISEATrlkTEAEIALKEKEA 1826
Cdd:pfam05701  474 SLEeyyelSKRAHE-AEELANKR--VAEAVSQIEEAKESELRsleKLEEVNREMEERKEALKIAL---EKAEKAKEGKLA 547
                          570
                   ....*....|.
gi 254675251  1827 ENERLRRLAED 1837
Cdd:pfam05701  548 AEQELRKWRAE 558
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
2127-2429 2.68e-05

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 227606 [Multi-domain]  Cd Length: 833  Bit Score: 50.41  E-value: 2.68e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2127 AADAEMEKhkkfAEQTLRQKAQVEQELTTLRLQLEET-DHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEEL 2205
Cdd:COG5281   301 AAAAAAEA----AAAMDDRTARVKENMGTLETAWDALaDAAKKMWDAVLGIGREDKQAALLAAKLAAEKLARVTAQGALN 376
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2206 GKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2285
Cdd:COG5281   377 ARLKLAQDDLTQAELNYAAADQAANQEGALNAREDEAEVLSTQEERRDILKNLLADAEKRTARQEELNKALAKAKILQAD 456
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2286 EATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEEtqgFQRTLEAERQRQLemSAEAERLKLRMAEMSRAQarAE 2365
Cdd:COG5281   457 KAAKAYQEDILQREAQSRGKTAAAERSQEQMTAALKALLA---FQQQIADLSGAKE--KASDQKSLLWKAEEQYAL--LK 529
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251 2366 EDAQRFRKQAEEIGEKLHRTELATQEkvtlvQTLEIQRQQSDHDAERLREAIAELEREKEKLKQ 2429
Cdd:COG5281   530 EEAKQRQLQEQKALLEHKKETLEYTS-----QLAELLDQQADRFELSAQAAGSQKERGSDLYRE 588
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2131-2580 2.78e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.45  E-value: 2.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2131 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDE---ELQRLKAEVTEAARQRSQVEE---ELFSVRVQMEE 2204
Cdd:PRK03918  294 EYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEkeeRLEELKKKLKELEKRLEELEErheLYEEAKAKKEE 373
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2205 LGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSvaaQEAARL------------------RQLAEED- 2265
Cdd:PRK03918  374 LERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELK---KEIKELkkaieelkkakgkcpvcgRELTEEHr 450
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2266 ---LAQQRALAEKMLKEKMQAVQEATRLKAEAE----LLQQQKELA--QEQARRLQEDKEQMAQQLVEETQGFQRTLEAE 2336
Cdd:PRK03918  451 kelLEEYTAELKRIEKELKEIEEKERKLRKELRelekVLKKESELIklKELAEQLKELEEKLKKYNLEELEKKAEEYEKL 530
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2337 RQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQtLEIQRQQSDHDAE-RLRE 2415
Cdd:PRK03918  531 KEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELGFESVEELE-ERLKELEPFYNEYlELKD 609
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2416 AIAELEREKEKLKQEAKLLQLKSEEMQTVQQ--EQILQETQALQKSFlSEKDSLLQRERFIEQEKakleqlfqdEVAKAK 2493
Cdd:PRK03918  610 AEKELEREEKELKKLEEELDKAFEELAETEKrlEELRKELEELEKKY-SEEEYEELREEYLELSR---------ELAGLR 679
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2494 qlreeqqrqqqqmeqekqelmASMEEARRRQREAEEGVR--RKQEELQHLEQQRQQQEKLLAEENQRLRERLQRL--EEE 2569
Cdd:PRK03918  680 ---------------------AELEELEKRREEIKKTLEklKEELEEREKAKKELEKLEKALERVEELREKVKKYkaLLK 738
                         490
                  ....*....|.
gi 254675251 2570 HRAALAHSEIA 2580
Cdd:PRK03918  739 ERALSKVGEIA 749
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
1323-1544 3.02e-05

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 430825 [Multi-domain]  Cd Length: 305  Bit Score: 49.35  E-value: 3.02e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1323 ERERLAEVEAALEKQRQLAEAHAQAKAQAE---LEAQELQRRMQEEVarreeaavdaqqqkRSIQEELQHLRQSSEAEIQ 1399
Cdd:pfam09787   42 STALSLELDELRQERDLLREELQQLNQQIEqlrTELQELEAQQQEEA--------------ESSREQLQDLEEQLATERQ 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1400 AKaqqvEAAERSRMRIEEEIRVVRLQLETTERQrggaegelqaLRARAEEAEAqkrqaqeEAERLRRQVQDESQRKRQaE 1479
Cdd:pfam09787  108 AR----REAEAELERLQEELRYLEEELRRTKAT----------LQSRIKDREA-------EIEKLRNQLTNKSQSSSS-Q 165
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251  1480 AELALRVKAEAEAAREKQRALQAL----DELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQ 1544
Cdd:pfam09787  166 SELENRLHQLTESLIQKQTMLEALstekNSLVLQLERLEQQIKELQGEASNGTSINMEGISDEEGTRLR 234
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
1494-1795 3.26e-05

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 49.53  E-value: 3.26e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1494 REKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASfAEKTAQLERTLQEEHVTVAQLRE 1573
Cdd:pfam13868   31 KKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKQYRQELEEQIEERE-QKRQEEYEEKLQEREQMDEIVER 109
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1574 EAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRE 1653
Cdd:pfam13868  110 IQEEDQAEAEEKLEKQRQLREEIDEFNEEQAKWKELEKEEEKEEDLRILEYLKEKAEREEEREAERREIKEEKEREIARL 189
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1654 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAatQKRQELEAELAKVRAEMEVLL 1733
Cdd:pfam13868  190 RAQQEKAQDEKAERDELRAKLYQEEQERKWRQKEREEAEKKARQRQELQQAREEQIE--LKERRLAEEAEREEEEFERML 267
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675251  1734 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1795
Cdd:pfam13868  268 RKQAEDEEIEQEEAEKRREKRLEHRRELEKQIEERERQRAAEREEELEEGERLREEEAERRE 329
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1154-1448 3.34e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227278 [Multi-domain]  Cd Length: 420  Bit Score: 49.72  E-value: 3.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1154 QAVLAQTDVRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAVPIA---NCQAAREQLRQEKALLEEIErhGEKV 1230
Cdd:COG4942    34 AADDKQLKQIQKEIAALEKKIREQQDQRAKLEKQLKSLETEIASLEAQLIEtadDLKKLRKQIADLNARLNALE--VQER 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1231 EECQKFAKQyINAIkdyelqlitYKAQLEPvaSPAKKpkvQSGSESviQEYVDLRTRYSELTTLTSQYIKFISETLRRME 1310
Cdd:COG4942   112 EQRRRLAEQ-LAAL---------QRSGRNP--PPALL---VSPEDA--QRSVRLAIYYGALNPARAERIDALKATLKQLA 174
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1311 EEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEevarreeaavdAQQQKRSIQEELQHL 1390
Cdd:COG4942   175 AVRAEIAAEQAELTTLLSEQRAQQAKLAQLLEERKKTLAQLNSELSADQKKLEE-----------LRANESRLKNEIASA 243
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251 1391 RQsSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAE 1448
Cdd:COG4942   244 EA-AAAKAREAAAAAEAAAARARAAEAKRTGETYKPTAPEKMLISSTGGFGALRGQLA 300
RecN COG0497
DNA repair ATPase RecN [Replication, recombination and repair];
1660-1938 3.51e-05

DNA repair ATPase RecN [Replication, recombination and repair];


Pssm-ID: 223571 [Multi-domain]  Cd Length: 557  Bit Score: 49.91  E-value: 3.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1660 EKQRQLAEGTAQQRLAAEQELirlraetEQGEQQRQLLEEELARLQheataatQKRQELEAELAKVRAEMEVLLASKARA 1739
Cdd:COG0497   139 ELQRQLLDAFAGLEELAQEAY-------QEAYQAWKQARRELEDLQ-------EKERERAQRADLLQFQLEELEELNLQP 204
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1740 EEESRSTSEKSKQrleAEAGRFRELAEEAarLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRlktEAEI 1819
Cdd:COG0497   205 GEDEELEEERKRL---SNSEKLAEAIQNA--LELLSGEDDTVSALSLLGRALEALEDLSEYDGKLSELAELLE---EALY 276
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1820 ALKEKEAEnerLRRLAEDEAFQRRRLEEqaalhkadIEERLAQLRKASeselERQKGLVEDTLRQRRQVEEEIMALKVSF 1899
Cdd:COG0497   277 ELEEASEE---LRAYLDELEFDPNRLEE--------VEERLFALKSLA----RKYGVTIEDLLEYLDKIKEELAQLDNSE 341
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 254675251 1900 EKaaagKAELELELGRIRSNAEdtmrsKEQAELEAARQR 1938
Cdd:COG0497   342 ES----LEALEKEVKKLKAELL-----EAAEALSAIRKK 371
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
2655-2693 3.57e-05

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 43.48  E-value: 3.57e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  2655 YLKGRSSIAGLLLKPTNEKLSVYTALQRQLLSPGTALIL 2693
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
1681-1986 3.73e-05

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 49.95  E-value: 3.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1681 IRLRA-ETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAK-----VRAEMEVLLASKARAEEE-SRSTSEKSKQR 1753
Cdd:PRK05035  438 IRAIEqEKKKAEEAKARFEARQARLEREKAAREARHKKAAEARAAkdkdaVAAALARVKAKKAAATQPiVIKAGARPDNS 517
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1754 LEAEAGRFRELAEEAARLRALAEEAKRQRQlAEEDAARQRAEAERvlteklaaiseatrlkteAEIALKEKEAENERLRR 1833
Cdd:PRK05035  518 AVIAAREARKAQARARQAEKQAAAAADPKK-AAVAAAIARAKAKK------------------AAQQAANAEAEEEVDPK 578
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1834 LAEDEAFQRRrleeqaalhkadieerlAQLRKASESELERQKGLVEDTLRQRRQVEEEIMAlkvsfeKAAAGKAELELEL 1913
Cdd:PRK05035  579 KAAVAAAIAR-----------------AKAKKAAQQAASAEPEEQVAEVDPKKAAVAAAIA------RAKAKKAEQQANA 635
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251 1914 grIRSNAEDTMRSKEQAELEAARQRQLaaeeeqrrreaeeRVQRSLAAEEEAARQRKVALE-EVERLKAKVEEA 1986
Cdd:PRK05035  636 --EPEEPVDPRKAAVAAAIARAKARKA-------------AQQQANAEPEEAEDPKKAAVAaAIARAKAKKAAQ 694
PLEC smart00250
Plectin repeat;
4349-4386 3.81e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.24  E-value: 3.81e-05
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 254675251   4349 QRFLEVQYLTGGLIEPDTPGRVSLDEALQRGTVDARTA 4386
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
ERM pfam00769
Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at ...
2183-2349 3.83e-05

Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at their amino terminus. This family represents the rest of these proteins.


Pssm-ID: 425860 [Multi-domain]  Cd Length: 247  Bit Score: 48.40  E-value: 3.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2183 EAARQRSQVEEELfsvrVQMEElgklkariEAENRALILRDKDNTQRFLEEeaeKMKQVAEEAARLSVAAQEAarlrqla 2262
Cdd:pfam00769    3 EAEREKQELEERL----KQYEE--------ETRKAQEELEESEETAELLEE---KLRVAEEEAELLEQKAQEA------- 60
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2263 EEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLE 2342
Cdd:pfam00769   61 EEEKERLEESAEMEAEEKEQLERELREAQEEVARLEEESERKEEEAERLQEELEEAREEEEEAKEKLLAASTSPSHHHSE 140

                   ....*..
gi 254675251  2343 MSAEAER 2349
Cdd:pfam00769  141 ESENEDD 147
PLEC smart00250
Plectin repeat;
3314-3349 3.93e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.24  E-value: 3.93e-05
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 254675251   3314 LLQGSGCLAGIYLEDSKEKVTIYEAMRRGLLRPSTA 3349
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
2102-2325 3.94e-05

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 225177 [Multi-domain]  Cd Length: 548  Bit Score: 49.83  E-value: 3.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2102 KLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQtlRQKAQVEQELTTLRLQLEETDHQKSIldEELQRLKAEV 2181
Cdd:COG2268   246 KLVELEVEQQPAGKTAEQTREVKIILAETEAEVAAWKAET--RREAEQAEILAEQAIQEEKAQAEQEV--QHAKALEARE 321
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2182 TEAARQRSQVEEELF-SVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQ 2260
Cdd:COG2268   322 MRVGLIERQKETELEpQERSYFINAAQRQAQEEAKAAANIAEAIGAQAEAAVETARETEEAERAEQAALVAAAEAAEQEQ 401
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675251 2261 LAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK------ELAQEQARRLQEDKEQMAQQLVEE 2325
Cdd:COG2268   402 VEIAVRAEAAKAEAEAQAAEIKAEAEAIREKGKAEAEAKRAlaeaiqVLGDAAAAELFKALVQALPEVAEE 472
DUF812 pfam05667
Protein of unknown function (DUF812); This family consists of several eukaryotic proteins of ...
2173-2459 4.06e-05

Protein of unknown function (DUF812); This family consists of several eukaryotic proteins of unknown function.


Pssm-ID: 428574 [Multi-domain]  Cd Length: 601  Bit Score: 49.62  E-value: 4.06e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2173 ELQRLKAEVTEAARQRSQVEEELFSVRVQmeelgKLKARIEAENRALILRDKDNTQRFLEEEAE--KMKQVAEEAARLSV 2250
Cdd:pfam05667  218 AAQEWEEEWNSQGLASRLTPEEYRKRKRT-----KLLKRIAEQLRSAALASTEATSGASRSKQDlaELLSSFGGSSTTDT 292
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2251 AAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAEL--LQQQKELAQEQARRLQEDKEQMA---QQLVEE 2325
Cdd:pfam05667  293 NLTKGSRFTHTEKLQFTNEEAPAATSSPPTKAETEEELQQQREEELeeLQEQLEELESSIEELEKEIKKLEssiKQVEEE 372
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2326 TQgfqrtleaERQRQLEMSAEAERLKLRMAE--------MSRAQARAEEDAQRFRKQAEEIGEklHRT------------ 2385
Cdd:pfam05667  373 LE--------ELKEQNEELEKQYKVKKKTLDllpdaeenIAKLQALVEASAQRLVELAGQWEK--HRVplieeyralkea 442
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2386 ----ELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEA-------KLLQL-KSEEMQTVQQEQILQET 2453
Cdd:pfam05667  443 ksnkESESQRKLEEIKELREKIKEVAEEARSKEELYKQLVAEYERLPKDVnrsaytrRILEIvKNIKKQKEEITKILSDT 522

                   ....*.
gi 254675251  2454 QALQKS 2459
Cdd:pfam05667  523 KSLQKE 528
Caldesmon pfam02029
Caldesmon;
1626-2015 4.11e-05

Caldesmon;


Pssm-ID: 426572 [Multi-domain]  Cd Length: 490  Bit Score: 49.48  E-value: 4.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1626 DAEKQKEEAEREARRRGKAEEQAVRQrELAEQELEKQRQlaegtaqqrlaAEQELIRLRAETEQGEQQRQLLEEELARLQ 1705
Cdd:pfam02029    5 EAARERRRRAREERRRQKESEEPSSQ-EDSQPEVNAQEE-----------AEEEDSELKPSGQGGLDEEEAFLDRTAKRE 72
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1706 HEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKsKQRLEAEAGRfRELAEEAARLRALAEEAKRQRQLA 1785
Cdd:pfam02029   73 ERRQKRLQEALERQKELDPTITDEQASKPRSTENTPEEKNNTEE-EEKSSTRKER-YEIEEREVSEKSYEKDDKKAVPKE 150
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1786 EEDAARQRAEAERVlteklaaiseatrlktEAEIALKEKEAENERLRRLAEDEAF--QRRRLEEQaalhkadieerlaql 1863
Cdd:pfam02029  151 EEEEEDAKTEEEEE----------------EEEEEKKVSKKKKEKLKDEYTSKVFldQKKGHPEQ--------------- 199
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1864 rKASESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELELGRiRSNAEdtmrsKEQAELEAARQRQLAAE 1943
Cdd:pfam02029  200 -KSQNGALEEVTSMTVKLKRTERTFSQKSLVAEDEEEGAAFLEAEQKLEELR-RRRQE-----KESQEFEKLRQKQQEAE 272
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675251  1944 EEQRRREAEERVQRSLAAEEEaaRQRKValEEVERLKAKVEEARRLRERAEQESArqlqlaqEAAQKRLQAE 2015
Cdd:pfam02029  273 LELEELKKKREERRKILEEEE--QRRKQ--EEAERKAREEEEKRRMKEEIERRRA-------EAAEKRQKME 333
CH_PARVA_B_rpt2 cd21306
second calponin homology (CH) domain found in the alpha/beta parvin subfamily; The alpha/beta ...
5-112 4.18e-05

second calponin homology (CH) domain found in the alpha/beta parvin subfamily; The alpha/beta parvin subfamily includes alpha-parvin and beta-parvin. Alpha-parvin, also called actopaxin, calponin-like integrin-linked kinase-binding protein (CH-ILKBP), or matrix-remodeling-associated protein 2, plays a role in sarcomere organization and in smooth muscle cell contraction. It is required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Beta-parvin, also called affixin, is an adapter protein that plays a role in integrin signaling via ILK and in activation of the GTPases Cdc42 and Rac1 by guanine exchange factors, such as ARHGEF6. Both alpha-parvin and beta-parvin are involved in the reorganization of the actin cytoskeleton and the formation of lamellipodia, and both play roles in cell adhesion, cell spreading, establishment or maintenance of cell polarity, and cell migration. Members of this subfamily contain two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409155  Cd Length: 121  Bit Score: 45.87  E-value: 4.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    5 PDERDRVqKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMRF----HKLQNVQIALDYLRH 80
Cdd:cd21306    11 PDKLNVV-KKSLITFVNKHLNKLNLEVTDLDTQFHDGVYLVLLMGLLEGYFVPLHSFHLTPtsfeQKVHNVQFAFELMQD 89
                          90       100       110
                  ....*....|....*....|....*....|..
gi 254675251   81 RQVKLVNIRNDDIADGNPKLTLGLIWTIILHF 112
Cdd:cd21306    90 AGLPKPKARPEDIVNLDLKSTLRVLYNLFTKY 121
PLEC smart00250
Plectin repeat;
4100-4128 4.33e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 43.24  E-value: 4.33e-05
                            10        20
                    ....*....|....*....|....*....
gi 254675251   4100 VRKRRVVIVDPETGKEMSVYEAYRKGLID 4128
Cdd:smart00250    6 AQSAIGGIIDPETGQKLSVEEALRRGLID 34
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
2131-2541 5.06e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 49.68  E-value: 5.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2131 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKA------EVTEAARQRSQVEEELFSVRVQMEE 2204
Cdd:PRK03918  232 ELEELKEEIEELEKELESLEGSKRKLEEKIRELEERIEELKKEIEELEEkvkelkELKEKAEEYIKLSEFYEEYLDELRE 311
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2205 LGKLKARIEAENRALI--LRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEdlaqqralAEKMLKEKmq 2282
Cdd:PRK03918  312 IEKRLSRLEEEINGIEerIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEE--------LERLKKRL-- 381
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2283 AVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQ-----RQLEMSAEAERLKLRMAEM 2357
Cdd:PRK03918  382 TGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKcpvcgRELTEEHRKELLEEYTAEL 461
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2358 SRAQ---ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKL-KQEAKL 2433
Cdd:PRK03918  462 KRIEkelKEIEEKERKLRKELRELEKVLKKESELIKLKELAEQLKELEEKLKKYNLEELEKKAEEYEKLKEKLiKLKGEI 541
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2434 LQLKSE----------------EMQTVQQE--------------------QILQETQALQKSFLSEKDS---LLQRERFI 2474
Cdd:PRK03918  542 KSLKKElekleelkkklaelekKLDELEEElaellkeleelgfesveeleERLKELEPFYNEYLELKDAekeLEREEKEL 621
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251 2475 EQEKAKLEQLFqDEVAKAKQLREEQQRQQQQMEQEKQELmaSMEEARRRQREAEEGVRRKQEELQHL 2541
Cdd:PRK03918  622 KKLEEELDKAF-EELAETEKRLEELRKELEELEKKYSEE--EYEELREEYLELSRELAGLRAELEEL 685
ERM pfam00769
Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at ...
1348-1482 5.66e-05

Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at their amino terminus. This family represents the rest of these proteins.


Pssm-ID: 425860 [Multi-domain]  Cd Length: 247  Bit Score: 48.01  E-value: 5.66e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1348 KAQAELEAQELQRR---MQEEVARREEAAVDAQQQKRSIQEELQHLRQSSeaeiqakaqqvEAAERSRMRIEEEIRVVRL 1424
Cdd:pfam00769    1 REEAEREKQELEERlkqYEEETRKAQEELEESEETAELLEEKLRVAEEEA-----------ELLEQKAQEAEEEKERLEE 69
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251  1425 QLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAEL 1482
Cdd:pfam00769   70 SAEMEAEEKEQLERELREAQEEVARLEEESERKEEEAERLQEELEEAREEEEEAKEKL 127
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
1427-1678 5.75e-05

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 48.69  E-value: 5.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1427 ETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDEL 1506
Cdd:TIGR02794   25 HSVKPEPGGGAEIIQAVLVDPGAVAQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAA 104
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1507 RlQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEhvtvaqlreEAERRAQQQAEAE 1586
Cdd:TIGR02794  105 K-QAEQAAKQAEEKQKQAEEAKAKQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAA---------AEAKKKAEEAKKK 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1587 RAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKeeaEREARRRGKAEEQAVRQRELAEQELEKQRQla 1666
Cdd:TIGR02794  175 AEAEAKAKAEAEAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAA---AAAAEAERKADEAELGDIFGLASGSNAEKQ-- 249
                          250
                   ....*....|..
gi 254675251  1667 EGTAQQRLAAEQ 1678
Cdd:TIGR02794  250 GGARGAAAGSEV 261
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1899-2458 5.94e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 49.29  E-value: 5.94e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1899 FEKAAAGKAELELELGRIRSNAEDTMRSKEQAElEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKvalEEVER 1978
Cdd:PRK03918  160 YENAYKNLGEVIKEIKRRIERLEKFIKRTENIE-ELIKEKEKELEEVLREINEISSELPELREELEKLEKEV---KELEE 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1979 LKAKVEEARRLRERAEQEsARQLQLAQEAAQKRLqAEEKAHAFVVQQREEELQQTLQQEQNMLdRLRSEAEAARRAAEEA 2058
Cdd:PRK03918  236 LKEEIEELEKELESLEGS-KRKLEEKIRELEERI-EELKKEIEELEEKVKELKELKEKAEEYI-KLSEFYEEYLDELREI 312
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2059 EEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRKEAEQEAARRAQAEQAALKQKQAADAEMEKHKKF 2138
Cdd:PRK03918  313 EKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKE 392
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2139 AEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLK----------AEVTEAARQR--SQVEEELFSVRVQMEELG 2206
Cdd:PRK03918  393 LEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKkakgkcpvcgRELTEEHRKEllEEYTAELKRIEKELKEIE 472
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2207 KLKARIEAENRAL-ILRDKDNTQRFLEEEAEKMKQVAEE-----AARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2280
Cdd:PRK03918  473 EKERKLRKELRELeKVLKKESELIKLKELAEQLKELEEKlkkynLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLE 552
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2281 MQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQlEMSAEAERLKLRMAEMSRA 2360
Cdd:PRK03918  553 ELKKKLAELEKKLDELEEELAELLKELEELGFESVEELEERLKELEPFYNEYLELKDAEK-ELEREEKELKKLEEELDKA 631
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2361 Q---ARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTL------------VQTLEIQRQQSDHDAERLREAIAELEREKE 2425
Cdd:PRK03918  632 FeelAETEKRLEELRKELEELEKKYSEEEYEELREEYLelsrelaglraeLEELEKRREEIKKTLEKLKEELEEREKAKK 711
                         570       580       590
                  ....*....|....*....|....*....|...
gi 254675251 2426 KLKQEAKLLQLKSEEMQTVQQEQILQETQALQK 2458
Cdd:PRK03918  712 ELEKLEKALERVEELREKVKKYKALLKERALSK 744
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organisation of microtubules varies with the cell type and is ...
1408-1527 5.95e-05

MAP7 (E-MAP-115) family; The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilizing protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 428577 [Multi-domain]  Cd Length: 153  Bit Score: 46.17  E-value: 5.95e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1408 AERSRMRIEEEIRVVRLQLETTERQRggaegELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELAlrvK 1487
Cdd:pfam05672    9 AEEAARILAEKRRQAREQREREEQER-----LEKEEEERLRREELRRRAEEERARREEEARRLEEERKREEEERQR---K 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 254675251  1488 AEAEAAREKQRALQALDELRLQAEEAERRLRQaEAERARQ 1527
Cdd:pfam05672   81 AEEEAEEKEQREKEEQERLQKQKEEAEAKARE-EAERQRQ 119
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 ...
2135-2457 6.14e-05

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 substr. MG1655 [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 225638 [Multi-domain]  Cd Length: 1480  Bit Score: 49.50  E-value: 6.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2135 HKKFAEQTLRQKAQVEQ---ELTTLRLQLEEtdhQKSILDEELQRLKaevtEAARQRSQVEEELFSVRVQM----EELGK 2207
Cdd:COG3096   336 HLNLVQTALRQQEKIERyqaDLEELTIRLEE---QNEVVEEANERQE----ENEARAEAAELEVDELKSQLadyqQALDV 408
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2208 LKAR-------IEAENRALILRDK-DNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKE 2279
Cdd:COG3096   409 QQTRaiqyqqaIAALERAKELCHLpDLTADSAEEWLETFQAKEEEATEKLLSLEQKMSMAQAAHSQFEQAYQLVVAIAGE 488
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2280 --KMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQlveetQGFQRTLEAERQRQ------LEMSAEAERLK 2351
Cdd:COG3096   489 laRSEAWDVARELLREGPDQRHLAEQVQPLRMRLSELEQRLRQQ-----QSAERLLADFCKRQgknldaEELEALHQELE 563
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2352 LRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELERekeklkqea 2431
Cdd:COG3096   564 ALIESLSDSVSNAREQRMALRQEQEQLQSRIQSLMQRAPVWLAAQNALEQLSEQSGEEFTDSQDVTEYMQQ--------- 634
                         330       340
                  ....*....|....*....|....*.
gi 254675251 2432 kllQLKSEEMQTVQQEQILQETQALQ 2457
Cdd:COG3096   635 ---LLEREREATVERDELGARKNALD 657
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
1642-2020 6.40e-05

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 411407 [Multi-domain]  Cd Length: 684  Bit Score: 49.24  E-value: 6.40e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1642 GKAEEQAVRQRELAEQELEK-----QRQLAEGTAQQRLAAEQELIRLRAE--TEQGEQQRQLLEEELARLQHEATAATQK 1714
Cdd:NF033838   50 SSGNESQKEHAKEVESHLEKilseiQKSLDKRKHTQNVALNKKLSDIKTEylYELNVLKEKSEAELTSKTKKELDAAFEQ 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1715 RQELEAELAKVRAEMEVLLA-----SKARAEEESRSTSEKSKQRLEAEAGRFrELAEEAARLRALAEEAKRQRQLAEEDA 1789
Cdd:NF033838  130 FKKDTLEPGKKVAEATKKVEeaekkAKDQKEEDRRNYPTNTYKTLELEIAES-DVEVKKAELELVKEEAKEPRDEEKIKQ 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1790 ARQRAEAERvlteklaaiSEATRLKteaEIALKEKEAENERLRR------------LAEDEAFQRRRLEEQAALHKADIE 1857
Cdd:NF033838  209 AKAKVESKK---------AEATRLE---KIKTDREKAEEEAKRRadaklkeaveknVATSEQDKPKRRAKRGVLGEPATP 276
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1858 ERLAQLRKASESELERQKgLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAE------------LELELgrirsnAEDTMR 1925
Cdd:NF033838  277 DKKENDAKSSDSSVGEET-LPSPSLKPEKKVAEAEKKVEEAKKKAKDQKEEdrrnyptntyktLELEI------AESDVK 349
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1926 SKEqAELEAARQRqlaaeeeqrrreaeervqrslAAEEEAARQRKVALEEVERLKA---KVEEARRLRERAEQESARQLQ 2002
Cdd:NF033838  350 VKE-AELELVKEE---------------------AKEPRNEEKIKQAKAKVESKKAeatRLEKIKTDRKKAEEEAKRKAA 407
                         410
                  ....*....|....*...
gi 254675251 2003 LAQEAAQKRLQAEEKAHA 2020
Cdd:NF033838  408 EEDKVKEKPAEQPQPAPA 425
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1399-1555 6.44e-05

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 48.79  E-value: 6.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1399 QAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKrqAQEEAERLRRQVQDESQrkrQA 1478
Cdd:COG3064    63 QYGRIQSQQSSAKKGEQQRKKKEEQVAEELKPKQAAEQERLKQLEKERLKAQEQQK--QAEEAEKQAQLEQKQQE---EQ 137
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251 1479 EAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTA 1555
Cdd:COG3064   138 ARKAAAEQKKKAEAAKAKAAAEAAKLKAAAEAKKKAEEAAKAAEEAKAKAEAAAAKKKAEAEAKAAAEKAKAEAEAK 214
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1590-1996 6.74e-05

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 428520 [Multi-domain]  Cd Length: 660  Bit Score: 48.96  E-value: 6.74e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1590 EEAERELERWQLKANEAL-RLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEg 1668
Cdd:pfam05557   37 SALARQLERESDRNQELQkRIRLLEKREAEAEEALREQAELNRLKKKNLEALNKKLNEKESQLADAREVISCLKNELSE- 115
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1669 TAQQRLAAEQELIRLRAETEQGEQQRQLLE----------EELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKar 1738
Cdd:pfam05557  116 LRRQIQRQELELSSTNSELEELQERLDLQKakaqeaeqlrQNLEAQQSSLAEAEQRIKELEFEIQSQEQDSEIVKNSK-- 193
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1739 AEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKR---QRQLAEEDAARQRAEAERVLTE----KLAAISEAT 1811
Cdd:pfam05557  194 SELARIPELERELERLREHNKHLNENIENKLLLKEEVEDLKRkleREEGYREELATLELEKEKLEQElkswEKLAQDTGL 273
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1812 RLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALhkADIEERLAQLRKASESE---LERQKGLVEDTLRQRRQV 1888
Cdd:pfam05557  274 NLRSPEDLSRRIEQLQQREITLKEENSSLTSSARQLEKAQ--RELEQELAQYLKNIEDLnkkLKRHKALVRRLQRRVLLL 351
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1889 EEEIMALKV---SFEKAAAGKAELELELGRIRSNAEdtMRSKEQAELEAARQRqlaAEEEQRRREAEERVQRSLAAEEEA 1965
Cdd:pfam05557  352 TKERDGMRAileSYDKELTPSNYSPQLLERIEEAED--MTQDMQAHNEEMEAQ---LSVAEEELGGYKQQATTLERELQA 426
                          410       420       430
                   ....*....|....*....|....*....|....*..
gi 254675251  1966 ARQ------RKVALEEVERLKAKVEEARRLRERAEQE 1996
Cdd:pfam05557  427 LRQqesladPSYSKEEVDSLRRKLETLEAERQRLREQ 463
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
1331-1831 6.78e-05

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 49.28  E-value: 6.78e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1331 EAALEKQRQLAEAhAQAKAQAELeAQELQRRMQEeVARREEAAVDAQQQKRSIQE---ELQHLRQSSEAEiqakaqqvea 1407
Cdd:PRK10929   25 EKQITQELEQAKA-AKTPAQAEI-VEALQSALNW-LEERKGSLERAKQYQQVIDNfpkLSAELRQQLNNE---------- 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1408 aersrmriEEEIRVVRLQLETterqrggAEGELQALRARAEEAEaQKRQAQEEAERLRRQVQDESQ-RKRQAEAELALrv 1486
Cdd:PRK10929   92 --------RDEPRSVPPNMST-------DALEQEILQVSSQLLE-KSRQAQQEQDRAREISDSLSQlPQQQTEARRQL-- 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1487 kAEAEaarekqRALQALDELRLQAEEAERRLRQAEAerarqvqvaletAQRSAEVElqskrasfaektaqlertlqeehv 1566
Cdd:PRK10929  154 -NEIE------RRLQTLGTPNTPLAQAQLTALQAES------------AALKALVD------------------------ 190
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1567 tvaqlreeaerraqqqaeaerareeaerELERWQLKAN---EALRLRLqaeEVAQQKSlAQADAEKQKEeaerearrrgK 1643
Cdd:PRK10929  191 ----------------------------ELELAQLSANnrqELARLRS---ELAKKRS-QQLDAYLQAL----------R 228
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1644 AEEQAVRQRElAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLeEELARLQHEATAATQK-RQELEA-- 1720
Cdd:PRK10929  229 NQLNSQRQRE-AERALESTELLAEQSGDLPKSIVAQFKINRELSQALNQQAQRM-DLIASQQRQAASQTLQvRQALNTlr 306
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1721 ----ELAKVRAEMEVLLASKARAEEESRStsekskQRLEAEAGRFRelaeeAARLR--ALAEEAKRQRQLAEEDAARQRA 1794
Cdd:PRK10929  307 eqsqWLGVSNALGEALRAQVARLPEMPKP------QQLDTEMAQLR-----VQRLRyeDLLNKQPQLRQIRQADGQPLTA 375
                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 1795 EAERVLTEKLAA---------------ISEATRLK---TEAEIALKE-KEAENERL 1831
Cdd:PRK10929  376 EQNRILDAQLRTqrellnsllsggdtlILELTKLKvanSQLEDALKEvNEATHRYL 431
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
1746-2025 7.23e-05

