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Conserved domains on  [gi|63003903|ref|NP_963844|]
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leucine-rich repeat-containing protein 10 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-223 5.43e-37

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.45  E-value: 5.43e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  50 SFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIE 129
Cdd:COG4886 111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903 130 ANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPtVLLHMPFLEVIDVDWNSIRYFPSLA 209
Cdd:COG4886 191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLA 269

                       170
                ....*....|....
gi 63003903 210 HLSSLKLVIYDHNP 223
Cdd:COG4886 270 NLTNLKTLDLSNNQ 283
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-223 5.43e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.45  E-value: 5.43e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  50 SFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIE 129
Cdd:COG4886 111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903 130 ANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPtVLLHMPFLEVIDVDWNSIRYFPSLA 209
Cdd:COG4886 191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLA 269

                       170
                ....*....|....
gi 63003903 210 HLSSLKLVIYDHNP 223
Cdd:COG4886 270 NLTNLKTLDLSNNQ 283
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-206 1.38e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.41  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   57 LYLSDNHLNSLPPELGQlqNLQILALDFNNFKALPQVVCTLKQLCILYlgNNKLCDLPSELSllQNLRTLWIEANCLT-- 134
Cdd:PRK15370 225 LYANSNQLTSIPATLPD--TIQEMELSINRITELPERLPSALQSLDLF--HNKISCLPENLP--EELRYLSVYDNSIRtl 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  135 --QLPDVVCELSL---------------LKTLHAGSNALRLLPGQLRrlQELRTIWLSGNRLTDFPTVLlhMPFLEVIDV 197
Cdd:PRK15370 299 paHLPSGITHLNVqsnsltalpetlppgLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETL--PPTITTLDV 374


                 ....*....
gi 63003903  198 DWNSIRYFP 206
Cdd:PRK15370 375 SRNALTNLP 383
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 36-197 1.90e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 1.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  36 LSGSQLRRFP-LHVCsfRELVKLYLSDNHLNSLPPeLGQLQNLQILALDFNNFKALPQVVCtLKQLCILYLGNNKLCDLp 114
Cdd:cd21340   9 LNDKNITKIDnLSLC--KNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVV- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903 115 SELSLLQNLRTLWIEA------NCLTQLPDVVCELSL-LKTLHAGSNALRLLpGQLRRLQELRTIWLSGNRLTDFP---T 184
Cdd:cd21340  84 EGLENLTNLEELHIENqrlppgEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEellD 162

                       170
                ....*....|...
gi 63003903 185 VLLHMPFLEVIDV 197
Cdd:cd21340 163 LLSSWPSLRELDL 175
LRR_8 pfam13855
Leucine rich repeat;
52-110 3.84e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 3.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 63003903    52 RELVKLYLSDNHLNSLPPE-LGQLQNLQILALDFNNFKALPQVVCT-LKQLCILYLGNNKL 110
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-223 5.43e-37

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 135.45  E-value: 5.43e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  50 SFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLLQNLRTLWIE 129
Cdd:COG4886 111 NLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLS 190

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903 130 ANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPtVLLHMPFLEVIDVDWNSIRYFPSLA 209
Cdd:COG4886 191 NNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPPLA 269

                       170
                ....*....|....
gi 63003903 210 HLSSLKLVIYDHNP 223
Cdd:COG4886 270 NLTNLKTLDLSNNQ 283
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
30-232 3.38e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 120.04  E-value: 3.38e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  30 LDKMVDLSGSQLRRFPLHVCSFRELVKLYLSDNhlnslpPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNK 109
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQ 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903 110 LCDLPSELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHM 189
Cdd:COG4886 148 LTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANL 227

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 63003903 190 PFLEVIDVDWNSIRYFPSLAHLSSLKLVIYDHNPCRNAPKVAK 232
Cdd:COG4886 228 TNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLAN 270
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-188 5.93e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 5.93e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  35 DLSGSQLRRFPLHVCSFRELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVvCTLKQLCILYLGNNKLCDLP 114
Cdd:COG4886 188 DLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL-GNLTNLEELDLSNNQLTDLP 266

