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Conserved domains on  [gi|45827723|ref|NP_996797|]
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EEF1A lysine methyltransferase 3 isoform b [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 106779)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 37-111 4.31e-14

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam10294:

Pssm-ID: 473071  Cd Length: 172  Bit Score: 65.43  E-value: 4.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827723    37 GHVLTITQNFGSrlGVAARVWDAALSLCNYFE------SQNVDFRGKKVIELGAGTGIVGILAALQGAYGLVRETE-DDV 109
Cdd:pfam10294   4 NPGLRIEEDTGN--GIGGHVWDAAVVLSKYLEmkifkeLGANNLSGLNVLELGSGTGLVGIAVALLLPGASVTITDlEEA 81


                  ..
gi 45827723   110 IE 111
Cdd:pfam10294  82 LE 83
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 37-111 4.31e-14

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 65.43  E-value: 4.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827723    37 GHVLTITQNFGSrlGVAARVWDAALSLCNYFE------SQNVDFRGKKVIELGAGTGIVGILAALQGAYGLVRETE-DDV 109
Cdd:pfam10294   4 NPGLRIEEDTGN--GIGGHVWDAAVVLSKYLEmkifkeLGANNLSGLNVLELGSGTGLVGIAVALLLPGASVTITDlEEA 81


                  ..
gi 45827723   110 IE 111
Cdd:pfam10294  82 LE 83
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
51-98 3.02e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 44.89  E-value: 3.02e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 45827723  51 GVAAR-VWDAALslcnyfesqNVDFRGKKVIELGAGTGIVGILAALQGA 98
Cdd:COG2263  29 ELAAElLHLAYL---------RGDIEGKTVLDLGCGTGMLAIGAALLGA 68
PRK14968 PRK14968
putative methyltransferase; Provisional
 76-99 5.63e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 38.34  E-value: 5.63e-04
                         10        20
                 ....*....|....*....|....
gi 45827723   76 GKKVIELGAGTGIVGILAALQGAY 99
Cdd:PRK14968  24 GDRVLEVGTGSGIVAIVAAKNGKK 47
 
Name Accession Description Interval E-value
Methyltransf_16 pfam10294
Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members ...
 37-111 4.31e-14

Lysine methyltransferase; Methyltrans_16 is a lysine methyltransferase. characterized members of this family are protein methyltransferases targetting Lys residues in specific proteins, including calmodulin, VCP, Kin17 and Hsp70 proteins.


Pssm-ID: 313513  Cd Length: 172  Bit Score: 65.43  E-value: 4.31e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 45827723    37 GHVLTITQNFGSrlGVAARVWDAALSLCNYFE------SQNVDFRGKKVIELGAGTGIVGILAALQGAYGLVRETE-DDV 109
Cdd:pfam10294   4 NPGLRIEEDTGN--GIGGHVWDAAVVLSKYLEmkifkeLGANNLSGLNVLELGSGTGLVGIAVALLLPGASVTITDlEEA 81


                  ..
gi 45827723   110 IE 111
Cdd:pfam10294  82 LE 83
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
51-98 3.02e-06

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 44.89  E-value: 3.02e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 45827723  51 GVAAR-VWDAALslcnyfesqNVDFRGKKVIELGAGTGIVGILAALQGA 98
Cdd:COG2263  29 ELAAElLHLAYL---------RGDIEGKTVLDLGCGTGMLAIGAALLGA 68
PRK14968 PRK14968
putative methyltransferase; Provisional
 76-99 5.63e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 38.34  E-value: 5.63e-04
                         10        20
                 ....*....|....*....|....
gi 45827723   76 GKKVIELGAGTGIVGILAALQGAY 99
Cdd:PRK14968  24 GDRVLEVGTGSGIVAIVAAKNGKK 47
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
70-98 9.25e-04

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 37.82  E-value: 9.25e-04
                         10        20
                 ....*....|....*....|....*....
gi 45827723   70 QNVDFRGKKVIELGAGTGIVGILAALQGA 98
Cdd:PRK00517 114 EKLVLPGKTVLDVGCGSGILAIAAAKLGA 142
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
72-98 9.65e-04

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 37.85  E-value: 9.65e-04
                        10        20
                ....*....|....*....|....*..
gi 45827723  72 VDFRGKKVIELGAGTGIVGILAALQGA 98
Cdd:COG2264 145 LLKPGKTVLDVGCGSGILAIAAAKLGA 171
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
76-98 2.44e-03

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 36.55  E-value: 2.44e-03
                        10        20
                ....*....|....*....|...
gi 45827723  76 GKKVIELGAGTGIVGILAALQGA 98
Cdd:COG4076  36 GDVVLDIGTGSGLLSMLAARAGA 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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