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 48.37  E-value: 7.23e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1746 TSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEA-EIALKEK 1824
Cdd:pfam13868   21 NKERDAQIEEKKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKQYRQELEEQIEEREQKRQEEyEEKLQER 100
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1825 EAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALKvsfEKAAA 1904
Cdd:pfam13868  101 EQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAKWKELEKEEEKEEDLRILEYLKEKAEREEERE---AERRE 177
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1905 GKAELELELGRIRSNAEDTMRSKEQAElEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEEVERLKAK-V 1983
Cdd:pfam13868  178 IKEEKEREIARLRAQQEKAQDEKAERD-ELRAKLYQEEQERKWRQKEREEAEKKARQRQELQQAREEQIELKERRLAEeA 256
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|..
gi 254675251  1984 EEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFVVQQ 2025
Cdd:pfam13868  257 EREEEEFERMLRKQAEDEEIEQEEAEKRREKRLEHRRELEKQ 298
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
1429-2031 7.41e-05

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 49.03  E-value: 7.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1429 TERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQ--VQDESQRKRQA--EAELALRVKAEAEAARE--------- 1495
Cdd:PRK10246  214 TPEQVQSLTASLQVLTDEEKQLLTAQQQQQQSLNWLTRLdeLQQEASRRQQAlqQALAAEEKAQPQLAALSlaqparqlr 293
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1496 -----KQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQrsaevELQSKRASFAEKTAQLERTL---QEEHVT 1567
Cdd:PRK10246  294 phwerIQEQSAALAHTRQQIEEVNTRLQSTMALRARIRHHAAKQSA-----ELQAQQQSLNTWLAEHDRFRqwnNELAGW 368
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1568 VAQLREEAERRAQQQAEAERAREEaereleRWQLKANEALRLRLQAEEVAQqkslAQADAEKQKEEAEREARRRGKAEEQ 1647
Cdd:PRK10246  369 RAQFSQQTSDREQLRQWQQQLTHA------EQKLNALPAITLTLTADEVAA----ALAQHAEQRPLRQRLVALHGQIVPQ 438
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1648 AVRQRELAE------QELEKQRQLAEGTAQQRLAAEQELIRLRAETEQgEQQRQLLEEELARLQ------------HEAT 1709
Cdd:PRK10246  439 QKRLAQLQVaiqnvtQEQTQRNAALNEMRQRYKEKTQQLADVKTICEQ-EARIKDLEAQRAQLQagqpcplcgstsHPAV 517
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1710 AATQ---------KRQELEAELAK-------VRAEMEVLLASKARAEEESRSTSEKSK------QRLEAEAGRFRELAEE 1767
Cdd:PRK10246  518 EAYQalepgvnqsRLDALEKEVKKlgeegaaLRGQLDALTKQLQRDESEAQSLRQEEQaltqqwQAVCASLNITLQPQDD 597
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1768 AARLRALAEEAKRQ-RQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIA-----LKEKEAENERLRRLAEDEAFQ 1841
Cdd:PRK10246  598 IQPWLDAQEEHERQlRLLSQRHELQGQIAAHNQQIIQYQQQIEQRQQQLLTALAgyaltLPQEDEEASWLATRQQEAQSW 677
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1842 RRRLEEQAALhkadiEERLAQLRKASESELERQKGLVED---TLRQRRQVEEEIMALKvsfEKAAAGKAELELELGRIrs 1918
Cdd:PRK10246  678 QQRQNELTAL-----QNRIQQLTPLLETLPQSDDLPHSEetvALDNWRQVHEQCLSLH---SQLQTLQQQDVLEAQRL-- 747
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1919 naedtmrSKEQAELEAARQrqlaaeeeqrrREAEERVQRSLAA-EEEAARQRKVALEEveRLKAKVEEARRLRERAEQES 1997
Cdd:PRK10246  748 -------QKAQAQFDTALQ-----------ASVFDDQQAFLAAlLDEETLTQLEQLKQ--NLENQRQQAQTLVTQTAQAL 807
                         650       660       670       680
                  ....*....|....*....|....*....|....*....|..
gi 254675251 1998 ARQLQLAQEAAQKRLQAE--EKAHAFVVQQ------REEELQ 2031
Cdd:PRK10246  808 AQHQQHRPDGLDLTVTVEqiQQELAQLAQQlrenttRQGEIR 849
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
2122-2340 7.70e-05

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 380155 [Multi-domain]  Cd Length: 1848  Bit Score: 49.45  E-value: 7.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2122 LKQKQAA-DAEMEKHKKFAE-QTLRQ-KAQVEQELTTLRLQLEETDHQksildeelqrlkAEVTEAARQRSQVEEELFSV 2198
Cdd:NF012221 1551 AKQDDAAqNALADKERAEADrQRLEQeKQQQLAAISGSQSQLESTDQN------------ALETNGQAQRDAILEESRAV 1618
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2199 RVQMEELGKlkaRIEA----------------ENRALILRDK-----DNTQRFLEEEAEKMKQ--------VAEEAARLS 2249
Cdd:NF012221 1619 TKELTTLAQ---GLDAldsqatyagesgdqwrNPFAGGLLDRvqeqlDDAKKISGKQLADAKQrhvdnqqkVKDAVAKSE 1695
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2250 VAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQlveETQGF 2329
Cdd:NF012221 1696 AGVAQGEQNQANAEQDIDDAKADAEKRKDDALAKQNEAQQAESDANAAANDAQSRGEQDASAAENKANQAQA---DAKGA 1772
                         250
                  ....*....|.
gi 254675251 2330 QRTLEAERQRQ 2340
Cdd:NF012221 1773 KQDESDKPNRQ 1783
PLEC smart00250
Plectin repeat;
3761-3797 7.88e-05

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 42.47  E-value: 7.88e-05
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3761 LRLLDAQLATGGIVDPRLGFHLPLEVAYQRGYLNKDT 3797
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
Caldesmon pfam02029
Caldesmon;
1308-1518 8.15e-05

Caldesmon;


Pssm-ID: 426572 [Multi-domain]  Cd Length: 490  Bit Score: 48.71  E-value: 8.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1308 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEE-----VARREEAAVDAQQQKRS 1382
Cdd:pfam02029  126 RYEIEEREVSEKSYEKDDKKAVPKEEEEEEDAKTEEEEEEEEEEKKVSKKKKEKLKDEytskvFLDQKKGHPEQKSQNGA 205
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1383 IQEELQHLRQ--SSEAEIQAKAQQVEAAERSRMRIEEEIRvvrlqLETTERQRGGAE-GELQALRARAEEAEAQKRQAQE 1459
Cdd:pfam02029  206 LEEVTSMTVKlkRTERTFSQKSLVAEDEEEGAAFLEAEQK-----LEELRRRRQEKEsQEFEKLRQKQQEAELELEELKK 280
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251  1460 EAERLRRQVQDESQRKRQAEAELALRvkaeaeaAREKQRALQALDELRlQAEEAERRLR 1518
Cdd:pfam02029  281 KREERRKILEEEEQRRKQEEAERKAR-------EEEEKRRMKEEIERR-RAEAAEKRQK 331
Smc COG1196
Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];
2233-2650 8.26e-05

Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 224117 [Multi-domain]  Cd Length: 1163  Bit Score: 48.94  E-value: 8.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2233 EEAE-KMKQVAEEAARLSVAAQEaaRLRQLaeEDLAQQRALAEKMLKekmqavQEATRLKAEAELLQQQKELAQEQARRL 2311
Cdd:COG1196   175 EEAErKLERTEENLERLEDLLEE--LEKQL--EKLERQAEKAERYQE------LKAELRELELALLLAKLKELRKELEEL 244
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2312 QEDKEQMaqqlveetqgfQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIgeklhrtelaTQE 2391
Cdd:COG1196   245 EEELSRL-----------EEELEELQEELEEAEKEIEELKSELEELREELEELQEELLELKEEIEEL----------EGE 303
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2392 KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLkqEAKLLQLKSEEMQTVQQEQILQETQALQKSFLSEKDSLLQRE 2471
Cdd:COG1196   304 ISLLRERLEELENELEELEERLEELKEKIEALKEEL--EERETLLEELEQLLAELEEAKEELEEKLSALLEELEELFEAL 381
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2472 RfieqekakleqlfqdevakakqlreeqqrqqqqmeqekqelmASMEEARRRQREAEEGVRRKQEELQHLEQQRQQQEKL 2551
Cdd:COG1196   382 R------------------------------------------EELAELEAELAEIRNELEELKREIESLEERLERLSER 419
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2552 LAEENQRLRERLQRLEEEHRAALAHSEIATTQAASTKALPNGRDApdgpsVEAEPEYTFEGLRQKVPAQQLQEAGILSQE 2631
Cdd:COG1196   420 LEDLKEELKELEAELEELQTELEELNEELEELEEQLEELRDRLKE-----LERELAELQEELQRLEKELSSLEARLDRLE 494
                         410
                  ....*....|....*....
gi 254675251 2632 ELQRLAQGHTTVAELTQRE 2650
Cdd:COG1196   495 AEQRASQGVRAVLEALESG 513
mukB PRK04863
chromosome partition protein MukB;
1311-2029 8.53e-05

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 49.19  E-value: 8.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1311 EEERLAEQQR----AEERERLAEVEAALEKQRQLAEAHaQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEE 1386
Cdd:PRK04863  299 RRQLAAEQYRlvemARELAELNEAESDLEQDYQAASDH-LNLVQTALRQQEKIERYQADLEELEERLEEQNEVVEEADEQ 377
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1387 LQHLR-QSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQ-----LETTERQRGGAEGELQALRARAEEAEAQKRQAQEE 1460
Cdd:PRK04863  378 QEENEaRAEAAEEEVDELKSQLADYQQALDVQQTRAIQYQqavqaLERAKQLCGLPDLTADNAEDWLEEFQAKEQEATEE 457
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1461 AERLRRQVQDESQRKRQAE--AELALRVKAEAEAAREKQRALQALDELRLQAEEAER----RLRQAEAERARQVQVALET 1534
Cdd:PRK04863  458 LLSLEQKLSVAQAAHSQFEqaYQLVRKIAGEVSRSEAWDVARELLRRLREQRHLAEQlqqlRMRLSELEQRLRQQQRAER 537
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1535 AQRSAEVELQSK--RASFAEK-TAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWqLKANEALRlRL 1611
Cdd:PRK04863  538 LLAEFCKRLGKNldDEDELEQlQEELEARLESLSESVSEARERRMALRQQLEQLQARIQRLAARAPAW-LAAQDALA-RL 615
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1612 QAEEVAQQKSLAQADAEKQKEEAERearrrgKAEEQAVRQRELAEQELEKQ-RQLaegtaQQRLAAEQELIRLRAETEQG 1690
Cdd:PRK04863  616 REQSGEEFEDSQDVTEYMQQLLERE------RELTVERDELAARKQALDEEiERL-----SQPGGSEDPRLNALAERFGG 684
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1691 EQQRQL-----LEEE------LARLQH--------EATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSK 1751
Cdd:PRK04863  685 VLLSEIyddvsLEDApyfsalYGPARHaivvpdlsDAAEQLAGLEDCPEDLYLIEGDPDSFDDSVFSVEELEKAVVVKIA 764
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1752 QRlEAEAGRFRE--LAEEAARlRALAEEAKRQRQLAEEDAARQRAEAERVLT-----EKLAAISEATRLKTEAEIALKEK 1824
Cdd:PRK04863  765 DR-QWRYSRFPEvpLFGRAAR-EKRIEQLRAEREELAERYATLSFDVQKLQRlhqafSRFIGSHLAVAFEADPEAELRQL 842
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1825 EAE-NERLRRLAEDEAfqrrrLEEQAALHKADIEERLAQLRK-ASESELerqkgLVEDTLRQR-RQVEEEIMALkvsfEK 1901
Cdd:PRK04863  843 NRRrVELERALADHES-----QEQQQRSQLEQAKEGLSALNRlLPRLNL-----LADETLADRvEEIREQLDEA----EE 908
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1902 AAA-----GKA--ELELELGRIRSNAEDTMRSKEQaeLEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVAlE 1974
Cdd:PRK04863  909 AKRfvqqhGNAlaQLEPIVSVLQSDPEQFEQLKQD--YQQAQQTQRDAKQQAFALTEVVQRRAHFSYEDAAEMLAKNS-D 985
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1975 EVERLKAKVEEARRLRERA-EQESARQLQLAQ-------------------EAAQKRLQ---------AEEKA------- 2018
Cdd:PRK04863  986 LNEKLRQRLEQAEQERTRArEQLRQAQAQLAQynqvlaslkssydakrqmlQELKQELQdlgvpadsgAEERArarrdel 1065
                         810
                  ....*....|...
gi 254675251 2019 HAFVV--QQREEE 2029
Cdd:PRK04863 1066 HARLSanRSRRNQ 1078
Caldesmon pfam02029
Caldesmon;
1645-1944 9.11e-05

Caldesmon;


Pssm-ID: 426572 [Multi-domain]  Cd Length: 490  Bit Score: 48.33  E-value: 9.11e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1645 EEQAVRQREL-AEQELEKQRQLAEGTAQQR--------LAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKR 1715
Cdd:pfam02029    3 EEEAARERRRrAREERRRQKESEEPSSQEDsqpevnaqEEAEEEDSELKPSGQGGLDEEEAFLDRTAKREERRQKRLQEA 82
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1716 QELEAELAKVRAEMEVLLASKARAEEESRSTSEKsKQRLEAEAGRfRELAEEAARLRALAEEAKRQRQLAEEDAARQRAE 1795
Cdd:pfam02029   83 LERQKELDPTITDEQASKPRSTENTPEEKNNTEE-EEKSSTRKER-YEIEEREVSEKSYEKDDKKAVPKEEEEEEDAKTE 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1796 AERVLTEKlaaisEATRLKTEAEIALKEKEAE--NERLRRLAEDEAFQRRRLEEQAALHKADIEER-------LAQLRKA 1866
Cdd:pfam02029  161 EEEEEEEE-----EKKVSKKKKEKLKDEYTSKvfLDQKKGHPEQKSQNGALEEVTSMTVKLKRTERtfsqkslVAEDEEE 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1867 SESELERQKGLVEdtLRQRRQVEEeimalKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQAEL--EAARQRQLAAEE 1944
Cdd:pfam02029  236 GAAFLEAEQKLEE--LRRRRQEKE-----SQEFEKLRQKQQEAELELEELKKKREERRKILEEEEQrrKQEEAERKAREE 308
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1759-2005 9.53e-05

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 429718 [Multi-domain]  Cd Length: 488  Bit Score: 48.34  E-value: 9.53e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1759 GRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRRLAEDE 1838
Cdd:pfam07888   34 NRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKVEELEEKYKELSRSGEEL 113
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1839 AFQRRRLEEQAALHKADIEE------RLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAELELE 1912
Cdd:pfam07888  114 AEEKDALLAQRAESEARIREleedikTLTQRVLERETELERMKERVKKAGAQRKEEEAERKQLQAKLQQTEEELRSLSKE 193
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1913 LGRIRSNAEDTMRSKEQAELEAARQRQLaaeeeQRRREAEERVQRSLAAEEEAARQRKVALEE-VERLKAKVEEARRLRE 1991
Cdd:pfam07888  194 FQELRNSLAQRDTQVLQLQDTITTLTQK-----LTTAHRKEAENEALLEELRSLQERLNASERkVEGLGEELSSMAAQRD 268
                          250
                   ....*....|....*
gi 254675251  1992 RAEQESAR-QLQLAQ 2005
Cdd:pfam07888  269 RTQAELHQaRLQAAQ 283
CH_jitterbug-like_rpt3 cd21185
third calponin homology (CH) domain found in Drosophila melanogaster protein jitterbug and ...
149-226 1.04e-04

third calponin homology (CH) domain found in Drosophila melanogaster protein jitterbug and similar proteins; Protein jitterbug (Jbug) is an actin-meshwork organizing protein. It is required to maintain the shape and cell orientation of the Drosophila notum epithelium during flight muscle attachment to tendon cells. Jbug contains three copies of the CH domain. This model corresponds to the third CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409034  Cd Length: 98  Bit Score: 44.22  E-value: 1.04e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251  149 DNFTTSWRDGRLFNAIIHRHKPMLIDMNKVYRQTNLENLDQAFSVAERdLGVTRLLDPEDVDVPQPDEKSIITYVSSL 226
Cdd:cd21185    20 NNFTTDWNDGRLLCGLVNALGGSVPGWPNLDPEESENNIQRGLEAGKS-LGVEPVLTAEEMADPEVEHLGIMAYAAQL 96
PLEC smart00250
Plectin repeat;
3648-3684 1.04e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 42.08  E-value: 1.04e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3648 RYLYGTGAVAGVYLPGSRQTLTIYQALKKGLLSAEVA 3684
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
HCR pfam07111
Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha ...
2144-2575 1.10e-04

Alpha helical coiled-coil rod protein (HCR); This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation.


Pssm-ID: 284517 [Multi-domain]  Cd Length: 749  Bit Score: 48.59  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2144 RQKAQVEQELTTLRLQLEETDHQ---KSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALI 2220
Cdd:pfam07111  190 KQLAEAQKEAELLRKQLSKTQEEleaQVTLVESLRKYVGEQVPPEVHSQTWELERQELLDTMQHLQEDRADLQATVELLQ 269
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2221 LRDKDNTQRFLEEEAEKMKQVAEEAarlSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAE-AELLQQ 2299
Cdd:pfam07111  270 VRVQSLTHMLALQEEELTRKIQPSD---SLEPEFPKKCRSLLNRWREKVFALMVQLKAQDLEHRDSVKQLRGQvAELQEQ 346
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2300 QKELAQEQARRLQEDKEQMAQQLVEE--TQGFQ----RTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRK 2373
Cdd:pfam07111  347 VTSQSQEQAILQRALQDKAAEVEVERmsAKGLQmelsRAQEARRRQQQQTASAEEQLKFVVNAMSSTQIWLETTMTRVEQ 426
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2374 QAEEIG----------EKLHRTELATQEKVTLVQTleiqRQQSDHDAERLREAIAELEREKEKLKQEAKLL--------- 2434
Cdd:pfam07111  427 AVARIPslsnrlsyavRKVHTIKGLMARKVALAQL----RQESCPPPPPAPPVDADLSLELEQLREERNRLdaelqlsah 502
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2435 -----------QLKSEEMQTV----QQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQ-LFQDEVAKAKQLREE 2498
Cdd:pfam07111  503 liqqevgrareQGEAERQQLSevaqQLEQELQRAQESLASVGQQLEVARQGQQESTEEAASLRQeLTQQQEIYGQALQEK 582
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2499 QQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRKQ----EELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAAL 2574
Cdd:pfam07111  583 VAEVETRLREQLSDTKRRLNEARREQAKAVVSLRQIQhratQEKERNQELRRLQDEARKEEGQRLARRVQELERDKNLML 662

                   .
gi 254675251  2575 A 2575
Cdd:pfam07111  663 A 663
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1506-1812 1.14e-04

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 225177 [Multi-domain]  Cd Length: 548  Bit Score: 48.29  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1506 LRLQAEEAERRlRQAEAERARQVQVALETAQRSA-EVELQSKRAsfaEKTAQLERTLQEEHVTVAQLREEAERRAQQQAE 1584
Cdd:COG2268   213 RRRIAQVLQDA-EIAENEAEKETEIAIAEANRDAkLVELEVEQQ---PAGKTAEQTREVKIILAETEAEVAAWKAETRRE 288
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1585 AERAreeaerelerwqlkanealrlRLQAEEVAQQKSlAQADAEKQKEEAEREARRRGKAEEQAVRQrELAEQELEKQRQ 1664
Cdd:COG2268   289 AEQA---------------------EILAEQAIQEEK-AQAEQEVQHAKALEAREMRVGLIERQKET-ELEPQERSYFIN 345
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1665 LAEGTAQ-QRLAAEQELIRLRAETEQGEQ-QRQLLEEELArlqhEATAATQKRQELEAELAKVRAEMEvllaskaraEEE 1742
Cdd:COG2268   346 AAQRQAQeEAKAAANIAEAIGAQAEAAVEtARETEEAERA----EQAALVAAAEAAEQEQVEIAVRAE---------AAK 412
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1743 SRSTSEKSKQRLEAEAGRFRELAeEAARLRALAEEakrQRQLAEEDAARQRAEAERVLTEKLAAISEATR 1812
Cdd:COG2268   413 AEAEAQAAEIKAEAEAIREKGKA-EAEAKRALAEA---IQVLGDAAAAELFKALVQALPEVAEEAAQPMK 478
CH_PLS_rpt1 cd21292
first calponin homology (CH) domain found in the plastin family; The plastin family includes ...
12-109 1.15e-04

first calponin homology (CH) domain found in the plastin family; The plastin family includes plastin-1, -2, and -3, which are all actin-bundling proteins. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, LC64P, or lymphocyte cytosolic protein 1 (LCP-1), plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Members of this family contain four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409141  Cd Length: 145  Bit Score: 45.35  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   12 QKKTFTKWVN---------KHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR----EKGRMRFHKLQNVQIALDYL 78
Cdd:cd21292    25 EKVAFVNWINknlgddpdcKHLLPMDPNTDDLFEKVKDGILLCKMINLSVPDTIDErainKKKLTVFTIHENLTLALNSA 104
                          90       100       110
                  ....*....|....*....|....*....|.
gi 254675251   79 RHRQVKLVNIRNDDIADGNPKLTLGLIWTII 109
Cdd:cd21292   105 SAIGCNVVNIGAEDLKEGKPHLVLGLLWQII 135
FimV COG3170
Tfp pilus assembly protein FimV [Cell motility, Extracellular structures];
1315-1539 1.21e-04

Tfp pilus assembly protein FimV [Cell motility, Extracellular structures];


Pssm-ID: 225711 [Multi-domain]  Cd Length: 755  Bit Score: 48.37  E-value: 1.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1315 LAEQQRAEERERLAEVEA-----ALEKQRQLAEAHAQAKAQA----ELEAQELQRRMQEEVARreeaavdaqqqkrsiQE 1385
Cdd:COG3170   248 AAQILRESPQEALAEVKAqtaafAGEPSKADRVGKPVAKAPAkvakERALAELPARVAELQAQ---------------LN 312
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1386 ELQHlrqsseaEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAE-GELQALRARAEEAEAQKRQAQEEAERL 1464
Cdd:COG3170   313 KAQH-------ELAQKAAPLAAAQAALDAPAETATAPSAPAPQVSAESSPAQpGSYLLAAPGDAPLGELAQAQSARERLA 385
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 1465 RRQVQDESQRKRQAEAELALRVKAEAEA-AREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSA 1539
Cdd:COG3170   386 EESVPAAEPRSRLAPVAAVEQPFAEVESpLSSLPAPLLALGLVALDGGWLVLRRAQQPPVETQGFQNRLLNRADTL 461
PLEC smart00250
Plectin repeat;
3930-3964 1.34e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.70  E-value: 1.34e-04
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 254675251   3930 LLEAQAATGYVIDPIKGLKLTVEEAVRMGIVGPEF 3964
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPET 37
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
2146-2573 1.38e-04

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 48.11  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2146 KAQVEQ-ELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEaENRALILRDK 2224
Cdd:PRK02224  193 KAQIEEkEEKDLHERLNGLESELAELDEEIERYEEQREQARETRDEADEVLEEHEERREELETLEAEIE-DLRETIAETE 271
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2225 DNTQRFLEEEAEKMKQVAEEAARLSVAAQEAArLRQLAEEDLAQQRALAEKMLKEKMQAVQE----ATRLKAEAELLQQQ 2300
Cdd:PRK02224  272 REREELAEEVRDLRERLEELEEERDDLLAEAG-LDDADAEAVEARREELEDRDEELRDRLEEcrvaAQAHNEEAESLRED 350
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2301 KELAQEQARRLQEDkeqmAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGE 2380
Cdd:PRK02224  351 ADDLEERAEELREE----AAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREERDELRE 426
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2381 KLH--RTELAT-QEKVTLVQTL-----------EIQRQQSDHDAERLREAIAELEREKEKLKQ-----EAKLLQLKSEEM 2441
Cdd:PRK02224  427 REAelEATLRTaRERVEEAEALleagkcpecgqPVEGSPHVETIEEDRERVEELEAELEDLEEeveevEERLERAEDLVE 506
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2442 QTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQ---EKAKLEQLFQD--EVAKAKQLREEQQRQQQQMEQEKQELMAS 2516
Cdd:PRK02224  507 AEDRIERLEERREDLEELIAERRETIEEKRERAEElreRAAELEAEAEEkrEAAAEAEEEAEEAREEVAELNSKLAELKE 586
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2517 MEEARRRQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQR---LEEEHRAA 2573
Cdd:PRK02224  587 RIESLERIRTLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERkreLEAEFDEA 646
Crescentin pfam19220
Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament ...
2122-2424 1.45e-04

Crescentin protein; This entry represents a bacterial equivalent to Intermediate Filament proteins, named crescentin, whose cytoskeletal function is required for the vibrioid and helical shapes of Caulobacter crescentus. Without crescentin, the cells adopt a straight-rod morphology. Crescentin has characteristic features of IF proteins including the ability to assemble into filaments in vitro without energy or cofactor requirements. In vivo, crescentin forms a helical structure that colocalizes with the inner cell curvatures beneath the cytoplasmic membrane.


Pssm-ID: 437057 [Multi-domain]  Cd Length: 401  Bit Score: 47.75  E-value: 1.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2122 LKQKQAADAEMEKHkkfAEQTLRQKAQVEQELTTLRLQLEETDHQksildeeLQRLKAEVTEAARQRSQVEEELFSVRVQ 2201
Cdd:pfam19220  113 LRDKTAQAEALERQ---LAAETEQNRALEEENKALREEAQAAEKA-------LQRAEGELATARERLALLEQENRRLQAL 182
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2202 MEELGKLKARIEAENRALILRDKDNTQRFLEEEAEkmkqvaeeaarlsVAAQEAARLRQLAEEDLAQQRALAEKM-LKEK 2280
Cdd:pfam19220  183 SEEQAAELAELTRRLAELETQLDATRARLRALEGQ-------------LAAEQAERERAEAQLEEAVEAHRAERAsLRMK 249
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2281 MQAVQeaTRLKAEAELLQQQKELAQEQARRLQEdKEQMAQQLVEETQGFQRT---LEAERQRQLEMSAEAERLKLRMAEM 2357
Cdd:pfam19220  250 LEALT--ARAAATEQLLAEARNQLRDRDEAIRA-AERRLKEASIERDTLERRlagLEADLERRTQQFQEMQRARAELEER 326
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251  2358 SRAQARAEEDAQRFRKQAEEIGEKLhrtelatQEKV-TLVQTLEIQRQQSDHDAERLREaiaELEREK 2424
Cdd:pfam19220  327 AEMLTKALAAKDAALERAEERIASL-------SDRIaELTKRFEVERAALEQANRRLKE---ELQRER 384
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
2293-2578 1.54e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 47.81  E-value: 1.54e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2293 EAELLQQQKELAQEQA----RRLQEDKEQMAQQLVEETQGfQRTLEAERQRQLEMS-----AEAERLKLRMAEMSRAQAR 2363
Cdd:pfam17380  267 ENEFLNQLLHIVQHQKavseRQQQEKFEKMEQERLRQEKE-EKAREVERRRKLEEAekarqAEMDRQAAIYAEQERMAME 345
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2364 AEEDAQRFRKQAEEI-GEKLHRTELATQ-EKVTLVQTLEIQRQQSDhdaERLREAIAELEREKEKLKQEAKLLQLKSEEM 2441
Cdd:pfam17380  346 RERELERIRQEERKReLERIRQEEIAMEiSRMRELERLQMERQQKN---ERVRQELEAARKVKILEEERQRKIQQQKVEM 422
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2442 QTVQQEQILQETQALQKsflsekdslLQRERFIEQEKAKLEQLfqdevakakqlreeqqRqqqqmEQEKQELMASMEEAR 2521
Cdd:pfam17380  423 EQIRAEQEEARQREVRR---------LEEERAREMERVRLEEQ----------------E-----RQQQVERLRQQEEER 472
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675251  2522 RRQREAEEGVRRKQ----EELQHLEQQRQQQEKLLAEENQRLRERLQRLEEEHRAALAHSE 2578
Cdd:pfam17380  473 KRKKLELEKEKRDRkraeEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAIYEEE 533
PLEC smart00250
Plectin repeat;
3724-3760 1.60e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.70  E-value: 1.60e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   3724 RLLSAERAVTGYRDPYTEQTISLFQAMKKELIPAEEA 3760
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1181-1524 1.68e-04

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 429718 [Multi-domain]  Cd Length: 488  Bit Score: 47.57  E-value: 1.68e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1181 ADPLSAWLQDAKR-RQEQIQAVPIANCQAAREQLRQEKALLEEIERHGE---KVEECQKFAKQYINAIKDYELQLITYKA 1256
Cdd:pfam07888   29 AELLQNRLEECLQeRAELLQAQEAANRQREKEKERYKRDREQWERQRRElesRVAELKEELRQSREKVEELEEKYKELSR 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1257 QLEPVAspAKKP---KVQSGSESVIQEYVDlrtrysELTTLTSQYIKFISETLRRMEEEERLAEQQRAEERER---LAEV 1330
Cdd:pfam07888  109 SGEELA--EEKDallAQRAESEARIRELEE------DIKTLTQRVLERETELERMKERVKKAGAQRKEEEAERkqlQAKL 180
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1331 EAALEKQRQLAEAHAQAK-AQAELEAQELQrrMQEEVARREEAAVDAQQ---QKRSIQEELQHLRQ---SSEAEIQAKAQ 1403
Cdd:pfam07888  181 QQTEEELRSLSKEFQELRnSLAQRDTQVLQ--LQDTITTLTQKLTTAHRkeaENEALLEELRSLQErlnASERKVEGLGE 258
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1404 QVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRAR-AEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAEL 1482
Cdd:pfam07888  259 ELSSMAAQRDRTQAELHQARLQAAQLTLQLADASLALREGRARwAQERETLQQSAEADKDRIEKLSAELQRLEERLQEER 338
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 254675251  1483 ALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAER 1524
Cdd:pfam07888  339 MEREKLEVELGREKDCNRVQLSESRRELQELKASLRVAQKEK 380
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
1066-1285 1.74e-04

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 47.71  E-value: 1.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1066 AEEVLKTHEEQLKEAQAvpatlqELEATKASLKKLRAQAEAQQPVFNTLRDELRGAQEVGERLQQRHGERDVEVERWRER 1145
Cdd:COG4372    86 LRTELGTAQGEKRAAET------EREAARSELQKARQEREAVRQELAAARQNLAKAQQELARLTKQAQDLQTRLKTLAEQ 159
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1146 VTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAVP--IANCQAAREQLRQekalleEI 1223
Cdd:COG4372   160 RRQLEAQAQSLQASQKQLQASATQLKSQVLDLKLRSAQIEQEAQNLATRANAAQARTeeLARRAAAAQQTAQ------AI 233
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675251 1224 ERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLepvaspAKKPKVQSGSESVIQEYVDLR 1285
Cdd:COG4372   234 QQRDAQISQKAQQIAARAEQIRERERQLQRLETAQ------ARLEQEVAQLEAYYQAYVRLR 289
PLEC smart00250
Plectin repeat;
4239-4272 1.82e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 41.31  E-value: 1.82e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 254675251   4239 EETGPVAGILDTETLEKVSITEAMHRNLVDNITG 4272
Cdd:smart00250    5 EAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
2143-2481 1.82e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 435022 [Multi-domain]  Cd Length: 1112  Bit Score: 47.79  E-value: 1.82e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2143 LRQKAQVEQELTTLRLQLEETDHQKSILDEELQR----LKAEVTEAARQRSQVEEELFSVRVQMEelgKLKARIEAENRA 2218
Cdd:pfam15921  316 MRQLSDLESTVSQLRSELREAKRMYEDKIEELEKqlvlANSELTEARTERDQFSQESGNLDDQLQ---KLLADLHKREKE 392
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2219 LILrDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLaeedLAQQRALAEKMLKEKMQAVQeatrlkAEAELLQ 2298
Cdd:pfam15921  393 LSL-EKEQNKRLWDRDTGNSITIDHLRRELDDRNMEVQRLEAL----LKAMKSECQGQMERQMAAIQ------GKNESLE 461
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2299 QQKELAQEQarrlqEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSA---EAER-LKLRMAEMSRAQARAEEDAQRFRKQ 2374
Cdd:pfam15921  462 KVSSLTAQL-----ESTKEMLRKVVEELTAKKMTLESSERTVSDLTAslqEKERaIEATNAEITKLRSRVDLKLQELQHL 536
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2375 AEEiGEKLHRTElatqekvTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQI--LQE 2452
Cdd:pfam15921  537 KNE-GDHLRNVQ-------TECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRleLQE 608
                          330       340
                   ....*....|....*....|....*....
gi 254675251  2453 TQALQKSFLSEKDSLLQRERFIEQEKAKL 2481
Cdd:pfam15921  609 FKILKDKKDAKIRELEARVSDLELEKVKL 637
ERM pfam00769
Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at ...
1304-1388 2.09e-04

Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at their amino terminus. This family represents the rest of these proteins.