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 63003903 115 SELSLlQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLH 188
Cdd:COG4886 267 PLANL-TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTT 339
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-229 4.80e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.28  E-value: 4.80e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  53 ELVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKlcdlpsELSLLQNLRTLWIEANC 132
Cdd:COG4886  51 LLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQ 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903 133 LTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFP-SLAHL 211
Cdd:COG4886 125 LTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPePLGNL 204

                       170
                ....*....|....*...
gi 63003903 212 SSLKLVIYDHNPCRNAPK 229
Cdd:COG4886 205 TNLEELDLSGNQLTDLPE 222
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
57-206 1.38e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 67.41  E-value: 1.38e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   57 LYLSDNHLNSLPPELGQlqNLQILALDFNNFKALPQVVCTLKQLCILYlgNNKLCDLPSELSllQNLRTLWIEANCLT-- 134
Cdd:PRK15370 225 LYANSNQLTSIPATLPD--TIQEMELSINRITELPERLPSALQSLDLF--HNKISCLPENLP--EELRYLSVYDNSIRtl 298

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  135 --QLPDVVCELSL---------------LKTLHAGSNALRLLPGQLRrlQELRTIWLSGNRLTDFPTVLlhMPFLEVIDV 197
Cdd:PRK15370 299 paHLPSGITHLNVqsnsltalpetlppgLKTLEAGENALTSLPASLP--PELQVLDVSKNQITVLPETL--PPTITTLDV 374


                 ....*....
gi 63003903  198 DWNSIRYFP 206
Cdd:PRK15370 375 SRNALTNLP 383
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 36-197 1.90e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 62.11  E-value: 1.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  36 LSGSQLRRFP-LHVCsfRELVKLYLSDNHLNSLPPeLGQLQNLQILALDFNNFKALPQVVCtLKQLCILYLGNNKLCDLp 114
Cdd:cd21340   9 LNDKNITKIDnLSLC--KNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIENLEN-LVNLKKLYLGGNRISVV- 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903 115 SELSLLQNLRTLWIEA------NCLTQLPDVVCELSL-LKTLHAGSNALRLLpGQLRRLQELRTIWLSGNRLTDFP---T 184
Cdd:cd21340  84 EGLENLTNLEELHIENqrlppgEKLTFDPRSLAALSNsLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEellD 162

                       170
                ....*....|...
gi 63003903 185 VLLHMPFLEVIDV 197
Cdd:cd21340 163 LLSSWPSLRELDL 175
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
29-223 2.31e-10

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 60.95  E-value: 2.31e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   29 PLDKMVDLSGSQLRRFP------LHVCSFRE-----------LVKLYLSDNHLNSLPPELGQLQNLQILALDFNNFKALP 91
Cdd:PRK15387 242 PELRTLEVSGNQLTSLPvlppglLELSIFSNplthlpalpsgLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALP 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   92 QvvctlkQLCILYLGNNKLCDLPSELSLLQNLRtlwIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRL----- 166
Cdd:PRK15387 322 S------ELCKLWAYNNQLTSLPTLPSGLQELS---VSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELivsgn 392

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 63003903  167 ---------QELRTIWLSGNRLTDFPTVLLHMPFLEVIDvdwNSIRYFP-SLAHLSSLKLVIYDHNP 223
Cdd:PRK15387 393 rltslpvlpSELKELMVSGNRLTSLPMLPSGLLSLSVYR---NQLTRLPeSLIHLSSETTVNLEGNP 456
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 32-202 1.06e-08

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 56.01  E-value: 1.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   32 KMVDLSGSQLR-RFPLHVCSFRELVKLYLSDNHL-NSLPPELGQLQNLQILALDFNNFKA-------------------- 89
Cdd:PLN00113 167 KVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLvGQIPRELGQMKSLKWIYLGYNNLSGeipyeiggltslnhldlvyn 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   90 -----LPQVVCTLKQLCILYLGNNKLCD-LPSELSLLQNLRTLWIEANCLT-QLPDVVCELSLLKTLHAGSNALR-LLPG 161
Cdd:PLN00113 247 nltgpIPSSLGNLKNLQYLFLYQNKLSGpIPPSIFSLQKLISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTgKIPV 326

