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Conserved domains on  [gi|45387639|ref|NP_991169|]
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transcriptional adapter 1 [Danio rerio]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HFD_TADA1 cd22934
histone-fold domain found in transcriptional adapter 1 (TADA1) and similar proteins; TADA1, ...
 145-228 4.35e-34

histone-fold domain found in transcriptional adapter 1 (TADA1) and similar proteins; TADA1, also called SPT3-associated factor 42, or STAF42, or transcriptional adapter 1-like protein (TADA1L), may be involved in transcriptional regulation. It functions as a component of the STAGA transcription coactivator-HAT complex, which is composed at least of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.


:

Pssm-ID: 467058  Cd Length: 84  Bit Score: 119.97  E-value: 4.35e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387639 145 LPSRGQLEARMMVSAFESDLDSVAEDAVSCMLCALQVHLKDILTALVSRRKAYRLRDGHFLYAFGSDVtPRPYLKNSLPA 224
Cdd:cd22934   1 LPDIAMLHGRMLVTAWECGLDGVTDNAVELVVQAVENFLKNIITAVISRRKGYRLRDGKFKYSMGVPV-PNPYLRNSSSL 79


                ....
gi 45387639 225 YHSA 228
Cdd:cd22934  80 QDEA 83
SAGA-Tad1 super family cl15080
Transcriptional regulator of RNA polII, SAGA, subunit; The yeast SAGA complex is a ...
 7-193 1.02e-14

Transcriptional regulator of RNA polII, SAGA, subunit; The yeast SAGA complex is a multifunctional coactivator that regulates transcription by RNA polymerase II. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA. The complex can also be conceived of as consisting of two histone-fold-containing core subunits, and this family is one of these. As a family it is likely to carry binding regions for interactions with a number of the other components of the complex.


The actual alignment was detected with superfamily member pfam12767:

Pssm-ID: 463692  Cd Length: 135  Bit Score: 69.81  E-value: 1.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387639     7 ELEIAKKNLTDAIG-ENVKHYWANLKLWFKQKISKEEFDLEARRLLAQDNVHVHNDFLLAILTRCQIIVStsegpgslqw 85
Cdd:pfam12767   3 DLEELKTQLKKKLGpERWEKYFEALSRFLSGKLSKAELDKLCDPILGRENLHLHNQLILSILANAQEIRS---------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387639    86 sggsaskpgkpsrgkkkfpsvrqkfdhRFQPqnPLAgvpvfspreaeeeelklsAQTLLLPSRGQLEARMMVSAFESDLD 165
Cdd:pfam12767  73 ---------------------------PYAA--PLA------------------YESGELPDTDSLRKRMEPIAYEHGLV 105

                         170       180
                  ....*....|....*....|....*....
gi 45387639   166 S-VAEDAVSCMLCALQVHLKDILTALVSR 193
Cdd:pfam12767 106 GgVSADCANLLNNALDVYLKNLLESCIDL 134
 
Name Accession Description Interval E-value
HFD_TADA1 cd22934
histone-fold domain found in transcriptional adapter 1 (TADA1) and similar proteins; TADA1, ...
 145-228 4.35e-34

histone-fold domain found in transcriptional adapter 1 (TADA1) and similar proteins; TADA1, also called SPT3-associated factor 42, or STAF42, or transcriptional adapter 1-like protein (TADA1L), may be involved in transcriptional regulation. It functions as a component of the STAGA transcription coactivator-HAT complex, which is composed at least of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.


Pssm-ID: 467058  Cd Length: 84  Bit Score: 119.97  E-value: 4.35e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387639 145 LPSRGQLEARMMVSAFESDLDSVAEDAVSCMLCALQVHLKDILTALVSRRKAYRLRDGHFLYAFGSDVtPRPYLKNSLPA 224
Cdd:cd22934   1 LPDIAMLHGRMLVTAWECGLDGVTDNAVELVVQAVENFLKNIITAVISRRKGYRLRDGKFKYSMGVPV-PNPYLRNSSSL 79


                ....
gi 45387639 225 YHSA 228
Cdd:cd22934  80 QDEA 83
SAGA-Tad1 pfam12767
Transcriptional regulator of RNA polII, SAGA, subunit; The yeast SAGA complex is a ...
 7-193 1.02e-14

Transcriptional regulator of RNA polII, SAGA, subunit; The yeast SAGA complex is a multifunctional coactivator that regulates transcription by RNA polymerase II. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA. The complex can also be conceived of as consisting of two histone-fold-containing core subunits, and this family is one of these. As a family it is likely to carry binding regions for interactions with a number of the other components of the complex.


Pssm-ID: 463692  Cd Length: 135  Bit Score: 69.81  E-value: 1.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387639     7 ELEIAKKNLTDAIG-ENVKHYWANLKLWFKQKISKEEFDLEARRLLAQDNVHVHNDFLLAILTRCQIIVStsegpgslqw 85
Cdd:pfam12767   3 DLEELKTQLKKKLGpERWEKYFEALSRFLSGKLSKAELDKLCDPILGRENLHLHNQLILSILANAQEIRS---------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387639    86 sggsaskpgkpsrgkkkfpsvrqkfdhRFQPqnPLAgvpvfspreaeeeelklsAQTLLLPSRGQLEARMMVSAFESDLD 165
Cdd:pfam12767  73 ---------------------------PYAA--PLA------------------YESGELPDTDSLRKRMEPIAYEHGLV 105

                         170       180
                  ....*....|....*....|....*....
gi 45387639   166 S-VAEDAVSCMLCALQVHLKDILTALVSR 193
Cdd:pfam12767 106 GgVSADCANLLNNALDVYLKNLLESCIDL 134
 
Name Accession Description Interval E-value
HFD_TADA1 cd22934
histone-fold domain found in transcriptional adapter 1 (TADA1) and similar proteins; TADA1, ...
 145-228 4.35e-34

histone-fold domain found in transcriptional adapter 1 (TADA1) and similar proteins; TADA1, also called SPT3-associated factor 42, or STAF42, or transcriptional adapter 1-like protein (TADA1L), may be involved in transcriptional regulation. It functions as a component of the STAGA transcription coactivator-HAT complex, which is composed at least of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.