Pssm-ID: 425860 [Multi-domain]  Cd Length: 247  Bit Score: 46.09  E-value: 2.09e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1304 ETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAE---LEAQELQRRMQEEVARREEAAVDAQQQK 1380
Cdd:pfam00769   34 ETAELLEEKLRVAEEEAELLEQKAQEAEEEKERLEESAEMEAEEKEQLErelREAQEEVARLEEESERKEEEAERLQEEL 113

                   ....*...
gi 254675251  1381 RSIQEELQ 1388
Cdd:pfam00769  114 EEAREEEE 121
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
2126-2582 2.24e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 47.66  E-value: 2.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2126 QAADAEMEKHKKFAEQTLRQKAQVEQElTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEEL 2205
Cdd:TIGR00618  348 QTLHSQEIHIRDAHEVATSIREISCQQ-HTLTQHIHTLQQQKTTLTQKLQSLCKELDILQREQATIDTRTSAFRDLQGQL 426
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2206 GKLKARIEAEnralilrdkdntQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQ 2285
Cdd:TIGR00618  427 AHAKKQQELQ------------QRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLA 494
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2286 EATRLKAEAELLQQQkELAQEQAR----------RLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMA 2355
Cdd:TIGR00618  495 RLLELQEEPCPLCGS-CIHPNPARqdidnpgpltRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSFS 573
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2356 EMSRAQARAEEDAQRFRKQAEEIgekLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQ 2435
Cdd:TIGR00618  574 ILTQCDNRSKEDIPNLQNITVRL---QDLTEKLSEAEDMLACEQHALLRKLQPEQDLQDVRLHLQQCSQELALKLTALHA 650
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2436 LKSEEMQ----------TVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQ 2505
Cdd:TIGR00618  651 LQLTLTQervrehalsiRVLPKELLASRQLALQKMQSEKEQLTYWKEMLAQCQTLLRELETHIEEYDREFNEIENASSSL 730
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2506 MEQEKQELMA---SMEEARRRQRE-----AEEGVRRKQE---------ELQHLEQQRQQQEKLLAEENQRLRErlqrLEE 2568
Cdd:TIGR00618  731 GSDLAAREDAlnqSLKELMHQARTvlkarTEAHFNNNEEvtaalqtgaELSHLAAEIQFFNRLREEDTHLLKT----LEA 806
                          490
                   ....*....|....
gi 254675251  2569 EHRAALAHSEIATT 2582
Cdd:TIGR00618  807 EIGQEIPSDEDILN 820
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
2104-2355 2.37e-04

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 47.33  E-value: 2.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2104 RKeaeqeaarraqaeqaalkqkqAADAEMEKhkkfaeqTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTE 2183
Cdd:COG4372   104 RE---------------------AARSELQK-------ARQEREAVRQELAAARQNLAKAQQELARLTKQAQDLQTRLKT 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2184 AARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQ--RFLEEEAEKMKQVAEEAARLSVAAQE-AARLRQ 2260
Cdd:COG4372   156 LAEQRRQLEAQAQSLQASQKQLQASATQLKSQVLDLKLRSAQIEQeaQNLATRANAAQARTEELARRAAAAQQtAQAIQQ 235
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2261 LAEEdlAQQRALAekmLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQ 2340
Cdd:COG4372   236 RDAQ--ISQKAQQ---IAARAEQIRERERQLQRLETAQARLEQEVAQLEAYYQAYVRLRQQAAATQRGQVLAGAAQRVAQ 310
                         250
                  ....*....|....*
gi 254675251 2341 LEMSAEAERLKLRMA 2355
Cdd:COG4372   311 AQAQAQAQAQLLSSA 325
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1679-1992 2.53e-04

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 428520 [Multi-domain]  Cd Length: 660  Bit Score: 47.42  E-value: 2.53e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1679 ELIRLRAETEQGEQQ--RQLLEEELARLQHEATAATQKRQeLEAELAKVRA---EMEVLLASKARAEEESRSTSEKSKQR 1753
Cdd:pfam05557    3 ELIESKARLSQLQNEkkQMELEHKRARIELERKASALARQ-LERESDRNQElqkRIRLLEKREAEAEEALREQAELNRLK 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1754 LEAEAGRFRELAEEAARLRALAE----------EAKRQRQLAEEDAARQRAEAERV---LTEKLAAISEATRLKTEAEIA 1820
Cdd:pfam05557   82 KKNLEALNKKLNEKESQLADAREvisclknelsELRRQIQRQELELSSTNSELEELqerLDLQKAKAQEAEQLRQNLEAQ 161
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1821 LKEKEAENERLRRLAedeafQRRRLEEQAALHKADIEERLAQLRKAsESELERQKGLVE---DTLRQRRQVEEEIMALKV 1897
Cdd:pfam05557  162 QSSLAEAEQRIKELE-----FEIQSQEQDSEIVKNSKSELARIPEL-ERELERLREHNKhlnENIENKLLLKEEVEDLKR 235
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1898 S---FEKAAAGKAELELELGRIRS----------NAEDTMRSKE--QAELEAARQRQLAAEEEQRRREAEERVQRSLAAE 1962
Cdd:pfam05557  236 KlerEEGYREELATLELEKEKLEQelksweklaqDTGLNLRSPEdlSRRIEQLQQREITLKEENSSLTSSARQLEKAQRE 315
                          330       340       350
                   ....*....|....*....|....*....|..
gi 254675251  1963 --EEAARQRKVALEEVERLKAKVEEARRLRER 1992
Cdd:pfam05557  316 leQELAQYLKNIEDLNKKLKRHKALVRRLQRR 347
PRK12704 PRK12704
phosphodiesterase; Provisional
1744-1892 2.72e-04

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 47.08  E-value: 2.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1744 RSTSEKSKQRLEAEAGRFRELAEEAArlralaEEAKRQRQL-AEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALK 1822
Cdd:PRK12704   26 KKIAEAKIKEAEEEAKRILEEAKKEA------EAIKKEALLeAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLD 99
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 254675251 1823 EKEAENERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKasesELERQKGLVEDTLRQR--RQVEEEI 1892
Cdd:PRK12704  100 RKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIEEQLQ----ELERISGLTAEEAKEIllEKVEEEA 167
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
2142-2374 2.79e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 46.38  E-value: 2.79e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2142 TLRQKAQVEQELTTLRLQleetdhQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALIL 2221
Cdd:TIGR02794   41 VLVDPGAVAQQANRIQQQ------KKPAAKKEQERQKKLEQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQA 114
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2222 RDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARlrQLAEEDLAQQRALAEKMLKE-KMQAVQEA-----TRLKAEAE 2295
Cdd:TIGR02794  115 EEKQKQAEEAKAKQAAEAKAKAEAEAERKAKEEAAK--QAEEEAKAKAAAEAKKKAEEaKKKAEAEAkakaeAEAKAKAE 192
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251  2296 LLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQ 2374
Cdd:TIGR02794  193 EAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAERKADEAELGDIFGLASGSNAEKQGGARGAAAGSEVDKYAAIIQQA 271
Golgin_A5 pfam09787
Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining ...
1437-1571 2.85e-04

Golgin subfamily A member 5; Members of this family of proteins are involved in maintaining Golgi structure. They stimulate the formation of Golgi stacks and ribbons, and are involved in intra-Golgi retrograde transport. Two main interactions have been characterized: one with RAB1A that has been activated by GTP-binding and another with isoform CASP of CUTL1.


Pssm-ID: 430825 [Multi-domain]  Cd Length: 305  Bit Score: 46.27  E-value: 2.85e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1437 EGELQALRARAEEAEAQkrqAQEEAERLRRQVQDesqRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERR 1516
Cdd:pfam09787   67 NQQIEQLRTELQELEAQ---QQEEAESSREQLQD---LEEQLATERQARREAEAELERLQEELRYLEEELRRTKATLQSR 140
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1517 LRQAEAERARQ-VQVALETAQRSAEVELQSK----RASFAEKTAQLERTLQEEHVTVAQL 1571
Cdd:pfam09787  141 IKDREAEIEKLrNQLTNKSQSSSSQSELENRlhqlTESLIQKQTMLEALSTEKNSLVLQL 200
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
1643-1866 3.00e-04

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 46.86  E-value: 3.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1643 KAEE--------QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQK 1714
Cdd:PRK05035  447 KAEEakarfearQARLEREKAAREARHKKAAEARAAKDKDAVAAALARVKAKKAAATQPIVIKAGARPDNSAVIAAREAR 526
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1715 RQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAE-EAKRQRQLAEEDAARQR 1793
Cdd:PRK05035  527 KAQARARQAEKQAAAAADPKKAAVAAAIARAKAKKAAQQAANAEAEEEVDPKKAAVAAAIARaKAKKAAQQAASAEPEEQ 606
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251 1794 AEAERVLTEKL-AAISEATRLKTEAEIALKEKEAENERLRRLAEDEAFQRRRLEEQAAlhKADIEERLAQLRKA 1866
Cdd:PRK05035  607 VAEVDPKKAAVaAAIARAKAKKAEQQANAEPEEPVDPRKAAVAAAIARAKARKAAQQQ--ANAEPEEAEDPKKA 678
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
1734-1933 3.02e-04

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 46.72  E-value: 3.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1734 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQrqlaEEDAARQRAEAERVLTEKLAAISEATRL 1813
Cdd:PRK09510   72 KSAKRAEEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQ----AEEAAKQAALKQKQAEEAAAKAAAAAKA 147
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1814 KTEAEIALKEKEAENerlrrlAEDEAfQRRRLEEQAALHKADIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIM 1893
Cdd:PRK09510  148 KAEAEAKRAAAAAKK------AAAEA-KKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAA 220
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 254675251 1894 ALKVSFEKAAAGKAELELELGRIRSNAEDTMRSKEQAELE 1933
Cdd:PRK09510  221 AEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEVD 260
YhaN COG4717
Uncharacterized protein YhaN, contains AAA domain [Function unknown];
2195-2486 3.10e-04

Uncharacterized protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 227061 [Multi-domain]  Cd Length: 984  Bit Score: 47.15  E-value: 3.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2195 LFSVRVQMEELGKLKARIEAENRALILRDKDNTQrfLEEEAEKMKQvaeEAARLSVAAQEAARLRQLAEEDLAQQRALAE 2274
Cdd:COG4717   149 LFSGTSGSPASTKLLEVLNKEADSLYKPSGRNPQ--INQLLEKLKQ---ERNEIDEAEKEYATYHKLLESRRAEHARLAE 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2275 KM--LKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQgfqrtLEAERQRQlemSAEAERLKL 2352
Cdd:COG4717   224 LRseLRADRDHIRALRDAVELWPRLQEWKQLEQELTRRREELATFPRDGVLRLEK-----REAHLQKT---EAEIDALLV 295
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2353 RMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTeLATQEKVTLVQTlEIQRQQSDHDAERLREAIAE---LEREKEKL-K 2428
Cdd:COG4717   296 RLAELKDLASQLIPAKEAVLQALVRLHQQLSEI-KASAFELTETLA-GIEADLRDKEEAAGNGFEAErvhDLRSLECMlR 373
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2429 QEAKLLQLKSEEMQTVQQ--EQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQ 2486
Cdd:COG4717   374 YQSSQRELKQTEAAYCKRldEKRLFEDEAEEEARQRLADDEEEVRAGDEAREEKIAANSQ 433
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
1347-1579 3.34e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227278 [Multi-domain]  Cd Length: 420  Bit Score: 46.64  E-value: 3.34e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1347 AKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLrqssEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQL 1426
Cdd:COG4942    28 AAAFSAAADDKQLKQIQKEIAALEKKIREQQDQRAKLEKQLKSL----ETEIASLEAQLIETADDLKKLRKQIADLNARL 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1427 ETTERQRGGAEGEL----QALRARAEEAEAQKRQAQEEAER-------LRRQVQDESQRKRQAEAELALRVKAEAEAARE 1495
Cdd:COG4942   104 NALEVQEREQRRRLaeqlAALQRSGRNPPPALLVSPEDAQRsvrlaiyYGALNPARAERIDALKATLKQLAAVRAEIAAE 183
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1496 KQRALQALDELRLQAEEAERrLRQAEAERARQVQVALETAQRSAEvELQSKRASFAEKTAQLERTLQEEHVTVAQLREEA 1575
Cdd:COG4942   184 QAELTTLLSEQRAQQAKLAQ-LLEERKKTLAQLNSELSADQKKLE-ELRANESRLKNEIASAEAAAAKAREAAAAAEAAA 261

                  ....
gi 254675251 1576 ERRA 1579
Cdd:COG4942   262 ARAR 265
PRK11281 PRK11281
mechanosensitive channel MscK;
2123-2327 3.62e-04

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 46.83  E-value: 3.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2123 KQKQAaDAEMEKHKKFAEQTLR---QKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQR----------S 2189
Cdd:PRK11281   50 KQKLL-EAEDKLVQQDLEQTLAlldKIDRQKEETEQLKQQLAQAPAKLRQAQAELEALKDDNDEETRETlstlslrqleS 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2190 QVEE-------------------------------ELFSVRVQMEELGKLKARIEAENRALI--LRDKDNT-QRFLEEEA 2235
Cdd:PRK11281  129 RLAQtldqlqnaqndlaeynsqlvslqtqperaqaALYANSQRLQQIRNLLKGGKVGGKALRpsQRVLLQAeQALLNAQN 208
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2236 EKMKQVAEEAARLSVAAQE-----AARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAElLQQQKELAQEQARR 2310
Cdd:PRK11281  209 DLQRKSLEGNTQLQDLLQKqrdylTARIQRLEHQLQLLQEAINSKRLTLSEKTVQEAQSQDEAAR-IQANPLVAQELEIN 287
                         250
                  ....*....|....*..
gi 254675251 2311 LqedkeQMAQQLVEETQ 2327
Cdd:PRK11281  288 L-----QLSQRLLKATE 299
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
1376-1577 3.99e-04

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 45.99  E-value: 3.99e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1376 AQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERsrmRIEEEIRVVRLqletteRQRGGAEGELQALRARAEEAEAQKR 1455
Cdd:TIGR02794   49 AQQANRIQQQKKPAAKKEQERQKKLEQQAEEAEKQ---RAAEQARQKEL------EQRAAAEKAAKQAEQAAKQAEEKQK 119
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1456 QAQEEAErlrrqvQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERrlrQAEAERArqvqvALETA 1535
Cdd:TIGR02794  120 QAEEAKA------KQAAEAKAKAEAEAERKAKEEAAKQAEEEAKAKAAAEAKKKAEEAKK---KAEAEAK-----AKAEA 185
                          170       180       190       200
                   ....*....|....*....|....*....|....*....|..
gi 254675251  1536 QRSAEVELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAER 1577
Cdd:TIGR02794  186 EAKAKAEEAKAKAEAAKAKAAAEAAAKAEAEAAAAAAAEAER 227
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1441-1680 4.14e-04

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 46.10  E-value: 4.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1441 QALRARAEEAEAQKrqAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRalqaldelrlQAEEAERRLRQA 1520
Cdd:COG3064    63 QYGRIQSQQSSAKK--GEQQRKKKEEQVAEELKPKQAAEQERLKQLEKERLKAQEQQK----------QAEEAEKQAQLE 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1521 EAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVAQlreeaerraqqqaeaerareeaerelERWQ 1600
Cdd:COG3064   131 QKQQEEQARKAAAEQKKKAEAAKAKAAAEAAKLKAAAEAKKKAEEAAKAA--------------------------EEAK 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1601 LKANEALRLRLQAEEVAqqKSLAQADAEKqKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQEL 1680
Cdd:COG3064   185 AKAEAAAAKKKAEAEAK--AAAEKAKAEA-EAKAKAEKKAEAAAEEKAAAEKKKAAAKAKADKAAAAAKAAERKAAAAAL 261
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
979-1472 4.18e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 46.64  E-value: 4.18e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   979 DPARECAQRIAEQQKAQAE-VEGLGKGVARLSAEAEKV-LALPEPSPAAPTLRSELELTLGKLEQVRSLSAIYLEKLK-- 1054
Cdd:pfam05483  264 EESRDKANQLEEKTKLQDEnLKELIEKKDHLTKELEDIkMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNka 343
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1055 --TISLVIR----STQGAEEVLKTHEEQLKEAQavpatlQELEATKASLKKLRAQAEAQQPVFNTLRDELrgaqevgERL 1128
Cdd:pfam05483  344 kaAHSFVVTefeaTTCSLEELLRTEQQRLEKNE------DQLKIITMELQKKSSELEEMTKFKNNKEVEL-------EEL 410
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1129 QQRHGERDV---EVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQL-------RYYRESADPLSAWLQDAKRRQEQI 1198
Cdd:pfam05483  411 KKILAEDEKlldEKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLtaiktseEHYLKEVEDLKTELEKEKLKNIEL 490
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1199 QAVPIANCQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAK------KPKVQS 1272
Cdd:pfam05483  491 TAHCDKLLLENKELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESVREEFIqkgdevKCKLDK 570
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1273 GSESVIQEYVDLRTRYSELTTLTS------QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQLAEAHA 1345
Cdd:pfam05483  571 SEENARSIEYEVLKKEKQMKILENkcnnlkKQIENKNKNIEELHQENKALKKKGSAENKQLNAYEIKVNKlELELASAKQ 650
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1346 QAKA-----QAELEAQEL-QRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRmriEEEI 1419
Cdd:pfam05483  651 KFEEiidnyQKEIEDKKIsEEKLLEEVEKAKAIADEAVKLQKEIDKRCQHKIAEMVALMEKHKHQYDKIIEER---DSEL 727
                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 254675251  1420 RVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES 1472
Cdd:pfam05483  728 GLYKNKEQEQSSAKAALEIELSNIKAELLSLKKQLEIEKEEKEKLKMEAKENT 780
TolC COG1538
Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];
1305-1543 4.42e-04

Outer membrane protein TolC [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 224455 [Multi-domain]  Cd Length: 457  Bit Score: 46.32  E-value: 4.42e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1305 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQ-AELEAQELQRRMQEEVARREEAAV----DAQQQ 1379
Cdd:COG1538   162 DLLAAQEQLALAEETLAAAEEQLELAEKRYDAGLATRLDVLQAEAQlASARAQLAAAQAQLAQARNALARLlglePGELL 241
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1380 KRSIQEELQHLRQSSEAEIQAKAQQ----VEAAERSRMRIEEEIRVVRLQL-----------ETTERQRGGAEGELQ--- 1441
Cdd:COG1538   242 DAPEPEALPALPPVLPDGLPSEALArrpdILAAEAQLAAANANIGAARAAFlptlsltasygRSSTNLSGLFGSSSRsws 321
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1442 -------------ALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDEL-- 1506
Cdd:COG1538   322 vgpglslpifdggRLRARVRQAEAQYDAALAQYEQTVLTARQEVADALAALEAALEQLQALRQAVEAAQEALELARERyq 401
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 254675251 1507 -----RLQAEEAERRLRQAEAErarqvQVALETAQRSAEVEL 1543
Cdd:COG1538   402 agvrtLLDVLDAQRTLLQARQA-----LLQARYDYLVALVNL 438
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
3649-3687 4.46e-04

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 40.40  E-value: 4.46e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 254675251  3649 YLYGTGAVAGVYLPGSRQTLTIYQALKKGLLSAEVARLL 3687
Cdd:pfam00681    1 LLEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
PRK12678 PRK12678
transcription termination factor Rho; Provisional
1305-1481 4.62e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 46.44  E-value: 4.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1305 TLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ---------LAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVD 1375
Cdd:PRK12678   45 GMRKGELIAAIKEARGGGAAAAAATPAAPAAAARRaaraaaaarQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEA 124
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1376 AQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEirvvrlqlETTERQRGGAEGELQALRARAEEAEAQKR 1455
Cdd:PRK12678  125 AQARERRERGEAARRGAARKAGEGGEQPATEARADAAERTEEE--------ERDERRRRGDREDRQAEAERGERGRREER 196
                         170       180
                  ....*....|....*....|....*.
gi 254675251 1456 QAQEEAERLRRQVQDESQRKRQAEAE 1481
Cdd:PRK12678  197 GRDGDDRDRRDRREQGDRREERGRRD 222
PRK10246 PRK10246
exonuclease subunit SbcC; Provisional
981-1673 4.65e-04

exonuclease subunit SbcC; Provisional


Pssm-ID: 182330 [Multi-domain]  Cd Length: 1047  Bit Score: 46.72  E-value: 4.65e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  981 ARECAQRIAEQQKAQAEVEGLGKGVARLSaeaekvLALPepspaAPTLRSELEltlGKLEQVRSLSAIyleKLKTISLVI 1060
Cdd:PRK10246  256 QQEASRRQQALQQALAAEEKAQPQLAALS------LAQP-----ARQLRPHWE---RIQEQSAALAHT---RQQIEEVNT 318
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1061 RSTQGAEEVLKTHEEQLKEAQAVPATLQELeatkaslkklrAQAEAQQPVFNTLRDELRG-----AQEVGERLQQRhger 1135
Cdd:PRK10246  319 RLQSTMALRARIRHHAAKQSAELQAQQQSL-----------NTWLAEHDRFRQWNNELAGwraqfSQQTSDREQLR---- 383
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1136 dveveRWRERVTQLLERWQAVLAQT-----DVRQRELEQLGRQlRYYRESADPLSAWLQDAKRRQEQIQAvpiANCQAAR 1210
Cdd:PRK10246  384 -----QWQQQLTHAEQKLNALPAITltltaDEVAAALAQHAEQ-RPLRQRLVALHGQIVPQQKRLAQLQV---AIQNVTQ 454
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1211 EQLRQEKALLEEIERHGEKVEE-------CQKFAKqyinaIKDYElqliTYKAQLEPvASPAkkPKVQSGSESVIQEYVD 1283
Cdd:PRK10246  455 EQTQRNAALNEMRQRYKEKTQQladvktiCEQEAR-----IKDLE----AQRAQLQA-GQPC--PLCGSTSHPAVEAYQA 522
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1284 LRtryselttltsqyikfISETLRRMEEEERLAEQQRAEERERLAEVEaALEKQRQLAEAHAQAKAQaelEAQELQRRMQ 1363
Cdd:PRK10246  523 LE----------------PGVNQSRLDALEKEVKKLGEEGAALRGQLD-ALTKQLQRDESEAQSLRQ---EEQALTQQWQ 582
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1364 EEVARREEAAVDAQQQKRSIQEELQHLRQ----SSEAEIQAkaqQVEAAERSRMRIEEEIRVVRLQLETTERQrggaege 1439
Cdd:PRK10246  583 AVCASLNITLQPQDDIQPWLDAQEEHERQlrllSQRHELQG---QIAAHNQQIIQYQQQIEQRQQQLLTALAG------- 652
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1440 lQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELA-LRVKAEAEAAREKQRALQALDELR--------LQA 1510
Cdd:PRK10246  653 -YALTLPQEDEEASWLATRQQEAQSWQQRQNELTALQNRIQQLTpLLETLPQSDDLPHSEETVALDNWRqvheqclsLHS 731
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1511 E-EAERRLRQAEAERARQVQVALETAqrsaeveLQSKRasFAEKTAQLERTLQEEhvTVAQLREEAERRAQQQAEAERAR 1589
Cdd:PRK10246  732 QlQTLQQQDVLEAQRLQKAQAQFDTA-------LQASV--FDDQQAFLAALLDEE--TLTQLEQLKQNLENQRQQAQTLV 800
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1590 EEAERELERWQLKANEALRLRLQAEEVAQQksLAQadaekqkeeaerearRRGKAEEQAVRQRELAEQelekQRQLAEGT 1669
Cdd:PRK10246  801 TQTAQALAQHQQHRPDGLDLTVTVEQIQQE--LAQ---------------LAQQLRENTTRQGEIRQQ----LKQDADNR 859

                  ....
gi 254675251 1670 AQQR 1673
Cdd:PRK10246  860 QQQQ 863
PLEC smart00250
Plectin repeat;
3350-3385 4.67e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.16  E-value: 4.67e-04
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 254675251   3350 TLLLEAQAATGFLVDPVRNQRLYVHEAVKAGVVGPE 3385
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
PLEC smart00250
Plectin repeat;
2693-2726 4.76e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.16  E-value: 4.76e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 254675251   2693 LLEAQAASGFLLDPVRNRRLTVNEAVKEGVVGPE 2726
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
DUF4670 pfam15709
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ...
1304-1480 4.89e-04

Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.


Pssm-ID: 434873 [Multi-domain]  Cd Length: 521  Bit Score: 46.10  E-value: 4.89e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1304 ETLRRMEEEERLaEQQRAEERERlaeveaaLEKQRQLAEAHAQAKAQAEleaQELQRRMQEEVARREeaavdaQQQKRSI 1383
Cdd:pfam15709  368 ERAEKMREELEL-EQQRRFEEIR-------LRKQRLEEERQRQEEEERK---QRLQLQAAQERARQQ------QEEFRRK 430
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1384 QEELQHLRQSSEAEiqakaqqvEAAERSRMRIEEEIRVVrlqlETTERQRGGAEGELQALRARAEEAEAQKRQAQEEaer 1463
Cdd:pfam15709  431 LQELQRKKQQEEAE--------RAEAEKQRQKELEMQLA----EEQKRLMEMAEEERLEYQRQKQEAEEKARLEAEE--- 495
                          170
                   ....*....|....*..
gi 254675251  1464 lRRQVQDESQRKRQAEA 1480
Cdd:pfam15709  496 -RRQKEEEAARLALEEA 511
GumC COG3206
Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell wall/membrane ...
1410-1705 4.94e-04

Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225747 [Multi-domain]  Cd Length: 458  Bit Score: 45.90  E-value: 4.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1410 RSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRA--RAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVK 1487
Cdd:COG3206   144 LESLKVLRAGRSRVIELSYTSNDPKLAAKLANALAQayLADQLEAQLEAFRRASDSLDERLEELRARLQEAEAQVEDFRA 223
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1488 AEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVElqskRASFAEKTAQlerTLQEEHVT 1567
Cdd:COG3206   224 QHGLTDAARGQLLSEQQLSALNTQLQSARARLAQAEARLASLLQLLPLGREAAAL----REVLESPTIQ---DLRQQYAQ 296
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1568 VAQLReeaerraqqqaeaerareeaerelerwqlkANEALRLRLQAEEVAQQKSLAQADaEKQKEEAEREARRRGKAEEQ 1647
Cdd:COG3206   297 VRQQI------------------------------ADLSTELGAKHPQLVALEAQLAEL-RQQIAAELRQILASLPNELA 345
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251 1648 AVRQRelaEQELEKQRQLAEGTAQQRLAAEQELIRLraeTEQGEQQRQLLEEELARLQ 1705
Cdd:COG3206   346 LLEQQ---EAALEKELAQLKGRLSKLPKLQVQLREL---EREAEAARSLYETLLQRYQ 397
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
2213-2330 5.03e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 45.26  E-value: 5.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2213 EAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEaarlRQLAEEDLAQQRALAE--KMLKEKMQavQEATRL 2290
Cdd:cd16269   180 EAEAEAILQADQALTEKEKEIEAERAKAEAAEQERKLLEEQQ----RELEQKLEDQERSYEEhlRQLKEKME--EERENL 253
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 254675251 2291 KAEAELLQQQKElaQEQARRLQEDKEQMAQQLVEETQGFQ 2330
Cdd:cd16269   254 LKEQERALESKL--KEQEALLEEGFKEQAELLQEEIRSLK 291
PTZ00491 PTZ00491
major vault protein; Provisional
1643-1786 5.10e-04

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 46.55  E-value: 5.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1643 KAEEQAVRQR-ELAEQElekqrqlaegtAQQRLaaEQELIRLRAETEqgEQQRQLLEEELARLQHEATAATQKRQELEAE 1721
Cdd:PTZ00491  662 KSQEAAARHQaELLEQE-----------ARGRL--ERQKMHDKAKAE--EQRTKLLELQAESAAVESSGQSRAEALAEAE 726
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251 1722 LAKVRAEMEVLLAS-KARAEE-ESRSTSEKSKQRLEAEAGRFRELAE-EAARLRALAE-EAKRQRQLAE 1786
Cdd:PTZ00491  727 ARLIEAEAEVEQAElRAKALRiEAEAELEKLRKRQELELEYEQAQNElEIAKAKELADiEATKFERIVE 795
PLEC smart00250
Plectin repeat;
2981-3018 5.15e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.16  E-value: 5.15e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 254675251   2981 RQALRGTNVIAGVWLEEAGQKLSIYEALKKDLLQPEVA 3018
Cdd:smart00250    1 QRLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
2279-2493 5.27e-04

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 45.71  E-value: 5.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2279 EKMQAVQEATRLKAEAELLQQQKELaqeQARRLQEDKEQMAQQLVEETQGFQRTlEAERQRQLEMSaeaerlKLRMAEMS 2358
Cdd:COG3064    48 SVIDAVMVDPGAVVQQYGRIQSQQS---SAKKGEQQRKKKEEQVAEELKPKQAA-EQERLKQLEKE------RLKAQEQQ 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2359 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKlKQEAKLLQLKS 2438
Cdd:COG3064   118 KQAEEAEKQAQLEQKQQEEQARKAAAEQKKKAEAAKAKAAAEAAKLKAAAEAKKKAEEAAKAAEEAKA-KAEAAAAKKKA 196
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 254675251 2439 EEMQTVQQEQILQETQALQKSFLSEKDSllqrerfiEQEKAKLEQLFQDEVAKAK 2493
Cdd:COG3064   197 EAEAKAAAEKAKAEAEAKAKAEKKAEAA--------AEEKAAAEKKKAAAKAKAD 243
PLEC smart00250
Plectin repeat;
2654-2690 5.30e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 40.16  E-value: 5.30e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   2654 RYLKGRSSIAGLLLKPTNEKLSVYTALQRQLLSPGTA 2690
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
mukB PRK04863
chromosome partition protein MukB;
2210-2578 5.60e-04

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 46.49  E-value: 5.60e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2210 ARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLS-------VAAQEAARLRQLAEEDLAQQRAL--AEKMLKEK 2280
Cdd:PRK04863  281 RRVHLEEALELRRELYTSRRQLAAEQYRLVEMARELAELNeaesdleQDYQAASDHLNLVQTALRQQEKIerYQADLEEL 360
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2281 MQAVQEATRLKAEAellQQQKELAQEQARRLQEDKEQMAQQLVEETQGF--QRTLEAERQRQLEMSAEAERLklrMAEMS 2358
Cdd:PRK04863  361 EERLEEQNEVVEEA---DEQQEENEARAEAAEEEVDELKSQLADYQQALdvQQTRAIQYQQAVQALERAKQL---CGLPD 434
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2359 RAQARAEEDAQRFRKQAEEIGEKLhrteLATQEKVTLVQTLeiqRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKS 2438
Cdd:PRK04863  435 LTADNAEDWLEEFQAKEQEATEEL----LSLEQKLSVAQAA---HSQFEQAYQLVRKIAGEVSRSEAWDVARELLRRLRE 507
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2439 EEMQTVQQEQILQETQALQKSFLSEKDSllqrERFIEQEKAKLEQLFQDEvakakqlreeqqRQQQQMEQEKQELMASME 2518
Cdd:PRK04863  508 QRHLAEQLQQLRMRLSELEQRLRQQQRA----ERLLAEFCKRLGKNLDDE------------DELEQLQEELEARLESLS 571
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 2519 EARRRQREAEEGVRRKQEelqhleqqrqQQEKLLAEENQR------LRERLQRLEEEHRAALAHSE 2578
Cdd:PRK04863  572 ESVSEARERRMALRQQLE----------QLQARIQRLAARapawlaAQDALARLREQSGEEFEDSQ 627
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
1256-1537 5.61e-04

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 45.79  E-value: 5.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1256 AQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELTtltSQYIKFISETLRRMEEEERLAEQ--QRAEERERL-AEVEA 1332
Cdd:COG4372    93 AQGEKRAAETEREAARSELQKARQEREAVRQELAAAR---QNLAKAQQELARLTKQAQDLQTRlkTLAEQRRQLeAQAQS 169
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1333 ALEKQRQLAEAHAQAKaqaeLEAQELQRRmQEEVARREEAAVDAQQQKRSIQEELQHLrqsseaeiQAKAQQVEAAERSR 1412
Cdd:COG4372   170 LQASQKQLQASATQLK----SQVLDLKLR-SAQIEQEAQNLATRANAAQARTEELARR--------AAAAQQTAQAIQQR 236
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1413 MRieeeirvvrlQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEA-E 1491
Cdd:COG4372   237 DA----------QISQKAQQIAARAEQIRERERQLQRLETAQARLEQEVAQLEAYYQAYVRLRQQAAATQRGQVLAGAaQ 306
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 254675251 1492 AAREKQRALQALDELRLQAEE-AERRLRQAEAERARQVQVALETAQR 1537
Cdd:COG4372   307 RVAQAQAQAQAQAQLLSSANRpAALRLRRSPRRGRRQRPVTRHTTRR 353
PRK12678 PRK12678
transcription termination factor Rho; Provisional
1396-1529 5.72e-04

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 46.05  E-value: 5.72e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1396 AEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRK 1475
Cdd:PRK12678   53 AAIKEARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRE 132
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 254675251 1476 RQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQ 1529
Cdd:PRK12678  133 RGEAARRGAARKAGEGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAE 186
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
2409-2537 5.93e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.97  E-value: 5.93e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2409 DAERLREAIAELEREKEKLKQEAKLLqlkseemqtvqqEQILQETQALQKSFLSEKDSLLQRErfiEQEKAKLEQLFQDE 2488
Cdd:PRK00409  514 DKEKLNELIASLEELERELEQKAEEA------------EALLKEAEKLKEELEEKKEKLQEEE---DKLLEEAEKEAQQA 578
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 254675251 2489 VAKAKQLREEQQRQQQQMEQEKQELMAS--MEEARRRQREAEEGVRRKQEE 2537
Cdd:PRK00409  579 IKEAKKEADEIIKELRQLQKGGYASVKAheLIEARKRLNKANEKKEKKKKK 629
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1757-1936 6.10e-04

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 45.71  E-value: 6.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1757 EAGRFRELAEEAARlrALAEEAKRQRQLAEEDAARQRAEAERV--LTEKLAAISEATRLKTEAE--IALKEKEAENERLR 1832
Cdd:COG3064    63 QYGRIQSQQSSAKK--GEQQRKKKEEQVAEELKPKQAAEQERLkqLEKERLKAQEQQKQAEEAEkqAQLEQKQQEEQARK 140
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1833 RLAE----DEAFQRRRLEEQAALHKADIEERLAQlrKASESELERQKGLVEDTLRQRRQVEEEIMALKVSFEKAAAGKAE 1908
Cdd:COG3064   141 AAAEqkkkAEAAKAKAAAEAAKLKAAAEAKKKAE--EAAKAAEEAKAKAEAAAAKKKAEAEAKAAAEKAKAEAEAKAKAE 218
                         170       180
                  ....*....|....*....|....*...
gi 254675251 1909 LELELGRIRSNAEDTMRSKEQAELEAAR 1936
Cdd:COG3064   219 KKAEAAAEEKAAAEKKKAAAKAKADKAA 246
ERM pfam00769
Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at ...
1753-1898 6.45e-04

Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at their amino terminus. This family represents the rest of these proteins.