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 63003903  162 QLRRLQELRTIWLSGNRLT-DFPTVLLHMPFLEVIDVDWNSI 202
Cdd:PLN00113 327 ALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNL 368
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
49-237 1.01e-06

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 49.78  E-value: 1.01e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   49 CSFRELVKLYLSDNHLNSLPPELGQLQNLQILAldfNNFKALPQVVCTLKQLCILylgNNKLCDLPselSLLQNLRTLWI 128
Cdd:PRK15387 219 CLPAHITTLVIPDNNLTSLPALPPELRTLEVSG---NQLTSLPVLPPGLLELSIF---SNPLTHLP---ALPSGLCKLWI 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  129 EANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLqelrtiWLSGNRLTDFPTVLLHMPFLEVIDVDWNSIRYFPSL 208
Cdd:PRK15387 290 FGNQLTSLPVLPPGLQELSVSDNQLASLPALPSELCKL------WAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSE 363

                        170       180
                 ....*....|....*....|....*....
gi 63003903  209 AHlsslKLVIYDhNPCRNAPKVAKGVRRV 237
Cdd:PRK15387 364 LY----KLWAYN-NRLTSLPALPSGLKEL 387
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
80-228 1.12e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.70  E-value: 1.12e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   80 LALDFNNFKALPQVVCtlKQLCILYLGNNKLCDLPSELSllQNLRTLWIEANCLTQ----LPDVVCELSL---------- 145
Cdd:PRK15370 183 LRLKILGLTTIPACIP--EQITTLILDNNELKSLPENLQ--GNIKTLYANSNQLTSipatLPDTIQEMELsinritelpe 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  146 -----LKTLHAGSNALRLLPGQLRrlQELRTIWLSGNRLTDFPTvllHMPF-LEVIDVDWNSIRYFPSLAHLsSLKLVIY 219
Cdd:PRK15370 259 rlpsaLQSLDLFHNKISCLPENLP--EELRYLSVYDNSIRTLPA---HLPSgITHLNVQSNSLTALPETLPP-GLKTLEA 332


                 ....*....
gi 63003903  220 DHNPCRNAP 228
Cdd:PRK15370 333 GENALTSLP 341
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 24-200 7.97e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.50  E-value: 7.97e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  24 DLREMPLDKM-VDLSGSQLRRFPLHVCsfrelvKLYLSDNHLNSlppelgqlQNLQILALDFnnfkalpQVVCTLKqlcI 102
Cdd:cd00116 114 KLNNNGLGDRgLRLLAKGLKDLPPALE------KLVLGRNRLEG--------ASCEALAKAL-------RANRDLK---E 169

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903 103 LYLGNNKLCD-----LPSELSLLQNLRTLWIEANCLT-----QLPDVVCELSLLKTLHAGSNALR------LLPGQLRRL 166
Cdd:cd00116 170 LNLANNGIGDagiraLAEGLKANCNLEVLDLNNNGLTdegasALAETLASLKSLEVLNLGDNNLTdagaaaLASALLSPN 249

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 63003903 167 QELRTIWLSGNRLTD-----FPTVLLHMPFLEVIDVDWN 200
Cdd:cd00116 250 ISLLTLSLSCNDITDdgakdLAEVLAEKESLLELDLRGN 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
35-187 9.81e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 9.81e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  35 DLSGSQLRRFPlHVCSFRELVKLYLSDNHLNSLPPeLGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLP 114
Cdd:COG4886 234 DLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 63003903 115 SELSLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLTDFPTVLL 187
Cdd:COG4886 312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
3-172 2.33e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.46  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903    3 NTIRALVAfIPADRCQ----NYVVRDLREMPLD-KMVDLSGSQLRRFPLHVcsfRELVKLYLSDNHLNSLPPELGQLQNL 77
Cdd:PRK15387 312 NQLASLPA-LPSELCKlwayNNQLTSLPTLPSGlQELSVSDNQLASLPTLP---SELYKLWAYNNRLTSLPALPSGLKEL 387

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   78 QILAldfNNFKALPQVVCTLKQLCIlylGNNKLCDLPSelsLLQNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNalr 157
Cdd:PRK15387 388 IVSG---NRLTSLPVLPSELKELMV---SGNRLTSLPM---LPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGN--- 455

