misexpression suppressor of KSR 2, isoform F [Drosophila melanogaster]
Protein Classification
alpha/beta hydrolase family protein( domain architecture ID 229394)
alpha/beta hydrolase family protein may catalyze the hydrolysis of substrates with different chemical composition or physicochemical properties using a nucleophile-His-acid catalytic triad
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| Abhydrolase super family | cl21494 | alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, ... |
133-419 | 1.93e-123 | |||||
alpha/beta hydrolases; A functionally diverse superfamily containing proteases, lipases, peroxidases, esterases, epoxide hydrolases and dehalogenases. The catalytic apparatus typically involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine, and often the mechanism involves a nucleophilic attack on a carbonyl carbon atom. The actual alignment was detected with superfamily member pfam03096: Pssm-ID: 473884 [Multi-domain] Cd Length: 285 Bit Score: 360.13 E-value: 1.93e-123
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| Name | Accession | Description | Interval | E-value | |||||
| Ndr | pfam03096 | Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ... |
133-419 | 1.93e-123 | |||||
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.). Pssm-ID: 397285 [Multi-domain] Cd Length: 285 Bit Score: 360.13 E-value: 1.93e-123
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| MenH | COG0596 | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ... |
129-258 | 1.01e-09 | |||||
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis Pssm-ID: 440361 [Multi-domain] Cd Length: 221 Bit Score: 58.47 E-value: 1.01e-09
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| Name | Accession | Description | Interval | E-value | |||||
| Ndr | pfam03096 | Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, ... |
133-419 | 1.93e-123 | |||||
Ndr family; This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases pfam00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.). Pssm-ID: 397285 [Multi-domain] Cd Length: 285 Bit Score: 360.13 E-value: 1.93e-123
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| MenH | COG0596 | 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ... |
129-258 | 1.01e-09 | |||||
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis Pssm-ID: 440361 [Multi-domain] Cd Length: 221 Bit Score: 58.47 E-value: 1.01e-09
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| Abhydrolase_1 | pfam00561 | alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes. |
173-316 | 4.85e-04 | |||||
alpha/beta hydrolase fold; This catalytic domain is found in a very wide range of enzymes. Pssm-ID: 395444 [Multi-domain] Cd Length: 245 Bit Score: 41.72 E-value: 4.85e-04
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| Blast search parameters | ||||
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