Pssm-ID: 425860 [Multi-domain]  Cd Length: 247  Bit Score: 44.55  E-value: 6.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1753 RLEAEagrfRELAEEAARLRALAEEAKRqrqlAEEDAARQRAEAERVLTEKLAAISEATRLKTEAeialKEKEAENERLR 1832
Cdd:pfam00769    1 REEAE----REKQELEERLKQYEEETRK----AQEELEESEETAELLEEKLRVAEEEAELLEQKA----QEAEEEKERLE 68
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251  1833 RLAEDEAFQRRRLEEQAALHKADIeERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALKVS 1898
Cdd:pfam00769   69 ESAEMEAEEKEQLERELREAQEEV-ARLEEESERKEEEAERLQEELEEAREEEEEAKEKLLAASTS 133
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
1192-1439 6.56e-04

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 225177 [Multi-domain]  Cd Length: 548  Bit Score: 45.59  E-value: 6.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1192 KRRQEQIQAVPIancQAAREQLRQEKALLEEIERHGEKVE--ECQKFAKQYINAIKDYELQLI-------TYKAQLEPVA 1262
Cdd:COG2268   213 RRRIAQVLQDAE---IAENEAEKETEIAIAEANRDAKLVEleVEQQPAGKTAEQTREVKIILAeteaevaAWKAETRREA 289
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1263 SPAKKPKVQSGSESVIQEYVDLRTR-YSELTTLTSQYIKFISET-LRRMEEEERLAEQQRAEERERLAEVEAAL------ 1334
Cdd:COG2268   290 EQAEILAEQAIQEEKAQAEQEVQHAkALEAREMRVGLIERQKETeLEPQERSYFINAAQRQAQEEAKAAANIAEaigaqa 369
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1335 ----EKQRQLAEAhAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQ-QKRSIQEELQHLRQSSEAE-----IQAKAQQ 1404
Cdd:COG2268   370 eaavETARETEEA-ERAEQAALVAAAEAAEQEQVEIAVRAEAAKAEAEaQAAEIKAEAEAIREKGKAEaeakrALAEAIQ 448
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 254675251 1405 VEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGE 1439
Cdd:COG2268   449 VLGDAAAAELFKALVQALPEVAEEAAQPMKNIDSE 483
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The ...
1031-1565 6.65e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N-terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 46.12  E-value: 6.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1031 ELELTLGKLEQVRSLSAIYLEKLKTISLVIRSTQGAEEVLKthEEQLKEAQAVPATLQELEATKASLKKLRAQAEAQQPV 1110
Cdd:pfam02463  394 EEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEE--EEESIELKQGKLTEEKEELEKQELKLLKDELELKKSE 471
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1111 FNTLRDELRgaQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQ-LGRQLRYYRESADPLSAWLQ 1189
Cdd:pfam02463  472 DLLKETQLV--KLQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHgRLGDLGVAVENYKVAISTAV 549
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1190 DAKRRQEQIQAVPIANCQAAREQLRQEKALLEEIERHGEKVEecQKFAKQYINAIKDYE-LQLITYKAQLEPVASPAK-- 1266
Cdd:pfam02463  550 IVEVSATADEVEERQKLVRALTELPLGARKLRLLIPKLKLPL--KSIAVLEIDPILNLAqLDKATLEADEDDKRAKVVeg 627
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1267 ------------KPKVQSGSESVIQEYVDLRTRYSELTTLTS---QYIKFISETLRRMEEEERLAE-----------QQR 1320
Cdd:pfam02463  628 ilkdteltklkeSAKAKESGLRKGVSLEEGLAEKSEVKASLSeltKELLEIQELQEKAESELAKEEilrrqleikkkEQR 707
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1321 AEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEIQA 1400
Cdd:pfam02463  708 EKEELKKLKLEAEELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLK 787
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1401 KAQQVEAAERS------RMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQ--AQEEAERLRRQVQDES 1472
Cdd:pfam02463  788 VEEEKEEKLKAqeeelrALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEklAEEELERLEEEITKEE 867
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1473 QRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAE 1552
Cdd:pfam02463  868 LLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKYEEEPEELLLEEADE 947
                          570
                   ....*....|...
gi 254675251  1553 KTAQLERTLQEEH 1565
Cdd:pfam02463  948 KEKEENNKEEEEE 960
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
2132-2451 6.90e-04

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 225177 [Multi-domain]  Cd Length: 548  Bit Score: 45.59  E-value: 6.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2132 MEKHKKFAEQTLRQkaqVEQELTTLRLQLE------------ETDHQKSILDEELQRLKAEVTEAARQrsqVEEELfsvr 2199
Cdd:COG2268   161 NEDRLGFAQVVQEV---VGDDLSKMGLVLDslaindindtskENQDPNNYLDALGRRRIAQVLQDAEI---AENEA---- 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2200 VQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQ---EAARLRQLAEEDLAQQRALAEK- 2275
Cdd:COG2268   231 EKETEIAIAEANRDAKLVELEVEQQPAGKTAEQTREVKIILAETEAEVAAWKAEtrrEAEQAEILAEQAIQEEKAQAEQe 310
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2276 -----MLKEKMQAVQEATRLKaEAELLQQQKEL--------AQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLE 2342
Cdd:COG2268   311 vqhakALEAREMRVGLIERQK-ETELEPQERSYfinaaqrqAQEEAKAAANIAEAIGAQAEAAVETARETEEAERAEQAA 389
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2343 MSAEAErlkLRMAEMSRAQARAEEDAQRFRKQAEEIgeklhRTELATQEKVTLVQtLEIQRQQSdhDAERLREAIAELER 2422
Cdd:COG2268   390 LVAAAE---AAEQEQVEIAVRAEAAKAEAEAQAAEI-----KAEAEAIREKGKAE-AEAKRALA--EAIQVLGDAAAAEL 458
                         330       340
                  ....*....|....*....|....*....
gi 254675251 2423 EKEKLKQEAKLLQLKSEEMQTVQQEQILQ 2451
Cdd:COG2268   459 FKALVQALPEVAEEAAQPMKNIDSEKVRV 487
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
2251-2432 6.95e-04

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 45.32  E-value: 6.95e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2251 AAQEAARLRQLAEEdlaQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKE--LAQEQARRLQEDKEQMAQQLVEETQG 2328
Cdd:COG3064    60 VVQQYGRIQSQQSS---AKKGEQQRKKKEEQVAEELKPKQAAEQERLKQLEKerLKAQEQQKQAEEAEKQAQLEQKQQEE 136
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2329 FQRTLEAERQRQLE-----MSAEAERLKLR--MAEMSRAQARAEEDAQrfrKQAEEIGEKLHRtELATQEKVTLVQTLEI 2401
Cdd:COG3064   137 QARKAAAEQKKKAEaakakAAAEAAKLKAAaeAKKKAEEAAKAAEEAK---AKAEAAAAKKKA-EAEAKAAAEKAKAEAE 212
                         170       180       190
                  ....*....|....*....|....*....|.
gi 254675251 2402 QRQQSDHDAERLREAIAELEREKEKLKQEAK 2432
Cdd:COG3064   213 AKAKAEKKAEAAAEEKAAAEKKKAAAKAKAD 243
PspC_subgroup_1 NF033838
pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, ...
1364-1848 6.98e-04

pneumococcal surface protein PspC, choline-binding form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A. The other form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site.


Pssm-ID: 411407 [Multi-domain]  Cd Length: 684  Bit Score: 45.77  E-value: 6.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1364 EEVARREEAAVDAQQQK--RSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEG-EL 1440
Cdd:NF033838   53 NESQKEHAKEVESHLEKilSEIQKSLDKRKHTQNVALNKKLSDIKTEYLYELNVLKEKSEAELTSKTKKELDAAFEQfKK 132
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1441 QALRARAEEAEAQK------RQAQEEAERLRRQVQDESQRKRQAE-AELALRVKaEAEAAREKQRALQALDELRLQAEEA 1513
Cdd:NF033838  133 DTLEPGKKVAEATKkveeaeKKAKDQKEEDRRNYPTNTYKTLELEiAESDVEVK-KAELELVKEEAKEPRDEEKIKQAKA 211
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1514 ERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKtaqlertlqeehvtvaqlreeaerraqqqaeaerareeae 1593
Cdd:NF033838  212 KVESKKAEATRLEKIKTDREKAEEEAKRRADAKLKEAVEK---------------------------------------- 251
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1594 relerwqlkaNEALRLRLQAEEVAQQKSLAQADAEKQKEEAErearrrgKAEEQAVRQRELAEQELEKQRQLAEgtAQQR 1673
Cdd:NF033838  252 ----------NVATSEQDKPKRRAKRGVLGEPATPDKKENDA-------KSSDSSVGEETLPSPSLKPEKKVAE--AEKK 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1674 LAAEQElirlRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEmevllasKARAEEESRSTSEKSKQR 1753
Cdd:NF033838  313 VEEAKK----KAKDQKEEDRRNYPTNTYKTLELEIAESDVKVKEAELELVKEEAK-------EPRNEEKIKQAKAKVESK 381
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1754 LeAEAGRFrelaeeaarlralaEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAENERLRR 1833
Cdd:NF033838  382 K-AEATRL--------------EKIKTDRKKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPAEQPKAEK 446
                         490
                  ....*....|....*..
gi 254675251 1834 LAEDEAFQ--RRRLEEQ 1848
Cdd:NF033838  447 PADQQAEEdyARRSEEE 463
MukB COG3096
Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 ...
1114-1862 7.09e-04

Chromosome condensin MukBEF, ATPase and DNA-binding subunit MukB [Escherichia coli str. K-12 substr. MG1655 [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 225638 [Multi-domain]  Cd Length: 1480  Bit Score: 46.03  E-value: 7.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1114 LRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAV-----LAQTDVRQREleqlgrQLRYYRESADPLSAwl 1188
Cdd:COG3096   291 FRRELYTSRQQLAAEQYRHVDMSRELAELNGAEGDLEADYQAAsdhlnLVQTALRQQE------KIERYQADLEELTI-- 362
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1189 qdakRRQEQIQAVPIANCQAAREQLRQEKALLE------EIERHGEKVEECQKFAKQYINAIKDYE-LQLITYKAQLEPV 1261
Cdd:COG3096   363 ----RLEEQNEVVEEANERQEENEARAEAAELEvdelksQLADYQQALDVQQTRAIQYQQAIAALErAKELCHLPDLTAD 438
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1262 ASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQYIKF------------------ISETLRRMEEEERLAEQQRAEE 1323
Cdd:COG3096   439 SAEEWLETFQAKEEEATEKLLSLEQKMSMAQAAHSQFEQAyqlvvaiagelarseawdVARELLREGPDQRHLAEQVQPL 518
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1324 RERLAEVEAALEKQRQ----LAEAHAQAKAQAELEAQELQRRMQ----EEVARREEAAVDAQQQKRSIQEELQHLRQSSE 1395
Cdd:COG3096   519 RMRLSELEQRLRQQQSaerlLADFCKRQGKNLDAEELEALHQELealiESLSDSVSNAREQRMALRQEQEQLQSRIQSLM 598
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1396 AE----IQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRggaegelqALRARAEEAEAQKRQAQEEAERLRRQVQDE 1471
Cdd:COG3096   599 QRapvwLAAQNALEQLSEQSGEEFTDSQDVTEYMQQLLERER--------EATVERDELGARKNALDEEIERLSQPGGSE 670
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1472 SQR-KRQAE-------AELALRVKAE--------------------AEAAREKQRAL--------------QALDELRLQ 1509
Cdd:COG3096   671 DQRlNALAErfggvllSEIYDDVTIEdapyfsalygpsrhaivvpdLSQVKEHLEGLtdcpedlyliegdpQSFDDSVFS 750
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1510 AEE---------AERRLRQA-----------------EAERARQVQVALETAQRSAEVE-LQSKRASFAE---------- 1552
Cdd:COG3096   751 VDElekavvvkiADRQWRYSrfpeiplfgraareqrlESLHAERDVLSERHATLSFDVQkTQRLHQAFSRfigshlavaf 830
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1553 -------------KTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQ- 1618
Cdd:COG3096   831 eadpeaeirqlnsRRNELERALSNHENDNQQQRIQFDQAKEGVTALNRLIPQLNLLADESLADRVEEIRERLDEAQEAAr 910
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1619 ------------QKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQR----------------QLAEGTA 1670
Cdd:COG3096   911 fiqqhgntlsklEPIASVLQSDPEQFEQLKEDYAQAQQMQRQARQQAFALTEVVQRRahfsysdsaemlsensDLNEKLR 990
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1671 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAK--VRAEMEVLLASKARAEE--ESRST 1746
Cdd:COG3096   991 QRLEQAEAERTRAREQLRQHQAQLSQYNQVLASLKSSYDTKKELLNELQQELQDigVRADSGAEERARIRRDElhAQLST 1070
                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1747 SEKSKQRLEaEAGRFRELAEEA--ARLRALAEEAKRQRQLAEEDAA---------RQRAEAERVLTEKLAAIS--EATRL 1813
Cdd:COG3096  1071 NRSRRNQLE-KQLTFCEAEMDNltRKLRKLERDYFEMREQVVTAKAgwcavmrmvKDNGVERRLHRRELAYLSadELRSM 1149
                         890       900       910       920       930
                  ....*....|....*....|....*....|....*....|....*....|..
gi 254675251 1814 KTEAEIALKEKEAENERLR---RLAEDEAFQRRRLEEQAALHKaDIEERLAQ 1862
Cdd:COG3096  1150 SDKALGALRLAVADNEHLRdvlRLSEDPKRPERKIQFFIAVYQ-HLRERIRQ 1200
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
1228-1511 7.10e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 45.82  E-value: 7.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1228 EKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAKKPKVQSGSESVIQEYVDLRTRYSELTTLTSQyikfisETLR 1307
Cdd:PRK10929   58 EERKGSLERAKQYQQVIDNFPKLSAELRQQLNNERDEPRSVPPNMSTDALEQEILQVSSQLLEKSRQAQQ------EQDR 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1308 RMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAeleaqelqrrMQEEVARReEAAVDaqqqkrsiQE 1385
Cdd:PRK10929  132 AREISDSLSQlpQQQTEARRQLNEIERRLQTLGTPNTPLAQAQLTA----------LQAESAAL-KALVD--------EL 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1386 ELQHLRQSSEAEIqakaqqveaaerSRMRIeeeirvvrlqlETTERQRGGAEGELQALRAR--------AEEAEAQKRQA 1457
Cdd:PRK10929  193 ELAQLSANNRQEL------------ARLRS-----------ELAKKRSQQLDAYLQALRNQlnsqrqreAERALESTELL 249
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675251 1458 QEEAERLRRQVQDESQRKRQAEAEL---ALRVKAEA----EAAREKQRALQALDELRLQAE 1511
Cdd:PRK10929  250 AEQSGDLPKSIVAQFKINRELSQALnqqAQRMDLIAsqqrQAASQTLQVRQALNTLREQSQ 310
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
2172-2377 7.13e-04

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 45.32  E-value: 7.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2172 EELQRLKAEVTEAARQRsqvEEELFSVRVQMEELGKLKARIEAENRAL-ILRDKDNTQRFLEEEAEKMKQVAEEAARlSV 2250
Cdd:COG3064    62 QQYGRIQSQQSSAKKGE---QQRKKKEEQVAEELKPKQAAEQERLKQLeKERLKAQEQQKQAEEAEKQAQLEQKQQE-EQ 137
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2251 AAQEAARLRQLAEEDLAQQRALAEKmLKEKMQAvqeatrlKAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQ 2330
Cdd:COG3064   138 ARKAAAEQKKKAEAAKAKAAAEAAK-LKAAAEA-------KKKAEEAAKAAEEAKAKAEAAAAKKKAEAEAKAAAEKAKA 209
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 254675251 2331 rtlEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEE 2377
Cdd:COG3064   210 ---EAEAKAKAEKKAEAAAEEKAAAEKKKAAAKAKADKAAAAAKAAE 253
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
1448-1527 7.52e-04

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 45.71  E-value: 7.52e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1448 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELAL----RVKAE--AEAAREKQRALQA-LDELRLQAEEAERRLRQA 1520
Cdd:PRK11448  138 EDPENLLHALQQEVLTLKQQLELQAREKAQSQALAEAqqqeLVALEglAAELEEKQQELEAqLEQLQEKAAETSQERKQK 217

                  ....*..
gi 254675251 1521 EAERARQ 1527
Cdd:PRK11448  218 RKEITDQ 224
GumC COG3206
Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell wall/membrane ...
1259-1530 7.78e-04

Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225747 [Multi-domain]  Cd Length: 458  Bit Score: 45.51  E-value: 7.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1259 EPVASPAKKPKVQSGSESVIQEYvdlrTRYSELTTLTSQYIKFISETLRRMEEEERLAEQQRA---------EERERLAE 1329
Cdd:COG3206   138 YRLDDLLESLKVLRAGRSRVIEL----SYTSNDPKLAAKLANALAQAYLADQLEAQLEAFRRAsdslderleELRARLQE 213
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1330 VEAALEKQRQLAEAHAQAKAQAELEAQ--ELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAE---IQAKAQQ 1404
Cdd:COG3206   214 AEAQVEDFRAQHGLTDAARGQLLSEQQlsALNTQLQSARARLAQAEARLASLLQLLPLGREAAALREVLEsptIQDLRQQ 293
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1405 VEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEaeaqkrQAQEEAERLRRQVQDESQRKRQAEAELAL 1484
Cdd:COG3206   294 YAQVRQQIADLSTELGAKHPQLVALEAQLAELRQQIAAELRQILA------SLPNELALLEQQEAALEKELAQLKGRLSK 367
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*.
gi 254675251 1485 RVKAEAEaAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQV 1530
Cdd:COG3206   368 LPKLQVQ-LRELEREAEAARSLYETLLQRYQELSIQEASPIGNARV 412
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
1757-1866 7.97e-04

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 45.71  E-value: 7.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1757 EAGRFRELAEEAARLRALAEEAKRQRQLAEE--------DAARQRAEAERVLTEKLAAISEATRLKTEAEIA-LKEKEAE 1827
Cdd:PRK11448  130 KPGPFVPPEDPENLLHALQQEVLTLKQQLELqarekaqsQALAEAQQQELVALEGLAAELEEKQQELEAQLEqLQEKAAE 209
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 254675251 1828 NERLRRLaedeafQRRRLEEQAAlHKADIEERL------AQLRKA 1866
Cdd:PRK11448  210 TSQERKQ------KRKEITDQAA-KRLELSEEEtrilidQQLRKA 247
PRK06991 PRK06991
electron transport complex subunit RsxB;
1317-1420 7.98e-04

electron transport complex subunit RsxB;


Pssm-ID: 235903 [Multi-domain]  Cd Length: 270  Bit Score: 44.79  E-value: 7.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1317 EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAqelqrRMQEEVARREEAAVDAQQQKRS-IQEELQHLRQSSE 1395
Cdd:PRK06991  149 QAQADAARARHDARQARLRREREAAEARAAARAAASAAA-----AAAEASAAAAPAADDAEAKKRAiIAAALERARKKKE 223
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 254675251 1396 ----------------AEIQAkaqQVEAAERSRMRIEEEIR 1420
Cdd:PRK06991  224 elaaqgagpkntegvsAAVQA---QIDAAEARRKRLAEQRD 261
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
1476-1818 8.01e-04

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 45.71  E-value: 8.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1476 RQAEAELALRVKAEAEAAREKQR--ALQAldelRLQAEEAERRLRQAEAERARQVQValETAQRSAEVELQSKRASFAEK 1553
Cdd:PRK05035  432 RQAKAEIRAIEQEKKKAEEAKARfeARQA----RLEREKAAREARHKKAAEARAAKD--KDAVAAALARVKAKKAAATQP 505
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1554 TAQLERTLQEEHVTVAQLREEaerraqqqaeaerareeaerelerwqlkanealrlRLQAEEVAQQKSLAQADAEKQKEE 1633
Cdd:PRK05035  506 IVIKAGARPDNSAVIAAREAR-----------------------------------KAQARARQAEKQAAAAADPKKAAV 550
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1634 AEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAqqrlaaeqelirlRAETEQGEQQrqlleeelarlqHEATAATQ 1713
Cdd:PRK05035  551 AAAIARAKAKKAAQQAANAEAEEEVDPKKAAVAAAIA-------------RAKAKKAAQQ------------AASAEPEE 605
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1714 KRQELEAELAKVRAEMEVLLASKARAEEESRSTSEkskqrleaeagrfrelaeEAARLRALAEE---AKRQRQLAEEDAA 1790
Cdd:PRK05035  606 QVAEVDPKKAAVAAAIARAKAKKAEQQANAEPEEP------------------VDPRKAAVAAAiarAKARKAAQQQANA 667
                         330       340
                  ....*....|....*....|....*...
gi 254675251 1791 RQRAEAERVLTEKLAAISEATRLKTEAE 1818
Cdd:PRK05035  668 EPEEAEDPKKAAVAAAIARAKAKKAAQQ 695
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
1672-1827 8.18e-04

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 45.59  E-value: 8.18e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1672 QRLAAEQELIRlRAETEQGEQQRQLlEEELARLQHEATAATQKRQELEAELAkvraEMEVLLASKARAEEESRSTSEKSK 1751
Cdd:PRK00409  495 KRLGLPENIIE-EAKKLIGEDKEKL-NELIASLEELERELEQKAEEAEALLK----EAEKLKEELEEKKEKLQEEEDKLL 568
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 1752 QRLEAEAgrfrelaeEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEAEIALKEKEAE 1827
Cdd:PRK00409  569 EEAEKEA--------QQAIKEAKKEADEIIKELRQLQKGGYASVKAHELIEARKRLNKANEKKEKKKKKQKEKQEE 636
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
1358-1991 8.29e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 45.48  E-value: 8.29e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1358 LQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAE 1437
Cdd:pfam05483   79 LYSKLYKEAEKIKKWKVSIEAELKQKENKLQENRKIIEAQRKAIQELQFENEKVSLKLEEEIQENKDLIKENNATRHLCN 158
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1438 gELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAElaLRVKAEaeaarekqralQALDELRLQAEEAERRL 1517
Cdd:pfam05483  159 -LLKETCARSAEKTKKYEYEREETRQVYMDLNNNIEKMILAFEE--LRVQAE-----------NARLEMHFKLKEDHEKI 224
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1518 RQAEAERARQV-----QVALETAQrSAEVELQSKRASFaektaqlerTLQEEHVTVAQLREEAERRAQQQAEAERAREEA 1592
Cdd:pfam05483  225 QHLEEEYKKEIndkekQVSLLLIQ-ITEKENKMKDLTF---------LLEESRDKANQLEEKTKLQDENLKELIEKKDHL 294
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1593 ERELERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQlaegTAQQ 1672
Cdd:pfam05483  295 TKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEAQMEELNKAKAAHSFVVTEFEATTCSLEELLR----TEQQ 370
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1673 RLaaeqelirlraetEQGEQQRQLLEEELARLQHEATAATQ----KRQELEaELAKVRAEMEVLLASKARAEEESRSTSE 1748
Cdd:pfam05483  371 RL-------------EKNEDQLKIITMELQKKSSELEEMTKfknnKEVELE-ELKKILAEDEKLLDEKKQFEKIAEELKG 436
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1749 KSKQRLEAEAGRFRELAEEAARLRALaeEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLkteaeialkekeaEN 1828
Cdd:pfam05483  437 KEQELIFLLQAREKEIHDLEIQLTAI--KTSEEHYLKEVEDLKTELEKEKLKNIELTAHCDKLLL-------------EN 501
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1829 ERLRRLAEDEAFQRRRLEEQAALHKADIEERLAQLRKASESELERQKGL--VEDTLRQRR--------QVEEEIMALKVS 1898
Cdd:pfam05483  502 KELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELesVREEFIQKGdevkckldKSEENARSIEYE 581
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1899 FEKAAAGKAELELELGRIRSNAEDTMRSKEQAELE--------AARQRQLAAEEEQRRREAEERVQRSLAAEE------E 1964
Cdd:pfam05483  582 VLKKEKQMKILENKCNNLKKQIENKNKNIEELHQEnkalkkkgSAENKQLNAYEIKVNKLELELASAKQKFEEiidnyqK 661
                          650       660       670
                   ....*....|....*....|....*....|.
gi 254675251  1965 AARQRKVA----LEEVERLKAKVEEARRLRE 1991
Cdd:pfam05483  662 EIEDKKISeeklLEEVEKAKAIADEAVKLQK 692
Filament pfam00038
Intermediate filament protein;
1307-1563 8.37e-04

Intermediate filament protein;


Pssm-ID: 425436 [Multi-domain]  Cd Length: 313  Bit Score: 44.91  E-value: 8.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1307 RRMEEEERLAEQQRAEERERLAEV-EAALEKQRQLAEAHAQAKAQAELEaqelqrrmqeevarREEAAVDAQQQKRSIQE 1385
Cdd:pfam00038   28 KDLETKISELRQKKGAEPSRLYSLyEREIRELRRQLDTLTVERARLQLE--------------LDNLRLAAEDFRQKYED 93
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1386 ELQhLRQSSEAEIQAKAQQVEAAERSR----MRI--------------EEEIRVVRLQLETTERQ---RGGAEGEL-QAL 1443
Cdd:pfam00038   94 ELN-LRQSAEADIVGLRKDLDEATLARvdleMKIeslkeelaflkknhEEEVRELQSQVSDTQVNvemDAARKLDLtSAL 172
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1444 RARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQA-LDELRLQAEEAERRLRQAEA 1522
Cdd:pfam00038  173 AEIRAQYEEIAEKNREEAEEWYQSKLEELQQAAARNGDALRSAKEEITELRRQIQSLEIeLQSLKKQKASLERQLAETEE 252
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|.
gi 254675251  1523 ERARQvqvaLETAQRSaeveLQSKRASFAEKTAQLERTLQE 1563
Cdd:pfam00038  253 RYELQ----LADYQEL----ISELEAELQQIRQEMARQLRE 285
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
1315-1753 8.70e-04

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 227606 [Multi-domain]  Cd Length: 833  Bit Score: 45.79  E-value: 8.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1315 LAEQQRAEERERLAEVEAALEKQ----RQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHL 1390
Cdd:COG5281   212 ITQHQAAEVLAQLVAAGVATAEQlgdvAQAAARFASASGESIDKTIKAFSKLTDDPVNGAKALNRQFHYLTAAQLEQIAA 291
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1391 RQSSEAEIQAKAQQVEAA---ERSRMRIEEEIRVV-RLQLETTERQRGGAEGELQALRARAEEA-EAQKRQAQEEAERLR 1465
Cdd:COG5281   292 LQRAGDTAAAAAAAAEAAaamDDRTARVKENMGTLeTAWDALADAAKKMWDAVLGIGREDKQAAlLAAKLAAEKLARVTA 371
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1466 RQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQvqvaletAQRSAEVELQS 1545
Cdd:COG5281   372 QGALNARLKLAQDDLTQAELNYAAADQAANQEGALNAREDEAEVLSTQEERRDILKNLLADA-------EKRTARQEELN 444
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1546 KRASFAEKtaqlertlqeehvtvAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQAEEVAQQKSLAQA 1625
Cdd:COG5281   445 KALAKAKI---------------LQADKAAKAYQEDILQREAQSRGKTAAAERSQEQMTAALKALLAFQQQIADLSGAKE 509
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1626 DAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQ--------RQLAEGTAQQRLAAEQeliRLRAETEQGEQQRQLL 1697
Cdd:COG5281   510 KASDQKSLLWKAEEQYALLKEEAKQRQLQEQKALLEHkketleytSQLAELLDQQADRFEL---SAQAAGSQKERGSDLY 586
                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251 1698 EEELARL-QHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQR 1753
Cdd:COG5281   587 REALAQNaAALNKALNELAAYWSALDLLQGDWKAGALSALANYRDSATDVASQAAQL 643
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
1317-1418 8.94e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 44.49  E-value: 8.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1317 EQQRAEERERLAEVEAALEKQRQLAEAHAQAkaqaelEAQELQRRMQEEVARREEaaVDAQQQKRSIQEELQHLRQSSEA 1396
Cdd:cd16269   177 QSKEAEAEAILQADQALTEKEKEIEAERAKA------EAAEQERKLLEEQQRELE--QKLEDQERSYEEHLRQLKEKMEE 248
                          90       100
                  ....*....|....*....|..
gi 254675251 1397 EIQAKAQQVEAAERSRMRIEEE 1418
Cdd:cd16269   249 ERENLLKEQERALESKLKEQEA 270
PTZ00491 PTZ00491
major vault protein; Provisional
1377-1546 8.99e-04

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 45.39  E-value: 8.99e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1377 QQQKRSIQEELQHLRQSSEAEIQAKAQQVE-----AAERSRM--RIE-EEIRVVRLQLETTerqrgGAEGELQAlRARAE 1448
Cdd:PTZ00491  647 DSLQKSVQLAIEITTKSQEAAARHQAELLEqeargRLERQKMhdKAKaEEQRTKLLELQAE-----SAAVESSG-QSRAE 720
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1449 -EAEAQKRQAQEEAErlrrqVQDESQRKRqaeaelALRVKAEAEAAREKQRALQALDELRLQAE---EAERRLRQAEAER 1524
Cdd:PTZ00491  721 aLAEAEARLIEAEAE-----VEQAELRAK------ALRIEAEAELEKLRKRQELELEYEQAQNEleiAKAKELADIEATK 789
                         170       180
                  ....*....|....*....|....*.
gi 254675251 1525 ARQVQVAL--ET--AQRSAEVELQSK 1546
Cdd:PTZ00491  790 FERIVEALgrETliAIARAGPELQAK 815
DUF812 pfam05667
Protein of unknown function (DUF812); This family consists of several eukaryotic proteins of ...
1302-1559 9.28e-04

Protein of unknown function (DUF812); This family consists of several eukaryotic proteins of unknown function.