                        170
                 ....*....|....*
gi 63003903  158 llPGQLRRLQELRTI 172
Cdd:PRK15387 456 --PLSERTLQALREI 468
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 25-217 2.70e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.57  E-value: 2.70e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  25 LREMPLDKMVDLSGSQLRRFP--LHVC-----SFRELVKLYLSDNHLNSLPPE----LGQLQNLQILALDFNNF--KALP 91
Cdd:cd00116  47 LRPQPSLKELCLSLNETGRIPrgLQSLlqgltKGCGLQELDLSDNALGPDGCGvlesLLRSSSLQELKLNNNGLgdRGLR 126

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  92 QVVCTLKQ----LCILYLGNNKLcdlpselsllqnlrtlwiEANCLTQLPDVVCELSLLKTLHAGSNALR------LLPG 161
Cdd:cd00116 127 LLAKGLKDlppaLEKLVLGRNRL------------------EGASCEALAKALRANRDLKELNLANNGIGdagiraLAEG 188

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 63003903 162 qLRRLQELRTIWLSGNRLTD-----FPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLKLV 217
Cdd:cd00116 189 -LKANCNLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAGAAALASALLSP 248
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-156 3.50e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   43 RFPLHVCSFRELVKLYLSDNHLN-SLPPELGQLQNLQILALDFNNFKA-LPQVVCTLKQLCILYLGNNKLCD-LPSELSL 119
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEGeIPKSLGA 402

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 63003903  120 LQNLRTLWIEANCLT-QLPDVVCELSLLKTLHAGSNAL 156
Cdd:PLN00113 403 CRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNL 440
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 33-180 3.50e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 3.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   33 MVDLSGSQLR-RFPLHVCSFRELVKLYLSDNHLNS-LPPELGQLQNLQILALDFNNFKA-LPQVVCTLKQLCILYLGNNK 109
Cdd:PLN00113 360 VLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGeIPKSLGACRSLRRVRLQDNSFSGeLPSEFTKLPLVYFLDISNNN 439

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903  110 LC--------DLPS--ELSLLQNlrtlwieaNCLTQLPDVVCElSLLKTLHAGSNALR-LLPGQLRRLQELRTIWLSGNR 178
Cdd:PLN00113 440 LQgrinsrkwDMPSlqMLSLARN--------KFFGGLPDSFGS-KRLENLDLSRNQFSgAVPRKLGSLSELMQLKLSENK 510


                 ..
gi 63003903  179 LT 180
Cdd:PLN00113 511 LS 512
LRR_8 pfam13855
Leucine rich repeat;
52-110 3.84e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 3.84e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 63003903    52 RELVKLYLSDNHLNSLPPE-LGQLQNLQILALDFNNFKALPQVVCT-LKQLCILYLGNNKL 110
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLSPGAFSgLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 34-117 1.50e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 39.80  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   34 VDLSGSQLRRF-PLHVCSFRELVKLYLSDNHLN-SLPPELGQLQNLQILALDFNNFK-ALPQVVCTLKQLCILYLGNNKL 110
Cdd:PLN03150 423 LGLDNQGLRGFiPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLNGNSL 502


                 ....*...
gi 63003903  111 C-DLPSEL 117
Cdd:PLN03150 503 SgRVPAAL 510
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 45-201 5.84e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 37.91  E-value: 5.84e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   45 PLHVCSFRELVKLYLSDNHLNSLPPEL-GQLQNL------------------------QILALDFNNFKA-LPQVVCTLK 98
Cdd:PLN00113 277 PPSIFSLQKLISLDLSDNSLSGEIPELvIQLQNLeilhlfsnnftgkipvaltslprlQVLQLWSNKFSGeIPKNLGKHN 356

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 63003903   99 QLCILYLGNNKLC-DLPSELSLLQNLRTLWIEANCL-TQLPDVVCELSLLKTLHAGSNALR-LLPGQLRRLQELRTIWLS 175
Cdd:PLN00113 357 NLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDIS 436

                        170       180
                 ....*....|....*....|....*..
gi 63003903  176 GNRLT-DFPTVLLHMPFLEVIDVDWNS 201
Cdd:PLN00113 437 NNNLQgRINSRKWDMPSLQMLSLARNK 463
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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