Pssm-ID: 467058  Cd Length: 84  Bit Score: 119.97  E-value: 4.35e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387639 145 LPSRGQLEARMMVSAFESDLDSVAEDAVSCMLCALQVHLKDILTALVSRRKAYRLRDGHFLYAFGSDVtPRPYLKNSLPA 224
Cdd:cd22934   1 LPDIAMLHGRMLVTAWECGLDGVTDNAVELVVQAVENFLKNIITAVISRRKGYRLRDGKFKYSMGVPV-PNPYLRNSSSL 79


                ....
gi 45387639 225 YHSA 228
Cdd:cd22934  80 QDEA 83
SAGA-Tad1 pfam12767
Transcriptional regulator of RNA polII, SAGA, subunit; The yeast SAGA complex is a ...
 7-193 1.02e-14

Transcriptional regulator of RNA polII, SAGA, subunit; The yeast SAGA complex is a multifunctional coactivator that regulates transcription by RNA polymerase II. It is formed of five major modular subunits and shows a high degree of structural conservation to human TFTC and STAGA. The complex can also be conceived of as consisting of two histone-fold-containing core subunits, and this family is one of these. As a family it is likely to carry binding regions for interactions with a number of the other components of the complex.


Pssm-ID: 463692  Cd Length: 135  Bit Score: 69.81  E-value: 1.02e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387639     7 ELEIAKKNLTDAIG-ENVKHYWANLKLWFKQKISKEEFDLEARRLLAQDNVHVHNDFLLAILTRCQIIVStsegpgslqw 85
Cdd:pfam12767   3 DLEELKTQLKKKLGpERWEKYFEALSRFLSGKLSKAELDKLCDPILGRENLHLHNQLILSILANAQEIRS---------- 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45387639    86 sggsaskpgkpsrgkkkfpsvrqkfdhRFQPqnPLAgvpvfspreaeeeelklsAQTLLLPSRGQLEARMMVSAFESDLD 165
Cdd:pfam12767  73 ---------------------------PYAA--PLA------------------YESGELPDTDSLRKRMEPIAYEHGLV 105

                         170       180
                  ....*....|....*....|....*....
gi 45387639   166 S-VAEDAVSCMLCALQVHLKDILTALVSR 193
Cdd:pfam12767 106 GgVSADCANLLNNALDVYLKNLLESCIDL 134
HFD_HFI1-like cd22925
histone-fold domain found in transcriptional coactivator HFI1, transcriptional adapter 1 ...
 150-209 2.58e-09

histone-fold domain found in transcriptional coactivator HFI1, transcriptional adapter 1 (TADA1), and similar proteins; This subfamily includes HFI1 and TADA1. HFI1, also called ADA1, is a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA (Spt-Ada-Gcn5-acetyltransferase) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TATA binding protein (TBP) interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA (SAGA altered, SPT8 absent), an altered form of SAGA, may be involved in positive transcriptional regulation. Besides lacking SPT8, SALSA contains an SPT7 subunit that is truncated. SLIK (SAGA-like) is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. HFI1/ADA1 and SPT20/ADA5 may recruit TATA binding protein (TBP) and possibly other basal factors to bind to the TATA box. TADA1, also called SPT3-associated factor 42, or STAF42, or transcriptional adapter 1-like protein (TADA1L), may be involved in transcriptional regulation. It functions as a component of the STAGA transcription coactivator-HAT complex, which is composed of at least SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP, and TAF9.


Pssm-ID: 467050  Cd Length: 53  Bit Score: 52.43  E-value: 2.58e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 45387639 150 QLEARMMVSAFESDLDS-VAEDAVSCMLCALQVHLKDILTALvsrrkayrLRDGHFLYAFG 209
Cdd:cd22925   1 TLRTRMTGISYEHGLIGpVDDDVVDIMAIALENHLKGILEAA--------LTIEDFADALE 53
HFD_HFI1 cd22933
histone-fold domain found in transcriptional coactivator HFI1 and similar proteins; HFI1, also ...
 138-206 6.03e-06

histone-fold domain found in transcriptional coactivator HFI1 and similar proteins; HFI1, also called ADA1, is a component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and SLIK. SAGA (Spt-Ada-Gcn5-acetyltransferase) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TATA binding protein (TBP) interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SALSA (SAGA altered, SPT8 absent), an altered form of SAGA, may be involved in positive transcriptional regulation. Besides lacking SPT8, SALSA contains an SPT7 subunit that is truncated. SLIK (SAGA-like) is proposed to have partly overlapping functions with SAGA. It preferentially acetylates methylated histone H3, at least after activation at the GAL1-10 locus. HFI1/ADA1 and SPT20/ADA5 may recruit TATA binding protein (TBP) and possibly other basal factors to bind to the TATA box.


Pssm-ID: 467057  Cd Length: 87  Bit Score: 43.75  E-value: 6.03e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 45387639 138 LSAQTLLLPSRGQLEARMMVSAFESDLDS-VAEDAVSCMLCALQVHLKDILTALVSRRKAYR-----LRDGHFLY 206
Cdd:cd22933   1 LCSESKELPDADSLRERMTGIALENGLLGgVAEECVELLLLALEQHLKNILSSCIDKVRARRtstltLEDLLLAL 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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