Pssm-ID: 428574 [Multi-domain]  Cd Length: 601  Bit Score: 45.39  E-value: 9.28e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1302 ISETLR----RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQ 1377
Cdd:pfam05667  252 IAEQLRsaalASTEATSGASRSKQDLAELLSSFGGSSTTDTNLTKGSRFTHTEKLQFTNEEAPAATSSPPTKAETEEELQ 331
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1378 QQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRggaegelqALRARA-EEAEaqkrQ 1456
Cdd:pfam05667  332 QQREEELEELQEQLEELESSIEELEKEIKKLESSIKQVEEELEELKEQNEELEKQY--------KVKKKTlDLLP----D 399
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1457 AQEEAERLRRQVQDESQRKrqaeAELAlrvkAEAEAAR----EKQRALQalDELRLQAEEAERRLRQAEAERARQVQVAl 1532
Cdd:pfam05667  400 AEENIAKLQALVEASAQRL----VELA----GQWEKHRvpliEEYRALK--EAKSNKESESQRKLEEIKELREKIKEVA- 468
                          250       260
                   ....*....|....*....|....*..
gi 254675251  1533 etaqrsaeVELQSKRASFAEKTAQLER 1559
Cdd:pfam05667  469 --------EEARSKEELYKQLVAEYER 487
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
2244-2469 9.62e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 45.43  E-value: 9.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2244 EAARLsvAAQEAARLRQLAEE--DLAQQRALAEKMLKE---KMQAVQEATRLKAEAELLQQQKELA-------------- 2304
Cdd:PRK10929  120 EKSRQ--AQQEQDRAREISDSlsQLPQQQTEARRQLNEierRLQTLGTPNTPLAQAQLTALQAESAalkalvdelelaql 197
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2305 -----QEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAE-AERLKLRMAEMSRAQARA----EEDAQRFRKQ 2374
Cdd:PRK10929  198 sannrQELARLRSELAKKRSQQLDAYLQALRNQLNSQRQREAERALEsTELLAEQSGDLPKSIVAQfkinRELSQALNQQ 277
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2375 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQ------SDHDAERLREAIA---------ELERE-----------KEKLK 2428
Cdd:PRK10929  278 AQRMDLIASQQRQAASQTLQVRQALNTLREQsqwlgvSNALGEALRAQVArlpempkpqQLDTEmaqlrvqrlryEDLLN 357
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 254675251 2429 QEAKLLQLKSEEMQ--TVQQEQILQETQALQKSFLSekdSLLQ 2469
Cdd:PRK10929  358 KQPQLRQIRQADGQplTAEQNRILDAQLRTQRELLN---SLLS 397
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
2310-2589 9.63e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.43  E-value: 9.63e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2310 RLQEDKEQMAQQLVEETQGFQRT--LEAERQRQLE-MSAEAERlklrmAEMSRAQARAEEDAQR--FRKQAEEIGEKLHR 2384
Cdd:TIGR02168  169 KYKERRKETERKLERTRENLDRLedILNELERQLKsLERQAEK-----AERYKELKAELRELELalLVLRLEELREELEE 243
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2385 TELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQ-----LKSEEMQTVQQEQILQETQALQKS 2459
Cdd:TIGR02168  244 LQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKELYALAneisrLEQQKQILRERLANLERQLEELEA 323
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2460 FLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRKQEELQ 2539
Cdd:TIGR02168  324 QLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIE 403
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|
gi 254675251  2540 HLEQQRQQQEKLLAEENQRLRERLQRLeEEHRAALAHSEIATTQAASTKA 2589
Cdd:TIGR02168  404 RLEARLERLEDRRERLQQEIEELLKKL-EEAELKELQAELEELEEELEEL 452
DUF4175 pfam13779
Domain of unknown function (DUF4175);
1302-1540 9.81e-04

Domain of unknown function (DUF4175);


Pssm-ID: 433472 [Multi-domain]  Cd Length: 817  Bit Score: 45.34  E-value: 9.81e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1302 ISETLRRMEE-EERLAEQ-----QRAEERERLAEVEAALEK-QRQLAE---------AHAQAKAQAELEAQELQRRMQ-- 1363
Cdd:pfam13779  466 LSDAERRLRAaQERLSEAlergaSDEEIARLMQELRAALDDyMQALAEqaqrnpqaqQARPGDNAQQMTQQDLQRMMDri 545
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1364 EEVAR--REEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEirvvRLQLET---TERQRGGAEG 1438
Cdd:pfam13779  546 EELARsgRRAEAQQMLSQLQQMMENLQAAQPQQGQQQAQGEMQQAMDELGDLLREQQ----QLLDETfrqLQEQRRGQQG 621
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1439 ELQalraraeEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAE---LALRVKAEAEAAREKQRAL--------QALDELR 1507
Cdd:pfam13779  622 QQG-------GGQPGQPQQGQQGQQLGGQQGQGGPGEGQGGPDgggLAQRQQALRRRLEELQDELkgqgqepgDALGDAG 694
                          250       260       270
                   ....*....|....*....|....*....|....
gi 254675251  1508 LQAEEAERRLRQAEAERARQVQV-ALETAQRSAE 1540
Cdd:pfam13779  695 RAMGDAEDALGQGDGAEAVDAQGrALEALRQGAQ 728
PLEC smart00250
Plectin repeat;
3021-3054 9.85e-04

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 39.39  E-value: 9.85e-04
                            10        20        30
                    ....*....|....*....|....*....|....
gi 254675251   3021 LLEAQAGTGHIIDPATSARLTVDEAVRAGLVGPE 3054
Cdd:smart00250    3 LLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPE 36
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1509-1832 1.00e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 429718 [Multi-domain]  Cd Length: 488  Bit Score: 45.26  E-value: 1.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1509 QAEEAERRLRQAEAERARQVQvALETAQRSAEVELQ---SKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEA 1585
Cdd:pfam07888   28 RAELLQNRLEECLQERAELLQ-AQEAANRQREKEKErykRDREQWERQRRELESRVAELKEELRQSREKVEELEEKYKEL 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1586 ERAREEAERELERwQLKANEALRLRLQAEE-----VAQQKSLAQADAEKQKEEAerearrrgkaeEQAVRQRELAEQELE 1660
Cdd:pfam07888  107 SRSGEELAEEKDA-LLAQRAESEARIRELEediktLTQRVLERETELERMKERV-----------KKAGAQRKEEEAERK 174
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1661 KQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAE 1740
Cdd:pfam07888  175 QLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQVLQLQDTITTLTQKLTTAHRKEAENEALLEELRSLQERLNASERKVE 254
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1741 EESRSTSEKSKQR--LEAEAGRFR-ELAEEAARLR--ALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAisEATRLkt 1815
Cdd:pfam07888  255 GLGEELSSMAAQRdrTQAELHQARlQAAQLTLQLAdaSLALREGRARWAQERETLQQSAEADKDRIEKLSA--ELQRL-- 330
                          330
                   ....*....|....*..
gi 254675251  1816 eaEIALKEKEAENERLR 1832
Cdd:pfam07888  331 --EERLQEERMEREKLE 345
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
2293-2534 1.00e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 227278 [Multi-domain]  Cd Length: 420  Bit Score: 45.10  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2293 EAELLQQQKELAQ-EQARRLQEDKEQMAQQLVEETQGFQRTLEAERqRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRf 2371
Cdd:COG4942    37 DKQLKQIQKEIAAlEKKIREQQDQRAKLEKQLKSLETEIASLEAQL-IETADDLKKLRKQIADLNARLNALEVQEREQR- 114
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2372 RKQAEEI------GEKLHRTELATQEKVTLVQTLEIQRQqsdHDAERLREAIAELEREKEKLKQ-----EAKLLQLKSEE 2440
Cdd:COG4942   115 RRLAEQLaalqrsGRNPPPALLVSPEDAQRSVRLAIYYG---ALNPARAERIDALKATLKQLAAvraeiAAEQAELTTLL 191
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2441 MQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEA 2520
Cdd:COG4942   192 SEQRAQQAKLAQLLEERKKTLAQLNSELSADQKKLEELRANESRLKNEIASAEAAAAKAREAAAAAEAAAARARAAEAKR 271
                         250
                  ....*....|....
gi 254675251 2521 RRRQREAEEGVRRK 2534
Cdd:COG4942   272 TGETYKPTAPEKML 285
YhaN COG4717
Uncharacterized protein YhaN, contains AAA domain [Function unknown];
1613-2025 1.04e-03

Uncharacterized protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 227061 [Multi-domain]  Cd Length: 984  Bit Score: 45.22  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1613 AEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAvrqrELAEQELEKQRQLAEGTAQQRLAaeqELIRLRAETEQGEQ 1692
Cdd:COG4717   184 NQLLEKLKQERNEIDEAEKEYATYHKLLESRRAEHA----RLAELRSELRADRDHIRALRDAV---ELWPRLQEWKQLEQ 256
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1693 QRQLLEEELARLQ----HEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEA 1768
Cdd:COG4717   257 ELTRRREELATFPrdgvLRLEKREAHLQKTEAEIDALLVRLAELKDLASQLIPAKEAVLQALVRLHQQLSEIKASAFELT 336
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1769 ARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEATRLKTEA--------EIALKEKEAENERLRRLAEDEaf 1840
Cdd:COG4717   337 ETLAGIEADLRDKEEAAGNGFEAERVHDLRSLECMLRYQSSQRELKQTEaayckrldEKRLFEDEAEEEARQRLADDE-- 414
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1841 QRRRLEEQAALHKA-------DIEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEimalkvsfEKAAAGKAELELEL 1913
Cdd:COG4717   415 EEVRAGDEAREEKIaansqviDKEEVCNLYDRRDTAWQKQRFLREKQTAFERQKTEHT--------KIIALRLAGMLLVA 486
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1914 GRIRSNAEDTMRSKEqaelEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAarqRKVALEEVERLKAKVEEARRLRERA 1993
Cdd:COG4717   487 LSRLLTSLIFQIIFA----VAQIVFLSAEIKSSSRAVREEKAAVTDIPEELA---RLLITDELPELAVDLLVQSRIRQHW 559
                         410       420       430
                  ....*....|....*....|....*....|....
gi 254675251 1994 EQESAR--QLQLAQEAAQKRLQAEEKAHAFVVQQ 2025
Cdd:COG4717   560 QQLRKAldQLEAAYEALEGRFAAAEAAMAEWQSE 593
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
1060-1745 1.07e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 45.60  E-value: 1.07e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1060 IRSTQGAEEVLKTHEEQLKEAQAVPATLQE-LEATKASLKKLRAQAEAQqpvFNTLRDELRGAQEVG-ERLQQRHGERDV 1137
Cdd:pfam12128  250 FNTLESAELRLSHLHFGYKSDETLIASRQEeRQETSAELNQLLRTLDDQ---WKEKRDELNGELSAAdAAVAKDRSELEA 326
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1138 EVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQLRYYRESADPLSAWLQDAKRRQEQIQAVPIANCQAAREQLRQEK 1217
Cdd:pfam12128  327 LEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQDVTAKYNRRRSKIKEQNNRDIAGIKDKLAKIREAR 406
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1218 AL-LEEIERHGEKVE-ECQKFAKQYINAIKDYELQLITYKAQL-----EPVASPAKKPKVQSGSESVIQEYVDLRTRYSE 1290
Cdd:pfam12128  407 DRqLAVAEDDLQALEsELREQLEAGKLEFNEEEYRLKSRLGELklrlnQATATPELLLQLENFDERIERAREEQEAANAE 486
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1291 LTTLTSQYIKFIS---ETLRRMEEEERLAEQQRaeerERLAEVEAALEKQRqlAEAHAQAKAQAELEAQELQRRMQEEVA 1367
Cdd:pfam12128  487 VERLQSELRQARKrrdQASEALRQASRRLEERQ----SALDELELQLFPQA--GTLLHFLRKEAPDWEQSIGKVISPELL 560
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1368 RREEaaVDAQQQKRSIQEELQ------HLRQ-------SSEAEIQAKAQQVE----AAERSRMRIEEEIRVVRLQLETTE 1430
Cdd:pfam12128  561 HRTD--LDPEVWDGSVGGELNlygvklDLKRidvpewaASEEELRERLDKAEealqSAREKQAAAEEQLVQANGELEKAS 638
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1431 RQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRalQALDELRLQA 1510
Cdd:pfam12128  639 REETFARTALKNARLDLRRLFDEKQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQK--EQKREARTEK 716
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1511 EEAERRLRQAEAERARQVQVALETAQRSAEVELQS----------KRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQ 1580
Cdd:pfam12128  717 QAYWQVVEGALDAQLALLKAAIAARRSGAKAELKAletwykrdlaSLGVDPDVIAKLKREIRTLERKIERIAVRRQEVLR 796
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1581 QQAEAErareeaerelERWQLkanEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELE 1660
Cdd:pfam12128  797 YFDWYQ----------ETWLQ---RRPRLATQLSNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSENLR 863
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1661 KQRQLAEGTAQQRLAAEQElirlRAETEQGEQQRQlLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAE 1740
Cdd:pfam12128  864 GLRCEMSKLATLKEDANSE----QAQGSIGERLAQ-LEDLKLKRDYLSESVKKYVEHFKNVIADHSGSGLAETWESLREE 938

                   ....*
gi 254675251  1741 EESRS 1745
Cdd:pfam12128  939 DHYQN 943
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
1310-1493 1.14e-03

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 44.94  E-value: 1.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1310 EEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQH 1389
Cdd:PRK05035  522 AREARKAQARARQAEKQAAAAADPKKAAVAAAIARAKAKKAAQQAANAEAEEEVDPKKAAVAAAIARAKAKKAAQQAASA 601
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1390 LRQSSEAEIQAKAQQVEAA-ERSRMRIEEEIRVVRLQLETTERQRggaegELQALRARAEEAEAQKRQAQEEAErlrrqv 1468
Cdd:PRK05035  602 EPEEQVAEVDPKKAAVAAAiARAKAKKAEQQANAEPEEPVDPRKA-----AVAAAIARAKARKAAQQQANAEPE------ 670
                         170       180
                  ....*....|....*....|....*
gi 254675251 1469 QDESQRKRQAEAELAlRVKAEAEAA 1493
Cdd:PRK05035  671 EAEDPKKAAVAAAIA-RAKAKKAAQ 694
PspA COG1842
Phage shock protein A [Transcription, Signal transduction mechanisms];
1300-1526 1.22e-03

Phage shock protein A [Transcription, Signal transduction mechanisms];


Pssm-ID: 224755 [Multi-domain]  Cd Length: 225  Bit Score: 43.46  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1300 KFISETLRRMEEEERLAEQQRAEERERLAEVEaalekqRQLAEAHAQAKaQAELEAQELQRRMqEEVARREEAAVDAQQQ 1379
Cdd:COG1842    13 ANINELLDKAEDPEKMLEQAIRDMESELAKAR------QALAQAIARQK-QLERKLEEAQARA-EKLEEKAELALQAGNE 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1380 KrsiqeelqhLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKR---- 1455
Cdd:COG1842    85 D---------LAREALEEKQSLEDLAKALEAELQQAEEQVEKLKKQLAALEQKIAELRAKKEALKARKAAAKAQEKvnrs 155
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251 1456 -------QAQEEAERLRRQVQDesqrkRQAEAELAlrvkaeAEAAREKQRALQALDElrlQAEEAERRLRQAEAERAR 1526
Cdd:COG1842   156 lgggsssSAMAAFERMEEKIEE-----REARAEAA------AELAEGSGDDLDKEFA---QAGAQSAVDSRLAALKAR 219
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
1308-1495 1.27e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 44.61  E-value: 1.27e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1308 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAqakaqaELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEEL 1387
Cdd:pfam05262  206 RESQEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNA------DKQRDEVRQKQQEAKNLPKPADTSSPKEDKQVAENQ 279
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1388 QHLRQSSEAEIQAKAQQVEAAERsrmrieeeirvvrlqletterqrggAEGELQALRARAEEAEAQKRqaQEEAERLRRQ 1467
Cdd:pfam05262  280 KREIEKAQIEIKKNDEEALKAKD-------------------------HKAFDLKQESKASEKEAEDK--ELEAQKKREP 332
                          170       180
                   ....*....|....*....|....*....
gi 254675251  1468 VQDESQR-KRQAEAElalrVKAEAEAARE 1495
Cdd:pfam05262  333 VAEDLQKtKPQVEAQ----PTSLNEDAID 357
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1596-1774 1.33e-03

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 44.55  E-value: 1.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1596 LERWQLKANEALRlrlQAEEVAQQKSLAQADAEKQkeeaerearrrgkAEEQAVRQRELAEQELEKQRQLAEgtaqqRLA 1675
Cdd:COG3064   106 LEKERLKAQEQQK---QAEEAEKQAQLEQKQQEEQ-------------ARKAAAEQKKKAEAAKAKAAAEAA-----KLK 164
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1676 AEQELIRLRAETEQGEQQRQLLEEELAR-LQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1754
Cdd:COG3064   165 AAAEAKKKAEEAAKAAEEAKAKAEAAAAkKKAEAEAKAAAEKAKAEAEAKAKAEKKAEAAAEEKAAAEKKKAAAKAKADK 244
                         170       180
                  ....*....|....*....|
gi 254675251 1755 EAEAgrfRELAEEAARLRAL 1774
Cdd:COG3064   245 AAAA---AKAAERKAAAAAL 261
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
1297-1475 1.33e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 44.13  E-value: 1.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1297 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEE---VARREEAA 1373
Cdd:pfam13868  159 EYLKEKAEREEEREAERREIKEEKEREIARLRAQQEKAQDEKAERDELRAKLYQEEQERKWRQKEREEAekkARQRQELQ 238
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1374 VDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLeTTERQRGGAEGELQALRARAEEAEAQ 1453
Cdd:pfam13868  239 QAREEQIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRREKRLEH-RRELEKQIEERERQRAAEREEELEEG 317
                          170       180
                   ....*....|....*....|..
gi 254675251  1454 KRQAQEEAERLRRqVQDESQRK 1475
Cdd:pfam13868  318 ERLREEEAERRER-IEEERQKK 338
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
1686-1818 1.38e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 44.61  E-value: 1.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1686 ETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELA 1765
Cdd:pfam05262  207 ESQEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEVRQKQQEAKNLPKPADTSSPKEDKQVAENQKREIEKA 286
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251  1766 EEAARLRA-------------LAEEAKRQRQLAEEDAARQRAEAERVlTEKLAAISEATRLKTEAE 1818
Cdd:pfam05262  287 QIEIKKNDeealkakdhkafdLKQESKASEKEAEDKELEAQKKREPV-AEDLQKTKPQVEAQPTSL 351
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
1647-2558 1.43e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 45.04  E-value: 1.43e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1647 QAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAeLAKVR 1726
Cdd:TIGR00606  200 QKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREIVKSYENELDPLKNRLKEIEHNLSKIMKLDNEIKA-LKSRK 278
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1727 AEMEVLLASKARAEEESRSTSEKSKQRLEAEAGR-FRELAEEAARLRALAEEAKRQRQLAEEDAA-------RQRAEAER 1798
Cdd:TIGR00606  279 KQMEKDNSELELKMEKVFQGTDEQLNDLYHNHQRtVREKERELVDCQRELEKLNKERRLLNQEKTellveqgRLQLQADR 358
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1799 VLTEKLAAISEATRLKTEAEIALKEKEAENERlrRLAEDEAFQRRRLEEQA---ALHKADIEERLAQLRKASESELERQK 1875
Cdd:TIGR00606  359 HQEHIRARDSLIQSLATRLELDGFERGPFSER--QIKNFHTLVIERQEDEAktaAQLCADLQSKERLKQEQADEIRDEKK 436
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1876 GLVEDTLRQRRQVEEEIMALKVSFEK----AAAGKAELELELGRIRSNAeDTMRSKEQAELEAARQRQLAAEEEQRRREA 1951
Cdd:TIGR00606  437 GLGRTIELKKEILEKKQEELKFVIKElqqlEGSSDRILELDQELRKAER-ELSKAEKNSLTETLKKEVKSLQNEKADLDR 515
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1952 EERvqrSLAAEEEAARQRKVALEEVERL-KAKVEEARRLRERAEQESARQLQLAQEAAQKRlQAEEKAHAF-----VVQQ 2025
Cdd:TIGR00606  516 KLR---KLDQEMEQLNHHTTTRTQMEMLtKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKK-QLEDWLHSKskeinQTRD 591
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2026 REEELQQTLQQEQNMLDRLRSEAEAARRAAEEAEEAREQAEREAAQSRKQVEEAERLKQSAEEQAQAQAQAQAAAEKLRK 2105
Cdd:TIGR00606  592 RLAKLNKELASLEQNKNHINNELESKEEQLSSYEDKLFDVCGSQDEESDLERLKEEIEKSSKQRAMLAGATAVYSQFITQ 671
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2106 EAEQEAARRAQAEQAALKQKQAADAEMEKHKKFAEQTLRQKaQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAA 2185
Cdd:TIGR00606  672 LTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLK-STESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELR 750
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2186 RQRSQVEEELFSVRVQMEELGKLKARIEAENRA--LILRDKDNTQRFLEEEAEKMKQVAEEAARL-----SVAAQEAARL 2258
Cdd:TIGR00606  751 NKLQKVNRDIQRLKNDIEEQETLLGTIMPEEESakVCLTDVTIMERFQMELKDVERKIAQQAAKLqgsdlDRTVQQVNQE 830
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2259 RQLAEEDL---AQQRALAEKMLKEKMQAVQEatrLKAEAELLQQQKELAQEQARRLQedkeQMAQQLVEETQGFQRTLEA 2335
Cdd:TIGR00606  831 KQEKQHELdtvVSKIELNRKLIQDQQEQIQH---LKSKTNELKSEKLQIGTNLQRRQ----QFEEQLVELSTEVQSLIRE 903
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2336 ERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQT-LEIQRQQSDHDAERLR 2414
Cdd:TIGR00606  904 IKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKVKNIHGYMKDIENKIQDgKDDYLKQKETELNTVN 983
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2415 EAIAELEREKEKLKQEAKLLQLKSEEMQtvQQEQILQETQALQKsfLSEKDSLLQRERfieqeKAKLEQLFQDEVAKAKQ 2494
Cdd:TIGR00606  984 AQLEECEKHQEKINEDMRLMRQDIDTQK--IQERWLQDNLTLRK--RENELKEVEEEL-----KQHLKEMGQMQVLQMKQ 1054
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251  2495 LReeqqrqqqqmeqekQELMASMEEARRRQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQR 2558
Cdd:TIGR00606 1055 EH--------------QKLEENIDLIKRNHVLALGRQKGYEKEIKHFKKELREPQFRDAEEKYR 1104
CH_FIMB_rpt1 cd21294
first calponin homology (CH) domain found in Saccharomyces cerevisiae fimbrin and similar ...
6-109 1.47e-03

first calponin homology (CH) domain found in Saccharomyces cerevisiae fimbrin and similar proteins; Fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409143  Cd Length: 125  Bit Score: 41.66  E-value: 1.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    6 DERDRVQkktFTKWVNK---------HLIKAQRHISDLYEDLRDGHNLISLLEvlsgDSLP-------------REKGRM 63
Cdd:cd21294     4 NEDERRE---FTKHINAvlagdpdvgSRLPFPTDTFQLFDECKDGLVLSKLIN----DSVPdtidervlnkpprKNKPLN 76
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 254675251   64 RFHKLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTII 109
Cdd:cd21294    77 NFQMIENNNIVINSAKAIGCSVVNIGAGDIIEGREHLILGLIWQII 122
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
1440-1529 1.55e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 44.82  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1440 LQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELalrvKAEAEaarekQRALQALDELRLQAEEAERRLRQ 1519
Cdd:PRK00409  525 LEELERELEQKAEEAEALLKEAEKLKEELEEKKEKLQEEEDKL----LEEAE-----KEAQQAIKEAKKEADEIIKELRQ 595
                          90
                  ....*....|
gi 254675251 1520 AEAERARQVQ 1529
Cdd:PRK00409  596 LQKGGYASVK 605
RmuC COG1322
DNA anti-recombination protein (rearrangement mutator) RmuC [Replication, recombination and ...
1308-1478 1.62e-03

DNA anti-recombination protein (rearrangement mutator) RmuC [Replication, recombination and repair];


Pssm-ID: 224241 [Multi-domain]  Cd Length: 448  Bit Score: 44.30  E-value: 1.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1308 RMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEEL 1387
Cdd:COG1322    14 LVNLAFIRQLLLRLGRLEQMLGELAAVLEQLLLLLAFRAEAEQLRTFARSLQALNLELIQELNELKARLQQQLLQSREQL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1388 QHLRQSseaeiQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQK-RQAQEEAERLRR 1466
Cdd:COG1322    94 QLLIES-----LAQLSSEFQELANEIFEELNRRLAELNQQNLKQLLKPLREVLEKFREQLEQRIHESaEERSTLLEEIDR 168
                         170
                  ....*....|..
gi 254675251 1467 QVQDESQRKRQA 1478
Cdd:COG1322   169 LLGEIQQLAQEA 180
Tektin pfam03148
Tektin family; Tektins are cytoskeletal proteins. They have been demonstrated in such cellular ...
1657-1935 1.71e-03

Tektin family; Tektins are cytoskeletal proteins. They have been demonstrated in such cellular sites as centrioles, basal bodies, and along ciliary and flagellar doublet microtubules. Tektins form unique protofilaments, organized as longitudinal polymers of tektin heterodimers with axial periodicity matching tubulin. Tektin polypeptides consist of several alpha-helical regions that are predicted to form coiled coils. Indeed, tektins share considerable structural similarities with intermediate filament proteins. Possible functional roles for tektins are: stabilisation of tubulin protofilaments; attachment of A and B-tubules in ciliary/flagellar microtubule doublets and C-tubules in centrioles; binding of axonemal components.


Pssm-ID: 427167 [Multi-domain]  Cd Length: 383  Bit Score: 44.07  E-value: 1.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1657 QELEKQRQLAEgtaQQRLAAE---QELIRLRAETEQGEQQRQllEEELARLQHEATAATQKRQELEAELAKVRAEMEVLL 1733
Cdd:pfam03148    3 ANNQELYREAE---AQRNDAErlrQESRRLRNETDAKTKWDQ--YDSNRRLGERIQDITFWKSELERELEELDEEIELLL 77
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1734 ASKARAEEESRSTSEK---SKQRLEAEAGRF----------RELAEEA-------ARLRALAEEAkrQRQLAEEDAARQR 1793
Cdd:pfam03148   78 EEKRRLEKALEALEEPlhiAQECLTLREKRQgidlvhdeveKELLKEVeliegiqELLQRTLEQA--WEQLRLLRAARHK 155
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1794 AEAErvLTEKLAAI---SEATRLK-TEAEIALKEKEAENERLRRLAED-EAFQRRRLEE-QAALHK-ADIEERLAQLRKA 1866
Cdd:pfam03148  156 LEKD--LSDKKEALeidEKCLSLNnTSPNISYKPGPTRIPPNSSTPETwEEFTQDNIERaEKERAAsAQLRELIDSILEQ 233
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251  1867 SESELERQKGLVEDTLRQRrqVEEEIMAlkvsfekaaagKAELELELGRIRSNAEDTmrSKEQAELEAA 1935
Cdd:pfam03148  234 TANDLRAQADAVNFALRKR--IEETEDA-----------KNKLEWQLKKTLQEIAEM--EKNIEALEKA 287
PRK11637 PRK11637
AmiB activator; Provisional
1610-1780 1.75e-03

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 44.30  E-value: 1.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1610 RLQAEEVAQQKSLA-QADAE-KQKEEAEREARRRGkaEEQAVRQRELA---------EQELEKQRQLAEGTAQQRLAAEQ 1678
Cdd:PRK11637  114 KLEQQQAAQERLLAaQLDAAfRQGEHTGLQLILSG--EESQRGERILAyfgylnqarQETIAELKQTREELAAQKAELEE 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1679 ELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEkskqrleaea 1758
Cdd:PRK11637  192 KQSQQKTLLYEQQAQQQKLEQARNERKKTLTGLESSLQKDQQQLSELRANESRLRDSIARAEREAKARAE---------- 261
                         170       180
                  ....*....|....*....|..
gi 254675251 1759 grfRElAEEAARLRALAEEAKR 1780
Cdd:PRK11637  262 ---RE-AREAARVRDKQKQAKR 279
tolA_full TIGR02794
TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the ...
2172-2380 1.77e-03

TolA protein; TolA couples the inner membrane complex of itself with TolQ and TolR to the outer membrane complex of TolB and OprL (also called Pal). Most of the length of the protein consists of low-complexity sequence that may differ in both length and composition from one species to another, complicating efforts to discriminate TolA (the most divergent gene in the tol-pal system) from paralogs such as TonB. Selection of members of the seed alignment and criteria for setting scoring cutoffs are based largely conserved operon struction. //The Tol-Pal complex is required for maintaining outer membrane integrity. Also involved in transport (uptake) of colicins and filamentous DNA, and implicated in pathogenesis. Transport is energized by the proton motive force. TolA is an inner membrane protein that interacts with periplasmic TolB and with outer membrane porins ompC, phoE and lamB. [Transport and binding proteins, Other, Cellular processes, Pathogenesis]


Pssm-ID: 274303 [Multi-domain]  Cd Length: 346  Bit Score: 44.07  E-value: 1.77e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2172 EELQRLKAEVTEAARQRSQVEEELfsvRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKM-----KQVAEEAA 2246
Cdd:TIGR02794   50 QQANRIQQQKKPAAKKEQERQKKL---EQQAEEAEKQRAAEQARQKELEQRAAAEKAAKQAEQAAKQaeekqKQAEEAKA 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2247 RLS---VAAQEAARLRQLAEEdlAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRlQEDKEQMAQQLV 2323
Cdd:TIGR02794  127 KQAaeaKAKAEAEAERKAKEE--AAKQAEEEAKAKAAAEAKKKAEEAKKKAEAEAKAKAEAEAKAKA-EEAKAKAEAAKA 203
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251  2324 EETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGE 2380
Cdd:TIGR02794  204 KAAAEAAAKAEAEAAAAAAAEAERKADEAELGDIFGLASGSNAEKQGGARGAAAGSE 260
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
1317-1424 1.81e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 44.43  E-value: 1.81e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1317 EQQRAEERERLAEVEAAL-----------EKQRQLAEAHAQAKAQAELEAQELQRRMQEEVA------RREEAAVDAQQQ 1379
Cdd:PRK00409  526 EELERELEQKAEEAEALLkeaeklkeeleEKKEKLQEEEDKLLEEAEKEAQQAIKEAKKEADeiikelRQLQKGGYASVK 605
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 254675251 1380 KRSIQEELQHLRQSSeaEIQAKAQQVEAAERSRMRIEEEIRVVRL 1424
Cdd:PRK00409  606 AHELIEARKRLNKAN--EKKEKKKKKQKEKQEELKVGDEVKYLSL 648
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
2131-2430 1.85e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 435008 [Multi-domain]  Cd Length: 329  Bit Score: 43.65  E-value: 1.85e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2131 EMEKHKKFAEQTLRQKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKA 2210
Cdd:pfam15905   60 ELKKKSQKDLKESKDQKELEKEIRALVQERGEQDKRLQALEEELEKVEAKLNAAVREKTSLSASVASLEKQLLELTRVNE 139
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2211 rieaenralILRDKdntqrFLEEEAEKmkqvaeeaaRLSVAAQEAARLRQLAEEDLAQQRALAEKMLKeKMQAVQeaTRL 2290
Cdd:pfam15905  140 ---------LLKAK-----FSEDGTQK---------KMSSLSMELMKLRNKLEAKMKEVMAKQEGMEG-KLQVTQ--KNL 193
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2291 KAEAELLQQQKELAQEQARRLQEDKEQmAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQR 2370
Cdd:pfam15905  194 EHSKGKVAQLEEKLVSTEKEKIEEKSE-TEKLLEYITELSCVSEQVEKYKLDIAQLEELLKEKNDEIESLKQSLEEKEQE 272
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2371 FRKQAEEIGEKLhrtELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQE 2430
Cdd:pfam15905  273 LSKQIKDLNEKC---KLLESEKEELLREYEEKEQTLNAELEELKEKLTLEEQEHQKLQQK 329
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
2174-2387 1.88e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 44.03  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2174 LQRLKAEVTEAARQRSQVEEElfsvrvQMEELGKLKARIEAENRALilrdkdNTQRFLEEEAEKMkqvAEEAARLSVAAQ 2253
Cdd:PRK09510   67 QQQQQKSAKRAEEQRKKKEQQ------QAEELQQKQAAEQERLKQL------EKERLAAQEQKKQ---AEEAAKQAALKQ 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2254 eaarlrQLAEEDLAQQRALAEKMLKEKMQAVQEATRlKAEAELLQQQKELAQEQAR-RLQEDKEQMAQQLVEETQGFQRT 2332
Cdd:PRK09510  132 ------KQAEEAAAKAAAAAKAKAEAEAKRAAAAAK-KAAAEAKKKAEAEAAKKAAaEAKKKAEAEAAAKAAAEAKKKAE 204
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 254675251 2333 LEAERQRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTEL 2387
Cdd:PRK09510  205 AEAKKKAAAEAKKKAAAEAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKAAAEV 259
PLN02939 PLN02939
transferase, transferring glycosyl groups
2139-2387 1.88e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 44.51  E-value: 1.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2139 AEQTLRQKAQVEQELTTLRLQLEETDHQK----------SILDEELQRLKAEVT-EAARQRSQVEEELFSVRVQMEELGK 2207
Cdd:PLN02939  158 LEKILTEKEALQGKINILEMRLSETDARIklaaqekihvEILEEQLEKLRNELLiRGATEGLCVHSLSKELDVLKEENML 237
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2208 LKARIEAENRALI-LRDKDNTQRFLEEEAEKMK-QVAEEAARLSVAAQEAARLRQLaeedlaQQRALAEKMlkEKMQAVQ 2285
Cdd:PLN02939  238 LKDDIQFLKAELIeVAETEERVFKLEKERSLLDaSLRELESKFIVAQEDVSKLSPL------QYDCWWEKV--ENLQDLL 309
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2286 EATRLKAE--AELLQQQKELaqeqarrlqEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQAR 2363
Cdd:PLN02939  310 DRATNQVEkaALVLDQNQDL---------RDKVDKLEASLKEANVSKFSSYKVELLQQKLKLLEERLQASDHEIHSYIQL 380
                         250       260
                  ....*....|....*....|....
gi 254675251 2364 AEEDAQRFRKQAEEIGEKLHRTEL 2387
Cdd:PLN02939  381 YQESIKEFQDTLSKLKEESKKRSL 404
COG4487 COG4487
Uncharacterized protein, contains DUF2130 domain [Function unknown];
1654-1848 1.89e-03

Uncharacterized protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 226889 [Multi-domain]  Cd Length: 438  Bit Score: 44.04  E-value: 1.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1654 LAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLL 1733
Cdd:COG4487    31 QIEQEDQSRILNTLEEFEKEANEKRAQYRSAKKKELSQLEEQLINQKKEQKNLFNEQIKQFELALQDEIAKLEALELLNL 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1734 ASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLTEKLAAISEAtrl 1813
Cdd:COG4487   111 EKDKELELLEKELDELSKELQKQLQNTAEIIEKKRENNKNEERLKFENEKKLEESLELEREKFEEQLHEANLDLEFK--- 187
                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 254675251 1814 ktEAEIALKEKEAENERLRRLAE--DEAFQRRRLEEQ 1848
Cdd:COG4487   188 --ENEEQRESKWAILKKLKRRAElgSQQVQGEALELP 222
GumC COG3206
Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell wall/membrane ...
2145-2338 1.91e-03

Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225747 [Multi-domain]  Cd Length: 458  Bit Score: 43.97  E-value: 1.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2145 QKAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALIlrdk 2224
Cdd:COG3206   212 QEAEAQVEDFRAQHGLTDAARGQLLSEQQLSALNTQLQSARARLAQAEARLASLLQLLPLGREAAALREVLESPTI---- 287
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2225 dntQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRAlaekmlkekmQAVQEATRLKAEAELLQQQKELA 2304
Cdd:COG3206   288 ---QDLRQQYAQVRQQIADLSTELGAKHPQLVALEAQLAELRQQIAA----------ELRQILASLPNELALLEQQEAAL 354
                         170       180       190
                  ....*....|....*....|....*....|....
gi 254675251 2305 QEQARRLQEDKEQMAQQLVEETQgFQRTLEAERQ 2338
Cdd:COG3206   355 EKELAQLKGRLSKLPKLQVQLRE-LEREAEAARS 387
PRK07353 PRK07353
F0F1 ATP synthase subunit B'; Validated
1307-1388 1.96e-03

F0F1 ATP synthase subunit B'; Validated


Pssm-ID: 235999 [Multi-domain]  Cd Length: 140  Bit Score: 41.53  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1307 RRMEEEERLAEQQRAEERERLAEVEA-ALEKQRQLAEAHAQAK---AQAELEAQELQRR-----MQEEVARREEAAVDAQ 1377
Cdd:PRK07353   32 KVVEEREDYIRTNRAEAKERLAEAEKlEAQYEQQLASARKQAQaviAEAEAEADKLAAEalaeaQAEAQASKEKARREIE 111
                          90
                  ....*....|.
gi 254675251 1378 QQKRSIQEELQ 1388
Cdd:PRK07353  112 QQKQAALAQLE 122
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
1439-1786 2.02e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 43.75  E-value: 2.02e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1439 ELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKA----EAEAAREKQRALQALDELRLQAEEAE 1514
Cdd:pfam13868    7 ELRELNSKLLAAKCNKERDAQIEEKKRIKAEEKEEERRLDEMMEEERERAleeeEEKEEERKEERKQYRQELEEQIEERE 86
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1515 RRlRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEehvtvaqlreeaerRAQQQAEAERAREEAER 1594
Cdd:pfam13868   87 QK-RQEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEIDE--------------FNEEQAKWKELEKEEEK 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1595 ELERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQELEKQRQLAEGTAQQRL 1674
Cdd:pfam13868  152 EEDLRILEYLKEKAEREEEREAERREIKEEKEREIARLRAQQEKAQDEKAERDELRAKLYQEEQERKWRQKEREEAEKKA 231
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1675 AAEQELIRLRAEteQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL 1754
Cdd:pfam13868  232 RQRQELQQAREE--QIELKERRLAEEAEREEEEFERMLRKQAEDEEIEQEEAEKRREKRLEHRRELEKQIEERERQRAAE 309
                          330       340       350
                   ....*....|....*....|....*....|..
gi 254675251  1755 EAEAGRFRELAEEAARLRALAEEAKRQRQLAE 1786
Cdd:pfam13868  310 REEELEEGERLREEEAERRERIEEERQKKLKE 341
PLEC smart00250
Plectin repeat;
2730-2766 2.06e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 38.62  E-value: 2.06e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 254675251   2730 KLLSAERAVTGYKDPYTGEQISLFQAMKKDLIVRDHG 2766
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLIDPETG 38
PRK01156 PRK01156
chromosome segregation protein; Provisional
2143-2440 2.08e-03

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 44.51  E-value: 2.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2143 LRQKAQVEQ-ELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIeaenralil 2221
Cdd:PRK01156  188 LEEKLKSSNlELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELSSLEDMKNRYESEI--------- 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2222 RDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQK 2301
Cdd:PRK01156  259 KTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDYFKYKNDIENKKQILSNIDAEINKYHAIIKKLSVLQKDY 338
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2302 ELAQEQARRLQEDKEQMAQQLVEET--QGFQRTLEAERQRQLEMSAEAERLKlrmAEMSRAQARAEEDAQRFRKQAEEIG 2379
Cdd:PRK01156  339 NDYIKKKSRYDDLNNQILELEGYEMdyNSYLKSIESLKKKIEEYSKNIERMS---AFISEILKIQEIDPDAIKKELNEIN 415
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2380 EKLHR--TELAT--QEKVTLVQTL-EIQR--------------------QQSDH-------DAERLREAIAELEREKEKL 2427
Cdd:PRK01156  416 VKLQDisSKVSSlnQRIRALRENLdELSRnmemlngqsvcpvcgttlgeEKSNHiinhyneKKSRLEEKIREIEIEVKDI 495
                         330
                  ....*....|...
gi 254675251 2428 KQEAKllQLKSEE 2440
Cdd:PRK01156  496 DEKIV--DLKKRK 506
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
2984-3021 2.09e-03

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 38.47  E-value: 2.09e-03
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 254675251  2984 LRGTNVIAGVWLEEAGQKLSIYEALKKDLLQPEVAVAL 3021
Cdd:pfam00681    2 LEAQAATGGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
PRK12678 PRK12678
transcription termination factor Rho; Provisional
1307-1477 2.09e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 44.12  E-value: 2.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1307 RRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAElEAQELQRRMQEEVARREEAAVDAQQQKRSIQEE 1386
Cdd:PRK12678   78 RRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPE-AAQARERRERGEAARRGAARKAGEGGEQPATEA 156
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1387 LQHLRQSSEAEIQAKAQQVEAAERSRMRieeeiRVVRLQLETTERQRGGaEGELQALRARAEEAEAQKRQAQEEAERLRR 1466
Cdd:PRK12678  157 RADAAERTEEEERDERRRRGDREDRQAE-----AERGERGRREERGRDG-DDRDRRDRREQGDRREERGRRDGGDRRGRR 230
                         170
                  ....*....|.
gi 254675251 1467 QVQDESQRKRQ 1477
Cdd:PRK12678  231 RRRDRRDARGD 241
COG1579 COG1579
Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function ...
1380-1517 2.16e-03

Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 224495 [Multi-domain]  Cd Length: 239  Bit Score: 43.12  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1380 KRSIQEELQHLRQSSEA---EIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGA---------EGELQALRARA 1447
Cdd:COG1579    26 IKEIRKALKKAKAELEAlnkALEALEIELEDLENQVSQLESEIQEIRERIKRAEEKLSAVkderelralNIEIQIAKERI 105
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675251 1448 EEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAEL-ALRVKAEAEAAREKQRALQALDELRLQAEEAERRL 1517
Cdd:COG1579   106 NSLEDELAELMEEIEKLEKEIEDLKERLERLEKNLaEAEARLEEEVAEIREEGQELSSKREELKEKLDPEL 176
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
2201-2499 2.23e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 43.75  E-value: 2.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2201 QMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEK 2280
Cdd:pfam13868   27 QIEEKKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKQYRQELEEQIEEREQKRQEEYEEKLQEREQMDEI 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2281 MQAVQEATRLKAEAELLQQQKELA--QEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMS 2358
Cdd:pfam13868  107 VERIQEEDQAEAEEKLEKQRQLREeiDEFNEEQAKWKELEKEEEKEEDLRILEYLKEKAEREEEREAERREIKEEKEREI 186
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2359 RAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQlks 2438
Cdd:pfam13868  187 ARLRAQQEKAQDEKAERDELRAKLYQEEQERKWRQKEREEAEKKARQRQELQQAREEQIELKERRLAEEAEREEEEF--- 263
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675251  2439 EEMQTVQQEQILQETQALQKSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQ 2499
Cdd:pfam13868  264 ERMLRKQAEDEEIEQEEAEKRREKRLEHRRELEKQIEERERQRAAEREEELEEGERLREEE 324
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
1646-1789 2.23e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 43.84  E-value: 2.23e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1646 EQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKV 1725
Cdd:pfam05262  209 QEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEVRQKQQEAKNLPKPADTSSPKEDKQVAENQKREIEKAQI 288
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251  1726 RAEM---EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLAEEDA 1789
Cdd:pfam05262  289 EIKKndeEALKAKDHKAFDLKQESKASEKEAEDKELEAQKKREPVAEDLQKTKPQVEAQPTSLNEDA 355
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
1852-2269 2.28e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 44.34  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1852 HKADIEERLAQlRKASESELERQKGLVEDTLRQ---RRQVEEEIMALKVSFEKAAAGKAELElelgrirsnaedTMRSKE 1928
Cdd:pfam17380  280 HQKAVSERQQQ-EKFEKMEQERLRQEKEEKAREverRRKLEEAEKARQAEMDRQAAIYAEQE------------RMAMER 346
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1929 QAELEAARQRQLAAeeeqrrreaeervqrslaaEEEAARQRKVALE-----EVERLKAKvEEARRLRERAEQESARQLQL 2003
Cdd:pfam17380  347 ERELERIRQEERKR-------------------ELERIRQEEIAMEisrmrELERLQME-RQQKNERVRQELEAARKVKI 406
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2004 AQEAAQKRLQAEEKAHAFVvqqreeelqqtlqqeqnmldrlrseaeaarraaeeaeeareqaereaaqsRKQVEEAERlk 2083
Cdd:pfam17380  407 LEEERQRKIQQQKVEMEQI--------------------------------------------------RAEQEEARQ-- 434
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2084 qsaeeqaqaqaqaqaaaEKLRKEAEQEAARRAQAEQAALKQKQaadaEMEKHKKFAEQTLRQKAQVEQElttLRLQLEET 2163
Cdd:pfam17380  435 -----------------REVRRLEEERAREMERVRLEEQERQQ----QVERLRQQEEERKRKKLELEKE---KRDRKRAE 490
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2164 DHQKSILDEELQRLKAEVTEAARQRSQVEEElfsvrvqMEELGKlkaRIEAENRALILRDKDNTQRFLEEE---AEKMKQ 2240
Cdd:pfam17380  491 EQRRKILEKELEERKQAMIEEERKRKLLEKE-------MEERQK---AIYEEERRREAEEERRKQQEMEERrriQEQMRK 560
                          410       420
                   ....*....|....*....|....*....
gi 254675251  2241 VAEEAARLSVAAQEAARLRQLAEEDLAQQ 2269
Cdd:pfam17380  561 ATEERSRLEAMEREREMMRQIVESEKARA 589
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
1297-1491 2.33e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 43.36  E-value: 2.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1297 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEevarreeaavda 1376
Cdd:pfam13868  156 RILEYLKEKAEREEEREAERREIKEEKEREIARLRAQQEKAQDEKAERDELRAKLYQEEQERKWRQKE------------ 223
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1377 QQQKRSIQEELQHLRQSSEAEIQAKAQQvEAAERSRMRIEEEiRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQ 1456
Cdd:pfam13868  224 REEAEKKARQRQELQQAREEQIELKERR-LAEEAEREEEEFE-RMLRKQAEDEEIEQEEAEKRREKRLEHRRELEKQIEE 301
                          170       180       190
                   ....*....|....*....|....*....|....*
gi 254675251  1457 AQEEAERLRRQVQDESQRKRQAEAELALRVKAEAE 1491
Cdd:pfam13868  302 RERQRAAEREEELEEGERLREEEAERRERIEEERQ 336
PTZ00491 PTZ00491
major vault protein; Provisional
2231-2369 2.41e-03

major vault protein; Provisional


Pssm-ID: 240439 [Multi-domain]  Cd Length: 850  Bit Score: 44.24  E-value: 2.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2231 LEEEA------EKMK-QVAEEAAR---LSVAAQEAARlrQLAEEDLAQQRALAEKMLKEkMQAVQEATRLKAEAELLQQQ 2300
Cdd:PTZ00491  675 LEQEArgrlerQKMHdKAKAEEQRtklLELQAESAAV--ESSGQSRAEALAEAEARLIE-AEAEVEQAELRAKALRIEAE 751
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251 2301 KELAQEQARRLQEDKEQmaQQLVEetqgfqrtLEAERQRQLeMSAEAERLKLRMAEMSR----AQARAEEDAQ 2369
Cdd:PTZ00491  752 AELEKLRKRQELELEYE--QAQNE--------LEIAKAKEL-ADIEATKFERIVEALGRetliAIARAGPELQ 813
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organisation of microtubules varies with the cell type and is ...
1304-1431 2.57e-03

MAP7 (E-MAP-115) family; The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilizing protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 428577 [Multi-domain]  Cd Length: 153  Bit Score: 41.54  E-value: 2.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1304 ETLRRMEEEERLAEQQRA-EERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQEL-QRRMQEEVARREEAAVDAQQQKR 1381
Cdd:pfam05672   11 EAARILAEKRRQAREQRErEEQERLEKEEEERLRREELRRRAEEERARREEEARRLeEERKREEEERQRKAEEEAEEKEQ 90
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 254675251  1382 SIQEELQHLRQSSEAeiqAKAQQVEAAErsRMRIEEEIRVVRLQLETTER 1431
Cdd:pfam05672   91 REKEEQERLQKQKEE---AEAKAREEAE--RQRQEREKIMQQEEQERLER 135
CH_PLS_FIM_rpt2 cd21218
second calponin homology (CH) domain found in the plastin/fimbrin family; This family includes ...
18-108 2.59e-03

second calponin homology (CH) domain found in the plastin/fimbrin family; This family includes plastin and fimbrin. Plastin has three isoforms, plastin-1, -2, and -3, which are all actin-bundling proteins. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, LC64P, or lymphocyte cytosolic protein 1 (LCP-1), plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Fimbrin has been found in plants and fungi. Arabidopsis thaliana fimbrin (AtFIM) includes fimbrin-1, -2, -3, -4, and -5; they cross-link actin filaments (F-actin) in a calcium independent manner. They stabilize and prevent F-actin depolymerization mediated by profilin. They act as key regulators of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus. AtFIM5 is an actin bundling factor that is required for pollen germination and pollen tube growth. Fungal fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409067  Cd Length: 114  Bit Score: 40.36  E-value: 2.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251   18 KWVNKHLIKAQR---HISDLYEDLRDGHNLISLLEVLSGDSLPREKGRM---RFHKLQNVQIALDYLRhrQVKLVN-IRN 90
Cdd:cd21218    17 RWVNYHLKKAGPtkkRVTNFSSDLKDGEVYALLLHSLAPELCDKELVLEvlsEEDLEKRAEKVLQAAE--KLGCKYfLTP 94
                          90
                  ....*....|....*...
gi 254675251   91 DDIADGNPKLTLGLIWTI 108
Cdd:cd21218    95 EDIVSGNPRLNLAFVATL 112
CH_PLS2_rpt3 cd21330
third calponin homology (CH) domain found in plastin-2; Plastin-2, also called L-plastin, or ...
7-115 2.64e-03

third calponin homology (CH) domain found in plastin-2; Plastin-2, also called L-plastin, or LC64P, or lymphocyte cytosolic protein 1 (LCP-1), is an actin-binding protein that plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-2 contains four copies of the CH domain. This model corresponds to the third CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409179  Cd Length: 125  Bit Score: 40.74  E-value: 2.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    7 ERDRVQKKTFTKWVNKhlIKAQRHISDLYEDLRDGHNLISLLEVL---------SGDSLPREKGRMRfhKLQNVQIALDY 77
Cdd:cd21330     9 EGETREERTFRNWMNS--LGVNPRVNHLYSDLSDALVIFQLYEKIkvpvdwnrvNKPPYPKLGENMK--KLENCNYAVEL 84
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 254675251   78 LRHR-QVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS 115
Cdd:cd21330    85 GKNKaKFSLVGIAGQDLNEGNRTLTLALIWQLMRRYTLN 123
COG5283 COG5283
Phage-related tail protein [Mobilome: prophages, transposons];
1309-1555 2.65e-03

Phage-related tail protein [Mobilome: prophages, transposons];


Pssm-ID: 227608 [Multi-domain]  Cd Length: 1213  Bit Score: 44.15  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1309 MEEEERLAEQQRAEERERLAEVEAALEKQ-RQLAEAHAQAKAQAEL------EAQELQRRM-QEEVARRE-EAAVD-AQQ 1378
Cdd:COG5283    41 LEKQQKLTKDGLSASKGKYEGLSEAMEKQkKAYEDLKQEVKEVNRAtqaskkAYQEYNAQYtQAENKLRSlSGQFGvASE 120
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1379 QKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQ-------ALRARAEEAE 1451
Cdd:COG5283   121 QLMLQQKEIQRLQYAISTLNKSMAAQARLLEQTGNKFGTADAKVVGLRESFGRQTEALNKQLErtkkvadALTYVLDEAQ 200
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1452 AQKRQAQEEA-ERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQrALQALDELRLQAEEAERRLRQAEAERARQVQV 1530
Cdd:COG5283   201 QKLSQALSARlERLQESRTQMSQSSGQLGKRLETDKAGAGALGLLGA-ALAGSFAAIGAAVRRTAQMNGELMDKTKQVKG 279
                         250       260
                  ....*....|....*....|....*..
gi 254675251 1531 ALETAQRSAEV--ELQSKRASFAEKTA 1555
Cdd:COG5283   280 ARDNLGKVTSQgeEMSDAIQETAEHIK 306
COG4487 COG4487
Uncharacterized protein, contains DUF2130 domain [Function unknown];
2259-2448 2.66e-03

Uncharacterized protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 226889 [Multi-domain]  Cd Length: 438  Bit Score: 43.65  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2259 RQLAEEDLAQQRALAEKMLKEKMQAVQEATrlkaeaELLQQQKELAQEQARRLQEDKEQmaQQLVEETQGFQRTLEAERQ 2338
Cdd:COG4487    28 RYKQIEQEDQSRILNTLEEFEKEANEKRAQ------YRSAKKKELSQLEEQLINQKKEQ--KNLFNEQIKQFELALQDEI 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2339 RQLEMSAE--AERLKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTE----LATQEKVTLVQTLEIQRQQSDHDAER 2412
Cdd:COG4487   100 AKLEALELlnLEKDKELELLEKELDELSKELQKQLQNTAEIIEKKRENNKneerLKFENEKKLEESLELEREKFEEQLHE 179
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 254675251 2413 LREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQ 2448
Cdd:COG4487   180 ANLDLEFKENEEQRESKWAILKKLKRRAELGSQQVQ 215
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
1423-1724 2.67e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 43.36  E-value: 2.67e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1423 RLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQA 1502
Cdd:pfam13868   33 RIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKQYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERIQE 112
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1503 LDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQLERTLQEE--HVTVAQLREEAERRAQ 1580
Cdd:pfam13868  113 EDQAEAEEKLEKQRQLREEIDEFNEEQAKWKELEKEEEKEEDLRILEYLKEKAEREEEREAErrEIKEEKEREIARLRAQ 192
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1581 QQAEAERAREEAERELERWQLKANEALRLRLQAEE---VAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQ 1657
Cdd:pfam13868  193 QEKAQDEKAERDELRAKLYQEEQERKWRQKEREEAekkARQRQELQQAREEQIELKERRLAEEAEREEEEFERMLRKQAE 272
                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 254675251  1658 ELEKQRQLAEGTAQQRLAAEQELIRLRAETEQgeQQRQLLEEELARLQHEATAATQKRQELEAELAK 1724
Cdd:pfam13868  273 DEEIEQEEAEKRREKRLEHRRELEKQIEERER--QRAAEREEELEEGERLREEEAERRERIEEERQK 337
EVC2_like pfam12297
Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. ...
2309-2487 2.70e-03

Ellis van Creveld protein 2 like protein; This family of proteins is found in eukaryotes. Proteins in this family are typically between 571 and 1310 amino acids in length. There are two conserved sequence motifs: LPA and ELH. EVC2 is implicated in Ellis van Creveld chondrodysplastic dwarfism in humans. Mutations in this protein can give rise to this congenital condition. LIMBIN is a protein which shares around 80% sequence homology with EVC2 and it is implicated in a similar condition in bovine chondrodysplastic dwarfism.


Pssm-ID: 432462 [Multi-domain]  Cd Length: 429  Bit Score: 43.50  E-value: 2.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2309 RRLQEDKE-QMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRA----------QARAEEDAQRFRKQAEE 2377
Cdd:pfam12297  210 GRLQEEYGrKMAALAAECNLETREKMEAQHQKEMAEKEEAEELLQHASEQEALecsslldklhKLEQEHLQRSLLLKQEE 289
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2378 IGEKLHRtELATQEKVTLvqtLEIQRQQsdhdaerLREAIAELEREKEKLKQeakLLQLKSEEMQTVqqEQILQETQALQ 2457
Cdd:pfam12297  290 EFAKARR-QLAVKRRVEL---HKIFFEQ-------LKEATRKGELKEEAAKR---LLHDYSKIQDTI--EELMDFFQANQ 353
                          170       180       190
                   ....*....|....*....|....*....|
gi 254675251  2458 KSFLSEKdslLQRERFIEQEKAKLEQLFQD 2487
Cdd:pfam12297  354 RYHLEER---FAQREYLVKSLQSLETHISA 380
PRK12704 PRK12704
phosphodiesterase; Provisional
2364-2488 2.74e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.61  E-value: 2.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2364 AEEDAQRFRKQAEEigeklhRTELATQEKVTLVQTlEIQRQQSDHDAErLREAIAELEREKEKLKQEAKLLQLKSEEMQt 2443
Cdd:PRK12704   36 AEEEAKRILEEAKK------EAEAIKKEALLEAKE-EIHKLRNEFEKE-LRERRNELQKLEKRLLQKEENLDRKLELLE- 106
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 254675251 2444 vQQEQILQEtqalqksflsEKDSLLQRERFIEQEKAKLEQLFQDE 2488
Cdd:PRK12704  107 -KREEELEK----------KEKELEQKQQELEKKEEELEELIEEQ 140
COG4372 COG4372
Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];
1605-1783 2.79e-03

Uncharacterized conserved protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 226809 [Multi-domain]  Cd Length: 499  Bit Score: 43.86  E-value: 2.79e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1605 EALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARRRGKAEEQAVRQRELAEQeLEKQRQLAEGTAQQRLAAEQEL---- 1680
Cdd:COG4372   103 EREAARSELQKARQEREAVRQELAAARQNLAKAQQELARLTKQAQDLQTRLKT-LAEQRRQLEAQAQSLQASQKQLqasa 181
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1681 -------IRLRAETEQGEQQrqllEEELARLQHEATAATQKRQELEAELAKVRAEMEVL------LASKARAEEESRSTS 1747
Cdd:COG4372   182 tqlksqvLDLKLRSAQIEQE----AQNLATRANAAQARTEELARRAAAAQQTAQAIQQRdaqisqKAQQIAARAEQIRER 257
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 254675251 1748 EKSKQRLEAEAGRfreLAEEAARLRALAEEAKRQRQ 1783
Cdd:COG4372   258 ERQLQRLETAQAR---LEQEVAQLEAYYQAYVRLRQ 290
SPEC smart00150
Spectrin repeats;
487-581 2.88e-03

Spectrin repeats;


Pssm-ID: 197544 [Multi-domain]  Cd Length: 101  Bit Score: 40.01  E-value: 2.88e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    487 LRYLQDLLAWVEENQRRIDSAEWGVDLPSVEAQLGSHRGMHQSIEEFRAKIERARNDESQL---SPATRGAYRDCLGRLD 563
Cdd:smart00150    4 LRDADELEAWLEEKEQLLASEDLGKDLESVEALLKKHEAFEAELEAHEERVEALNELGEQLieeGHPDAEEIEERLEELN 83
                            90
                    ....*....|....*...
gi 254675251    564 LQYAKLLNSSKARLRSLE 581
Cdd:smart00150   84 ERWEELKELAEERRQKLE 101
ERM pfam00769
Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at ...
1307-1432 2.98e-03

Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at their amino terminus. This family represents the rest of these proteins.


Pssm-ID: 425860 [Multi-domain]  Cd Length: 247  Bit Score: 42.62  E-value: 2.98e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1307 RRMEEEERLaeQQRAEERERlaeVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSiQEE 1386
Cdd:pfam00769    7 EKQELEERL--KQYEEETRK---AQEELEESEETAELLEEKLRVAEEEAELLEQKAQEAEEEKERLEESAEMEAEE-KEQ 80
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*.
gi 254675251  1387 LQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQ 1432
Cdd:pfam00769   81 LERELREAQEEVARLEEESERKEEEAERLQEELEEAREEEEEAKEK 126
COG5281 COG5281
Phage-related minor tail protein [Mobilome: prophages, transposons];
1659-1903 3.25e-03

Phage-related minor tail protein [Mobilome: prophages, transposons];


Pssm-ID: 227606 [Multi-domain]  Cd Length: 833  Bit Score: 43.86  E-value: 3.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1659 LEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLE-EELARLqheATAATQKRQELEAELAKVRAEMEVLlaska 1737
Cdd:COG5281   345 LGIGREDKQAALLAAKLAAEKLARVTAQGALNARLKLAQDdLTQAEL---NYAAADQAANQEGALNAREDEAEVL----- 416
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1738 RAEEESRSTSEKSKQRLEAEAGRFRELAEEAARLRALAEEAKRQRQLaeEDAARQRAEAERvlteKLAAISEATRLKTEA 1817
Cdd:COG5281   417 STQEERRDILKNLLADAEKRTARQEELNKALAKAKILQADKAAKAYQ--EDILQREAQSRG----KTAAAERSQEQMTAA 490
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1818 EIALKEKEAENERLRRLAEDEAFQRRRLeeqaalHKADIEERLAQLrKASESELERQKGLVE---DTLRQRRQVEEEIMA 1894
Cdd:COG5281   491 LKALLAFQQQIADLSGAKEKASDQKSLL------WKAEEQYALLKE-EAKQRQLQEQKALLEhkkETLEYTSQLAELLDQ 563

                  ....*....
gi 254675251 1895 LKVSFEKAA 1903
Cdd:COG5281   564 QADRFELSA 572
EmrA COG1566
Multidrug resistance efflux pump [Defense mechanisms];
1314-1430 3.46e-03

Multidrug resistance efflux pump [Defense mechanisms];


Pssm-ID: 224482 [Multi-domain]  Cd Length: 352  Bit Score: 43.09  E-value: 3.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1314 RLA-EQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQ-ELQRRM---QEEVARREEAAvDAQQQKRSIQEELQ 1388
Cdd:COG1566    90 RAAlEQAEAALAAAEAQLRNLRAQLASAQALIAQAEAQDLDQAQnELERRAelaQRGVVSREELD-RARAALQAAEAALA 168
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 254675251 1389 HLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTE 1430
Cdd:COG1566   169 AAQAAQKQNLALLESEVSGAQAQVASAEAALDQAKLDLERTV 210
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
1596-1858 3.69e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 42.98  E-value: 3.69e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1596 LERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQKEEAEREARR-----RGKAEEQAVRQRELAEQELEKQRQLAEGTA 1670
Cdd:pfam13868   65 EERKEERKQYRQELEEQIEEREQKRQEEYEEKLQEREQMDEIVERiqeedQAEAEEKLEKQRQLREEIDEFNEEQAKWKE 144
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1671 QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEEsrstsEKS 1750
Cdd:pfam13868  145 LEKEEEKEEDLRILEYLKEKAEREEEREAERREIKEEKEREIARLRAQQEKAQDEKAERDELRAKLYQEEQE-----RKW 219
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1751 KQRLEAEAGRFRELAEEAARLRALAEEAKRQRQlaEEDAARQRAEAERVLT------EKLAAISEATRLKTEAEIALKEK 1824
Cdd:pfam13868  220 RQKEREEAEKKARQRQELQQAREEQIELKERRL--AEEAEREEEEFERMLRkqaedeEIEQEEAEKRREKRLEHRRELEK 297
                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 254675251  1825 EAENERLRRLAEDEAF--QRRRLEEQAALHKADIEE 1858
Cdd:pfam13868  298 QIEERERQRAAEREEEleEGERLREEEAERRERIEE 333
PRK09039 PRK09039
peptidoglycan -binding protein;
2203-2320 3.74e-03

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 43.03  E-value: 3.74e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2203 EELGKLKARIEAENRALILRDKDNTQrfLEEeaekmkQVAEEAARLSVAAQEAARLRQLAEEdLAQQRALAEKMLKEKMQ 2282
Cdd:PRK09039   53 SALDRLNSQIAELADLLSLERQGNQD--LQD------SVANLRASLSAAEAERSRLQALLAE-LAGAGAAAEGRAGELAQ 123
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 254675251 2283 AVQEATRLKAEA----ELLQQQKELAQEQARRLQ--------EDKEQMAQ 2320
Cdd:PRK09039  124 ELDSEKQVSARAlaqvELLNQQIAALRRQLAALEaaldasekRDRESQAK 173
SPFH_like_u3 cd03406
Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This ...
1302-1403 3.80e-03

Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.


Pssm-ID: 259804 [Multi-domain]  Cd Length: 293  Bit Score: 42.67  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1302 ISETLRR----MEEEE-RLAeqqRAEERERLAEVEAALEKQRQLAEAHAQAKA-----QAELEAQELQRRMQE-----EV 1366
Cdd:cd03406   160 IPEAIRRnyeaMEAEKtKLL---IAEQHQKVVEKEAETERKRAVIEAEKDAEVakiqmQQKIMEKEAEKKISEiedemHL 236
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 254675251 1367 ArREEAAVDAQQQKRSIQEELQHLRQSSE----AEIQAKAQ 1403
Cdd:cd03406   237 A-REKARADAEYYRALREAEANKLKLTPEylelKKYQAIAN 276
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1773-2008 3.80e-03

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 43.01  E-value: 3.80e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1773 ALAEEAKRQRQlaeedaarQRAEAERVLTEKLaaiseaTRLKTEAEIALKEKEAENERLRRLAEDeafqrrRLEEQAALH 1852
Cdd:COG3064    59 AVVQQYGRIQS--------QQSSAKKGEQQRK------KKEEQVAEELKPKQAAEQERLKQLEKE------RLKAQEQQK 118
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1853 KADIEERLAQLRKASESELERQKGLvedtlRQRRQVEEEIMALKVSFEKAAAgKAELELELGRIRSNAEDTMRSKEQAEL 1932
Cdd:COG3064   119 QAEEAEKQAQLEQKQQEEQARKAAA-----EQKKKAEAAKAKAAAEAAKLKA-AAEAKKKAEEAAKAAEEAKAKAEAAAA 192
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 1933 EAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALeeverlKAKVEEARRLRERAEQESARqlQLAQEAA 2008
Cdd:COG3064   193 KKKAEAEAKAAAEKAKAEAEAKAKAEKKAEAAAEEKAAAEK------KKAAAKAKADKAAAAAKAAE--RKAAAAA 260
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
2221-2394 3.82e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 43.07  E-value: 3.82e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2221 LRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQ 2300
Cdd:pfam05262  177 ISDKKVVEALREDNEKGVNFRRDMTDLKERESQEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADKQRDEVRQKQQE 256
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2301 KELAQEQAR--------RLQEDKEQMAQQLVEETQgfQRTLEAERQRQlemsAEAERLKLRMAEMSRAQARAEEDAQRFR 2372
Cdd:pfam05262  257 AKNLPKPADtsspkedkQVAENQKREIEKAQIEIK--KNDEEALKAKD----HKAFDLKQESKASEKEAEDKELEAQKKR 330
                          170       180
                   ....*....|....*....|..
gi 254675251  2373 kqaEEIGEKLHRTELATQEKVT 2394
Cdd:pfam05262  331 ---EPVAEDLQKTKPQVEAQPT 349
PRK12704 PRK12704
phosphodiesterase; Provisional
2258-2432 3.85e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 43.23  E-value: 3.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2258 LRQLAEEDLAQQRALAEKMLKEkmqavqeatrlkAEAELLQQQKELAQEQARRLQEDKEQMAQQLVEETQGFQRTLEAER 2337
Cdd:PRK12704   25 RKKIAEAKIKEAEEEAKRILEE------------AKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLL 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2338 QRQLEMSAEAERLKLRMAEMSRAQARAEEDAQRFRKQAEEIgEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAI 2417
Cdd:PRK12704   93 QKEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEEL-EELIEEQLQELERISGLTAEEAKEILLEKVEEEARHEA 171
                         170
                  ....*....|....*.
gi 254675251 2418 AELEREKEKL-KQEAK 2432
Cdd:PRK12704  172 AVLIKEIEEEaKEEAD 187
PRK12678 PRK12678
transcription termination factor Rho; Provisional
1393-1527 3.95e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 43.35  E-value: 3.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1393 SSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERlRRQVQDES 1472
Cdd:PRK12678   69 TPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARR-GAARKAGE 147
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 254675251 1473 QRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQ 1527
Cdd:PRK12678  148 GGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERGRREERGRDGDD 202
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
2203-2458 4.10e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 435008 [Multi-domain]  Cd Length: 329  Bit Score: 42.88  E-value: 4.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2203 EELGKLKaRIEAENRALILR--DKDNTQRFLEEEAEKM--KQVAEEAARLSVAAQEAARLRQLAE----EDLAQQRAlAE 2274
Cdd:pfam15905   70 KESKDQK-ELEKEIRALVQErgEQDKRLQALEEELEKVeaKLNAAVREKTSLSASVASLEKQLLEltrvNELLKAKF-SE 147
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2275 KMLKEKMQAVQ-EATRLKAEAELLQQQKELAQEQarrlQEDKEQMAQQLVEETQG----FQRTLEAERQRQLEMSAEAER 2349
Cdd:pfam15905  148 DGTQKKMSSLSmELMKLRNKLEAKMKEVMAKQEG----MEGKLQVTQKNLEHSKGkvaqLEEKLVSTEKEKIEEKSETEK 223
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2350 LKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKlhrtelaTQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQ 2429
Cdd:pfam15905  224 LLEYITELSCVSEQVEKYKLDIAQLEELLKEK-------NDEIESLKQSLEEKEQELSKQIKDLNEKCKLLESEKEELLR 296
                          250       260       270
                   ....*....|....*....|....*....|
gi 254675251  2430 EAKLL-QLKSEEMQTVqQEQILQETQALQK 2458
Cdd:pfam15905  297 EYEEKeQTLNAELEEL-KEKLTLEEQEHQK 325
MAP7 pfam05672
MAP7 (E-MAP-115) family; The organisation of microtubules varies with the cell type and is ...
1335-1466 4.20e-03

MAP7 (E-MAP-115) family; The organisation of microtubules varies with the cell type and is presumably controlled by tissue-specific microtubule-associated proteins (MAPs). The 115-kDa epithelial MAP (E-MAP-115/MAP7) has been identified as a microtubule-stabilizing protein predominantly expressed in cell lines of epithelial origin. The binding of this microtubule associated protein is nucleotide independent.


Pssm-ID: 428577 [Multi-domain]  Cd Length: 153  Bit Score: 40.77  E-value: 4.20e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1335 EKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHL--RQSSEAEIQAKAQQVEAAERSR 1412
Cdd:pfam05672   11 EAARILAEKRRQAREQREREEQERLEKEEEERLRREELRRRAEEERARREEEARRLeeERKREEEERQRKAEEEAEEKEQ 90
                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 254675251  1413 MRIEEEIRVVRLQLETTERQRGGAEGELQalraraeeaEAQKRQAQEEAERLRR 1466
Cdd:pfam05672   91 REKEEQERLQKQKEEAEAKAREEAERQRQ---------EREKIMQQEEQERLER 135
DUF3523 pfam12037
Domain of unknown function (DUF3523); This presumed domain is functionally uncharacterized. ...
1643-1783 4.25e-03

Domain of unknown function (DUF3523); This presumed domain is functionally uncharacterized. This domain is found in eukaryotes. This domain is typically between 257 to 277 amino acids in length. This domain is found associated with pfam00004. This domain has a conserved LER sequence motif.


Pssm-ID: 432279 [Multi-domain]  Cd Length: 264  Bit Score: 42.27  E-value: 4.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1643 KAEEQaVRQRELAEQELEKQRQLAEG-TAQQRLAAEQELIRLRAETEQgEQQRQLLEEELARLQHEATAATQKRQELEA- 1720
Cdd:pfam12037   52 KKQEQ-TRQAELQAKIKEYEAAQEQLeIERQRVEYEERRKTLQEETKQ-KQQRAQYQDELARKRYQDQLEAQRRRNEELl 129
                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251  1721 ----ELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEAEA-GRFRELAE-EAARLRALAEEAKRQRQ 1783
Cdd:pfam12037  130 rmqeESVAKQEAMRIQAQRRQTEEHEAELRRETEMAKAEAEAeARAKEEREnEDLNLEQLREKANEERE 198
PRK12678 PRK12678
transcription termination factor Rho; Provisional
1341-1529 4.30e-03

transcription termination factor Rho; Provisional


Pssm-ID: 237171 [Multi-domain]  Cd Length: 672  Bit Score: 43.35  E-value: 4.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1341 AEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIR 1420
Cdd:PRK12678   67 AATPAAPAAAARRAARAAAAARQAEQPAAEAAAAKAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAARKAG 146
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1421 vvRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQvqDESQRKRQAE-AELALRVKAEAEAAREKQRA 1499
Cdd:PRK12678  147 --EGGEQPATEARADAAERTEEEERDERRRRGDREDRQAEAERGERG--RREERGRDGDdRDRRDRREQGDRREERGRRD 222
                         170       180       190
                  ....*....|....*....|....*....|
gi 254675251 1500 LQALDELRLQAEEAERRLRQAEAERARQVQ 1529
Cdd:PRK12678  223 GGDRRGRRRRRDRRDARGDDNREDRGDRDG 252
PLN03188 PLN03188
kinesin-12 family protein; Provisional
1304-1488 4.51e-03

kinesin-12 family protein; Provisional


Pssm-ID: 215621 [Multi-domain]  Cd Length: 1320  Bit Score: 43.38  E-value: 4.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1304 ETLRRMEEEER---LAEQQRAEererLAEVEAALEKQRQlaEAHAQAKAQAELE-----AQELQRRMQEEVARREEAAVD 1375
Cdd:PLN03188 1052 ERLRWTEAESKwisLAEELRTE----LDASRALAEKQKH--ELDTEKRCAEELKeamqmAMEGHARMLEQYADLEEKHIQ 1125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1376 AQQQKRSIQEELQHLRQSSE------AE---IQAKAQQVEA----AERSRMRIEEEIRVVRLQLETTER--QRGG----- 1435
Cdd:PLN03188 1126 LLARHRRIQEGIDDVKKAAAragvrgAEskfINALAAEISAlkveREKERRYLRDENKSLQAQLRDTAEavQAAGellvr 1205
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 1436 ---AEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKA 1488
Cdd:PLN03188 1206 lkeAEEALTVAQKRAMDAEQEAAEAYKQIDKLKRKHENEISTLNQLVAESRLPKEA 1261
ERM pfam00769
Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at ...
1645-1742 4.62e-03

Ezrin/radixin/moesin family; This family of proteins contain a band 4.1 domain (pfam00373), at their amino terminus. This family represents the rest of these proteins.


Pssm-ID: 425860 [Multi-domain]  Cd Length: 247  Bit Score: 41.85  E-value: 4.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1645 EEQAVRQRELAEQE-----LEKQRQLAEGTA----QQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKR 1715
Cdd:pfam00769   20 EETRKAQEELEESEetaelLEEKLRVAEEEAelleQKAQEAEEEKERLEESAEMEAEEKEQLERELREAQEEVARLEEES 99
                           90       100
                   ....*....|....*....|....*..
gi 254675251  1716 QELEAELAKVRAEMEvllasKARAEEE 1742
Cdd:pfam00769  100 ERKEEEAERLQEELE-----EAREEEE 121
mukB PRK04863
chromosome partition protein MukB;
1648-2005 4.89e-03

chromosome partition protein MukB;


Pssm-ID: 235316 [Multi-domain]  Cd Length: 1486  Bit Score: 43.41  E-value: 4.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1648 AVRQRELAEQELEKQRQLAEgtAQQRLAAEQE-LIRLRAETEQGEQQRQLLEEEL----ARLQ--HEATAATQKRQELEA 1720
Cdd:PRK04863  278 ANERRVHLEEALELRRELYT--SRRQLAAEQYrLVEMARELAELNEAESDLEQDYqaasDHLNlvQTALRQQEKIERYQA 355
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1721 ELAKVraemevllasKARAEEESRSTSEKSKQRLEAEAgRFRELAEEAARLR--------ALAEEAKRQRQLAEEDAARQ 1792
Cdd:PRK04863  356 DLEEL----------EERLEEQNEVVEEADEQQEENEA-RAEAAEEEVDELKsqladyqqALDVQQTRAIQYQQAVQALE 424
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1793 RAE------------AERVLTEKLAAISEATRLKTEAEIALKEKEAENER-------LRRLAED----EAFQR-----RR 1844
Cdd:PRK04863  425 RAKqlcglpdltadnAEDWLEEFQAKEQEATEELLSLEQKLSVAQAAHSQfeqayqlVRKIAGEvsrsEAWDVarellRR 504
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1845 LEEQAALhkadiEERLAQLRkASESELERQkglvedtLRQRRQVEEeimaLKVSFEKAAAGKAELELELGRIRSNAEDTM 1924
Cdd:PRK04863  505 LREQRHL-----AEQLQQLR-MRLSELEQR-------LRQQQRAER----LLAEFCKRLGKNLDDEDELEQLQEELEARL 567
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1925 RSKEQaELEAARQRQLAAEEEQRRREAEERVQRSLAAEEEAARQRKVALEE-------------------VERLKAKVEE 1985
Cdd:PRK04863  568 ESLSE-SVSEARERRMALRQQLEQLQARIQRLAARAPAWLAAQDALARLREqsgeefedsqdvteymqqlLERERELTVE 646
                         410       420
                  ....*....|....*....|
gi 254675251 1986 ARRLRERAEQESARQLQLAQ 2005
Cdd:PRK04863  647 RDELAARKQALDEEIERLSQ 666
PLEC smart00250
Plectin repeat;
3389-3420 4.95e-03

Plectin repeat;


Pssm-ID: 197605  Cd Length: 38  Bit Score: 37.46  E-value: 4.95e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 254675251   3389 KLLSAEKAVTGYKDPYSGNTISLFQAMKKGLV 3420
Cdd:smart00250    2 RLLEAQSAIGGIIDPETGQKLSVEEALRRGLI 33
PRK11637 PRK11637
AmiB activator; Provisional
2197-2377 4.99e-03

AmiB activator; Provisional


Pssm-ID: 236942 [Multi-domain]  Cd Length: 428  Bit Score: 42.76  E-value: 4.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2197 SVRVQMEE----LGKLKARIEAENRA-LILRDKDNTQRFLEEEAEKMK------QVAEEAARLSVAAQEAARLRQLAEED 2265
Cdd:PRK11637   62 SVRQQQQQraslLAQLKKQEEAISQAsRKLRETQNTLNQLNKQIDELNasiaklEQQQAAQERLLAAQLDAAFRQGEHTG 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2266 LAQQRALAEKMLKEKMQA----VQEAtRLKAEAELLQQQKELAQEqaRRLQEDKEQMAQQLVEETQGFQRTLE---AERQ 2338
Cdd:PRK11637  142 LQLILSGEESQRGERILAyfgyLNQA-RQETIAELKQTREELAAQ--KAELEEKQSQQKTLLYEQQAQQQKLEqarNERK 218
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251 2339 RQL---------------EMSAEAERLKLRMAEMSR-AQARAEE---DAQRFRKQAEE 2377
Cdd:PRK11637  219 KTLtglesslqkdqqqlsELRANESRLRDSIARAEReAKARAERearEAARVRDKQKQ 276
Borrelia_P83 pfam05262
Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.
2256-2431 5.10e-03

Borrelia P83/100 protein; This family consists of several Borrelia P83/P100 antigen proteins.


Pssm-ID: 114011 [Multi-domain]  Cd Length: 489  Bit Score: 42.68  E-value: 5.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2256 ARLRQLAEEDLAQQRAL-------AEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRlQEDKEQMAQQLVEETQG 2328
Cdd:pfam05262  184 EALREDNEKGVNFRRDMtdlkereSQEDAKRAQQLKEELDKKQIDADKAQQKADFAQDNADK-QRDEVRQKQQEAKNLPK 262
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2329 FQRTLEAERQRQLemsaeAERLKlrmAEMSRAQARAEEDAQRFRKQAEEIGEKLHRtELATQEKVTLVQTLEIQRQQSDh 2408
Cdd:pfam05262  263 PADTSSPKEDKQV-----AENQK---REIEKAQIEIKKNDEEALKAKDHKAFDLKQ-ESKASEKEAEDKELEAQKKREP- 332
                          170       180
                   ....*....|....*....|...
gi 254675251  2409 DAERLREAIAELEREKEKLKQEA 2431
Cdd:pfam05262  333 VAEDLQKTKPQVEAQPTSLNEDA 355
DUF4207 pfam13904
Domain of unknown function (DUF4207); This family is found in eukaryotes; it has several ...
1304-1408 5.16e-03

Domain of unknown function (DUF4207); This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 433570 [Multi-domain]  Cd Length: 223  Bit Score: 41.62  E-value: 5.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1304 ETLRRMEEEERLAEQQRAEERERLAE--VEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDA----- 1376
Cdd:pfam13904   71 QKELQAQKEEREKEEQEAELRKRLAKekYQEWLQRKARQQTKKREESHKQKAAESASKSLAKPERKVSQEEAKEVlqewe 150
                           90       100       110
                   ....*....|....*....|....*....|....*
gi 254675251  1377 ---QQQKRSIQEELQHLRQSSEAEIQAKAQQVEAA 1408
Cdd:pfam13904  151 lkkLEQQQRKREEEQREQLKKEEEEQERKQLAEKA 185
PRK05035 PRK05035
electron transport complex protein RnfC; Provisional
2228-2440 5.16e-03

electron transport complex protein RnfC; Provisional


Pssm-ID: 235334 [Multi-domain]  Cd Length: 695  Bit Score: 43.01  E-value: 5.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2228 QRFleeEAEKMKQVAEEAARLSVAAQEAARLRqlAEEDLAQQRALAEkmLKEKmQAVQEATRLKAEAELLQQQKELAQEQ 2307
Cdd:PRK05035  453 ARF---EARQARLEREKAAREARHKKAAEARA--AKDKDAVAAALAR--VKAK-KAAATQPIVIKAGARPDNSAVIAARE 524
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2308 ARRLQEDKEQMAQQLVEETQGFQRTLEAERQR-------QLEMSAEAE-----RLKLRMAEMSRAQAR-AEEDAQRFRKQ 2374
Cdd:PRK05035  525 ARKAQARARQAEKQAAAAADPKKAAVAAAIARakakkaaQQAANAEAEeevdpKKAAVAAAIARAKAKkAAQQAASAEPE 604
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 2375 AEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEE 2440
Cdd:PRK05035  605 EQVAEVDPKKAAVAAAIARAKAKKAEQQANAEPEEPVDPRKAAVAAAIARAKARKAAQQQANAEPE 670
MscK COG3264
Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];
1602-1806 5.25e-03

Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225803 [Multi-domain]  Cd Length: 835  Bit Score: 43.14  E-value: 5.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1602 KANEALRLRLQAEEVAQQKSLAQADAEKQKEEaerearrrGKAEEQAVRQRELAEQELEKQRQLAegtaqqrlaaeQELI 1681
Cdd:COG3264    15 SRRELLTAESAQLEAALQLLQEAVNSKRQEEA--------EPAAEEAELQAELIQQELAINDQLS-----------QALN 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1682 RLRAETEQGEQQRQLLEEELARL-QHEATAATQKrQELEAELAKVRAemevLLASKARAEEEsrstsEKSKQRLEAEAGR 1760
Cdd:COG3264    76 QQTERLNALASDDRQLANLLLQLlQSSRTIREQI-AVLRGSLLLSRI----LLQQLGPLPEA-----GQPQEQFEVTQER 145
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 254675251 1761 fRELAEEAARLRALAEEAK----RQRQLAEEDAARQRAEAERVLTEKLAA 1806
Cdd:COG3264   146 -DALQAEKAYINALEGQAEqltaEVRDILDQILDTRRELLNSLLSQREAI 194
EzrA pfam06160
Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like ...
1191-1519 5.38e-03

Septation ring formation regulator, EzrA; During the bacterial cell cycle, the tubulin-like cell-division protein FtsZ polymerizes into a ring structure that establishes the location of the nascent division site. EzrA modulates the frequency and position of FtsZ ring formation.


Pssm-ID: 428797 [Multi-domain]  Cd Length: 542  Bit Score: 42.92  E-value: 5.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1191 AKRRQEQIQAVpIANCQAAREQLRQE-KALLEEIERHGEKVEECQKfakQYINAIKdyelQLITYKAQLEPVASPAkkpk 1269
Cdd:pfam06160   84 AKKALDEIEEL-LDDIEEDIKQILEElDELLESEEKNREEVEELKD---KYRELRK----TLLANRFSYGPAIDEL---- 151
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1270 vqsgsESVIQEYVDLRTRYSELTTlTSQYIKfISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQ-RQLAEAHAQAK 1348
Cdd:pfam06160  152 -----EKQLAEIEEEFSQFEELTE-SGDYLE-AREVLEKLEEETDALEELMEDIPPLYEELKTELPDQlEELKEGYREME 224
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1349 AQ--------AELEAQELQRRMQEEVARREEAAVD-AQQQKRSIQEELQHLRQSSEAEIQAKA----------QQVEAAE 1409
Cdd:pfam06160  225 EEgyalehlnVDKEIQQLEEQLEENLALLENLELDeAEEALEEIEERIDQLYDLLEKEVDAKKyveknlpeieDYLEHAE 304
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1410 RSRMRIEEEIRVV----RLQLETTERQRgGAEGELQALRARAEEAE---AQKRQA----QEEAERLRRQVQD-ESQRKRQ 1477
Cdd:pfam06160  305 EQNKELKEELERVqqsyTLNENELERVR-GLEKQLEELEKRYDEIVerlEEKEVAyselQEELEEILEQLEEiEEEQEEF 383
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 254675251  1478 AEAELALRvkaeaeaaREKQRALQALDELRLQAEEAERRLRQ 1519
Cdd:pfam06160  384 KESLQSLR--------KDELEAREKLDEFKLELREIKRLVEK 417
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
1799-2012 5.56e-03

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 42.63  E-value: 5.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1799 VLTEKLAAISEATRLKTEAEIAlkeKEAENERLRRLaedeafqrRRLEEQAALHKADIEERLAQLRKASESELERQKGLV 1878
Cdd:COG3064    53 VMVDPGAVVQQYGRIQSQQSSA---KKGEQQRKKKE--------EQVAEELKPKQAAEQERLKQLEKERLKAQEQQKQAE 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1879 E-DTLRQRRQVEEEIMALKVSFEK-----AAAGKAELELELGRIRSNAEDTMRSKEQAELEAARQRQLAAEEEQRRREAE 1952
Cdd:COG3064   122 EaEKQAQLEQKQQEEQARKAAAEQkkkaeAAKAKAAAEAAKLKAAAEAKKKAEEAAKAAEEAKAKAEAAAAKKKAEAEAK 201
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1953 ERVQRSLAAEEEAARQRKVALEEVERLKAKVEEARRLRERAEQESARQLQLAQEAAQKRL 2012
Cdd:COG3064   202 AAAEKAKAEAEAKAKAEKKAEAAAEEKAAAEKKKAAAKAKADKAAAAAKAAERKAAAAAL 261
Caldesmon pfam02029
Caldesmon;
1351-1751 5.70e-03

Caldesmon;


Pssm-ID: 426572 [Multi-domain]  Cd Length: 490  Bit Score: 42.55  E-value: 5.70e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1351 AELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQhlRQSSEAEIQAKAQQVEAAErsrmriEEEIRVVRLQLETTE 1430
Cdd:pfam02029    3 EEEAARERRRRAREERRRQKESEEPSSQEDSQPEVNAQ--EEAEEEDSELKPSGQGGLD------EEEAFLDRTAKREER 74
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1431 RQRGGAEGELqalraRAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQA 1510
Cdd:pfam02029   75 RQKRLQEALE-----RQKELDPTITDEQASKPRSTENTPEEKNNTEEEEKSSTRKERYEIEEREVSEKSYEKDDKKAVPK 149
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1511 EEAERRLRQAEAERARQVQVALETAQRSAEVELQSKRASFAEKTAQL-----ERTLQEEHVTVAQlreeaerraqqqaea 1585
Cdd:pfam02029  150 EEEEEEDAKTEEEEEEEEEEKKVSKKKKEKLKDEYTSKVFLDQKKGHpeqksQNGALEEVTSMTV--------------- 214
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1586 erareeaerelerwQLKANEALRLRLQAEEVAQQKSLAQADAEKqkeeaerearrrgKAEEQAVRQRELAEQELEKQRQl 1665
Cdd:pfam02029  215 --------------KLKRTERTFSQKSLVAEDEEEGAAFLEAEQ-------------KLEELRRRRQEKESQEFEKLRQ- 266
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1666 aegtAQQRLAAEQELIRLRAEteqgEQQRQLLEEELARLQHEATAATQKRQE---LEAELAKVRAEmevllASKARAEEE 1742
Cdd:pfam02029  267 ----KQQEAELELEELKKKRE----ERRKILEEEEQRRKQEEAERKAREEEEkrrMKEEIERRRAE-----AAEKRQKME 333

                   ....*....
gi 254675251  1743 SRSTSEKSK 1751
Cdd:pfam02029  334 DTSSAEGKK 342
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
1437-1630 5.78e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 42.49  E-value: 5.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1437 EGELQALRARAEEAEAQKRQAQEEAERLRRQvqdESQRKRQAEAELALRVKAEAEAAREKQRAlqaldELRLQAEEAERR 1516
Cdd:PRK09510   84 KEQQQAEELQQKQAAEQERLKQLEKERLAAQ---EQKKQAEEAAKQAALKQKQAEEAAAKAAA-----AAKAKAEAEAKR 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1517 LrqaeAERARQvqvALETAQRSAEVELQSKRASFAEKTAQLERTLQEEHVTVAQLREEAERRAQQQAEAERAReeaerel 1596
Cdd:PRK09510  156 A----AAAAKK---AAAEAKKKAEAEAAKKAAAEAKKKAEAEAAAKAAAEAKKKAEAEAKKKAAAEAKKKAAA------- 221
                         170       180       190
                  ....*....|....*....|....*....|....
gi 254675251 1597 ERWQLKANEALRLRLQAEEVAQQKSLAQADAEKQ 1630
Cdd:PRK09510  222 EAKAAAAKAAAEAKAAAEKAAAAKAAEKAAAAKA 255
GumC COG3206
Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell wall/membrane ...
2143-2366 6.18e-03

Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225747 [Multi-domain]  Cd Length: 458  Bit Score: 42.43  E-value: 6.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2143 LRQKAQVEQELTTLRLQLEETDHQK----SILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRA 2218
Cdd:COG3206   143 LLESLKVLRAGRSRVIELSYTSNDPklaaKLANALAQAYLADQLEAQLEAFRRASDSLDERLEELRARLQEAEAQVEDFR 222
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2219 LILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE-----DLAQQRALAEKMLKEKMQAvQEATRLKAE 2293
Cdd:COG3206   223 AQHGLTDAARGQLLSEQQLSALNTQLQSARARLAQAEARLASLLQLlplgrEAAALREVLESPTIQDLRQ-QYAQVRQQI 301
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 2294 AELLQQQKEL---AQEQARRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRAQARAEE 2366
Cdd:COG3206   302 ADLSTELGAKhpqLVALEAQLAELRQQIAAELRQILASLPNELALLEQQEAALEKELAQLKGRLSKLPKLQVQLRE 377
TolA COG3064
Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];
2232-2432 6.33e-03

Membrane protein involved in colicin uptake [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225606 [Multi-domain]  Cd Length: 387  Bit Score: 42.24  E-value: 6.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2232 EEEAEKMKQVAEEAARLSVAAQEaaRLRQLAEEDLAQQralaekmlkEKMQAVQEATRLKAEAEllQQQKELAQEQARRL 2311
Cdd:COG3064    79 QQRKKKEEQVAEELKPKQAAEQE--RLKQLEKERLKAQ---------EQQKQAEEAEKQAQLEQ--KQQEEQARKAAAEQ 145
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2312 QEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAErlklrmaemsrAQARAEEdAQRFRKQAEEIGEKLHRTELATQE 2391
Cdd:COG3064   146 KKKAEAAKAKAAAEAAKLKAAAEAKKKAEEAAKAAEE-----------AKAKAEA-AAAKKKAEAEAKAAAEKAKAEAEA 213
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 254675251 2392 KVTlvqtleiqrqqsdhdAERLREAIAELEREKEKLKQEAK 2432
Cdd:COG3064   214 KAK---------------AEKKAEAAAEEKAAAEKKKAAAK 239
PspA_IM30 pfam04012
PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent ...
1301-1524 6.37e-03

PspA/IM30 family; This family includes PspA a protein that suppresses sigma54-dependent transcription. The PspA protein, a negative regulator of the Escherichia coli phage shock psp operon, is produced when virulence factors are exported through secretins in many Gram-negative pathogenic bacteria and its homolog in plants, VIPP1, plays a critical role in thylakoid biogenesis, essential for photosynthesis. Activation of transcription by the enhancer-dependent bacterial sigma(54) containing RNA polymerase occurs through ATP hydrolysis-driven protein conformational changes enabled by activator proteins that belong to the large AAA(+) mechanochemical protein family. It has been shown that PspA directly and specifically acts upon and binds to the AAA(+) domain of the PspF transcription activator.


Pssm-ID: 281941 [Multi-domain]  Cd Length: 218  Bit Score: 41.21  E-value: 6.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1301 FISETLRRMEEEERLAEQQRAEERERLAEVEaalekqRQLAEAHAQAKaQAELEAQELQRRMQEEVARREEAAVDAQQQk 1380
Cdd:pfam04012   13 NIHEGLDKAEDPEKMLEQAIRDMQSELGKAR------QALAQVIARQK-QLERKLEEQKEQAKKLENKARAALTKGNEE- 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1381 rsiqeelqhLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEE 1460
Cdd:pfam04012   85 ---------LAREALAEIATLEKLAEALETQLTQQRSAVEQLRKQLAALETKIQQLKAKKTALKARLKAAKAQEAVNTSL 155
                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251  1461 AERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRaLQALDELRLQAEEAERRLRQAEAER 1524
Cdd:pfam04012  156 GSASTESATDSFERIEEKIEEREARADAAAELASAQDL-DAKLEAAGIQMEVSEDVLARLKAEQ 218
CH_PARVA_rpt2 cd21337
second calponin homology (CH) domain found in alpha-parvin; Alpha-parvin, also called ...
5-113 6.45e-03

second calponin homology (CH) domain found in alpha-parvin; Alpha-parvin, also called actopaxin, calponin-like integrin-linked kinase-binding protein (CH-ILKBP), or matrix-remodeling-associated protein 2, plays a role in sarcomere organization and in smooth muscle cell contraction. It is required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. It is also involved in the reorganization of the actin cytoskeleton, the formation of lamellipodia and ciliogenesis, as well as in the establishement of cell polarity, cell adhesion, cell spreading, and directed cell migration. Alpha-parvin contains two copies of the CH domain. This model corresponds to the second CH domain. CH domains are actin filament (F-actin) binding motifs.


Pssm-ID: 409186  Cd Length: 129  Bit Score: 39.98  E-value: 6.45e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    5 PDERDrVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPREKGRMR----FHKLQNVQIALDYLRH 80
Cdd:cd21337    15 PDKLN-VVKKTLITFVNKHLNKLNLEVTELETQFADGVYLVLLMGLLEGYFVPLHSFFLTpdsfEQKVLNVSFAFELMQD 93
                          90       100       110
                  ....*....|....*....|....*....|...
gi 254675251   81 RQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQ 113
Cdd:cd21337    94 GGLEKPKPRPEDIVNCDLKSTLRVLYNLFTKYR 126
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
2298-2432 6.52e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 42.10  E-value: 6.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2298 QQQKELAQEQARRLQEDKEQMAQQLVEETQgfQRTLEAERQRQLEMSAEAERLKLRMAEMSR------AQARAEEDAQRF 2371
Cdd:PRK09510   79 EQRKKKEQQQAEELQQKQAAEQERLKQLEK--ERLAAQEQKKQAEEAAKQAALKQKQAEEAAakaaaaAKAKAEAEAKRA 156
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254675251 2372 R---KQAEEIGEKLHRTELATQEKVTLVQTLEIQ-RQQSDHDAERLREAIAelereKEKLKQEAK 2432
Cdd:PRK09510  157 AaaaKKAAAEAKKKAEAEAAKKAAAEAKKKAEAEaAAKAAAEAKKKAEAEA-----KKKAAAEAK 216
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
2402-2624 6.62e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.80  E-value: 6.62e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2402 QRQQSDH----DAERLREAIAELEREKEKLKQEAKLLQLKSEEMQtvQQEQILQEtqalQKSFLSEKDSLLQRERfIEQE 2477
Cdd:pfam17380  286 ERQQQEKfekmEQERLRQEKEEKAREVERRRKLEEAEKARQAEMD--RQAAIYAE----QERMAMERERELERIR-QEER 358
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2478 KAKLEQLFQDEVAKAKQLREEQQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQ 2557
Cdd:pfam17380  359 KRELERIRQEEIAMEISRMRELERLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREVR 438
                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 254675251  2558 RLRE----RLQRLEEEHRAALAHSEIATTQAASTKALPNGRDApdgpsvEAEPEYTFEGLRQKVPAQQLQE 2624
Cdd:pfam17380  439 RLEEerarEMERVRLEEQERQQQVERLRQQEEERKRKKLELEK------EKRDRKRAEEQRRKILEKELEE 503
COG4487 COG4487
Uncharacterized protein, contains DUF2130 domain [Function unknown];
1303-1484 6.71e-03

Uncharacterized protein, contains DUF2130 domain [Function unknown];


Pssm-ID: 226889 [Multi-domain]  Cd Length: 438  Bit Score: 42.50  E-value: 6.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1303 SETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQ-----LAEAHAQAKAQAELEAQELQRRMQEE---VARREEAAV 1374
Cdd:COG4487    38 SRILNTLEEFEKEANEKRAQYRSAKKKELSQLEEQLInqkkeQKNLFNEQIKQFELALQDEIAKLEALellNLEKDKELE 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1375 DAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRvvrlqlETTERQRGGAEGELQALRARAEEAEAQK 1454
Cdd:COG4487   118 LLEKELDELSKELQKQLQNTAEIIEKKRENNKNEERLKFENEKKLE------ESLELEREKFEEQLHEANLDLEFKENEE 191
                         170       180       190
                  ....*....|....*....|....*....|..
gi 254675251 1455 RQA--QEEAERLRRQVQDESQRKRQAEAELAL 1484
Cdd:COG4487   192 QREskWAILKKLKRRAELGSQQVQGEALELPN 223
PRK07735 PRK07735
NADH-quinone oxidoreductase subunit C;
1318-1512 6.75e-03

NADH-quinone oxidoreductase subunit C;


Pssm-ID: 236081 [Multi-domain]  Cd Length: 430  Bit Score: 42.27  E-value: 6.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1318 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAE 1397
Cdd:PRK07735   76 KQKREGTEEVTEEEKAKAKAKAAAAAKAKAAALAKQKREGTEEVTEEEKAAAKAKAAAAAKAKAAALAKQKREGTEEVTE 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1398 IQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDES-QRKR 1476
Cdd:PRK07735  156 EEEETDKEKAKAKAAAAAKAKAAALAKQKAAEAGEGTEEVTEEEKAKAKAKAAAAAKAKAAALAKQKASQGNGDSgDEDA 235
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 254675251 1477 QAEAELALRVKAEAeAAREKQRALQALDELRLQAEE 1512
Cdd:PRK07735  236 KAKAIAAAKAKAAA-AARAKTKGAEGKKEEEPKQEE 270
Nop14 pfam04147
Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the ...
1688-1849 6.93e-03

Nop14-like family; Emg1 and Nop14 are novel proteins whose interaction is required for the maturation of the 18S rRNA and for 40S ribosome production.


Pssm-ID: 427745  Cd Length: 836  Bit Score: 42.61  E-value: 6.93e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1688 EQGEQQRQLLEEELARLQHEATAATQKrqELEAELAKVRAEM--EVLLASKARAEEesrstseKSKQRLEAEAGRFR--- 1762
Cdd:pfam04147  128 DSEEEEDGQLDAKRVRRAHFGGGEDDE--EEEPERKKSKKEVmeEVIAKSKLHKYE-------RQKAKEEDEELREEldk 198
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1763 ELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAE-----RVLT-EKLAAISEatRLKTEAEIALKEKE----AENERLR 1832
Cdd:pfam04147  199 ELKDLRSLLSGSKRPKPEQAKKPEEKPDRKKPDDDydklvRELAfDKRAKPSD--RTKTEEELAEEEKErlekLEEERLR 276
                          170       180
                   ....*....|....*....|..
gi 254675251  1833 RL-----AEDEAFQRRRLEEQA 1849
Cdd:pfam04147  277 RMrgeedEEEEEGKKKKKHKSA 298
PRK12704 PRK12704
phosphodiesterase; Provisional
1321-1496 7.00e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 42.46  E-value: 7.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1321 AEERERLAEVEAalekQRQLAEAHAQAKA---QAELEAQELQRRMQEEvarreeaavdAQQQKRSIQEELQHLrqssEAE 1397
Cdd:PRK12704   29 AEAKIKEAEEEA----KRILEEAKKEAEAikkEALLEAKEEIHKLRNE----------FEKELRERRNELQKL----EKR 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1398 IQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERqrggaegELQALRARAEEAEAQKRQA--------QEEA-ERLRRQV 1468
Cdd:PRK12704   91 LLQKEENLDRKLELLEKREEELEKKEKELEQKQQ-------ELEKKEEELEELIEEQLQElerisgltAEEAkEILLEKV 163
                         170       180
                  ....*....|....*....|....*...
gi 254675251 1469 QDEsqrkrqAEAELALRVKAEAEAAREK 1496
Cdd:PRK12704  164 EEE------ARHEAAVLIKEIEEEAKEE 185
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
1448-1565 7.00e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 42.51  E-value: 7.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1448 EEAeaqKRQAQEEAERLRRQVQDESQRKRQAEAELAlrvkaeaEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQ 1527
Cdd:PRK00409  505 EEA---KKLIGEDKEKLNELIASLEELERELEQKAE-------EAEALLKEAEKLKEELEEKKEKLQEEEDKLLEEAEKE 574
                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 254675251 1528 VQVALETAQRSAEVELQSKRASFAEKTAQL-ERTLQEEH 1565
Cdd:PRK00409  575 AQQAIKEAKKEADEIIKELRQLQKGGYASVkAHELIEAR 613
Plectin pfam00681
Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous ...
4245-4275 7.08e-03

Plectin repeat; This family includes repeats from plectin, desmoplakin, envoplakin and bullous pemphigoid antigen.


Pssm-ID: 425816  Cd Length: 39  Bit Score: 36.93  E-value: 7.08e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 254675251  4245 AGILDTETLEKVSITEAMHRNLVDNITGQRL 4275
Cdd:pfam00681    9 GGIIDPVTGERLSVEEALKRGLIDPETAQKL 39
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
1114-1482 7.26e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 429718 [Multi-domain]  Cd Length: 488  Bit Score: 42.18  E-value: 7.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1114 LRDELRGAQEVGERLQQRHGERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLgrqLRYYRESADPLSAWLQDAKR 1193
Cdd:pfam07888   32 LQNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEE---LRQSREKVEELEEKYKELSR 108
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1194 RQEQIQAVPIANCQAAREQLRQEKALLEEIERHGEKV-------EECQKFAKQYINAIKDYELQLITYKAQLEPVASPAK 1266
Cdd:pfam07888  109 SGEELAEEKDALLAQRAESEARIRELEEDIKTLTQRVleretelERMKERVKKAGAQRKEEEAERKQLQAKLQQTEEELR 188
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1267 K--PKVQSGSESVIQEYVDLRTRYSELTTLTSqyiKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAH 1344
Cdd:pfam07888  189 SlsKEFQELRNSLAQRDTQVLQLQDTITTLTQ---KLTTAHRKEAENEALLEELRSLQERLNASERKVEGLGEELSSMAA 265
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1345 AQAKAQAELEAQELQrrMQEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERSRMRIEEEiRVVRL 1424
Cdd:pfam07888  266 QRDRTQAELHQARLQ--AAQLTLQLADASLALREGRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEE-RMERE 342
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251  1425 QLETT-ERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAEL 1482
Cdd:pfam07888  343 KLEVElGREKDCNRVQLSESRRELQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQRL 401
SAC6 COG5069
Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton];
5-140 7.31e-03

Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton];


Pssm-ID: 227401 [Multi-domain]  Cd Length: 612  Bit Score: 42.62  E-value: 7.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251    5 PDERDRVQKKTFTKWVNKHLIKAQrhISDLYEDLRDGHNLISLLEVLSGD---SLPREKGR-------MRFHKLQNVQIA 74
Cdd:COG5069   373 FDAEGEFEARVFTFWLNSLDVSPE--ITNLFGDLRDQLILLQALSKKLMPmtvTHKLVKKQpasgieeNRFKAFENENYA 450
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251   75 LDYLRHRQVKLVNIRNDDIADGNpKLTLGLIW-------TIILHFQISDiqvsgqsEDMTAKEKLLLWSQRMV 140
Cdd:COG5069   451 VDLGITEGFSLVGIKGLEILDGI-RLKLTLVWqvlrsntALFNHVLKKD-------GCGLSDSDLCAWLGSLG 515
MscK COG3264
Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];
2253-2462 7.36e-03

Small-conductance mechanosensitive channel [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225803 [Multi-domain]  Cd Length: 835  Bit Score: 42.37  E-value: 7.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2253 QEAARLRQLAEEDLAQQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQAR--RLQEDKEQMAQQLVEETQGfQ 2330
Cdd:COG3264    10 QELLQSRRELLTAESAQLEAALQLLQEAVNSKRQEEAEPAAEEAELQAELIQQELAIndQLSQALNQQTERLNALASD-D 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2331 RTLEAERQR--QLEMSAEAERLKLRMA-EMSRA----QARAEEDAQrfRKQAEEIGEKlhRTELATQEkvTLVQTLEIQR 2403
Cdd:COG3264    89 RQLANLLLQllQSSRTIREQIAVLRGSlLLSRIllqqLGPLPEAGQ--PQEQFEVTQE--RDALQAEK--AYINALEGQA 162
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251 2404 QQSDHDAERLREAIAELERekEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQKSFLS 2462
Cdd:COG3264   163 EQLTAEVRDILDQILDTRR--ELLNSLLSQREAISLQLNQQQLSAASDELRSLLHQQSF 219
COG1340 COG1340
Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];
2170-2450 7.43e-03

Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown];


Pssm-ID: 224259 [Multi-domain]  Cd Length: 294  Bit Score: 41.59  E-value: 7.43e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2170 LDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKDNTQRFLEEEAEKmkqvAEEAARLS 2249
Cdd:COG1340    11 LELKRKQLKEEIEELKEKRDELRKEASELAEKRDELNAKVRELREKAQELREERDEINEEVQELKEKR----DEINAKLQ 86
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2250 VAAQEAARLRQLAEEDLAQQR---ALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQE-QARRLQEDKEQMAQQLVEE 2325
Cdd:COG1340    87 ELRKEYRELKEKRNEFNLGGRsikSLEREIERLEKKQQTSVLTPEEERELVQKIKELRKElEDAKKALEENEKLKELKAE 166
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2326 TQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSraqaraeEDAQRFRKQAEEIGEK-LHRTELATQEKVTLVQTL-EIQR 2403
Cdd:COG1340   167 IDELKKKAREIHEKIQELANEAQEYHEEMIKLF-------EEADELRKEADELHEEfVELSKKIDELHEEFRNLQnELRE 239
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 254675251 2404 QQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQEQIL 2450
Cdd:COG1340   240 LEKKIKALRAKEKAAKRREKREELKERAEEIYEKFKRGEKLTTEELL 286
GumC COG3206
Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell wall/membrane ...
1605-1811 7.53e-03

Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 225747 [Multi-domain]  Cd Length: 458  Bit Score: 42.05  E-value: 7.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1605 EALRLRLQAEEVAQQKSLAQADAE-KQKEEAEREARRRGKAEEQAVRQRELAEQE-----LEKQRQLAEGTAQQRLAAEQ 1678
Cdd:COG3206   205 EELRARLQEAEAQVEDFRAQHGLTdAARGQLLSEQQLSALNTQLQSARARLAQAEarlasLLQLLPLGREAAALREVLES 284
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1679 ELI-RLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRLEae 1757
Cdd:COG3206   285 PTIqDLRQQYAQVRQQIADLSTELGAKHPQLVALEAQLAELRQQIAAELRQILASLPNELALLEQQEAALEKELAQLK-- 362
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 1758 aGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQR--AEAERVLTEKLAAISEAT 1811
Cdd:COG3206   363 -GRLSKLPKLQVQLRELEREAEAARSLYETLLQRYQelSIQEASPIGNARVISPAV 417
PLN02316 PLN02316
synthase/transferase
1493-1547 7.89e-03

synthase/transferase


Pssm-ID: 215180 [Multi-domain]  Cd Length: 1036  Bit Score: 42.55  E-value: 7.89e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 254675251 1493 AREKQRALQaldelRLQAEEAERRlRQAEAERARQVQVALETAQRS-AEVELQSKR 1547
Cdd:PLN02316  251 LEEKRRELE-----KLAKEEAERE-RQAEEQRRREEEKAAMEADRAqAKAEVEKRR 300
COG1579 COG1579
Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function ...
1255-1419 8.06e-03

Predicted nucleic acid-binding protein, contains Zn-ribbon domain [General function prediction only];


Pssm-ID: 224495 [Multi-domain]  Cd Length: 239  Bit Score: 41.20  E-value: 8.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1255 KAQLEPVASPAKK--PKVQSGSESVIQEYVDLRTRYSELTTLTSQyikfISETLRRMEE-EERLAEQQRAEERERLAEve 1331
Cdd:COG1579    19 KDRLEPRIKEIRKalKKAKAELEALNKALEALEIELEDLENQVSQ----LESEIQEIRErIKRAEEKLSAVKDERELR-- 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1332 aALEKQRQLAEahaQAKAQAELEAQELQrrmqEEVARREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERS 1411
Cdd:COG1579    93 -ALNIEIQIAK---ERINSLEDELAELM----EEIEKLEKEIEDLKERLERLEKNLAEAEARLEEEVAEIREEGQELSSK 164

                  ....*...
gi 254675251 1412 RMRIEEEI 1419
Cdd:COG1579   165 REELKEKL 172
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
2131-2539 8.06e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 435022 [Multi-domain]  Cd Length: 1112  Bit Score: 42.40  E-value: 8.06e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2131 EMEKHKKFAEQTLRQKAQVEQELttlRLQLEETDHQ----KSILDEELQRLKAEVTEAAR---QRSQVEEELFSVRVQME 2203
Cdd:pfam15921  121 EMQMERDAMADIRRRESQSQEDL---RNQLQNTVHEleaaKCLKEDMLNDSNTQIEQLRKmmlSHEGVLQEIRSILVDFE 197
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2204 E-----------LGKLKARIEAENRALILRDKDNTQRFL-------EEEAEKMKQVAEEAARLsVAAQEAARLRQLAEED 2265
Cdd:pfam15921  198 EasgkkiyehdsMSTIHFRSLGSAISKILRELDTEISYLkgrifpvEDQLEALKSESQNKIEL-LLQQHQDRIEQLISEH 276
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2266 LAQQRALAEKmlkekmqavqeATRLKAEAELLQQQKELAQEQARrlQEDKEQMAQ-QLVEETQGFQRTLEAERQRQLEMS 2344
Cdd:pfam15921  277 EVEITGLTEK-----------ASSARSQANSIQSQLEIIQEQAR--NQNSMYMRQlSDLESTVSQLRSELREAKRMYEDK 343
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2345 AEAERLKLRMAEMSRAQARAEEDaqRFRKQAEEIGEKLHR--TELATQEKvtlvqTLEIQRQQSDHDAERLRE---AIAE 2419
Cdd:pfam15921  344 IEELEKQLVLANSELTEARTERD--QFSQESGNLDDQLQKllADLHKREK-----ELSLEKEQNKRLWDRDTGnsiTIDH 416
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2420 LEREKEKLKQEAKLLQLKSEEMQTVQQEQILQETQALQ-KSFLSEKDSLLQRErfIEQEKAKLEQLFQDEVAKaKQLREE 2498
Cdd:pfam15921  417 LRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAIQgKNESLEKVSSLTAQ--LESTKEMLRKVVEELTAK-KMTLES 493
                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 254675251  2499 QQRQQQQMEQEKQELMASMEEARRRQREAEEGVRRKQEELQ 2539
Cdd:pfam15921  494 SERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQ 534
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
2124-2397 8.21e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 41.82  E-value: 8.21e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2124 QKQAADAEMEKHKKFAEQTLRQKAQVEQELTTLR----LQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVR 2199
Cdd:pfam13868   53 RERALEEEEEKEEERKEERKQYRQELEEQIEEREqkrqEEYEEKLQEREQMDEIVERIQEEDQAEAEEKLEKQRQLREEI 132
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2200 VQMEELGKL-----KARIEAENRALILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEE--DLAQQRAL 2272
Cdd:pfam13868  133 DEFNEEQAKwkeleKEEEKEEDLRILEYLKEKAEREEEREAERREIKEEKEREIARLRAQQEKAQDEKAErdELRAKLYQ 212
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2273 AEKMLKEKMQAVQEA-TRLKAEAELLQQQKELAQEQARRLQE--DKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAER 2349
Cdd:pfam13868  213 EEQERKWRQKEREEAeKKARQRQELQQAREEQIELKERRLAEeaEREEEEFERMLRKQAEDEEIEQEEAEKRREKRLEHR 292
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*...
gi 254675251  2350 LKLRMAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKVTLVQ 2397
Cdd:pfam13868  293 RELEKQIEERERQRAAEREEELEEGERLREEEAERRERIEEERQKKLK 340
HlyD pfam00529
HlyD membrane-fusion protein of T1SS; HlyD is a component of the prototypical alpha-haemolysin ...
1391-1570 8.33e-03

HlyD membrane-fusion protein of T1SS; HlyD is a component of the prototypical alpha-haemolysin (HlyA) bacterial type I secretion system, along with the other components HlyB and TolC. HlyD and HlyB are inner-membrane proteins and specific components of the transport apparatus of alpha-haemolysin. HlyD is anchored in the cytoplasmic membrane by a single transmembrane domain and has a large periplasmic domain within the carboxy-terminal 100 amino acids, HlyB and HlyD form a stable complex that binds the recombinant protein bearing a C-terminal HlyA signal sequence and ATP in the cytoplasm. HlyD, HlyB and TolC combine to form the three-component ABC transporter complex that forms a trans-membrane channel or pore through which HlyA can be transferred directly to the extracellular medium. Cutinase has been shown to be transported effectively through this pore.


Pssm-ID: 425733 [Multi-domain]  Cd Length: 322  Bit Score: 41.64  E-value: 8.33e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1391 RQSSEAEIQAKAQQVEA-AERSRMRIE-EEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERlRRQV 1468
Cdd:pfam00529   54 TDYQAALDSAEAQLAKAqAQVARLQAElDRLQALESELAISRQDYDGATAQLRAAQAAVKAAQAQLAQAQIDLAR-RRVL 132
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1469 QDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQAEEAERRLRQAEAERARQVQVALETAQRSAEVELQSK-- 1546
Cdd:pfam00529  133 APIGGISRESLVTAGALVAQAQANLLATVAQLDQIYVQITQSAAENQAEVRSELSGAQLQIAEAEAELKLAKLDLERTei 212
                          170       180
                   ....*....|....*....|....
gi 254675251  1547 RASFAEKTAQLERTLQEEHVTVAQ 1570
Cdd:pfam00529  213 RAPVDGTVAFLSVTVDGGTVSAGL 236
TPH pfam13868
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ...
1309-1707 8.35e-03

Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.


Pssm-ID: 433539 [Multi-domain]  Cd Length: 341  Bit Score: 41.82  E-value: 8.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1309 MEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAELE-AQELQRRMQEEVARREEAAVDAQQQKRSIQEEL 1387
Cdd:pfam13868   28 IEEKKRIKAEEKEEERRLDEMMEEERERALEEEEEKEEERKEERKQyRQELEEQIEEREQKRQEEYEEKLQEREQMDEIV 107
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1388 QHLRQSSEAEIQAKAQQVEAAERSRMRIEEEIRVVRlqletterqrggaegelQALRARAEEAEAQKRQAQEEAERLRRQ 1467
Cdd:pfam13868  108 ERIQEEDQAEAEEKLEKQRQLREEIDEFNEEQAKWK-----------------ELEKEEEKEEDLRILEYLKEKAEREEE 170
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1468 VQDESQRKRQAEAELALRVKAEAEAAREKQRALQALDELRLQaEEAERRLRQAEAERArqvqvaletaqrsaevelqskr 1547
Cdd:pfam13868  171 REAERREIKEEKEREIARLRAQQEKAQDEKAERDELRAKLYQ-EEQERKWRQKEREEA---------------------- 227
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1548 asfaEKTAQLERTLQEEHvtvaqlreeaerraqqqaeaerareeaerelerwqlKANEALRLRLQAEEVAQQKSLAQADA 1627
Cdd:pfam13868  228 ----EKKARQRQELQQAR------------------------------------EEQIELKERRLAEEAEREEEEFERML 267
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1628 EKQKEEAEREARRRGKAEEQAVR-QRELAEQELEKQRqlaegtaQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQH 1706
Cdd:pfam13868  268 RKQAEDEEIEQEEAEKRREKRLEhRRELEKQIEERER-------QRAAEREEELEEGERLREEEAERRERIEEERQKKLK 340

                   .
gi 254675251  1707 E 1707
Cdd:pfam13868  341 E 341
COG4913 COG4913
Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown];
1113-1393 8.37e-03

Uncharacterized protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 227250 [Multi-domain]  Cd Length: 1104  Bit Score: 42.32  E-value: 8.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1113 TLRDELRGAQEVGERLQQRHG-ERDVEVERWRERVTQLLERWQAVLAQTDVRQRELEQLGRQL-------RYYRESADPL 1184
Cdd:COG4913   591 TTRWEKDDRRKLGDRSTYRLGsTNDAKVETLRETVKAMLSREDFYMIKIMRQQGEYIKLQEQAnalahiqALNFASIDLP 670
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1185 SAWLQDA--KRRQEQIQAVPIAnCQAAREQLRQEKALLEEIER-HGEKVEEC------QKFAKQYINAIKDYELQLITYK 1255
Cdd:COG4913   671 SAQRQIAelQARLERLTHTQSD-IAIAKAALDAAQTRQKVLERqYQQEVTECaglkkdLKRAAMLSRKVHSIAKQGMTGA 749
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1256 AQLEPVAS-PAKKPKVQSGS--ESVIQEYVDLRTRYSElttltsqyikfISETLRRMEEE-----ERLAEQQRAEERERL 1327
Cdd:COG4913   750 LQALGAAHfPQVAPEQHDDIvdIERIEHRRQLQKRIDA-----------VNARLRRLREEiigrmSDAKKEDTAALSEVG 818
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 254675251 1328 AEVEAALEKQRQLAEAHAQAKAQAELEAQELQRRMQEevarREEAAVDAQ--QQKRSIQEELQHLRQS 1393
Cdd:COG4913   819 AELDDIPEYLARLQTLTEDALPEFLARFQELLNRSSD----DGVTQLLSHldHERALIEERIEAINDS 882
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
2146-2523 8.40e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 429718 [Multi-domain]  Cd Length: 488  Bit Score: 42.18  E-value: 8.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2146 KAQVEQELTTLRLQLEETDHQKSILDEELQRLKAEVteaarqrSQVEEELFSVRVQMEELGKLKARIEAENRALILRDKD 2225
Cdd:pfam07888   54 NRQREKEKERYKRDREQWERQRRELESRVAELKEEL-------RQSREKVEELEEKYKELSRSGEELAEEKDALLAQRAE 126
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2226 NTQRFLEEE---AEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMLkekmQAVQEATRLKAEAELLQQQKE 2302
Cdd:pfam07888  127 SEARIRELEediKTLTQRVLERETELERMKERVKKAGAQRKEEEAERKQLQAKLQ----QTEEELRSLSKEFQELRNSLA 202
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2303 LAQEQARRLQEDKEQMAQQLveeTQGFQRTLEAER--------QRQLEMSAE-AERLKLRMAEMSRAQARAEEDAQRFRK 2373
Cdd:pfam07888  203 QRDTQVLQLQDTITTLTQKL---TTAHRKEAENEAlleelrslQERLNASERkVEGLGEELSSMAAQRDRTQAELHQARL 279
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2374 QAEEIGEKLHRTELATQE-KVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAkllqlkseemqtvqqeqilQE 2452
Cdd:pfam07888  280 QAAQLTLQLADASLALREgRARWAQERETLQQSAEADKDRIEKLSAELQRLEERLQEER-------------------ME 340
                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 254675251  2453 TQALQKSFLSEKDS----LLQRERFIEQEKAKLeQLFQDEvakakqlreeqqrqQQQMEQEKQELMASMEEARRR 2523
Cdd:pfam07888  341 REKLEVELGREKDCnrvqLSESRRELQELKASL-RVAQKE--------------KEQLQAEKQELLEYIRQLEQR 400
CCCAP pfam15964
Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in ...
2144-2470 8.53e-03

Centrosomal colon cancer autoantigen protein family; CCCAP is a family of proteins found in eukaryotes. CCCAP is also known as SDCCAG8, serologically defined colon cancer antigen 8. It is associated with the centrosome.


Pssm-ID: 435040 [Multi-domain]  Cd Length: 703  Bit Score: 42.20  E-value: 8.53e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2144 RQKAQVEQELTTLRLQ-LEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVrVQMEE---LGKLKARIEAEN-RA 2218
Cdd:pfam15964  285 QHEAVLAQTHTNVHMQtIERLTKERDDLMSALVSVRSSLAEAQQRESSAYEQVKQA-VQMTEeanFEKTKALIQCEQlKS 363
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2219 LILRDKDNTQRFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLA-EEDLAQQRALAEKMLKEKMQAVQEATrlKAEAELL 2297
Cdd:pfam15964  364 ELERQKERLEKELASQQEKRAQEKEALRKEMKKEREELGATMLAlSQNVAQLEAQVEKVTREKNSLVSQLE--EAQKQLA 441
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2298 QQQKELAQEQAR-RLQEDKEQMAQqlvEETQGFQRTLEAERQRQLEMS-AEAERLKL-------RMAEMSRAQARAEEDA 2368
Cdd:pfam15964  442 SQEMDVTKVCGEmRYQLNQTKMKK---DEAEKEHREYRTKTGRQLEIKdQEIEKLGLelseskqRLEQAQQDAARAREEC 518
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2369 QRFrkqAEEIGEKLHRTELATQEKVTLVQ--------------------TLEIQRQQSDHDaERLREAIAELEREK---E 2425
Cdd:pfam15964  519 LKL---TELLGESEHQLHLTRLEKESIQQsfsneakaqalqaqqreqelTQKMQQMEAQHD-KTVNEQYSLLTSQNtfiA 594
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*
gi 254675251  2426 KLKQEAKLLQLKSEEMQTVQQEQILQETQalQKSFLSEKDSLLQR 2470
Cdd:pfam15964  595 KLKEECCTLAKKLEEITQKSRSEVEQLSQ--EKEYLQDRLEKLQK 637
MAD pfam05557
Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint ...
1050-1518 8.84e-03

Mitotic checkpoint protein; This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated.


Pssm-ID: 428520 [Multi-domain]  Cd Length: 660  Bit Score: 42.02  E-value: 8.84e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1050 LEKLKTISLVIRSTQGAEEVLKTHEEQLKEAQAVPATLQELEATKASLkklraQAEAQQpVFNTLRDELRGAQEVGERLQ 1129
Cdd:pfam05557   51 QELQKRIRLLEKREAEAEEALREQAELNRLKKKNLEALNKKLNEKESQ-----LADARE-VISCLKNELSELRRQIQRQE 124
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1130 QRHGERDVEVERWRERVTQLLERWQAV---LAQTDVRQREL---EQLGRQLRYYRESADPLSAWLQDAKRRQEQiqavpI 1203
Cdd:pfam05557  125 LELSSTNSELEELQERLDLQKAKAQEAeqlRQNLEAQQSSLaeaEQRIKELEFEIQSQEQDSEIVKNSKSELAR-----I 199
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1204 ANCQAAREQLRQEKALLEEIERHGEKVEECQKFAKQYINAIKDYELQLITYKAQLEPVASPAKK-PKVQSGSESVIQEYV 1282
Cdd:pfam05557  200 PELERELERLREHNKHLNENIENKLLLKEEVEDLKRKLEREEGYREELATLELEKEKLEQELKSwEKLAQDTGLNLRSPE 279
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1283 DLRTRYSEL-----------TTLTSQyIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEK-QRQL---------- 1340
Cdd:pfam05557  280 DLSRRIEQLqqreitlkeenSSLTSS-ARQLEKAQRELEQELAQYLKNIEDLNKKLKRHKALVRRlQRRVllltkerdgm 358
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1341 ------------AEAHAQAKAQAELEAQELQRRMQ---EEVARR----EEAAVDAQQQKRSIQEELQHLRQ--------S 1393
Cdd:pfam05557  359 railesydkeltPSNYSPQLLERIEEAEDMTQDMQahnEEMEAQlsvaEEELGGYKQQATTLERELQALRQqesladpsY 438
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  1394 SEAEIQAKAQQVEAAERSRMRIEEEIRVVRLQLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQ--DE 1471
Cdd:pfam05557  439 SKEEVDSLRRKLETLEAERQRLREQKNELEMELERRCLQGDYDPKKTKVLHLSMNPAAEAYQQRANDLEKLQAEIErlKR 518
                          490       500       510       520
                   ....*....|....*....|....*....|....*....|....*..
gi 254675251  1472 SQRKRQAEAELALRVKAEAEAAREKQralqaLDELRLQAEEAERRLR 1518
Cdd:pfam05557  519 RLKKLEDDLEQVGSLPETTSTMNFKE-----VLELRKELESAELKNQ 560
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
2122-2586 8.88e-03

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 42.12  E-value: 8.88e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2122 LKQKQAADAEMEKHKKFAEQTLRQKAQVEQELTtlrlQLEETDHQKSILDEELQRLKAEVTEAARQRSQVE-----EELF 2196
Cdd:pfam10174   58 LKEQYRVTQEENQHLQLTIQALQDELRAQRDLN----QLLQQDFTTSPVDGEDKFSTPELTEENFRRLQSEherqaKELF 133
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2197 SVRVQMEELgklKARIEAENRALILRDkDNTQRFLE---EEAEKMKQVAEEAARLSVAAQEAARLRQLaeEDLAQQRALA 2273
Cdd:pfam10174  134 LLRKTLEEM---ELRIETQKQTLGARD-ESIKKLLEmlqSKGLPKKSGEEDWERTRRIAEAEMQLGHL--EVLLDQKEKE 207
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2274 EKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLqedkEQMAQQLVEETQGFQRTLEaerqrqLEMSAEAERLKlr 2353
Cdd:pfam10174  208 NIHLREELHRRNQLQPDPAKTKALQTVIEMKDTKISSL----ERNIRDLEDEVQMLKTNGL------LHTEDREEEIK-- 275
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2354 maemsraQARAEEDAQRFRK-QAEEIGEKLHRTELATQEKVTLVQTLEIQRQQSDHDAERLREAIAELEREKEKLKQEAK 2432
Cdd:pfam10174  276 -------QMEVYKSHSKFMKnKIDQLKQELSKKESELLALQTKLETLTNQNSDCKQHIEVLKESLTAKEQRAAILQTEVD 348
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2433 LLQLKSEEMQTV-----QQEQILQETQALQKSFLSE-KDSLLQRERFIEQEKAKLEQLFQDEVAKAKQLREEQQRQQQQM 2506
Cdd:pfam10174  349 ALRLRLEEKESFlnkktKQLQDLTEEKSTLAGEIRDlKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQ 428
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251  2507 EQEKQE--LMASMEEArrrQREAEEGVRRKQEELQHLEQQRQQQEKLLAEENQRLRERLQRLE----EEHRAALAHSEIA 2580
Cdd:pfam10174  429 TDSSNTdtALTTLEEA---LSEKERIIERLKEQREREDRERLEELESLKKENKDLKEKVSALQpeltEKESSLIDLKEHA 505

                   ....*.
gi 254675251  2581 TTQAAS 2586
Cdd:pfam10174  506 SSLASS 511
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
1644-1744 9.16e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 42.25  E-value: 9.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1644 AEEQAVRQRELAEQELEKQRQLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQHEATAATQKRQELEAELA 1723
Cdd:PRK11448  143 LLHALQQEVLTLKQQLELQAREKAQSQALAEAQQQELVALEGLAAELEEKQQELEAQLEQLQEKAAETSQERKQKRKEIT 222
                          90       100
                  ....*....|....*....|.
gi 254675251 1724 KvRAEMEVLLaskarAEEESR 1744
Cdd:PRK11448  223 D-QAAKRLEL-----SEEETR 237
hsdR PRK11448
type I restriction enzyme EcoKI subunit R; Provisional
1374-1520 9.24e-03

type I restriction enzyme EcoKI subunit R; Provisional


Pssm-ID: 236912 [Multi-domain]  Cd Length: 1123  Bit Score: 42.25  E-value: 9.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1374 VDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERsrmrieeeirvvrlqletterqrggAEGELQALRARAEEAEAQ 1453
Cdd:PRK11448  138 EDPENLLHALQQEVLTLKQQLELQAREKAQSQALAEA-------------------------QQQELVALEGLAAELEEK 192
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 254675251 1454 KRQAQEEAERLRRQVQdesqrkrQAEAElalrvkaeaEAAREKQRALQALDELRLqaEEAERR------LRQA 1520
Cdd:PRK11448  193 QQELEAQLEQLQEKAA-------ETSQE---------RKQKRKEITDQAAKRLEL--SEEETRilidqqLRKA 247
PRK11281 PRK11281
mechanosensitive channel MscK;
1146-1423 9.25e-03

mechanosensitive channel MscK;


Pssm-ID: 236892 [Multi-domain]  Cd Length: 1113  Bit Score: 42.21  E-value: 9.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1146 VTQLLERWQAVLAQTDVRQRELEQLGRQLryyrESADplsAWLQDAkrrQEQIQAVPIANCQAAREQLrqEKALLEEIER 1225
Cdd:PRK11281   61 VQQDLEQTLALLDKIDRQKEETEQLKQQL----AQAP---AKLRQA---QAELEALKDDNDEETRETL--STLSLRQLES 128
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1226 hgeKVEECQKFAKQYINAIKDYELQLITYKAQLEpvaspakkpKVQSGSESVIQEYVDLRTRYSelTTLTSQyiKFISET 1305
Cdd:PRK11281  129 ---RLAQTLDQLQNAQNDLAEYNSQLVSLQTQPE---------RAQAALYANSQRLQQIRNLLK--GGKVGG--KALRPS 192
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1306 LR-RMEEEERLAEQQRAEERERLA---EVEAALEKQRQLAEAHAQakaQAELEAQELQ------RRMQ-EEVARREEAAV 1374
Cdd:PRK11281  193 QRvLLQAEQALLNAQNDLQRKSLEgntQLQDLLQKQRDYLTARIQ---RLEHQLQLLQeainskRLTLsEKTVQEAQSQD 269
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 254675251 1375 DAQQQKRS--IQEELQHLRQSSEAEIQAKA-------------QQVEAAERSRMRIEEEIRVVR 1423
Cdd:PRK11281  270 EAARIQANplVAQELEINLQLSQRLLKATEklntltqqnlrvkNWLDRLTQSERNIKEQISVLK 333
PRK12705 PRK12705
hypothetical protein; Provisional
1749-1897 9.51e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 42.00  E-value: 9.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1749 KSKQRLEAEAGRFRELA-EEAARLRALAEEAKRQRQLAEEDAARQRAEAERV-----------LTEKLAAisEATRLKTE 1816
Cdd:PRK12705   26 KKRQRLAKEAERILQEAqKEAEEKLEAALLEAKELLLRERNQQRQEARREREelqreeerlvqKEEQLDA--RAEKLDNL 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1817 AEIALKEKEAENERLRRLAEDEAFQRRRLEEQAALHKadiEERLAQLRKASESELERQKGLVEDTLRQRRQVEEEIMALK 1896
Cdd:PRK12705  104 ENQLEEREKALSARELELEELEKQLDNELYRVAGLTP---EQARKLLLKLLDAELEEEKAQRVKKIEEEADLEAERKAQN 180

                  .
gi 254675251 1897 V 1897
Cdd:PRK12705  181 I 181
PRK12472 PRK12472
hypothetical protein; Provisional
1432-1570 9.59e-03

hypothetical protein; Provisional


Pssm-ID: 237110 [Multi-domain]  Cd Length: 508  Bit Score: 41.78  E-value: 9.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1432 QRGGAEGElQALRArAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAEAELALRVKAEAEAAREKQRAlqaldelrlQAE 1511
Cdd:PRK12472  193 ETLAREAE-DAARA-ADEAKTAAAAAAREAAPLKASLRKLERAKARADAELKRADKALAAAKTDEAKA---------RAE 261
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 254675251 1512 EAERRLRQAEAERARQvqvaLETAQrsAEVELQSKRASFAEKTAQLERTLQEEHVTVAQ 1570
Cdd:PRK12472  262 ERQQKAAQQAAEAATQ----LDTAK--ADAEAKRAAAAATKEAAKAAAAKKAETAKAAT 314
PRK12705 PRK12705
hypothetical protein; Provisional
1334-1498 9.93e-03

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 42.00  E-value: 9.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1334 LEKQRQLAEAHAQAKAQAELEAQELQRRMQEEvaRREEAAVDAQQQKRSIQEELQHLRQSSEAEIQAKAQQVEAAERsrm 1413
Cdd:PRK12705   25 LKKRQRLAKEAERILQEAQKEAEEKLEAALLE--AKELLLRERNQQRQEARREREELQREEERLVQKEEQLDARAEK--- 99
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 1414 rieeeirvvrlqLETTERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDE---SQRKRQAEAELALRVKAEA 1490
Cdd:PRK12705  100 ------------LDNLENQLEEREKALSARELELEELEKQLDNELYRVAGLTPEQARKlllKLLDAELEEEKAQRVKKIE 167

                  ....*...
gi 254675251 1491 EAAREKQR 1498
Cdd:PRK12705  168 EEADLEAE 175
Tar COG0840
Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms];
2151-2484 9.96e-03

Methyl-accepting chemotaxis protein [Cell motility, Signal transduction mechanisms];


Pssm-ID: 223910 [Multi-domain]  Cd Length: 408  Bit Score: 41.90  E-value: 9.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2151 QELTTLRLQLEETDHQKSILDEELQRLKAEVTEAARQRSQVEEELFSVRVQMEEL--GKLKARIEAENRALILRDKDNTQ 2228
Cdd:COG0840    44 LDDAASAEAAALKAVLKFLLISLLVAIIVVLVLAILLLRAILEPISDLLEVVERIaaGDLTKRIDESSNDEFGQLAKSFN 123
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2229 RFLEEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLAQQRALAEKMlKEKMQAVQEATRLKAEAelLQQQKELAQEqA 2308
Cdd:COG0840   124 EMILNLRQIIDAVQDNAEALSGASEEIAASATELSARADQQAESLEEV-ASAIEELSETVKEVAFN--AKEAAALASE-A 199
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2309 RRLQEDKEQMAQQLVEETQGFQRTLEAERQRQLEMSAEAERLKLRMAEMSRA-----------QARAEEDAQRFRKQAEE 2377
Cdd:COG0840   200 SQVAEEGGEEVRQAVEQMQEIAEELAEVVKKLSESSQEIEEITSVINSIAEQtnllalnaaieAARAGEAGRGFAVVADE 279
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 254675251 2378 IGEKLHRTELATQEKVTLVQTLeiqRQQSDHDAERLREAIAELEREKEKLKQEAKLLQLKSEEMQTVQQ--EQILQETQA 2455
Cdd:COG0840   280 VRKLAERSADSAKEIGLLIEEI---QNEAADAVEHMEESASEVSEGVKLVEETGSSLGEIAAAIEEVSQliSEIAAATEE 356
                         330       340
                  ....*....|....*....|....*....
gi 254675251 2456 LQKSFLSEKDSLLQRERFIEQEKAKLEQL 2484
Cdd:COG0840   357 QTAVLEEINASIEELDDVTQENAAAVEEL 385
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.20
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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